Patents by Inventor Zu-Cheng Ye

Zu-Cheng Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6197820
    Abstract: The present invention describes impaired glutamate uptake in glioma cells, and further shows that instead of removing glutamate from the extracellular fluid, glioma cells release large amounts of glutamate. The high levels of extracellular glutamate result in elevated [Ca2+]i followed by widespread neuronal death, which could be prevented by treating neurons with the NMDA receptor antagonists, MK-801 or D-AP5, or by depletion of glutamate from the medium. Significantly, several phenylglycine derivatives, including the metabotropic glutamate receptor agonist/antagonist (S)-4-carboxyphenylglycine (S-4CPG), potently and selectively inhibited glutamate release from glioma cells and thereby prevented neurotoxicity.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: March 6, 2001
    Assignee: UAB Research Foundation
    Inventors: Harald J. Sontheimer, Zu-Cheng Ye
  • Patent number: 6013672
    Abstract: Astrocytes protect neurons from excitotoxic injury by maintaining low extra-cellular glutamate concentrations ([Glu].sub.o). Compromised astrocytic glutamate uptake has been implicated in acute and chronic neurological conditions, including Parkinson's disease. This invention provides evidence that [Glu].sub.o is modulated in a feed-back manner through activation of metabotropic glutamate receptors (mGluRs), particularly group II mGluRs. Furthermore, ACPD effects were mimicked by glutamate, suggesting that astrocytic glutamate transport is dynamically regulated with mGluRs acting as sensors for changes in [Glu]. Consequently, agonists of mGluR receptors are potent drugs to modulate extracellular glutamate levels in ways that are neuroprotective.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: January 11, 2000
    Assignee: UAB Research Foundation
    Inventors: Zu-Cheng Ye, Harald W. Sontheimer