Abstract: A method for predicting that an individual has antiphospholipid syndrome or an increased likelihood of having antiphospholipid syndrome, includes: a) providing a test sample from an individual; b) combining the test sample with phospholipids; c) directing a light beam at the test sample and monitoring light scattering or transmittance over time so as to provide a time-dependent measurement profile; d) determining if a value or a slope at or over a particular time in the time-dependent measurement profile is beyond a corresponding predetermined value or slope threshold; and if the value or slope in the time-dependent measurement profile is beyond the predetermined threshold, then determining that the individual has antiphospholipid syndrome or an increased risk of antiphospholipid syndrome. The phospholipids can be provided as part of a coagulation reagent, or as part of a reagent where coagulation is not activated.