Patents by Inventor Zulan Pi

Zulan Pi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS
    Publication number: 20230250063
    Abstract: The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 10, 2023
    Inventors: James A. Johnson, Zulan Pi, Nicholas R. Wurtz, Joanne M. Smallheer, Meriah Neissel Valente, Ellen K. Kick, Charles G. Clark, Pravin Sudhaka Shirude, Balaji Kumar Seshadri, Amit Kumar Chattopadhyay
  • PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS
    Publication number: 20220002281
    Abstract: The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases.
    Type: Application
    Filed: November 25, 2019
    Publication date: January 6, 2022
    Inventors: Nicholas R. WURTZ, James A. JOHNSON, Zulan PI, Andrew Quoc VIET
  • Heteroarylhydroxypyrimidinones as agonists of the APJ receptor
    Patent number: 10669261
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 2, 2020
    Assignee: Bristl-Myers Squibb Company
    Inventors: Michael C. Myers, R. Michael Lawrence, Donna M. Bilder, Wei Meng, Zulan Pi, Robert Paul Brigance, Heather Finlay
  • 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as APJ agonists
    Patent number: 10590113
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 17, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zulan Pi, Donna M. Bilder, Robert Paul Brigance, Heather Finlay, Wen Jiang, James A. Johnson, R. Michael Lawrence, Wei Meng, Michael C. Myers, Monique Phillips, George O. Tora, Xiaojun Zhang
  • Sulfone amide linked benzothiazole inhibitors of endothelial lipase
    Patent number: 10173991
    Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used medicaments.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: January 8, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: James A. Johnson, Zulan Pi, Jennifer X. Qiao, Soong-Hoon Kim, Tammy C. Wang, Ji Jiang, Heather Finlay, John Lloyd
  • 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS
    Publication number: 20190002441
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Inventors: Zulan Pi, Donna M. Bilder, Robert Paul Brigance, Heather Finlay, Wen Jiang, James A. Johnson, R. Michael Lawrence, Wei Meng, Michael C. Myers, Monique Phillips, George O. Tora, Xiaojun Zhang
  • HETEROARYLHYDROXYPYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR
    Publication number: 20180362508
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
    Type: Application
    Filed: December 15, 2016
    Publication date: December 20, 2018
    Inventors: Michael C. Myers, R. Michael Lawrence, Donna M. Bilder, Wei Meng, Zulan Pi, Robert Paul Brigance, Heather Finlay
  • 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as APJ agonists
    Patent number: 10106528
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: October 23, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zulan Pi, Donna M. Bilder, Robert Paul Brigance, Heather Finlay, Wen Jiang, James A. Johnson, R. Michael Lawrence, Wei Meng, Michael C. Myers, Monique Phillips, George O. Tora, Xiaojun Zhang
  • 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS
    Publication number: 20170275272
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Application
    Filed: March 24, 2017
    Publication date: September 28, 2017
    Inventors: Zulan Pi, Donna M. Bilder, Robert Paul Brigance, Heather Finlay, Wen Jiang, James A. Johnson, R. Michael Lawrence, Wei Meng, Michael C. Myers, Monique Phillips, George O. Tora, Xiaojun Zhang
  • 7-hydroxy-indolinyl antagonists of P2Yreceptor
    Patent number: 9540323
    Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: January 10, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alexandre L'Heureux, Sheldon Hiebert, Carol Hu, Patrick Y. S. Lam, John Lloyd, Zulan Pi, Jennifer X. Qiao, Carl Thibeault, George O. Tora, Wu Yang, Yufeng Wang, Tammy C. Wang, Michael S. Bowsher, Ruel Rejean
  • Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
    Patent number: 9493412
    Abstract: The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: November 15, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jennifer X. Qiao, Heather Finlay, Ji Jiang, John Lloyd, Carol Hui Hu, Zulan Pi, George O. Tora, James Neels, Jon J. Hangeland, Todd J. Friends
  • SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE
    Publication number: 20160326125
    Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used medicaments.
    Type: Application
    Filed: January 5, 2015
    Publication date: November 10, 2016
    Inventors: James A. Johnson, Zulan Pi, Jennifer X. Qiao, Soong-Hoon Kim, Tammy C. Wang, Ji Jiang, Heather Finlay, John Lloyd
  • Ketone linked benzothiazole inhibitors of endothelial lipase
    Patent number: 9169240
    Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: October 27, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: George O. Tora, Heather Finlay, Carol Hui Hu, Ji Jiang, James A. Johnson, Soong-Hoon Kim, John Lloyd, Brandon Parkhurst, Zulan Pi, Jennifer X. Qiao, Tammy C. Wang
  • Amide or urea containing benzothiazole inhibitors of endothelial lipase
    Patent number: 9139578
    Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: September 22, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zulan Pi, Jennifer X. Qiao, George O. Tora, Tammy C. Wang
  • 7-HYDROXY-INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR
    Publication number: 20150259286
    Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.
    Type: Application
    Filed: July 30, 2013
    Publication date: September 17, 2015
    Inventors: Alexandre L'Heureux, Sheldon Hiebert, Carol Hu, Patrick Y.S. Lam, John Lloyd, Zulan Pi, Jennifer X. Qiao, Carl Thibeault, George O. Tora, Wu Yang, Yufeng Wang, Tammy C. Wang, Michael S. Bowsher, Ruel Rejean
  • Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
    Patent number: 9120794
    Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 1, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lynn Abell, Leonard Adam, Cullen L. Cavallaro, Heather Finlay, Todd J. Friends, Jon J. Hangeland, Ji Jang, R. Michael Lawrence, John Lloyd, Zulan Pi, George O. Tora, Jennifer X. Qiao, Carol Hui Hu, Tammy C. Wang
  • KETONE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE
    Publication number: 20150239879
    Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
    Type: Application
    Filed: September 5, 2013
    Publication date: August 27, 2015
    Inventors: George O. Tora, Heather Finlay, Carol Hui Hu, Ji Jiang, James A. Johnson, Soong-Hoon Kim, John Lloyd, Brandon Parkhurst, Zulan Pi, Jennifer X. Qiao, Tammy C. Wang
  • AMIDE OR UREA CONTAINING BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE
    Publication number: 20150158856
    Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Application
    Filed: July 3, 2013
    Publication date: June 11, 2015
    Inventors: Zulan Pi, Jennifer X. Qiao, George O. Tora, Tammy C. Wang
  • PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS
    Publication number: 20150105378
    Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 16, 2015
    Inventors: Lynn Abell, Leonard Adam, Cullen L. Cavallaro, Heather Finlay, Todd J. Friends, Jon J. Hangeland, Ji Jiang, R. Michael Lawrence, John Lloyd, Zulan Pi, George O. Tora, Jennifer X. Qiao, Carol Hui Hu, Tammy C. Wang
  • Pyridinedione carboxamide inhibitors of endothelial lipase
    Patent number: 8993557
    Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: March 31, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Lloyd, Jennifer X. Qiao, Heather Finlay, James Neels, Zulan Pi, Carol Hui Hu, Tammy C. Wang