Patents by Inventor Zuoren YU

Zuoren YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MicroRNA inhibitor
    Patent number: 11306310
    Abstract: A microRNA (miRNA) inhibitor, being able to form a stable DNA-RNA double-stranded structure with a miRNA. The double-stranded structure comprises: (i) a miRNA unit sequence, and (ii) an RNA zipper unit sequence. The 5?-end of the RNA zipper unit sequence is connected to the 5?-end of the miRNA unit sequence. The 3?-end of the RNA zipper unit sequence is connected to the 3?-end of the miRNA unit sequence. The RNA zipper can connect the head of the miRNA molecule to the tail of the miRNA molecule to form a stable long-chain structure. The RNA zipper unit sequence contains 1-3 nucleotides not connected to the miRNA unit sequence. The DNA-RNA double-stranded structure can be used to inhibit biological activities of a miRNA unit, does not have biological toxicity, and has the advantages of high affinity, high specificity and high stability.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: April 19, 2022
    Assignee: SHANGHAI EAST HOSPITAL
    Inventors: Zuoren Yu, Zhongmin Liu, Qian Zhao
  • MICRORNA INHIBITOR
    Publication number: 20200071697
    Abstract: A microRNA (miRNA) inhibitor, being able to form a stable DNA-RNA double-stranded structure with a miRNA. The double-stranded structure comprises: (i) a miRNA unit sequence, and (ii) an RNA zipper unit sequence. The 5?-end of the RNA zipper unit sequence is connected to the 5?-end of the miRNA unit sequence. The 3?-end of the RNA zipper unit sequence is connected to the 3?-end of the miRNA unit sequence. The RNA zipper can connect the head of the miRNA molecule to the tail of the miRNA molecule to form a stable long-chain structure. The RNA zipper unit sequence contains 1-3 nucleotides not connected to the miRNA unit sequence. The DNA-RNA double-stranded structure can be used to inhibit biological activities of a miRNA unit, does not have biological toxicity, and has the advantages of high affinity, high specificity and high stability.
    Type: Application
    Filed: July 19, 2017
    Publication date: March 5, 2020
    Applicant: Shanghai East Hospital
    Inventors: Zuoren YU, Zhongmin LIU, Qian ZHAO