Abstract: In some embodiments, the distal end of an endodontic brush unevenly (e.g., not along a line perpendicular to the axis of the brush). Optionally, the uneven strands will contact the walls of a channel more evenly and/or will have an increased stirring effect than an evenly cut end may be cut using an abrasive cutter (e.g., a grinding wheel) and/or a laser and/or an electrical discharge machining (EDM) cutter. Optionally, a grinding wheel will rotate opposite the winding of the wire. Optionally, a round end may be formed on the wire. In some embodiment, a coupling between an endodontic brush and a handpiece in configured to be held totationally top the handpiece by friction and/or locked longitudinally into the handpiece by an interference element. In some embodiments, an edge of the brush is roughened. Optionally, the brush may be bent and/or eccentric.