Patents by Inventor Zoltan Meszaros
Zoltan Meszaros has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190036345Abstract: A method for providing electrical balancing power for stabilizing an alternating-current grid that operates at a preset frequency of, for instance, 50 Hz. A combination unit provides the balancing power. The combination unit is composed of a battery forming an electrical storage device taking in electrical energy from the alternating-current grid or from a generating plant and supplying power to the grid over a first time period. A gas- and/or oil-CHP plant and a generator form an energy producer which, after a start-up phase, delivers energy into the grid over a second period of time. An open-loop and closed-loop controller controls the inflows and outflows of energy within the combination unit in dependence on a grid-control parameter reference value such that the electrical energy supplied to the alternating-current grid by the combination unit or taken from the alternating-current grid by the latter corresponds to the reference value of a balancing energy requisition.Type: ApplicationFiled: July 25, 2017Publication date: January 31, 2019Inventor: ZOLTAN MESZAROS
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Patent number: 4814336Abstract: A new method of treatment is disclosed for a vascular obstructive lesion resulting from restricted blood circulation, characterized by an erythrocyte pathology, in an effected animal subject. The new method involves the administration of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinolinium-theophylli ne-7-acetat e, in a dosage and at a rate sufficient to maintain a blood concentration of at least 0.5 to at most 3 .gamma./ml, calculated on the basis of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinoline.Type: GrantFiled: December 3, 1986Date of Patent: March 21, 1989Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Peter Szentmiklosi, Istvan Hermecz, Zoltan Meszaros, Laszo Tardos, Jeno Marton, Lelle Vasvari (nee Debreczy), Agnes Horvath, Katalin Marmarosi (nee Kellner)
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Patent number: 4806645Abstract: The invention relates to new 6-fluoro-7-chloro-1-methylamino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid/boric acid anhydrides of the general Formula I ##STR1## (wherein R and R.sup.1 stand for halogen; an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or an aromatic acyloxy group comprising 7-11 carbon atoms).The new compounds of the general Formula I are valuable intermediates useful in the preparation of the antibacterial agent 6-fluoro-1-methylamino-7-(4-methyl-piperazino)-4-oxo-1,4-dihydro-quinoline -3- carboxylic acid.The new compounds of the general Formula I may be prepared by reacting a compound of the Formula II ##STR2## or a compound of the general Formula III ##STR3## (wherein R.sup.2 stands for alkyl comprising 1-4 carbon atoms) with hydrogen fluoro borate of the Formula IVHBF.sub.4 /IV/or a borone trihalide of the general Formula VBX.sub.Type: GrantFiled: August 7, 1987Date of Patent: February 21, 1989Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Geza Kereszturi, Lelle Vasvari, Agnes Horvath, Maria Balogh, Gabor Kovacs, Zoltan Meszaros, deceased, Peter Ritli, Judit Sipos, Aniko Pajor
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Patent number: 4803274Abstract: The invention relates to a process for the preparation of compounds of the Formula I ##STR1## (wherein R and R.sup.1 stand for an aliphatic acyloxy group comprising 2-5 carbon atoms and optionally substituted by halogen or for an aromatic acyloxy group comprising 7-11 carbon atoms), which comprises reacting a compound of the general Formula II ##STR2## (wherein R.sup.2 stands for hydrogen or alkyl comprising 1-4 carbon atoms) with a boron derivative of the Formula III ##STR3## (wherein R.sup.3, R.sup.4 and R.sup.5 stand for an alkyl group comprising 1-4 carbon atoms and optionally substituted by halogen or for an aryl group comprising 6-10 carbon atoms).The new compounds of the general Formula I are useful pharmaceutical intermediates.Type: GrantFiled: August 7, 1987Date of Patent: February 7, 1989Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Geza Kereszturi, Lelle Vasvari, Agnes Horvath, Maria Balogh, Gabor Kovacs, Zoltan Meszaros, deceased, Peter Ritli, Judit Sipos, Aniko Pajor
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Patent number: 4666912Abstract: The invention relates to a process for the restoration and prevention of gastrointestinal injuries, which comprises treating a patient with an effective dose of racemic or optically active 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrimido[1,2-a]pyrimidine-3-c arboxamide.Type: GrantFiled: March 22, 1985Date of Patent: May 19, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termeker Gyara RTInventors: Zoltan Meszaros, Jozse Knoll, Istvan Hurmecz, Peter Szentmiklosi, Agnes Horvath, Lelle Vasvari nee Debreczy, Gabor Kovacs, Klara Gyires, Sandor Virag
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Patent number: 4495189Abstract: New compounds of the following formula are disclosed:1,6-dimethyl-3-carbamoyl-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)-pyrimidi ne;1,6-dimethyl-3-(N-tertiary-butyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyr ido(1,2-a)pyrimidine;1,6-dimethyl-3-(N-2-phenethyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido (1,2-a)pyrimidine;1,6-dimethyl-3-[N-(3,3-diphenyl-propyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro -4H-pyrido(1,2-a)pyrimidine;1,6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2- a)pyrimidine; and1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2- a)pyrimidine, as well as pharmaceutical compositions containing these compounds and a method of inhibiting thrombocyte aggregation in mammals employing a pharmaceutically effective amount of at least one of these compounds.Type: GrantFiled: April 2, 1982Date of Patent: January 22, 1985Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Zoltan Meszaros, Jozsef Knoll, Peter Szentmiklosi, Istvan Hermecz, Agnes Horvath, Sandor Virag, Lelle Vasvari, Agoston David
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Patent number: 4482557Abstract: New 3-substituted-2-oxo-tetrahydro-pyrrolo[1,2-a]pyrimidines of the formula (II) ##STR1## or a pharmaceutically acceptable acid addition or quaternary ammonium salts thereof are disclosed, whereinR is hydrogen or lower alkyl;R.sup.1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl, or carbohydrazido; andR.sup.2 is hydrogen or lower alkyl. The compounds exert a positive inotropic activity on the heart and have digitalis-like activity.Type: GrantFiled: September 9, 1982Date of Patent: November 13, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Gyorgy Szasz, Lelle Vasvari nee Debreczy, Agnes Horvath, Tibor Breining
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Patent number: 4472399Abstract: New Rutecarpine analogs are disclosed having Rutecarpine-like activity, especially diuretic activity. Also a novel process for the preparation of the Rutecarpine analogs is disclosed.Type: GrantFiled: October 2, 1981Date of Patent: September 18, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Sandor Virag, Lelle Vasvari, nee Debreczy, Gyorgy Szasz, Agnes Horvath, Tibor Breining, Tamas Szuts, Gyula Sebestyen
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Patent number: 4472398Abstract: Antiphlogistic and anticoagulant compounds of the formula: ##STR1## wherein m is 0, 1 or 2,n is 0, 1 or 2,R is C.sub.1 to C.sub.6 alkyl,R.sub.1 is hydrogen, or C.sub.1 to C.sub.6 alkyl,R.sub.2 is hydrogen, C.sub.1 to C.sub.6 alkyl, substituted or unsubstituted amino, substituted or unsubstituted hydroxy, carboxy or a group derived from a carboxylic acid orR.sub.1 and R.sub.2 together form a --(CH.dbd.CH).sub.2 --group andR.sub.5 is 0 or imino or substituted imino.Type: GrantFiled: February 23, 1979Date of Patent: September 18, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Zoltan Meszaros, Jozsef Knoll, Istvan Hermecz, Agnes Horvath, Sandor Virag, Lelle Vasvari, nee Debreczy, Agoston David
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Patent number: 4461769Abstract: Compounds of the formula I ##STR1## or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosedwhereinR is hydrogen or lower alkylR.sup.1 is hydrogen, lower alkyl, styryl, or a carboxylic acid; orR and R.sup.1 together form a group of the formula --(CH.dbd.CH).sub.2 -- and in this case the broken line represents a further C--C bond, while in all other cases there is a single bond between positions 6 and 7;R.sup.2 is hydrogen, lower alkyl or hydroxy;R.sup.3 is hydrogen, lower alkyl, aryl, lower alkanoyl, carboxyl or a carboxyl acid derivative or a group of the formula --(CH.sub.2)m--COOH or a derivative thereof formed in the carboxylic group;n=1-3;R.sup.4 is hydrogen, lower alkyl which can be substituted by hydroxy or carboxy; trifluoromethyl, substituted or unsubstituted aryl, phenyl-lower alkyl or substituted or an unsubstituted heterocyclic group;R.sup.Type: GrantFiled: September 19, 1979Date of Patent: July 24, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle Vasvari nee Debreczy, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szucs, Istvan Bitter, Gyula Sebestyen
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Patent number: 4460771Abstract: New optionally racemic or optically active pyrimido(1,2a) heterocyclic compounds of the formula ##STR1## wherein m is 0, 1 or 2,n is 0, 1 or 2,R is an alkyl group containing one to six carbon atoms,R.sup.1 is hydrogen, alkyl containing one to six carbon atoms,R.sup.2 is hydrogen, alkyl containing one to six carbon atoms, optionally substituted amino, optionally substituted hydroxy, carboxy or a group derived from a carboxylic acid orR.sup.1 and R.sup.2 together form a --(CH.dbd.CH).sub.2 -- group attached to the two adjacent carbon atoms of the ring A and the broken line represents a chemical bond,R.sup.3 is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocycle, optionally substituted cycloalkyl, optionally substituted acyl or optionally substituted hydroxy,R.sup.Type: GrantFiled: November 17, 1976Date of Patent: July 17, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Zoltan Meszaros, Jozsef Knoll, Peter Szentmiklosi, Istvan Hermes, Agnes Horvath, Sandor Virag, Lelle Vasvari nee Debreczy, Agoston David
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Patent number: 4404205Abstract: 3 Substituted hexahydro-pyrimido[1, 2 a]azepines and quaternary derivatives, useful as antianginals are prepared. Specifically tested are 3 carboxylates and carbo hydrazides. 3 Cyano Carbamonyl and alkyl compounds are also disclosed.Type: GrantFiled: May 9, 1980Date of Patent: September 13, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Gyorgy Szasz, Lelle Vasvari nee Debreczy, Agnes Horvath, Tibor Breining
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Patent number: 4395549Abstract: Intermediates useful in the preparation of Rutecarpine and Rutecarpine derivatives are disclosed as well as a process for the preparation of said intermediates having the following formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are the same or different and stand for hydrogen, halogen, nitro, carboxy, nitrile, alkoxy containing 1 to 4 carbon atoms, alkoxycarbonyl containing 1 to 4 carbon atoms in the alkoxy group, alkyl containing 1 to 4 carbon atoms, amino or hydroxy or R and R.sup.1 together stand for methylenedioxy, R.sup.2 stands for hydrogen, R.sup.3 represents hydrogen or alkyl containing 1 to 4 carbon atoms, R.sup.Type: GrantFiled: October 2, 1981Date of Patent: July 26, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Jozsef Kokosi, Agnes Horvath, Zoltan Meszaros, Gyorgy Szasz, Tibor Breining, Lelle Vasvari nee Debreczy
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Patent number: 4367229Abstract: Chemical compounds having an effect on the circulatory system have the formulas ##STR1## or a mixture thereof, or a pharmaceutically suitable acid-addition salt or quaternary salt thereof, whereinR is hydrogen or lower alkyl,R.sup.1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl or carbohydrazido,R.sup.2 is hydrogen or lower alkyl,and wherein the formula I R.sup.2 is hydrogen then R.sup.1 is other than nitrile, alkoxycarbonyl or propyl.Type: GrantFiled: May 9, 1980Date of Patent: January 4, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Gyorgy Szasz, Lelle Vasuarl nee Debreczy, Agnes Horvath, Tibor Breining
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Patent number: 4321377Abstract: Nitrogen bridgehead compounds (pyrido-[1,2-a]-pyrimidine derivatives) which are useful intermediates in the making of known compounds of this class and which themselves possess PG-antagonist, analgesic, antiartheriosclerotic, tranquilizing and like pharmaceutical activity.Type: GrantFiled: May 2, 1979Date of Patent: March 23, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Zoltan Meszaros, Istvan Bitter, Agnes Horvath, Lelle Vasvari nee Debreczy
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Patent number: 4291036Abstract: Compounds of the formula ##STR1## or pharmaceutically acceptable acid-addition or quaternart ammonium salts thereofwhereinR is hydroxy, carboxy, lower alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, carbamoyl, N-loweralkyl-carbamoyl, N,N-dilower-alkyl-carbamoyl, carboazido, carbohydrazido or cyano;R.sup.2 is C.sub.1 to C.sub.6 alkyl;R.sup.3 is C.sub.1 to C.sub.6 alkyl or benzyl; andR.sup.4 is a single electron pair, hydrogen or lower alkyl; and the dotted lines represent saturated or unsaturated bonds, are disclosed with analgesic properties.Type: GrantFiled: March 14, 1980Date of Patent: September 22, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Knoll, Zoltan Meszaros, Istvan Hermecz, Ferenc Fulop, Gabor Bernath, Sandor Virag, Gabor Nagy, Peter Szentmiklosi
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Patent number: 4260612Abstract: Antiallergic and antiasthmatic compounds of the formula ##STR1## of which 9-phenylamino-6-methyl-4-oxo-6,7-dihydro-4H-pyrido(1,2-a)pyrimidine-3-carb oxylic acid and optically active antipodes and salts thereof are examples.Type: GrantFiled: December 11, 1978Date of Patent: April 7, 1981Assignee: Chinoin Gyogyszer es Vecyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle Vasvari nee Debreczi, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szuts, Istvan Bitteer, Gyula Sebestyen
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Patent number: 4252807Abstract: An optically active or racemic fused pyrimidine derivative of the formula I ##STR1## has pharmaceutical activity in decreasing serum lipids, cholesterol deposits and, in general, against atherosclerosis.Type: GrantFiled: August 8, 1978Date of Patent: February 24, 1981Assignee: Chincin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Zoltan Meszaros, Sandor Virag, Lelle Vasvari, Agnes Horvath, Jozsef Knoll, Gyula Sebestyen, Agoston David
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Patent number: 4234586Abstract: Antiallergic and particularly antiasthmatic compounds of the formula: ##STR1## of which 9-phenylhydrazono-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimi dine-3-carboxylic acid is an especially significant example.Type: GrantFiled: December 11, 1978Date of Patent: November 18, 1980Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle V. Vasvari nee Debreczy, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szucs, Istvan Bitter, Gyula Sebestyen
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Patent number: 4220771Abstract: Pharmaceutical intermediates, morphine potentiators and other compounds have the formula ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy, nitro, amino, carboxy or a carboxylic acid derivate radical, R.sup.1 is hydrogen or a C.sub.1-4 alkyl, R.sup.2 is hydrogen or C.sub.1-4 alkyl, R.sup.3 is hydrogen, R.sup.4 is hydrogen or C.sub.1-4 alkyl, R.sup.5 is hydrogen R.sup.6 is hydrogen or R.sup.3 and R.sup.4 and/or R.sup.5 and R.sup.6 form a chemical bond, X is oxygen or imino, m is 1, 2, 3 or 4, n is 0, 1, 2 or 3, and if n is 1, then the dotted lines can stand for bonds, with the proviso that if m=1 and n=1 and if in the 2,3-, 6,7-, 8,9- and 1,10-positions double bonds are present, and R.sup.1 and R.sup.2 are hydrogen, then R is other than 9-hydroxy or 9-methyl; if m=2 and n=1 and R.sup.2 is hydrogen, then at least one of R and R.sup.1 is other than hydrogen; and if m=2 and n=2 and R.sup.2 is hydrogen and the molecule is a 2,3,4,6,7,8,9,10-octahydro derivative, then at least one of R and R.sup.Type: GrantFiled: August 18, 1978Date of Patent: September 2, 1980Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Istvan Hermecz, Ferenc Fulop, Zoltan Meszaros, Gabor Bernath, Jozsef Knoll