Patents by Inventor Zoltan Maliga

Zoltan Maliga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic Dihydropyrimidines and Uses Thereof
    Publication number: 20100152206
    Abstract: The present invention provides compounds having formula (I): (I) and pharmaceutically acceptable derivatives thereof; as described generally and in subclasses herein, which compounds are useful as kinesin inhibitors (e.g., Eg5 inhibitors), and thus are useful, for example, for the treatment of proliferative disorders e.g., cancer. The invention additionally provides methods for preparing compounds of the invention, compositions comprising them, and methods for the use thereof in the treatment of various disorders where Eg5 is involved. In certain embodiments, the present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle.
    Type: Application
    Filed: January 6, 2006
    Publication date: June 17, 2010
    Inventors: Ralph Mazitschek, John A. Tallarico, Zoltan Maliga, Timothy J. Mitchison
  • Dihydropyrancarboxamides and uses thereof
    Publication number: 20080070916
    Abstract: The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1-R6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.
    Type: Application
    Filed: March 6, 2007
    Publication date: March 20, 2008
    Inventors: Stuart Schreiber, Robert Stavenger, Timothy Mitchison, Zoltan Maliga
  • Dihydropyrancarboxamides and uses thereof
    Patent number: 7186709
    Abstract: The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1–R6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: March 6, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Robert A. Stavenger, Timothy J. Mitchison, Zoltan Maliga
  • Kinesin inhibitors
    Patent number: 6890933
    Abstract: The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: May 10, 2005
    Assignee: President and Fellows of Harvard College
    Inventors: Yan Feng, Tarun M. Kapoor, Thomas Mayer, Zoltan Maliga, Timothy J. Mitchison, Justin Yarrow
  • Kinesin inhibitors
    Publication number: 20050004156
    Abstract: The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.
    Type: Application
    Filed: July 26, 2004
    Publication date: January 6, 2005
    Inventors: Yan Feng, Tarun Kapoor, Thomas Mayer, Zoltan Maliga, Timothy Mitchison, Justin Yarrow
  • Dihydropyrancarboxamides and uses thereof
    Publication number: 20040059138
    Abstract: The present invention provides novel dihydropyrancarboxamide compounds of formula (I): 1
    Type: Application
    Filed: August 27, 2003
    Publication date: March 25, 2004
    Inventors: Stuart L. Schreiber, Robert A. Stavenger, Timothy J. Mitchison, Zoltan Maliga