Abstract: A biomedical system for targeted delivery of a therapeutic agent to a tissue region of a subject is provided. The biomedical system comprises: (a) a biomedical device including: (i) a device body designed and configured for implantation within the tissue region of the subject; and (ii) a first member of a binding pair attached to a surface of said device body; and (b) a delivery vehicle including: (i) a carrier particle designed for carrying the therapeutic agent; (ii) a second member of said binding pair attached to said carrier particle, said second member of said binding pair being capable of specifically interacting with said first member of said binding pair thereby enabling targeting of said delivery vehicle to said biomedical device when implanted within said tissue region.