Patents by Inventor Zuoguang Zhang

Zuoguang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230095701
    Abstract: Use of albiflorin or a pharmaceutically acceptable salt thereof or an extract or a pharmaceutical composition containing albiflorin in the preparation of a medicament for preventing or treating coronavirus pneumonia, especially novel coronavirus pneumonia, or use thereof in the preparation of a medicament for treating prolonged symptoms of novel coronavirus pneumonia, performing rehabilitation conditioning after recovery of novel coronavirus pneumonia, or alleviating a possible sequela of novel coronavirus pneumonia, the sequela being depression, anxiety, sleep disorder, pain, palpitation, asthma, intestinal function disorder, or chronic fatigue syndrome. Albiflorin has the effects of anti-coronavirus, anti-inflammatory, inflammatory storm inhibition, human microecological balance regulation, etc.
    Type: Application
    Filed: September 25, 2020
    Publication date: March 30, 2023
    Inventor: Zuoguang Zhang
  • Patent number: 11020415
    Abstract: Use of albiflorin or a pharmaceutically acceptable salt thereof in the preparation of a product for regulating and improving the balance of human intestinal flora. Albiflorin or a pharmaceutically acceptable salt thereof, as a regulator for improving the function of intestinal flora system, can be used in the preparation of a medicament, a health care product, a food, a food additive, or a nutritional supplement that ameliorates and treats a sub-health status and/or a disease caused by intestinal flora disturbance; the sub-health status is selected from intestinal system dysfunction and/or affective disorder; and the disease is selected from one or more of irritable bowel syndrome, depression, anxiety, colitis, and colon cancer.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: June 1, 2021
    Inventor: Zuoguang Zhang
  • Publication number: 20200046748
    Abstract: Use of albiflorin or a pharmaceutically acceptable salt thereof in the preparation of a product for regulating and improving the balance of human intestinal flora. Albiflorin or a pharmaceutically acceptable salt thereof, as a regulator for improving the function of intestinal flora system, can be used in the preparation of a medicament, a health care product, a food, a food additive, or a nutritional supplement that ameliorates and treats a sub-health status and/or a disease caused by intestinal flora disturbance; the sub-health status is selected from intestinal system dysfunction and/or affective disorder; and the disease is selected from one or more of irritable bowel syndrome, depression, anxiety, colitis, and colon cancer.
    Type: Application
    Filed: August 4, 2017
    Publication date: February 13, 2020
    Inventor: Zuoguang Zhang
  • Publication number: 20190336519
    Abstract: Use of albiflorin or a pharmaceutically acceptable salt thereof as an IDO inhibitor. Albiflorin or a pharmaceutically acceptable salt thereof as an IDO inhibitor can be used for the preparation of a drug, a food, a health care product, a food additive or a nutritional supplement for the prevention or treatment of diseases having a pathological feature involving tryptophan metabolic pathway mediated by overactivation of IDO, and these diseases are selected from one or more of cancer, depression, Alzheimer's disease, and Parkinson's disease.
    Type: Application
    Filed: August 4, 2017
    Publication date: November 7, 2019
    Inventor: Zuoguang Zhang
  • Patent number: 10350230
    Abstract: Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bowel syndrome with albiflorin or a pharmaceutically acceptable salt has significant effects and few side effects. This is a preparation derived from a natural plant for the safe, effective and multi-targeted prevention, remission and/or treatment of irritable bowel syndrome.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: July 16, 2019
    Inventor: Zuoguang Zhang
  • Publication number: 20180028550
    Abstract: Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bowel syndrome with albiflorin or a pharmaceutically acceptable salt has significant effects and few side effects. This is a preparation derived from a natural plant for the safe, effective and multi-targeted prevention, remission and/or treatment of irritable bowel syndrome.
    Type: Application
    Filed: April 27, 2015
    Publication date: February 1, 2018
    Inventor: Zuoguang Zhang
  • Publication number: 20170274032
    Abstract: Pharmaceutical compositions or functional foods for treating anxiety comprising ginseng saponin (Rg1+Rb1), glycyrrhizic acid and jujuba cAMP. Experiments demonstrate that as compared with the preferred drug for treating diazepam in the art, the present invention has significant anxielytic efficacy.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Applicants: Beijing Wonner Biotech. Ltd. Co.
    Inventor: Zuoguang Zhang
  • Patent number: 9572827
    Abstract: A pharmaceutical composition for treating depression and method for preparation thereof is provided. The pharmaceutical composition includes Radix Ginseng, Radix Glycyrrhizae, and/or their aqueous or alcoholic extract. Fructus Jujubae or their aqueous or alcoholic extract can also be included in the pharmaceutical composition.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: February 21, 2017
    Assignees: Beijing Wonner Biotech. Ltd. Co.
    Inventor: Zuoguang Zhang
  • Patent number: 9555055
    Abstract: Disclosed is a use of albiflorin or a metabolite thereof in preparation of antianxiety and sleep disorder improving drugs or health-care food. Tests prove that albiflorin has significant antianxiety effects and sleep disorder improving effects achieved by prolonging SWS and low the toxic side effects, thus being a safety monomer compound capable of effectively treating anxiety and sleep disorder.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: January 31, 2017
    Inventor: Zuoguang Zhang
  • Patent number: 9453041
    Abstract: The present invention discloses a method for preparing high purity paeoniflorin and albiflorin simultaneously comprising: extraction the raw material Paeonia Lactiflora by percolation or heating reflux to obtain the Paeonia Lactiflora extract solution, then purification by macroporous absorption resin, alumina column and silica gel column in turn to obtain high purity paeoniflorin and albiflorin. The preparation method of the invention can provide high purity paeoniflorin and albiflorin with low price and energy-consumption by the identical procedure. The process is simple. The purification efficacy is high and the purification time is short.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: September 27, 2016
    Inventor: Zuoguang Zhang
  • Patent number: 9023817
    Abstract: A pharmaceutical composition containing albiflorin and use thereof in manufacturing medicaments for preventing and treating depression are provided by the present invention.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: May 5, 2015
    Inventor: Zuoguang Zhang
  • Patent number: 8889650
    Abstract: An antimelancholic pharmaceutical composition or health products prepared with jujuba cAMP materials and a preparative method are provided in the present invention. The present pharmaceutical composition includes jujuba cAMP as a solo effective ingredient for treating the depression. The present method for preparing the jujuba cAMP includes chromatographing a jujuba extract with a macroporous resin bound with an aldehyde group.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: November 18, 2014
    Assignees: Beijing Wonner Biotech, Ltd. Co.
    Inventor: Zuoguang Zhang
  • Publication number: 20140065125
    Abstract: A pharmaceutical composition for treating depression and method for preparation thereof is provided. The pharmaceutical composition includes Radix Ginseng, Radix Glycyrrhizae, and/or their aqueous or alcoholic extract. Fructus Jujubae or their aqueous or alcoholic extract can also be included in the pharmaceutical composition.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicants: Beijing Wonner Biothech, Ltd. Co.
    Inventor: Zuoguang Zhang
  • Publication number: 20140013826
    Abstract: An apparatus for testing the gas permeability on the inward facing direction of a pre-impregnated resin matrix composite material layer includes a mold, a loading apparatus, a temperature control apparatus, a vacuuming apparatus, and a flow detecting element. A test specimen is laid flat inside the mold between airtight sealing elements that leave exposed two ends of the test specimen on the inward facing direction of the layer. An air inlet and an air outlet respectively are arranged on the mold and correspond to the two exposed ends of the test specimen. The inlet is connected to the flow detecting element, and the outlet is connected to the vacuuming apparatus. Air is forced to move in a vacuumed cavity along the inward facing direction of the layer. Testing of air permeability of pre-impregnated material in solidification technique is allowed via adjustments of pressure and temperature.
    Type: Application
    Filed: December 31, 2011
    Publication date: January 16, 2014
    Applicants: SHANGHAI AIRCRAFT MANUFACTURING CO LTD, COMMERCIAL AIRCRAFT CORPORATION OF CHINA LTD
    Inventors: Weiping Liu, Dongmei Zhang, Xiaoxing Ma, Jun Liu, Zhiyuan Li, Xinjing Wang, Yizhu Zheng, Xu Wang, Jiazhi Su, Chaobo Xin, Yizhuo Gu, Min Li, Yanxia Li, Zuoguang Zhang
  • Publication number: 20140013825
    Abstract: An apparatus for testing the air permeability in the thickness direction of a resin matrix composite material layer includes a mold having a cavity and a covering plate, a loading apparatus, a temperature controlling apparatus, a vacuuming apparatus, and a flow detecting element. An air inlet is connected to the flow detecting element, and an air outlet is connected to the vacuuming apparatus. The covering plate has a through-hole with upper and lower ventilation pieces. The loading apparatus addresses the upper ventilation piece. A test specimen is laid flat between the ventilation pieces. Employment of the present invention allows for accurate testing of air permeability of pre-impregnated material in the thickness direction of the resin matrix composite material layer under different pressure and temperature conditions.
    Type: Application
    Filed: December 31, 2011
    Publication date: January 16, 2014
    Applicants: SHANGHAI AIRCRAFT MANUFACTURING CO., LTD, COMMERCIAL AIRCRAFT CORPORATION OF CHINA, LTD.
    Inventors: Weiping Liu, Dongmei Zhang, Yizhu Zheng, Xu Wang, Jiazhi Su, Xiaoxing Ma, Jun Liu, Zhiyuan Li, Xinjing Wang, Min Li, Yizhuo Gu, Chaobo Xin, Yanxia Li, Zuoguang Zhang
  • Publication number: 20130316966
    Abstract: Disclosed is a use of albiflorin or a metabolite thereof in preparation of antianxiety and sleep disorder improving drugs or health-care food. Tests prove that albiflorin has significant antianxiety effects and sleep disorder improving effects achieved by prolonging SWS and low the toxic side effects, thus being a safety monomer compound capable of effectively treating anxiety and sleep disorder.
    Type: Application
    Filed: November 9, 2011
    Publication date: November 28, 2013
    Inventor: Zuoguang Zhang
  • Publication number: 20130231469
    Abstract: The present invention discloses a method for preparing high purity paeoniflorin and albiflorin simultaneously comprising: extraction the raw material Paeonia Lactiflora by percolation or heating reflux to obtain the Paeonia Lactiflora extract solution, then purification by macroporous absorption resin, alumina column and silica gel column in turn to obtain high purity paeoniflorin and albiflorin. The preparation method of the invention can provide high purity paeoniflorin and albiflorin with low price and energy-consumption by the identical procedure. The process is simple. The purification efficacy is high and the purification time is short.
    Type: Application
    Filed: November 10, 2010
    Publication date: September 5, 2013
    Inventor: Zuoguang Zhang
  • Publication number: 20130040903
    Abstract: Pharmaceutical compositions or functional foods for treating depression and anxiety comprising ginseng saponin (Rgl+Rbl), glycyrrhizic acid and jujuba cAMP. Experiments demonstrate that as compared with the preferred drug for treating depression and anxiety paroxetine and diazepam in the art, the present invention has significant anti-depression and anxielytic efficacy.
    Type: Application
    Filed: October 18, 2012
    Publication date: February 14, 2013
    Inventors: Yu-Fen Chi, Zuoguang Zhang
  • Publication number: 20120270820
    Abstract: A pharmaceutical composition containing albiflorin and use thereof in manufacturing medicaments for preventing and treating depression are provided by the present invention.
    Type: Application
    Filed: August 24, 2010
    Publication date: October 25, 2012
    Inventor: Zuoguang Zhang
  • Publication number: 20100311674
    Abstract: Oral pharmaceutical compositions or functional foods with a mechanism of multi-target receptor retroaction for treating depression comprising ginseng saponin (Rg1+Rb1), glycyrrhizic acid and jujuba cAMP. Experiments demonstrate that as compared with the preferred drug for treating depression Paroxetine in the art, the present invention has significant anti-depression efficacy.
    Type: Application
    Filed: November 30, 2007
    Publication date: December 9, 2010
    Applicants: Yu-Fen Chi, Zuoguang Zhang
    Inventor: Zuoguang Zhang