Patents by Inventor Zsuzsanna Szent-Kirallyi

Zsuzsanna Szent-Kirallyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing pharmaceutical compounds and intermediate compounds
    Patent number: 9169265
    Abstract: The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: October 27, 2015
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Márta Porcs-Makkay, Balázs Volk, Tamás Gregor, József Barkóczy, Tibor Mezei, Judit Broda, Bálint Nyulasi, György Ruzsics, Enikö Molnár, József Debreczeni, Kálmán Nagy, Angéla Pandur, Zsuzsanna Szent-Királlyi
  • Crystalline form I rosuvastatin zinc salt
    Patent number: 9023838
    Abstract: The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 5, 2015
    Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe
    Inventors: Ferenc Bartha, Gyoergyi Kovanyine Lax, Balazs Volk, Jozsef Barkoczy, Gyoergy Morovjan, Gyoergy Krasznai, Kalman Nagy, Gyula Simig, Gyoergy Ruzsics, Gyoergy Clementis, Imre Kapui, Peter Slegel, Adrienn Keszthelyi, Zsuzsanna Szent-Kirallyi, Valeria Hoffmanne Fekete, Janos Imre
  • PROCESS FOR PREPARING PHARMACEUTICAL COMPOUNDS AND INTERMEDIATE COMPOUNDS
    Publication number: 20120330018
    Abstract: The object of the present invention is a process for preparing the 2-acetoxy-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-tieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts form crystalline 5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.
    Type: Application
    Filed: December 21, 2010
    Publication date: December 27, 2012
    Applicant: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Márta Porcs-Makkay, Balázs Volk, Tamás Gregor, József Barkóczy, Tibor Mezei, Judit Broda, Bálint Nyulasi, György Ruzsics, Enikõ Molnár, József Debreczeni, Kálmán Nagy, Angéla Pandur, Zsuzsanna Szent-Királlyi
  • CRYSTALLINE FORM I ROSUVASTATIN ZINC SALT
    Publication number: 20120178729
    Abstract: The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.
    Type: Application
    Filed: July 24, 2009
    Publication date: July 12, 2012
    Inventors: Feren Bartha, Gyoergyi Kovanyine Lax, Balazs Volk, Jozsef Barkoczy, Gyoergy Morovjan, Gyoergy Krasznal, Kalman Nagy, Gyula Simig, Gyoergy Ruzsics, Gyoergy Clementis, Imre Kapui, Peter Slegel, Adrienn Keszthelyi, Zsuzsanna Szent-Kirallyi, Valeria Hoffmanne Fekete, Janos Imre
  • Process for the preparation of olanzapine
    Patent number: 7981884
    Abstract: The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno[2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: July 19, 2011
    Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Györgyi Kovanyine Lax, Gábor Nemeth, György Krasznay, Norbert Mesterhazy, Kálmán Nagy, Györgyi Vereczkeyné Donáth, Zsuzsanna Szent-Kirallyi
  • PROCESS FOR THE PREPARTION OF OLANZAPINE
    Publication number: 20090137563
    Abstract: The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno [2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound.
    Type: Application
    Filed: November 10, 2006
    Publication date: May 28, 2009
    Inventors: Gyorgyi Kovanyine Lax, Gabor Nemeth, Gyorgy Krasznay, Norbert Mesterhazy, Kalman Nagy, Gyorgyi Vereczkeyne Donath, Zsuzsanna Szent-Kirallyi
  • Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
    Patent number: 7396931
    Abstract: The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I)
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: July 8, 2008
    Assignee: Egis Gyógyszergyár Rt.
    Inventors: Péter Kótay Nagy, Gyula Simig, József Barkóczy, Tamás Gregor, Béla Farkas, Györgyi Vereczkeyné Donáth, Kálmán Nagy, Gyuláné Körtvélyessy, Zsuzsanna Szent-Királlyi
  • Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug
    Publication number: 20070142637
    Abstract: The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I).
    Type: Application
    Filed: June 30, 2004
    Publication date: June 21, 2007
    Applicant: EGIS GYOGYSZERGYAR RT.
    Inventors: Gyorgyi Vereczkeyne Donath, Kalman Nagy, Gyulane Kortvelyessy, Zsuzsanna Szent-Kirallyi, Peter Kotay Nagy, Gyula Simig, Jozsef Barkoczy, Tamas Gregor, Bela Farkas
  • Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
    Publication number: 20070117837
    Abstract: The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I).
    Type: Application
    Filed: June 30, 2004
    Publication date: May 24, 2007
    Applicant: EGIS GYOGYSZERGYAR RT.
    Inventors: Peter Kotay Nagy, Gyula Simig, Jozsef Barkoczy, Tamas Gregor, Bela Farkas, Gyorgyi Vereczekeyne Donath, Kalman Nagy, Gyulane Kortvelyessy, Zsuzsanna Szent-Kirallyi