Patents by Inventor Zvi Loewy

Zvi Loewy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070292487
    Abstract: Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.
    Type: Application
    Filed: June 20, 2007
    Publication date: December 20, 2007
    Applicant: IZUN PHARMACEUTICALS CORPORATION
    Inventors: Zvi Loewy, William Levine, Aron Saffer
  • Publication number: 20060266715
    Abstract: The present invention provides for proteome fractionation through the separation and accumulation of subcellar organelles from a biological sample such that the subcellular organelles are highly enriched, substantially pure, and whose structural integrity and functions are well-preserved. The methods of the invention provide a manner by which to reduce the complexity of the proteome and facilitate the detection and isolation of difficult-to-study proteins, such as low-abundance proteins. The methods of the present invention for pre-fractioning proteomes of biological samples by parallel separation and isolation of subcellular organelles from the biological samples using continuous-flow ultracentrifugation are also easily and effectively scalable through adjustment to ultracentrifugation parameters, such as, for example, rotor speed, rotor size, rotor geometry.
    Type: Application
    Filed: November 4, 2005
    Publication date: November 30, 2006
    Inventor: Zvi Loewy
  • Publication number: 20040086918
    Abstract: The present invention relates to a novel method for the detection and characterization of an unknown nucleic acid-binding protein from a biological sample. More particularly, the method of the instant invention includes the steps of forming nucleic acid-protein complexes, the subsequent selective degradation of of unbound nucleic acid molecules, the detection of nucleic acid-protein complexes, and finally, the characterization of the nucleic acid-binding protein. Additionally, compositions and methods are provided in the present invention for detecting and characterizing unknown nucleic acid-binding proteins from biological samples using immobilized nucleic acid molecules in reaction vessels having a multitude of wells.
    Type: Application
    Filed: July 25, 2003
    Publication date: May 6, 2004
    Inventors: Zvi Loewy, Wayne Chaung, Raveendran Pottathil
  • Publication number: 20030203491
    Abstract: The present invention relates to a gravitational flow purification system. More particularly, the invention relates to a process for purifying or isolating one or more substances from samples comprising said substances. Even more particularly, the invention relates to purifying or isolating macromolecules from biological samples using a gravitational flow apparatus.
    Type: Application
    Filed: April 26, 2002
    Publication date: October 30, 2003
    Inventors: Zygmunt M. Andrevski, Ravi Mehra, Wayne Chaung, Zvi Loewy
  • Publication number: 20020031477
    Abstract: The present invention provides an integrated structural unit that includes a diagnostic form that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate, a deposit that is disposed on the substrate, and a spreading layer that overlies the deposit and is used to retain and spread a sample of liquid which is to be assayed. The deposit comprises a powder, including the active ingredient(s). The diagnostic form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
    Type: Application
    Filed: July 3, 2001
    Publication date: March 14, 2002
    Applicant: Delsys Pharmaceutical Corporation
    Inventors: Zvi Loewy, Dennis Lee Matthies
  • Patent number: 6287595
    Abstract: The present invention provides an integrated structural unit that includes a diagnostic form that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate, a deposit that is disposed on the substrate, and a spreading layer that overlies the deposit and is used to retain and spread a sample of liquid which is to be assayed. The deposit comprises a powder, including the active ingredient(s). The diagnostic form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: September 11, 2001
    Assignee: Delsys Pharmaceuticals Corporation
    Inventors: Zvi Loewy, Dennis Lee Matthies
  • Patent number: 5939261
    Abstract: The present invention relates to a method for capturing a class of nucleic acids comprising (a) providing a population of nucleic acids, wherein the population comprises the class; (b) binding a probe moiety to nucleic acids of the class, thereby forming one or more complexes, wherein the probe moiety is attached to a substrate; and (c) capturing the complex. The method can be implemented in certain embodiments in a structure comprised of one or more reservoirs, preferably wherein the reservoirs include one or more second chambers that are in communication with a first chamber. Preferably, the present invention is used to capture the class of nucleic acids that comprise regulatory elements included in a population of nucleic acids isolated from a cell, tissue, or organism. An alternative preferred embodiment of the present invention involves the capture of the class of nucleic acids that comprises certain repetitive elements included in a population of nucleic acids derived from an organism.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: August 17, 1999
    Assignee: Sarnoff Corporation
    Inventors: Zvi Loewy, Rajan Kumar
  • Patent number: 5939291
    Abstract: The nucleic acid amplification reactions of the present invention are conducted isothermally, using non-thermal denaturation procedures, such as occurs in chemical- or electrostatic-based denaturation. Embodiments are set forth for automated forms of the claimed procedures.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: August 17, 1999
    Assignee: Sarnoff Corporation
    Inventors: Zvi Loewy, Rajan Kumar
  • Patent number: 5914229
    Abstract: In one aspect, the present invention relates to methods of amplifying a target nucleic acid, the methods involving the production of a double-stranded promoter to provide for transcription of the target sequence, and the provision of a poly-A tail in the transcription product. In another aspect, the present invention relates to methods of detecting a target nucleic acid in a sample.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: June 22, 1999
    Assignee: Sarnoff Corporation
    Inventor: Zvi Loewy