Abstract: Multi-specific binding proteins that bind NKG2D receptor, CD 16, and FLT3 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of autoimmune disease or cancer.

Abstract: Aspects of the invention include systems and methods configured to prevent masquerading service attacks. A non-limiting example computer-implemented method includes sending, from a first server in a cloud environment, a communication request comprising an application programming interface (API) key and a first server identifier to an identity and access management (IAM) server of the cloud environment. The API key can be uniquely assigned by the IAM server to a first component of the first server. The first server receives a credential that includes a token for the first component and sends the credential to a second server. The second server sends the credential, a second server identifier, and an identifier for a second component of the second server to the IAM server. The second server receives an acknowledgment from the IAM server and sends the acknowledgment to the first server.

Abstract: The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency.

Abstract: Systems and methods for observing a sample in a multi-beam apparatus are disclosed. A charged particle optical system may include a deflector configured to form a virtual image of a charged particle source and a transfer lens configured to form a real image of the charged particle source on an image plane. The image plane may be formed at least near a beam separator that is configured to separate primary charged particles generated by the source and secondary charged particles generated by interaction of the primary charged particles with a sample. The image plane may be formed at a deflection plane of the beam separator. The multi-beam apparatus may include a charged-particle dispersion compensator to compensate dispersion of the beam separator. The image plane may be formed closer to the transfer lens than the beam separator, between the transfer lens and the charged-particle dispersion compensator.

Abstract: Methods are provided for reducing blood glucose, which utilize an agent that increases the biological activity of a vitamin D receptor (VDR) (e.g., a VDR agonist), in combination with an antagonist of bromodomain-containing protein 9 (BRD9). IN some examples, such methods treat type II diabetes.

Abstract: Systems and methods for observing a sample in a multi-beam apparatus are disclosed. A charged particle optical system may include a deflector configured to form a virtual image of a charged particle source and a transfer lens configured to form a real image of the charged particle source on an image plane. The image plane may be formed at least near a beam separator that is configured to separate primary charged particles generated by the source and secondary charged particles generated by interaction of the primary charged particles with a sample. The image plane may be formed at a deflection plane of the beam separator. The multi-beam apparatus may include a charged-particle dispersion compensator to compensate dispersion of the beam separator. The image plane may be formed closer to the transfer lens than the beam separator, between the transfer lens and the charged-particle dispersion compensator.

Abstract: The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency. In particular embodiments the invention is predicated upon increased expression of an estrogen related receptor and changes in the oxidative and glycolytic pathways.

Abstract: Methods are provided for reducing blood glucose, which utilize an agent that increases the biological activity of a vitamin D receptor (VDR) (e.g., a VDR agonist), in combination with an antagonist of bromodomain-containing protein 9 (BRD9). IN some examples, such methods treat type II diabetes.

Abstract: Systems and methods for observing a sample in a multi-beam apparatus are disclosed. A charged particle optical system may include a deflector configured to form a virtual image of a charged particle source and a transfer lens configured to form a real image of the charged particle source on an image plane. The image plane may be formed at least near a beam separator that is configured to separate primary charged particles generated by the source and secondary charged particles generated by interaction of the primary charged particles with a sample. The image plane may be formed at a deflection plane of the beam separator. The multi-beam apparatus may include a charged-particle dispersion compensator to compensate dispersion of the beam separator. The image plane may be formed closer to the transfer lens than the beam separator, between the transfer lens and the charged-particle dispersion compensator.

Abstract: The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency. In particular embodiments the invention is predicated upon increased expression of an estrogen related receptor and changes in the oxidative and glycolytic pathways.

Abstract: The present invention discloses a phenanthrene derivative having the following structure: wherein Ar1 and Ar2 independently are phenyl, nathphyl, heterocyclic group, polycyclic aromatic or polycyclic heterocyclic group with at least one conjugated substituent. The conjugated substituent can be an electron withdrawing group or electron donating group. The phenanthrene derivatives have semiconductor properties of electron transfer, electroluminescence (EL), and photoluminescence (PL). Intermolecular stacking can be avoided and electron-luminescent emission stability is enhanced when the derivatives are applied as a light-emitting material in organic EL devices due to the presence of the two stereo cyclopentane rings, such as a host compound or a dopant emitting blue light.

Abstract: A handling apparatus for information storage disks includes a conveying apparatus and a mounting base. The conveying apparatus includes a body, a conveying arm, a transmission device and a driving device. The body includes an arm holder. The arm holder has a guide channel. The guide channel includes a transverse passage and a longitudinal passage. The conveying arm is movably mounted in the arm holder and moves along the guide channel. The transmission device connects the driving device to the conveying arm so that the driving device moves the conveying arm in the guide channel. When the conveying arm moves in the transverse passage, the conveying arm has at least one linear self-alignment for positioning.

Abstract: A compact disk feeder includes a base assembly, a disk transportation device and a disk holder. The base assembly includes a casing with a slot. The disk transportation device is mounted in the base assembly and includes a feeding roller rotatably mounted in the casing and partially exposed on the casing. The disk holder demountably is mounted on the base assembly to hold a compact disk stack. Thus, the rotated feeding tray moves the compact disk at the bottom of the compact disk stack through the slot to a new location, such as a tray of a burner or a disk destroying apparatus.

Abstract: A handling apparatus for information storage disks includes a conveying apparatus and a mounting base. The conveying apparatus includes a body, a conveying arm, a transmission device and a driving device. The body includes an arm holder. The arm holder has a guide channel. The guide channel includes a transverse passage and a longitudinal passage. The conveying arm is movably mounted in the arm holder and moves along the guide channel. The transmission device connects the driving device to the conveying arm so that the driving device moves the conveying arm in the guide channel. When the conveying arm moves in the transverse passage, the conveying arm has at least one linear self-alignment for positioning.

Abstract: Methods and apparatus for key distribution in a conditional access system, assuming that the set of all user nodes which the system can accommodate is a complete set, and a subset is composed of all user nodes or part of user nodes. One method comprises: decomposing said subset into at least one secondary subset; assigning a different user key to each secondary subset, each said user key being transmitted to all users in a corresponding secondary subset; encrypting an entitlement key by using each said user key so as to generate a cipher text corresponding to each said secondary subset; and combining said cipher text to generate a media key control block and transmitting said media key control block to all users in said subset. Since a classification method of a binary tree and a multiple tree is used, the invention can save a lot of network resources.

Abstract: A compact disk feeder includes a base assembly, a disk transportation device and a disk holder. The base assembly includes a casing with a slot. The disk transportation device is mounted in the base assembly and includes a feeding roller rotatably mounted in the casing and partially exposed on the casing. The disk holder demountably is mounted on the base assembly to hold a compact disk stack. Thus, the rotated feeding tray moves the compact disk at the bottom of the compact disk stack through the slot to a new location, such as a tray of a burner or a disk destroying apparatus.

Abstract: A phenanthrene compound represented by the formula (I): in which, R1, R2, R3, R4, R5, R6, R7, and R8 are identical or different and may each be hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, or a conjugated group. The phenanthrene compound has a polycyclic structure and semiconductor properties including electron transfer, electroluminescence, and photoluminescence.

Abstract: The present invention discloses a phenanthrene derivative having the following structure: wherein Ar1 and Ar2 independently are phenyl, nathphyl, heterocyclic group, polycyclic aromatic or polycyclic heterocyclic group with at least one conjugated substituent. The conjugated substituent can be an electron withdrawing group or electron donating group. The phenanthrene derivatives have semiconductor properties of electron transfer, electroluminescence (EL), and photoluminescence (PL). Intermolecular stacking can be avoided and electron-luminescent emission stability is enhanced when the derivatives are applied as a light-emitting material in organic EL devices due to the presence of the two stereo cyclopentane rings, such as a host compound or a dopant emitting blue light.

Abstract: A phenanthrene compound represented by the formula (I): in which, R1, R2, R3, R4, R5, R6, R7, and R8 are identical or different and may each be hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, or a conjugated group. The phenanthrene compound has a polycyclic structure and semiconductor properties including electron transfer, electroluminescence, and photoluminescence.

Abstract: Methods and apparatus for key distribution in a conditional access system, assuming that the set of all user nodes which the system can accommodate is a complete set, and a subset is composed of all user nodes or part of user nodes. One method comprises: decomposing said subset into at least one secondary subset; assigning a different user key to each secondary subset, each said user key being transmitted to all users in a corresponding secondary subset; encrypting an entitlement key by using each said user key so as to generate a cipher text corresponding to each said secondary subset; and combining said cipher text to generate a media key control block and transmitting said media key control block to all users in said subset. Since a classification method of a binary tree and a multiple tree is used, the invention can save a lot of network resources.