Abstract: There is provided a matrix and cultivation system for anchorage dependent cells. The matrix is characterized by a substantially increased available effective surface area for cell attachment which is attained by resorting to the use of a fiber network or open-pore foams with suitable pore size. Attachment of the cells can be enhanced by modifying the surface of the substrate. One embodiment comprises a matrix in particle or flake form.

Abstract: The invention relates to packing material for use in the cultivation of anchorage-dependent cells, which require a solid surface for proliferation. The packing material of the invention is provided in the form of units of curved sheet material, which individual units generally have a thickness of about 0.05 mm to 0.25 mm, the other dimensions being of the order of one to a few millimeter maximum dimensions. Various shapes can be used, such as twisted rectangles, segments of cylinders, convulated ribbons, twisted shapes, ring shape and the like.