Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

Abstract: Topical formulation containing pregabalin for long-term analgesic activity. The composition is prepared using high shear mixers or homogenizers such as HPH or ultrasonic devices, which changes the structure of the composition. The analgesic effect of the compounds of the present invention is significantly increased compared to reference formulations homogenized with equipment of the same quantitative composition but less shearing forces.

Abstract: A linear drive comprising an electric motor driving a worm, a worm gear which meshes with the worm and which is connected non-rotatably to a spindle extending along a linear drive longitudinal axis or axis of rotation and which has a rear and a front end. The worm gear has a bearing seat for a rear bearing, with which the worm gear is mounted in a surrounding transmission housing. To simplify the manufacture of such a linear drive the invention proposes that the rear bearing is in the form of a fixed bearing, the spindle comprises a weldable material, a securing disk is arranged on the rear end of the spindle and the securing disk is connected to the spindle in bonded-material relationship.

Abstract: A linear drive comprising a transmission housing and an electric motor which is connected thereto and which drives a mounted shaft which in turn drives a worm which meshes with a worm gear which is non-rotatably connected to a spindle on which runs a spindle nut, arranged displaceably in a guide tube. Provided between the guide tube and the spindle nut to ensure correct rotary angle orientation of the spindle nut, in relation to the guide tube are inner barsa and complementary guide grooves. To simplify machine-assisted mounting of the spindle nut, in the guide tube there are provided positional orientation means which implement correct rotary angle orientation of the spindle nut, upon insertion thereof into the guide tube in the push-in direction.

Abstract: A bipolar battery includes a plurality of cell members, each including a positive electrode having a positive active material layer, a negative electrode having a negative active material layer, and an electrolyte layer interposed between the positive electrode and the negative electrode. The bipolar battery also includes a plurality of frame units respectively forming a plurality of cells respectively incorporating the plurality of cell members. Each of the plurality of frame units is a frame unit made of a light transmissive resin material. Two of the frame units made of the light transmissive resin material adjacent in a stacking direction of the cell members are welded and joined at a welded portion via a joining member made of a light absorbing resin material. This configuration can provide a bipolar battery capable of reliably preventing electrolytic solution leakage out of a cell by means of a simple seal structure.

Abstract: A bipolar battery includes a plurality of cell members and a plurality of frame units respectively forming a plurality of cells respectively incorporating the plurality of cell members. The plurality of frame units includes frame units made of a light transmissive resin material and frame units made of a light absorbing resin material that are alternately arranged in a stacking direction of the cell members. The frame units made of a light transmissive resin material and the frame units made of a light absorbing resin material adjacent in the stacking direction of the cell members are joined at welded portions. This configuration can provide a bipolar battery capable of reliably preventing electrolytic solution leakage out of a cell by means of a simple seal structure.

Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X = I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.

Abstract: A tool basic module for use with at least one attachment device includes a drive unit, a main output shaft having a shaft receptacle for at least partially receiving a main input shaft of the attachment device, and a coupling device, which has a mechanical interface for mechanically connecting the attachment device to the main output shaft with respect to driving and an electrical interface for transferring electric power and/or an electric current. The mechanical interface is at least in particular substantially cylindrical and has a plurality of interlocking connection elements, which in particular are uniformly arranged on an outer periphery of the mechanical interface and are provided for torque support of the attachment device.

Abstract: The present invention relates to the field of human therapy. In particular, the present invention relates to novel synthetic peptide-based chloride ion transporter and to compositions thereof, as well as methods of treating, reducing, inhibiting or controlling CFTR-mediated conditions in a subject, such as cystic fibrosis.

Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.

Abstract: A wiper device (10a-10f) for wiping a sensor system (30a-30f), in particular a lidar system, with at least one wiper unit (12a-12f), which comprises at least one wiper lip (16a-16f) for wiping a surface (38a-38f) of the sensor system (30a-30f) and with at least one pressing unit (14a-14f). It is proposed that the pressing unit (14a-14f) comprises at least one spring element (24a; 52b; 54c, 56c; 58d; 60e; 62f, 64f) for pressing the wiper unit (12a-12f) against the surface (38a-38f).

Abstract: A wiper device having a wiper arm (20a; 20b; 20c), having at least one wiper blade (18a, 18a?, 18a?) which is coupled to the wiper arm (20a; 20b; 20c), which includes at least one wiper lip (22a, 22a?, 22a?) for wiping a surface (16a; 16b; 16c) of a protective element (14a; 14b; 14c) of a sensor device (12a), in particular of a Lidar device, and having a wiper arm guide unit (24a) which is provided for moving the wiper arm (20a; 20b; 20c) in an at least substantially translatory manner along a guide path (50a). It is proposed that the wiper device has a rotary joint (26a) by means of which the wiper blade (18a, 18a?, 18a?) is pivotably mounted on the wiper arm (20a; 20b; 20c).

Abstract: The invention relates to a lidar device (10a-10l) having a cleaning unit (12a-12l) which has at least one wiper unit (14a-14l) having at least one wiper blade (16a-16l) for mechanically cleaning a cover element (18a-18l) of a lidar unit (20a-20l), and having at least one pressing element (22a-22l) which in a mounted state provides a pressing force for the wiper blade (16a-16l).

Abstract: A linear drive comprising a transmission housing and an electric motor which is connected thereto and which drives a mounted shaft which in turn drives a worm which meshes with a worm gear which is non-rotatably connected to a spindle on which runs a spindle nut, arranged displaceably in a guide tube. Provided between the guide tube and the spindle nut to ensure correct rotary angle orientation of the spindle nut, in relation to the guide tube are inner barsa and complementary guide grooves. To simplify machine-assisted mounting of the spindle nut, in the guide tube there are provided positional orientation means which implement correct rotary angle orientation of the spindle nut, upon insertion thereof into the guide tube in the push-in direction.

Abstract: A drive base module of a modularly constructed multifunctional handheld machine is configured to connect to at least one attachment device. The drive base module includes at least one connection device including at least one drive-technological interface and/or a data-technological interface configured to connect to the at least one attachment device. The drive base module further includes at least one drive unit configured to drive the at least one attachment device in a state in which the at least one attachment device is connected to the at least one connection device. The drive base module further includes at least one rechargeable battery unit; and at least one information output unit configured to output information to an operator acoustically and/or haptically.

Abstract: A linear drive comprising an electric motor driving a worm, a worm gear which meshes with the worm and which is connected non-rotatably to a spindle extending along a linear drive longitudinal axis or axis of rotation and which has a rear and a front end. The worm gear has a bearing seat for a rear bearing, with which the worm gear is mounted in a surrounding transmission housing. To simplify the manufacture of such a linear drive the invention proposes that the rear bearing is in the form of a fixed bearing, the spindle comprises a weldable material, a securing disk is arranged on the rear end of the spindle and the securing disk is connected to the spindle in bonded-material relationship.

Abstract: The invention relates to a robust and reproducible process for the preparation of polymorph form B of treprostinil diethanolamine salt, comprising the following steps: a. treprostinil is dissolved in methanol, b. to the solution of step a) diethanolamine or its methanol solution is added, c. the reaction mixture of step b) is agitated till dissolution, d. when salt formation is completed in step c), first portion of an aprotic solvent is added to the solution, e. the solution of step d) is filtered to remove insoluble impurities, f. the filtrate of step e) is seeded with polymorph form B of treprostinil diethanolamine salt, g. to the crystal suspension obtained in step f) a second portion of the aprotic solvent is added, h. the suspension of step g) is agitated until crystallisation is completed, i. the crystals are separated, washed and dried.

Abstract: The field of extracellular vesicles (EVs) currently attracts substantial attention in biomedicine due to the proposed role of EVs in various biological processes and their potential of serving as biomarkers for diseases. However, the availability of approaches for reliable and reproducible standardised quantification of EVs is limited. Therefore, current interest in EV research urges reliable tools of standardization and accurate enumeration of EVs, preferably on the basis of lipid quantification. By definition, EVs are surrounded by phospholipid bilayers, therefore, lipids (such as phospholipids and cholesterol) are essential components of all EVs. The method of the invention avoids the overestimation of EV concentration based on the protein measurement, as it focuses on the defining component of EVs, the lipid bilayer. Our method can be used virtually in any standard laboratories where a fume hood, a thermoblock, and a spectrophotometer are available.

Abstract: A tool basic module for use with at least one attachment device includes a drive unit, a main output shaft having a shaft receptacle for at least partially receiving a main input shaft of the attachment device, and a coupling device, which has a mechanical interface for mechanically connecting the attachment device to the main output shaft with respect to driving and an electrical interface for transferring electric power and/or an electric current. The mechanical interface is at least in particular substantially cylindrical and has a plurality of interlocking connection elements, which in particular are uniformly arranged on an outer periphery of the mechanical interface and are provided for torque support of the attachment device.