Patents by Inventor Zongjun SHI

Zongjun SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF
    Publication number: 20240368204
    Abstract: Disclosed is a compound of formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a solvate, a co-crystal or a deuterated product thereof, or a pharmaceutical composition containing same, and the use thereof as a CD73 antagonist in the preparation of a drug for treating related diseases, wherein the definition of each group in formula (I) is consistent with the definition in the description.
    Type: Application
    Filed: May 10, 2022
    Publication date: November 7, 2024
    Inventors: Yao LI, Lei CHEN, Zongjun SHI, Gang HU, Pengxin GENG, Haodong WANG, Shaohui SHI, Yongli WANG, Pingming TANG, Yan YU, Chen ZHANG, Pangke YAN
  • AAK1 INHIBITOR AND USE THEREOF
    Publication number: 20240343720
    Abstract: A compound of formula (I) and a stereoisomer, deuterated compound, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, or a pharmaceutical composition containing same, and the use thereof as an AAK1 inhibitor in the preparation of a drug for treating related diseases.
    Type: Application
    Filed: July 14, 2022
    Publication date: October 17, 2024
    Inventors: Yao Li, Wenjing Wang, Zongjun Shi, Haoliang Zhang, Chenglong Du, Fengkai CHENG, Xin Liu, Xiaozhuan Zhang, Long Wang, Pingming Tang, Yan Yu, Chen Zhang, Pangke Yan
  • ARYLAMINO DERIVATIVE ESTROGEN RECEPTOR MODULATOR AND USE THEREOF
    Publication number: 20240208932
    Abstract: The present invention relates to a compound as represented by formula (I) and a stereoisomer, solvate, deuterated compound or pharmaceutically acceptable salt or pharmaceutical composition thereof, and the use thereof in the preparation of a drug for treating/preventing ER-mediated diseases, wherein each group in formula (I) is as defined in the description.
    Type: Application
    Filed: July 14, 2022
    Publication date: June 27, 2024
    Inventors: Yao LI, Wenjing WANG, Zongjun SHI, Changwei SONG, Lei REN, Jie WANG, Pingming TANG, Yan YU, Chen ZHANG, Pangke YAN
  • NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF
    Publication number: 20240059681
    Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.
    Type: Application
    Filed: September 15, 2023
    Publication date: February 22, 2024
    Applicant: HAISCO PHARMACEUTICALS PTE. LTD.
    Inventors: Yao Li, Zongjun Shi, Guobiao ZHANG, Lei Chen, Wenjing Wang, Xiaobo Zhang, Dengyu Zheng, Bo Xu, Xin Liu, Yajun Wang, Fei Ye, Pingming Tang, Jia Ni, Chen Zhang, Pangke Yan
  • INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF
    Publication number: 20230365541
    Abstract: Disclosed are a compound of formula (I), a stereoisomer, a pharmaceutically acceptable salt, a solvate, and a eutectic or deuterated compound thereof, or a pharmaceutical composition comprising same, and a use thereof as an EZH2 inhibitor in the preparation of a medication for treating related diseases. The definition of each group in formula (I) is consistent with that in the description.
    Type: Application
    Filed: March 15, 2021
    Publication date: November 16, 2023
    Inventors: Yao LI, Zongjun SHI, Guobiao ZHANG, Wenjing WANG, Lei CHEN, Yunpeng PEI, Long YANG, Changwei SONG, Pingming TANG, Fei YE, Chen ZHANG, Jia NI, Pangke YAN
  • Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
    Patent number: 11807635
    Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: November 7, 2023
    Assignee: Haisco Pharmaceuticals Pte. Ltd.
    Inventors: Yao Li, Zongjun Shi, Guobiao Zhang, Lei Chen, Wenjing Wang, Xiaobo Zhang, Dengyu Zheng, Bo Xu, Xin Liu, Yajun Wang, Fei Ye, Pingming Tang, Jia Ni, Chen Zhang, Pangke Yan
  • PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20230265107
    Abstract: The present invention relates to a compound of formula (I); a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt, a co-crystal or a prodrug thereof, or a pharmaceutical composition containing same; and the use thereof as a PB2 inhibitor in the preparation of a drug for treating related diseases. Each group in formula (I) is as defined in the description.
    Type: Application
    Filed: July 9, 2021
    Publication date: August 24, 2023
    Applicant: SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
    Inventors: Yao LI, Lei CHEN, Zongjun SHI, Guobiao ZHANG, Wenjing WANG, Fei YE, Gang HU, Tiancheng HE, Haodong WANG, Jia NI, Chen ZHANG, Pangke YAN
  • NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF
    Publication number: 20230121807
    Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.
    Type: Application
    Filed: October 28, 2022
    Publication date: April 20, 2023
    Applicant: HAISCO PHARMACEUTICALS PTE. LTD
    Inventors: Yao Li, Zongjun Shi, Guobiao ZHANG, Lei Chen, Wenjing Wang, Xiaobo Zhang, Dengyu Zheng, Bo Xu, Xin Liu, Yajun Wang, Fei Ye, Pingming Tang, Jia Ni, Chen Zhang, Pangke Yan
  • ANTI-INFLUENZA VIRUS COMPOUND, PREPARATION METHOD AND USE THEREOF
    Publication number: 20230079045
    Abstract: Provided are a compound of formula (I-a), an isomer thereof or a pharmaceutically acceptable salt thereof as a Hemagglutinin inhibitor, and a preparation method thereof. The compound is useful for preparing a medicament for treating a disease related to Hemagglutinin.
    Type: Application
    Filed: August 24, 2020
    Publication date: March 16, 2023
    Applicant: Sichuan Haisco Pharmaceutical Co., Ltd.
    Inventors: Yao Li, Lei Chen, Guobiao Zhang, Wenjing Wang, Zongjun Shi, Gang Hu, Haitao Huang, Haodong Wang, Bo Xu, Xiaobo Zhang, Guoliang LIU, Dengyu Zheng, Shilin Huang, Jianfei Zhao, Changwei Song, Chen Zhang, Fei Ye, Jia Ni, Pangke Yan
  • NITROGEN-CONTAINING HETEROCYCLIC AUTOTAXIN INHIBITOR, AND COMPOSITION CONTAINING SAME AND USE THEREOF
    Publication number: 20230069174
    Abstract: Disclosed are a nitrogen-containing heterocyclic compound as shown in formula (I), or a stereoisomer, a solvate, a deuterated form, a pharmaceutically acceptable salt, or a cocrystal thereof or a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for treating/preventing diseases mediated by autotaxin. Each group in formula (I) is as defined in the description.
    Type: Application
    Filed: December 10, 2020
    Publication date: March 2, 2023
    Inventors: Yao LI, Zongjun SHI, Wenjing WANG, Yongli WANG, Yunpeng PEI, Changwei SONG, Yonghong LI, Pingming TANG, Yan YU, Chen ZHANG, Jia NI, Pangke YAN
  • Fused tricyclic ?-amino acid derivative, preparation method therefor, and medical use thereof
    Patent number: 10654794
    Abstract: Disclosed are a fused tricyclic ?-amino acid derivative and a medical use thereof, in particular, the present invention relates to a fused cyclic ?-amino acid derivative as shown in general formula (I), or a stereoisomer, solvate, metabolite, prodrug, pharmaceutically acceptable salt or eutectic thereof, a pharmaceutical composition containing same, and the use of a compound or the composition in the field of analgesia, wherein the definitions of each substituent in general formula (I) are the same as the definitions in the description.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: May 19, 2020
    Assignee: SICHUAN HAISO PHARMACEUTICAL CO., LTD.
    Inventors: Yao Li, Zongjun Shi, Bo Xu
  • FUSED TRICYCLIC GAMMA-AMINO ACID DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Publication number: 20190218172
    Abstract: Disclosed are a fused tricyclic ?-amino acid derivative and a medical use thereof, in particular, the present invention relates to a fused cyclic ?-amino acid derivative as shown in general formula (I), or a stereoisomer, solvate, metabolite, prodrug, pharmaceutically acceptable salt or eutectic thereof, a pharmaceutical composition containing same, and the use of a compound or the composition in the field of analgesia, wherein the definitions of each substituent in general formula (I) are the same as the definitions in the description.
    Type: Application
    Filed: September 12, 2017
    Publication date: July 18, 2019
    Applicant: SICHUAN HAISO PHARMACEUTICAL CO., LTD.
    Inventors: Yao LI, Zongjun SHI, Bo XU