Abstract: The invention relates to an ophthalmic pharmaceutical composition and its preparation methods and applications, wherein the pharmaceutical composition comprises of L-Alanyl-L-Glutamine suspended or dissolved in an isoosmotic solution suitable for human eyes, and has the advantages causing minimal irritation, with high stability and a good safety profile, and which can be used for relieving dry eye disease (DED) symptoms and/or improving and/or treating DED.

Abstract: An anterior chamber perfusate for intraocular surgery and its use. The anterior chamber perfusate not only balances intraocular pressure, but also contains a certain amount of L-alanyl-L-glutamine (Ala-Gln).

Abstract: The invention relates to an ophthalmic pharmaceutical composition and its preparation methods and applications, wherein the pharmaceutical composition comprises of L-Alanyl-L-Glutamine suspended or dissolved in an isoosmotic solution suitable for human eyes, and has the advantages causing minimal irritation, with high stability and a good safety profile, and which can be used for relieving dry eye disease (DED) symptoms and/or improving and/or treating DED.

Abstract: Disclosed in the present invention is an eye drop for treating eye dryness. With a pH value of 5.0-7.0, the eye drop comprises the following components in percentage by weight: 0.05-0.1% of an active component 5-hydroxy-1-beta-D-furanosyl-1H-imidazole-5-carboxamide, an appropriate amount of a pH regulator, 0.01-3% of an isotonic agent, 0.003-0.5% of a bacteriostatic agent, 0.001-0.5% of a stabilizer, 0.01-0.5% of a tackifier, 2-5% of a solubilizer, and the balance of water. The eye drop provided by the present invention can protect the epithelial barrier function of the corneas of mice with eye dryness, increase the number of goblet cells of the corneas, and achieve relatively good anti-inflammatory and immunosuppressive effects.

Abstract: The present invention relates to a class of substituted heterocyclic derivative and preparation method thereof.

Abstract: The invention provides a compound as shown by Formula I having an enzyme activity which can inhibit endocannabinoid hydrolases NAAA and/or FAAH, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and a preparation method and a use of the compound.