Abstract: The present invention relates to a lipidoid of general formula I, wherein X is selected from —C(?O)NH—, —C(?O)O—, —C(?S)O—, —C(?O)S—, —C(?S)S—, —C(?O)NHNH—, —CH2—, —O—, —OC(?O)—, —S—, —SC(?O)—, —NH—, —NHNH—, —NHC(?O)—, —NHNHC(?O)—, —C?C—, —CH?CH—, a five-membered heterocycle containing at least 2 nitrogen atoms, —CH2C(?O)NH—, —CH2C(?S)O—, —CH2C(?S)S—, —CH2C(?O)NHNH—, —N?CH—, —CH?N—, —NH—N?CH—, and —CH?N—NH—; Y is alkylene C2-C10 chain; R1 is selected from alkyl C1-C46, alkenyl C2-C46, alkynyl C2-C46; Z is selected from H, —OH, —CH3, —CH2OH, —NH2, —C(?O)NH2, —CONH(CH2)2OH, —CON[(CH2)2OH]2, —CONHCH(CH2OH)2, —CONHCH2CH(—OH)CH2OH, —CONH(CH2)2C(?O)NH2, —CON[CH2C(?O)NH2]2, —CONH(CH2)2NHC(?O)NH2, —CONH(CH2)3—N+(CH3)2—(CH2)2—SO3—, —CONH(CH2)3—N+(CH3)2—(CH2)2—COO?, —COO(CH2)2—O—P(?O)(O—)—O(CH2)2—N+(CH3)3, —N+(CH3)2—(CH2)3—SO3—, —N+(CH3)2—(CH2)2—COO?, formula (II), and formula (III), wherein R2 is independently selected from hydrogen and —CH3; E is independently selected from O and S atoms; n is an integer within the r