Patents by Inventor Zvi Hayouka

Zvi Hayouka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITES AND USES THEREOF
    Publication number: 20230256102
    Abstract: The invention generally concerns active peptide mixture and composites thereof.
    Type: Application
    Filed: June 18, 2020
    Publication date: August 17, 2023
    Inventors: Zvi Hayouka, Saul Burdman, David Avnir, Barak Menagen, Aya Brill, Tal Stern Bauer, Dafna Tamir Ariel, Heli Tamir Buchnik, Shiri Topman
  • ANTIMICROBIAL MATRIX AND USES THEREOF FOR ELIMINATING MICROORGANISMS
    Publication number: 20230076173
    Abstract: The present invention provides antimicrobial matrices comprising a water-insoluble polymer and a mixture comprising a plurality of synthetic peptides attached thereto via a linker, the peptides comprise cationic amino acid residues, hydrophobic amino acid residues, or combinations thereof, in random sequences. The invention further provides uses of the antimicrobial matrices for eliminating microorganisms, particularly pathogenic bacteria, from liquid or semi solid media including edible products or beverages.
    Type: Application
    Filed: February 9, 2021
    Publication date: March 9, 2023
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Zvi HAYOUKA
  • METHODS FOR DISRUPTING BIOFILMS
    Publication number: 20220016198
    Abstract: The present invention provides methods for disrupting biofilms and/or preventing the formation of biofilms along with medical items that contain a coating or covering made of compositions for achieving such disruption or prevention. In particular, the compositions of the present invention provide random-sequence peptide mixtures for use in disrupting bacterial biofilms; the random-sequence peptides having hydrophobic and/or cationic amino acids, wherein the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Inventor: Zvi HAYOUKA
  • Methods for disrupting biofilms
    Patent number: 11103547
    Abstract: Provided are methods for disrupting biofilms and/or preventing the formation of biofilms. Further provided are random-sequence peptide mixtures for use in disrupting bacterial biofilms. The random-sequence peptides include hydrophobic and/or cationic amino acids, and the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 31, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Zvi Hayouka
  • METHODS FOR DISRUPTING BIOFILMS
    Publication number: 20190038701
    Abstract: Provided are methods for disrupting biofilms and/or preventing the formation of biofilms. Further provided are random-sequence peptide mixtures for use in disrupting bacterial biofilms. The random-sequence peptides include hydrophobic and/or cationic amino acids, and the ratio of the total hydrophobic and cationic amino acids in the mixture is predefined.
    Type: Application
    Filed: February 2, 2017
    Publication date: February 7, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Zvi HAYOUKA
  • HIV-1 integrase derived peptides and compositions
    Patent number: 9738878
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: August 22, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • HIV-1 INTEGRASE DERIVED PEPTIDES AND COMPOSITIONS
    Publication number: 20160032263
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Application
    Filed: October 19, 2015
    Publication date: February 4, 2016
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding
    Patent number: 9163067
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 20, 2015
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • HIV-1 INTEGRASE DERIVED STIMULATORY PEPTIDES INTERFERING WITH INTEGRASE -- REV PROTEIN BINDING
    Publication number: 20110257082
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Application
    Filed: October 1, 2009
    Publication date: October 20, 2011
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter