Patents by Inventor Zong-Qiang Tian

Zong-Qiang Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOQUINONE ANSAMYCINS
    Publication number: 20090111869
    Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
    Type: Application
    Filed: June 18, 2008
    Publication date: April 30, 2009
    Applicant: Kosan Biosciences, Inc.
    Inventors: Daniel SANTI, David C. Myles, Zong-Qiang Tian, C. Richard Hutchinson, Robert Johnson, Yi-Qing Zhou, Li Feng
  • Benzoquinone ansamycins
    Patent number: 7405208
    Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: July 29, 2008
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel Santi, David C. Myles, Zong-Qiang Tian, C. Richard Hutchinson, Robert Johnson, Yi-Qing Zhou, Li Feng
  • Geldanamycin compounds and method of use
    Patent number: 7378407
    Abstract: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: May 27, 2008
    Assignee: Kosan Biosciences Incorporated
    Inventors: Daniel V. Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang
  • Geldanamycin compounds and method of use
    Publication number: 20070270396
    Abstract: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
    Type: Application
    Filed: July 6, 2007
    Publication date: November 22, 2007
    Applicant: Kosan Biosciences Incorporated
    Inventors: Daniel Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang
  • Geldanamycin compounds and method of use
    Patent number: 7259156
    Abstract: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: August 21, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Daniel V. Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang
  • 2-Desmethyl ansamycin compounds
    Patent number: 7241754
    Abstract: 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: July 10, 2007
    Assignee: Kosan Biosciences, Inc.
    Inventors: Zong-Qiang Tian, Robert McDaniel, David C. Myles, Kedar Gautam Patel, Misty Piagentini, Zhan Wang
  • Ambruticin VS compounds
    Publication number: 20070015823
    Abstract: Antifungal compounds represented by formula I where R1, R2, R3 and R4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum ambM, ambO, ambP, and ambS mutant strains; a recombinant Sorangium cellulosum strain that produces 24-norambruticin compounds; and a method for treating a fungal infection using a compound of this invention.
    Type: Application
    Filed: December 16, 2005
    Publication date: January 18, 2007
    Inventors: Zong-Qiang Tian, David Myles, Zhan Wang, Yuan Xu, Bryan Julien, Eduardo Rodriguez, Mark Shimazu, Greg Buchanan, Leonard Katz
  • Geldanamycin compounds and method of use
    Publication number: 20050267046
    Abstract: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
    Type: Application
    Filed: May 17, 2005
    Publication date: December 1, 2005
    Inventors: Daniel Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang
  • Benzoquinone ansamycins
    Publication number: 20050261263
    Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
    Type: Application
    Filed: February 11, 2005
    Publication date: November 24, 2005
    Inventors: Daniel Santi, David Myles, Zong-Qiang Tian, C. Hutchinson, Robert Johnson, Yi-Qing Zhou, Li Feng
  • 11-O-METHYLGELDANAMYCIN COMPOUNDS
    Publication number: 20050101656
    Abstract: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
    Type: Application
    Filed: April 16, 2004
    Publication date: May 12, 2005
    Applicant: Kosan Biosciences, Inc.
    Inventors: Zong-Qiang Tian, Yaoquan Liu, David Myles, Zhan Wang
  • 11-O-methylgeldanamycin compounds
    Patent number: 6887993
    Abstract: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: May 3, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Zong-Qiang Tian, Yaoquan Liu, David C. Myles, Zhan Wang
  • 11-O-methylgeldanamycin compounds
    Patent number: 6875863
    Abstract: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: April 5, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Zong-Qiang Tian, Yaoquan Liu, David C. Myles, Zhan Wang
  • Benzoquinone ansamycins
    Patent number: 6872715
    Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: March 29, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel Santi, David C. Myles, Zong-Qiang Tian, C. Richard Hutchinson, Robert Johnson, Yi-Qing Zhou, Li Feng
  • 11-O-methylgeldanamycin compounds
    Patent number: 6870049
    Abstract: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: March 22, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Zong-Qiang Tian, Yaoquan Liu, David C. Myles, Zhan Wang
  • 11-O-methylgeldanamycin compounds
    Patent number: 6855705
    Abstract: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: February 15, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Zong-Qiang Tian, Yaoquan Liu, David C. Myles, Zhan Wang
  • 2-Desmethyl ansamycin compounds
    Publication number: 20050026894
    Abstract: 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents.
    Type: Application
    Filed: June 14, 2004
    Publication date: February 3, 2005
    Inventors: Zong-Qiang Tian, Robert McDaniel, David Myles, Kedar Patel, Misty Piagentini, Zhan Wang
  • Motilide compounds
    Publication number: 20040147461
    Abstract: The present invention provides novel macrolide compounds of the formulas 1
    Type: Application
    Filed: November 12, 2003
    Publication date: July 29, 2004
    Inventors: Gary Ashley, Brian Metcalf, Zong-Qiang Tian, Daniel Santi
  • Compounds and compositions as protease inhibitors
    Patent number: 6593327
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: July 15, 2003
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Novel compounds and compositions as protease inhibitors
    Publication number: 20030119788
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: September 9, 2002
    Publication date: June 26, 2003
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Benzoquinone ansamycins
    Publication number: 20030114450
    Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
    Type: Application
    Filed: August 5, 2002
    Publication date: June 19, 2003
    Inventors: Daniel Santi, David C. Myles, Zong-Qiang Tian, C. Richard Hutchinson, Robert Johnson, Yi-Qing Zhou, Li Feng