Abstract: Surface structures that enable the preparation of three-dimensional microarrays of proteins or small molecules or other types of macromolecules are disclosed. The three-dimensional microarrays possess higher sensitivity for detecting protein-macromolecule and small molecule-protein interactions in a high-throughput fashion.

Abstract: Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

Abstract: The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds.

Abstract: Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: A charger and a charging system are provided. The charger includes: a rectifier, a transformer, a first diode, a capacitor, a voltage sampling feedback unit, a pulse width modulation (PWM) controller, a battery voltage feedback unit and a semiconductor switching component, where the battery voltage feedback unit is added in the charger to detect battery voltage of a terminal, and the detected battery voltage of the terminal is fed back to a voltage sampling feedback unit inside the charger, so that the voltage sampling feedback unit can adjust an output voltage of the charger in real time according to an actual battery voltage of the terminal, and therefore, the output voltage of the charger gradually rises along with an increase of the battery voltage of the terminal, thereby effectively reducing energy consumption of the charger and achieving a purpose of energy saving.

Abstract: An audio and video signal transmission interface apparatus includes a left sound channel interface, a right sound channel interface, a multimedia terminal interface, and a ground interface; where a first power supply and a first resistor are connected in series in the multimedia terminal interface; and the apparatus further includes a voltage detecting module, a determining module, a control module, and a second resistor connected in series in the multimedia terminal interface, where a resistance value of the second resistor is greater than an internal resistance value of an audio and video terminal and smaller than an internal resistance value of a microphone terminal in reverse connection; the determining module identifies different types of transmission lines by using a voltage value measured by the voltage detecting module; and the control module is configured to implement adaptation of different transmission lines.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: A voltage driving apparatus (1) for a power amplifier, a power amplifying system, a power supply device and a communication device are disclosed. The voltage driving apparatus (1) for the power amplifier includes a voltage input module (11), a voltage output module (12), a signal input module (13), and a control module (14). The voltage output module (12) is connected to the power amplifier to provide a voltage. The signal input module (13) is configured to receive a variable input electric signal. The control module (14) is electrically connected to the voltage input module (11), the voltage output module (12), and the signal input module (13) and configured to dynamically adjust the output voltage of the voltage output module (12) according to the variable input electric signal received by the signal input module (13).

Abstract: A charger and a charging system are provided. The charger includes: a rectifier, a transformer, a first diode, a capacitor, a voltage sampling feedback unit, a pulse width modulation (PWM) controller, a battery voltage feedback unit and a semiconductor switching component, where the battery voltage feedback unit is added in the charger to detect battery voltage of a terminal, and the detected battery voltage of the terminal is fed back to a voltage sampling feedback unit inside the charger, so that the voltage sampling feedback unit can adjust an output voltage of the charger in real time according to an actual battery voltage of the terminal, and therefore, the output voltage of the charger gradually rises along with an increase of the battery voltage of the terminal, thereby effectively reducing energy consumption of the charger and achieving a purpose of energy saving.

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Abstract: An audio and video signal transmission interface apparatus includes a left sound channel interface, a right sound channel interface, a multimedia terminal interface, and a ground interface; where a first power supply and a first resistor are connected in series in the multimedia terminal interface; and the apparatus further includes a voltage detecting module, a determining module, a control module, and a second resistor connected in series in the multimedia terminal interface, where a resistance value of the second resistor is greater than an internal resistance value of an audio and video terminal and smaller than an internal resistance value of a microphone terminal in reverse connection; the determining module identifies different types of transmission lines by using a voltage value measured by the voltage detecting module; and the control module is configured to implement adaptation of different transmission lines.