Abstract: A workflow manager can be configured to present a graphical interface to an entity and display a current status of a workflow via the graphical interface. Via the graphical interface, the entity can provide one or more indications that indicate an entry condition for the workflow, one or more message communications, and one or more filter conditions. The entity can activate the workflow and cause the workflow manager to identify a user population that satisfies the entry condition and cause the user population to be presented with the one or more message communications and the one or more filter conditions of the workflow. Different user segments of the user population may be assigned to different user paths, where each user segment receives different communications based on their corresponding user paths.

Abstract: A muzzle device for a firearm may include an additively manufactured body having a first end, a second end opposite the first end, and a central bore extending from the first end to the second end. The body may include a lattice of triply periodic minimal surfaces that define an interconnected network of channels extending through the body such that gases produced by the firearm may flow in a random pattern from the central bore through the interconnected network of channels to cool the gases.

Abstract: A muzzle device for a firearm may include an additively manufactured body having a first end, a second end opposite the first end, and a central bore extending from the first end to the second end. The body may include a lattice of triply periodic minimal surfaces that define an interconnected network of channels extending through the body such that gases produced by the firearm may flow in a random pattern from the central bore through the interconnected network of channels to cool the gases.

Abstract: A muzzle device for a firearm may include an additively manufactured body having a first end, a second end opposite the first end, and a central bore extending from the first end to the second end. The body may include a lattice of triply periodic minimal surfaces that define an interconnected network of channels extending through the body such that gases produced by the firearm may flow in a random pattern from the central bore through the interconnected network of channels to cool the gases.

Abstract: A muzzle device for a firearm may include an additively manufactured body having a first end, a second end opposite the first end, and a central bore extending from the first end to the second end. The body may include a lattice of triply periodic minimal surfaces that define an interconnected network of channels extending through the body such that gases produced by the firearm may flow in a random pattern from the central bore through the interconnected network of channels to cool the gases.

Abstract: A workflow manager can be configured to present a graphical interface to an entity and display a current status of a user population within an active workflow. The workflow manager can identify and monitor individual user actions associated with user paths of the active workflow. The workflow manager can generate user path and workflow analytics that identify the progress of individual users and summarize the overall progress of the user population within the active workflow. The workflow analytics can be generated from event notifications that are emitted by the communications and filters of the active workflow. The graphical interface can be actively updated, in response to the emission of the event notifications, to present the workflow analytics and user population progress to the entity.

Abstract: A workflow manager can be configured to present a graphical interface to an entity and display a current status of a workflow via the graphical interface. Via the graphical interface, the entity can provide one or more indications that indicate an entry condition for the workflow, one or more message communications, and one or more filter conditions. The entity can activate the workflow and cause the workflow manager to identify a user population that satisfies the entry condition and cause the user population to be presented with the one or more message communications and the one or more filter conditions of the workflow. Different user segments of the user population may be assigned to different user paths, where each user segment receives different communications based on their corresponding user paths.

Abstract: A workflow manager can be configured to present a graphical interface to an entity that displays a recommended activity for a workflow via the graphical interface. The entity can approve the recommended activity via the graphical interface and cause an updated workflow to be presented via the graphical interface. The entity can cause the workflow manager to present a recommended activity by submitting a high value action. The workflow manager can identify users from prior workflows that completed the high value action and configure the recommended addition based on those users. The entity can cause the workflow manager to identify users, generate the recommended activity, and update the activity over the workflow lifecycle.

Abstract: A workflow manager can be configured to present a graphical interface to an entity and display a current status of a user population within an active workflow. The workflow manager can identify and monitor individual user actions associated with user paths of the active workflow. The workflow manager can generate user path and workflow analytics that identify the progress of individual users and summarize the overall progress of the user population within the active workflow. The workflow analytics can be generated from event notifications that are emitted by the communications and filters of the active workflow. The graphical interface can be actively updated, in response to the emission of the event notifications, to present the workflow analytics and user population progress to the entity.

Abstract: Method and apparatus for transmitting selected pictorial information present in a host computing device to be displayed on an e-ink type display of a portable device that shows a displayed previous image, wherein the portable device obtains energy supply from the host computing device required for the refreshment of the displayed image, wherein the portable device calculates the energy required for the next refreshment and indicates when in the device sufficient energy is stored, for the calculation of the required energy the timing profile of the portable device is divided into segments, and only the segment of the profile is used which corresponds to the actual parameters required at the time of refreshment, whereby less energy is needed for the refreshment.

Abstract: Method and apparatus for transmitting selected pictorial information present in a host computing device to be displayed on an e-ink type display of a portable device that shows a displayed previous image, wherein the portable device obtains energy supply from the host computing device required for the refreshment of the displayed image, wherein the portable device calculates the energy required for the next refreshment and indicates when in the device sufficient energy is stored, for the calculation of the required energy the timing profile of the portable device is divided into segments, and only the segment of the profile is used which corresponds to the actual parameters required at the time of refreshment, whereby less energy is needed for the refreshment.

Abstract: In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof.

Abstract: In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof.

Abstract: The present invention relates to the preparation of hyperpolarized 89Y. Hyperpolarized 89Y may be used as nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) agents for sensitive detection and imaging.

Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

Abstract: The present invention relates to the preparation of hyperpolarized 89Y. Hyperpolarized 89Y may be used as nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) agents for sensitive detection and imaging.

Abstract: The present invention is directed, in general, to a contrast agent comprising a tetraazacyclododecane ligand and comprising a macrocyclic ring and a paramagnetic metal ion coordinated to the tetraazacyclododecane ligand. Pendent arms R, R?, R? and R?? attached to a ring nitrogen. The pendent arms have the general formula: ?C?HR1R2 and for three or more of the pendant arms a chirality of the carbon atoms C? are identical for each of three or more of the pendant arms. The R1 group is larger than hydrogen and R2 is selected from the group consisting of: an alcohol, amides, a carboxylate, phosphinates and a phosphonate. One or more substituents R6 is a group larger than a methyl group and is located on one or more ring carbons.

Abstract: The present invention is directed, in general, to a method for making high yields of functionalized cyclic or acyclic tertiary amine-containing compounds, termed active esters, the functionalized compounds themselves, and diagnostic or therapeutic systems incorporating such compounds. Ester groups are attached to all but one of its Nitrogen atoms of the tertiary amine-containing compound. Therefore, an active agent, in the presence of coupling agent, attaches to the remaining amine via a carboxylate group attached to the amine, to produce high yields of the active ester. The active ester is then combined with a biomolecule, to produce high yields of a bioconjugated product. A metal ion may be chelated to the bioconjugated product to produce a chelating agent for use in either diagnostic or therapeutic applications.