Patent number: 6458816
Abstract: The present invention relates to compounds according to the structure:
Where
R is H or CH3;
R2 is phosphate which can be free acid or salt;
R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C1-C3 alkyl group;
R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; and
R5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.
Type:
Grant
Filed:
October 15, 2001
Date of Patent:
October 1, 2002
Assignee:
Vion Pharmaceuticals, Inc.
Inventors:
Terrence W. Doyle, Srinivasa Karra, Zujin Li, Xu Lin, John Mao, Qi Qiao, Yang Xu
