Patents by Inventor Zoltan Kupihar

Zoltan Kupihar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiocarbon-protecting groups for RNA synthesis
    Patent number: 9067961
    Abstract: Aspects of the invention include 2? protected nucleoside monomers that are protected at the 2? site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: June 30, 2015
    Assignees: Agilent Technologies, Inc., The Regents of the University of Colorado Denver
    Inventors: Douglas J. Dellinger, Agnieszka B. Sierzchala, John Turner, Joel Myerson, Zoltan Kupihar, Fernando Ferreira, Marvin H. Caruthers, Geraldine F. Dellinger
  • THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS
    Publication number: 20120238737
    Abstract: Aspects of the invention include 2? protected nucleoside monomers that are protected at the 2? site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
    Type: Application
    Filed: May 31, 2012
    Publication date: September 20, 2012
    Applicant: Agilent Technologies, Inc.
    Inventors: Douglas J. Dellinger, Agnieszka Sierzchala, John Turner, Joel Myerson, Zoltan Kupihar, Fernando Ferreira, Marvin H. Caruthers, Geraldine F. Dellinger
  • Thiocarbon-protecting groups for RNA synthesis
    Patent number: 8202983
    Abstract: Aspects of the invention include 2? protected nucleoside monomers that are protected at the 2? site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: June 19, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Douglas J. Dellinger, Agnieszka Sierzchala, John Turner, Joel Myerson, Zoltan Kupihar, Fernando Ferreira, Marvin H. Caruthers, Geraldine F. Dellinger
  • Thioether substituted aryl carbonate protecting groups
    Patent number: 8097711
    Abstract: Embodiments of the invention include nucleotide and nucleoside monomers protected at the 5?- or 3?-hydroxyls with thioether substituted aryl carbonate protecting groups. In certain cases, the carbonate protecting groups include an aryl moiety, e.g., a phenyl group, attached to the carbonate, where the aryl moiety further includes a thioether group, e.g., an alkyl or aryl thioether group, bound directly to the aryl ring. Aspects of the invention further include methods of synthesizing nucleic acids, e.g., oligonucleotides, using such protected nucleoside monomer monomers, as well as nucleic acids produced using methods of the invention and compositions thereof.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: January 17, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Zoltan Timar, Zoltan Kupihar, Douglas J. Dellinger, Marvin H. Caruthers
  • THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS
    Publication number: 20090209479
    Abstract: Aspects of the invention include 2? protected nucleoside monomers that are protected at the 2? site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
    Type: Application
    Filed: May 9, 2008
    Publication date: August 20, 2009
    Inventors: Douglas J. Dellinger, Agnieszka Sierzchala, John Turner, Joel Myerson, Zoltan Kupihar, Fernando Ferreira, Marvin H. Caruthers
  • Methods and compounds for polynucleotide synthesis
    Patent number: 7572907
    Abstract: Methods of forming polynucleotides are disclosed.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: August 11, 2009
    Assignees: Agilent Technologies, Inc., The Regents of the University of Colorado
    Inventors: Douglas J. Dellinger, Geraldine Dellinger, Marvin H. Caruthers, Zoltan Kupihar
  • Thioether substituted aryl carbonate protecting groups
    Publication number: 20080146787
    Abstract: Embodiments of the invention include thioether substituted aryl carbonate protecting groups, and nucleoside monomers protected with thioether substituted aryl carbonate protecting groups. Aspects of the invention further included methods of synthesizing nucleic acids, e.g., oligonucleotides, using such protected nucleoside monomer monomers, as well as nucleic acids produced using methods of the invention and compositions thereof.
    Type: Application
    Filed: August 31, 2007
    Publication date: June 19, 2008
    Inventors: Zoltan Timar, Zoltan Kupihar, Douglas J. Dellinger, Marvin H. Caruthers
  • Methods and compounds for polynucleotide synthesis
    Publication number: 20060247430
    Abstract: Methods of forming polynucleotides are disclosed.
    Type: Application
    Filed: April 29, 2005
    Publication date: November 2, 2006
    Inventors: Douglas Dellinger, Geraldine Dellinger, Marvin Caruthers, Zoltan Kupihar