Patents by Inventor Zuze Wu

Zuze Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10000738
    Abstract: Provided in the present invention are odontogenic stem cells and a use of genetically modified odontogenic stem cells for treating periodontal disease, repairing defects in periodontal bone tissues or soft tissues and/or promoting the regeneration of periodontal tissues, or in products for treating acute and chronic bone tissue injuries (e.g. bone fracture) or bone tissue defects. Also provided in the present invention is a composition comprising odontogenic stem cells and/or genetically modified odontogenic stem cells, wherein an exogenous hepatocyte growth factor gene is introduced into odontogenic stem cells through an adenovirus or adeno-associated virus vector to obtain the genetically modified odontogenic stem cells.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: June 19, 2018
    Assignees: Beijing Stomatology Hospital, Capital Medical University, Beijing SH Bio-Tech Corporation
    Inventors: Songling Wang, Zuze Wu, Yu Cao, Hua Wang, Yi Liu, Jinsong Wang, Jingchao Hu, Jianjin Bi, Yilin Xie, Wenqiang An
  • Publication number: 20160348076
    Abstract: Provided in the present invention are odontogenic stem cells and a use of genetically modified odontogenic stem cells for treating periodontal disease, repairing defects in periodontal bone tissues or soft tissues and/or promoting the regeneration of periodontal tissues, or in products for treating acute and chronic bone tissue injuries (e.g. bone fracture) or bone tissue defects. Also provided in the present invention is a composition comprising odontogenic stem cells and/or genetically modified odontogenic stem cells, wherein an exogenous hepatocyte growth factor gene is introduced into odontogenic stem cells through an adenovirus or adeno-associated virus vector to obtain the genetically modified odontogenic stem cells.
    Type: Application
    Filed: January 27, 2015
    Publication date: December 1, 2016
    Applicants: Beijing Stomatology Hospital, Capital Medical University, Beijing SH Bio-Tech Corporation
    Inventors: Songling WANG, Zuze WU, Yu CAO, Hua WANG, Yi LIU, Jinsong WANG, Jingchao HU, Jianjin BI, Yilin XIE, Wenqiang AN
  • Patent number: 8361795
    Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: January 29, 2013
    Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLA
    Inventors: Zuze Wu, Bingxing Shi, Chunping Cui, Shaojun Du, Danli Wu
  • Patent number: 8212003
    Abstract: This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: July 3, 2012
    Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLA
    Inventors: Bingxing Shi, Zuze Wu, Aiping Yu, Chunna Dong
  • Patent number: 8101379
    Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: January 24, 2012
    Assignees: Institute of Radiation Medicine Academy of Military Medical Science, Beijing Sanly Sci-Tech Develop Inc. Ltd.
    Inventors: Zuze Wu, Aiping Yu, Chuanling Zhang, Zhongxiong Tang
  • Patent number: 8039513
    Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: October 18, 2011
    Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLA
    Inventors: Zhiyun Kang, Zuze Wu, Zhuangrong Sun, Zhongxiong Tang
  • Publication number: 20100234291
    Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
    Type: Application
    Filed: December 22, 2009
    Publication date: September 16, 2010
    Applicants: INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA, Beijing Sanly Sci-Tech Develop Inc. Ltd.
    Inventors: Zuze Wu, Aiping Yu, Chuanling Zhang, Zhongxiong Tang
  • Publication number: 20100144628
    Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 10, 2010
    Applicant: INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITA
    Inventors: Zuze Wu, Bingxing Shi, Chunping Cui, Shaojun Du, Danli Wu
  • Publication number: 20100113345
    Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
    Type: Application
    Filed: December 11, 2007
    Publication date: May 6, 2010
    Applicant: BEIJING SANLY SCI-TECH DEVELOP INC. LTD.
    Inventors: Zuze Wu, Aiping Yu, Chuanling Zhang, Zhongxiong Tang
  • Publication number: 20090076114
    Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
    Type: Application
    Filed: July 20, 2005
    Publication date: March 19, 2009
    Inventors: Zhiyun Kang, Zuze Wu, Zhuangrong Sun, Zhongxiong Tang
  • Patent number: 7384920
    Abstract: This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus associated diseases.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: June 10, 2008
    Assignees: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLA, Beijing Luyin Lihua Pharmaceutical Science and Technology Development Company Ltd
    Inventors: Junlin Li, Zuze Wu, Lizhen Yuan, Qiang Li, Zhongxiong Tang
  • Publication number: 20070060544
    Abstract: 4-nitro-2-[4?-methoxy)-phenoxy]-methane-sulfonanilide or the pharmaceutical acceptable salts or solvates or hydrates thereof are provided. Also provided is their mixture with povidone, phospholipids or cyclodextrin, as well as their pharmaceutical uses, particularly the use as a non-steroidal anti-inflammatory, analgetic agent.
    Type: Application
    Filed: December 30, 2003
    Publication date: March 15, 2007
    Inventors: Zhuangrong Sun, Zuze Wu, Zhongdong Tang, Alquan Liu
  • Publication number: 20060127389
    Abstract: This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
    Type: Application
    Filed: September 3, 2003
    Publication date: June 15, 2006
    Inventors: Bingxing Shi, Zuze Wu, Aiping Yu, Chunna Dong
  • Publication number: 20050020511
    Abstract: This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus associated diseases.
    Type: Application
    Filed: July 26, 2001
    Publication date: January 27, 2005
    Inventors: Junlin Li, Zuze Wu, Lizhen Yuan, Qiang Li, Zhongxiong Tang