Abstract: The present disclosure relates to the treatment of neurological conditions, by inhibiting Chk2 kinase. Particular neurological conditions may be associated with neuronal damage/dysfunction or neurological degeneration, which may result from, physical trauma, chemical means, infection, inflammation, hypoxia and/or interruption in blood supply, or be due to a neurodegenerative disorder and/or autoimmune disease. The Chk2 inhibitor may be a small molecule, protein, peptide or nucleic acid. Exemplary small molecule Chk2 inhibitors include PV1019, AZD7762, CCT241533, BML-277 or prexasertib.

Abstract: The present disclosure relates to the treatment of eye conditions, by inhibiting Chk2 kinase. Particular ocular conditions may be associated with neuronal damage/dysfunction in the eye, or neurons in communication with the eye, which may result from, physical trauma, chemical means, infection, inflammation, hypoxia and/or interruption inblood supply, or be due to a neurodegenerative disorder and/or autoimmune disease. The Chk2 inhibitor may be a small molecule, protein, peptide or nucleic acid. Exemplary small molecule Chk2 inhibitors include PV1019, AZD7762, CCT241533, BML-277 or prexasertib.

Abstract: Described are methods for processing microelectronic device substrates by a lapping step, e.g., a final lapping step, wherein the step includes the use of an elastomeric pressure-sensitive adhesive to secure the microelectronic device substrate to a carrier that holds the substrate to a surface of the carrier during the lapping step, and wherein the pressure-sensitive adhesive can be a non-polysilicone based adhesive having mechanical properties that include a tan delta that is below about 0.2.

Abstract: Described are methods for processing microelectronic device substrates by a lapping step, e.g., a final lapping step, wherein the step includes the use of an elastomeric pressure-sensitive adhesive to secure the microelectronic device substrate to a carrier that holds the substrate to a surface of the carrier during the lapping step, and wherein the pressure-sensitive adhesive can be a non-polysilicone based adhesive having mechanical properties that include a tan delta that is below about 0.2.

Abstract: The use of a single compound or a combination of compounds which selectively inhibit both matrix metalloproteinases MMP-9 and MMP-12 in treating spinal cord injury (SCI), the secondary effects of SCI and related injury to neurological tissue are described, in particular the suppression of SCI-induced oedema, treatment of neuropathic pain, the prevention of functional decline following SCI and methods of administration.

Abstract: Methods and systems for monitoring operation of hybrid electric engines of aircraft. The methods include monitoring a motor condition of an electrical power system associated with an engine condition using a motor sensor, wherein the electrical power system comprises an electric machine operably coupled to at least one shaft of an engine core, wherein the electric machine is configured to at least one of add power to the at least one shaft and extract power from the at least one shaft, receiving motor data from the motor sensor at a motor controller, wherein the motor controller is configured to control operation of, at least, the electric machine, analyzing the motor data to determine the presence of a fault in the engine core, and, when a fault is detected, performing a fault response action.

Abstract: A turbine engine includes integrated electric machines in the compressor section and the turbine section to supplement power produced from fuel with electric power. The example compressor section includes a compressor electric motor that is coupled to a compressor generator. The example turbine section includes a turbine electric motor that is coupled to the geared architecture to supplement power driving the fan section. A turbine generator provides electric power to the turbine electric motor.

Abstract: A method for active bi-directional control of an outer structure of a gas turbine engine comprises sending, by a controller, a first control signal to a power electronics for varying an electric current supplied to a heating element to cause the outer structure to move in a first radial direction, and sending, by the controller, a second control signal to a valve assembly for varying a cooling air flow supplied to the outer structure to cause the outer structure to move in a second radial direction. The first radial direction is opposite the second radial direction.

Abstract: A system of a hybrid aircraft includes a first gas turbine engine, a second gas turbine engine, a power source, and a controller. The first gas turbine engine includes a first electric machine. The second gas turbine engine includes a second electric machine. The controller is operable to determine an operating condition of the first gas turbine engine and the second gas turbine engine and to detect a change in a thrust command for the hybrid aircraft. The controller is further operable to determine an adjustment to the second electric machine to compensate for the change in the thrust command while the first gas turbine engine is operating in a fuel-driven mode and the second gas turbine engine is operating in an electrically-driven mode. At least a portion of electric power to perform the adjustment to the second electric machine is extracted from the power source.

Abstract: A hybrid-electric aircraft system is provided and includes first and second hybrid-electric engines, each of which includes an electric motor to drive operations thereof, and a supplemental power unit (SPU). The SPU is configured as a thermal engine paired with a generator and is configured to generate electrical power. The first and second hybrid-electric engines are operable normally and off, respectively, with electrical power generated by the SPU being diverted to the electric motor of the second hybrid-electric engine.

Abstract: A turbine engine includes integrated electric machines in the compressor section and the turbine section to supplement power produced from fuel with electric power. The example compressor section includes a compressor electric motor that is coupled to a compressor generator. The example turbine section includes a turbine electric motor that is coupled to the geared architecture to supplement power driving the fan section. A turbine generator provides electric power to the turbine electric motor.

Abstract: A power system of an aircraft includes a hybrid energy storage system with at least two energy storage subsystems each having a different power-energy density. The power system also includes one or more electric motors operably coupled to the hybrid energy storage system and to an aircraft engine. The power system further includes a means for controlling one or more electric power flows of the hybrid energy storage system to/from the one or more electric motors based on a modeled electric power demand associated with an engine load of one or more spools of the aircraft engine.

Abstract: A gas turbine engine for an aircraft comprising an engine core comprising a turbine, a compressor, and a core shaft connecting the turbine to the compressor; a fan located upstream of the engine core, the fan comprising a plurality of fan blades; a gearbox that receives an input from the core shaft and outputs drive to the fan so as to drive the fan at a lower rotational speed than the core shaft, and a front mount and a rear mount, the front and rear mounts being configured to connect the gas turbine engine to the aircraft, wherein the front mount is coupled to a casing of the engine core and the front mount is located at substantially the same axial position as a centre of gravity (CG) of the gas turbine engine or forward of the centre of gravity of the gas turbine engine.

Abstract: An engine system of an aircraft includes an energy storage system, a gas turbine engine, and a controller. The gas turbine engine includes a low spool, a high spool, a low-spool generator operably coupled to the low spool, and a high-spool electric motor operably coupled to the high spool. The controller is configured to detect a braking condition of the aircraft, transfer power from the low-spool generator to the energy storage system based on the storage capacity state of the energy storage system, and transfer power to the high spool through the high-spool electric motor to support combustion in the gas turbine engine while a rotational speed of the low spool is reduced responsive to the low-spool generator extracting energy from the low spool.

Abstract: A clearance control system for a gas turbine engine may include a rotor blade, an outer structure disposed radially outward from the rotor blade, a heating element, a hybrid electric power source, and a controller. The heating element is configured to cause the outer structure to be heated in response to electric current being supplied to the heating element. A gap between the rotor blade and the outer structure is at least one of increased, decreased, and maintained in response to the outer structure being heated. The hybrid electric power source is configured to supply the electric current to the heating element. The controller is configured to regulate the electric current being supplied to the heating element.

Abstract: A power system of an aircraft includes a hybrid energy storage system with at least two energy storage subsystems each having a different power-energy density, power draw characteristics and/or dissimilar configuration. A primary power unit includes an aircraft engine coupled to an electric motor and a first generator. A secondary power unit is coupled to a second generator. A bidirectional power converter is coupled to the hybrid energy storage system and one or more controllers of the electric motor, the first generator, and the second generator. A power management controller is configured to interface with the hybrid energy storage system and the one or more controllers of the electric motor, the first generator, and the second generator and perform a model predictive control to dynamically adjust one or more electric power flows through the bidirectional power converter based on an engine propulsion power demand of the aircraft engine.

Abstract: A power system of an aircraft includes a hybrid energy storage system with at least two energy storage subsystems each having a different power-energy density, power draw characteristics and/or dissimilar configuration. A primary power unit includes an aircraft engine coupled to an electric motor and a first generator. A secondary power unit is coupled to a second generator. A bidirectional power converter is coupled to the hybrid energy storage system and one or more controllers of the electric motor, the first generator, and the second generator. A power management controller is configured to interface with the hybrid energy storage system and the one or more controllers of the electric motor, the first generator, and the second generator and perform a model predictive control to dynamically adjust one or more electric power flows through the bidirectional power converter based on an engine propulsion power demand of the aircraft engine.

Abstract: A turbine engine includes integrated electric machines in the compressor section and the turbine section to supplement power produced from fuel with electric power. The compressor section includes a compressor electric motor that is electrically coupled to a compressor generator. The example turbine section includes a turbine electric motor that is coupled to a geared architecture to supplement power driving the fan section. A turbine generator driven by a portion of the turbine section provides electric power to the turbine electric motor.

Abstract: A turbine engine includes integrated electric machines in the compressor section and the turbine section to supplement power produced from fuel with electric power. The example compressor section includes a compressor electric motor that is coupled to a compressor generator. The example turbine section includes a turbine electric motor that is coupled to the geared architecture to supplement power driving the fan section. A turbine generator provides electric power to the turbine electric motor.

Abstract: A gas turbine engine includes a generator that is configured to be driven by a turbine section, an electric motor that is configured to receive at least a portion of electric power from the generator, a gearbox that is mechanically coupled to both the electric motor and the generator, and a control system that has an operational amplifier that is configured to synchronize operation of the electric motor and the generator. The operational amplifier electrically couples the electric motor to the generator and is configured to define an electrical gain that matches a mechanical gain that is defined by the gearbox.