Abstract: Systems, devices, and methods for analyzing clinical trial data by storing the clinical trial data in a trial monitoring data object; using multiple metric functions to generate multiple metric values that each indicate a statistical attribute of a variable of a patient; creating an analytical data object that stores the metric values and contents of the trial monitoring object; determining, for each metric function “f” and each variable “v”, a risk score Sf,v(u) associated with each clinical unit “u”; creating a risk data object that stores the risk scores “Sf,v(u)” and contents of the analytical data object; and displaying a graphical user interface that permits a user to visualize and recognize patterns in the data by interacting with a three-dimensional matrix that selectively displays markers for risk scores based on a risk threshold, where selecting a marker corresponding to a risk score allows for further investigation of the corresponding unit.