Patents by Inventor Zonghua Wang

Zonghua Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10978719
    Abstract: A platinum/black phosphorus-carbon sphere methanol fuel cell anode catalyst and preparation method thereof including the following steps: (1) dispersing a black phosphorus solid in an organic solvent to obtain a single or a few layers of black phosphorus dispersion with set concentration; (2) mixing the dispersion with glucose and stirring until dissolved; (3) performing a hydrothermal reaction on the solution to obtain an aqueous solution of the composite material containing a carbon core black phosphorus shell structure; (4) uniformly mixing the aqueous solution with an ethylene glycol solution of sodium chloroplatinate, adjusting the pH, then reducing the platinum on the surface by using a microwave irradiation heating method; and (5) filtering, washing and drying the obtained composite material to obtain a platinum/black phosphorus-carbon sphere composite material.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: April 13, 2021
    Assignee: QINGDAO UNIVERSITY
    Inventors: Feifei Zhang, Zonghua Wang, Zhenyu Wang, Xing Luo, Xiaofang Duan
  • Publication number: 20210102900
    Abstract: An electrogenerated chemiluminescence (ECL) probe is based on trititanium dicarbide two-dimensional (2D) metal carbide catalyzed luminol and a preparation method. The biosensor includes the probe and the electrode of the biosensor, wherein the probe includes the Ti3C2 MXenes nanosheets, a linker molecule and a bio-recognition molecule 1; the Ti3C2 MXenes nanosheets are linked with the linker molecule by electrostatic adsorption; the linker molecule is linked with the bio-recognition molecule 1 by an amide group, contains a primary or secondary amine group, and presents positive potential in water; the bio-recognition molecule 1 is a single-stranded DNA sequence 1 having a carboxyl group at the 5? end, and a CD63 protein on exosomes is recognized by the single-stranded DNA sequence 1. It was found for the first time that Ti3C2 MXenes can improve the ECL signal of luminol, the Ti3C2 MXenes could be applicable to the ECL probe.
    Type: Application
    Filed: November 26, 2018
    Publication date: April 8, 2021
    Applicant: QINGDAO UNIVERSITY
    Inventors: Zonghua WANG, Huixin ZHANG, Yang LIU
  • Publication number: 20210003566
    Abstract: A method for preparing a label-free aptamer electrochemical sensor of ?-interferon based on a dendrimer/gold nanoparticle/molybdenum disulfide nanocomposite is provided. The nanocomposite is drip-coated on a surface of an electrode to prepare a modified electrode, and a terminal sulfhydryl group of a ?-interferon aptamer chain is connected to the gold nanoparticle via Au—S bond to obtain a nanocomposite-aptamer modified electrode. When ?-interferon is present, the ?-interferon specifically binds to the aptamer chain on the sensor, resulting in the aptamer's hairpin structure being opened and stretched, which can effectively adsorb methylene blue MB in the electrolyte, causing significant enhancement of MB redox signal. A linear relationship between a current intensity of MB oxidation peak and a concentration of the ?-interferon is fitted to construct the label-free aptamer electrochemical sensor of ?-interferon.
    Type: Application
    Filed: March 21, 2019
    Publication date: January 7, 2021
    Applicant: Qingdao University
    Inventors: Hui JIN, Xiaohui GAO, Rijun GUI, Zonghua WANG
  • Patent number: 10883984
    Abstract: A method for preparing a label-free aptamer electrochemical sensor of ?-interferon based on a dendrimer/gold nanoparticle/molybdenum disulfide nanocomposite is provided. The nanocomposite is drip-coated on a surface of an electrode to prepare a modified electrode, and a terminal sulfhydryl group of a ?-interferon aptamer chain is connected to the gold nanoparticle via Au—S bond to obtain a nanocomposite-aptamer modified electrode. When ?-interferon is present, the ?-interferon specifically binds to the aptamer chain on the sensor, resulting in the aptamer's hairpin structure being opened and stretched, which can effectively adsorb methylene blue MB in the electrolyte, causing significant enhancement of MB redox signal. A linear relationship between a current intensity of MB oxidation peak and a concentration of the ?-interferon is fitted to construct the label-free aptamer electrochemical sensor of ?-interferon.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: January 5, 2021
    Assignee: QINGDAO UNIVERSITY
    Inventors: Hui Jin, Xiaohui Gao, Rijun Gui, Zonghua Wang
  • Patent number: 10871463
    Abstract: A preparation method based on simultaneous package of a target substance and synthesis of MOFs with redox activity, wherein methylene blue is selected as an organic target molecule, the methylene blue is packaged in the MOFs when the MOFs are synthesized by using a one-pot method to obtain ZIF-8 modified by the methylene blue. The drawback that above-mentioned MOFs material does not have electrical conductivity is overcome, the method is simple, rapid and low in cost, and the prepared product can accurately, sensitively, simply and quickly detect dopamine, and a new development direction is provided for researches in the fields of biological detection and chemical analysis, etc.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: December 22, 2020
    Assignee: QINGDAO UNIVERSITY
    Inventors: Zonghua Wang, Gege Yu, Jianfei Xia, Shida Gong
  • Publication number: 20200112033
    Abstract: A platinum/black phosphorus@carbon sphere methanol fuel cell anode catalyst and preparation method thereof including the following steps: (1) dispersing a black phosphorus solid in an organic solvent to obtain a single or a few layers of black phosphorus dispersion with set concentration; (2) mixing the dispersion with glucose and stirring until dissolved; (3) performing a hydrothermal reaction on the solution to obtain an aqueous solution of the composite material containing a carbon core black phosphorus shell structure; (4) uniformly mixing the aqueous solution with an ethylene glycol solution of sodium chloroplatinate, adjusting the pH, then reducing the platinum on the surface by using a microwave irradiation heating method; and (5) filtering, washing and drying the obtained composite material to obtain a platinum/black phosphorus @carbon sphere composite material.
    Type: Application
    Filed: December 8, 2017
    Publication date: April 9, 2020
    Applicant: QINGDAO UNIVERSITY
    Inventors: Feifei ZHANG, Zonghua WANG, Zhenyu WANG, Xing LUO, Xiaofang DUAN
  • Patent number: 10605761
    Abstract: A electrochemical biosensor based on an aptamer/nano silver probe and an EXO I enzyme. Nano silver nanoparticles having the functions of identifying a target object and generating electrochemical signals and modified by an aptamer are used as a biological probe for detecting target biomolecules, under the initiation of the target object and the assistance of a complementary probe and the EXO I enzyme cyclic shear amplification, and by means of the DNA complementary pairing principle, the probe can be gathered on the surface of a gold electrode, the larger the concentration of the target biomolecules is, the larger the gathering degree of the induced aptamer/nano silver probe is, and meanwhile an EXO I exonuclease target cyclic amplification strategy is introduced in the identification process of the target object, so that the electrochemical biosensor can sensitively and efficiently detect target biological substances.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: March 31, 2020
    Assignee: QINGDAO UNIVERSITY
    Inventors: Jianfei Xia, Xiyue Cao, Zonghua Wang, Hua Sun
  • Publication number: 20180328878
    Abstract: A electrochemical biosensor based on an aptamer/nano silver probe and an EXO I enzyme. Nano silver nanoparticles having the functions of identifying a target object and generating electrochemical signals and modified by an aptamer are used as a biological probe for detecting target biomolecules, under the initiation of the target object and the assistance of a complementary probe and the EXO I enzyme cyclic shear amplification, and by means of the DNA complementary pairing principle, the probe can be gathered on the surface of a gold electrode, the larger the concentration of the target biomolecules is, the larger the gathering degree of the induced aptamer/nano silver probe is, and meanwhile an EXO I exonuclease target cyclic amplification strategy is introduced in the identification process of the target object, so that the electrochemical biosensor can sensitively and efficiently detect target biological substances.
    Type: Application
    Filed: July 14, 2017
    Publication date: November 15, 2018
    Applicant: QINGDAO UNIVERSITY
    Inventors: Jianfei XIA, Xiyue CAO, Zonghua WANG, Hua SUN
  • Publication number: 20180305379
    Abstract: A preparation method based on simultaneous package of a target substance and synthesis of MOFs with redox activity, wherein methylene blue is selected as an organic target molecule, the methylene blue is packaged in the MOFs when the MOFs are synthesized by using a one-pot method to obtain ZIF-8 modified by the methylene blue. The drawback that above-mentioned MOFs material does not have electrical conductivity is overcome, the method is simple, rapid and low in cost, and the prepared product can accurately, sensitively, simply and quickly detect dopamine, and a new development direction is provided for researches in the fields of biological detection and chemical analysis, etc.
    Type: Application
    Filed: July 17, 2017
    Publication date: October 25, 2018
    Applicant: QINGDAO UNIVERSITY
    Inventors: Zonghua WANG, Gege YU, Jianfei XIA, Shida GONG
  • Patent number: 7434996
    Abstract: A C-arm system is disclosed herein. The C-arm system includes a support assembly, and a C-extension connected to the support assembly. The C-extension is selectively rotatable relative to the support assembly in both a clockwise and a counterclockwise direction. The C-arm system also includes a C-gantry connected to the C-extension. The C-gantry is adapted to retain an x-ray source and an x-ray detector. The C-gantry is selectively rotatable relative to the C-extension in both a clockwise and a counterclockwise direction. The C-extension is operable to extend the range of C-gantry rotation in both clockwise and counter clockwise directions. A corresponding method for operating a C-arm system is also provided.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: October 14, 2008
    Assignee: General Electric Co.
    Inventors: Zonghua Wang, Arvidas Bronislavovich Cheryauka
  • Publication number: 20080175354
    Abstract: A C-arm system is disclosed herein. The C-arm system includes a support assembly, and a C-extension connected to the support assembly. The C-extension is selectively rotatable relative to the support assembly in both a clockwise and a counterclockwise direction. The C-arm system also includes a C-gantry connected to the C-extension. The C-gantry is adapted to retain an x-ray source and an x-ray detector. The C-gantry is selectively rotatable relative to the C-extension in both a clockwise and a counterclockwise direction. The C-extension is operable to extend the range of C-gantry rotation in both clockwise and counter clockwise directions. A corresponding method for operating a C-arm system is also provided.
    Type: Application
    Filed: January 19, 2007
    Publication date: July 24, 2008
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Zonghua Wang, Arvi Cheryauka