Abstract: The present application relates to a three-dimensional carboxylic acid covalent organic framework, a preparation method thereof, and an application thereof. The three-dimension carboxylic acid covalent organic framework is formed by connecting a monomer to a compound via imine bonds formed by reacting formyl groups in the monomer with amino groups in the compound. The monomer is represented by structural formula I, II, or III, wherein R1 is selected from C, Si, substituted or unsubstituted biphenyl, or where * denotes a linking site; R2 to R31 are independently selected from H, C1-C6 linear alkyl, C1-C6 branched alkyl, or C1-C6 alkoxyl. The compound is represented by structural formula IV or V, wherein R34 to R41 are independently selected from H, Cl, Br, F, I, carboxyl, nitro, hydroxyl, C1-C6 linear alkyl, C1-C6 branched alkyl, or C1-C6 alkoxyl, and at least one of R34 to R41 is carboxyl.

Abstract: The present invention provides a novel pan-RAF kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a use or method of the compound of formula (I) in the treatment or prevention of a disorder related to the activity of RAF and/or RAS kinase.

Abstract: The present invention continuously generates a signal at an acceptable frequency without utilizing the PLL to modify the operation of the VCO. When the VCO is initialized properly to output a signal at a specific frequency, the VCO operates on its own to continuously output signals, and the VCO state is modified at regular intervals. Thus, when the interval is short enough and when the VCO is modified to the initial state every time, the VCO state will not deviate significantly from the initial state during these intervals. Thus, the VCO continuously generate signals with frequencies acceptably closed to the specific frequency. That is to say, the invention utilizes the injection lock to modify the operation of the VCO. To compare with the convention skills utilizing the PLL which has to feed back the signal generated by the VCO to the PLL for modifying the VCO state dynamically, the utilization of the injection lock simplifies the hardware and streamlines the process.

Abstract: A wrist device, system, or method for compressing a wrist that includes a shell, a compression mechanism, and an actuator. The shell is shaped to conform to the wrist, has a radius side and an ulna side opposite the radius side, and a thumb support. The compression mechanism is associated with the radius and ulna sides of the shell. The actuator is associated with the shell and is configured to provide compression in a radioulnar direction to opposing sides of the wrist via the compression mechanism.

Abstract: In order to more accurately and precisely diagnose conditions affecting joint spacing, a joint space quantification system is disclosed that identifies each bone in a three-dimensional medical image, generates a three-dimensional computer model that includes a three-dimensional representation of each bone, and identifies bone distances (e.g., shortest distances, centroid distances, etc.) between each three-dimensional representation. The joint space quantification system may then identify conditions affecting joint spacing (and quantify the severity of those conditions), for example by comparing the identified bone distances to previous bone distances of the patient and/or the bone distances of patients diagnosed with conditions affecting joint spacing.