Patents by Inventor Zorica Marusic-Istuk
Zorica Marusic-Istuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11512096Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.Type: GrantFiled: December 24, 2020Date of Patent: November 29, 2022Assignee: SELVITA D.O.O.Inventors: Andrea Fajdetic, Maja Matanovic Skugor, Ivaylo Jivkov Elenkov, Goran Kragol, Mirjana Bukvic, Zorica Marusic Istuk, Sanja Kostrun, Dinko Ziher, Renata Rupcic, Kristina Butkovic, Marko Duksi, Ivana Ozimec Landek, Dijana Pesic, Antun Hutinec, Milan Mesic, Gordon Saxty, Visnja Poljak
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Publication number: 20210198278Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.Type: ApplicationFiled: December 24, 2020Publication date: July 1, 2021Inventors: Andrea FAJDETIC, Maja MATANOVIC SKUGOR, Ivaylo Jivkov ELENKOV, Goran KRAGOL, Mirjana BUKVIC, Zorica MARUSIC ISTUK, Sanja KOSTRUN, Dinko ZIHER, Renata RUPCIC, Kristina BUTKOVIC, Marko DUKSI, Ivana OZIMEC LANDEK, Dijana PESIC, Antun HUTINEC, Milan MESIC, Gordon SAXTY, Visnja POLJAK
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Patent number: 10919910Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.Type: GrantFiled: May 8, 2017Date of Patent: February 16, 2021Assignee: FIDELTA D.O.O.Inventors: Andrea Fajdetic, Maja Matanovic Skugor, Ivaylo Jivkov Elenkov, Goran Kragol, Mirjana Bukvic, Zorica Marusic Istuk, Sanja Kostrun, Dinko Ziher, Renata Rupcic, Kristina Butkovic, Marko Duksi, Ivana Ozimec Landek, Dijana Pesic, Antun Hutinec, Milan Mesic, Gordon Saxty, Visnja Poljak
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Publication number: 20200017522Abstract: The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.Type: ApplicationFiled: May 8, 2017Publication date: January 16, 2020Inventors: Andrea FAJDETIC, Maja MATANOVIC SKUGOR, Ivaylo Jivkov ELENKOV, Goran KRAGOL, Mirjana BUKVIC, Zorica MARUSIC ISTUK, Sanja KOSTRUN, Dinko ZIHER, Renata RUPCIC, Kristina BUTKOVIC, Marko DUKSI, Ivana OZIMEC LANDEK, Dijana PESIC, Antun HUTINEC, Milan MESIC, Gordon SAXTY, Visnja POLJAK
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Patent number: 8227428Abstract: The compound 3?-N-demethyl-4?-O-(2-diethylaminoethanoyl)-6-O-methyl-9a-aza-9a-homoerythromycin A, having the Formula (I): or a salt thereof, compositions comprising the compound, its use in the treatment of neutrophil dominated inflammatory diseases, and methods for its preparation.Type: GrantFiled: January 28, 2010Date of Patent: July 24, 2012Assignee: Glaxo Group LimitedInventors: Caroline Jane Day, Julien Bruno Douillet, Darko Filic, Leanda Jane Kindon, Goran Kragol, Zorica Marusic-Istuk
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Publication number: 20120058963Abstract: The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4? position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-?, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.Type: ApplicationFiled: November 15, 2011Publication date: March 8, 2012Applicant: Glaxo Group LimitedInventors: Sulejman Alihodzic, Martina Bosnar, Ognjen Culic, Vesna Erakovic Haber, Antun Hutinec, Dubravko Jelic, Goran Kragol, Nikola Marjanovic, Zorica Marusic-Istuk, Marija Ribic, Vanja Vela
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Patent number: 8080529Abstract: The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4? position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-?, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.Type: GrantFiled: January 13, 2006Date of Patent: December 20, 2011Assignee: Glaxo Group LimitedInventors: Sulejman Alihodzic, Martina Bosnar, Ognjen Culic, Vesna Erakovic Haber, Antun Hutinec, Dubravko Jelic, Goran Kragol, Nikola Marjanovic, Zorica Marusic-Istuk, Marija Ribic, Vanja Vela
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Patent number: 7910559Abstract: The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-?, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.Type: GrantFiled: January 13, 2006Date of Patent: March 22, 2011Assignee: GlaxoSmithKline istrazivacki centar Zagreb d.o.o.Inventors: Ognjen Culic, Martina Bosnar, Sulejman Alihodzic, Gorjana Lazarevski, Zorica Marusic Istuk, Antun Hutinec, Vanja Vela, Goran Kragol
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Publication number: 20110039795Abstract: Novel 2?-O,3?-N-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2?-O,3?-N-bridged 14-membered macrolides and to 2?-O,3?-N-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.Type: ApplicationFiled: April 20, 2009Publication date: February 17, 2011Inventors: Mirjana Bukvic-Krajacic, Antun Hutinec, Goran Kragol, Nedjeljko Kujundzic, Zorica Marusic-Istuk
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Publication number: 20100197623Abstract: The compound 3?-N-demethyl-4?-O-(2-diethylaminoethanoyl)-6-O-methyl-9a-aza-9a-homoerythromycin A, having the Formula (I): or a salt thereof, compositions comprising the compound, its use in the treatment of neutrophil dominated inflammatory diseases, and methods for its preparation.Type: ApplicationFiled: January 28, 2010Publication date: August 5, 2010Inventors: Caroline Jane Day, Julien Bruno Douillet, Darko Filic, Leanda Jane Kindon, Goran Kragol, Zorica Marusic-Istuk
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Publication number: 20080234211Abstract: The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-?, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.Type: ApplicationFiled: January 13, 2006Publication date: September 25, 2008Applicant: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.Inventors: Ognjen Culic, Martina Bosnar, Sulejman Alihodzic, Gorjana Lazarevski, Zorica Marusic Istuk, Antun Hutinec, Vanja Vela, Goran Kragol
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Publication number: 20080221046Abstract: The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4? position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-?, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.Type: ApplicationFiled: January 13, 2006Publication date: September 11, 2008Inventors: Ognjen Culic, Martina Bosnar, Nikola Marjanovic, Dubravko Jelic, Sulejman Alihodzic, Vanja Vela, Zorica Marusic-Istuk, Vesna Erakovic, Berislav Bosnjak, Boska Hrvacic, Marija Tomaskovic, Vanesa Munic, Vanesa Ivetic, Antun Hutinec, Goran Kragol, Marija Leljak
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Patent number: 7262172Abstract: The invention relates to novel semi-synthetic macrolides of formula (I) having antibacterial activity.Type: GrantFiled: October 19, 2001Date of Patent: August 28, 2007Assignees: Glaxo Group Limited, GlaxoSmithKline istrazivacki center Zagret d.o.o.Inventors: Suleman Alihodzic, Andrea Berdik, Francesca Cardullo, Antun Hutinec, Gorjana Lazarevski, Sergio Lociuro, Zorica Marusic-Istuk, Stjepan Mutak, Alfonso Pozzan, Marko Derek
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Patent number: 7202221Abstract: The present invention relates to 14 or 15 membered macrolides substituted at the 4? position of formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal bodyType: GrantFiled: November 13, 2002Date of Patent: April 10, 2007Assignees: Glaxo Group Limited, Pliva D.D.Inventors: Suleman Alihodzic, Daniele Andreotti, Andrea Berdik, Ilaria Bientinesi, Stefano Biondi, Manuela Ciraco, Federica Damiani, Marko Djerek, Miljenko Dumic, Vesna Erakovic, Antun Hutinec, Gorjana Lazarevski, Sergio Lociuro, Natasa Marsic, Zorica Marusic-Istuk, Stjepan Mutak, Alfredo Paio, Drazen Pavlovic, Anna Quaglia, Wolfgang Schoenfeld, Vlado Stimac, Jessica Tibasco
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Publication number: 20070066544Abstract: The present invention relates to the new 3-decladinosyl derivatives of 9a-N-carbamoyl- and 9a-N-thiocarbamoyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A of the general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, to intermediates for synthesis of other macrolide compounds with antibacterial activity, to the process for their preparation, to their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, to the process for the preparation of pharmaceutical compositions, as well as the use of pharmaceutical compositions for treating bacterial infections.Type: ApplicationFiled: May 11, 2004Publication date: March 22, 2007Applicant: GlaxoSmithKline Istrazivacki centar Zagreb d.o.o.Inventors: Zorica Marusic-Istuk, Nedjeljko Kujundzic, Stjepan Mutak
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Publication number: 20050080025Abstract: The present invention relates to 14 or 15 membered macrolides substituted at the 4th position of formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.Type: ApplicationFiled: November 13, 2002Publication date: April 14, 2005Inventors: Suleman Alihodzic, Daniele Andretoh, Andrea Berdik, Ilaria Bientinesi, Stefano Biondi, Manuela Ciraco, Federica Damiani, Marko Djerek, Miljenko Dumic, Vesna Erakovic, Antun Hutinec, Gorjana Lazarevski, Sergio Lociuro, Natasa Marsic, Zorica Marusic-Istuk, Stjepan Mutak, Alfred Paio, Drazen Pavlovic, Anna Quaglia, Wolfgang Schoenfeld, Vlado Stimac, Jessica Tibasco