Patents by Inventor Zvi Zelinger

Zvi Zelinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of backbone cyclic peptides
    Patent number: 5723575
    Abstract: Biologically active, backbone-cyclized peptides of the formula: ##STR1## wherein ?AA! or ?A.sup.1 A.sup.1 ! is a naturally occurring or synthetic amino acid residue, n or e is an integer of 1-10, m or d is 0 or an integer of 1-10, R is a naturally occurring or synthetic amino acid side-chain, E is a hydroxyl moiety or a carboxyl protecting group of a blocking group, optionally covalently attached to an insoluble polymeric support, and the circled line designates a spacer group of ##STR2## for formula I wherein M is --S--S--, --CO--NH-- or --S-- and p and q each is an integer of 2-10, or--(CH.sub.2).sub.p --(M).sub.x --Y (IV)for formula II wherein M is an amino or carboxyl group or a sulfur atom, p is an integer of 2-10, x is 0 or 1 and Y is a side-chain of a backbone amino acid. Also, processes for the preparation of these peptides and pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: March 3, 1998
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Chaim Gilon, Zvi Zelinger, Gerardo Byk