Patents by Inventor Zongyi YI

Zongyi YI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250108134
    Abstract: Provided are methods of treating a disease or condition by administering a circular RNA (circRNA) encoding a therapeutic polypeptide (e.g., an antigenic polypeptide, a functional protein, a receptor protein, or a targeting protein (e.g., antibody)), wherein the circRNA is naked; and pharmaceutical composition(s) comprising the circRNA(s) as disclosed herein.
    Type: Application
    Filed: January 28, 2023
    Publication date: April 3, 2025
    Inventors: Wensheng WEI, Yong SHEN, Liang QU, Feng CHEN, Zongyi YI
  • Publication number: 20250082746
    Abstract: Provided are circular RNAs (circRNAs) encoding an antigenic polypeptide of a SARS-CoV-2 variant. Provided are circRNA vaccines against a SARS-CoV-2 variant, such as a Delta or Omicron variant. The circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike(S) protein or a fragment thereof of a SRAS-CoV-2 variant. Also provided are methods of treating or preventing a SARS-CoV-2 infection using the circRNAs or compositions thereof.
    Type: Application
    Filed: January 9, 2023
    Publication date: March 13, 2025
    Applicant: Peking University
    Inventors: Wensheng WEI, Liang QU, Zongyi YI, Yong SHEN, Liangru LIN, Feng CHEN
  • Publication number: 20250051816
    Abstract: The present application provides methods for producing circular RNAs (circRNAs) from a DNA construct encoding a linear RNA precursor, wherein the linear RNA precursor comprises from the 5?-end to the 3? end: a 3? catalytic Group I intron fragment, a 3? exon sequence, an effector RNA sequence, a 5? exon sequence, and a 5? catalytic Group I intron fragment, wherein the method comprises an in vitro single-pot reaction. In some embodiments, the single-pot reaction does not comprise supplementing the reagent composition with GTP, a divalent metal ion such as Mg2+, or DNase I prior to circularization of a linear RNA precursor.
    Type: Application
    Filed: March 22, 2022
    Publication date: February 13, 2025
    Inventors: Wensheng WEI, Liang QU, Zongyi YI, Yong SHEN
  • Publication number: 20250001011
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, methods for reducing off-target editing of RNA, deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.
    Type: Application
    Filed: August 18, 2022
    Publication date: January 2, 2025
    Inventors: Wensheng WEI, Zongyi YI, Pengfei YUAN
  • Publication number: 20240309368
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. Further provided are deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.
    Type: Application
    Filed: January 12, 2021
    Publication date: September 19, 2024
    Inventors: Wensheng WEI, Zongyi YI, Liang QU
  • Publication number: 20240247265
    Abstract: The present application provides linear RNA precursors and constructs for preparing circular RNAs (circRNAs) comprising an effector RNA sequence, such as a coding RNA sequence. In some embodiments, the linear RNA comprises from the 5? end to the 3? end: (a) a first portion of an RNA element (e.g., an IRES), (b) an effector RNA sequence, and (c) a second portion of the RNA element, wherein the first and the second portions of the RNA element associate with each other to form a double-stranded region of at least 4 basepairs long, wherein the 5? end of the first portion of the RNA element and the 3? end of the second portion of the RNA element form a nick in the double-stranded region, and wherein an RNA ligase can ligate the nick. Also provided are methods of preparing circRNAs, circRNAs prepared thereof, and methods of using the circRNAs.
    Type: Application
    Filed: February 26, 2024
    Publication date: July 25, 2024
    Applicant: Peking University
    Inventors: Wensheng WEI, Zongyi YI
  • Publication number: 20230365962
    Abstract: The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions and kits comprising the same.
    Type: Application
    Filed: April 19, 2023
    Publication date: November 16, 2023
    Inventors: Wensheng Wei, Zongyi Yi, Liang Qu, Feng Tian, Chunhui Wang, Shiyou Zhu, Zhuo Zhou
  • Publication number: 20230346921
    Abstract: The present application provides circular RNAs (circRNAs) encoding therapeutic polyeptides (e.g., an antigenic polypeptide, a functional protein, a receptor protein, or a targeting protein). In some embodiments, the present application provides circRNA vaccines against a coronavirus such as SARS-CoV-2. In some embodiments, the circRNA vaccine comprises a circRNA comprising a nucleic acid sequence encoding an antigenic polypeptide comprising a Spike (S) protein or a fragment thereof of a coronavirus. Also provided are methods of treating or preventing a disease or condition using the circRNAs or compositions thereof.
    Type: Application
    Filed: August 20, 2021
    Publication date: November 2, 2023
    Inventors: Wensheng WEI, Liang QU, Zongyi YI
  • Patent number: 11702658
    Abstract: The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: July 18, 2023
    Assignees: EDIGENE THERAPEUTICS (BEIJING) INC., PEKING UNIVERSITY
    Inventors: Pengfei Yuan, Yanxia Zhao, Nengyin Liu, Zexuan Yi, Gangbin Tang, Wensheng Wei, Liang Qu, Zongyi Yi, Shiyou Zhu, Chunhui Wang, Zhongzheng Cao, Zhuo Zhou
  • Patent number: 11661596
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: May 30, 2023
    Assignee: PEKING UNIVERSITY
    Inventors: Wensheng Wei, Zongyi Yi, Liang Qu, Feng Tian, Chunhui Wang, Shiyou Zhu, Zhuo Zhou
  • Publication number: 20220307020
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. Further provided are deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
    Type: Application
    Filed: April 15, 2020
    Publication date: September 29, 2022
    Inventors: Pengfei YUAN, Yanxia ZHAO, Nengyin LIU, Zexuan YI, Gangbin TANG, Wensheng WEI, Liang QU, Zongyi YI, Shiyou ZHU, Chunhui WANG, Zhongzheng CAO, Zhuo ZHOU
  • Publication number: 20220243194
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 4, 2022
    Applicant: PEKING UNIVERSITY
    Inventors: Wensheng WEI, Zongyi YI, Liang QU, Feng TIAN, Chunhui WANG, Shiyou ZHU, Zhuo ZHOU
  • Publication number: 20220135963
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.
    Type: Application
    Filed: January 11, 2022
    Publication date: May 5, 2022
    Applicant: PEKING UNIVERSITY
    Inventors: Wensheng WEI, Zongyi YI, Liang QU, Feng TIAN, Chunhui WANG, Shiyou ZHU, Zhuo ZHOU
  • Publication number: 20220098587
    Abstract: The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
    Type: Application
    Filed: October 14, 2021
    Publication date: March 31, 2022
    Inventors: Pengfei YUAN, Yanxia ZHAO, Nengyin LIU, Zexuan YI, Gangbin TANG, Wensheng WEI, Liang QU, Zongyi YI, Shiyou ZHU, Chunhui WANG, Zhongzheng CAO, Zhuo ZHOU
  • Publication number: 20210355494
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, and deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
    Type: Application
    Filed: October 12, 2019
    Publication date: November 18, 2021
    Inventors: Wensheng WEI, Liang QU, Zongyi YI, Shiyou ZHU, Chunhui WANG, Zhongzheng CAO, Zhuo ZHOU, Pengfei YUAN
  • Publication number: 20210310026
    Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, and deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 7, 2021
    Inventors: Wensheng WEI, Liang QU, Zongyi YI, Shiyou ZHU, Chunhui WANG, Zhongzheng CAO, Zhuo ZHOU, Pengfei YUAN