Patents by Inventor Zvi Kam
Zvi Kam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160166582Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.Type: ApplicationFiled: February 23, 2016Publication date: June 16, 2016Applicant: Yeda Research and Development Co. Ltd.Inventors: Irina LAVELIN, Varda ROTTER, Moshe OREN, Ami NAVON, Zvi KAM, Benjamin GEIGER
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Patent number: 9289433Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.Type: GrantFiled: April 29, 2013Date of Patent: March 22, 2016Assignee: Yeda Research and Development Co. Ltd.Inventors: Irina Lavelin, Varda Rotter, Moshe Oren, Ami Navon, Zvi Kam, Benjamin Geiger
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Patent number: 8894227Abstract: A method and apparatus for correcting optical aberrations in an optical device using a deformable mirror. An actuator is provided which applies a deforming force to the deformable mirror. By selecting particular thickness profiles of the deformable mirror and force configurations of the actuator, the optical device can be configured to correct for different optical aberrations. The actuator may be configured to apply the deforming force peripherally, centrally, non-centrally or homogenously across the surface of the deformable mirror. The deformable mirror may be a flat disk mirror, a convex mirror, or a concave mirror, and may include a membrane having a variable flexibility. The optical device may be a wide-field microscope, an optical read/write device, laser tweezers, or any other optical device in which correction of optical aberrations is desirable.Type: GrantFiled: January 30, 2009Date of Patent: November 25, 2014Assignees: The Regents of the University of California, Yeda Research & Development Co. Ltd.Inventors: Peter Knor, David A. Agard, Zvi Kam, John W. Sedat
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Publication number: 20120083477Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.Type: ApplicationFiled: May 26, 2010Publication date: April 5, 2012Applicant: Yeda Research And Development Co. Ltd.Inventors: Irina Lavelin, Varda Rotter, Moshe Oren, Ami Navon, Zvi Kam, Benjamin Geiger
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Publication number: 20110134552Abstract: A method and apparatus for correcting optical aberrations in an optical device using a deformable mirror. An actuator is provided which applies a deforming force to the deformable mirror. By selecting particular thickness profiles of the deformable mirror and force configurations of the actuator, the optical device can be configured to correct for different optical aberrations. The actuator may be configured to apply the deforming force peripherally, centrally, non-centrally or homogenously across the surface of the deformable mirror. The deformable mirror may be a flat disk mirror, a convex mirror, or a concave mirror, and may include a membrane having a variable flexibility. The optical device may be a wide-field microscope, an optical read/write device, laser tweezers, or any other optical device in which correction of optical aberrations is desirable.Type: ApplicationFiled: January 30, 2009Publication date: June 9, 2011Inventors: Peter Kner, David A. Agard, Zvi Kam, John W. Sedat
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Patent number: 7764433Abstract: A system and method for correcting optical aberrations in optical devices, such as wide-field microscopes, optical tweezers and optical media devices, such as DVD drives. The system uses adaptive optics to correct optical aberrations, such as spherical and space-variant aberrations. Spherical aberrations can be corrected using one adaptive optical elements and space-variant aberrations can be corrected using numerous adaptive optical elements in tandem. The adaptive optical elements may be of several types, such as a liquid lenses, deformable membrane mirrors or various liquid crystal phase and amplitude modulators. Adaptive optics can also be used to simultaneously shift the focus of the optical device and correct optical aberrations.Type: GrantFiled: May 18, 2006Date of Patent: July 27, 2010Assignees: The Regents of the University of California, Yeda Research and Development Co., Ltd.Inventors: Zvi Kam, David A. Agard, Peter Kner, John W. Sedat
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Publication number: 20100022626Abstract: The present invention relates to a method of measuring cell migration, the method comprising (a) contacting a cell with a plurality of polystyrene non-fluorescent beads so as to generate a migratory track; and (b) analyzing at least one morphometric parameter of said migratory track, the morphomotric parameter being indicative of cell migration. The present invention also relates to methods of treating a medical condition associated with cell migration, the method comprising administering to a subject in need thereof a therapeutically effective amount of an agent capable of modulating the activity or expression of genes identified using the above assay, thereby treating the medical condition associated with cell migration.Type: ApplicationFiled: August 29, 2006Publication date: January 28, 2010Inventors: Benjamin Geiger, Zvi Kam, Suha Naffar-Abu-Amara
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Patent number: 7401056Abstract: In a method and apparatus for analyzing multivariable data sets, a general computerized platform is provided for evaluating the relationship between large number of measurements of sets of variables characterizing components of complex states of a system under induced stimulation or controlled conditions. The linked responses of variables and their temporal relations tell about the network of interactions and their hierarchy. Processing of data sets by a simple neural network gives a matrix of weight parameters, that allow to identify fingerprints of complex states characterized by patterns of measured variable and estimate the interactions between the components characterized by the measured variables. The results are provided numerically and by color-coded presentation indicating dominating relations between variables and strongly responding variables.Type: GrantFiled: May 29, 2007Date of Patent: July 15, 2008Assignee: Yeda Research and Development Co. Ltd.Inventor: Zvi Kam
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Publication number: 20070268592Abstract: A system and method for correcting optical aberrations in optical devices, such as wide-field microscopes, optical tweezers and optical media devices, such as DVD drives. The system uses adaptive optics to correct optical aberrations, such as spherical and space-variant aberrations. Spherical aberrations can be corrected using one adaptive optical elements and space-variant aberrations can be corrected using numerous adaptive optical elements in tandem. The adaptive optical elements may be of several types, such as a liquid lenses, deformable membrane mirrors or various liquid crystal phase and amplitude modulators. Adaptive optics can also be used to simultaneously shift the focus of the optical device and correct optical aberrations.Type: ApplicationFiled: May 18, 2006Publication date: November 22, 2007Inventors: Zvi Kam, David A. Agard, Peter Kner, John W. Sedat
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Publication number: 20070226157Abstract: In a method and apparatus for analyzing multivariable data sets, a general computerized platform is provided for evaluating the relationship between large number of measurements of sets of variables characterizing components of complex states of a system under induced stimulation or controlled conditions. The linked responses of variables and their temporal relations tell about the network of interactions and their hierarchy. Processing of data sets by a simple neural network gives a matrix of weight parameters, that allow to identify fingerprints of complex states characterized by patterns of measured variable and estimate the interactions between the components characterized by the measured variables. The results are provided numerically and by color-coded presentation indicating dominating relations between variables and strongly responding variables.Type: ApplicationFiled: May 29, 2007Publication date: September 27, 2007Inventor: Zvi KAM
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Patent number: 7224824Abstract: Apparatus for computational adaptive imaging comprises the following: an image information acquirer, which provides information relating to the refractive characteristics in a three-dimensional imaged volume; a ray tracer, which uses the information relating to the refractive characteristics to trace a multiplicity of rays from a multiplicity of locations in the three-dimensional imaged volume through the three-dimensional imaged volume, thereby providing a location dependent point spread function, and a deconvolver, which uses the location dependent point spread function, to provide an output image corrected for distortions due to variations in the refractive characteristics in the three-dimensional imaged volume.Type: GrantFiled: November 30, 1999Date of Patent: May 29, 2007Assignees: Yeda Research and Development Co., Ltd., The Regents of the University of CaliforniaInventors: Zvi Kam, John W Sedat, David A Agard, Bridget M Hanser
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Patent number: 7225172Abstract: In a method and apparatus for analyzing multivariable data sets, a general computerized platform is provided for evaluating the relationship between large number of measurements of sets of variables characterizing components of complex states of a system under induced stimulation or controlled conditions. The linked responses of variables and their temporal relations tell about the network of interactions and their hierarchy. Processing of data sets by a simple neural network gives a matrix of weight parameters, that allow to identify fingerprints of complex states characterized by patterns of measured variable and estimate the interactions between the components characterized by the measured variables. The results are provided numerically and by color-coded presentation indicating dominating relations between variables and strongly responding variables.Type: GrantFiled: November 26, 2002Date of Patent: May 29, 2007Assignee: Yeda Research and Development Co. Ltd.Inventor: Zvi Kam
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Publication number: 20060240404Abstract: A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle or structure of interest of the plurality of cells; and (c) isolating a cell or cells of the plurality of cells in which a cellular distribution and/or level of the subcellular organelle or structure of interest is altered to thereby isolate polypeptides capable of affecting the organization of the subcellular organelle or structure of interest.Type: ApplicationFiled: April 3, 2006Publication date: October 26, 2006Applicant: Yeda Research And Development Co. Ltd.Inventors: Benjamin Geiger, Zvi Kam, Eli Zamir, Alexander Bershadsky, Michael Shtutman, Avri Ben-Ze'ev
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Patent number: 7109459Abstract: An auto-focusing method and device are presented for determining an in-focus position of a sample supported on a substrate plate made of a material transparent with respect to incident electromagnetic radiation. The method utilizes an optical system capable of directing incident electromagnetic radiation towards the sample and collecting reflections of the incident electromagnetic radiation that are to be detected. A focal plane of an objective lens arrangement is located at a predetermined distance from a surface of the substrate, which is opposite to the sample-supporting surface of the substrate. A continuous displacement of the focal plane relative to the substrate along the optical axis of the objective lens arrangement is provided, while concurrently directing the incident radiation towards the sample through the objective lens arrangement to thereby focus the incident radiation to a location at the focal plane of the objective lens arrangement.Type: GrantFiled: March 13, 2003Date of Patent: September 19, 2006Assignee: Yeda Research and Development Company Ltd.Inventors: Zvi Kam, Benjamin Geiger
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Publication number: 20050121596Abstract: An auto-focusing method and device are presented for determining an in-focus position of a sample supported on a substrate plate made of a material transparent with respect to incident electromagnetic radiation. The method utilizes an optical system capable of directing incident electromagnetic radiation towards the sample and collecting reflections of the incident electromagnetic radiation that are to be detected. A focal plane of an objective lens arrangement is located at a predetermined distance from a surface of the substrate, which is opposite to the sample-supporting surface of the substrate. A continuous displacement of the focal plane relative to the substrate along the optical axis of the objective lens arrangement is provided, while concurrently directing the incident radiation towards the sample through the objective lens arrangement to thereby focus the incident radiation to a location at the focal plane of the objective lens arrangement.Type: ApplicationFiled: March 13, 2003Publication date: June 9, 2005Applicant: Yeda Research and Development Company Ltd.Inventors: Zvi Kam, Benjamin Geiger
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Publication number: 20040115659Abstract: A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle or structure of interest of the plurality of cells; and (c) isolating a cell or cells of the plurality of cells in which a cellular distribution and/or level of the subcellular organelle or structure of interest is altered to thereby isolate polypeptides capable of affecting the organization of the subcellular organelle or structure of interest.Type: ApplicationFiled: January 23, 2003Publication date: June 17, 2004Inventors: Benjamin Geiger, Zvi Kam, Eli Zamir, Alexander Bershadsky, Michael Shtutman, Avri Ben-Ze'ev
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Patent number: 6658142Abstract: Apparatus for computational adaptive imaging comprises the following: an image information acquirer, which provides information relating to the refractive characteristics in a three-dimensional imaged volume; a ray tracer, which uses the information relating to the refractive characteristics to trace a multiplicity of rays from a multiplicity of locations in the three-dimensional imaged volume through the three-dimensional imaged volume, thereby providing a location dependent point spread function; and a deconvolver, which uses the location dependent point spread function, to provide an output image corrected for distortions due to variations in the refractive characteristics in the three-dimensional imaged volume.Type: GrantFiled: January 27, 1999Date of Patent: December 2, 2003Assignees: Yeda Research and Development Co., Ltd., The Regents of the University of CaliforniaInventors: Zvi Kam, John W. Sedat, David A. Agard, Bridget M. Hanser
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Publication number: 20030158829Abstract: In a method and apparatus for analyzing multivariable data sets, a general computerized platform is provided for evaluating the relationship between large number of measurements of sets of variables characterizing components of complex states of a system under induced stimulation or controlled conditions. The linked responses of variables and their temporal relations tell about the network of interactions and their hierarchy. Processing of data sets by a simple neural network gives a matrix of weight parameters, that allow to identify fingerprints of complex states characterized by patterns of measured variable and estimate the interactions between the components characterized by the measured variables. The results are provided numerically and by color-coded presentation indicating dominating relations between variables and strongly responding variables.Type: ApplicationFiled: November 26, 2002Publication date: August 21, 2003Inventor: Zvi Kam