Patents by Inventor Zong Sean Juo

Zong Sean Juo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant ROBO2 proteins, compositions, methods and uses thereof
    Patent number: 11970524
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: April 30, 2024
    Assignees: PFIZER INC., BOSTON MEDICAL CENTER CORPORATION
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • ANTIBODIES TARGETING FLT3 AND USE THEREOF
    Publication number: 20240132598
    Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting FLT3 on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.
    Type: Application
    Filed: October 13, 2020
    Publication date: April 25, 2024
    Inventors: Hemanta Baruah, Gregory P. Chang, Ann F. Cheung, Asya Grinberg, Zong Sean Juo, Thomas J. McQuade
  • PROTEINS BINDING NKG2D, CD16 AND FLT3
    Publication number: 20240117054
    Abstract: Multi-specific binding proteins that bind NKG2D receptor, CD 16, and FLT3 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of autoimmune disease or cancer.
    Type: Application
    Filed: October 14, 2020
    Publication date: April 11, 2024
    Inventors: Hemanta Baruah, Gregory P. Chang, Ann F. Cheung, Asya Grinberg, Zong Sean Juo, Thomas J. McQuade, Daniel Fallon, William Haney, Steven O'Neil, Ronnie Wei
  • ENGINEERED SIRPa VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20240083960
    Abstract: This disclosure relates to engineered SIRP? variants, and methods of use thereof.
    Type: Application
    Filed: October 31, 2023
    Publication date: March 14, 2024
    Inventors: Jiin-Tarng Wang, Han-Fang Teng, Pan-Hsien Kuo, Chi-Ling Tseng, Zong Sean Juo
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20230416405
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: March 13, 2023
    Publication date: December 28, 2023
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • ANTIBODIES TARGETING EGFR AND USE THEREOF
    Publication number: 20230279121
    Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting EGFR on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.
    Type: Application
    Filed: August 5, 2021
    Publication date: September 7, 2023
    Inventors: Asya Grinberg, Zong Sean Juo, Katia Liharska, Christopher Ryan Morgan
  • PROTEINS BINDING NKG2D, CD16 AND EGFR
    Publication number: 20230257467
    Abstract: Described herein are multispecific binding proteins that bind NKG2D receptor, CD 16, and EGFR, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
    Type: Application
    Filed: August 5, 2021
    Publication date: August 17, 2023
    Inventors: Ann F. Cheung, Stacey V. Drabic, Asya Grinberg, Zong Sean Juo, Katia Liharska, Christopher Ryan Morgan, Nicolai Wagtmann
  • PPHARMACEUTICAL FORMULATIONS AND THERAPEUTIC USES OF MULTI-SPECIFIC BINDING PROTEINS THAT BIND EGFR, NKG2D, AND CD16
    Publication number: 20230250176
    Abstract: Described herein are pharmaceutical formulations comprising multi-specific binding proteins that bind to NKG2D, CD16, and epidermal growth factor receptor (EGFR); and therapeutic uses of the multi-specific binding proteins and pharmaceutical formulations thereof for treating a disease, for example, cancer, in a patient in need thereof.
    Type: Application
    Filed: February 9, 2023
    Publication date: August 10, 2023
    Inventors: Ann F. Cheung, Jean-Marie Cuillerot, Mark DeRose, Stacey V. Drabic, Asya Grinberg, Zong Sean Juo, Aaron Levin, Katia Liharska, Lynn Markowitz, Christopher Ryan Morgan, Avni Shah, Michael Shifrin, Nicolai Wagtmann
  • ANTIBODIES TARGETING 5T4 AND USES THEREOF
    Publication number: 20230220106
    Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting 5T4 on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.
    Type: Application
    Filed: December 6, 2022
    Publication date: July 13, 2023
    Inventors: Pyae P. Hein, Zong Sean Juo, Xinbi Li, Christopher Ryan Morgan
  • PROTEINS BINDING NKG2D, CD16 AND 5T4
    Publication number: 20230203202
    Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and 5T4 are described, as well as pharmaceutical compositions, formulations, and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer.
    Type: Application
    Filed: December 6, 2022
    Publication date: June 29, 2023
    Inventors: Mitchell Bigelow, Mark DeRose, Jinyan Du, Robin Friedman, Pyae P. Hein, Stuart William Hicks, Zong Sean Juo, Xinbi Li, Christopher Ryan Morgan
  • Tissue factor pathway inhibitor antibodies and uses thereof
    Patent number: 11634504
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: April 25, 2023
    Assignee: Pfizer Inc.
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • Anti-ROBO2 antibodies, compositions, methods and uses thereof
    Patent number: 11365253
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: June 21, 2022
    Assignees: Pfizer Inc., Boston Medical Center Corporation
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Eric M. Bennett, Nathan Higginson-Scott, Huilan Gao, Zong Sean Juo, Stefano V. Gulla, Christine Huard, Sreekumar R. Kodangattil, Jian Li, Weining Lu, Xueping Fan, David J. Salant
  • PROTEINS BINDING NKG2D, CD16 AND CLEC12A
    Publication number: 20220119534
    Abstract: Described herein are multispecific binding proteins that bind NKG2D receptor, CD16, and CLEC12A, pharmaceutical compositions comprising the multispecific binding proteins, and therapeutic methods useful for the treatment of cancer.
    Type: Application
    Filed: May 5, 2021
    Publication date: April 21, 2022
    Inventors: Hemanta Baruah, Gregory P. Chang, Ann F. Cheung, Daniel Fallon, Asya Grinberg, Zong Sean Juo, Christopher Ryan Morgan
  • RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND USES THEREOF
    Publication number: 20210214414
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 15, 2021
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • Designer osteogenic proteins
    Patent number: 11008373
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: May 18, 2021
    Assignee: Wyeth, LLC.
    Inventors: Stephen Berasi, Robert Vincent Martinez, Michael John Cain, John Martin Wozney, Howard Seeherman, Zong Sean Juo, Valerie Perrine Calabro, Christopher Todd Brown
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20210101998
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: November 24, 2020
    Publication date: April 8, 2021
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • Recombinant ROBO2 proteins, compositions, methods and uses thereof
    Patent number: 10906955
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: February 2, 2021
    Assignees: Pfizer Inc., Boston Medical Center Corporation
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • Tissue factor pathway inhibitor antibodies and uses thereof
    Patent number: 10875929
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: December 29, 2020
    Assignee: Pfizer Inc.
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
    Publication number: 20200190214
    Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 18, 2020
    Inventors: Debra Pittman, James R. Apgar, Zong Sean Juo, Macy Jin, Mark Stahl, Gregory J. Carven, Matthew Holsti, Susan Benard, Sunita R. Hett, Reema Jasuja
  • ANTI-ROBO2 ANTIBODIES, COMPOSITIONS, METHODS AND USES THEREOF
    Publication number: 20200157212
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: May 21, 2020
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Eric M. Bennett, Nathan Higginson-Scott, Huilan Gao, Zong Sean Juo, Stefano V. Gulla, Christine Huard, Sreekumar R. Kodangattil, Jian Li, Weining Lu, Xueping Fan, David J. Salant