Patents by Inventor Zuoshang Xu

Zuoshang Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC PROMOTERS FOR GENE THERAPY AND PROTEIN EXPRESSION
    Publication number: 20240043872
    Abstract: The invention provides synthetic promoters and methods of using the same.
    Type: Application
    Filed: March 11, 2022
    Publication date: February 8, 2024
    Inventors: Yang WANG, Mark S. KLEMPNER, Monir EJEMEL, Qi LI, Zuoshang XU
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20230332179
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: November 8, 2022
    Publication date: October 19, 2023
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS targeting AAV vectors and methods of use thereof
    Patent number: 10731178
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: August 4, 2020
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20190276848
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 12, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20190276849
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 12, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • Detection Of Gene Loci With CRISPR Arrayed Repeats And/Or Polychromatic Single Guide Ribonucleic Acids
    Publication number: 20190249230
    Abstract: A C9orf72 DNA repeat expansion can be detected using a CRISPR Arrayed Repeat Detection System (CARDS). Based upon the compositions and methods supporting this platform primary cell cultures and/or blood cell smears can be tested under conventional clinical diagnostic laboratory conditions to diagnose genetically-based diseases having DNA repeat expansions, including but not limited to ALS. dCas9 constructs are also contemplated as having fluorescent proteins bound to any or all stem loop sequences, wherein detection of a plurality of dCas9 constructs having different colored fluorescent proteins can simultaneously detect at least six (6) different gene target loci.
    Type: Application
    Filed: September 1, 2016
    Publication date: August 15, 2019
    Inventors: Thoru PEDERSON, Hanhui MA, Li-Chun TU, Ardalan NASERI, Zuoshang XU, Maximilaan HUISMAN, Chunxing YANG, Shaojie ZHANG
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20190194688
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: December 28, 2018
    Publication date: June 27, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20190194689
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: December 28, 2018
    Publication date: June 27, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20180148738
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: June 5, 2017
    Publication date: May 31, 2018
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20170349911
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: June 5, 2017
    Publication date: December 7, 2017
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS targeting AAV vectors and methods of use thereof
    Patent number: 9701984
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: July 11, 2017
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • Anti-SOD1 antibodies and uses thereof
    Patent number: 9663586
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: May 30, 2017
    Assignee: University of Massachusetts
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Zuoshang Xu
  • ANTI-SOD1 ANTIBODIES AND USES THEREOF
    Publication number: 20150322167
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Application
    Filed: July 28, 2015
    Publication date: November 12, 2015
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna AMBROSINO, Gregory BABCOCK, Teresa BROERING, Zuoshang XU
  • Anti-SOD1 antibodies and uses thereof
    Patent number: 9109037
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: August 18, 2015
    Assignee: University of Massachusetts
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Zuoshang Xu
  • CNS targeting AAV vectors and methods of use thereof
    Patent number: 9102949
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: August 11, 2015
    Assignee: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20140335054
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 13, 2014
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • ANTI-SOD1 ANTIBODIES AND USES THEREOF
    Publication number: 20140044722
    Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 13, 2014
    Applicant: University of Massachusetts
    Inventors: Donna Ambrosino, Gregory Babcock, Teresa Broering, Zuoshang Xu
  • CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF
    Publication number: 20130195801
    Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
    Type: Application
    Filed: April 22, 2011
    Publication date: August 1, 2013
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Hongwei Zhang, Hongyan Wang, Zuoshang Xu
  • Allele-specific RNA interference
    Patent number: 8309533
    Abstract: Human diseases caused by dominant, gain-of-function mutations develop in heterozygotes bearing one mutant and one wild-type copy of a gene. Because the wild-type gene often performs important functions, whereas the mutant gene is toxic, any therapeutic strategy must selectively inhibit the mutant while retaining wild-type gene expression. The present invention includes methods of specifically inhibiting the expression of a mutant allele, while preserving the expression of a co-expressed wild-type allele using RNAi, a therapeutic strategy for treating genetic disorders associated with dominant, gain-of-function gene mutations. The invention also includes small interfering RNAs (siRNAs) and small hairpin RNAs (shRNAs) that selectively suppress mutant, but not wild-type, expression of copper zinc superoxide dismutase (SOD1), which causes inherited amyotrophic lateral sclerosis (ALS). The present invention further provides asymmetric siRNAs and shRNAs with enhanced efficacy and specificity and mediating RNAi.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: November 13, 2012
    Assignee: University of Massachusetts
    Inventor: Zuoshang Xu
  • Methods and compositions for treating gain-of-function disorders using RNA interference
    Patent number: 8008271
    Abstract: The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the copper zinc superoxide dismutase (SOD1), which causes inherited amyotrophic lateral sclerosis (ALS), with RNAi agent. The invention further provides RNAi resistant replacement genes containing mismatches with their respective RNAi agents. The invention also provides for vectors that express RNAi agent and RNAi resistant replacement gene of the present invention.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: August 30, 2011
    Assignee: University of Massachusetts
    Inventors: Zuoshang Xu, Xugang Xia