Patents by Inventor Zuomei Li

Zuomei Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination Therapy
    Publication number: 20090124631
    Abstract: The invention relates to the treatment of mammalian diseases manifested by abnormal cell growth and/or abnormal cell proliferation. More particularly, the invention relates to the use of combination therapies to control abnormal cell growth and/or abnormal cell proliferation. In particular, the invention relates to the use of isotype-selective inhibitors of histone deacetylases 1, 2 and/or 3 (HDACs 1-3), as well as isotype-selective inhibitors of HDAC1 and/or HDAC2, to potentiate therapeutic activity of microtubule-stabilization agents.
    Type: Application
    Filed: September 12, 2008
    Publication date: May 14, 2009
    Inventors: Zuomei Li, Koji Murakami
  • Assay for efficacy of histone deacetylase inhibitors
    Publication number: 20070292351
    Abstract: The invention provides methods for assessing the efficacy of histone deacetylase inhibitors using biomarkers which can be used in human clinical trials and which are more quantitative, easy to be used and more relevant to clinical outcome for PD monitoring than existing assays. The method according to the invention utilizes biomarkers from blood cells from patients treated with HDAC inhibitors which are easy to assay.
    Type: Application
    Filed: May 25, 2007
    Publication date: December 20, 2007
    Inventors: Zuomei Li, Christiane Maroun, Jianhong Liu, Jeffrey Besterman, Claire Bonfils
  • Inhibition of histone deacetylase
    Publication number: 20070105808
    Abstract: The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.
    Type: Application
    Filed: November 9, 2006
    Publication date: May 10, 2007
    Applicant: MethylGene, Inc.
    Inventors: A. MacLeod, Zuomei Li, Jeffrey Besterman
  • Histone deacetylase whole cell enzyme assay
    Publication number: 20060063210
    Abstract: The invention relates to enzymatic assays for protein deacetylases. More particularly, the invention relates to such assays utilizing whole cells. The invention provides assays which allow assessment of the level of a protein deacetylase activity in whole cells taken directly from the body of the mammal.
    Type: Application
    Filed: September 21, 2005
    Publication date: March 23, 2006
    Inventors: Zuomei Li, Jeffrey Besterman, Claire Bonfils
  • Modulation of gene expression by combination therapy
    Patent number: 6953783
    Abstract: The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same. In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: October 11, 2005
    Assignee: MethylGene, Inc.
    Inventors: Jeffrey M. Besterman, Robert A. Macleod, William M. Siders, Zuomei Li
  • Inhibition of specific histone deacetylase isoforms
    Publication number: 20040266718
    Abstract: This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 30, 2004
    Inventors: Zuomei Li, Claire Bonfils, Jeffrey Besterman
  • Methods for specifically inhibiting histone deacetylase-7 and 8
    Publication number: 20040072770
    Abstract: This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-7 and HDAC-8 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 15, 2004
    Inventors: Jeffrey M. Besterman, Zuomei Li, Daniel Delorme, Claire Bonfils
  • Methods for inhibiting histone deacetylase-4
    Publication number: 20030152557
    Abstract: This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-4 and HDAC-1 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
    Type: Application
    Filed: January 14, 2002
    Publication date: August 14, 2003
    Inventors: Jeffrey M. Besterman, Claire Bonfils, Zuomei Li, Soon Hyung Woo, Arkadii Vaisburg, Daniel Delorme, Marielle Fournel, Rico Lavoie
  • Methods for specifically inhibiting histone deacetylase-4
    Publication number: 20030148970
    Abstract: This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-4 and HDAC-1 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
    Type: Application
    Filed: January 14, 2002
    Publication date: August 7, 2003
    Inventors: Jeffrey M. Besterman, Claire Bonfils, Zuomei Li, Soon Hyung Woo, Arkadii Vaisburg, Daniel Delorme, Marielle Fournel, Rico Lavoie
  • Modulation of gene expression by combination therapy
    Publication number: 20030096777
    Abstract: The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same.
    Type: Application
    Filed: May 14, 2002
    Publication date: May 22, 2003
    Inventors: Jeffrey M. Besterman, Robert A. MacLeod, William M. Siders, Zuomei Li
  • Inhibition of histone deactylase
    Publication number: 20030078216
    Abstract: The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.
    Type: Application
    Filed: May 3, 2000
    Publication date: April 24, 2003
    Inventors: A. Robert MacLeod, Zuomei Li, Jeffrey M. Besterman
  • Antisense oligonucleotide inhibition of specific histone deacetylase isoforms
    Publication number: 20020137162
    Abstract: This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.
    Type: Application
    Filed: March 26, 2001
    Publication date: September 26, 2002
    Inventors: Zuomei Li, Claire Bonfils, Jeffrey M. Besterman
  • Antisense oligonucleotide inhibition of specific histone deacetylase isoforms
    Publication number: 20020061860
    Abstract: This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.
    Type: Application
    Filed: August 6, 2001
    Publication date: May 23, 2002
    Inventors: Zuomei Li, Claire Bonfils, Jeffrey Besterman