Patents by Inventor Zulema R. GARCIA

Zulema R. GARCIA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LENTIVIRAL VECTOR FOR STEM CELL GENE THERAPY OF SICKLE CELL DISEASE
    Publication number: 20170157270
    Abstract: In various embodiments a recombinant lentiviral vector is provided comprising an expression cassette comprising a nucleic acid construct comprising an anti-sickling human beta globin gene encoding an anti-sickling-beta globin polypeptide comprising the mutations Gly16Asp, Glu22Ala and Thr87Gln, where the lentiviral vector is a TAT-independent and self-inactivating (SIN). In certain embodiments the vector additionally contains one or more insulator elements. The vectors are useful in gene therapy for the treatment of sickle cell disease.
    Type: Application
    Filed: November 9, 2016
    Publication date: June 8, 2017
    Inventors: Donald B. Kohn, Fabrizia Urbinati, Zulema R. Garcia, Roger P. Hollis, Sabine Geiger-Schredelseker, Aaron R. Cooper, Shantha Senadheera
  • LENTIVIRAL VECTOR FOR STEM CELL GENE THERAPY OF SICKLE CELL DISEASE
    Publication number: 20150224209
    Abstract: In various embodiments a recombinant lentiviral vector is provided comprising an expression cassette comprising a nucleic acid construct comprising an anti-sickling human beta globin gene encoding an anti-sickling-beta globin polypeptide comprising the mutations Gly16Asp, Glu22Ala and Thr87Gln, where the lentiviral vector is a TAT-independent and self-inactivating (SIN). In certain embodiments the vector additionally contains one or more insulator elements. The vectors are useful in gene therapy for the treatment of sickle cell disease.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 13, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Donald B. KOHN, Fabrizia URBINATI, Zulema R. GARCIA, Roger HOLLIS, Sabine GEIGER-SCHREDELSEKER, Aaron COOPER, Shantha SENADHEERA