Patents by Inventor Zuchun Zhao

Zuchun Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
    Publication number: 20100087465
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
    Type: Application
    Filed: August 14, 2009
    Publication date: April 8, 2010
    Inventors: Xin Chen, Peng Cheng, L. Edward Clemens, Jeffrey D. Johnson, Jingyuan Ma, Alison Murphy, Imad Nashashibi, Christopher J. Rabbat, Jiangao Song, Maria E. Wilson, Yan Zhu, Zuchun Zhao
  • MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    Publication number: 20100087468
    Abstract: The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.
    Type: Application
    Filed: October 7, 2009
    Publication date: April 8, 2010
    Applicant: Metabolex, Inc.
    Inventors: Yan ZHU, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine M. Gregoire, Vera A. Rakhmanova
  • Substituted phenylacetic acids
    Patent number: 7642358
    Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: January 5, 2010
    Assignee: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
  • 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
    Patent number: 7638541
    Abstract: Compounds, compositions, and methods relating to 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine or a pharmaceutically acceptable salt thereof are provided for the treatment of Type II diabetes and other diseases associated with poor glycemic control.
    Type: Grant
    Filed: December 26, 2007
    Date of Patent: December 29, 2009
    Assignee: Metabolex Inc.
    Inventors: Xin Chen, Peng Cheng, L. Edward Clemens, Jeffrey D. Johnson, Jingyuan Ma, Alison Murphy, Imad Nashashibi, Christoper J. Rabbat, Jiangao Song, Maria E. Wilson, Yan Zhu, Zuchun Zhao
  • Modulators of PPAR and methods of their preparation
    Patent number: 7622491
    Abstract: The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: November 24, 2009
    Assignee: Metabolex Inc.
    Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine M. Gregoire, Vera A. Rakhmanova
  • OXYMETHYLENE ARYL COMPOUNDS AND USES THEREOF
    Publication number: 20090270404
    Abstract: Use of oxymethylene aryl GPR119 agonists and DPP IV inhibitors for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control are provided.
    Type: Application
    Filed: March 30, 2009
    Publication date: October 29, 2009
    Inventors: Maria E. Wilson, Jeffrey Johnson, L. Edward Clemens, Zuchun Zhao, Xin Chen
  • N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
    Publication number: 20090137590
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
    Type: Application
    Filed: July 10, 2008
    Publication date: May 28, 2009
    Inventors: Jingyuan Ma, Christopher J. Rabbat, Jiangao Song, Xin Chen, Imad Nashashibi, Zuchun Zhao, Aaron Novack, Dong Fang Shi, Peng Cheng, Yan Zhu, Alison Murphy
  • RESOLUTION OF ALPHA-(PHENOXY)PHENYLACETIC ACID DERIVATIVES WITH NAPHTHYL-ALKYLAMINES
    Publication number: 20090093650
    Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
    Type: Application
    Filed: October 7, 2008
    Publication date: April 9, 2009
    Applicant: Metabolex, Inc.
    Inventors: Peng Cheng, Jingyuan Ma, Xin Chen, Yan Zhu, Zuchun Zhao
  • HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
    Publication number: 20090054475
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
    Type: Application
    Filed: December 26, 2007
    Publication date: February 26, 2009
    Applicant: Metabolex, Inc.
    Inventors: Xin Chen, Peng Cheng, L. Edward Clemens, Jeffrey D. Johnson, Jingyuan Ma, Alison Murphy, Imad Nashashibi, Christopher J. Rabbat, Jiangao Song, Maria E. Wilson, Yan Zhu, Zuchun Zhao
  • ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS
    Publication number: 20080287441
    Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
    Type: Application
    Filed: April 22, 2008
    Publication date: November 20, 2008
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
  • Resolution of ?-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
    Patent number: 7432394
    Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: October 7, 2008
    Assignee: Metabolex, Inc.
    Inventors: Peng Cheng, Jingyuan Ma, Xin Chen, Yan Zhu, Zuchun Zhao
  • ?-(Trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
    Patent number: 7371888
    Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: May 13, 2008
    Assignee: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
  • SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    Publication number: 20080108630
    Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: Metabolex Inc.
    Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine Gregoire, Vera Rakhmanova
  • Substituted triazoles as modulators of PPAR and methods of their preparation
    Patent number: 7323480
    Abstract: The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: January 29, 2008
    Assignee: Metabolex, Inc.
    Inventors: Yan Zhu, Jingyuan Ma, Peng Cheng, Zuchun Zhao, Francine M. Gregoire, Vera A. Rakhmanova
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 7268140
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: September 11, 2007
    Assignee: Schering AG
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Resolution of alpha-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
    Publication number: 20070073082
    Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
    Type: Application
    Filed: September 20, 2006
    Publication date: March 29, 2007
    Applicant: Metabolex, Inc.
    Inventors: Peng Cheng, Jingyuan Ma, Xin Chen, Yan Zhu, Zuchun Zhao
  • Process for the stereoselective preparation of (-)-halofenate and derivatives thereof
    Publication number: 20070072858
    Abstract: The present invention provides a compounds the formula (IV): and methods for producing an ?-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds
    Type: Application
    Filed: September 20, 2006
    Publication date: March 29, 2007
    Applicant: Metabolex, Inc.
    Inventors: Yan Zhu, Peng Cheng, Xin Chen, Jingyuan Ma, Zuchun Zhao
  • Substituted phenylacetic acids
    Publication number: 20060264630
    Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
    Type: Application
    Filed: January 4, 2006
    Publication date: November 23, 2006
    Applicant: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Liang
  • Substituted phenylacetic acids
    Patent number: 7078421
    Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: July 18, 2006
    Assignee: Metabolex, Inc.
    Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
  • Piperazine derivatives and their use as anti-inflammatory agents
    Publication number: 20060135487
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Application
    Filed: October 13, 2005
    Publication date: June 22, 2006
    Inventors: John Bauman, Brad Buckman, Ameen Ghannam, Joseph Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen May, Sean Monahan, Michael Morrissey, Howard Ng, Kenneth Shaw, Guo Wei, Wei Xu, Zuchun Zhao, Wei Zheng