Patents by Inventor Zong Lin

Zong Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250188411
    Abstract: The present disclosure provides a method for selective removal of undifferentiated pluripotent stem cells including inducing stem cells differentiation, and then administering an effective amount of phthalide for the removal of undifferentiated pluripotent stem cells.
    Type: Application
    Filed: December 6, 2024
    Publication date: June 12, 2025
    Inventors: Chia-Yu Chang, Hsiao-Chien Ting, Shinn-Zong Lin, Horng-Jyh Harn, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen Chiou, Yu-Shuan Chen
  • Patent number: 12220550
    Abstract: Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: February 11, 2025
    Assignee: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Yu-Shuan Chen, Hsieh-Chih Tsai, Chang-Yi Lee, Haile Fentahun Darge, Shinn-Zong Lin, Tzyy-Wen Chiou, Chia-Yu Chang
  • Publication number: 20240228953
    Abstract: A method for promoting proliferation and enhancing expression of pluripotency factors of stem cells and a method for promoting proliferation of cells differentiated from the stem cells are provided in the present disclosure. The methods comprise culturing the stem cells in a medium comprising thrombospondin 1 (TSP1) and left-right determination factor 2 (LEFTY2). The present disclosure also provides a composition comprising a derivative of the stem cells produced by the methods of the present disclosure and a pharmaceutically or cosmetically acceptable carrier.
    Type: Application
    Filed: July 26, 2023
    Publication date: July 11, 2024
    Inventors: WU LI Wei, Shinn-Zong LIN, Tzyy-Wen CHIOU, Horng-Jyh HARN, Peng-Yeong WOON
  • Patent number: 11963969
    Abstract: Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: April 23, 2024
    Assignee: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Chia-Yu Chang, Shinn-Zong Lin, Hsiao-Chien Ting, Hui-I Yang, Horng-Jyh Harn, Hong-Lin Su, Ching-Ann Liu, Yu-Shuan Chen, Tzyy-Wen Chiou, Tsung-Jung Ho
  • Publication number: 20240082205
    Abstract: The present invention relates to the use of compounds of formula (I) and formula (II) and/or pharmaceutically acceptable salts of the aforementioned compounds in the treatment of meningioma and the reduction of the recurrence rate of meningioma. In formulas (I) and (II), R1 is C1-C20 alkyl, C3-C10 cycloalkyl, C6-C20 aryl, C1-C20 alkoxy, C6-C20 aryloxy, or halogen; p is 0 to 3; R2 is H, C1-C20 alkyl, or C6-C20 aryl; and R3 is H, C1-C20 alkyl, C3-C10 cycloalkyl, or C6-C20 aryl.
    Type: Application
    Filed: December 29, 2021
    Publication date: March 14, 2024
    Applicant: EVERFRONT BIOTECH INC.
    Inventors: Shinn-Zong LIN, Tsung-Lang CHIU, Horng-Jyh HARN, Tzyy-Wen CHIOU, Jui-Hao LEE
  • Publication number: 20240079450
    Abstract: A heterojunction bipolar transistor structure is provided, including a substrate and a multi-layer structure formed on the substrate. The multi-layer structure includes a current clamping layer, and the current clamping layer can be disposed in a collector layer, disposed in a sub-collector layer, or interposed between a collector layer and a sub-collector layer. An electron affinity of the current clamping layer is less than an electron affinity of an epitaxial layer formed on the current clamping layer.
    Type: Application
    Filed: August 31, 2023
    Publication date: March 7, 2024
    Inventors: Yu-Chung CHIN, Zong-Lin LI, Chao-Hsing HUANG
  • Patent number: 11920157
    Abstract: Applications of butylidenephthalide (BP), comprising the use of BP in providing a kit for promoting differentiation of stem cells into brown adipose cells, and the use of BP in preparing a medicament, wherein the medicament is used for inhibiting the accumulation of white adipose cells, promoting the conversion of white adipose cells into brown adipose cells, inhibiting weight gain and/or reducing the content of triglycerides, glucose, and total cholesterol in blood.
    Type: Grant
    Filed: September 15, 2022
    Date of Patent: March 5, 2024
    Assignee: NATIONAL DONG HWA UNIVERSITY
    Inventors: Tzyy-Wen Chiou, Shinn-Zong Lin, Horng-Jyh Harn, Hong-Lin Su, Shih-Ping Liu, Kang-Yun Lu, Jeanne Hsieh
  • Publication number: 20240016873
    Abstract: Provided is an herbal composition including an extract from an herbal raw material including at least one of Artemisia argyi, Ohwia caudata, Anisomeles indica (L.) O. Ktze, Ophiopogon japonicus, Houttuynia cordata, Platycodon grandiflorus, Glycyrrhiza uralensis, Perilla frutescens, and chrysanthemum. Also provided is a method for preparing the herbal composition and a method for preventing or treating a viral infection by administering an effective amount of the herbal composition to a subject in need thereof.
    Type: Application
    Filed: December 10, 2021
    Publication date: January 18, 2024
    Inventors: Cheng-Yen SHIH, Pi-Yu LIN, Shinn-Zong LIN, Chih-Yang HUANG, Tsung-Jung HO, Chien-Yi CHIANG, Yu-Jung LIN, Marthandam Asokan SHIBU, Wai-Ling LIM
  • Publication number: 20230407262
    Abstract: The present invention provides a medicine for treating a neurodegenerative disease, which employs LEFTY2 (Left-Right Determination Factor 2) generated by co-culturing mesenchymal stem cells of mammals with nerve cells having mutations in the APP (Amyloid precursor protein) gene, or a specific protein. The LEFTY2 has an effect of inhibiting Beta amyloid and a hyperphosphorylated neuronal microtubule-associated protein (Tau protein), without affecting the development of nerve cells and having the ability to promote the growth of the nerve cells; and the two types of proteins have a crucial impact on the neurodegenerative diseases.
    Type: Application
    Filed: November 14, 2022
    Publication date: December 21, 2023
    Inventors: Wei Wu Li, Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin, Ming-Hsi Chuang, Po-Cheng Lin, Chia-Hsin Lee, Mao-Hsuan Huang
  • Patent number: 11763935
    Abstract: A care system for predicting bed exit and suitable for a frame supporting a patient is provided. The care system includes a boundary-crossing detection system, a location sensing system, and a control circuit. The boundary-crossing detection system is coupled with the frame. The location sensing system is coupled with the frame, and is for obtaining relative position information between the patient and the frame. The control circuit is for data communicating with the boundary-crossing detection system and the location sensing system, and is for accessing care data defining multiple bed-exit behaviors. When one of following situations occurs, the control circuit transmits a warning signal: (1) the control circuit determines that, according to the relative position information and the care data, a current behavior of the patient corresponds to one of the multiple bed-exit behaviors; and (2) the boundary-crossing detection system senses that an object is passing through.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: September 19, 2023
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Chih-Lung Lin, Po-Ting Lee, Zong-Lin Yang
  • Publication number: 20230263813
    Abstract: Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.
    Type: Application
    Filed: September 16, 2022
    Publication date: August 24, 2023
    Inventors: Chia-Yu CHANG, Shinn-Zong LIN, Hsiao-Chien TING, Hui-I YANG, Horng-Jyh HARN, Hong-Lin SU, Ching-Ann LIU, Yu-Shuan CHEN, Tzyy-Wen CHIOU, Tsung-Jung HO
  • Publication number: 20230159889
    Abstract: Uses of n-butylidenephthalide (BP) in dopaminergic progenitor cell transplantation are provided, wherein the uses include using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation, and using a combination of BP and BP-treated dopaminergic progenitor cells in dopaminergic progenitor cell transplantation. The uses especially relate to using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation on Parkinson’s disease.
    Type: Application
    Filed: January 26, 2023
    Publication date: May 25, 2023
    Inventors: MING-HSI CHUANG, LIN-HSIANG CHUANG, PO-CHENG LIN, CHIA-HSIN LEE, YI-CHUN LIN, CHI-HSUAN CHUANG, SHINN-ZONG LIN, CHIA-YU CHANG, CHING-I SHEN
  • Publication number: 20230149678
    Abstract: Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 18, 2023
    Applicant: BUDDHIST TZU CHI MEDICAL FOUNDATION
    Inventors: Yu-Shuan Chen, Hsieh-Chih Tsai, Chang-Yi Lee, Haile Fentahun Darge, Shinn-Zong Lin, Tzyy-Wen Chiou, Chia-Yu Chang
  • Publication number: 20230092775
    Abstract: Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A prostatic implant deployment and delivery system may have a controlled release mechanism, a handle mechanism and an irrigation system. The controlled release mechanism includes a disengageable connection between a pusher member and the prostatic implant with a control member. The handle mechanism includes a plunger for advancing the pusher member and an actuator for withdrawing the control member. The irrigation system may define two fluid paths.
    Type: Application
    Filed: September 20, 2022
    Publication date: March 23, 2023
    Inventors: Chun-Chia Juan, Zong-Lin Li, De-Yu Chu, Yu-Chen Lin, Chiu-Ming Hsu, Yu-Shih Weng, Ying-Siao Chen
  • Publication number: 20230092846
    Abstract: A combination, comprising a first component and a second component; the first component is selected from a group composed of the following: the compound of formula (I), a pharmaceutically acceptable salt thereof, and a combination thereof, wherein A is a C1-C8 aliphatic hydrocarbon group optionally containing a carbonyl group as needed; X is H or OH; Y is O; and R1 is H or is not present, the condition being that when R1 is not present, Y and A bond to form a five-membered ring; and the second component is selected from a group composed of the following: a topoisomerase inhibitor, a microtubule assembly inhibitor, a platinum-based agent, an antimetabolite, and a combination thereof.
    Type: Application
    Filed: January 14, 2021
    Publication date: March 23, 2023
    Applicant: EVERFRONT BIOTECH INC.
    Inventors: Tzyy-Wen CHIOU, Horng-Jyh HARN, Shinn-Zong LIN, Jui-Hao Lee, Jen-Wei Liu, Szu-Yin Lin
  • Publication number: 20230059769
    Abstract: A facial skin disorder (FSD) identification system is provided and includes a sliding rail arranged around a human facial epidermis, a carrier arranged on the sliding rail, at least one image capturing device arranged on the carrier, and a control circuit unit arranged on the carrier for the carrier to move on the sliding rail and the image capturing device to capture images of the human facial epidermis.
    Type: Application
    Filed: January 27, 2022
    Publication date: February 23, 2023
    Applicants: BUDDHIST TZU CHI MEDICAL FOUNDATION, NATIONAL APPLIED RESEARCH LABORATORIES
    Inventors: Chung-Hsing Chang, Shinn-Zong Lin, Chun-Ming Chang, Nai-Yuan Chiang, Rou-Jhen Chen, Han-Chao Chang
  • Publication number: 20230023270
    Abstract: Applications of butylidenephthalide (BP), comprising the use of BP in providing a kit for promoting differentiation of stem cells into brown adipose cells, and the use of BP in preparing a medicament, wherein the medicament is used for inhibiting the accumulation of white adipose cells, promoting the conversion of white adipose cells into brown adipose cells, inhibiting weight gain and/or reducing the content of triglycerides, glucose, and total cholesterol in blood.
    Type: Application
    Filed: September 15, 2022
    Publication date: January 26, 2023
    Inventors: Tzyy-Wen Chiou, Shinn-Zong Lin, Horng-Jyh Harn, Hong-Lin Su, Shih-Ping Liu, Kang-Yun Lu, Jeanne Hsieh
  • Publication number: 20220331370
    Abstract: This invention relates to cell-based treatment of cardiovascular disease. The invention also provides treatments to improve neural tissue and to improve behavior and neurological function in cardiovascular disease patients as well as patients suffering from other forms of neurological stress or damage.
    Type: Application
    Filed: August 20, 2020
    Publication date: October 20, 2022
    Applicant: Stemcyte Inc.
    Inventors: Jonas Wang, Shinn Zong Lin, Horng-Jyh Harn, Po-Cheng Lin
  • Patent number: 11345888
    Abstract: This present invention provides a method for continuously maintaining growth of a motor neuron progenitor cell and a pharmaceutical composition. Wherein, the method for continuously maintaining growth of a motor neuron progenitor cell is to culture the motor neuron progenitor cell in an environment which is constructed by the olfactory ensheathing cells to make the motor neuron progenitor cell sustain the ability to self-replicate and to be induced for differentiating into mature neuron, and therefore to elaborate the effect to protect the motor neuron. The motor neuron progenitor cell produced from the method disclosed in this present invention can be an effective ingredient of the pharmaceutical composition for treating related diseases of damaged motor neuron.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: May 31, 2022
    Assignee: TAIWAN MITOCHONDRION APPLIED TECHNOLOGY
    Inventors: Hong-Lin Su, Hung-Chuan Pan, Hsiu-Chin Lee, Chun-Wei Chuang, Shinn-Zong Lin, Horng-Jyh Harn
  • Patent number: 11318170
    Abstract: The invention relates to the treatment of chronic stroke, traumatic brain injury, and neurodegenerative disorders using umbilical cord blood cells.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: May 3, 2022
    Assignee: StemCyte, Inc.
    Inventors: Shinn-Zong Lin, Woei-Cherng Shyu, Hung Li