Stent graft with fenestration lock and methods of use
A stent graft includes a luminal graft component defining at least one fenestration. At least one ligature traverses the fenestration and at least partially defines an opening within the fenestration that secures a branch prosthesis. The stent graft is implanted in a patient to thereby treat an arterial aneurysm, such as an aortic aneurysm in a region of the aorta that includes at least one arterial branch, including juxtarenal and short-neck aortic aneurysms.
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This application is a continuation of International Application No. PCT/US2018/019352, which designated the United States and was filed on Feb. 23, 2018, published in English, which claims the benefit of U.S. Provisional Application No. 62/463,054, filed on Feb. 24, 2017. The entire teachings of the above applications are incorporated herein by reference.
BACKGROUNDFenestrated endovascular aortic repair (FEVAR) is a minimally invasive procedure to treat arterial aneurysms that span blood vessels that supply blood to vital organs including the kidneys, intestine and liver. Endovascular grafts employed in FEVAR define fenestrations for insertion of branch prostheses that serve as passageways for blood flow through arterial branches to vital organs following implantation of the endovascular graft. Maximizing blood flow to vital organs and minimizing endoleaks following repair of arterial aneurysms with fenestrated vascular prostheses, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms, present medical challenges that must be overcome if more invasive surgical intervention is to be avoided.
Therefore, a need exits for new and improved endovascular repair devices and methods of their use to treat arterial pathologies, such as juxtarenal and short-neck abdominal aortic aneurysms.
SUMMARYThe present invention relates to stent grafts for use in treating and repairing arterial vascular damage, such as vascular damage associated with arterial aneurysms including juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms, having associated arterial branches supplying blood to vital organs and tissues.
In one embodiment, the invention is a stent graft that includes a luminal graft component having a proximal open end, a distal open end, and defining a main lumen extending from the proximal open end to the distal open end. The luminal graft component defines at least one fenestration. At least one ligature traverses the at least one fenestration, wherein the ligature, along or in combination with the luminal graft component, constitutes a fenestration lock at the fenestration, whereby a branch prosthesis can be secured by the fenestration lock.
In another embodiment, the invention is a method for treating an arterial aneurysm that includes delivering a stent graft through an artery to an aneurysm of a patient, the aneurysm spanning a region of an artery that spans an associated arterial branch. The stent graft includes a luminal graft component having a proximal open end, a distal open end, and a main lumen extending from the proximal open end to the distal open end, and wherein the luminal graft component defines at least one fenestration. At least one ligature traverses the fenestration, the ligature alone or in combination with the luminal graft component, constitutes a fenestration lock at the fenestration, whereby a proximal end or a distal end of a branch prosthesis can be secured by the fenestration lock. The fenestration is substantially aligned with the associated arterial branch at the aneurysm site of the patient and then the stent graft is at least partially released from a delivery device. At least one branch prosthesis is delivered through the proximal open end or the distal open end of the luminal graft component of the stent graft, and through the opening and to the associated arterial branch, thereby treating the arterial aneurysm.
The vascular prostheses of the invention have several advantages by, for example, providing the surgeon with increased flexibility to accommodate anatomical variations in the size of arterial branches at an aneurysm. Specifically, the fenestration lock in a luminal graft can better secure a branch prosthesis during implantation. The vascular prostheses of the invention also have the additional advantage of improving a seal between a fenestration of the stent graft of the invention and a branch prosthesis by limiting motion of the branch prostheses, following insertion of the branch prosthesis through the fenestration, thereby significantly reducing the incidence and severity of endoleaks and resulting complications.
The foregoing will be apparent from the following more particular description of example embodiments, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating embodiments.
The invention is generally directed to stent graft and methods for treating and repairing aortic vascular damage, such as vascular damage associated with an aortic aneurysm in regions of the aorta having arterial branches to vital organs and tissues, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms.
The features and other details of the invention, either as steps of the invention or as combinations of parts of the invention will now be more particularly described and pointed out in the claims. It will be understood that the particular embodiments of the invention are shown by way of illustration and not as limitations of the invention. The principle features of this invention can be employed in various embodiments without departing from the scope of the invention.
A description of example embodiments of the invention follows.
When reference is made herein to a prosthesis, also referred to herein as a “stent graft,” “stent graft prosthesis,” or “stent graft,” to be delivered, or implanted in a patient, the word “proximal” means that portion of the prosthesis or component of the prosthesis that is relatively close to the heart of the patient and “distal” means that portion of the prosthesis or component of the prosthesis that is relatively far from the heart of the patient. A “longitudinal axis,” as that term is defined herein, means an axis along a lengthwise direction of a body that also passes through a center of gravity of the body.
When, however, reference is made to a delivery system or a component of a delivery system employed to deliver, or implant, a prosthesis, the word, “proximal,” as employed herein, means closer to the clinician using the delivery system. When reference is made to a delivery system or a component of a delivery system, “distal,” as that term is employed herein, means, further away from the clinician using the delivery system.
For clarity, the word “proximate” means “close to,” as opposed to the meanings ascribed to “proximal” or “distal” described above with respect to either the prosthesis or a delivery system.
In an embodiment, the stent graft is shown in
Ligatures 22 traverse fenestration 20 of luminal graft component 12 to thereby at least partially define opening 24, within fenestration 20. As shown later, a branch prosthesis can be secured within fenestration 20 by plurality of ligatures 22, ligatures 22 and a portion of the periphery of fenestration 20 thereby constituting a fenestration lock. Ligatures 22 are affixed to luminal graft component 12 and fenestration 20 by a suitable method, such as is known to those skilled in the art. Examples of a suitable method include use of sutures or a biocompatible adhesive. Ligatures 22 are fabricated of a suitable material such as is known in the art, including, for example, at least one member selected from the group consisting of sutures, cloth, metal, and an elastic material, such as a biocompatible rubber band or latex. Examples of suitable sutures include sutures fabricated of at least one member of the group consisting of PTFE, ePTFE, polyglycolic acid, polylactic acid, monocryl and polydioxane, non-absorbable nylon, polyester, polyvinylidene difluoride (PVDF) and polypropylene. Suitable rubber bands can include, for example, rubber bands formed of natural rubber or a synthetic rubber. Metal can include wires, such as an elastic material or shape memory alloy. Metal ligatures can include a shape memory alloy, such as nitinol, and stainless steel.
Optionally, stent graft 10 includes radially expanding bare stent 26 having proximal apices 28 and distal apices 30. Proximal apices 28 extend proximally beyond proximal open end 14 of luminal graft component 12. In an embodiment, proximal apices 28 include a fixation component, such as at least one barb 27. Distal apices 30 of bare stent 26 are fixed to proximal open end 14 of luminal graft component 12.
Suitable radiopaque markers 32, such as those known to those skilled in the art, are secured, such as by suturing or use of biocompatible adhesive, to at least one of proximal open end 14, distal open end 16, the perimeter of fenestration 20 of luminal graft component 12, and fenestration lock 24, which is constituted by ligatures 22 and a portion of the perimeter of fenestration 20. Radiopaque markers 32, in one embodiment, are incorporated into ligatures 22. In an embodiment, ligatures 22, radiopaque markers 32 and ring 36 (described in detail below) include a radiopaque material, such as at least one radiopacifier selected from the group consisting of barium sulfate, bismuth, tungsten, platinum, platinum-iridium, tantalum and tantalum-tungsten.
Stent graft 10 includes plurality of stents 34 distributed longitudinally along luminal graft component 12. Stents 34 are formed from a suitable material, such as is known to those skilled in the art, including, for example, stainless steel or a shape-memory alloy, such as Nitinol. Stents 34 are fixed to luminal graft component by suitable means known to those skilled in the art, such as by suturing or affixation by employment of biocompatible adhesive.
As shown in detail in
Returning to
In another embodiment of a method of the invention, described with reference to
Stent graft 100 includes luminal graft component 130 that has proximal end opening 132, distal end opening 134, and defines main lumen 139.
Each branch prosthesis 124, 126, 128, 130 is delivered by a respective branch prosthesis delivery device, such as shown in
Although not shown, the distal end of the vascular prostheses of the invention can be bifurcated and additional branch prostheses can be implanted into the distal end of the bifurcated stent graft.
Vascular prostheses of the invention can be implanted, for example, by transfemoral access. Additional vascular repair devices that are directed into the vascular prostheses of the invention can be implanted, for example, by supraaortic vessel access (e.g., through the brachial artery), or by transfemoral access or access from some other branch or branches of major blood vessels including peripheral blood vessels.
The teachings of all patents, published applications and references cited herein are incorporated by reference in their entirety. The relevant teachings of U.S. Pat. Nos. 8,292,943; 7,763,063; 8,308,790; 8,070,790; 8,740,963; 8,007,605; 9,320,631; 8,062,349; 9,198,786; 8,062,345; 9,561,124; 9,173,755; 8,449,595; 8,636,788; 9,333,104; 9,408,734; 9,408,735; 8,500,792; 9,220,617; 9,364,314; 9,101,506; 8,998,970; 9,554,929; 9,439,751; 9,592,112; 9,655,712, 9,827,123, 9,877,857, 9,907,686; U.S. patent application Ser. Nos. 14/575,673; 15/166,818; 15/167,055; 14/272,818; 14/861,479; 15/478,424; 15/478,737; 15/587,664; 15/604,032; 15/672,404; 15/816,772; 15/839,272; 15/417,467; PCT/US2017/025844; PCT/US2017/025849; PCT/US2017/025912; PCT/US2017/034223 and PCT/US2017/046062, are also incorporated by reference in their entirety.
The relevant teachings of the “Delivery System For Radially Constricting a Stent Graft and Method of Use,” by Eduardo Alejandro Garcia, filed on Feb. 23, 2018; “System and Method to Radially Constrict Stent Graft,” by Samuel Arbefeuille, filed on Feb. 23, 2018; “Delivery System and Method to Radially Constrict a Stent Graft,” by Timothy Lostetter, filed on Feb. 23, 2018; “Vascular Prosthesis with Moveable Fenestration and Method of Use,” by Samuel Arbefeuille, filed on Feb. 23, 2018; “Stent Graft Delivery System with Constricted Sheath and Method of Use,” by Timothy Lostetter, filed on Feb. 23, 2018; “Stent Graft, Delivery System and Methods of Use,” by Samuel Arbefeuille and Nico Bahar, filed on Feb. 23, 2018; “Vascular Prosthesis with Crimped Adapter and Methods of Use,” by Samuel Arbefeuille, filed on Feb. 23, 2018; “Radially Adjustable Stent Graft Delivery System and Method of Use,” by Samuel Arbefeuille, Eduardo Alejandro Garcia and Scott L. Rush, filed on Feb. 23, 2018; “Vascular Prosthesis with Fenestration Ring and Methods of Use,” by Timothy Lostetter, filed on Feb. 23, 2018; “Distal Torque Component, Delivery System and Method of Using Same,” by Samuel Arbefeuille, filed on Feb. 23, 2018, are also incorporated by reference in their entirety.
While example embodiments have been particularly shown and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the embodiments encompassed by the appended claims.
Claims
1. A stent graft, comprising:
- a) a luminal graft component having a proximal open end, a distal open end, and defining a main lumen extending from the proximal open end to the distal open end, the luminal graft component defining at least one fenestration;
- b) at least one ligature completely traversing the at least one fenestration, the at least one ligature, in combination with the luminal graft component, constituting at least one fenestration lock at the at least one fenestration, whereby a branch prosthesis can be secured by the at least one fenestration lock; and
- c) at least one fenestration ring encompassing the at least one fenestration and fixed to the luminal graft component, the at least one fenestration ring defining a variable fenestration ring diameter, wherein the fenestration ring diameter can expand upon insertion of a branch prosthesis through the at least one fenestration ring during implantation of the branch prosthesis.
2. The stent graft of claim 1, wherein the at least one ligature is at least one member selected from the group consisting of sutures, rubber bands, latex, cloth, and metal.
3. The stent graft of claim 1, wherein the at least one ligature includes an elastic material.
4. The stent graft of claim 1, wherein the at least one ligature includes a shape memory alloy.
5. The stent graft of claim 4, wherein the shape memory alloy is Nitinol.
6. The stent graft of claim 1, wherein the at least one ligature includes at least two ligatures that are substantially parallel to each other.
7. The stent graft of claim 1, wherein the at least one ligature is a plurality of ligatures that includes ligatures that are substantially parallel to each other and ligatures that are substantially perpendicular to the substantially parallel ligatures.
8. The stent graft of claim 1, wherein the at least one ligature is a plurality of ligatures that completely form the at least one fenestration lock.
9. The stent graft of claim 1, further including a plurality of radially self-expanding stents distributed longitudinally along the luminal graft component, wherein the at least one fenestration is between two of the plurality of radially self-expanding stents.
10. The stent graft of claim 1, further including a radially self-expanding stent along the circumference of the at least one fenestration.
11. The stent graft of claim 1, further including a radially self-expanding bare stent having proximal and distal apices, the proximal apices extending beyond the proximal open end of the luminal graft component and the distal apices being affixed to the proximal open end of the luminal graft component.
12. The stent graft of claim 1, further including at least one branch prosthesis having a proximal end and a distal end, either the proximal end or the distal end of the branch prosthesis extending through the at least one fenestration lock of the luminal graft component.
13. A stent graft, comprising:
- a) a luminal graft component having a proximal open end, a distal open end, and defining a main lumen extending from the proximal open end to the distal open end, the luminal graft component defining at least one fenestration; and
- b) at least one ligature completely traversing the at least one fenestration, the at least one ligature, alone or in combination with the luminal graft component, constituting at least one fenestration lock at the at least one fenestration, whereby a branch prosthesis can be secured by the at least one fenestration lock; and
- c) at least one fenestration ring encompassing the at least one fenestration and fixed to the luminal graft component, the at least one fenestration ring defining a variable fenestration ring diameter and including a main component having two non-overlapping opposing ends, and a connecting component that bridges the two non-overlapping opposing ends to thereby complete configuration of the main component as a ring, wherein the fenestration ring diameter can expand upon insertion of a branch prosthesis through the at least one fenestration ring during implantation of the branch prosthesis.
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Type: Grant
Filed: Apr 23, 2019
Date of Patent: Mar 22, 2022
Patent Publication Number: 20190247179
Assignee: Bolton Medical, Inc. (Sunrise, FL)
Inventor: Timothy Lostetter (Sunrise, FL)
Primary Examiner: Erich G Herbermann
Application Number: 16/392,443
International Classification: A61F 2/02 (20060101); A61F 2/07 (20130101); A61F 2/06 (20130101); A61F 2/82 (20130101); A61F 2/848 (20130101);