Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins

Abstract

The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.

Description

[0001] This is a continuation-in-part of U.S. application Ser. No. 08/446,872 filed Feb. 2, 1995 which is a continuation-in-part of U.S. application Ser. No. 08/192,325 filed Feb. 4, 1994 which are incorporated herein by reference.

FIELD OF THE INVENTION

[0002] The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a medium which includes a chimera protein comprising a variant of human interleukin-3 (hIL-3) joined with or without a linker to a second colony stimulating factors, cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants and the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.

BACKGROUND OF THE INVENTION

[0003] Colony stimulating factors, cytokines, lymphokines, interleukins or hematopoietic growth factors (herein collectively referred to as “hematopoietic growth factors”) which stimulate the differentiation and/or proliferation of bone marrow cells have generated much interest because of their therapeutic potential for restoring depressed levels of hematopoietic stem cell-derived cells. Hematopoietic growth factors in both human and murine systems have been identified and distinguished according to their activities. For example, granulocyte-CSF (G-CSF) and macrophage-CSF (M-CSF) stimulate the in vitro formation of neutrophilic granulocyte and macrophage colonies, respectively while GM-CSF and interleukin-3 (IL-3) have broader activities and stimulate the formation of both macrophage, neutrophilic and eosinophilic granulocyte colonies. IL-3 also stimulates the formation of mast, megakaryocyte and pure and mixed erythroid colonies.

[0004] Because of its ability to stimulate the proliferation of a number of different cell types and to support the growth and proliferation of progenitor cells, IL-3 has potential for therapeutic use in restoring hematopoietic cells to normal amounts in those cases where the number of cells has been reduced due to diseases or to therapeutic treatments such as radiation and/or chemotherapy.

[0005] Interleukin-3 (IL-3) is a hematopoietic growth factor which has the property of being able to promote the survival, growth and differentiation of hematopoietic cells. Among the biological properties of IL-3 are the ability (a) to support the growth and differentiation of progenitor cells committed to all, or virtually all, blood cell lineages; (b) to interact with early multipotential stem cells; (c) to sustain the growth of pluripotent precursor cells; (d) to stimulate proliferation of chronic myelogenous leukemia (CML) cells; (e) to stimulate proliferation of mast cells, eosinophils and basophils; (f) to stimulate DNA synthesis by human acute myelogenous leukemia (AML) cells; (g) to prime cells for production of leukotrienes and histamines; (h) to induce leukocyte chemotaxis; and (i) to induce cell surface molecules needed for leukocyte adhesion.

[0006] Mature human interleukin-3 (hIL-3) consists of 133 amino acids. It has one disulfide bridge and two potential glycosylation sites (Yang, et al., CELL 47:3 (1986)).

[0007] Murine IL-3 (mIL-3) was first identified by Ihle, et al., J. IMMUNOL. 126:2184 (1981) as a factor which induced expression of a T cell associated enzyme, 20.-hydroxysteroid dehydrogenase. The factor was purified to homogeneity and shown to regulate the growth and differentiation of numerous subclasses of early hematopoietic and lymphoid progenitor cells.

[0008] In 1984, cDNA clones coding for murine IL-3 were isolated (Fung, et al., NATURE 307:233 (1984) and Yokota, et al., PROC. NATL. ACAD. SCI. USA 81:1070 (1984)). The murine DNA sequence coded for a polypeptide of 166 amino acids including a putative signal peptide.

[0009] The gibbon IL-3 sequence was obtained using a gibbon cDNA expression library. The gibbon IL-3 sequence was then used as a probe against a human genomic library to obtain a human IL-3 sequence.

[0010] Gibbon and human genomic DNA homologues of the murine IL-3 sequence were disclosed by Yang, et al., CELL 47:3 (1986). The human sequence reported by Yang, et al. included a serine residue at position 8 of the mature protein sequence. Following this finding, others reported isolation of Pro8 hIL-3 cDNAs having proline at position 8 of the protein sequence. Thus it appears that there may be two allelic forms of hIL-3.

[0011] Dorssers, et al., GENE 55:115 (1987), found a clone from a human cDNA library which hybridized with mIL-3. This hybridization was the result of the high degree of homology between the 3′ noncoding regions of mIL-3 and hIL-3. This cDNA coded for an hIL-3 (Pro8) sequence.

[0012] U.S. Pat. No. 4,877,729 and U.S. Pat. No. 4,959,454 disclose human IL-3 and gibbon IL-3 cDNAs and the protein sequences for which they code. The hIL-3 disclosed has serine rather than proline at position 8 in the protein sequence.

[0013] Clark-Lewis, et al., SCIENCE 231:134 (1986) performed a functional analysis of murine IL-3 analogs synthesized with an automated peptide synthesizer. The authors concluded that the stable tertiary structure of the complete molecule was required for full activity. A study on the role of the disulfide bridges showed that replacement of all four cysteines by alanine gave a molecule with 1/500th the activity as the native molecule. Replacement of two of the four Cys residues by Ala(Cys79, Cys140→Ala79, Ala140) resulted in an increased activity. The authors concluded that in murine IL-3 a single disulfide bridge is required between cysteines 17 and 80 to get biological activity that approximates physiological levels and that this structure probably stabilizes the tertiary structure of the protein to give a conformation that is optimal for function. (Clark-Lewis, et al., PROC. NATL. ACAD. SCI. USA 85:7897 (1988)).

[0014] International Patent Application (PCT) WO 88/00598 discloses gibbon- and human-like IL-3. The hIL-3 contains a Ser8→Pro8 replacement. Suggestions are made to replace Cys by Ser, thereby breaking the disulfide bridge, and to replace one or more amino acids at the glycosylation sites.

[0015] EP-A-0275598 (WO 88/04691) illustrates that Ala1 can be deleted while retaining biological activity. Some mutant hIL-3 sequences are provided, e.g., two double mutants, Ala1→Asp1, Trp13→Arg13 (pGB/IL-302) and Ala1→Asp1, Met3→Thr3 (pGB/IL-304) and one triple mutant Ala1→Asp1, Leu9→Pro9, Trp13→Arg13 (pGB/IL-303).

[0016] WO 88/05469 describes how deglycosylation mutants can be obtained and suggests mutants of Arg54Arg55 and Arg108Arg109Lys110 might avoid proteolysis upon expression in Saccharomyces cerevisiae by KEX2 protease. No mutated proteins are disclosed. Glycosylation and the KEX2 protease activity are only important, in this context, upon expression in yeast.

[0017] WO 88/06161 mentions various mutants which theoretically may be conformationally and antigenically neutral. The only actually performed mutations are Met2→Ile2 and Ile131→Leu131. It is not disclosed whether the contemplated neutralities were obtained for these two mutations.

[0018] WO 91/00350 discloses nonglycosylated hIL-3 analog proteins, for example, hIL-3 (Pro8Asp15Asp70), Met3 rhuIL-3 (Pro8Asp15Asp70); Thr4 rhuIL-3 (Pro8Asp15Asp70)and Thr6 rhuIL-3 (Pro8Asp15Asp70). It is said that these protein compositions do not exhibit certain adverse side effects associated with native hIL-3 such as urticaria resulting from infiltration of mast cells and lymphocytes into the dermis. The disclosed analog hIL-3 proteins may have N termini at Met3, Thr4, or Thr6.

[0019] WO 91/12874 discloses cysteine added variants (CAVs) of IL-3 which have at least one Cys residue substituted for a naturally occurring amino acid residue.

[0020] U.S. Pat. No. 4,810,643 discloses the DNA sequence encoding human G-CSF.

[0021] WO 91/02754 discloses a fusion protein composed of GM-CSF and IL-3 which has increased biological activity compared to GM-CSF or IL-3 alone. Also disclosed are nonglycosylated IL-3 and GM-CSF analog proteins as components of the fusion.

[0022] WO 92/04455 discloses fusion proteins composed of IL-3 fused to a lymphokine selected from the group consisting of IL-3, IL-6, IL-7, IL-9, IL-11, EPO and G-CSF.

[0023] WO 92/06006 relates to hematopoietic molecules comprising an early acting factor (IL-3 or GM-CSF) and a late acting factor (EPO, IL-5, G-CSF or M-CSF) and the in vivo use for treating hematopoietic disorders.

[0024] Hematopoietic growth factors, such as hIL-3, have been administered alone, co-administered with other hematopoietic growth factors, or in combination with bone marrow transplants subsequent to high dose chemotherapy to treat the neutropenia and thrombocytopenia which are often the result of such treatment. However the period of severe neutropenia and thrombocytopenia may not be totally eliminated. The myeloid lineage, which is comprised of monocytes (macrophages), granulocytes (including neutrophils) and megakaryocytes, is critical in preventing infections and bleeding which can be life-threatening. Neutropenia and thrombocytopenia may also be the result of disease, genetic disorders, drugs, toxins, radiation and many therapeutic treatments such as conventional oncology therapy.

[0025] Bone marrow transplants have been used to treat this patient population. However, several problems are associated with the use of bone marrow to reconstitute a compromised hematopoietic system including: 1) the number of stem cells in bone marrow or other is limited, 2) Graft Versus Host Disease, 3) graft rejection and 4) possible contamination with tumor cells. Stem cells make up a very small percentage of the nucleated cells in the bone marrow, spleen and peripheral blood. It is clear that a dose response exits such that a greater number of stem cells will enhance hematopoietic recovery. Therefore, the use of hematopoietic cells that have been expanded ex-vivo should enhance hematopoietic recovery and patient survival. Bone marrow from an allogeneic donor has been used to provide bone marrow for transplant. However, Graft Versus Host Disease and graft rejection limit bone marrow transplantation even in recipients with HLA-matched sibling donors. An alternative to allogenic bone marrow transplants is autologous bone marrow transplants. In autologous bone marrow transplants, some of the patient's own marrow is harvested prior to myeloablative therapy, e.g. high dose chemotherapy, and is transplanted back into the patient afterwards. Autologous transplants eliminate the risk of Graft Versus Host Disease and graft rejection. However, autologous bone marrow transplants still present problems in terms of the limited number of stems cells in the marrow and possible contamination with tumor cells.

[0026] The limited number of stem cells may be overcome by ex-vivo expansion of the stem cells. In addition, stem cells can be specifically isolated selected based on the presence of specific surface antigen such as CD34+ in order to decrease tumor cell contamination of the marrow graft.

[0027] The following patents contain further details on separating stem cells, CD34+ cells, culturing the cells with hematopoietic growth factors, the use of the cells for the treatment of patients with hematopoietic disorders and the use of hematopoietic factors for cell expansion and gene therapy.

[0028] U.S. Pat. No. 5,061,620 relates to compositions comprising human hematopoietic stem cells provided by separating the stem cells from dedicated cells.

[0029] U.S. Pat. No. 5,199,942 describes a method for autologous hematopoietic cell transplantation comprising: (1) obtaining hematopoietic progenitor cells from a patient; (2) ex-vivo expansion of cells with a growth factor selected from the group consisting of IL-3, flt3 ligand, c-kit ligand, GM-CSF, IL-1, GM-CSF/IL-3 fusion protein and combinations thereof; (3) administering cellular preparation to a patient.

[0030] U.S. Pat. No. 5,240,856 relates to a cell separator that includes apparatus for automatically controlling the cell separation process.

[0031] U.S. Pat. No. 5,409,813 describes methods of positive and negative selection of a cell population from a mixture of cell populations utilizing a magnetically stabilized fluidized bed.

[0032] U.S. Pat. No. 5,409,825 relates to a method of growing hematopoietic stem cells in a liquid culture medium using mast cell growth factor (MGF) and optionally at least one cytokine selected from the group consisting of IL-3, GM-CSF and IL-3/GM-CSF fusion protein.

[0033] U.S. Pat. No. 5,459,069 relates to devices for maintaining and growing human stem cells and/or hematopoietic cells in culture.

[0034] U.S. Pat. No. 5,541,103 describes peripheral blood progenitor cells obtained by enriching blood progenitors expressing the cd34 antigen and culture the cells in a growth medium consisting of IL-1, IL-3, IL-6, erythropoietin and stem cell growth factor.

[0035] U.S. Pat. No. 5,464,753 describes a method of purifying pluripotent hematopoietic stem cells expressing P-glycoprotein from a mixture of blood or bone marrow cells.

[0036] U.S. Pat. No. 5,547,687 relates to a method of enriching CD34 cells from a cell mixture by density centrifugation.

[0037] U.S. Pat. No. 5,571,686 depicts the use of megapoietin (c-mpl ligand) for the in vitro expansion of stem cells as a source of platelets for transplantation and for increasing the storage life of platelets.

[0038] WO 91/16116 describes devices and methods for selectively isolating and separating target cells from a mixture of cells.

[0039] WO 91/18972 describes methods for in vitro culturing of bone marrow, by incubating suspension of bone marrow cells, using a hollow fiber bioreactor.

[0040] WO 92/18615 relates to a process for maintaining and expanding bone marrow cells, in a culture medium containing specific mixtures of cytokines, for use in transplants.

[0041] WO 93/08268 describes a method for selectively expanding stem cells, comprising the steps of (a) separating CD34+ stem cells from other cells and (b) incubating the separated cells in a selective medium, such that the stem cells are selectively expanded.

[0042] WO 93/18136 describes a process for in vitro support of mammalian cells derived from peripheral blood.

[0043] WO 93/18648 relates to a composition comprising human neutrophil precursor cells with a high content of myeloblasts and promyelocytes for treating genetic or acquired neutropenia.

[0044] WO 94/08039 describes a method of enrichment for human hematopoietic stem cells by selection for cells which express c-kit protein.

[0045] WO 94/11493 describes a stem cell population that are CD34+ and small in size, which are isolated using a counterflow elutriation method.

[0046] WO 94/27698 relates to a method combining immunoaffinity separation and continuous flow centrifugal separation for the selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture.

[0047] WO 94/25848 describes a cell separation apparatus for collection and manipulation of target cells.

[0048] The long term culturing of highly enriched CD34+ precursors of hematopoietic progenitor cells from human bone marrow in cultures containing IL-1&agr;, IL-3, IL-6 or GM-CSF is discussed in Brandt et al., J. Clin. Invest. 86:932-941, 1990.

SUMMARY OF THE INVENTION

[0049] The present invention encompasses the use of chimera proteins, comprising a recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) joined with or without a linker to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin, hematopoietic growth factor (herein collectively referred to as “hematopoietic growth factors”) or IL-3 variant, for the ex-vivo expansion of hematopoietic cells. These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at either/or both the N- and C-termini. This invention encompasses mixed function hematopoietic growth factors formed from covalently linked polypeptides, each of which may act through a different and specific cell receptor to initiate complementary biological activities.

[0050] Novel compounds of this invention are represented by the formulas

[0051] R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

[0052] where R1 is a hIL-3 variant which contains multiple amino acid substitutions and which may have portions of the hIL-3 molecule deleted, R2 is an IL-3, IL-3 variant or hematopoietic growth factor with a different but complementary activity. The R1 polypeptide is joined either directly or through a linker segment to the R2 polypeptide. Thus L represents a chemical bond or polypeptide segment to which both R1 and R2 are joined. Preferably, these mutant IL-3 polypeptides of the present invention contain four or more amino acids which differ from the amino acids found at the corresponding positions in the native hIL-3 polypeptide.

[0053] These chimera molecules may be characterized by having the usual activity of both of the peptides forming the chimera molecule or it may be further characterized by having a biological or physiological activity greater than simply the additive function of the presence of IL-3 or the second hematopoietic growth factor alone. The chimera molecule may also unexpectedly provide an enhanced effect on the activity or an activity different from that expected by the presence of IL-3 or the second hematopoietic growth factor or IL-3 variant. The chimera molecule may also have an improved activity profile which may include reduction of undesirable biological activities associated with native hIL-3.

[0054] The present invention also includes mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus and/or from 1 to 15 amino acids have been deleted from the C-terminus, containing multiple amino acid substitutions, to which a second hematopoietic growth factor or IL-3 variant has been joined. Preferred chimera molecules of the present invention are composed of hIL-3 variants in which amino acids 1 to 14 have been deleted from the N-terminus, amino acids 126 to 133 have been deleted from the C-terminus, and contains from about four to about twenty-six amino acid substitutions in the polypeptide sequence joined to second hematopoietic growth factor or IL-3 variant.

[0055] The present invention includes methods for selective ex vivo expansion of stem cells, comprising the steps of; (a) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

[0056] R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

[0057] wherein R1 is a human. interleukin-3 mutant polypeptide of SEQ ID NO: 1

[0058] wherein

[0059] Xaa at position 17 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

[0060] Xaa at position 18 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

[0061] Xaa at position 19 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

[0062] Xaa at position 20 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

[0063] Xaa at position 21 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

[0064] Xaa at position 22 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val or Gly;

[0065] Xaa at position 23 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

[0066] Xaa at position 24 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

[0067] Xaa at position 25 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

[0068] Xaa at position 26 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

[0069] Xaa at position 27 is Leu, Gly, Arg, Thr, Ser, or Ala;

[0070] Xaa at position 28 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

[0071] Xaa at position 29 is Gln, Asn, Leu, Pro, Arg, or Val;

[0072] Xaa at position 30 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

[0073] Xaa at position 31 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

[0074] Xaa at position 32 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

[0075] Xaa at position 33 is Pro, Leu, Gln, Ala, Thr, or Glu;

[0076] Xaa at position 34 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

[0077] Xaa at position 35 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

[0078] Xaa at position 36 is Asp, Leu, or Val;

[0079] Xaa at position 37 is Phe, Ser, Pro, Trp, or Ile;

[0080] Xaa at position 38 is Asn, or Ala;

[0081] Xaa at position 40 is Leu, Trp, or Arg;

[0082] Xaa at position 41 is Asn, Cys, Arg, Leu, His, Met, or Pro;

[0083] Xaa at position 42 is Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met or Ala;

[0084] Xaa at position 43 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

[0085] Xaa at position 44 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

[0086] Xaa at position 45 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu or His;

[0087] Xaa at position 46 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

[0088] Xaa at position 47 is Ile, Gly, Val, Ser, Arg, Pro, or His;

[0089] Xaa at position 48 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

[0090] Xaa at position 49 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

[0091] Xaa at position 50 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

[0092] Xaa at position 51 is Asn, Arg, Met, Pro, Ser, Thr, or His;

[0093] Xaa at position 52 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

[0094] Xaa at position 53 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

[0095] Xaa at position 54 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

[0096] Xaa at position 55 is Arg, Thr, Val, Ser, Leu, or Gly;

[0097] Xaa at position 56 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

[0098] Xaa at position 57 is Asn or Gly;

[0099] Xaa at position 58 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

[0100] Xaa at position 59 is Glu, Tyr, His, Leu, Pro, or Arg;

[0101] Xaa at position 60 is Ala, Ser, Pro, Tyr, Asn, or Thr;

[0102] Xaa at position 61 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

[0103] Xaa at position 62 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

[0104] Xaa at position 63 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

[0105] Xaa at position 64 is Ala, Asn, Pro, Ser, or Lys;

[0106] Xaa at position 65 is Val, Thr, Pro, His, Leu, Phe, or Ser;

[0107] Xaa at position 66 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

[0108] Xaa at position 67 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

[0109] Xaa at position 68 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

[0110] Xaa at position 69 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

[0111] Xaa at position 70 is Asn, Leu, Val, Trp, Pro, or Ala;

[0112] Xaa at position 71 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

[0113] Xaa at position 72 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

[0114] Xaa at position 73 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

[0115] Xaa at position 74 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

[0116] Xaa at position 75 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

[0117] Xaa at position 76 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

[0118] Xaa at position 77 is Ile, Ser, Arg, Thr, or Leu;

[0119] Xaa at position 78 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

[0120] Xaa at position 79 is Lys, Thr, Asn, Met, Arg, Ile, Gly, or Asp;

[0121] Xaa at position 80 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

[0122] Xaa at position 81 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

[0123] Xaa at position 82 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

[0124] Xaa at position 83 is Pro, Ala, Thr, Trp, Arg, or Met;

[0125] Xaa at position 84 is Cys, Glu, Gly, Arg, Met, or Val;

[0126] Xaa at position 85 is Leu, Asn, Val, or Gln;

[0127] Xaa at position 86 is Pro, Cys, Arg, Ala, or Lys;

[0128] Xaa at position 87 is Leu, Ser, Trp, or Gly;

[0129] Xaa at position 88 is Ala, Lys, Arg, Val, or Trp;

[0130] Xaa at position 89 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

[0131] Xaa at position 90 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

[0132] Xaa at position 91 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

[0133] Xaa at position 92 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

[0134] Xaa at position 93 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

[0135] Xaa at position 94 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala, or Pro;

[0136] Xaa at position 95 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile, or Tyr;

[0137] Xaa at position 96 is Pro, Lys, Tyr, Gly, Ile, or Thr;

[0138] Xaa at position 97 is Ile, Val, Lys, Ala, or Asn;

[0139] Xaa at position 98 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

[0140] Xaa at position 99 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

[0141] Xaa at position 100 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, or Pro;

[0142] Xaa at position 101 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu, or Gln;

[0143] Xaa at position 102 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

[0144] Xaa at position 103 is Asp, or Ser;

[0145] Xaa at position 104 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

[0146] Xaa at position 105 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

[0147] Xaa at position 106 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

[0148] Xaa at position 108 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala or Pro;

[0149] Xaa at position 109 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

[0150] Xaa at position 110 is Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser, or Trp;

[0151] Xaa at position 111 is Leu, Ile, Arg, Asp, or Met;

[0152] Xaa at position 112 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

[0153] Xaa at position 113 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

[0154] Xaa at position 114 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

[0155] Xaa at position 115 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

[0156] Xaa at position 116 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

[0157] Xaa at position 117 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

[0158] Xaa at position 118 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

[0159] Xaa at position 119 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

[0160] Xaa at position 120 is Asn, Ala, Pro, Leu, His, Val, or Gln;

[0161] Xaa at position 121 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

[0162] Xaa at position 122 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

[0163] Xaa at position 123 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

[0164] wherein from 1 to 14 amino acids can be deleted from the N-terminus and/or from 1 to 15 amino acids can be deleted from the C-terminus of said human interleukin-3 mutant polypeptide; and wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding amino acids of native (1-133) human interleukin-3;

[0165] R2 is a hematopoietic growth factor;

[0166] L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be immediately preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

[0167] (b) harvesting said cultured stem cells.

[0168] Additionally, the present invention encompasses methods of ex-vivo expansion of stem cells comprising the steps of (a) separating stem cells from a mixed population of cells; (b) culturing said separated stem cells with a growth medium comprising a chimera protein; (c) harvesting said cultured cells.

[0169] The present invention includes methods for treatment of a patient having a hematopoietic disorder, comprising the steps of; (a) removing stem cells from said patient or a blood donor; (b) culturing said stem cells with a growth medium comprising a chimera protein; (c) harvesting said cultured cells; and (d) transplanting said cultured cells into said patient.

[0170] The present invention also includes methods for treatment of a patient having a hematopoietic disorder, comprising the steps of; (a) removing stem cells from said patient or a blood donor; (b) separating stem cells from a mixed population of cells; (c) culturing said separated stem cells with a growth medium comprising a chimera protein; (d) harvesting said cultured cells; and (e) transplanting said cultured cells into said patient.

[0171] It is also envisioned that a patient could be given a hematopoietic growth factor, preferably a early acting factor, prior to removing stem cells for ex-vivo expansion to increase the number of early progenitors. It is also envisioned that a portion of the stem cells removed from a patient could be frozen and transplanted with the expanded stem cells to provide more early progenitors.

[0172] It is envisioned that the present invention includes methods of human gene therapy, comprising the steps of; (a) removing stem cells from a patient or blood donor; (b) culturing said stem cells with a selected growth medium comprising a chimera protein; (c) introducing DNA into said cultured cells; (d) harvesting said transduced cells; and (e) transplanting said transduced cells into said patient.

[0173] It is also envisioned that the present invention includes methods of human gene therapy, comprising the steps of; (a) removing stem cells from a patient or blood donor; (b) separating said stem cells from a mixed population of cells; (c) culturing said separated stem cells with a selected growth medium comprising a chimera protein; (d) introducing DNA into said cultured cells; (e) harvesting said transduced cells; and (f) transplanting said transduced cells into said patient.

[0174] It is also intended that the present invention includes methods of ex vivo expansion of hematopoietic cells, methods of expanding hematopoietic cells for gene therapy and methods of treating a patient using the expanded cells using the chimeric proteins of the present invention with other hematopoietic growth factors. A non-exclusive list of other appropriate hematopoietic growth factors, colony stimulating factors, cytokines, lymphokines, hematopoietic growth factors and interleukins for simultaneous or serial co-administration with the polypeptides of the present invention includes GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), c-mpl receptor agonists disclosed in PCT/US96/15938, M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, B-cell growth factor, B-cell differentiation factor and eosinophil differentiation factor, stem cell factor (SCF) also known as steel factor or c-kit ligand, multi-functional hematopoietic receptor agonists disclosed in PCT/US96/15774, or combinations thereof.

BRIEF DESCRIPTION OF THE DRAWINGS

[0175] FIG. 1 is the human IL-3 gene for E. coli expression (pMON5873), encoding the polypeptide sequence of natural (wild type) human IL-3 (SEQ ID NO: 49), plus an initiator methionine, as expressed in E. coli, with the amino acids numbered from the N-terminus of the natural hIL-3.

[0176] FIG. 2 shows the bioactivity, as measured in the methylcellulose assay, of the polypeptide chimera pMON3988.

[0177] FIG. 3 shows the bioactivity, as measured in the methylcellulose assay, of the polypeptide chimeras pMON3987 and pMON26430, pMON3995 and pMON26415.

[0178] FIG. 4 shows the bioactivity, as measured in the methylcellulose assay, of the polypeptide chimera pMON26425.

[0179] FIG. 5 shows the bioactivity, as measured in the methylcellulose assay, of the polypeptide chimeras pMON26406 and pMON26433.

[0180] FIG. 6 shows the bioactivity, as measured in the methylcellulose assay, of the polypeptide chimeras pMON26431 and pMON26427.

DETAILED DESCRIPTION OF THE INVENTION

[0181] The present invention encompasses methods of ex-vivo expansion of hematopoietic cells using a chimera protein comprising a recombinant human interleukin-3 (hIL-3) variants or mutant proteins (muteins) joined with or without a linker to a second IL-3 mutein, IL-3 or a second factor including but not limited to colony stimulating factors, cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants. This invention encompasses the ex-vivo expansion use of these mixed function hematopoietic growth factors (chimera protein) formed from covalently linked polypeptides, each of which may act through a different and specific cell receptor to initiate complementary biological activities.

[0182] Hematopoiesis requires a complex series of cellular events in which stem cells generate continuously into large populations of maturing cells in all major lineages. There are currently at least 20 known regulators with hematopoietic proliferative activity. Most of these proliferative regulators can stimulate one or another type of colony formation in vitro, the precise pattern of colony formation stimulated by each regulator is quite distinctive. No two regulators stimulate exactly the same pattern of colony formation, as evaluated by colony numbers or, more importantly, by the lineage and maturation pattern of the cells making up the developing colonies. Proliferative responses can most readily be analyzed in simplified in vitro culture systems. Three quite different parameters can be distinguished: alteration in colony size, alteration in colony numbers and cell lineage. Two or more factors may act on the progenitor cell, inducing the formation of larger number of progeny thereby increasing the colony size. Two or more factors may allow increased number of progenitor cells to proliferate either because distinct subsets of progenitors cells exist that respond exclusively to one factor or because some progenitors require stimulation by two or more factors before being able to respond. Activation of additional receptors on a cell by the use of two or more factors is likely to enhance the mitotic signal because of coalescence of initially differing signal pathways into a common final pathway reaching the nucleus (Metcalf, Nature 339:27, 1989). Other mechanisms could explain synergy. For example, if one signaling pathway is limited by an intermediate activation of an additional signaling pathway by a second factor may result in a superadditive response. In some cases, activation of one receptor type can induce a enhanced expression of other receptors (Metcalf, Blood 82(12):3515-3523 1993). Two or more factors may result in a different pattern of cell lineages then from a single factor. The use of chimera molecules may have the potential clinical advantage resulting from a proliferative response that is not possible by any single factor.

[0183] Hematopoietic and other growth factors can be grouped in to two distinct families of related receptors: (1) tyrosine kinase receptors, including those for epidermal growth factor, M-CSF (Sherr, 1990) and SCF (Yarden et al., EMBO J 6:3341, 1987): and (2) hematopoietic receptors, not containing a tyrosine kinase domain, but exhibiting obvious homology in their extracellular domain (Bazan, Proc. Natl. Acad. Sci. U.S.A. 87(18):6934-8 1990). Included in this later group are erythropoietin (EPO) (D'Andrea et al., Cell 57:277 1989), GM-CSF (Gearing et al., EMBO J 8:3667 1989), IL-3 (Kitamura et al., Cell 66:1165 1991), G-CSF (Fukunaga et al., J. Biol. Chem. 265(23):14008-15 1990), IL-4 (Harada et al., 1990), IL-5 (Takaki et al., EMBO J 9:4367 1990), IL-6 (Yamasaki et al., Science 241:825 1988), IL-7 (Goodwin et al., Cell 60(6):941-51 1990), LIF (Gearing et al., EMBO J 10:2839 1991) and IL-2 (Cosman et al., 1987). Most of the later group of receptors exists in high-affinity form as a heterodimers. After ligand binding, the specific &agr;-chains become associated with at least one other receptor chain (&bgr;-chain, &ggr;-chain). Many of these factors share a common receptor subunit. The &agr;-chains for GM-CSF, IL-3 and IL-5 share the same &bgr;-chain (Kitamura et al., Cell 66:1165 1991, Takaki et al., EMBO. J. 10(10):2833-8 1991) and receptor complexes for IL-6, LIF and IL-11 share a common &bgr;-chain (gp130) (Taga et al., Cell 58(3):573-81 1989; Gearing et al., EMBO J 10:2839 1992). The receptor complexes of IL-2, IL-4 and IL-7 share a common &ggr;-chain (Kondo et al., Science 262:1874 1993; Russell et al., Science 262:1880 1993; Noguchi et al., Science 262:1877 1993).

[0184] The ex-vivo expansion methods of the present invention use chimera proteins of the formula selected from the group consisting of

[0185] R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

[0186] where R1 is a hIL-3 variant which contains multiple amino acid substitutions and which may have portions of he hIL-3 molecule deleted as is disclosed in WO 94/12638, R2 is a hematopoietic growth factor with a different but complementary activity. By complementary activity is meant activity which enhances or changes the response to another cell modulator. The R1 polypeptide is joined either directly or through a linker segment to the R2 polypeptide. The term “directly” defines chimeras in which the polypeptides are joined without a peptide linker. Thus L represents a chemical bound or polypeptide segment to which both R1 and R2 are joined in frame, most commonly L is a linear peptide to which R1 and R2 are bound by amide bonds linking the carboxy terminus of R1 to the amino terminus of L and carboxy terminus of L to the amino terminus of R2. By “joined in frame” is meant that there is no translation termination or disruption between the reading frames of the DNA sequence encoding R1 and R2. A non-exclusive list of other growth factors, colony stimulating factors, cytokines, lymphokines, interleukins, and hematopoietic growth factors within the definition of R2, which can be joined to a hIL-3 variant of the present invention include GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL.-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, 13-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF) also known as steel factor or c-kit ligand. Additionally, this invention encompasses the use of modified R2 molecules or mutated or modified DNA sequences encoding these R2 molecules. The present invention also includes chimera molecules in which R2 is a hIL-3 variant which means an IL-3 in which has amino acid substitutions and which may have portions of the hIL-3 molecule deleted such as what is disclosed in WO 94/12638 and WO 94/12639 as well as other variants known in the art.

[0187] As used herein human interleukin-3 corresponds to the amino acid sequence (1-133) as depicted in FIG. 1 and (15-125) hIL-3 corresponds to the 15 to 125 amino acid sequence of the hIL-3 polypeptide. Naturally occurring variants of hIL-3 polypeptide amino acids are also included in the present invention (for example, the allele in which proline rather than serine is at position 8 in the hIL-3 polypeptide sequence) as are variant hIL-3 molecules which are modified post-translationally (e.g. glycosylation).

[0188] “Mutant amino acid sequence,” “mutant protein” or “mutant polypeptide” refers to a polypeptide having an amino acid sequence which varies from a native sequence or is encoded by a nucleotide sequence intentionally made variant from a native sequence. “Mutant protein,” “variant protein” or “mutein” means a protein comprising a mutant amino acid sequence and includes polypeptides which differ from the amino acid sequence of native hIL-3 due to amino acid deletions, substitutions, or both. “Native sequence” refers to an amino acid or nucleic acid sequence which is identical to a wild-type or native form of a gene or protein.

[0189] Human IL-3 can be characterized by its ability to stimulate colony formation by human hematopoietic progenitor cells. The colonies formed include erythroid, granulocyte, megakaryocyte, granulocytic macrophages and mixtures thereof. Human IL-3 has demonstrated an ability to restore bone marrow function and peripheral blood cell populations to therapeutically beneficial levels in studies performed initially in primates and subsequently in humans (Gillio, A. P., et al. J. Clin. Invest. 85: 1560 (1990); Ganser, A., et al. Blood 76: 666 (1990); Falk, S., et al. Hematopathology 95: 355 (1991). Additional activities of hIL-3 include the ability to stimulate leukocyte migration and chemotaxis; the ability to prime human leukocytes to produce high levels of inflammatory mediators like leukotrienes and histamine; the ability to induce cell surface expression of molecules needed for leukocyte adhesion; and the ability to trigger dermal inflammatory responses and fever. Other IL-3-like properties are the interaction with early multipotential stem cells, the sustaining of the growth of pluripotent precursor cells, the ability to stimulate chronic myelogenous leukemia (CML) cell proliferation, the stimulation of proliferation of mast cells, the ability to support the growth of various factor-dependent cell lines, and the ability to trigger immature bone marrow cell progenitors. Other biological properties of IL-3 have been disclosed in the art. Many or all of these biological activities of hIL-3 involve signal transduction and high affinity receptor binding.

[0190] Biological activity of hIL-3 and hIL-3 chimera proteins of the present invention is determined by DNA synthesis by human acute myelogenous leukemia cells (AML). The factor-dependent cell line AML 193 was adapted for use in testing biological activity. The biological activity of hIL-3 and hIL-3 chimera proteins of the present invention is also determined by counting the colony forming units in a bone marrow assay.

[0191] Other in vitro cell based assays may also be useful to determine the activity of the chimera molecules depending on the hematopoietic growth factors that comprise the chimera. The following are examples of other useful assays.

[0192] TF-1 proliferation assay: The TF-1 cell line was derived from bone marrow of a patient with erythroleukemia (Kitamura et al., J. Cell Physiol. 140:323-334, 1989). TF-1 cells respond to IL-3, GM-CSF, EPO and IL-5.

[0193] 32D proliferation assay: 32D is a murine IL-3 dependent cell line which does not respond to human IL-3 but does respond to human G-CSF which is not species restricted. T1165 proliferation assay: T1165 cells are a IL-6 dependent murine cell line (Nordan et al., Science 233:566, 1986) which respond to IL-6 and IL-11.

[0194] Human Plasma Clot meg-CSF Assay: Used to assay megakaryocyte colony formation activity (Mazur et al., Blood 57:277-286 1981).

[0195] Compounds of this invention are preferably made by genetic engineering techniques now standard in the art U.S. Pat. No. 4,935,233 and Sambrook et al., “Molecular Cloning. A Laboratory Manual”, Cold Spring Harbor Laboratory, 1989. One method of creating the preferred hIL-3 (15-125) mutant genes is cassette mutagenesis (Wells, et al. Gene, 34:315-323, 1985) in which a portion of the coding sequence of hIL-3 in a plasmid is replaced with synthetic oligonucleotides that encode the desired amino acid substitutions in a portion of the gene between two restriction sites. In a similar manner amino acid substitutions could be made in the full-length hIL-3 gene, or genes encoding variants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus and/or from 1 to 15 amino acids have been deleted from the C-terminus. When properly assembled these oligonucleotides would encode hIL-3 variants with the desired amino acid substitutions and/or deletions from the N-terminus and/or C-terminus. These and other mutations could be created by those skilled in the art by other mutagenesis methods including; oligonucleotide-directed mutagenesis (Zoller and Smith Nucleic Acid Research, 10:6487-6500, 1982; Zoller and Smith Methods in Enzymology, 100:468-500, 1983; Zoller and Smith DNA, 3: 479, 1984 Smith M. Ann. Rev. Genet., 19:423-462, 1985; Kunkel Proc. Natl. Acad. Sci. USA, 82: 488-492, 1985, Taylor, et al. Nucl. Acids Res., 13:8764-8785 (1985), Deng and Nickoloff, Anal-Biochem 200:81-88, 1992) or polymerase chain reaction (PCR) techniques (Saiki, Science 230:1350-1354, 1985).

[0196] Additional details about recombinant techniques for construction of DNA sequences that encode the chimera proteins, plasmid DNA vectors for use in the expression of these novel chimera molecules, methods for producing the chimera molecules in bacterial cells, mammalian cells, or insect cells and the in-vitro and in-vivo activity of the chimera proteins can be found in WO 95/21254. It is understood that the chimera molecules of the present invention, used for the ex-vivo expansion of hematopoietic cells, can be made by other methods known to those skilled in the art.

[0197] Hematopoietic cells that have been expanded ex-vivo using the chimera molecules of the present invention may be useful in the treatment of diseases characterized by a decreased levels of either myeloid, erythroid, lymphoid, or megakaryocyte cells of the hematopoietic system or combinations thereof. In addition, they may be used to activate mature myeloid and/or lymphoid cells. Among conditions susceptible to treatment with hematopoietic cells that have been expanded ex-vivo using the chimera proteins of the present invention is leukopenia, a reduction in the number of circulating leukocytes (white cells) in the peripheral blood. Leukopenia may be induced by exposure to certain viruses or to radiation. It is often a side effect of various forms of cancer therapy, e.g., exposure to chemotherapeutic drugs, radiation and of infection or hemorrhage. Therapeutic treatment of leukopenia with these chimera molecules of the present invention may avoid undesirable side effects caused by treatment with presently available drugs.

[0198] Hematopoietic cells that have been expanded ex-vivo using the chimera molecules of the present invention may be useful in the treatment of neutropenia and, for example, in the treatment of such conditions as aplastic anemia, cyclic neutropenia, idiopathic neutropenia, Chediak-Higashi syndrome, systemic lupus erythematosus (SLE), leukemia, myelodysplastic syndrome and myelofibrosis.

[0199] Hematopoietic cells that have been expanded ex-vivo using the chimera molecule of the present invention may be useful in the treatment or prevention of thrombocytopenia. Currently the only therapy for thrombocytopenia is platelet transfusions which are costly and carry the significant risks of infection (HIV, HBV) and alloimunization. Treatment involving the transplantation of the hematopoietic cells that have been expanded ex-vivo using chimera proteins of the present invention into a patient, may alleviate or diminish the need for platelet transfusions. Severe thrombocytopenia may result from genetic defects such as Fanconi's Anemia, Wiscott-Aldrich, or May-Hegglin syndromes. Acquired thrombocytopenia may result from auto- or allo-antibodies as in Immune Thrombocytopenia Purpura, Systemic Lupus Erythromatosis, hemolytic anemia, or fetal maternal incompatibility. In addition, splenomegaly, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, infection or prosthetic heart valves may result in thrombocytopenia. Severe thrombocytopenia may also result from chemotherapy and/or radiation therapy or cancer. Thrombocytopenia may also result from marrow invasion by carcinoma, lymphoma, leukemia or fibrosis.

[0200] One aspect of the present invention provides a novel hematopoietic factors for selective ex-vivo expansion of stem cells. The term “stem cell” refers to the totipiotent hematopoietic stem cells as well as early precursors and progenitor cells which can be isolated from bone marrow, spleen or peripheral blood. The term “expanding” refers to the differentiation and proliferation of the cells. The present invention provides a method for selective ex-vivo expansion of stem cells, comprising the steps of; (a) separating stem cells from a mixed population of cells, (b) culturing said separated stem cells with a selected media which contains a chimera protein(s) and (c) harvesting said cultured stems cells.

[0201] Stem cells as well as committed progenitor cells destined to become neutrophils, erythrocytes, platelets. etc., may be distinguished from most other cells by the presence or absence of particular progenitor marker antigens, such as CD34, that are present on the surface of these cells and/or by morphological characteristics. The phenotype for a highly enriched human stem cell fraction is reported as CD34+, Thy-1+ and lin−, but it is to be understood that the present invention is not limited to the expansion of this stem cell population. The CD34+ enriched human stem cell fraction can be separated by a number of reported methods, including affinity columns or beads, magnetic beads or flow cytometry using antibodies directed to surface antigens such as the CD34+. Further, physical separation methods such as counterflow elutriation may be used to enrich hematopoietic progenitors. The CD34+ progenitors are heterogeneous, and may be divided into several subpopulations characterized by the presence or absence of coexpression of different lineage associated cell surface associated molecules. The most immature progenitor cells do not express any known lineage-associated markers, such as HLA-DR or CD38, but they may express CD90(thy-1). Other surface antigens such as CD33, CD38, CD41, CD71, HLA-DR or c-kit can also be used to selectively isolate hematopoietic progenitors. The separated cells can be incubated in selected medium in a culture flask, sterile bag or in hollow fibers. Various hematopoietic growth factors may be utilized in order to selectively expand cells. Representative factors that have been utilized for ex-vivo expansion of bone marrow include, c-kit ligand, IL-3, G--CSF, GM-CSF, IL-1, IL-6, IL-11, flt-3 ligand or combinations thereof. The proliferation of the stem cells can be monitored by enumerating the number of stem cells and other cells, by standard techniques (e.g. hemacytometer, CFU, LTCIC) or by flow cytometry prior and subsequent to incubation.

[0202] Several methods for ex-vivo expansion of stem cells have been reported utilizing a number of selection methods and expansion using various hematopoietic growth factors including c-kit ligand (Brandt et al., Blood 83:1507-1514 (1994), McKenna et al., Blood 86:3413-3420 (1995), IL-3 (Brandt et al., Blood 83:1507-1514 (1994), Sato et al., Blood 82:3600-3609 (1993), G-CSF (Sato et al., Blood 82:3600-3609 (1993), GM-CSF (Sato et al., Blood 82:3600-3609 (1993), IL-1 (Muench et al., Blood 81:3463-3473 (1993), IL-6 (Sato et al., Blood 82:3600-3609 (1993), IL-11 (Lemoli et al., Exp. Hem. 21:1668-1672 (1993), Sato et al., Blood 82:3600-3609 (1993), flt-3 ligand (McKenna et al., Blood 86:3413-3420 (1995) and/or combinations thereof (Brandt et al., Blood 83:1507-1514 (1994), Haylock et al., Blood 80:1405-1412 (1992), Koller et al., Biotechnology 11:358-363 (1993), (Lemoli et al., Exp. Hem. 21:1668-1672 (1993), McKenna et al., Blood 86:3413-3420 (1995), Muench et al., Blood 81:3463-3473 (1993), Patchen et al., Biotherapy 7:13-26 (1994), Sato et al., Blood 82:3600-3609 (1993), Smith et al., Exp. Hem. 21:870-877 (1993), Steen et al., Stem Cells 12:214-224 (1994), Tsujino et al., Exp. Hem. 21:1379-1386 (1993). Among the individual hematopoietic growth factors, hIL-3 has been shown to be one of the most potent in expanding peripheral blood CD34+ cells (Sato et al., Blood 82:3600-3609 (1993), Kobayashi et al., Blood 73:1836-1841 (1989). However, no single factor has been shown to be as effective as the combination of multiple factors. The present invention provides methods for ex vivo expansion that utilize molecules that are more effective than IL-3 alone.

[0203] Another projected clinical use of growth factors has been in the in vitro activation of hematopoietic progenitors and stem cells for gene therapy. Due to the long life-span of hematopoietic progenitor cells and the distribution of their daughter cells throughout the entire body, hematopoietic progenitor cells are good candidates for ex vivo gene transfection. In order to have the gene of interest incorporated into the genome of the hematopoietic progenitor or stem cell one needs to stimulate cell division and DNA replication. Hematopoietic stem cells cycle at a very low frequency which means that growth factors may be useful to promote gene transduction and thereby enhance the clinical prospects for gene therapy. Potential applications of gene therapy (review Crystal, Science 270:404-410 (1995) include; 1) the treatment of many congenital metabolic disorders and immunodifiencies (Kay and Woo, Trends Genet. 10:253-257 (1994), 2) neurological disorders (Freedmann, Trends Genet. 10:210-214 (1994), 3) cancer (Culver and Blaese, Trends Genet. 10:174-178 (1994) and 4) infectious diseases (Gilboa and Smith, Trends Genet. 10:139-144 (1994). Due to the long life-span of hematopoietic progenitor cells and the distribution of their daughter cells throughout the entire body, hematopoietic progenitor cells are good candidates for ex vivo gene transfection include the treatment of many congenital metabolic disorders and immunodifiencies (Kay and Woo, Trends Genet. 10:253-257 (1994) neurological disorders (Freedmann, Trends Genet. 10:210-214 (1994), cancer (Culver and Blaese, Trends Genet. 10:174-178 (1994) and infectious diseases (Gilboa and Smith, Trends Genet. 10:139-144 (1994).

[0204] There are a variety of methods, known to those with skill in the art, for introducing genetic material into a host cell. A number of vectors, both viral and non-viral have been developed for transferring therapeutic genes into primary cells. Viral based vectors include; 1) replication-deficient recombinant retrovirus (Boris-Lawrie and Temin, Curr. Opin. Genet. Dev. 3:102-109 (1993), Boris-Lawrie and Temin, Annal. New York Acad. Sci. 716:59-71 (1994), Miller, Current Top. Microbiol. Immunol. 158:1-24 (1992) and replication-deficient recombinant adenovirus (Berkner, BioTechniques 6:616-629 (1988), Berkner, Current Top. Microbiol. Immunol. 158:39-66 (1992), Brody and Crystal, Annal. New York Acad. Sci. 716:90-103 (1994). Non-viral based vectors include protein/DNA complexes (Cristiano et al., PNAS USA. 90:2122-2126 (1993), Curiel et al., PNAS USA 88:8850-8854 (1991), Curiel, Annal. New York Acad. Sci. 716:36-58 (1994), electroporation and liposome mediated delivery such as cationic liposomes (Farhood et al., Annal. New York Acad. Sci. 716:23-35 (1994).

[0205] The present invention provides an improvement to the existing methods of expanding hematopoietic cells, which new genetic material has been introduced, in that it provides methods utilizing chimera proteins that have improved biological activity, including an activity not seen by any single colony stimulation factor and/or physical properties.

[0206] Many drugs may cause bone marrow suppression or hematopoietic deficiencies. Examples of such drugs are AZT, DDI, alkylating agents and anti-metabolites used in chemotherapy, antibiotics such as chloramphenicol, penicillin, gancyclovir, daunomycin and sulfa drugs, phenothiazones, tranquilizers such as meprobamate, analgesics such as aminopyrine and dipyrone, anti convulsants such as phenytoin or carbamazepine, antithyroids such as propylthiouracil and methimazole and diuretics. Hematopoietic cells that have been expanded ex-vivo using the chimera molecules of the present invention may be useful in preventing or treating the bone marrow suppression or hematopoietic deficiencies which often occur in patients treated with these drugs.

[0207] Hematopoietic deficiencies may also occur as a result of viral, microbial or parasitic infections and as a result of treatment for renal disease or renal failure, e.g., dialysis. Hematopoietic cells that have been expanded ex-vivo using the chimera molecules of the present invention may be useful in treating such hematopoietic deficiency.

[0208] Various immunodeficiencies e.g., in T and/or B lymphocytes, or immune disorders, e.g., rheumatoid arthritis, may also be beneficially affected by treatment with hematopoietic cells that have been expanded ex-vivo using the chimera molecules of the present invention. Immunodeficiencies may be the result of viral infections e.g. HTLVI, HTLVII, HTLVIII, severe exposure to radiation, cancer therapy or the result of other medical treatment. The chimera molecules of the present invention may also be employed, alone or in combination with other hematopoietic growth factors, in the treatment of other blood cell deficiencies, including thrombocytopenia (platelet deficiency), or anemia. Other uses for these novel polypeptides are in the treatment of patients recovering from bone marrow transplants.

[0209] As indicated above, the therapeutic method may also include co-administration with other human factors. A non-exclusive list of other appropriate hematopoietic growth factors, colony stimulating factors, cytokines, lymphokines, hematopoietic growth factors and interleukins for simultaneous or serial co-administration with the polypeptides of the present invention includes GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), c-mpl receptor agonists disclosed in PCT/US96/15938, M--CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, B-cell growth factor, 13-cell differentiation factor and eosinophil differentiation factor, stem cell factor (SCF) also known as steel factor or c-kit ligand, multi-functional hematopoietic receptor agonists disclosed in PCT/US96/15774, or combinations thereof.

[0210] The treatment of hematopoietic deficiency may include removing hematopoietic cell from a patient, culturing the cell in a medium containing the chimera molecules to differentiate and proliferate the cells and returning the cultured cells to the patient following a medical treatment. In addition, hematopoietic cell can be removed from a blood donor, cultured and given to a patient suffering from a hematopoietic disorder.

[0211] The present invention is directed to methods of ex-vivo expansion of hematopoietic cells by culturing the cells with a chimeric proteins(s) of the formula:

[0212] R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

[0213] wherein R1 is a human interleukin-3 mutant polypeptide of the Formula: 1 Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Thr Ser Trp Val Asn (SEQ ID NO:1)  1               5                   10                  15 Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa                  20                  25                  30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa                  35                  40                  45 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa                  50                  55                  60 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa                  80                  85                  90 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa                  95                 100                 105 Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa                 110                 115                 120 Xaa Xaa Xaa Gln Gln Thr Thr Leu Ser Leu Ala Ile Phe                 125                 130

[0214] wherein

[0215] Xaa at position 17 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

[0216] Xaa at position 18 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

[0217] Xaa at position 19 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

[0218] Xaa at position 20 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

[0219] Xaa at position 21 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

[0220] Xaa at position 22 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val or Gly;

[0221] Xaa at position 23 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

[0222] Xaa at position 24 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

[0223] Xaa at position 25 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

[0224] Xaa at position 26 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

[0225] Xaa at position 27 is Leu, Gly, Arg, Thr, Ser, or Ala;

[0226] Xaa at position 28 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

[0227] Xaa at position 29 is Gln, Asn, Leu, Pro, Arg, or Val;

[0228] Xaa at position 30 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

[0229] Xaa at position 31 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

[0230] Xaa at position 32 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

[0231] Xaa at position 33 is Pro, Leu, Gln, Ala, Thr, or Glu;

[0232] Xaa at position 34 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

[0233] Xaa at position 35 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

[0234] Xaa at position 36 is Asp, Leu, or Val;

[0235] Xaa at position 37 is Phe, Ser, Pro, Trp, or Ile;

[0236] Xaa at position 38 is Asn, or Ala;

[0237] Xaa at position 40 is Leu, Trp, or Arg;

[0238] Xaa at position 41 is Asn, Cys, Arg, ]Leu, His, Met, or Pro;

[0239] Xaa at position 42 is Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met or Ala;

[0240] Xaa at position 43 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

[0241] Xaa at position 44 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

[0242] Xaa at position 45 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu or His;

[0243] Xaa at position 46 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

[0244] Xaa at position 47 is Ile, Gly, Val, Ser, Arg, Pro, or His;

[0245] Xaa at position 48 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

[0246] Xaa at position 49 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

[0247] Xaa at position 50 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

[0248] Xaa at position 51 is Asn, Arg, Met, Pro, Ser, Thr, or His;

[0249] Xaa at position 52 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

[0250] Xaa at position 53 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

[0251] Xaa at position 54 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

[0252] Xaa at position 55 is Arg, Thr, Val, Ser, Leu, or Gly;

[0253] Xaa at position 56 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

[0254] Xaa at position 57 is Asn or Gly;

[0255] Xaa at position 58 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

[0256] Xaa at position 59 is Glu, Tyr, His, Leu, Pro, or Arg;

[0257] Xaa at position 60 is Ala, Ser, Pro, Tyr, Asn, or Thr;

[0258] Xaa at position 61 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

[0259] Xaa at position 62 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

[0260] Xaa at position 63 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

[0261] Xaa at position 64 is Ala, Asn, Pro, Ser, or Lys;

[0262] Xaa at position 65 is Val, Thr, Pro, His, Leu, Phe, or Ser;

[0263] Xaa at position 66 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

[0264] Xaa at position 67 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

[0265] Xaa at position 68 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

[0266] Xaa at position 69 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

[0267] Xaa at position 70 is Asn, Leu, Val, Trp, Pro, or Ala;

[0268] Xaa at position 71 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

[0269] Xaa at position 72 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

[0270] Xaa at position 73 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

[0271] Xaa at position 74 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

[0272] Xaa at position 75 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

[0273] Xaa at position 76 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

[0274] Xaa at position 77 is Ile, Ser, Arg, Thr, or Leu;

[0275] Xaa at position 78 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

[0276] Xaa at position 79 is Lys, Thr, Asn, Met, Arg, Ile, Gly, or Asp;

[0277] Xaa at position 80 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

[0278] Xaa at position 81 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

[0279] Xaa at position 82 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

[0280] Xaa at position 83 is Pro, Ala, Thr, Trp, Arg, or Met;

[0281] Xaa at position 84 is Cys, Glu, Gly, Arg, Met, or Val;

[0282] Xaa at position 85 is Leu, Asn, Val, or Gln;

[0283] Xaa at position 86 is Pro, Cys, Arg, Ala, or Lys;

[0284] Xaa at position 87 is Leu, Ser, Trp, or Gly;

[0285] Xaa at position 88 is Ala, Lys, Arg, Val, or Trp;

[0286] Xaa at position 89 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

[0287] Xaa at position 90 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

[0288] Xaa at position 91 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

[0289] Xaa at position 92 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

[0290] Xaa at position 93 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

[0291] Xaa at position 94 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala, or Pro;

[0292] Xaa at position 95 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile, or Tyr;

[0293] Xaa at position 96 is Pro, Lys, Tyr, Gly, Ile, or Thr;

[0294] Xaa at position 97 is Ile, Val, Lys, Ala, or Asn;

[0295] Xaa at position 98 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

[0296] Xaa at position 99 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

[0297] Xaa at position 100 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, or Pro;

[0298] Xaa at position 101 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu, or Gln;

[0299] Xaa at position 102 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

[0300] Xaa at position 103 is Asp, or Ser;

[0301] Xaa at position 104 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

[0302] Xaa at position 105 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

[0303] Xaa at position 106 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

[0304] Xaa at position 108 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala or Pro;

[0305] Xaa at position 109 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

[0306] Xaa at position 110 is Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser, or Trp;

[0307] Xaa at position 111 is Leu, Ile, Arg, Asp, or Met;

[0308] Xaa at position 112 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

[0309] Xaa at position 113 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

[0310] Xaa at position 114 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

[0311] Xaa at position 115 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

[0312] Xaa at position 116 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

[0313] Xaa at position 117 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

[0314] Xaa at position 118 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

[0315] Xaa at position 119 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

[0316] Xaa at position 120 is Asn, Ala, Pro, Leu, His, Val, or Gln;

[0317] Xaa at position 121 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

[0318] Xaa at position 122 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

[0319] Xaa at position 123 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

[0320] wherein from 1 to 14 amino acids can be deleted from the N-terminus and/or from 1 to 15 amino acids can be deleted from the C-terminus; and wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding amino acids of native (1-133) human interleukin-3;

[0321] R2 is a hematopoietic growth factor;

[0322] L is a linker capable of linking R1 and R2;and said chimera protein can additionally be immediately preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−2).

[0323] In a preferred embodiment, R2 is a hematopoietic growth factor selected from the group consisting of GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, I-L-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

[0324] The dosage regimen involved in ex-vivo expansion of hematopoietic cells and methods for treating the above-described conditions will be determined by the attending physician considering various factors which modify the action of drugs, e.g. the condition, body weight, sex and diet of the patient, the severity of any infection, time of administration and other clinical factors. Generally, a dosage regimen may be in the range of 1 ng to 100 ng of non-glycosylated IL-3 chimeric protein per mL of culture medium. This dosage regimen is referenced to a standard level of biological activity which recognizes that native IL-3 generally possesses an EC50 at or about 10 picoMolar to 100 picoMolar in the AML proliferation assay described herein. Therefore, dosages would be adjusted relative to the activity of a given chimera protein vs. the activity of native (reference) IL-3 and it would not be unreasonable to note that dosage regimens may include doses as low as 0.1 ng and as high as 1 milligram per mL of culture medium. In addition, there may exist specific circumstances where dosages of chimera protein would be adjusted higher or lower. When administered with the chimera proteins of the present invention, other hematopoietic growth factors are used in the range of 1 ng to 100 ng per mL of culture medium. The other hematopoietic growth factors could be used as low as 1 pg/mL and as high as 1 mg/mL depending on the chimeria protein used, the various combination of hematopoietic growth factors used and the nature of the expanded hematopoietic cell population that is desired. Other factors that could effect the dosage of the chimera proteins and other hematopoietic growth factors include; co-administration with chemotherapeutic drugs and/or radiation; the use of glycosylated proteins; and various patient-related issues mentioned earlier in this section.

[0325] The following examples will illustrate the invention in greater detail although it will be understood that the invention is not limited to these specific examples.

EXAMPLE 1

[0326] Determination of the In Vitro Activity of Chimera Proteins

[0327] The protein concentration of the chimera protein can be determined using a sandwich ELISA based on an affinity purified polyclonal antibody. Alternatively the protein concentration can be determined by amino acid composition. The bioactivity of the chimera molecule can be determined in a number of in vitro assays compared with native IL-3, the IL-3 variant or G-CSF alone or together. One such assay is the AML-193 cell proliferation assay. AML-193 cells respond to IL-3 and G-CSF which allows for the combined bioactivity of the IL-3 variant/G-CSF chimera to be determined. In addition other factor dependent cell lines, such as M-NFS-60 (ATCC. CRL 1838) or 32D which are murine IL-3 dependent cell line, may be used. The activity of IL-3 is species specific whereas G-CSF is not, therefor the bioactivity of the G-CSF component of the IL-3 variant/G-CSF chimera can be determined independently. The methylcellulose assay can be used to determine the effect of the IL-3 variant/G-CSF chimera protein on the expansion of the hematopoietic progenitor cells and the pattern of the different types of hematopoietic colonies in vitro. The methylcellulose assay can provide an estimate of precursor frequency since one measures the frequency of progenitors per 100,000 input cells. Long term, stromal dependent cultures have been used to delineate primitive hematopoietic progenitors and stem cells. This assay can be used to determine whether the chimera molecule stimulates the expansion of very primitive progenitors and/or stem cells. In addition, limiting dilution cultures can be performed which will indicate the frequency of primitive progenitors stimulated by the chimera molecule.

[0328] Determination of Bioactivity of Chimera Molecules in AML Proliferation Assay

[0329] The AML assay is useful for determining the activity of chimera molecules that respond to hIL-3, G-CSF and

[0330] The factor-dependent cell line AML 193 was obtained from the American Type Culture Collection (ATCC, Rockville, Md.). This cell line, established from a patient with acute myelogenous leukemia, is a growth factor dependent cell line which displayed enhanced growth in GM-CSF supplemented medium (Lange, B., et al., Blood 70:192, 1987; Valtieri, M., et al., J. Immunol. 138:4042, 1987). The ability of AML 193 cells to proliferate in the presence of human IL-3 has also been documented. (Santoli, D., et al., J. Immunology 139:348, 1987). A cell line variant was used, AML 193 1.3, which was adapted for long term growth in IL-3 by washing out the growth factors and starving the cytokine dependent AML 193 cells for growth factors for 24 hours. The cells are then replated at 1×105 cells/well in a 24 well plate in media containing 100 U/mL IL-3. It took approximately 2 months for the cells to grow rapidly in IL-3. These cells are maintained as AML 193 1.3 thereafter by supplementing tissue culture medium (see below) with human IL-3.

[0331] AML 193 1.3 cells are washed 6 times in cold Hanks balanced salt solution (HBSS, Gibco, Grand Island, N.Y.) by centrifuging cell suspensions at 250× g for 10 minutes followed by decantation of the supernatant. Pelleted cells are resuspended in HBSS and the procedure is repeated until six wash cycles are completed. Cells washed six times by this procedure are resuspended in tissue culture medium at a density ranging from 2×105 to 5×105 viable cells/mL. This medium is prepared by supplementing Iscove's modified Dulbecco's Medium (IMDM, Hazelton, Lenexa, Kans.) with albumin, transferrin, lipids and 2-mercaptoethanol. Bovine albumin (Boehringer-Mannheim, Indianapolis, Ind.) is added at 500 &mgr;g/mL; human transferrin (Boehringer-Mannheim, Indianapolis, Ind.) is added at 100 &mgr;g/mL; soybean lipid (Boehringer-Mannheim, Indianapolis, Ind.) is added at 50 &mgr;g/mL; and 2-mercaptoethanol (Sigma, St. Louis, Mo.) is added at 5×10−5 M.

[0332] Serial dilutions of human interleukin-3 or chimera protein (hIL-3 mutein) are made in triplicate series in tissue culture medium supplemented as stated above in 96 well Costar 3596 tissue culture plates. Each well contained 50 &mgr;l of medium containing interleukin-3 or chimera protein once serial dilutions are completed. Control wells contained tissue culture medium alone (negative control). AML 193 1.3 cell suspensions prepared as above are added to each well by pipetting 50 &mgr;l (2.5×104 cells) into each well. Tissue culture plates are incubated at 37° C. with 5% CO2 in humidified air for 3 days. On day 3, 0.5 &mgr;Ci 3H-thymidine (2 Ci/mM, New England Nuclear, Boston, Mass.) is added in 50 &mgr;l of tissue culture medium. Cultures are incubated at 37° C. with 5% CO2 in humidified air for 18-24 hours. Cellular DNA is harvested onto glass filter mats (Pharmacia LKB, Gaithersburg, Md.) using a TOMTEC cell harvester (TOMTEC, Orange, Conn.) which utilized a water wash cycle followed by a 70% ethanol wash cycle. Filter mats are allowed to air dry and then placed into sample bags to which scintillation fluid (Scintiverse II, Fisher Scientific, St. Louis, Mo. or BetaPlate Scintillation Fluid, Pharmacia LKB, Gaithersburg, Md.) is added. Beta emissions of samples from individual tissue culture wells are counted in a LKB Betaplate model 1205 scintillation counter (Pharmacia LKB, Gaithersburg, Md.) and data is expressed as counts per minute of 3H-thymidine incorporated into cells from each tissue culture well. Activity of each human interleukin-3 preparation or chimera protein preparation is quantitated by measuring cell proliferation (3H-thymidine incorporation) induced by graded concentrations of interleukin-3 or chimera protein. Typically, concentration ranges from 0.05 pM-105 pM are quantitated in these assays. Activity is determined by measuring the dose of interleukin-3 or chimera molecule which provides 50% of maximal proliferation (EC50=0.5×(maximum average counts per minute of 3H-thymidine incorporated per well among triplicate cultures of all concentrations of interleukin-3 tested−background proliferation measured by 3H-thymidine incorporation observed in triplicate cultures lacking interleukin-3). This EC50 value is also equivalent to 1 unit of bioactivity. Every assay is performed with native interleukin-3 as a reference standard so that relative activity levels could be assigned.

[0333] Typically, the protein chimeras were tested in a concentration range of 2000 pM to 0.06 pM titrated in serial 2 fold dilutions. Biological activity of the chimera molecules was compared to the following standards as described below.

[0334] Protein chimeras comprised in part of G-CSF, pMON3987, pMON3995, pMON3997, pMON26406, pMON26433, pMON26415, pMON26416, and pMON26430, were compared to the dose response curve of equal molar concentrations of hG-CSF and pMON13288 or pMON13416.

[0335] Protein chimeras comprised in part of GM-CSF, pMON3989 and pMON3998 were compared to the dose response curve of equal molar concentrations of hGM-CSF and pMON13288. Protein chimeras comprised of dimers of hIL-3 variants, pMON3988, pMON26425, pMON26427, pMON26420, pMON26429 and pMON26431 were compared to the dose response curve of pMON13288 or pMON13416.

[0336] Activity for each sample was determined by the concentration which gave 50% of the maximal response by fitting a four-parameter logistic model to the data. It was observed that the upper plateau (maximal response) for the sample and the standard with which it was compared did not differ. Therefore relative potency calculation for each sample was determined from EC50 estimations for the sample and the standard as indicated above. Relative potency (EC50 of standard divided by EC50 of sample) reported in Table 3 is the mean of at least two independent assays unless indicated.

[0337] AML 193.1.3 cells proliferate in response to hIL-3, hGM-CSF and hG-CSF. 2 TABLE 3 AML cell proliferation assay AML 193.1.3 Bioactivity (relative pMON R1 R2 potency) pMON3987 13288 G-CSF 0.35 ± 0.11 pMON3988 13288 13288 0.64 ± 0.13 pMON3989 13288 GM-CSF  0.6 ± 0.09 pMON3995 G-CSF 13288 0.41 ± 0.44 pMON3997 13288 G-CSF 0.26 (n = 1) pMON3998 13288 GM-CSF 0.21 (n = 1) pMON26406 13288 G-CSF 0.37 ± 0.30 pMON26433 G-CSF 13288 0.79 ± 0.35 pMON26415 13288 G-CSF Ser17 0.46 ± 0.08 pMON26416 G-CSF 13416 0.43 ± 0.02 pMON26425 13288 13288 1.32 ± 0.41 pMON26427 13288 13288 1.41 ± 0.91 pMON26420 13416 13416 2.09 ± 0.52 pMON26430 13288 G-CSF 1.04 ± 0.69 pMON26429 13288 13288 1.88 ± 0.09 pMON26431 13288 13288 0.66 ± 0.26

EXAMPLE 2

[0338] Determination of Bioactivity of Chimera Molecules in Methylcellulose Assay

[0339] This assays the ability of hematopoietic growth factors to stimulate normal bone marrow cells to produce different types of hematopoietic colonies in vitro (Bradley et al., Aust. Exp. Biol. Med. Sci. 44:287-300 1966; Pluznik et al., J Cell Comp Physiol 66:319-324 1965).

[0340] Methods

[0341] Approximately 30 mL of fresh, normal, healthy bone marrow aspirate are obtained from individuals. Under sterile conditions samples are diluted 1:5 with a 1× PBS (#14040.059 Life Technologies, Gaithersburg, Md.) solution in a 50 mL conical tube (#25339-50 Corning, Corning Md.). Ficoll (Histopaque 1077 Sigma H-8889) is layered under the diluted sample and centrifuged, 300× g for 30 min. The mononuclear cell band is removed and washed two times in 1× PBS and once with 1% BSA PBS (CellPro Co., Bothel, Wash.). Mononuclear cells are counted and CD34+ cells are selected using the Ceprate LC (CD34) Kit (CellPro Co., Bothel, Wash.) column. This fractionation is performed since all stem and progenitor cells within the bone marrow display CD34 surface antigen.

[0342] Cultures are set up in triplicate with a final volume of 1.0 mL in a 35×10 mm petri dish (Nunc#174926). Culture medium is purchased from Terry Fox Labs. (HCC-4230 medium (Terry Fox Labs, Vancouver, B.C., Canada) and erythropoietin (Amgen, Thousands Oaks, Calif.) is added to the culture media. 3,000-10,000 CD34+ cells are added per dish. Native IL-3 and chimera molecules are added to give final concentrations ranging from 0.001 nM 10 nM. Native IL-3 and chimera molecules are supplied in house. G-CSF (Neupogen) is from Amgen. Cultures are resuspended using a 3 cc syringe and 1.0 mL is dispensed per dish. Control (baseline response) cultures received no hematopoietic growth factors. Positive control cultures received conditioned media (PHA stimulated human cells; Terry Fox Lab. H2400). Cultures are incubated at 37° C., 5% CO2 in humidified air.

[0343] Hematopoietic colonies which are defined as greater than 50 cells are counted on the day of peak response (days 10-11) using a Nikon inverted phase microscope with a 40× objective combination. Groups of cells containing fewer than 50 cells are referred to as clusters. Alternatively colonies can be identified by spreading the colonies on a slide and stained or they can be picked, resuspended and spun onto cytospin slides for staining.

EXAMPLE 3

[0344] Determination of Bioactivity of Chimera Molecules in Human Cord Blood Hematopoietic Growth Factor Assay

[0345] Bone marrow cells are traditionally used for in vitro assays of hematopoietic growth factor activity. However, human bone marrow is not always available, and there is considerable variability between donors. Umbilical cord blood is comparable to bone marrow as a source of hematopoietic stem cells and progenitors (Broxmeyer et al., Proc. Natl. Acad. Sci. USA, 89:4109-4113 1992; Mayani et al., Blood 81:3252-3258 1993). In contrast to bone marrow, cord blood is more readily available on a regular basis. There is also a potential to reduce assay variability by pooling cells obtained fresh from several donors, or to create a bank of cryopreserved cells for this purpose. By modifying the culture conditions, and/or analyzing for lineage specific markers, it should be possible to assay specifically for granulocyte/macrophage colonies (CFU-GM), for megakaryocyte CSF activity, or for high proliferative potential colony forming cell (HPP-CFC) activity.

[0346] Methods

[0347] Mononuclear cells (MNC) are isolated from cord blood within 24 hr. of collection, using a standard density gradient (1.077 g/mL Histopaque). Cord blood MNC have been further enriched for stem cells and progenitors by several procedures, including immunomagnetic selection for CD14−, CD34+ cells; panning for SBA−, CD34+ fraction using coated flasks from Applied Immune Science (Santa Clara, Calif.); and CD34+ selection using a CellPro (Bothell, Wash.) avidin column. Either freshly isolated or cryopreserved CD34+ cell enriched fractions are used for the assay. Duplicate cultures for each serial dilution of sample (concentration range from 1 pM to 1204 pM) are prepared with 1×104 cells in 1 ml of 0.9% methylcellulose containing medium without additional growth factors (Methocult H4230 from Stem Cell Technologies, Vancouver, BC.). In some experiments, Methocult H4330 containing erythropoietin (EPO) was used instead of Methocult H4230, or Stem Cell Factor (SCF), 50 ng/mL (Biosource International, Camarillo, Calif.) was added. After culturing for 7-9 days, colonies containing >30 cells are counted. In order to rule out subjective bias in scoring, assays are scored blind.

EXAMPLE 4

[0348] Determination of Bioactivity of Chimera Molecules in Megakaryocyte Proliferation Assay

[0349] Methods

[0350] 1. Bone Marrow Proliferation Assay

[0351] a. CD34+ Cell Purification:

[0352] Between 15-20 mL bone marrow aspirates were obtained from normal allogeneic marrow donors after informed consent. Cells were diluted 1:3 in phosphate buffered saline (PBS, Gibco-BRL), 30 mL were layered over 15 mL Histopaque-1077 (Sigma) and centrifuged for 30 minutes at 300 RCF. The mononuclear interface layer was collected and washed in PBS. CD34+ cells were enriched from the mononuclear cell preparation using an affinity column per manufacturers instructions (CellPro, Inc, Bothell Wash.). After enrichment, the purity of CD34+ cells was 70% on average as determined by using flow cytometric analysis using anti CD34 monoclonal antibody conjugated to fluorescein and anti CD38 conjugated to phycoerythrin (Becton Dickinson, San Jose Calif.).

[0353] Cells were resuspended at 40,000 cells/mL in X-Vivo 10 media (Bio-Whittaker, Walkersville, Md.) and 1 mL was plated in 12-well tissue culture plates (Costar). The growth factor rhIL-3 was added at 100 ng/mL (pMON5873) was added to some wells. hIL3 variant, pMON13288, was used at 10 ng/mL or 100 ng/mL. Conditioned media from BHK cells transfected with plasmid encoding c-mpl ligand were tested by addition of 100 &mgr;l of supernatant added to 1 mL cultures (approximately a 10% dilution). Cells were incubated at 37° C. for 8-14 days at 5% CO2 in a 37° C. humidified incubator.

[0354] b. Cell Harvest and Analysis:

[0355] At the end of the culture period a total cell count was obtained for each condition. For fluorescence analysis and ploidy determination cells were washed in megakaryocyte buffer (MK buffer, 13.6 mM Sodium Citrate, 1 mM Theophylline, 2.2 &mgr;m PGE1, 11 mM Glucose, 3% w/v BSA, in PBS, pH 7.4,) (Tomer et al., Blood 70(6):1735-1742, 1987) resuspended in 500 &mgr;l of MK buffer containing anti-CD41a FITC antibody (1:200, AMAC, Westbrook, Me.) and washed in MK buffer. For DNA analysis cells were permeablized in MK buffer containing 0.5% Tween 20 (Fisher, Fair Lawn N.J.) for 20 min. on ice followed by fixation in 0.5% Tween-20 and 1% paraformaldehyde (Fisher Chemical) for 30 minutes followed by incubation in Propidium Iodide (Calbiochem La Jolla Calif.) (50 &mgr;g/mL) with RNA-ase (400 U/mL) in 55% v/v MK buffer (200 mOsm) for 1-2 hours on ice. Cells were analyzed on a FACScan or Vantage flow cytometer (Becton Dickinson, San Jose, Calif.). Green fluorescence (CD41a-FITC) was collected along with linear and log signals for red fluorescence (PI) to determine DNA ploidy. All cells were collected to determine the percent of cells that were CD41+. Data analysis was performed using software by LYSIS (Becton Dickinson, San Jose, Calif.). Percent of cells expressing the CD41 antigen was obtained from flow cytometry analysis (Percent). Absolute (Abs) number of CD41+ cells/mL was calculated by: (Abs)=(Cell Count)*(Percent)/100.

[0356] 2. Megakaryocyte Fibrin Clot Assay.

[0357] CD34+ enriched population were isolated as described above. Cells were suspended at 25,000 cells/mL with/without cytokine(s) in a media consisting of a base Iscoves IMDM media supplemented with 0.3% BSA, 0.4 mg/mL apo-transferrin, 6.67 &mgr;M FeCl2, 25 &mgr;g/mL CaCl2, 25 &mgr;g/mL L-asparagine, 500 &mgr;g/mL E-amino-n-caproic acid and Penicillin/Streptomycin. Prior to plating into 35 mm plates, thrombin was added (0.25 Units/mL) to initiate clot formation. Cells were incubated at 37° C. for 13 days at 5% CO2 in a 37° C. humidified incubator.

[0358] At the end of the culture period plates were fixed with Methanol:Acetone (1:3), air dried and stored at −200 C. until staining. A peroxidase immunocytochemistry staining procedure was used (Zymed, Histostain-SP. San Francisco, Calif.) using a cocktail of primary monoclonal antibodies consisting of anti CD41a, CD42 and CD61.

[0359] Colonies were counted after staining and classified as negative, CFU-MK (small colonies, 1-2 foci and less that approx. 25 cells), BFU-MK (large, multi-foci colonies with >25 cells) or mixed colonies (mixture of both positive and negative cells.

EXAMPLE 4

[0360] Ex Vivo Expansion of CD34+ Cells from Peripheral Blood using Chimera Molecules pMON13056 and pMON13148 ± SCF

[0361] Flow Cytometry Evaluation

[0362] The percentage of CD34+ cells in the thawed peripheral blood cell population was determined by flow cytometry. Cells were removed from the selected cell population and placed into two centrifuge tube and washed once in 9/1% albumin Phosphate buffer (PAB). Twenty microliters of anti-CD34 monoclonal antibody (8G12-FITC) or mouse monoclonal antibody IgG-FITC control was added to the tube. The tubes were incubated for 15 minutes on ice. The cells were washed once with PAB and resuspended in approximately 0.5 mL PAB. Propidium iodide (2 ug/mL) was added to each tube just prior to the analysis on the FACSort or FACScan. Selected cells that contain greater than 80% CD34+ cells were used to initiate the cultures.

[0363] On day 12, cultures were harvested and evaluated with CD41A-FITC (a megakaryocyte marker), CD15-FITC and CD11b-PE (early to late neutrophil marker) and CD34 by flow cytometry, using the same processes of preparation and analysis as described above.

[0364] Colony Assay Evaluation

[0365] Colony assay evaluation was performed on day 0 with 500-1000 selected CD34+ cells per dish and again on day 12 of culture with 5,000-10,000 cultured cells per dish. The cells were added to a colony assay culture tube containing 3 mL of Terry Fox Iscove's based methylcellulose and the following growth factors: 20 ng/mL SCF, 10 U/mL EPO, 300 U/mL GM-CSF, 300 U/mL G-CSF, 30 U/mL IL3 and 40 ng/mL IL6. Two 35 mm tissue culture dishes containing 1 mL were set up. All dishes were incubated at 37° C., 5% carbon dioxide, 5% oxygen and high humidity for 13-15 days. The dishes were scored for myeloid (CFU-GM), erythroid (BFU-E) or mixed myeloid and erythroid colonies (CFU-mix) using a Nikon SMZU stereoscope.

[0366] Cell Morphology Evaluation

[0367] On day 12 of culture cells were analyzed for cell morphology after Wright-Giemsa staining. Cultured cells were cytocentrifuged onto slides at 1000 rpm for 4 minutes. Each slide contained approximately 10000-20000 cells. Slides were allowed to air dry before staining with 0.5 mL Wright-Giemsa for 1 minutes and 0.5 mL tap water for 1-2 minutes. Slides were cover-slipped and evaluated using a Microstar light microscope. A differential cell count of neutrophils, megakaryocytes and other blood cells was performed.

[0368] Results

[0369] CD34+ Selection

[0370] Studies were performed on CD34+ cells selected using the Isolex™ 300 magnetic Cell Separator from apheresis products from normal donors mobilized with G-CSF. The selected cells were stored in X-VIVO 10 +12.5% HSA containing 10% DMSO in liquid nitrogen until required. Cultures were initiated as described in the methods section.

[0371] Proliferation Index of Cultures at Day 12

[0372] The proliferation index of cultures was calculated by diving the cell concentration at day 5-7 by 5×104 and then multiplying it by the cell concentration at day 12 divided by 1×105. A summary of the proliferation index obtained from these CD34+ cell cultures is shown in Table 4.

[0373] Flow Cytometry Evaluation of Neutrophil Precursors

[0374] The percentage of neutrophil precursors in the CD34+ cell cultures at day 12 was assessed by flow cytometry using the CD15 marker for early to late neutrophil precursors and the CD11b marker found on late neutrophil precursors determined is shown in Table 4.

[0375] Flow Cytometry Evaluation of Megakaryocytes

[0376] The percentage of Mks in the CD34+ cell cultures was assessed by flow cytometry using the CD41a marker for megakaryocytes. The percentage of Mks observed in the CD34+ cell cultures is shown in Table 4.

[0377] Flow Cytometry Evaluation of CD34+ Cells

[0378] The percentage of CD34+ cells present in the cultures at day 12 was determined by flow cytometry. The percentage of CD34+ cells still remaining in the cultures at day 12 ranged from 0.103-19.3%, with no significant difference or patterns observed with the different growth factor combinations.

[0379] Total Number of Megakaryocytes Generated in Culture

[0380] The total number of megakaryocytes present in each culture is calculated by multiplying the total number of cells at day 12 by the percentage of CD15+ cells and is shown in Table 4.

[0381] Colony Forming Unit Granulocyte-Macrophage (CFU-GM) Index

[0382] CFU-GM index is calculate by dividing the total number of GM-colonies obtained at day 1L2 by the number of GM-colonies obtained at day 0. A CFU-GM index of 1 indicates that the number of colonies at day 12 is equivalent to the number of colonies at the start of the culture. A summary of the CFU-GM index for these cultures is shown in Table 4.

[0383] Colony Forming Unit (CFU) Index

[0384] CFU index is calculated by dividing the total number of colonies (CFU-GM, BFU-E and mixed) obtained at day 12 by the total number of colonies obtained at day 0. A CFU index of 1 indicates that the number of colonies at day 12 is equivalent to the number of colonies at the start of the culture. A summary of the CFU index for these cultures is shown in Table 4. 3 TABLE 4 Ex-vivo Expansion Growth Donor Donor Donor Donor Donor Assay Factor #1 #2 #3 #4 #5 Proliferation pMON13056 39.4 73.4 ND 5.7 5.7 Index of CD34+ pMON13056 + SCF 135 206 37.4 17.4 6.4 Cell Cultures at pMON13148 21.4 23.8 ND ND ND Day 12 pMON13148 + SCF 88.1 117.7 ND ND ND native 9 4.1 10.7 1 1.4 hIL-3 native 70.5 61.3 62.3 22.6 12.2 hIL-3 + SCF Percentage CD15+ pMON13056 57 39.6 61.1 56 67.5 Cells at Day 12 of pMON13056 + SCF 70.8 45.4 72.7 46.3 87.4 CD34+ Cultures pMON13148 47.3 58.6 ND ND ND pMON13418 + SCF 38.7 31.7 ND ND ND native 25.6 10.5 43.3 26 18.2 hIL-3 native 17.7 11.5 55 12.4 24.2 hIL-3 + SCF Percentage CD41+ pMON13056 12.6 16.5 18.2 3.4 4.6 Cells at Day 12 of pMON13056 + SCF 7.4 8.3 5.5 4.8 1.8 CD34+ Cultures pMON13148 6 9.1 ND ND ND pmon13148 + SCF 14.1 8.3 ND ND ND native 18.9 14.1 13.7 4.2 5.5 hIL-3 native 15.3 10.7 12.9 7.4 15 hIL-3 + SCF Total Number of pMON13056 20 49 ND 0.8 1 Megakaryoctes pMON13056 + SCF 40 68 8.2 3.4 0.5 (E+05) In Day 10-12 pMON13148 5.2 8.7 ND ND ND Cultures pMON13148 + SCF 50 52 ND ND ND native 6.8 2.3 5.9 0.2 0.3 hIL-3 native 43 26 32 16 7.4 hIL-3 + SCF Colony Forming pMON13056 0.9 3.2 ND 0.2 0.1 Unit Granulocyte pMON13056 + SCF 1 3 0.7 1.1 0.04 Macrophage (CFU- pMON13148 0.5 0.8 ND ND ND GM) Index pMON13148 + SCF 1.2 3.2 ND ND ND native 0.2 0.06 0.03 0.03 0.03 hIL-3 native 1.9 1.1 0.3 0.6 0.3 hIL-3 + SCF Colony Forming pMON13056 1.4 5.1 ND 0.2 0.2 Unit-Index pMON13056 + SCF 1.3 4.3 0.3 1.1 0.2 pMON13148 0.7 1.1 ND ND ND pMON13148 + SCF 1.6 5.2 ND ND ND native 0.2 0.1 0.03 0.03 0.04 hIL-3 native 2.7 1.5 0.3 0.5 0.4 hIL-3 + SCF

EXAMPLE 5

[0385] Ex Vivo Expansion of CD34+ Cells from Bone Marrow using pMON13056 vs. Native IL-3 ± G-CSF

[0386] Cells were cultured as in Example 4 except CD34+ cells were isolated from normal bone marrow. Native IL-3, IL-3 variant (pMON13288) and G-CSF were used at 50 ng/mL and pMON13056 was used at 100 ng/ml of culture medium. Starting cell number for each treatment was 20×10E4. The total cell expansion is shown in Table 5. 4 TABLE 5 Treatment Donor 1 Donor 2 native IL-3  42 × 10E4 169 × 10E4 pMON13288 114 × 10E4 259 × 10E4 G-CSF  14 × 10E4  32 × 10E4 pMON13288 194 × 10E4 609 × 10E4 and G-CSF pMON13056 219 × 10E4 621 × 10E4

[0387] Amino acids are shown herein by standard one letter or three letter abbreviations as follows: 5 Abbreviated Designation Amino Acid A Ala Alanine C Cys Cysteine D Asp Aspartic acid B Glu Glutamic acid F Phe Phenylalanine G Gly Glycine H His Histidine I Ile Isoleucine K Lys Lysine L Leu Leucine M Met Methionine N Asn Asparagine P Pro Proline Q Gln Glutamine R Arg Arginine S Ser Serine T Thr Threonine V Val Valine W Trp Tryptophan Y Tyr Tyrosine

[0388] Further details known to those skilled in the art may be found in T. Maniatis, et al., Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory (1982) and references cited therein, incorporated herein by reference; and in J. Sambrook, et al., Molecular Cloning, A Laboratory Manual, 2nd edition, Cold Spring Harbor Laboratory (1989) and references cited therein, incorporated herein by reference.

[0389] Additional details on the IL-3 variants of the present invention may be found in co-pending U.S. patent application Ser. No. 08/411,795 (WO 94/12638) which is hereby incorporated by reference in its entirety as if written herein.

[0390] Additional details on how to make the chimera protein can be found in WO 95/21254, WO 92/04455 and WO 91/02754.

[0391] Additional details about the lymphokine and the variants thereof can be found in U.S. Pat. Nos. 4,810,643, and 5,218,092 and E.P. Application 02174004.

[0392] All references, patents or applications cited herein are incorporated by reference in their entirety as if written herein.

[0393] Various other examples will be apparent to the person skilled in the art after reading the present disclosure without departing from the spirit and scope of the invention. It is intended that all such other examples be included within the scope of the appended claims. 6                    #              SEQUENCE LIS #TING (1) GENERAL INFORMATION:    (iii) NUMBER OF SEQUENCES: 197 (2) INFORMATION FOR SEQ ID NO: 1:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 133 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- may or may not precede the                amino aci #d in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 17           (D) OTHER INFORMATION:  #/note= “Xaa at position 17 is Ser,                Lys, Gly, # Asp, Met, Gln, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Asn,                His, Leu, # Ile, Phe, Arg, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 19           (D) OTHER INFORMATION:  #/note= “Xaa at positiion 19 is Met,                Phe, Ile, # Arg, Gly, Ala, or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 20           (D) OTHER INFORMATION:  #/note= “Xaa at position 20 is Ile,                Cys, Gln, # Glu, Arg, Pro, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 21           (D) OTHER INFORMATION:  #/note= “Xaa at position 21 is Asp,                Phe, Lys, # Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser,                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 22           (D) OTHER INFORMATION:  #/note= “Xaa at position 22 is Glu,                Trp, Pro, # Ser, Ala, His, Asp, Asn, Gln, Leu, Val,                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Ile,                Val, Ala, # Leu, Gly, Trp, Lys, Phe, Ser, or                Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 24           (D) OTHER INFORMATION:  #/note= “Xaa at position 24 is Ile,                Gly, Val, # Arg, Ser, Phe, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 25           (D) OTHER INFORMATION:  #/note= “Xaa at position 25 is Thr,                His, Gly, # Gln, Arg, Pro, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 26           (D) OTHER INFORMATION:  #/note= “Xaa at position 26 is His,                Thr, Phe, # Gly, Arg, Ala, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 27           (D) OTHER INFORMATION:  #/note= “Xaa at position 27 is Leu,                Gly, Arg, # Thr, Ser, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 28           (D) OTHER INFORMATION:  #/note= “Xaa at position 28 is Lys,                Arg, Leu, # Gln, Gly, Pro, Val, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 29           (D) OTHER INFORMATION:  #/note= “Xaa at position 29 is Gln,                Asn, Leu, # Pro, Arg, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 30           (D) OTHER INFORMATION:  #/note= “Xaa at position 30 is Pro,                His, Thr, # Gly, Asp, Gln, Ser, Leu, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 31           (D) OTHER INFORMATION:  #/note= “Xaa at position 31 is Pro,                Asp, Gly, # Ala, Arg, Leu, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Leu,                Val, Arg, # Gln, Asn, Gly, Ala, or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 33           (D) OTHER INFORMATION:  #/note= “Xaa at position 33 is Pro,                Leu, Gln, # Ala, Thr, or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 34           (D) OTHER INFORMATION:  #/note= “Xaa at position 34 is Leu,                Val, Gly, # Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe,                Ile, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 35           (D) OTHER INFORMATION:  #/note= “Xaa at position 35 is Leu,                Ala, Gly, # Asn, Pro, Gln, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 36           (D) OTHER INFORMATION:  #/note= “Xaa at position 36 is Asp,                Leu, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Phe,                Ser, Pro, # Trp, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 38           (D) OTHER INFORMATION:  #/note= “Xaa at position 38 is Asn,                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 40           (D) OTHER INFORMATION:  #/note= “Xaa at position 40 is Leu,                Trp, or  #Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 41           (D) OTHER INFORMATION:  #/note= “Xaa at position 41 is Asn,                Cys, Arg, # Leu, His, Met, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Gly,                Asp, Ser, # Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr #,                Ile, Met, # or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 43           (D) OTHER INFORMATION:  #/note= “Xaa at position 43 is Glu,                Asn, Tyr, # Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly #,                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 44           (D) OTHER INFORMATION:  #/note= “Xaa at position 44 is Asp,                Ser, Leu, # Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala #,                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 45           (D) OTHER INFORMATION:  #/note= “Xaa at position 45 is Gln,                Pro, Phe, # Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg #,                Ser, Ala, # Ile, Glu, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Asp,                Phe, Ser, # Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr #,                Ile, Val, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 47           (D) OTHER INFORMATION:  #/note= “Xaa at position 47 is Ile,                Gly, Val, # Ser, Arg, Pro, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 48           (D) OTHER INFORMATION:  #/note= “Xaa at position 48 is Leu,                Ser, Cys, # Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met #,                Val, or  #Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 49           (D) OTHER INFORMATION:  #/note= “Xaa at position 49 is Met,                Arg, Ala, # Gly, Pro, Asn, His, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Glu,                Leu, Thr, # Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His #,                Phe, Met, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Asn,                Arg, Met, # Pro, Ser, Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 52           (D) OTHER INFORMATION:  #/note= “Xaa at position 52 is Asn,                His, Arg, # Leu, Gly, Ser, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 53           (D) OTHER INFORMATION:  #/note= “Xaa at position 53 is                Leu, Thr, # Ala, Gly, Glu, Pro, Lys, Ser, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 54           (D) OTHER INFORMATION:  #/note= “Xaa at position 54 is Arg,                Asp, Ile, # Ser, Val, Thr, Gln, Asn, Lys, His, Ala,                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Arg,                Thr, Val, # Ser, Leu, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 56           (D) OTHER INFORMATION:  #/note= “Xaa at position 56 is Pro,                Gly, Cys, # Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr,                Phe, Leu, # Val, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 57           (D) OTHER INFORMATION:  #/note= “Xaa at position 57 is Asn                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 58           (D) OTHER INFORMATION:  #/note= “Xaa at position 58 is Leu,                Ser, Asp, # Arg, Gln, Val, or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 59           (D) OTHER INFORMATION:  #/note= “Xaa at position 59 is Glu,                Tyr, His, # Leu, Pro, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 60           (D) OTHER INFORMATION:  #/note= “Xaa at position 60 is Ala,                Ser, Pro, # Tyr, Asn, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 61           (D) OTHER INFORMATION:  #/note= “Xaa at position 61 is Phe,                Asn, Glu, # Pro, Lys, Arg, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Asn,                His, Val, # Arg, Pro, Thr, Asp, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 63           (D) OTHER INFORMATION:  #/note= “Xaa at position 63 is Arg,                Tyr, Trp, # Lys, Ser, His, Pro, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 64           (D) OTHER INFORMATION:  #/note= “Xaa at position 64 is Ala,                Asn, Pro, # Ser, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Val,                Thr, Pro, # His, Leu, Phe, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 66           (D) OTHER INFORMATION:  #/note= “Xaa at position 66 is Lys,                Ile, Arg, # Val, Asn, Glu, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 67           (D) OTHER INFORMATION:  #/note= “Xaa at position 67 is Ser,                Ala, Phe, # Val, Gly, Asn, Ile, Pro, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu,                Val, Trp, # Ser, Ile, Phe, Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 69           (D) OTHER INFORMATION:  #/note= “Xaa at position 69 is Gln,                Ala, Pro, # Thr, Glu, Arg, Trp, Gly, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 70           (D) OTHER INFORMATION:  #/note= “Xaa at position 70 is Asn,                Leu, Val, # Trp, Pro, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 71           (D) OTHER INFORMATION:  #/note= “Xaa at position 71 is                Ala, Met, # Leu, Pro, Arg, Glu, Thr, Gln, Trp,                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 72           (D) OTHER INFORMATION:  #/note= “Xaa at position 72 is Ser,                Glu, Met, # Ala, His, Asn, Arg, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Ala,                Glu, Asp, # Leu, Ser, Gly, Thr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 74           (D) OTHER INFORMATION:  #/note= “Xaa at position 74 is Ile,                Met, Thr, # Pro, Arg, Gly, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 75           (D) OTHER INFORMATION:  #/note= “Xaa at position 75 is                Glu, Lys, # Gly, Asp, Pro, Trp, Arg, Ser, Gln,                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 76           (D) OTHER INFORMATION:  #/note= “Xaa at position 76 is Ser,                Val, Ala, # Asn, Trp, Glu, Pro, Gly, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ile,                Ser, Arg, # Thr, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 78           (D) OTHER INFORMATION:  #/note= “Xaa at position 78 is Leu,                Ala, Ser, # Glu, Phe, Gly, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Lys, Thr,                Asn, Met, # Arg, Ile, Gly, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 80           (D) OTHER INFORMATION:  #/note= “Xaa at position 80 is Asn,                Trp, Val, # Gly, Thr, Leu, Glu, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 81           (D) OTHER INFORMATION:  #/note= “Xaa at position 81 is Leu,                Gln, Gly, # Ala, Trp, Arg, Val, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 82           (D) OTHER INFORMATION:  #/note= “Xaa at position 82 is Leu,                Gln, Lys, # Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala #,                Tyr, Phe, # Ile, Met, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 83           (D) OTHER INFORMATION:  #/note= “Xaa at position 83 is Pro,                Ala, Thr, # Trp, Arg, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 84           (D) OTHER INFORMATION:  #/note= “Xaa at position 84 is Cys,                Glu, Gly, # Arg, Met, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 85           (D) OTHER INFORMATION:  #/note= “Xaa at position 85 is Leu,                Asn, Val, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 86           (D) OTHER INFORMATION:  #/note= “Xaa at position 86 is Pro,                Cys, Arg, # Ala, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Leu,                Ser, Trp, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 88           (D) OTHER INFORMATION:  #/note= “Xaa at position 88 is Ala,                Lys, Arg, # Val, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 89           (D) OTHER INFORMATION:  #/note= “Xaa at position 89 is Thr,                Asp, Cys, # Leu, Val, Glu, His, Asn, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 90           (D) OTHER INFORMATION:  #/note= “Xaa at position 90 is Ala,                Pro, Ser, # Thr, Gly, Asp, Ile, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is Ala,                Pro, Ser, # Thr, Phe, Leu, Asp, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 92           (D) OTHER INFORMATION:  #/note= “Xaa at position 92 is Pro,                Phe, Arg, # Ser, Lys, His, Ala, Gly, Ile, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 93           (D) OTHER INFORMATION:  #/note= “Xaa at position 93 is Thr,                Asp, Ser, # Asn, Pro, Ala, Leu, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 94           (D) OTHER INFORMATION:  #/note= “Xaa at position 94 is Arg,                Ile, Ser, # Glu, Leu, Val, Gln, Lys, His, Ala, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is His,                Gln, Pro, # Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala #,                Trp, Phe, # Ile, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 96           (D) OTHER INFORMATION:  #/note= “Xaa at position 96 is Pro,                Lys, Tyr, # Gly, Ile, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 97           (D) OTHER INFORMATION:  #/note= “Xaa at position 97 is Ile,                Val, Lys, # Ala, or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is His,                Ile, Asn, # Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met #,                Val, Lys, # Arg, Tyr, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 99           (D) OTHER INFORMATION:  #/note= “Xaa at position 99 is Ile,                Leu, Arg, # Asp, Val, Pro, Gln, Gly, Ser, Phe,                or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 100           (D) OTHER INFORMATION:  #/note= “Xaa at position 100 is                Lys, Tyr, # Leu, His, Arg, Ile, Ser, Gln, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 101           (D) OTHER INFORMATION:  #/note= “Xaa at position 101 is                Asp, Pro, # Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser #,                Ala, Gly, # Ile, Leu, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 102           (D) OTHER INFORMATION:  #/note= “Xaa at position 102 is Gly,                Leu, Glu, # Lys, Ser, Tyr, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 103           (D) OTHER INFORMATION:  #/note= “Xaa at position 103 is Asp,                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 104           (D) OTHER INFORMATION:  #/note= “Xaa at position 104 is                Trp, Val, # Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala #,                Phe, or  #Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 105           (D) OTHER INFORMATION:  #/note= “Xaa at position 105 is                Asn, Pro, # Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile #,                Asp, or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 106           (D) OTHER INFORMATION:  #/note= “Xaa at position 106 is Glu,                Ser, Ala, # Lys, Thr, Ile, Gly, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 108           (D) OTHER INFORMATION:  #/note= “Xaa at position 108 is Arg,                Lys, Asp, # Leu, Thr, Ile, Gln, His, Ser, Ala, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Arg,                Thr, Pro, # Glu, Tyr, Leu, Ser, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 110           (D) OTHER INFORMATION:  #/note= “Xaa at position 110 is Lys,                Ala, Asn, # Thr, Leu, Arg, Gln, His, Glu, Ser, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 111           (D) OTHER INFORMATION:  #/note= “Xaa at position 111 is Leu,                Ile, Arg, # Asp, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 112           (D) OTHER INFORMATION:  #/note= “Xaa at position 112 is Thr,                Val, Gln, # Tyr, Glu, His, Ser, or Phe”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 113           (D) OTHER INFORMATION:  #/note= “Xaa at position 113 is Phe,                Ser, Cys, # His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val #,                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 114           (D) OTHER INFORMATION:  #/note= “Xaa at position 114 is Tyr,                Cys, His, # Ser, Trp, Arg, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 115           (D) OTHER INFORMATION:  #/note= “Xaa at position 115 is                Leu, Asn, # Val, Pro, Arg, Ala, His, Thr, Trp, or                Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 116           (D) OTHER INFORMATION:  #/note= “Xaa at position 116 is Lys,                Leu, Pro, # Thr, Met, Asp, Val, Glu, Arg, Trp, Ser,                Asn, His, # Ala, Tyr, Phe, Gln, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 117           (D) OTHER INFORMATION:  #/note= “Xaa at position 117 is Thr,                Ser, Asn, # Ile, Trp, Lys, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 118           (D) OTHER INFORMATION:  #/note= “Xaa at position 118 is Leu,                Ser, Pro, # Ala, Glu, Cys, Asp, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 119           (D) OTHER INFORMATION:  #/note= “Xaa at position 119 is Glu,                Ser, Lys, # Pro, Leu, Thr, Tyr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 120           (D) OTHER INFORMATION:  #/note= “Xaa at position 120 is Asn,                Ala, Pro, # Leu, His, Val, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 121           (D) OTHER INFORMATION:  #/note= “Xaa at position 121 is Ala,                Ser, Ile, # Asn, Pro, Lys, Asp, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 122           (D) OTHER INFORMATION:  #/note= “Xaa at position 122 is                Gln, Ser, # Met, Trp, Arg, Phe, Pro, His, Ile, Tyr,                or  Cy #s”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 123           (D) OTHER INFORMATION:  #/note= “Xaa at position 123 is Ala,                Met, Glu, # His, Ser, Pro, Tyr, or Leu”         (xi) SEQUENCE DESCRIPTION: SEQ  #ID NO: 1: Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Th #r Ser Trp Val Asn Cys 1               5    #                10   #                15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa             20       #            25       #            30 Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa         35           #        40           #        45 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa     50               #    55               #    60 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa 65                   #70                   #75                   #80 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa                 85   #                90   #                95 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ph #e Xaa Xaa Xaa Xaa Xaa             100       #           105       #           110 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Gln Gln Thr Thr Leu         115           #       120           #       125 Ser Leu Ala Ile Phe     130 (2) INFORMATION FOR SEQ ID NO: 2:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 133 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- may or may not precede                the amino # acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 17           (D) OTHER INFORMATION:  #/note= “Xaa at position 17 is Ser,                Gly, Asp, # Met, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Asn,                His, or  #Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 19           (D) OTHER INFORMATION:  #/note= “Xaa at position 19 is Met                or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 21           (D) OTHER INFORMATION:  #/note=“Xaa at position 21 is Asp                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Ile,                Ala, Leu, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 24           (D) OTHER INFORMATION:  #/note= “Xaa at position 24 is Ile,                Val, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 25           (D) OTHER INFORMATION:  #/note= “Xaa at position 25 is Thr,                His, Gln, # or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 26           (D) OTHER INFORMATION:  #/note= “Xaa at position 26 is His                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 29           (D) OTHER INFORMATION:  #/note= “Xaa at position 29 is Gln,                Asn, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 30           (D) OTHER INFORMATION:  #/note= “Xaa at position 30 is Pro,                Gly, or  #Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 31           (D) OTHER INFORMATION:  #/note= “Xaa at position 31 is Pro,                Asp, Gly, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Leu,                Arg, Gln, # Asn, Gly, Ala, or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 33           (D) OTHER INFORMATION:  #/note= “Xaa at position 33 is Pro                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 34           (D) OTHER INFORMATION:  #/note= “Xaa at position 34 is Leu,                Val, Gly, # Ser, Lys, Ala, Arg, Gln, Glu, Ile, Phe,                Thr, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 35           (D) OTHER INFORMATION:  #/note= “Xaa at position 35 is Leu,                Ala, Asn, # Pro, Gln, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Phe,                Ser, Pro, # or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 38           (D) OTHER INFORMATION:  #/note=“Xaa at position 38 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Gly,                Asp, Ser, # Cys, Ala, Asn, Ile, Leu, Met, Tyr,                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 44           (D) OTHER INFORMATION:  #/note=“Xaa at position 44 is Asp                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 45           (D) OTHER INFORMATION:  #/note= “Xaa at position 45 is Gln,                Val, Met, # Leu, Thr, Ala, Asn, Glu, Ser, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Asp,                Phe, Ser, # Thr, Ala, Asn, Gln, Glu, His, Ile,                Lys, Tyr, # Val, or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Glu,                Ala, Asn, # Ser, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Asn,                Arg, Met, # Pro, Ser, Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 54           (D) OTHER INFORMATION:  #/note=“Xaa at position 54 is Arg                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Arg,                Thr, Val, # Leu, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 56           (D) OTHER INFORMATION:  #/note= “Xaa at position 56 is Pro,                Gly, Ser, # Gln, Ala, Arg, Asn, Glu, Leu, Thr, Val,                or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 60           (D) OTHER INFORMATION:  #/note= “Xaa at position 60 is Ala                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Asn,                Pro, Thr, # or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 63           (D) OTHER INFORMATION:  #/note= “Xaa at position 63 is Arg                or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 64           (D) OTHER INFORMATION:  #/note= “Xaa at position 64 is Ala                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Val                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 66           (D) OTHER INFORMATION:  #/note= “Xaa at position 66 is Lys                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 67           (D) OTHER INFORMATION:  #/note= “Xaa at position 67 is Ser                Phe or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu,                Ile, Phe, # or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 69           (D) OTHER INFORMATION:  #/note= “Xaa at position 69 is Gln,                Ala, Pro, # Thr, Glu, Arg, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 71           (D) OTHER INFORMATION:  #/note= “Xaa at position 71 is Ala,                Pro, or  #Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 72           (D) OTHER INFORMATION:  #/note= “Xaa at position 72 is Ser,                Glu, Arg, # or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Ala                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 76           (D) OTHER INFORMATION:  #/note= “Xaa at position 76 is Ser,                Val, Ala, # Asn, Glu, Pro, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ile                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is                Lys, Thr, # Gly, Asn, Met, Arg, Ile, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 80           (D) OTHER INFORMATION:  #/note= “Xaa at position 80 is Asn,                Gly, Glu, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 82           (D) OTHER INFORMATION:  #/note= “Xaa at position 82 is Leu,                Gln, Trp, # Arg, Asp, Ala, Asn, Glu, His, Ile,                Met, Phe, # Ser, Thr, Tyr, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 83           (D) OTHER INFORMATION:  #/note= “Xaa at position 83 is Pro                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 85           (D) OTHER INFORMATION:  #/note= “Xaa at position 85 is Leu                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Leu                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 88           (D) OTHER INFORMATION:  #/note= “Xaa at position 88 is Ala                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is Ala                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 93           (D) OTHER INFORMATION:  #/note= “Xaa at position 93 is Thr,                Asp, Ser, # Pro, Ala, Leu, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is His,                Pro, Arg, # Val, Leu, Gly, Asn, Phe, Ser, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 96           (D) OTHER INFORMATION:  #/note= “Xaa at position 96 is Pro                or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 97           (D) OTHER INFORMATION:  #/note= “Xaa at position 97 is Ile                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is His,                Ile, Asn, # Leu, Ala, Thr, Arg, Gln, Lys,                Met, Ser, # Tyr, Val, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 99           (D) OTHER INFORMATION:  #/note= “Xaa at position 99 is Ile,                Leu, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 100           (D) OTHER INFORMATION:  #/note= “Xaa at position 100 is Lys,                Arg, Ile, # Gln, Pro, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 101           (D) OTHER INFORMATION:  #/note= “Xaa at position 101 is Asp,                Pro, Met, # Lys, Thr, His, Asn, Ile, Leu, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 104           (D) OTHER INFORMATION:  #/note= “Xaa at position 104 is Trp                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 105           (D) OTHER INFORMATION:  #/note= “Xaa at position 105 is                Asn, Pro, # Ala, Ser, Trp, Gln, Tyr, Leu, Lys, Ile,                Asp, or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 106           (D) OTHER INFORMATION:  #/note= “Xaa at position 106 is Glu                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 108           (D) OTHER INFORMATION:  #/note=“Xaa at position 108 is Arg,                Ala, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Arg,                Thr, Glu, # Leu, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 112           (D) OTHER INFORMATION:  #/note= “Xaa at position 112 is Thr,                Val, or  #Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 114           (D) OTHER INFORMATION:  #/note= “Xaa at position 114 is Tyr                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 115           (D) OTHER INFORMATION:  #/note= “Xaa at position 115 is Leu                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 116           (D) OTHER INFORMATION:  #/note= “Xaa at position 116 is Lys,                Thr, Val, # Trp, Ser, Ala, His, Met, Phe, Tyr, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 117           (D) OTHER INFORMATION:  #/note= “Xaa at position 117 is Thr                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 120           (D) OTHER INFORMATION:  #/note= “Xaa at position 120 is Asn,                Pro, Leu, # His, Val, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 121           (D) OTHER INFORMATION:  #/note= “Xaa at position 121 is Ala,                Ser, Ile, # Asn, Pro, Asp, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 122           (D) OTHER INFORMATION:  #/note= “Xaa at position 122 is                Gln, Ser, # Met, Trp, Arg, Phe, Pro, His, Ile, Tyr,                or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 123           (D) OTHER INFORMATION:  #/note= “Xaa at position 123 is Ala,                Met, Glu, # His, Ser, Pro, Tyr, or Leu”         (xi) SEQUENCE DESCRIPTION: SEQ  #ID NO: 2: Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Th #r Ser Trp Val Asn Cys 1               5    #                10   #                15 Xaa Xaa Xaa Ile Xaa Glu Xaa Xaa Xaa Xaa Le #u Lys Xaa Xaa Xaa Xaa             20       #            25       #            30 Xaa Xaa Xaa Asp Xaa Xaa Asn Leu Asn Xaa Gl #u Xaa Xaa Xaa Ile Leu         35           #        40           #        45 Met Xaa Xaa Asn Leu Xaa Xaa Xaa Asn Leu Gl #u Xaa Phe Xaa Xaa Xaa     50               #    55               #    60 Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Ile Gl #u Xaa Xaa Leu Xaa Xaa 65                   #70                   #75                   #80 Leu Xaa Xaa Cys Xaa Pro Xaa Xaa Thr Ala Xa #a Pro Xaa Arg Xaa Xaa                 85   #                90   #                95 Xaa Xaa Xaa Xaa Xaa Gly Asp Xaa Xaa Xaa Ph #e Xaa Xaa Lys Leu Xaa             100       #           105       #           110 Phe Xaa Xaa Xaa Xaa Leu Glu Xaa Xaa Xaa Xa #a Gln Gln Thr Thr Leu         115           #       120           #       125 Ser Leu Ala Ile Phe     130 (2) INFORMATION FOR SEQ ID NO: 3:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 133 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- may or may not precede                the amino # acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 17           (D) OTHER INFORMATION:  #/note= “Xaa at position 17 is Ser,                Gly, Asp, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Asn,                His, or  #Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Ile,                Ala, Leu, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 25           (D) OTHER INFORMATION:  #/note= “Xaa at position 25 is Thr,                His, or  #Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 26           (D) OTHER INFORMATION:  #/note= “Xaa at position 26 is His                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 29           (D) OTHER INFORMATION:  #/note=“Xaa at position 29 is Gln                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 30           (D) OTHER INFORMATION:  #/note= “Xaa at position 30 is Pro                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Leu,                Arg, Asn, # or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 34           (D) OTHER INFORMATION:  #/note= “Xaa at position 34 is Leu,                Val, Ser, # Ala, Arg, Gln, Glu, Ile, Phe, Thr, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 35           (D) OTHER INFORMATION:  #/note= “Xaa at position 35 is Leu,                Ala, Asn, # or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 38           (D) OTHER INFORMATION:  #/note= “Xaa at position 38 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Gly,                Asp, Ser, # Ala, Asn, Ile, Leu, Met, Tyr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 45           (D) OTHER INFORMATION:  #/note= “Xaa at position 45 is Gln,                Val, Met, # Leu, Ala, Asn, Glu, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Asp,                Phe, Ser, # Gln, Glu, His, Val, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Glu,                Asn, Ser, # or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Asn,                Arg, Pro, # Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Arg,                Leu, or  #Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 56           (D) OTHER INFORMATION:  #/note= “Xaa at position 56 is Pro,                Gly, Ser, # Ala, Asn, Val, Leu, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Asn,                Pro, or  #Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 64           (D) OTHER INFORMATION:  #/note= “Xaa at position 64 is Ala                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Val                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 67           (D) OTHER INFORMATION:  #/note= “Xaa at position 67 is Ser                or Phe”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu                or Phe”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 69           (D) OTHER INFORMATION:  #/note= “Xaa at position 69 is Gln,                Ala, Glu, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 76           (D) OTHER INFORMATION:  #/note= “Xaa at position 76 is Ser,                Val, Asn, # Pro, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ile                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Lys,                Asn, Met, # Arg, Ile, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 80           (D) OTHER INFORMATION:  #/note= “Xaa at position 80 is Asn,                Gly, Glu, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 82           (D) OTHER INFORMATION:  #/note= “Xaa at position 82 is Leu,                Gln, Trp, # Arg, Asp, Asn, Glu, His, Met, Phe, Ser,                Thr, Tyr, # or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Leu                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 88           (D) OTHER INFORMATION:  #/note= “Xaa at position 88 is Ala                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is Ala                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 93           (D) OTHER INFORMATION:  #/note= “Xaa at position 93 is Thr,                Asp, or  #Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is His,                Pro, Arg, # Val, Gly, Asn, Ser, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is His,                Ile, Asn, # Ala, Thr, Gln, Glu, Lys, Met, Ser, Tyr,                Val, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 99           (D) OTHER INFORMATION:  #/note= “Xaa at position 99 is Ile                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 100           (D) OTHER INFORMATION:  #/note= “Xaa at position 100 is Lys                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION:  101           (D) OTHER INFORMATION:  #/note= “Xaa at position 101 is Asp,                Pro, Met, # Lys, Thr, His, Asn, Ile, Leu, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 105           (D) OTHER INFORMATION:  #/note= “Xaa at position 105 is Asn,                Pro, Ser, # Ile, or Asp”     (ix) FEATURE:           (A) NAME/KEY:  Modified #-site           (B) LOCATION:  108           (D) OTHER INFORMATION:  # /note= “Xaa at position 108 is Arg,                Ala, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Arg,                Thr, Glu, # Leu, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 112           (D) OTHER INFORMATION:  #/note= “Xaa at position 112 is Thr                or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 116           (D) OTHER INFORMATION:  #/note= “Xaa at position 116 is Lys,                Val, Trp, # Ala, His, Phe, Tyr, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 117           (D) OTHER INFORMATION:  #/note= “Xaa at position 117 is Thr                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 120           (D) OTHER INFORMATION:  #/note= “Xaa at position 120 is Asn,                Pro, Leu, # His, Val, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 121           (D) OTHER INFORMATION:  #/note= “Xaa at position 121 is Ala,                Ser, Ile, # Pro, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 122           (D) OTHER INFORMATION:  #/note= “Xaa at position 122 is Gln,                Met, Trp, # Phe, Pro, His, Ile, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 123           (D) OTHER INFORMATION:  #/note= “Xaa at position 123 is Ala,                Met, Glu, # Ser, or Leu”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #3: Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Th #r Ser Trp Val Asn Cys 1               5    #                10   #                15 Xaa Xaa Met Ile Asp Glu Xaa Ile Xaa Xaa Le #u Lys Xaa Xaa Pro Xaa             20       #            25       #            30 Pro Xaa Xaa Asp Phe Xaa Asn Leu Asn Xaa Gl #u Asp Xaa Xaa Ile Leu         35           #        40           #        45 Met Xaa Xaa Asn Leu Arg Xaa Xaa Asn Leu Gl #u Ala Phe Xaa Arg Xaa     50               #    55               #    60 Xaa Lys Xaa Xaa Xaa Asn Ala Ser Ala Ile Gl #u Xaa Xaa Leu Xaa Xaa 65                   #70                   #75                   #80 Leu Xaa Pro Cys Leu Pro Xaa Xaa Thr Ala Xa #a Pro Xaa Arg Xaa Pro                 85   #                90   #                95 Ile Xaa Xaa Xaa Xaa Gly Asp Trp Xaa Glu Ph #e Xaa Xaa Lys Leu Xaa             100       #           105       #           110 Phe Tyr Leu Xaa Xaa Leu Glu Xaa Xaa Xaa Xa #a Gln Gln Thr Thr Leu         115           #       120           #       125 Ser Leu Ala Ile Phe     130 (2) INFORMATION FOR SEQ ID NO: 4:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- or Met-Ala- may or may                not prece #de the amino acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 3           (D) OTHER INFORMATION:  #/note= “Xaa at position 3 is Ser,                Lys, Gly, # Asp, Met, Gln, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 4           (D) OTHER INFORMATION:  #/note= “Xaa at position 4 is Asn,                His, Leu, # Ile, Phe, Arg, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 5           (D) OTHER INFORMATION:  #/note= “Xaa at position 5 is Met,                Phe, Ile, # Arg, Gly, Ala, or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 6           (D) OTHER INFORMATION:  #/note= “Xaa at position 6 is Ile,                Cys, Gln, # Glu, Arg, Pro, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 7           (D) OTHER INFORMATION:  #/note= “Xaa at position 7 is Asp,                Phe, Lys, # Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser,                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 8           (D) OTHER INFORMATION:  #/note= “Xaa at position 8 is Glu,                Trp, Pro, # Ser, Ala, His, Asp, Asn, Gln, Leu, Val,                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 9           (D) OTHER INFORMATION:  #/note= “Xaa at position 9 is                Ile, Val, # Ala, Leu, Gly, Trp, Lys, Phe, Ser or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 10           (D) OTHER INFORMATION:  #/note= “Xaa at position 10 is Ile,                Gly, Val, # Arg, Ser, Phe, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 11           (D) OTHER INFORMATION:  #/note= “Xaa at position 11 is Thr,                His, Gly, # Gln, Arg, Pro, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 12           (D) OTHER INFORMATION:  #/note= “Xaa at position 12 is His,                Thr, Phe, # Gly, Arg, Ala, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 13           (D) OTHER INFORMATION:  #/note= “Xaa at position 13 is Leu,                Gly, Arg, # Thr, Ser, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 14           (D) OTHER INFORMATION:  #/note= “Xaa at position 14 is Lys,                Arg, Leu, # Gln, Gly, Pro, Val, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 15           (D) OTHER INFORMATION:  #/note= “Xaa at position 15 is Gln,                Asn, Leu, # Pro, Arg, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 16           (D) OTHER INFORMATION:  #/note= “Xaa at position 16 is Pro,                His, Thr, # Gly, Asp, Gln, Ser, Leu, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 17           (D) OTHER INFORMATION:  #/note= “Xaa at position 17 is Pro,                Asp, Gly, # Ala, Arg, Leu, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Leu,                Val, Arg, # Gln, Asn, Gly, Ala, or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 19           (D) OTHER INFORMATION:  #/note= “Xaa at position 19 is Pro,                Leu, Gln, # Ala, Thr, or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 20           (D) OTHER INFORMATION:  #/note= “Xaa at position 20 is Leu,                Val, Gly, # Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe,                Ile, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 21           (D) OTHER INFORMATION:  #/note= “Xaa at position 21 is Leu,                Ala, Gly, # Asn, Pro, Gln, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 22           (D) OTHER INFORMATION:  #/note= “Xaa at position 22 is Asp,                Leu, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Phe,                Ser, Pro, # Trp, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 24           (D) OTHER INFORMATION:  #/note= “Xaa at position 24 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 26           (D) OTHER INFORMATION:  #/note= “Xaa at position 26 is Leu,                Trp, or  #Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 27           (D) OTHER INFORMATION:  #/note= “Xaa at position 27 is Asn,                Cys, Arg, # Leu, His, Met, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 28           (D) OTHER INFORMATION:  #/note= “Xaa at position 28 is Gly,                Asp, Ser, # Cys, Ala, Lys, Asn, Thr, Leu, Val, Glu,                Phe, Tyr, # Ile, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 29           (D) OTHER INFORMATION:  #/note= “Xaa at position 29 is Glu,                Asn, Tyr, # Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr,                Gly, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 30           (D) OTHER INFORMATION:  #/note= “Xaa at position 30 is Asp,                Ser, Leu, # Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln,                Ala, or  #Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 31           (D) OTHER INFORMATION:  #/note= “Xaa at position 31 is Gln,                Pro, Phe, # Val, Met, Leu, Thr, Lys, Asp, Asn, Arg,                Ser, Ala, # Ile, Glu, His, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Asp,                Phe, Ser, # Thr, Cys, Glu, Asn, Gln, Lys, His, Ala,                Tyr, Ile, # Val, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 33           (D) OTHER INFORMATION:  #/note= “Xaa at position 33 is Ile,                Gly, Val, # Ser, Arg, Pro, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 34           (D) OTHER INFORMATION:  #/note= “Xaa at position 34 is Leu,                Ser, Cys, # Arg, Ile, His, Phe, Glu, Lys, Thr, Ala,                Met, Val, # or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 35           (D) OTHER INFORMATION:  #/note= “Xaa at position 35 is Met,                Arg, Ala, # Gly, Pro, Asn, His, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 36           (D) OTHER INFORMATION:  #/note= “Xaa at position 36 is Glu,                Leu, Thr, # Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val,                His, Phe, # Met, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Asn,                Arg, Met, # Pro, Ser, Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 38           (D) OTHER INFORMATION:  #/note= “Xaa at position 38 is Asn,                His, Arg, # Leu, Gly, Ser, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 39           (D) OTHER INFORMATION:  #/note= “Xaa at position 39 is                Leu, Thr, # Ala, Gly, Glu, Pro, Lys, Ser, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 40           (D) OTHER INFORMATION:  #/note= “Xaa at position 40 is Arg,                Asp, Ile, # Ser, Val, Thr, Gln, Asn, Lys, His,                Ala, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 41           (D) OTHER INFORMATION:  #/note= “Xaa at position 41 is Arg,                Thr, Val, # Ser, Leu, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Pro,                Gly, Cys, # Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr,                Phe, Leu, # Val, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 43           (D) OTHER INFORMATION:  #/note= “Xaa at position 43 is Asn                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 44           (D) OTHER INFORMATION:  #/note= “Xaa at position 44 is Leu,                Ser, Asp, # Arg, Gln, Val, or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 45           (D) OTHER INFORMATION:  #/note= “Xaa at position 45 is Glu,                Tyr, His, # Leu, Pro, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Ala,                Ser, Pro, # Tyr, Asn, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 47           (D) OTHER INFORMATION:  #/note= “Xaa at position 47 is Phe,                Asn, Glu, # Pro, Lys, Arg, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 48           (D) OTHER INFORMATION:  #/note= “Xaa at position 48 is Asn,                His, Val, # Arg, Pro, Thr, Asp, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 49           (D) OTHER INFORMATION:  #/note= “Xaa at position 49 is Arg,                Tyr, Trp, # Lys, Ser, His, Pro, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Ala,                Asn, Pro, # Ser, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Val,                Thr, Pro, # His, Leu, Phe, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 52           (D) OTHER INFORMATION:  #/note= “Xaa at position 52 is Lys,                Ile, Arg, # Val, Asn, Glu, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 53           (D) OTHER INFORMATION:  #/note= “Xaa at position 53 is Ser,                Ala, Phe, # Val, Gly, Asn, Ile, Pro, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 54           (D) OTHER INFORMATION:  #/note= “Xaa at position 54 is Leu,                Val, Trp, # Ser, Ile, Phe, Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Gln,                Ala, Pro, # Thr, Glu, Arg, Trp, Gly, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 56           (D) OTHER INFORMATION:  #/note= “Xaa at position 56 is Asn,                Leu, Val, # Trp, Pro, or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 57           (D) OTHER INFORMATION:  #/note= “Xaa at position 57 is Ala,                Met, Leu, # Pro, Arg, Glu, Thr, Gln, Trp, or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 58           (D) OTHER INFORMATION:  #/note= “Xaa at position 58 is Ser,                Glu, Met, # Ala, His, Asn, Arg, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 59           (D) OTHER INFORMATION:  #/note= “Xaa at position 59 is Ala,                Glu, Asp, # Leu, Ser, Gly, Thr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 60           (D) OTHER INFORMATION:  #/note= “Xaa at position 60 is Ile,                Met, Thr, # Pro, Arg, Gly, Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 61           (D) OTHER INFORMATION:  #/note= “Xaa at position 61 is                Glu, Lys, # Gly, Asp, Pro, Trp, Arg, Ser, Gln,                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Ser,                Val, Ala, # Asn, Trp, Glu, Pro, Gly, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 63           (D) OTHER INFORMATION:  #/note= “Xaa at position 63 is Ile,                Ser, Arg, # Thr, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 64           (D) OTHER INFORMATION:  #/note= “Xaa at position 64 is Leu,                Ala, Ser, # Glu, Phe, Gly, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Lys,                Thr, Gly, # Asn, Met, Arg, Ile, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 66           (D) OTHER INFORMATION:  #/note= “Xaa at position 66 is Asn,                Trp, Val, # Gly, Thr, Leu, Glu, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 67           (D) OTHER INFORMATION:  #/note= “Xaa at position 67 is Leu,                Gln, Gly, # Ala, Trp, Arg, Val, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu,                Gln, Lys, # Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala #,                Tyr, Phe, # Ile, Met, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 69           (D) OTHER INFORMATION:  #/note= “Xaa at position 69 is Pro,                Ala, Thr, # Trp, Arg, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 70           (D) OTHER INFORMATION:  #/note= “Xaa at position 70 is Cys,                Glu, Gly, # Arg, Met, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 71           (D) OTHER INFORMATION:  #/note= “Xaa at position 71 is Leu,                Asn, Val, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 72           (D) OTHER INFORMATION:  #/note= “Xaa at position 72 is Pro,                Cys, Arg, # Ala, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Leu,                Ser, Trp, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 74           (D) OTHER INFORMATION:  #/note= “Xaa at position 74 is Ala,                Lys, Arg, # Val, or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 75           (D) OTHER INFORMATION:  #/note= “Xaa at position 75 is Thr,                Asp, Cys, # Leu, Val, Glu, His, Asn, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 76           (D) OTHER INFORMATION:  #/note= “Xaa at position 76 is Ala,                Pro, Ser, # Thr, Gly, Asp, Ile, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ala,                Pro, Ser, # Thr, Phe, Leu, Asp, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 78           (D) OTHER INFORMATION:  #/note= “Xaa at position 78 is Pro,                Phe, Arg, # Ser, Lys, His, Ala, Gly, Ile, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Thr,                Asp, Ser, # Asn, Pro, Ala, Leu, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 80           (D) OTHER INFORMATION:  #/note= “Xaa at position 80 is Arg,                Ile, Ser, # Glu, Leu, Val, Gln, Lys, His, Ala, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 81           (D) OTHER INFORMATION:  #/note= “Xaa at position 81 is His,                Gln, Pro, # Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser,                Ala, Trp, # Phe, Ile, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 82           (D) OTHER INFORMATION:  #/note= “Xaa at position 82 is Pro,                Lys, Tyr, # Gly, Ile, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 83           (D) OTHER INFORMATION:  #/note= “Xaa at position 83 is Ile,                Val, Lys, # Ala, or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 84           (D) OTHER INFORMATION:  #/note= “Xaa at position 84 is His,                Ile, Asn, # Leu, Asp, Ala, Thr, Glu, Gln, Ser,                Phe, Met, # Val, Lys, Arg, Tyr, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 85           (D) OTHER INFORMATION:  #/note= “Xaa at position 85 is                Ile, Leu, # Arg, Asp, Val, Pro, Gln, Gly, Ser,                Phe, or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 86           (D) OTHER INFORMATION:  #/note= “Xaa at position 86 is                Lys, Tyr, # Leu, His, Arg, Ile, Ser, Gln, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is                Asp, Pro, # Met, Lys, His, Thr, Val, Tyr, Glu, Asn,                Ser, Ala, # Gly, Ile, Leu, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 88           (D) OTHER INFORMATION:  #/note= “Xaa at position 88 Gly,                Leu, Glu, # Lys, Ser, Tyr, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 89           (D) OTHER INFORMATION:  #/note= “Xaa at position 89 is Asp                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 90           (D) OTHER INFORMATION:  #/note= “Xaa at position 90 is                Trp, Val, # Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys,                Ala, Phe, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is                Asn, Pro, # Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys,                Ile, Asp, # or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 92           (D) OTHER INFORMATION:  #/note= “Xaa at position 92 is Glu,                Ser, Ala, # Lys, Thr, Ile, Gly, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 94           (D) OTHER INFORMATION:  #/note= “Xaa at position 94 is Arg,                Lys, Asp, # Leu, Thr, Ile, Gln, His, Ser, Ala, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is Arg,                Thr, Pro, # Glu, Tyr, Leu, Ser, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 96           (D) OTHER INFORMATION:  #/note= “Xaa at position 96 is Lys,                Asn, Thr, # Leu, Gln, Arg, His, Glu, Ser, Ala,                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 97           (D) OTHER INFORMATION:  #/note= “Xaa at position 97 is Leu,                Ile, Arg, # Asp, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is Thr,                Val, Gln, # Tyr, Glu, His, Ser, or Phe”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 99           (D) OTHER INFORMATION:  #/note= “Xaa at position 99 is Phe,                Ser, Cys, # His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile,                Val, or  #Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 100           (D) OTHER INFORMATION:  #/note= “Xaa at position 100 is Tyr,                Cys, His, # Ser, Trp, Arg, or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 101           (D) OTHER INFORMATION:  #/note= “Xaa at position 101 is Leu,                Asn, Val, # Pro, Arg, Ala, His, Thr, Trp, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 102           (D) OTHER INFORMATION:  #/note= “Xaa at position 102 is                Lys, Leu, # Pro, Thr, Met, Asp, Val, Glu, Arg, Trp,                Ser, Asn, # His, Ala, Tyr, Phe, Gln, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 103           (D) OTHER INFORMATION:  #/note= “Xaa at position 103 is Thr,                Ser, Asn, # Ile, Trp, Lys, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 104           (D) OTHER INFORMATION:  #/note= “Xaa at position 104 is Leu,                Ser, Pro, # Ala, Glu, Cys, Asp, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 105           (D) OTHER INFORMATION:  #/note= “Xaa at position 105 is Glu,                Ser, Lys, # Pro, Leu, Thr, Tyr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 106           (D) OTHER INFORMATION:  #/note= “Xaa at position 106 is Asn,                Ala, Pro, # Leu, His, Val or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 107           (D) OTHER INFORMATION:  #/note= “Xaa at position 107 is Ala,                Ser, Ile, # Asn, Pro, Lys, Asp, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 108           (D) OTHER INFORMATION:  #/note= “Xaa at position 108 is                Gln, Ser, # Met, Trp, Arg, Phe, Pro, His, Ile, Tyr,                or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Ala,                Met, Glu, # His, Ser, Pro, Tyr, or Leu”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #4: Asn Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa 1               5    #                10   #                15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xa #a Xaa Xaa Xaa Xaa Xaa             20       #            25       #            30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa         35           #        40           #        45 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa     50               #    55               #    60 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Xaa Xaa Xaa 65                   #70                   #75                   #80 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Phe Xaa Xaa Xaa                 85   #                90   #                95 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa #a Xaa Xaa Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 5:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- or Met-Ala- may or may                not prece #de the amino acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 3           (D) OTHER INFORMATION:  #/note= “Xaa at position 3 is Ser,                Gly, Asp, # Met, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 4           (D) OTHER INFORMATION:  #/note= “Xaa at position 4 is Asn,                His, or  #Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 5           (D) OTHER INFORMATION:  #/note= “Xaa at position 5 is Met                or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 7           (D) OTHER INFORMATION:  #/note= “Xaa at position 7 is Asp or               Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 9           (D) OTHER INFORMATION:  #/note= “Xaa at position 9 is Ile,                Ala, Leu, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 10           (D) OTHER INFORMATION:  #/note= “Xaa at position 10 is Ile,                Val, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 11           (D) OTHER INFORMATION:  #/note= “Xaa at position 11 is Thr,                His, Gln, # or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 12           (D) OTHER INFORMATION:  #/note= “Xaa at position 12 is His                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 15           (D) OTHER INFORMATION:  #/note= “Xaa at position 15 is Gln,                Asn, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 16           (D) OTHER INFORMATION:  #/note= “Xaa at position 16 is Pro,                Gly, or  #Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 17           (D) OTHER INFORMATION:  #/note= “Xaa at position 17 is Pro,                Asp, Gly, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Leu,                Arg, Gln, # Asn, Gly, Ala, or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 19           (D) OTHER INFORMATION:  #/note= “Xaa at position 19 is Pro                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 20           (D) OTHER INFORMATION:  #/note= “Xaa at position 20 is Leu,                Val, Gly, # Ser, Lys, Ala, Arg, Gln, Glu, Ile, Phe,                Thr, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 21           (D) OTHER INFORMATION:  #/note= “Xaa at position 21 is Leu,                Ala, Asn, # Pro, Gln, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Phe,                Ser, Pro, # or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 24           (D) OTHER INFORMATION:  #/note= “Xaa at position 24 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 28           (D) OTHER INFORMATION:  #/note= “Xaa at position 28 is Gly,                Asp, Ser, # Cys, Ala, Asn, Ile, Leu, Met, Tyr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 30           (D) OTHER INFORMATION:  #/note= “Xaa at position 30 is Asp                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 31           (D) OTHER INFORMATION:  #/note= “Xaa at position 31 is Gln,                Val, Met, # Leu, Thr, Ala, Asn, Glu, Ser, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Asp,                Phe, Ser, # Thr, Ala, Asn, Gln, Glu, His, Ile, Lys,                Tyr, Val, # or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 36           (D) OTHER INFORMATION:  #/note= “Xaa at position 36 is Glu,                Ala, Asn, # Ser, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Asn,                Arg, Met, # Pro, Ser, Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 40           (D) OTHER INFORMATION:  #/note= “Xaa at position 40 is Arg                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 41           (D) OTHER INFORMATION:  #/note= “Xaa at position 41 is Arg,                Thr, Val, # Leu, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Pro,                Gly, Ser, # Gln, Ala, Arg, Asn, Glu, Leu, Thr, Val,                or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Ala                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 48           (D) OTHER INFORMATION:  #/note= “Xaa at position 48 is Asn,                Pro, Thr, # or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 49           (D) OTHER INFORMATION:  #/note= “Xaa at position 49 is Arg                or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Ala                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Val                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 52           (D) OTHER INFORMATION:  #/note= “Xaa at position 52 is Lys                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 53           (D) OTHER INFORMATION:  #/note= “Xaa at position 53 is Ser,                Phe, or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 54           (D) OTHER INFORMATION:  #/note= “Xaa at position 54 is Leu,                Ile, Phe, # or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Gln,                Ala, Pro, # Thr, Glu, Arg, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 57           (D) OTHER INFORMATION:  #/note= “Xaa at position 57 is Ala,                Pro, or  #Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 58           (D) OTHER INFORMATION:  #/note= “Xaa at position 58 is Ser,                Glu, Arg, # or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 59           (D) OTHER INFORMATION:  #/note= “Xaa at position 59 is Ala                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Ser,                Val, Ala, # Asn, Glu, Pro, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 63           (D) OTHER INFORMATION:  #/note= “Xaa at position 63 is Ile                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Lys,                Thr, Gly, # Asn, Met, Arg, Ile, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 66           (D) OTHER INFORMATION:  #/note= “Xaa at position 66 is Asn,                Gly, Glu, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu,                Gln, Trp, # Arg, Asp, Ala, Asn, Glu, His, Ile, Met,                Phe, Ser, # Thr, Tyr, or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 69           (D) OTHER INFORMATION:  #/note= “Xaa at position 69 is Pro                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 71           (D) OTHER INFORMATION:  #/note= “Xaa at position 71 is Leu                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Leu                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 74           (D) OTHER INFORMATION:  #/note= “Xaa at position 74 is Ala                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ala                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Thr,                Asp, Ser, # Pro, Ala, Leu, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 81           (D) OTHER INFORMATION:  #/note= “Xaa at position 81 is His,                Pro, Arg, # Val, Leu, Gly, Asn, Phe, Ser, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 82           (D) OTHER INFORMATION:  #/note= “Xaa at position 82 is Pro                or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 83           (D) OTHER INFORMATION:  #/note= “Xaa at position 83 is Ile                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 84           (D) OTHER INFORMATION:  #/note= “Xaa at position 84 is His,                Ile, Asn, # Leu, Ala, Thr, Arg, Gln, Lys,                Met, Ser, # Tyr, Val, or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 85           (D) OTHER INFORMATION:  #/note= “Xaa at position 85 is Ile,                Leu, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 86           (D) OTHER INFORMATION:  #/note= “Xaa at position 86 is Lys,                Arg, Ile, # Gln, Pro, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Asp,                Pro, Met, # Lys, His, Thr, Asn, Ile, Leu, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 90           (D) OTHER INFORMATION:  #/note= “Xaa at position 90 is Trp                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note=“Xaa at position 91 is Asn,                Pro, Ala, # Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp,                or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 92           (D) OTHER INFORMATION:  #/note= “Xaa at position 92 is Glu                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 94           (D) OTHER INFORMATION:  #/note= “Xaa at position 94 is Arg,                Ala, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is Arg,                Thr, Glu, # Leu, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is Thr,                Val, or  #Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 100           (D) OTHER INFORMATION:  #/note= “Xaa at position 100 is Tyr                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 101           (D) OTHER INFORMATION:  #/note= “Xaa at position 101 is Leu                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 102           (D) OTHER INFORMATION:  #/note= “Xaa at position 102 is Lys,                Thr, Val, # Trp, Ser, Ala, His, Met, Phe, Tyr, or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 103           (D) OTHER INFORMATION:  #/note= “Xaa at position 103 is Thr                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 106           (D) OTHER INFORMATION:  #/note= “Xaa at position 106 is Asn,                Pro, Leu, # His, Val, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 107           (D) OTHER INFORMATION:  #/note= “Xaa at position 107 is Ala,                Ser, Ile, # Asn, Pro, Asp, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 108           (D) OTHER INFORMATION:  #/note= “Xaa at position 108 is Gln,                Ser, Met, # Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Ala,                Met, Glu, # His, Ser, Pro, Tyr, or Leu”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #5: Asn Cys Xaa Xaa Xaa Ile Xaa Glu Xaa Xaa Xa #a Xaa Leu Lys Xaa Xaa 1               5    #                10   #                15 Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Asn Leu As #n Xaa Glu Xaa Xaa Xaa             20       #            25       #            30 Ile Leu Met Xaa Xaa Asn Leu Xaa Xaa Xaa As #n Leu Glu Xaa Phe Xaa         35           #        40           #        45 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xa #a Ile Glu Xaa Xaa Leu     50               #    55               #    60 Xaa Xaa Leu Xaa Xaa Cys Xaa Pro Xaa Xaa Th #r Ala Xaa Pro Xaa Arg 65                   #70                   #75                   #80 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Asp Xaa Xa #a Xaa Phe Xaa Xaa Lys                 85   #                90   #                95 Leu Xaa Phe Xaa Xaa Xaa Xaa Leu Glu Xaa Xa #a Xaa Xaa Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 6:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- or Met-Ala- may or may                not prece #de the amino acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 3           (D) OTHER INFORMATION:  #/note= “Xaa at position 3 is Ser,                Gly, Asp, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 4           (D) OTHER INFORMATION:  #/note= “Xaa at position 4 is Asn,                His, or  #Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 9           (D) OTHER INFORMATION:  #/note= “Xaa at position 9 is Ile,                Ala, Leu, # or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 11           (D) OTHER INFORMATION:  #/note= “Xaa at position 11 is Thr,                His, or  #Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 12           (D) OTHER INFORMATION:  #/note= “Xaa at position 12 is His                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 15           (D) OTHER INFORMATION:  #/note= “Xaa at position 15 is Gln                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 16           (D) OTHER INFORMATION:  #/note= “Xaa at position 16 is Pro                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Leu,                Arg, Asn, # or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 20           (D) OTHER INFORMATION:  #/note= “Xaa at position 20 is Leu,                Val, Ser, # Ala, Arg, Gln, Glu, Ile, Phe, Thr, or Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 21           (D) OTHER INFORMATION:  #/note= “Xaa at position 21 is Leu,                Ala, Asn, # or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 24           (D) OTHER INFORMATION:  #/note= “Xaa at position 24 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 28           (D) OTHER INFORMATION:  #/note= “Xaa at position 28 is Gly,                Asp, Ser, # Ala, Asn, Ile, Leu, Met, Tyr, or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 31           (D) OTHER INFORMATION:  #/note= “Xaa at position 31 is Gln,                Val, Met, # Leu, Ala, Asn, Glu, or Lys”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Asp,                Phe, Ser, # Ala, Gln, Glu, His, Val, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 36           (D) OTHER INFORMATION:  #/note= “Xaa at position 36 is Glu,                Asn, Ser, # or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Asn,                Arg, Pro, # Thr, or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 41           (D) OTHER INFORMATION:  #/note= “Xaa at position 41 is Arg,                Leu, or  #Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Pro,                Gly, Ser, # Ala, Asn, Val, Leu, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 48           (D) OTHER INFORMATION:  #/note= “Xaa at position 48 is Asn,                Pro, or  #Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Ala                or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Val                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 53           (D) OTHER INFORMATION:  #/note= “Xaa at position 53 is Ser                or Phe”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 54           (D) OTHER INFORMATION:  #/note= “Xaa at position 54 is Leu                or Phe”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Gln,                Ala, Glu, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Ser,                Val, Asn, # Pro, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 63           (D) OTHER INFORMATION:  #/note= “Xaa at position 63 is Ile                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Lys,                Asn, Met, # Arg, Ile, or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 66           (D) OTHER INFORMATION:  #/note= “Xaa at position 66 is Asn,                Gly, Glu, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu,                Gln, Trp, # Arg, Asp, Asn, Glu, His, Met, Phe, Ser,                Thr, Tyr, # or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Leu                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 74           (D) OTHER INFORMATION:  #/note= “Xaa at position 74 is Ala                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ala                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Thr,                Asp, or  #Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 81           (D) OTHER INFORMATION:  #/note= “Xaa at position 81 is His,                Pro, Arg, # Val, Gly, Asn, Ser, or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 84           (D) OTHER INFORMATION:  #/note= “Xaa at position 84 is His,                Ile, Asn, # Leu, Ala, Thr, Arg, Gln, Glu, Lys, Met,                Ser, Tyr, # or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 85           (D) OTHER INFORMATION:  #/note= “Xaa at position 85 is Ile                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 86           (D) OTHER INFORMATION:  #/note= “Xaa at position 86 is Lys                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Asp,                Pro, Met, # Lys, His, Pro, Asn, Ile, Leu, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is Asn,                Pro, Ser, # Ile, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 94           (D) OTHER INFORMATION:  #/note=“Xaa at position 94 is Arg,                Ala, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is Arg,                Thr, Glu, # Leu, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is Thr                or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 102           (D) OTHER INFORMATION:  #/note= “Xaa at position 102 is Lys,                Val, Trp, # or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 103           (D) OTHER INFORMATION:  #/note= “Xaa at position 103 is Thr,                Ala, His, # Phe, Tyr, or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 106           (D) OTHER INFORMATION:  #/note= “Xaa at position 106 is Asn,                Pro, Leu, # His, Val, or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 107           (D) OTHER INFORMATION:  #/note= “Xaa at position 107 is Ala,                Ser, Ile, # Pro, or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 108           (D) OTHER INFORMATION:  #/note= “Xaa at position 108 is Gln,                Met, Trp, # Phe, Pro, His, Ile, or Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Ala,                Met, Glu, # Ser, or Leu”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #6: Asn Cys Xaa Xaa Met Ile Asp Glu Xaa Ile Xa #a Xaa Leu Lys Xaa Xaa 1               5    #                10   #                15 Pro Xaa Pro Xaa Xaa Asp Phe Xaa Asn Leu As #n Xaa Glu Asp Xaa Xaa             20       #            25       #            30 Ile Leu Met Xaa Xaa Asn Leu Arg Xaa Xaa As #n Leu Glu Ala Phe Xaa         35           #        40           #        45 Arg Xaa Xaa Lys Xaa Xaa Xaa Asn Ala Ser Al #a Ile Glu Xaa Xaa Leu     50               #    55               #    60 Xaa Xaa Leu Xaa Pro Cys Leu Pro Xaa Xaa Th #r Ala Xaa Pro Xaa Arg 65                   #70                   #75                   #80 Xaa Pro Ile Xaa Xaa Xaa Xaa Gly Asp Trp Xa #a Glu Phe Xaa Xaa Lys                 85   #                90   #                95 Leu Xaa Phe Tyr Leu Xaa Xaa Leu Glu Xaa Xa #a Xaa Xaa Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 7:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 133 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- may or may not precede                the amino # acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Asn                or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 19           (D) OTHER INFORMATION:  #/note= “Xaa at position 19 is Met,                Ala, or  #Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 20           (D) OTHER INFORMATION:  #/note= “Xaa at position 20 is Ile,                Pro, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Ile,                Ala, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 25           (D) OTHER INFORMATION:  #/note= “Xaa at position 25 is Thr                or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 29           (D) OTHER INFORMATION:  #/note= “Xaa at position 29 is Gln,                Arg, Val, # or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Leu,                Ala, Asn, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 34           (D) OTHER INFORMATION:  #/note= “Xaa at position 34 is Leu                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Phe,                Pro, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION:(B) LOCATION; # 38           (D) OTHER INFORMATION:  #/note= “Xaa at position 38 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Gly,                Ala, Ser, # Asp, or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 45           (D) OTHER INFORMATION:  #/note= “Xaa at position 45 is Gln,                Val, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Asp                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 49           (D) OTHER INFORMATION:  #/note= “Xaa at position 49 is Met,                Ile, Leu, # or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 50           (D) OTHER INFORMATION:  #/note= “Xaa at position 50 is Glu                or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Asn,                Arg, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Arg,                Leu, or  #Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 56           (D) OTHER INFORMATION:  #/note= “Xaa at position 56 is Pro                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 59           (D) OTHER INFORMATION:  #/note= “Xaa at position 59 is Glu                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 60           (D) OTHER INFORMATION:  #/note= “Xaa at position 60 is Ala                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Asn                Val, or  #Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 63           (D) OTHER INFORMATION:  #/note= “Xaa at position 63 is Arg                or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Val                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 67           (D) OTHER INFORMATION:  #/note= “Xaa at position 67 is Ser,                Asn, His, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 69           (D) OTHER INFORMATION:  #/note= “Xaa at position 69 is Gln                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Ala                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 76           (D) OTHER INFORMATION:  #/note= “Xaa at position 76 is Ser,                Ala, or  #Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Lys,                Arg, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 82           (D) OTHER INFORMATION:  #/note= “Xaa at position 82 is Leu,                Glu, Val, # or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 85           (D) OTHER INFORMATION:  #/note= “Xaa at position 85 is Leu                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Leu,                Ser, or  #Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 88           (D) OTHER INFORMATION:  #/note= “Xaa at position 88 is Ala                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is Ala                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 93           (D) OTHER INFORMATION:  #/note= “Xaa at position 93 is Pro                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is His                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is His,                Ile, or  #Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 100           (D) OTHER INFORMATION:  #/note= “Xaa at position 100 is Lys                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 101           (D) OTHER INFORMATION:  #/note= “Xaa at position 101 is Asp,                Ala, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 105           (D) OTHER INFORMATION:  #/note= “Xaa at position 105 is Asn                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Arg,                Glu, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 112           (D) OTHER INFORMATION:  #/note= “Xaa at position 112 is Thr                or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 116           (D) OTHER INFORMATION:  #/note= “Xaa at position 116 is Lys,                Val, Trp, # or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 117           (D) OTHER INFORMATION:  #/note= “Xaa at position 117 is Thr                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 120           (D) OTHER INFORMATION:  #/note= “Xaa at position 120 is Asn,                Gln, or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 123           (D) OTHER INFORMATION:  #/note= “Xaa at position 123 is Ala                or Glu”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #7: Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Th #r Ser Trp Val Asn Cya 1               5    #                10   #                15 Ser Xaa Xaa Xaa Asp Glu Xaa Ile Xaa His Le #u Lys Xaa Pro Pro Xaa             20       #            25       #            30 Pro Xaa Leu Asp Xaa Xaa Asn Leu Asn Xaa Gl #u Asp Xaa Xaa Ile Leu         35           #        40           #        45 Xaa Xaa Xaa Asn Leu Arg Xaa Xaa Asn Leu Xa #a Xaa Phe Xaa Xaa Ala     50               #    55               #    60 Xaa Lys Xaa Leu Xaa Asn Ala Ser Xaa Ile Gl #u Xaa Ile Leu Xaa Asn 65                   #70                   #75                   #80 Leu Xaa Pro Cys Xaa Pro Xaa Xaa Thr Ala Xa #a Pro Xaa Arg Xaa Pro                 85   #                90   #                95 Ile Xaa Ile Xaa Xaa Gly Asp Trp Xaa Glu Ph #e Arg Xaa Lys Leu Xaa             100       #           105       #           110 Phe Tyr Leu Xaa Xaa Leu Glu Xaa Ala Gln Xa #a Gln Gln Thr Thr Leu         115           #       120           #       125 Ser Leu Ala Ile Phe     130 (2) INFORMATION FOR SEQ ID NO: 8:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 1           (D) OTHER INFORMATION:  #/note= “Met- or Met-Ala may or may                not prece #de the amino acid in position 1”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 4           (D) OTHER INFORMATION:  #/note= “Xaa at position 4 is Asn or                Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 5           (D) OTHER INFORMATION:  #/note= “Xaa at position 5 is Met,                Ala, or  #Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 6           (D) OTHER INFORMATION:  #/note= “Xaa at position 6 is Ile,                Pro, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 9           (D) OTHER INFORMATION:  #/note= “Xaa at position 9 is Ile,                Ala, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 11           (D) OTHER INFORMATION:  #/note= “Xaa at position 11 is Thr                or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 15           (D) OTHER INFORMATION:  #/note= “Xaa at position 15 is Gln,                Arg, Val, # or Ile”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 18           (D) OTHER INFORMATION:  #/note= “Xaa at position 18 is Leu,                Ala, Asn, # or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 20           (D) OTHER INFORMATION:  #/note= “Xaa at position 20 is Leu                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 23           (D) OTHER INFORMATION:  #/note= “Xaa at position 23 is Phe,                Pro, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 24           (D) OTHER INFORMATION:  #/note= “Xaa at position 24 is Asn                or Ala”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 28           (D) OTHER INFORMATION:  #/note= “Xaa at position 28 is Gly,                Ala, Ser, # Asp, or Asn”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 31           (D) OTHER INFORMATION:  #/note= “Xaa at position 31 is Gln,                Val, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 32           (D) OTHER INFORMATION:  #/note= “Xaa at position 32 is Asp                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 35           (D) OTHER INFORMATION:  #/note= “Xaa at position 35 is Met,                Ile, or  #Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION:(B) LOCATION  #36           (D) OTHER INFORMATION:  #/note= “Xaa at position 36 is Glu                or Asp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 37           (D) OTHER INFORMATION:  #/note= “Xaa at position 37 is Asn,                Arg, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 41           (D) OTHER INFORMATION:  #/note= “Xaa at position 41 is Arg,                Leu, or  #Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION:(B) LOCATION  #42           (D) OTHER INFORMATION:  #/note= “Xaa at position 42 is Pro                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 45           (D) OTHER INFORMATION:  #/note= “Xaa at position 45 is Glu                or Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 46           (D) OTHER INFORMATION:  #/note= “Xaa at position 46 is Ala                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 48           (D) OTHER INFORMATION:  #/note= “Xaa at position 48 is Asn,                Val, or  #Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 49           (D) OTHER INFORMATION:  #/note= “Xaa at position 49 is Arg                or His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 51           (D) OTHER INFORMATION:  #/note= “Xaa at position 51 is Val                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 53           (D) OTHER INFORMATION:  #/note= “Xaa at position 53 is Ser,                Asn, His, # or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 55           (D) OTHER INFORMATION:  #/note= “Xaa at position 55 is Gln                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 59           (D) OTHER INFORMATION:  #/note= “Xaa at position 59 is Ala                or Gly”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 62           (D) OTHER INFORMATION:  #/note= “Xaa at position 62 is Ser,                Ala, or  #Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 65           (D) OTHER INFORMATION:  #/note= “Xaa at position 65 is Lys,                Arg, or  #Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 67           (D) OTHER INFORMATION:  #/note= “Xaa at position 67 is Leu,                Glu, or  #Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 68           (D) OTHER INFORMATION:  #/note= “Xaa at position 68 is Leu,                Glu, Val, # or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION:(B) LOCATION  #71           (D) OTHER INFORMATION:  #/note= “Xaa at position 71 is Leu                or Val”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 73           (D) OTHER INFORMATION:  #/note= “Xaa at position 73 is Leu,                Ser, or  #Tyr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 74           (D) OTHER INFORMATION:  #/note= “Xaa at position 74 is Ala                or Trp”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 77           (D) OTHER INFORMATION:  #/note= “Xaa at position 77 is Ala                or Pro”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 79           (D) OTHER INFORMATION:  #/note= “Xaa at position 79 is Pro                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 81           (D) OTHER INFORMATION:  #/note= “Xaa at position 81 is His                or Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 84           (D) OTHER INFORMATION:  #/note= “Xaa at position 84 is His,                Ile, or  #Thr”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 86           (D) OTHER INFORMATION:  #/note= “Xaa at position 86 is Lys                or Arg”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 87           (D) OTHER INFORMATION:  #/note= “Xaa at position 87 is Asp,                Ala, or  #Met”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 91           (D) OTHER INFORMATION:  #/note= “Xaa at position 91 is Asn                or Glu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 95           (D) OTHER INFORMATION:  #/note= “Xaa at position 95 is Arg,                Glu, or  #Leu”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 98           (D) OTHER INFORMATION:  #/note= “Xaa at position 98 is Thr                or Gln”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 102           (D) OTHER INFORMATION:  #/note= “Xaa at position 102 is Lys,                Val, Trp, # or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 103           (D) OTHER INFORMATION:  #/note= “Xaa at position 103 is Thr                or Ser”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 106           (D) OTHER INFORMATION:  #/note= “Xaa at position 106 is Asn,                Gln, or  #His”     (ix) FEATURE:           (A) NAME/KEY: Modified-sit #e           (B) LOCATION: 109           (D) OTHER INFORMATION:  #/note= “Xaa at position 109 is Ala                or Glu”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #8: Asn Cys Ser Xaa Xaa Xaa Asp Glu Xaa Ile Xa #a His Leu Lys Xaa Pro 1               5    #                10   #                15 Pro Xaa Pro Xaa Leu Asp Xaa Xaa Asn Leu As #n Xaa Glu Asp Xaa Xaa             20       #            25       #            30 Ile Leu Xaa Xaa Xaa Asn Leu Arg Xaa Xaa As #n Leu Xaa Xaa Phe Xaa         35           #        40           #        45 Xaa Ala Xaa Lys Xaa Leu Xaa Asn Ala Ser Xa #a Ile Glu Xaa Ile Leu     50               #    55               #    60 Xaa Asn Xaa Xaa Pro Cys Xaa Pro Xaa Xaa Th #r Ala Xaa Pro Xaa Arg 65                   #70                   #75                   #80 Xaa Pro Ile Xaa Ile Xaa Xaa Gly Asp Trp Xa #a Glu Phe Arg Xaa Lys                 85   #                90   #                95 Leu Xaa Phe Tyr Leu Xaa Xaa Leu Glu Xaa Al #a Gln Xaa Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 9:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #9: Asn Cys Ser Ile Met Ile Asp Glu Ile Ile Hi #s His Leu Lys Arg Pro 1               5    #                10   #                15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu As #n Ala Glu Asp Val Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 10:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #10: Asn Cys Ser Ile Met Ile Asp Glu Ile Ile Hi #s His Leu Lys Arg Pro 1               5    #                10   #                15 Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu As #n Ser Glu Asp Met Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 11:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #11: Asn Cys Ser Ile Met Ile Asp Glu Ile Ile Hi #s His Leu Lys Val Pro 1               5    #                10   #                15 Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu As #n Ser Glu Asp Met Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 12:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #12: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Arg Asn Leu Arg Leu Pro As #n Leu Leu Ala Phe Val         35           #        40           #        45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 13:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #13: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Arg Asn Leu Arg Leu Pro As #n Leu Glu Ser Phe Val         35           #        40           #        45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 14:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #14: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Arg Asn Leu Arg Thr Pro As #n Leu Leu Ala Phe Val         35           #        40           #        45 Arg Ala Val Lys His Leu Glu Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 15:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #15: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gl #y Ile Glu Ala Ile Leu     50               #    55               #    60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Th #r Ala Ala Pro Ser Arg 65                   #70                   #75                   #80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gl #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 16:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #16: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gl #y Ile Glu Ala Ile Leu     50               #    55               #    60 Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Th #r Ala Ala Pro Ser Arg 65                   #70                   #75                   #80 His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gl #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 17:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #17: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Glu Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Al #a Gln Glu Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 18:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #18: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Glu Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Val Ser Leu Glu His Al #a Gln Glu Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 19:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #19: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gl #y Ile Glu Ala Ile Leu     50               #    55               #    60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Th #r Ala Ala Pro Ser Arg 65                   #70                   #75                   #80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gl #n Glu Phe Arg Glu Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Al #a Gln Glu Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 20:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #20: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gl #y Ile Glu Ala Ile Leu     50               #    55               #    60 Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Th #r Ala Ala Pro Ser Arg 65                   #70                   #75                   #80 His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gl #n Glu Phe Arg Glu Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Al #a Gln Glu Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 21:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #21: Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Th #r His Leu Lys Gln Pro 1               5    #                10   #                15 Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu As #n Gly Glu Asp Gln Asp             20       #            25       #            30 Ile Leu Met Glu Asn Asn Leu Arg Arg Pro As #n Leu Glu Ala Phe Asn         35           #        40           #        45 Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gl #y Ile Glu Ala Ile Leu     50               #    55               #    60 Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Th #r Ala Ala Pro Ser Arg 65                   #70                   #75                   #80 His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gl #n Glu Phe Arg Glu Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Val Ser Leu Glu His Al #a Gln Glu Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 22:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #22: Asn Cys Ser Ile Met Ile Asp Glu Ile Ile Hi #s His Leu Lys Arg Pro 1               5    #                10   #                15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu As #n Ala Glu Asp Val Asp             20       #            25       #            30 Ile Leu Met Glu Arg Asn Leu Arg Leu Pro As #n Leu Glu Ser Phe Val         35           #        40           #        45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 23:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #23: Asn Cys Ser Ile Met Ile Asp Glu Ile Ile Hi #s His Leu Lys Arg Pro 1               5    #                10   #                15 Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu As #n Ser Glu Asp Met Asp             20       #            25       #            30 Ile Leu Met Glu Arg Asn Leu Arg Thr Pro As #n Leu Leu Ala Phe Val         35           #        40           #        45 Arg Ala Val Lys His Leu Glu Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 24:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 111 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #24: Asn Cys Ser Ile Met Ile Asp Glu Ile Ile Hi #s His Leu Lys Val Pro 1               5    #                10   #                15 Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu As #n Ser Glu Asp Met Asp             20       #            25       #            30 Ile Leu Met Glu Arg Asn Leu Arg Leu Pro As #n Leu Leu Ala Phe Val         35           #        40           #        45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Al #a Ile Glu Ser Ile Leu     50               #    55               #    60 Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Th #r Ala Ala Pro Thr Arg 65                   #70                   #75                   #80 His Pro Ile His Ile Lys Asp Gly Asp Trp As #n Glu Phe Arg Arg Lys                 85   #                90   #                95 Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Al #a Gln Ala Gln Gln             100       #           105       #           110 (2) INFORMATION FOR SEQ ID NO: 25:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #25: Met Ala Asn Cys Ser Asn Met Ile Asp Glu Il #e Ile Thr His Leu Lys 1               5    #                10   #                15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn As #n Leu Asn Gly Glu Asp             20       #            25       #            30 Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Ar #g Pro Asn Leu Glu Ala         35           #        40           #        45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln            100        #          105        #          110 Gln (2) INFORMATION FOR SEQ ID NO: 26:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide         (xi) SEQUENCE DESCRIPTION: SEQ  #ID NO: 26: Met Ala Asn Cys Ser Asn Met Ile Asp Glu Il #e Ile Thr His Leu Lys 1               5    #                10   #                15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn As #n Leu Asn Gly Glu Asp             20       #            25       #            30 Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Ar #g Pro Asn Leu Glu Ala         35           #        40           #        45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 27:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #27: Met Ala Asn Cys Ser Asn Met Ile Asp Glu Il #e Ile Thr His Leu Lys 1               5    #                10   #                15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn As #n Leu Asn Gly Glu Asp             20       #            25       #            30 Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Ar #g Pro Asn Leu Glu Ala         35           #        40           #        45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Gl #u His Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 28:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #28: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Ly 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Ala Glu As             20       #            25       #            30 Val Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Se         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Ala Ile Glu Se     50               #    55               #    60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Le #u Ala Thr Ala Ala Pr 65                   #70                   #75                   #80 Thr Arg His Pro Ile His Ile Lys Asp Gly As #p Trp Asn Glu Phe Ar                 85   #                90   #                95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Gl #u Asn Ala Gln Ala Gl             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 29:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #29: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Ala Ile Glu Ser     50               #    55               #    60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Le #u Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Thr Arg His Pro Ile His Ile Lys Asp Gly As #p Trp Asn Glu Phe Arg                 85   #                90   #                95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Gl #u Asn Ala Gln Ala Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 30:      (i) SEQUENCE CHARACTERISTICS:s           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #30: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Ly 1               5    #                10   #                15 Val Pro Pro Ala Pro Leu Leu Asp Ser Asn As #n Leu Asn Ser Glu As             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Leu Al         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Ala Ile Glu Se     50               #    55               #    60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Le #u Ala Thr Ala Ala Pr 65                   #70                   #75                   #80 Thr Arg His Pro Ile His Ile Lys Asp Gly As #p Trp Asn Glu Phe Ar                 85   #                90   #                95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Gl #u Asn Ala Gln Ala Gl             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 31:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #31: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Ala Glu Asp             20       #            25       #            30 Val Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 32:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide         (xi) SEQUENCE DESCRIPTION: SEQ  #ID NO: 32: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 33:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #33: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Val Pro Pro Ala Pro Leu Leu Asp Ser Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 34:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #34: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Ala Glu Asp             20       #            25       #            30 Val Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 35:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #35: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Val Pro Pro Ala Pro Leu Leu Asp Ser Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 36:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #36: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Gl #u His Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 37:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #37: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Val Pro Pro Ala Pro Leu Leu Asp Ser Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Gl #u His Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 38:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #38: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 39:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #39: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Ala Glu Asp             20       #            25       #            30 Val Asp Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Thr Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Gl #u His Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 40:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #40: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Ala Glu Asp             20       #            25       #            30 Val Asp Ile Leu Met Asp Arg Asn Leu Arg Le #u Ser Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 41:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #41: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Al #a Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Ser Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Met Ser Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 42:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #42: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Met Ser Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 43:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #43: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Ala Glu Asp             20       #            25       #            30 Val Asp Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 44:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #44: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 45:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #45: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Met Ser Ile Leu Met Glu Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 46:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 125 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #46: Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp As #p Asp Asp Lys Asn Cys 1               5    #                10   #                15 Ser Ile Met Ile Asp Glu Ile Ile His His Le #u Lys Arg Pro Pro Ala             20       #            25       #            30 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Gl #u Asp Val Asp Ile Leu         35           #        40           #        45 Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Gl #u Ser Phe Val Arg Ala     50               #    55               #    60 Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Gl #u Ala Ile Leu Arg Asn 65                   #70                   #75                   #80 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Al #a Pro Ser Arg His Pro                 85   #                90   #                95 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Ph #e Arg Glu Lys Leu Thr             100       #           105       #           110 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Gl #u Gln Gln         115           #       120           #       125 (2) INFORMATION FOR SEQ ID NO: 47:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 125 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #47: Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp As #p Asp Asp Lys Asn Cys 1               5    #                10   #                15 Ser Ile Met Ile Asp Glu Ile Ile His His Le #u Lys Arg Pro Pro Asn             20       #            25       #            30 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Gl #u Asp Met Asp Ile Leu         35           #        40           #        45 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Le #u Ala Phe Val Arg Ala     50               #    55               #    60 Val Lys His Leu Glu Asn Ala Ser Gly Ile Gl #u Ala Ile Leu Arg Asp 65                   #70                   #75                   #80 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Al #a Pro Ser Arg His Pro                 85   #                90   #                95 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Ph #e Arg Glu Lys Leu Thr             100       #           105       #           110 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Gl #u Gln Gln         115           #       120           #       125 (2) INFORMATION FOR SEQ ID NO: 48:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 113 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #48: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Le #u Ile His His Leu Lys 1               5    #                10   #                15 Ile Pro Pro Asn Pro Ser Leu Asp Ser Ala As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln (2) INFORMATION FOR SEQ ID NO: 49:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 134 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #49: Met Ala Pro Met Thr Gln Thr Thr Ser Leu Ly #s Thr Ser Trp Val Asn 1               5    #                10   #                15 Cys Ser Asn Met Ile Asp Glu Ile Ile Thr Hi #s Leu Lys Gln Pro Pro             20       #            25       #            30 Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gl #y Glu Asp Gln Asp Ile         35           #        40           #        45 Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Le #u Glu Ala Phe Asn Arg     50               #    55               #    60 Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Il #e Glu Ser Ile Leu Lys 65                   #70                   #75                   #80 Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Al #a Ala Pro Thr Arg His 85                   #90 95 Pro Ile His Ile Lys Asp Gly Asp Trp Asn Gl #u Phe Arg Arg Lys Leu             100       #           105       #           110 Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gl #n Ala Gln Gln Thr Thr         115           #       120           #       125 Leu Ser Leu Ala Ile Phe     130 (2) INFORMATION FOR SEQ ID NO: 50:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 36 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #50: Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gl #y Ser Glu Gly Gly Gly 1               5    #                10   #                15 Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Se #r Glu Gly Gly Gly Ser             20       #            25       #            30 Gly Gly Gly Ser         35 (2) INFORMATION FOR SEQ ID NO: 51:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 24 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #51: Ile Ser Glu Pro Ser Gly Pro Ile Ser Thr Il #e Asn Pro Ser Pro Pro 1               5    #                10   #                15 Ser Lys Glu Ser His Lys Ser Pro             20 (2) INFORMATION FOR SEQ ID NO: 52:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 28 amino  #acids           (B) TYPE: amino acid           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #52: Ile Glu Gly Arg Ile Ser Glu Pro Ser Gly Pr #o Ile Ser Thr Ile Asn 1               5    #                10   #                15 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Se #r Pro             20       #            25 (2) INFORMATION FOR SEQ ID NO: 53:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 906 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #53: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTAGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTGC TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TAACTGGGAA TGGCCCCTGC CC #TGCAGCCC    780 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AG #GGGTCCTG    840 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CC #ACCTTGCG    900 CAGCCC                  #                   #                   #          906 (2) INFORMATION FOR SEQ ID NO: 54:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 732 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #54: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA ACTGCTCTAT AA #TGATCGAT    420 GAAATTATAC ATCACTTAAA GAGACCACCT AACCCTTTGC TGGACCCGAA CA #ACCTCAAT    480 TCTGAAGACA TGGATATCCT GATGGAACGA AACCTTCGAA CTCCAAACCT GC #TCGCATTC    540 GTAAGGGCTG TCAAGCACTT AGAAAATGCA TCAGGTATTG AGGCAATTCT TC #GTAATCTC    600 CAACCATGTC TGCCCTCTGC CACGGCCGCA CCCTCTCGAC ATCCAATCAT CA #TCAAGGCA    660 GGTGACTGGC AAGAATTCCG GGAAAAACTG ACGTTCTATC TGGTTACCCT TG #AGCAAGCG    720 CAGGAACAAC AG               #                   #                   #      732 (2) INFORMATION FOR SEQ ID NO: 55:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 777 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #55: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCAC CGGCTCGTTC CC #CGTCCCCG    420 TCTACCCAGC CGTGGGAACA CGTGAATGCC ATCCAGGAGG CCCGGCGTCT CC #TGAACCTG    480 AGTAGAGACA CTGCTGCTGA GATGAATGAA ACAGTAGAAG TGATATCAGA AA #TGTTTGAC    540 CTCCAGGAGC CGACTTGCCT ACAGACCCGC CTGGAGCTGT ACAAGCAGGG CC #TGCGGGGC    600 AGCCTCACCA AGCTCAAGGG CCCCTTGACC ATGATGGCCA GCCACTACAA GC #AGCACTGC    660 CCTCCAACCC CGGAAACTTC CTGTGCAACC CAGATTATCA CCTTTGAAAG TT #TCAAAGAG    720 AACCTGAAGG ACTTCCTGCT TGTCATCCCC TTTGACTGCT GGGAGCCAGT CC #AGGAG       777 (2) INFORMATION FOR SEQ ID NO: 56:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #56: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTGGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GG #GAATGGCC    780 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CC #AGCGCCGG    840 GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GT #ACCGCGTT    900 CTACGCCACC TTGCGCAGCC C            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 57:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 951 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #57: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTC CAGTACCACC AG #GTGAAGAT    420 TCCAAAGATG TGGCCGCCCC ACACAGACAG CCACTCACCT CTTCAGAACG AA #TTGACAAA    480 CAAATTCGGT ACATCCTCGA CGGGATATCA GCCCTGAGAA AGGAGACATG TA #ACAAGAGT    540 AACATGTGTG AAAGCAGCAA AGAGGCGCTA GCAGAAAACA ACCTGAACCT TC #CAAAGATG    600 GCTGAAAAAG ATGGATGCTT CCAATCCGGA TTCAATGAGG AGACTTGCCT GG #TGAAAATC    660 ATCACTGGTC TTTTGGAGTT TGAGGTATAC CTCGAGTACC TCCAGAACAG AT #TTGAGAGT    720 AGTGAGGAAC AAGCCAGAGC TGTGCAGATG TCGACAAAAG TCCTGATCCA GT #TCCTGCAG    780 AAAAAGGCAA AGAATCTAGA TGCAATAACC ACCCCTGACC CAACCACAAA TG #CATCCCTG    840 CTGACGAAGC TGCAGGCACA GAACCAGTGG CTGCAGGACA TGACAACTCA TC #TCATTCTG    900 CGCAGCTTTA AGGAGTTCCT GCAGTCCAGC CTGAGGGCTC TTCGGCAAAT G  #            951 (2) INFORMATION FOR SEQ ID NO: 58:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 732 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #58: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAAGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA ACTGCTCTAT AA #TGATCGAT    420 GAAATTATAC ATCACTTAAA GAGACCACCT AACCCTTTGC TGGACCCGAA CA #ACCTCAAT    480 TCTGAAGACA TGGATATCCT GATGGAACGA AACCTTCGAA CTCCAAACCT GC #TCGCATTC    540 GTAAGGGCTG TCAAGCACTT AGAAAATGCA TCAGGTATTG AGGCAATTCT TC #GTAATCTC    600 CAACCATGTC TGCCCTCTGC CACGGCCGCA CCCTCTCGAC ATCCAATCAT CA #TCAAGGCA    660 GGTGACTGGC AAGAATTCCG GGAAAAACTG ACGTTCTATC TGGTTACCCT TG #AGCAAGCG    720 CAGGAACAAC AG               #                   #                   #      732 (2) INFORMATION FOR SEQ ID NO: 59:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #59: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATAC    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAAGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTGGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GG #GAATGGCC    780 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CC #AGCGCCGG    840 GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GT #ACCGCGTT    900 CTACGCCACC TTGCGCAGCC C            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 60:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #60: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTGGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GG #GAATGGCC    780 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CC #AGCGCCGG    840 GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GT #ACCGCGTT    900 CTACGCCACC TTGCGCAGCC C            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 61:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 732 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #61: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATAC    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCA    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA ACTGCTCTAT AA #TGATCGAT    420 GAAATTATAC ATCACTTAAA GAGACCACCT AACCCTTTGC TGGACCCGAA CA #ACCTCAAT    480 TCTGAAGACA TGGATATCCT GATGGAACGA AACCTTCGAA CTCCAAACCT GC #TCGCATTC    540 GTAAGGGCTG TCAAGCACTT AGAAAATGCA TCAGGTATTG AGGCAATTCT TC #GTAATCTC    600 CAACCATGTC TGCCCTCTGC CACGGCCGCA CCCTCTCGAC ATCCAATCAT CA #TCAAGGCA    660 GGTGACTGGC AAGAATTCCG GGAAAAACTG ACGTTCTATC TGGTTACCCT TG #AGCAAGCG    720 CAGGAACAAC AG               #                   #                   #      732 (2) INFORMATION FOR SEQ ID NO: 62:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 777 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #62: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTAACTGC TCTATAATGA TCGATGAAAT TA #TACATCAC    480 TTAAAGAGAC CACCTAACCC TTTGCTGGAC CCGAACAACC TCAATTCTGA AG #ACATGGAT    540 ATCCTGATGG AACGAAACCT TCGAACTCCA AACCTGCTCG CATTCGTAAG GG #CTGTCAAG    600 CACTTAGAAA ATGCATCAGG TATTGAGGCA ATTCTTCGTA ATCTCCAACC AT #GTCTGCCC    660 TCTGCCACGG CCGCACCCTC TCGACATCCA ATCATCATCA AGGCAGGTGA CT #GGCAAGAA    720 TTCCGGGAAA AACTGACGTT CTATCTGGTT ACCCTTGAGC AAGCGCAGGA AC #AACAG       777 (2) INFORMATION FOR SEQ ID NO: 63:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 777 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #63: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAAGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTAACTGC TCTATAATGA TCGATGAAAT TA #TACATCAC    480 TTAAAGAGAC CACCTAACCC TTTGCTGGAC CCGAACAACC TCAATTCTGA AG #ACATGGAT    540 ATCCTGATGG AACGAAACCT TCGAACTCCA AACCTGCTCG CATTCGTAAG GG #CTGTCAAG    600 CACTTAGAAA ATGCATCAGG TATTGAGGCA ATTCTTCGTA ATCTCCAACC AT #GTCTGCCC    660 TCTGCCACGG CCGCACCCTC TCGACATCCA ATCATCATCA AGGCAGGTGA CT #GGCAAGAA    720 TTCCGGGAAA AACTGACGTT CTATCTGGTT ACCCTTGAGC AAGCGCAGGA AC #AACAG       777 (2) INFORMATION FOR SEQ ID NO: 64:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 777 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #64: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTAACTGC TCTATAATGA TCGATGAAAT TA #TACATCAC    480 TTAAAGAGAC CACCTAACCC TTTGCTGGAC CCGAACAACC TCAATTCTGA AG #ACATGGAT    540 ATCCTGATGG AACGAAACCT TCGAACTCCA AACCTGCTCG CATTCGTAAG GG #CTGTCAAG    600 CACTTAGAAA ATGCATCAGG TATTGAGGCA ATTCTTCGTA ATCTCCAACC AT #GTCTGCCC    660 TCTGCCACGG CCGCACCCTC TCGACATCCA ATCATCATCA AGGCAGGTGA CT #GGCAAGAA    720 TTCCGGGAAA AACTGACGTT CTATCTGGTT ACCCTTGAGC AAGCGCAGGA AC #AACAG       777 (2) INFORMATION FOR SEQ ID NO: 65:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 1047 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #65: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCCGGGC CTCCTGTCAA TGCTGGCGGC GGCTCTGGTG GTGGTTCTGG TG #GCGGCTCT    420 GAGGGTGGCG GCTCTGAGGG TGGCGGTTCT GAGGGTGGCG GCTCTGAGGG TG #GCGGTTCC    480 GGTGGCGGCT CCGGTTCCGG TGATTTTGAT TATGAAAACA TGGCTACACC AT #TGGGCCCT    540 GCCAGCTCCC TGCCCCAGAG CTTCCTGCTC AAGTCTTTAG AGCAAGTGAG GA #AGATCCAG    600 GGCGATGGCG CAGCGCTCCA GGAGAAGCTG TGTGCCACCT ACAAGCTGTG CC #ACCCCGAG    660 GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG CTCCCCTGAG CT #CCTGCCCC    720 AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TT #TCCTCTAC    780 CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CT #TGGACACA    840 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AG #AACTGGGA    900 ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG CCTTCGCCTC TG #CTTTCCAG    960 CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC CATCTGCAGA GCTTCCTGGA GG #TGTCGTAC   1020 CGCGTTCTAC GCCACCTTGC GCAGCCC           #                   #           1047 (2) INFORMATION FOR SEQ ID NO: 66:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 903 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #66: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCCGGGC CTCCTGTCAA TGCTGGCGGC GGCTCTGGTG GTGGTTCTGG TG #GCGGCTCT    420 GAGGGTGGCG GCTCTGAGGG TGGCGGTTCT GAGGGTGGCG GCTCTGAGGG TG #GCGGTTCC    480 GGTGGCGGCT CCGGTTCCGG TGATTTTGAT TATGAAAACA TGGCACCGGC TC #GTTCCCCG    540 TCCCCGTCTA CCCAGCCGTG GGAACACGTG AATGCCATCC AGGAGGCCCG GC #GTCTCCTG    600 AACCTGAGTA GAGACACTGC TGCTGAGATG AATGAAACAG TAGAAGTGAT AT #CAGAAATG    660 TTTGACCTCC AGGAGCCGAC TTGCCTACAG ACCCGCCTGG AGCTGTACAA GC #AGGGCCTG    720 CGGGGCAGCC TCACCAAGCT CAAGGGCCCC TTGACCATGA TGGCCAGCCA CT #ACAAGCAG    780 CACTGCCCTC CAACCCCGGA AACTTCCTGT GCAACCCAGA TTATCACCTT TG #AAAGTTTC    840 AAAGAGAACC TGAAGGACTT CCTGCTTGTC ATCCCCTTTG ACTGCTGGGA GC #CAGTCCAG    900 GAG                   #                   #                   #            903 (2) INFORMATION FOR SEQ ID NO: 67:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 1017 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #67: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCCGGTG GCGGCGGCTC TGGTGGTGGT TCTGGTGGCG GCTCTGAGGG TG #GCGGCTCT    420 GAGGGTGGCG GTTCTGAGGG TGGCGGCTCT GAGGGTGGCG GTTCCGGTGG CG #GCTCCGGT    480 TCCGGTAACA TGGCTACACC ATTAGGCCCT GCCAGCTCCC TGCCCCAGAG CT #TCCTGCTC    540 AAGTGCTTAG AGCAAGTGAG GAAGATCCAG GGCGATGGCG CAGCGCTCCA GG #AGAAGCTG    600 TGTGCCACCT ACAAGCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CT #CTCTGGGC    660 ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC AG #GCTGCTTG    720 AGCCAACTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC TGCAGGCCCT GG #AAGGGATA    780 TCCCCCGAGT TGGGTCCCAC CTTGGACACA CTGCAGCTGG ACGTCGCCGA CT #TTGCCACC    840 ACCATCTGGC AGCAGATGGA AGAACTGGGA ATGGCCCCTG CCCTGCAGCC CA #CCCAGGGT    900 GCCATGCCGG CCTTCGCCTC TGCTTTCCAG CGCCGGGCAG GAGGGGTCCT GG #TTGCTAGC    960 CATCTGCAGA GCTTCCTGGA GGTGTCGTAC CGCGTTCTAC GCCACCTTGC GC #AGCCC      1017 (2) INFORMATION FOR SEQ ID NO: 68:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #68: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCC    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTACACCA TTAGGCCCTG CCAGCTCCCT GC #CCCAGAGC    480 TTCCTGCTCA AGTGCTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC AG #CGCTCCAG    540 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GC #TCGGACAC    600 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GC #AGCTGGCA    660 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GC #AGGCCCTG    720 GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CG #TCGCCGAC    780 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC CC #TGCAGCCC    840 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AG #GGGTCCTG    900 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CC #ACCTTGCG    960 CAGCCC                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 69:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 822 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #69: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCACCGGCT CGTTCCCCGT CCCCGTCTAC CC #AGCCGTGG    480 GAACACGTGA ATGCCATCCA GGAGGCCCGG CGTCTCCTGA ACCTGAGTAG AG #ACACTGCT    540 GCTGAGATGA ATGAAACAGT AGAAGTGATA TCAGAAATGT TTGACCTCCA GG #AGCCGACT    600 TGCCTACAGA CCCGCCTGGA GCTGTACAAG CAGGGCCTGC GGGGCAGCCT CA #CCAAGCTC    660 AAGGGCCCCT TGACCATGAT GGCCAGCCAC TACAAGCAGC ACTGCCCTCC AA #CCCCGGAA    720 ACTTCCTGTG CAACCCAGAT TATCACCTTT GAAAGTTTCA AAGAGAACCT GA #AGGACTTC    780 CTGCTTGTCA TCCCCTTTGA CTGCTGGGAG CCAGTCCAGG AG     #                   # 822 (2) INFORMATION FOR SEQ ID NO: 70:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #70: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAAGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTACACCA TTAGGCCCTG CCAGCTCCCT GC #CCCAGAGC    480 TTCCTGCTCA AGTGCTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC AG #CGCTCCAG    540 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GC #TCGGACAC    600 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GC #AGCTGGCA    660 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GC #AGGCCCTG    720 GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CG #TCGCCGAC    780 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC CC #TGCAGCCC    840 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AG #GGGTCCTG    900 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CC #ACCTTGCG    960 CAGCCC                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 71:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #71: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTACACCA TTAGGCCCTG CCAGCTCCCT GC #CCCAGAGC    480 TTCCTGCTCA AGTGCTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC AG #CGCTCCAG    540 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GC #TCGGACAC    600 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GC #AGCTGGCA    660 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GC #AGGCCCTG    720 GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CG #TCGCCGAC    780 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC CC #TGCAGCCC    840 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AG #GGGTCCTG    900 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CC #ACCTTGCG    960 CAGCCC                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 72:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #72: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAATCGAG    540 GGAAGGATTT CCCCGGGTGG TGGTTCTGGC GGCGGCTCCA ACATGGCTAA CT #GCTCTATA    600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GG #ACCCGAAC    660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TC #CAAACCTG    720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GG #CAATTCTT    780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TC #CAATCATC    840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GG #TTACCCTT    900 GAGCAAGCGC AGGAACAACA G            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 73:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #73: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAATCGAG    540 GGAAGGATTT CCCCGGGTGA ACCGTCTGGT CCAATCTCTA CTATCAACCC GT #CTCCTCCG    600 TCTAAAGAAT CTCATAAATC TCCAAACATG GCTAACTGCT CTATAATGAT CG #ATGAAATT    660 ATACATCACT TAAAGAGACC ACCTAACCCT TTGCTGGACC CGAACAACCT CA #ATTCTGAA    720 GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC AT #TCGTAAGG    780 GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TC #TCCAACCA    840 TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GG #CAGGTGAC    900 TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AG #CGCAGGAA    960 CAACAG                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 74:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 1047 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #74: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAATCGAG    540 GGAAGGATTT CCCCCGGGCC TCCTGTCAAT GCTGGCGGCG GCTCTGGTGG TG #GTTCTGGT    600 GGCGGCTCTG AGGGTGGCGG CTCTGAGGGT GGCGGTTCTG AGGGTGGCGG CT #CTGAGGGT    660 GGCGGTTCCG GTGGCGGCTC CGGTTCCGGT GATTTTGATT ATGAAAACAT GG #CTAACTGC    720 TCTATAATGA TCGATGAAAT TATACATCAC TTAAAGAGAC CACCTAACCC TT #TGCTGGAC    780 CCGAACAACC TCAATTCTGA AGACATGGAT ATCCTGATGG AACGAAACCT TC #GAACTCCA    840 AACCTGCTCG CATTCGTAAG GGCTGTCAAG CACTTAGAAA ATGCATCAGG TA #TTGAGGCA    900 ATTCTTCGTA ATCTCCAACC ATGTCTGCCC TCTGCCACGG CCGCACCCTC TC #GACATCCA    960 ATCATCATCA AGGCAGGTGA CTGGCAAGAA TTCCGGGAAA AACTGACGTT CT #ATCTGGTT   1020 ACCCTTGAGC AAGCGCAGGA ACAACAG           #                   #           1047 (2) INFORMATION FOR SEQ ID NO: 75:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #75: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAATCGAG    540 GGAAGGATTT CCCCGGGTGG TGGTTCTGGC GGCGGCTCCA ACATGGCTAA CT #GCTCTATA    600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTG CACCTTTGCT GG #ACCCGAAC    660 AACCTCAATG ACGAAGACGT CTCTATCCTG ATGGAACGAA ACCTTCGACT TC #CAAACCTG    720 GAGAGCTTCG TAAGGGCTGT CAAGAACTTA GAAAATGCAT CAGGTATTGA GG #CAATTCTT    780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TC #CAATCATC    840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GG #TTACCCTT    900 GAGCAAGCGC AGGAACAACA G            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 76:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 1047 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #76: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAATCGAG    540 GGAAGGATTT CCCCCGGGCC TCCTGTCAAT GCTGGCGGCG GCTCTGGTGG TG #GTTCTGGT    600 GGCGGCTCTG AGGGTGGCGG CTCTGAGGGT GGCGGTTCTG AGGGTGGCGG CT #CTGAGGGT    660 GGCGGTTCCG GTGGCGGCTC CGGTTCCGGT GATTTTGATT ATGAAAACAT GG #CTAACTGC    720 TCTATAATGA TCGATGAAAT TATACATCAC TTAAAGAGAC CACCTGCACC TT #TGCTGGAC    780 CCGAACAACC TCAATGACGA AGACGTCTCT ATCCTGATGG AACGAAACCT TC #GACTTCCA    840 AACCTGGAGA GCTTCGTAAG GGCTGTCAAG AACTTAGAAA ATGCATCAGG TA #TTGAGGCA    900 ATTCTTCGTA ATCTCCAACC ATGTCTGCCC TCTGCCACGG CCGCACCCTC TC #GACATCCA    960 ATCATCATCA AGGCAGGTGA CTGGCAAGAA TTCCGGGAAA AACTGACGTT CT #ATCTGGTT   1020 ACCCTTGAGC AAGCGCAGGA ACAACAG           #                   #           1047 (2) INFORMATION FOR SEQ ID NO: 77:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #77: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAATCGAG    540 GGAAGGATTT CCCCGGGTGA ACCGTCTGGT CCAATCTCTA CTATCAACCC GT #CTCCTCCG    600 TCTAAAGAAT CTCATAAATC TCCAAACATG GCTAACTGCT CTATAATGAT CG #ATGAAATT    660 ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC CGAACAACCT CA #ATGACGAA    720 GACGTCTCTA TCCTGATGGA ACGAAACCTT CGACTTCCAA ACCTGGAGAG CT #TCGTAAGG    780 GCTGTCAAGA ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TC #TCCAACCA    840 TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GG #CAGGTGAC    900 TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AG #CGCAGGAA    960 CAACAG                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 78:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #78: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAGAGGGC    540 GGTGGAGGCT CCCCGGGTGG TGGTTCTGGC GGCGGCTCCA ACATGGCTAA CT #GCTCTATA    600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTG CACCTTTGCT GG #ACCCGAAC    660 AACCTCAATG ACGAAGACGT CTCTATCCTG ATGGAACGAA ACCTTCGACT TC #CAAACCTG    720 GAGAGCTTCG TAAGGGCTGT CAAGAACTTA GAAAATGCAT CAGGTATTGA GG #CAATTCTT    780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TC #CAATCATC    840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GG #TTACCCTT    900 GAGCAAGCGC AGGAACAACA G            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 79:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #79: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAGAGGGC    540 GGTGGAGGCT CCCCGGGTGA ACCGTCTGGT CCAATCTCTA CTATCAACCC GT #CTCCTCCG    600 TCTAAAGAAT CTCATAAATC TCCAAACATG GCTAACTGCT CTATAATGAT CG #ATGAAATT    660 ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC CGAACAACCT CA #ATGACGAA    720 GACGTCTCTA TCCTGATGGA ACGAAACCTT CGACTTCCAA ACCTGGAGAG CT #TCGTAAGG    780 GCTGTCAAGA ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TC #TCCAACCA    840 TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GG #CAGGTGAC    900 TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AG #CGCAGGAA    960 CAACAG                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 80:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #80: ATGGCTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTCTTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAGAGGGC    540 GGTGGAGGCT CCCCGGGTGG TGGTTCTGGC GGCGGCTCCA ACATGGCTAA CT #GCTCTATA    600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTG CACCTTTGCT GG #ACCCGAAC    660 AACCTCAATG ACGAAGACGT CTCTATCCTG ATGGAACGAA ACCTTCGACT TC #CAAACCTG    720 GAGAGCTTCG TAAGGGCTGT CAAGAACTTA GAAAATGCAT CAGGTATTGA GG #CAATTCTT    780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TC #CAATCATC    840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GG #TTACCCTT    900 GAGCAAGCGC AGGAACAACA G            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 81:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #81: ATGGCTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTCTTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTA CG #TAGAGGGC    540 GGTGGAGGCT CCCCGGGTGA ACCGTCTGGT CCAATCTCTA CTATCAACCC GT #CTCCTCCG    600 TCTAAAGAAT CTCATAAATC TCCAAACATG GCTAACTGCT CTATAATGAT CG #ATGAAATT    660 ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC CGAACAACCT CA #ATGACGAA    720 GACGTCTCTA TCCTGATGGA ACGAAACCTT CGACTTCCAA ACCTGGAGAG CT #TCGTAAGG    780 GCTGTCAAGA ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TC #TCCAACCA    840 TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GG #CAGGTGAC    900 TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AG #CGCAGGAA    960 CAACAG                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 82:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 777 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #82: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTAACTGC TCTATAATGA TCGATGAAAT TA #TACATCAC    480 TTAAAGAGAC CACCTGCACC TTTGCTGGAC CCGAACAACC TCAATGACGA AG #ACGTCTCT    540 ATCCTGATGG AACGAAACCT TCGACTTCCA AACCTGGAGA GCTTCGTAAG GG #CTGTCAAG    600 AACTTAGAAA ATGCATCAGG TATTGAGGCA ATTCTTCGTA ATCTCCAACC AT #GTCTGCCC    660 TCTGCCACGG CCGCACCCTC TCGACATCCA ATCATCATCA AGGCAGGTGA CT #GGCAAGAA    720 TTCCGGGAAA AACTGACGTT CTATCTGGTT ACCCTTGAGC AAGCGCAGGA AC #AACAG       777 (2) INFORMATION FOR SEQ ID NO: 83:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 984 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #83: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTACACCA TTGGGCCCTG CCAGCTCCCT GC #CCCAGAGC    480 TTCCTGCTCA AGTCTTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC AG #CGCTCCAG    540 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GC #TCGGACAC    600 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GC #AGCTGGCA    660 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GC #AGGCCCTG    720 GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CG #TCGCCGAC    780 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC CC #TGCAGCCC    840 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AG #GGGTCCTG    900 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CC #ACCTTGCG    960 CAGCCCTGAT AAGGATCCGA ATTC           #                   #               984 (2) INFORMATION FOR SEQ ID NO: 84:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #84: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTAGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTGC TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GG #GAATGGCC    780 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CC #AGCGCCGG    840 GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GT #ACCGCGTT    900 CTACGCCACC TTGCGCAGCC C            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 85:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #85: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTGGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GG #GAATGGCC    780 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CC #AGCGCCGG    840 GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GT #ACCGCGTT    900 CTACGCCACC TTGCGCAGCC C            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 86:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 732 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #86: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA ACTGCTCTAT AA #TGATCGAT    420 GAAATTATAC ATCACTTAAA GAGACCACCT GCACCTTTGC TGGACCCGAA CA #ACCTCAAT    480 GACGAAGACG TCTCTATCCT GATGGAACGA AACCTTCGAC TTCCAAACCT GG #AGAGCTTC    540 GTAAGGGCTG TCAAGAACTT AGAAAATGCA TCAGGTATTG AGGCAATTCT TC #GTAATCTC    600 CAACCATGTC TGCCCTCTGC CACGGCCGCA CCCTCTCGAC ATCCAATCAT CA #TCAAGGCA    660 GGTGACTGGC AAGAATTCCG GGAAAAACTG ACGTTCTATC TGGTTACCCT TG #AGCAAGCG    720 CAGGAACAAC AG               #                   #                   #      732 (2) INFORMATION FOR SEQ ID NO: 87:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 921 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #87: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CACCATTGGG CC #CTGCCAGC    420 TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG TGAGGAAGAT CC #AGGGCGAT    480 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CG #AGGAGCTG    540 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CC #CCAGCCAG    600 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CT #ACCAGGGG    660 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CA #CACTGCAG    720 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GG #GAATGGCC    780 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CC #AGCGCCGG    840 GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GT #ACCGCGTT    900 CTACGCCACC TTGCGCAGCC C            #                   #                 921 (2) INFORMATION FOR SEQ ID NO: 88:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 732 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #88: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA ACTGCTCTAT AA #TGATCGAT    420 GAAATTATAC ATCACTTAAA GAGACCACCT GCACCTTTGC TGGACCCGAA CA #ACCTCAAT    480 GACGAAGACG TCTCTATCCT GATGGAACGA AACCTTCGAC TTCCAAACCT GG #AGAGCTTC    540 GTAAGGGCTG TCAAGAACTT AGAAAATGCA TCAGGTATTG AGGCAATTCT TC #GTAATCTC    600 CAACCATGTC TGCCCTCTGC CACGGCCGCA CCCTCTCGAC ATCCAATCAT CA #TCAAGGCA    660 GGTGACTGGC AAGAATTCCG GGAAAAACTG ACGTTCTATC TGGTTACCCT TG #AGCAAGCG    720 CAGGAACAAC AG               #                   #                   #      732 (2) INFORMATION FOR SEQ ID NO: 89:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 966 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #89: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTACACCA TTGGGCCCTG CCAGCTCCCT GC #CCCAGAGC    480 TTCCTGCTCA AGTCTTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC AG #CGCTCCAG    540 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GC #TCGGACAC    600 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GC #AGCTGGCA    660 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GC #AGGCCCTG    720 GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CG #TCGCCGAC    780 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC CC #TGCAGCCC    840 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AG #GGGTCCTG    900 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CC #ACCTTGCG    960 CAGCCC                  #                   #                   #          966 (2) INFORMATION FOR SEQ ID NO: 90:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 777 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #90: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTGCA     60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GG #AACGAAAC    120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GT #CTAAAGAA    420 TCTCATAAAT CTCCAAACAT GGCTAACTGC TCTATAATGA TCGATGAAAT TA #TACATCAC    480 TTAAAGAGAC CACCTGCACC TTTGCTGGAC CCGAACAACC TCAATGACGA AG #ACGTCTCT    540 ATCCTGATGG AACGAAACCT TCGACTTCCA AACCTGGAGA GCTTCGTAAG GG #CTGTCAAG    600 AACTTAGAAA ATGCATCAGG TATTGAGGCA ATTCTTCGTA ATCTCCAACC AT #GTCTGCCC    660 TCTGCCACGG CCGCACCCTC TCGACATCCA ATCATCATCA AGGCAGGTGA CT #GGCAAGAA    720 TTCCGGGAAA AACTGACGTT CTATCTGGTT ACCCTTGAGC AAGCGCAGGA AC #AACAG       777 (2) INFORMATION FOR SEQ ID NO: 91:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 41 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #91: AATTCCGGGA AAAACTGACG TTCTATCTGG TTACCCTTGA G     #                   #   41 (2) INFORMATION FOR SEQ ID NO: 92:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 46 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #92: CTGCGCTTGC TCAAGGGTAA CCAGATAGAA CGTCAGTTTT TCCCGG    #                 46 (2) INFORMATION FOR SEQ ID NO: 93:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 39 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #93: CAAGCGCAGG AACAACAGTA CGTAATCGAG GGAAGGATT       #                   #    39 (2) INFORMATION FOR SEQ ID NO: 94:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 39 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #94: ACCCGGGGAA ATCCTTCCCT CGATTACGTA CTGTTGTTC       #                   #    39 (2) INFORMATION FOR SEQ ID NO: 95:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 63 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #95: TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGTAAG GTACCGCATG CA #AGCTTAGA     60 TCT                   #                   #                   #             63 (2) INFORMATION FOR SEQ ID NO: 96:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 58 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #96: AGCTAGATCT AAGCTTGCAT GCGGTACCTT ACATGTTGGA GCCGCCGCCA GA #ACCACC       58 (2) INFORMATION FOR SEQ ID NO: 97:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 74 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #97: CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TA #AAGAATCT     60 CATAAATCTC CAAA               #                   #                   #     74 (2) INFORMATION FOR SEQ ID NO: 98:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 74 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #98: CATGTTTGGA GATTTATGAG ATTCTTTAGA CGGAGGAGAC GGGTTGATAG TA #GAGATTGG     60 ACCAGACGGT TCAC               #                   #                   #     74 (2) INFORMATION FOR SEQ ID NO: 99:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 68 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #99: CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CT #TGCGCAGC     60 CCTACGTA                 #                   #                   #          68 (2) INFORMATION FOR SEQ ID NO: 100:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 68 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #100: AGCTTACGTA GGGCTGCGCA AGGTGGCGTA GAACGCGGTA CGACACCTCC AG #GAAGCTCT     60 GCAGATGG                 #                   #                   #          68 (2) INFORMATION FOR SEQ ID NO: 101:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 21 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #101: GTAATCGAGG GAAAGATTTC C            #                   #                   #21 (2) INFORMATION FOR SEQ ID NO: 102:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 25 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #102: CCGGGGAAAT CTTTCCCTCG ATTAC           #                   #               25 (2) INFORMATION FOR SEQ ID NO: 103:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 21 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #103: GTAGAGGGCG GTGGAGGCTC C            #                   #                   #21 (2) INFORMATION FOR SEQ ID NO: 104:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 25 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #104: CCGGGGAGCC TCCACCGCCC TCTAC           #                   #               25 (2) INFORMATION FOR SEQ ID NO: 105:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 58 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “sythetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #105: CATGGCACCA GCAAGATCAC CATCACCATC AACTCAACCT TGGGAACATG TG #AATGCC       58 (2) INFORMATION FOR SEQ ID NO: 106:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 52 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #106: CATTCACATG TTCCCAAGGT TGAGTTGATG GTGATGGTGA TCTTGCTGGT GC #             52 (2) INFORMATION FOR SEQ ID NO: 107:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 66 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #107: CTGCCAGCTC CCTGCCCCAG AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG AG #GAAGATCC     60 AGGGCG                  #                   #                   #           66 (2) INFORMATION FOR SEQ ID NO: 108:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 66 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #108: CTGGATCTTC CTCACTTGCT CTAAAGACTT GAGCAGGAAG CTCTGGGGCA GG #GAGCTGGC     60 AGGGCC                  #                   #                   #           66 (2) INFORMATION FOR SEQ ID NO: 109:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 48 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #109: AGCTTACCTG CCATGGCTCC AGTACCACCA GGTGAAGATT CCAAAGAT   #                48 (2) INFORMATION FOR SEQ ID NO: 110:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 40 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #110: TTGGAATCTT CACCTGGTGG TACTGGAGCC ATGGCAGGTA      #                   #    40 (2) INFORMATION FOR SEQ ID NO: 111:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 26 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #111: AGCTTCCATG GCTACCCCCC TGGGCC           #                   #              26 (2) INFORMATION FOR SEQ ID NO: 112:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 18 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #112: CAGGGGGGTA GCCATGGA              #                   #                   #  18 (2) INFORMATION FOR SEQ ID NO: 113:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 20 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #113: CATGGCTACA CCATTGGGCC             #                   #                   # 20 (2) INFORMATION FOR SEQ ID NO: 114:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 12 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #114: CAATGGTGTA GC               #                   #                   #       12 (2) INFORMATION FOR SEQ ID NO: 115:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 20 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #115: CATGGCTACA CCATTAGGAC             #                   #                   # 20 (2) INFORMATION FOR SEQ ID NO: 116:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 12 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #116: TAATGGTGTA GC               #                   #                   #       12 (2) INFORMATION FOR SEQ ID NO: 117:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 30 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #117: CCTGTCAACC CGGGCGGCGG CTCTGGTGGT          #                   #           30 (2) INFORMATION FOR SEQ ID NO: 118:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 31 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #118: TCATAATACA TGTTACCGGA ACGGAGCCGC C         #                   #          31 (2) INFORMATION FOR SEQ ID NO: 119:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 34 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #119: ATCGTCTGAC CTCCCGGGAC CTCCTGTCAA TGCT        #                   #        34 (2) INFORMATION FOR SEQ ID NO: 120:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 30 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #120: AGCGTTTGAC ATGTTTTCAT AATCAAAATC          #                   #           30 (2) INFORMATION FOR SEQ ID NO: 121:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #121: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Glu                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 122:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #122: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Glu                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 123:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #123: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Lys Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Glu                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 124:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #124: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Gly                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 125:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 244 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #125: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Asn Cys Ser Ile Met Il #e Asp Glu Ile Ile His     130               #   135               #   140 His Leu Lys Arg Pro Pro Asn Pro Leu Leu As #p Pro Asn Asn Leu Asn 145                 1 #50                 1 #55                 1 #60 Ser Glu Asp Met Asp Ile Leu Met Glu Arg As #n Leu Arg Thr Pro Asn                 165   #               170   #               175 Leu Leu Ala Phe Val Arg Ala Val Lys His Le #u Glu Asn Ala Ser Gly             180       #           185       #           190 Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cy #s Leu Pro Ser Ala Thr         195           #       200           #       205 Ala Ala Pro Ser Arg His Pro Ile Ile Ile Ly #s Ala Gly Asp Trp Gln     210               #   215               #   220 Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Va #l Thr Leu Glu Gln Ala 225                 2 #30                 2 #35                 2 #40 Gln Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 126:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 244 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #126: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Lys Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Asn Cys Ser Ile Met Il #e Asp Glu Ile Ile His     130               #   135               #   140 His Leu Lys Arg Pro Pro Asn Pro Leu Leu As #p Pro Asn Asn Leu Asn 145                 1 #50                 1 #55                 1 #60 Ser Glu Asp Met Asp Ile Leu Met Glu Arg As #n Leu Arg Thr Pro Asn                 165   #               170   #               175 Leu Leu Ala Phe Val Arg Ala Val Lys His Le #u Glu Asn Ala Ser Gly             180       #           185       #           190 Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cy #s Leu Pro Ser Ala Thr         195           #       200           #       205 Ala Ala Pro Ser Arg His Pro Ile Ile Ile Ly #s Ala Gly Asp Trp Gln     210               #   215               #   220 Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Va #l Thr Leu Glu Gln Ala 225                 2 #30                 2 #35                 2 #40 Gln Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 127:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 244 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #127: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Asn Cys Ser Ile Met Il #e Asp Glu Ile Ile His     130               #   135               #   140 His Leu Lys Arg Pro Pro Asn Pro Leu Leu As #p Pro Asn Asn Leu Asn 145                 1 #50                 1 #55                 1 #60 Ser Glu Asp Met Asp Ile Leu Met Glu Arg As #n Leu Arg Thr Pro Asn                 165   #               170   #               175 Leu Leu Ala Phe Val Arg Ala Val Lys His Le #u Glu Asn Ala Ser Gly             180       #           185       #           190 Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cy #s Leu Pro Ser Ala Thr         195           #       200           #       205 Ala Ala Pro Ser Arg His Pro Ile Ile Ile Ly #s Ala Gly Asp Trp Gln     210               #   215               #   220 Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Va #l Thr Leu Glu Gln Ala 225                 2 #30                 2 #35                 2 #40 Gln Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 128:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #128: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Se #r Ser Leu Pro Gln Ser 145                 1 #50                 1 #55                 1 #60 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Ly #s Ile Gln Gly Asp Gln                 165   #               170   #               175 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Ty #r Lys Leu Cys His Pro             180       #           185       #           190 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gl #y Ile Pro Trp Ala Pro         195           #       200           #       205 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Le #u Ala Gly Cys Leu Ser     210               #   215               #   220 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gl #y Leu Leu Gln Ala Leu 225                 2 #30                 2 #35                 2 #40 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Le #u Asp Thr Leu Gln Leu                 245   #               250   #               255 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gl #n Gln Met Glu Glu Leu             260       #           265       #           270 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gl #y Ala Met Pro Ala Phe         275           #       280           #       285 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Va #l Leu Val Ala Ser His     290               #   295               #   300 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Va #l Leu Arg His Leu Ala 305                 3 #10                 3 #15                 3 #20 Gln Pro (2) INFORMATION FOR SEQ ID NO: 129:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #129: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Lys Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Se #r Ser Leu Pro Gln Ser 145                 1 #50                 1 #55                 1 #60 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Ly #s Ile Gln Gly Asp Gly                 165   #               170   #               175 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Ty #r Lys Leu Cys His Pro             180       #           185       #           190 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gl #y Ile Pro Trp Ala Pro         195           #       200           #       205 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Le #u Ala Gly Cys Leu Ser     210               #   215               #   220 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gl #y Leu Leu Gln Ala Leu 225                 2 #30                 2 #35                 2 #40 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Le #u Asp Thr Leu Gln Leu                 245   #               250   #               255 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gl #n Gln Met Glu Glu Leu             260       #           265       #           270 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gl #y Ala Met Pro Ala Phe         275           #       280           #       285 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Va #l Leu Val Ala Ser His     290               #   295               #   300 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Va #l Leu Arg His Leu Ala 305                 3 #10                 3 #15                 3 #20 Gln Pro (2) INFORMATION FOR SEQ ID NO: 130:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #130: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Se #r Ser Leu Pro Gln Ser 145                 1 #50                 1 #55                 1 #60 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Ly #s Ile Gln Gly Asp Gly                 165   #               170   #               175 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Ty #r Lys Leu Cys His Pro             180       #           185       #           190 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gl #y Ile Pro Trp Ala Pro         195           #       200           #       205 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Le #u Ala Gly Cys Leu Ser     210               #   215               #   220 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gl #y Leu Leu Gln Ala Leu 225                 2 #30                 2 #35                 2 #40 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Le #u Asp Thr Leu Gln Leu                 245   #               250   #               255 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gl #n Gln Met Glu Glu Leu             260       #           265       #           270 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gl #y Ala Met Pro Ala Phe         275           #       280           #       285 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Va #l Leu Val Ala Ser His     290               #   295               #   300 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Va #l Leu Arg His Leu Ala 305                 3 #10                 3 #15                 3 #20 Gln Pro (2) INFORMATION FOR SEQ ID NO: 131:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 259 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #131: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His 145                 1 #50                 1 #55                 1 #60 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Ser                 165   #               170   #               175 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Le #u Arg Thr Pro Asn Leu             180       #           185       #           190 Leu Ala Phe Val Arg Ala Val Lys His Leu Gl #u Asn Ala Ser Gly Ile         195           #       200           #       205 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala     210               #   215               #   220 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu 225                 2 #30                 2 #35                 2 #40 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Glu                 245   #               250   #               255 Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 132:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 259 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #132: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Lys Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His 145                 1 #50                 1 #55                 1 #60 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Ser                 165   #               170   #               175 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Le #u Arg Thr Pro Asn Leu             180       #           185       #           190 Leu Ala Phe Val Arg Ala Val Lys His Leu Gl #u Asn Ala Ser Gly Ile         195           #       200           #       205 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala     210               #   215               #   220 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu 225                 2 #30                 2 #35                 2 #40 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln                 245   #               250   #               255 Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 133:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 259 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #133: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His 145                 1 #50                 1 #55                 1 #60 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Ser                 165   #               170   #               175 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Le #u Arg Thr Pro Asn Leu             180       #           185       #           190 Leu Ala Phe Val Arg Ala Val Lys His Leu Gl #u Asn Ala Ser Gly Ile         195           #       200           #       205 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala     210               #   215               #   220 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu 225                 2 #30                 2 #35                 2 #40 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln                 245   #               250   #               255 Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 134:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #134: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Glu                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 135:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #135: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Glu                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 136:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 244 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #136: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Asn Cys Ser Ile Met Il #e Asp Glu Ile Ile His     130               #   135               #   140 His Leu Lys Arg Pro Pro Ala Pro Leu Leu As #p Pro Asn Asn Leu Asn 145                 1 #50                 1 #55                 1 #60 Asp Glu Asp Val Ser Ile Leu Met Asp Arg As #n Leu Arg Leu Pro Asn                 165   #               170   #               175 Leu Glu Ser Phe Val Arg Ala Val Lys Asn Le #u Glu Asn Ala Ser Gly             180       #           185       #           190 Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cy #s Leu Pro Ser Ala Thr         195           #       200           #       205 Ala Ala Pro Ser Arg His Pro Ile Ile Ile Ly #s Ala Gly Asp Trp Gln     210               #   215               #   220 Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Va #l Thr Leu Glu Gln Ala 225                 2 #30                 2 #35                 2 #40 Gln Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 137:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 259 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #137: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His 145                 1 #50                 1 #55                 1 #60 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Asp                 165   #               170   #               175 Glu Asp Val Ser Ile Leu Met Asp Arg Asn Le #u Arg Leu Pro Asn Leu             180       #           185       #           190 Glu Ser Phe Val Arg Ala Val Lys Asn Leu Gl #u Asn Ala Ser Gly Ile         195           #       200           #       205 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala     210               #   215               #   220 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu 225                 2 #30                 2 #35                 2 #40 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln                 245   #               250   #               255 Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 138:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #138: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Se #r Ser Leu Pro Gln Ser 145                 1 #50                 1 #55                 1 #60 Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Ly #s Ile Gln Gly Asp Gly                 165   #               170   #               175 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Ty #r Lys Leu Cys His Pro             180       #           185       #           190 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gl #y Ile Pro Trp Ala Pro         195           #       200           #       205 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Le #u Ala Gly Cys Leu Ser     210               #   215               #   220 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gl #y Leu Leu Gln Ala Leu 225                 2 #30                 2 #35                 2 #40 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Le #u Asp Thr Leu Gln Leu                 245   #               250   #               255 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gl #n Gln Met Glu Glu Leu             260       #           265       #           270 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gl #y Ala Met Pro Ala Phe         275           #       280           #       285 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Va #l Leu Val Ala Ser His     290               #   295               #   300 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Va #l Leu Arg His Leu Ala 305                 3 #10                 3 #15                 3 #20 Gln Pro (2) INFORMATION FOR SEQ ID NO: 139:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 349 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #139: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #n Pro Pro Val Asn Ala         115           #       120           #       125 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gl #y Ser Glu Gly Gly Gly     130               #   135               #   140 Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Se #r Glu Gly Gly Gly Ser 145                 1 #50                 1 #55                 1 #60 Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Ty #r Glu Asn Met Ala Thr                 165   #               170   #               175 Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Se #r Phe Leu Leu Lys Ser             180       #           185       #           190 Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gl #y Ala Ala Leu Gln Glu         195           #       200           #       205 Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pr #o Glu Glu Leu Val Leu     210               #   215               #   220 Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pr #o Leu Ser Ser Cys Pro 225                 2 #30                 2 #35                 2 #40 Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Se #r Gln Leu His Ser Gly                 245   #               250   #               255 Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Le #u Glu Gly Ile Ser Pro             260       #           265       #           270 Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Le #u Asp Val Ala Asp Phe         275           #       280           #       285 Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Le #u Gly Met Ala Pro Ala     290               #   295               #   300 Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Ph #e Ala Ser Ala Phe Gln 305                 3 #10                 3 #15                 3 #20 Arg Arg Ala Gly Gly Val Leu Val Ala Ser Hi #s Leu Gln Ser Phe Leu                 325   #               330   #               335 Glu Val Ser Tyr Arg Val Leu Arg His Leu Al #a Gln Pro             340       #           345 (2) INFORMATION FOR SEQ ID NO: 140:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 64 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #140: GGATCCACCA TGAGCCGCCT GCCCGTCCTG CTCCTGCTCC AACTCCTGGT CC #GCCCCGCC     60 ATGG                  #                   #                   #             64 (2) INFORMATION FOR SEQ ID NO: 141:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 259 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #141: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Pro Ala Arg Ser Pro Se #r Pro Ser Thr Gln Pro     130               #   135               #   140 Trp Glu His Val Asn Ala Ile Gln Glu Ala Ar #g Arg Leu Leu Asn Leu 145                 1 #50                 1 #55                 1 #60 Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Th #r Val Glu Val Ile Ser                 165   #               170   #               175 Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Le #u Gln Thr Arg Leu Glu             180       #           185       #           190 Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Th #r Lys Leu Lys Gly Pro         195           #       200           #       205 Leu Thr Met Met Ala Ser His Tyr Lys Gln Hi #s Cys Pro Pro Thr Pro     210               #   215               #   220 Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Ph #e Glu Ser Phe Lys Glu 225                 2 #30                 2 #35                 2 #40 Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Ph #e Asp Cys Trp Glu Pro                 245   #               250   #               255 Val Gln Glu (2) INFORMATION FOR SEQ ID NO: 142:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 301 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #142: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #n Pro Pro Val Asn Ala         115           #       120           #       125 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gl #y Ser Glu Gly Gly Gly     130               #   135               #   140 Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Se #r Glu Gly Gly Gly Ser 145                 1 #50                 1 #55                 1 #60 Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Ty #r Glu Asn Met Ala Pro                 165   #               170   #               175 Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Tr #p Glu His Val Asn Ala             180       #           185       #           190 Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Se #r Arg Asp Thr Ala Ala         195           #       200           #       205 Glu Met Asn Glu Thr Val Glu Val Ile Ser Gl #u Met Phe Asp Leu Gly     210               #   215               #   220 Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Le #u Tyr Lys Gln Gly Leu 225                 2 #30                 2 #35                 2 #40 Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Le #u Thr Met Met Ala Ser                 245   #               250   #               255 His Tyr Lys Gln His Cys Pro Pro Thr Pro Gl #u Thr Ser Cys Ala Thr             260       #           265       #           270 Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu As #n Leu Lys Asp Phe Leu         275           #       280           #       285 Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Va #l Gln Glu     290               #   295               #   300 (2) INFORMATION FOR SEQ ID NO: 143:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 335 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #143: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Pro Val Asn Ala Gly Gly Gly Se #r Gly Gly Gly Ser Gly         115           #       120           #       125 Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gl #y Gly Ser Glu Gly Gly     130               #   135               #   140 Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly Se #r Gly Ser Gly Asn Met 145                 1 #50                 1 #55                 1 #60 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pr #o Gln Ser Phe Leu Leu                 165   #               170   #               175 Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gl #y Asp Gly Ala Ala Leu             180       #           185       #           190 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cy #s His Pro Glu Glu Leu         195           #       200           #       205 Val Leu Leu Gly His Ser Leu Gly Ile Pro Tr #p Ala Pro Leu Ser Ser     210               #   215               #   220 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cy #s Leu Ser Gln Leu His 225                 2 #30                 2 #35                 2 #40 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gl #n Ala Leu Glu Gly Ile                 245   #               250   #               255 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Le #u Gln Leu Asp Val Ala             260       #           265       #           270 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Gl #u Glu Leu Gly Met Ala         275           #       280           #       285 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pr #o Ala Phe Ala Ser Ala     290               #   295               #   300 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Al #a Ser His Leu Gln Ser 305                 3 #10                 3 #15                 3 #20 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg Hi #s Leu Ala Gln Pro                 325   #               330   #               335 (2) INFORMATION FOR SEQ ID NO: 144:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 274 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #144: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Pro Ala Arg Ser Pro Ser Pr #o Ser Thr Gln Pro Trp 145                 1 #50                 1 #55                 1 #60 Glu His Val Asn Ala Ile Gln Glu Ala Arg Ar #g Leu Leu Asn Leu Ser                 165   #               170   #               175 Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Va #l Glu Val Ile Ser Glu             180       #           185       #           190 Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gl #n Thr Arg Leu Glu Leu         195           #       200           #       205 Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Ly #s Leu Lys Gly Pro Leu     210               #   215               #   220 Thr Met Met Ala Ser His Tyr Lys Gln His Cy #s Pro Pro Thr Pro Glu 225                 2 #30                 2 #35                 2 #40 Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Gl #u Ser Phe Lys Glu Asn                 245   #               250   #               255 Leu Lys Asp Phe Leu Leu Val Ile Pro Phe As #p Cys Trp Glu Pro Val             260       #           265       #           270 Gln Glu (2) INFORMATION FOR SEQ ID NO: 145:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 317 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #145: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Pro Val Pro Pro Gly Gl #u Asp Ser Lys Asp Val     130               #   135               #   140 Ala Ala Pro His Arg Gln Pro Leu Thr Ser Se #r Glu Arg Ile Asp Lys 145                 1 #50                 1 #55                 1 #60 Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Al #a Leu Arg Lys Glu Thr                 165   #               170   #               175 Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Ly #s Glu Ala Leu Ala Glu             180       #           185       #           190 Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Ly #s Asp Gly Cys Phe Gln         195           #       200           #       205 Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Ly #s Ile Ile Thr Gly Leu     210               #   215               #   220 Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gl #n Asn Arg Phe Glu Ser 225                 2 #30                 2 #35                 2 #40 Ser Glu Glu Gln Ala Arg Ala Val Gln Met Se #r Thr Lys Val Leu Ile                 245   #               250   #               255 Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu As #p Ala Ile Thr Thr Pro             260       #           265       #           270 Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Ly #s Leu Gln Ala Gln Asn         275           #       280           #       285 Gln Trp Leu Gln Asp Met Thr Thr His Leu Il #e Leu Arg Ser Phe Lys     290               #   295               #   300 Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Ar #g Gln Met 305                 3 #10                 3 #15 (2) INFORMATION FOR SEQ ID NO: 146:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #146: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #y Gly Ser Gly Gly Gly             180       #           185       #           190 Ser Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His         195           #       200           #       205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Ser     210               #   215               #   220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Le #u Arg Thr Pro Asn Leu 225                 2 #30                 2 #35                 2 #40 Leu Ala Phe Val Arg Ala Val Lys His Leu Gl #u Asn Ala Ser Gly Ile                 245   #               250   #               255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala             260       #           265       #           270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu         275           #       280           #       285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln     290               #   295               #   300 Glu Gln Gln 305 (2) INFORMATION FOR SEQ ID NO: 147:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #147: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gly 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #y Gly Ser Gly Gly Gln             180       #           185       #           190 Ser Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His         195           #       200           #       205 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Asp     210               #   215               #   220 Glu Asp Val Ser Ile Leu Met Asp Arg Asn Le #u Arg Leu Pro Asn Leu 225                 2 #30                 2 #35                 2 #40 Glu Ser Phe Val Arg Ala Val Lys Asn Leu Gl #u Asn Ala Ser Gly Ile                 245   #               250   #               255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala             260       #           265       #           270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu         275           #       280           #       285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln     290               #   295               #   300 Glu Gln Gln 305 (2) INFORMATION FOR SEQ ID NO: 148:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 337 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #148: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Pro Gln Pro Pro Val Asn Ala Gly Gl #y Gly Ser Gly Gly Gly             180       #           185       #           190 Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Gl #u Gly Gly Gly Ser Glu         195           #       200           #       205 Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gl #y Gly Ser Gly Ser Gly     210               #   215               #   220 Asp Phe Asp Tyr Glu Asn Met Ala Asn Cys Se #r Ile Met Ile Asp Glu 225                 2 #30                 2 #35                 2 #40 Ile Ile His His Leu Lys Arg Pro Pro Ala Pr #o Leu Leu Asp Pro Asn                 245   #               250   #               255 Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Me #t Asp Arg Asn Leu Arg             260       #           265       #           270 Leu Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala         275           #       280           #       285 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro     290               #   295               #   300 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg 305                 3 #10                 3 #15                 3 #20 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln                 325   #               330   #               335 Gln (2) INFORMATION FOR SEQ ID NO: 149:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #149: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #u Pro Ser Gly Pro Ile             180       #           185       #           190 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pro         195           #       200           #       205 Asn Met Ala Asn Cys Ser Ile Met Ile Asp Gl #u Ile Ile His His Leu     210               #   215               #   220 Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro As #n Asn Leu Asn Asp Glu 225                 2 #30                 2 #35                 2 #40 Asp Val Ser Ile Leu Met Asp Arg Asn Leu Ar #g Leu Pro Asn Leu Glu                 245   #               250   #               255 Ser Phe Val Arg Ala Val Lys Asn Leu Glu As #n Ala Ser Gly Ile Glu             260       #           265       #           270 Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pr #o Ser Ala Thr Ala Ala         275           #       280           #       285 Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gl #y Asp Trp Gln Glu Phe     290               #   295               #   300 Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Le #u Glu Gln Ala Gln Glu 305                 3 #10                 3 #15                 3 #20 Gln Gln (2) INFORMATION FOR SEQ ID NO: 150:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #150: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Le 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Al             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Gl         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Se     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Le 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gl                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Va             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Me         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Se     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gl 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pr                 165   #               170   #               175 Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #u Pro Ser Gly Pro Il             180       #           185       #           190 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pr         195           #       200           #       205 Asn Met Ala Asn Cys Ser Ile Met Ile Asp Gl #u Ile Ile His His Le     210               #   215               #   220 Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro As #n Asn Leu Asn Ser Gl 225                 2 #30                 2 #35                 2 #40 Asp Met Asp Ile Leu Met Glu Arg Asn Leu Ar #g Thr Pro Asn Leu Le                 245   #               250   #               255 Ala Phe Val Arg Ala Val Lys His Leu Glu As #n Ala Ser Gly Ile Gl             260       #           265       #           270 Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pr #o Ser Ala Thr Ala Al         275           #       280           #       285 Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gl #y Asp Trp Gln Glu Ph     290               #   295               #   300 Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Le #u Glu Gln Ala Gln Gl 305                 3 #10                 3 #15                 3 #20 Gln Gln (2) INFORMATION FOR SEQ ID NO: 151:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 349 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #151: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Ile Glu Gly Arg Ile Ser Pro Gln Pr #o Pro Val Asn Ala Gly             180       #           185       #           190 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Se #r Glu Gly Gly Gly Ser         195           #       200           #       205 Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gl #u Gly Gly Gly Ser Gly     210               #   215               #   220 Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr Gl #u Asn Met Ala Asn Cys 225                 2 #30                 2 #35                 2 #40 Ser Ile Met Ile Asp Glu Ile Ile His His Le #u Lys Arg Pro Pro Asn                 245   #               250   #               255 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Gl #u Asp Met Asp Ile Leu             260       #           265       #           270 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Le #u Ala Phe Val Arg Ala         275           #       280           #       285 Val Lys His Leu Glu Asn Ala Ser Gly Ile Gl #u Ala Ile Leu Arg Asn     290               #   295               #   300 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Al #a Pro Ser Arg His Pro 305                 3 #10                 3 #15                 3 #20 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Ph #e Arg Glu Lys Leu Thr                 325   #               330   #               335 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Gl #u Gln Gln             340       #           345 (2) INFORMATION FOR SEQ ID NO: 152:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #152: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Al #a Ser Ser Leu Pro Gln     130               #   135               #   140 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Ar #g Lys Ile Gln Gly Asp 145                 1 #50                 1 #55                 1 #60 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Th #r Tyr Lys Leu Cys His                 165   #               170   #               175 Pro Glu Glu Leu Val Leu Leu Gly His Ser Le #u Gly Ile Pro Trp Ala             180       #           185       #           190 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gl #n Leu Ala Gly Cys Leu         195           #       200           #       205 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gl #n Gly Leu Leu Gln Ala     210               #   215               #   220 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Th #r Leu Asp Thr Leu Gln 225                 2 #30                 2 #35                 2 #40 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Tr #p Gln Gln Met Glu Glu                 245   #               250   #               255 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gl #n Gly Ala Met Pro Ala             260       #           265       #           270 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gl #y Val Leu Val Ala Ser         275           #       280           #       285 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Ar #g Val Leu Arg His Leu     290               #   295               #   300 Ala Gln Pro 305 (2) INFORMATION FOR SEQ ID NO: 153:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 244 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #153: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Asn Cys Ser Ile Met Il #e Asp Glu Ile Ile His     130               #   135               #   140 His Leu Lys Arg Pro Pro Ala Pro Leu Leu As #p Pro Asn Asn Leu Asn 145                 1 #50                 1 #55                 1 #60 Asp Glu Asp Val Ser Ile Leu Met Asp Arg As #n Leu Arg Leu Pro Asn                 165   #               170   #               175 Leu Glu Ser Phe Val Arg Ala Val Lys Asn Le #u Glu Asn Ala Ser Gly             180       #           185       #           190 Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cy #s Leu Pro Ser Ala Thr         195           #       200           #       205 Ala Ala Pro Ser Arg His Pro Ile Ile Ile Ly #s Ala Gly Asp Trp Gln     210               #   215               #   220 Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Va #l Thr Leu Glu Gln Ala 225                 2 #30                 2 #35                 2 #40 Gln Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 154:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #154: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Gly Gly Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Se #r Ser Leu Pro Gln Ser 145                 1 #50                 1 #55                 1 #60 Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Ly #s Ile Gln Gly Asp Gly                 165   #               170   #               175 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Ty #r Lys Leu Cys His Pro             180       #           185       #           190 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gl #y Ile Pro Trp Ala Pro         195           #       200           #       205 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Le #u Ala Gly Cys Leu Ser     210               #   215               #   220 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gl #y Leu Leu Gln Ala Leu 225                 2 #30                 2 #35                 2 #40 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Le #u Asp Thr Leu Gln Leu                 245   #               250   #               255 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gl #n Gln Met Glu Glu Leu             260       #           265       #           270 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gl #y Ala Met Pro Ala Phe         275           #       280           #       285 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Va #l Leu Val Ala Ser His     290               #   295               #   300 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Va #l Leu Arg His Leu Ala 305                 3 #10                 3 #15                 3 #20 Gln Pro (2) INFORMATION FOR SEQ ID NO: 155:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 259 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #155: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn As #n Leu Asn Asp Glu Asp             20       #            25       #            30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Le #u Pro Asn Leu Glu Ser         35           #        40           #        45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Glu Pro Ser Gly Pro         115           #       120           #       125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Ly #s Glu Ser His Lys Ser     130               #   135               #   140 Pro Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His 145                 1 #50                 1 #55                 1 #60 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Asp                 165   #               170   #               175 Glu Asp Val Ser Ile Leu Met Asp Arg Asn Le #u Arg Leu Pro Asn Leu             180       #           185       #           190 Glu Ser Phe Val Arg Ala Val Lys Asn Leu Gl #u Asn Ala Ser Gly Ile         195           #       200           #       205 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala     210               #   215               #   220 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu 225                 2 #30                 2 #35                 2 #40 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln                 245   #               250   #               255 Glu Gln Gln (2) INFORMATION FOR SEQ ID NO: 156:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #156: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gly Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gl #u Pro Ser Gly Pro Ile             180       #           185       #           190 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pro         195           #       200           #       205 Asn Met Ala Asn Cys Ser Ile Met Ile Asp Gl #u Ile Ile His His Leu     210               #   215               #   220 Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro As #n Asn Leu Asn Asp Glu 225                 2 #30                 2 #35                 2 #40 Asp Val Ser Ile Leu Met Asp Arg Asn Leu Ar #g Leu Pro Asn Leu Glu                 245   #               250   #               255 Ser Phe Val Arg Ala Val Lys Asn Leu Glu As #n Ala Ser Gly Ile Glu             260       #           265       #           270 Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pr #o Ser Ala Thr Ala Ala         275           #       280           #       285 Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gl #y Asp Trp Gln Glu Phe     290               #   295               #   300 Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Le #u Glu Gln Ala Gln Glu 305                 3 #10                 3 #15                 3 #20 Gln Gln (2) INFORMATION FOR SEQ ID NO: 157:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 322 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #157: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gly Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gl #u Pro Ser Gly Pro Ile             180       #           185       #           190 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pro         195           #       200           #       205 Asn Met Ala Asn Cys Ser Ile Met Ile Asp Gl #u Ile Ile His His Leu     210               #   215               #   220 Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro As #n Asn Leu Asn Asp Glu 225                 2 #30                 2 #35                 2 #40 Asp Val Ser Ile Leu Met Asp Arg Asn Leu Ar #g Leu Pro Asn Leu Glu                 245   #               250   #               255 Ser Phe Val Arg Ala Val Lys Asn Leu Glu As #n Ala Ser Gly Ile Glu             260       #           265       #           270 Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pr #o Ser Ala Thr Ala Ala         275           #       280           #       285 Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gl #y Asp Trp Gln Glu Phe     290               #   295               #   300 Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Le #u Glu Gln Ala Gln Glu 305                 3 #10                 3 #15                 3 #20 Gln Gln (2) INFORMATION FOR SEQ ID NO: 158:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #158: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gly Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gl #y Gly Ser Gly Gly Gly             180       #           185       #           190 Ser Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His         195           #       200           #       205 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Asp     210               #   215               #   220 Glu Asp Val Ser Ile Leu Met Asp Arg Asn Le #u Arg Leu Pro Asn Leu 225                 2 #30                 2 #35                 2 #40 Glu Ser Phe Val Arg Ala Val Lys Asn Leu Gl #u Asn Ala Ser Gly Ile                 245   #               250   #               255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala             260       #           265       #           270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu         275           #       280           #       285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln     290               #   295               #   300 Glu Gln Gln 305 (2) INFORMATION FOR SEQ ID NO: 159:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 307 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #159: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gly Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gly 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gl #y Gly Ser Gly Gly Gly             180       #           185       #           190 Ser Asn Met Ala Asn Cys Ser Ile Met Ile As #p Glu Ile Ile His His         195           #       200           #       205 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pr #o Asn Asn Leu Asn Asp     210               #   215               #   220 Glu Asp Val Ser Ile Leu Met Asp Arg Asn Le #u Arg Leu Pro Asn Leu 225                 2 #30                 2 #35                 2 #40 Glu Ser Phe Val Arg Ala Val Lys Asn Leu Gl #u Asn Ala Ser Gly Ile                 245   #               250   #               255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Le #u Pro Ser Ala Thr Ala             260       #           265       #           270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Al #a Gly Asp Trp Gln Glu         275           #       280           #       285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Th #r Leu Glu Gln Ala Gln     290               #   295               #   300 Glu Gln Gln 305 (2) INFORMATION FOR SEQ ID NO: 160:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 128 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #160: Met Ala Pro Ala Arg Ser Pro Ser Pro Ser Th #r Gln Pro Trp Glu His 1               5    #                10   #                15 Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Le #u Asn Leu Ser Arg Asp             20       #            25       #            30 Thr Ala Ala Glu Met Asn Glu Thr Val Glu Va #l Ile Ser Glu Met Phe         35           #        40           #        45 Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Ar #g Leu Glu Leu Tyr Lys     50               #    55               #    60 Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Ly #s Gly Pro Leu Thr Met 65                   #70                   #75                   #80 Met Ala Ser His Tyr Lys Gln His Cys Pro Pr #o Thr Pro Glu Thr Ser                 85   #                90   #                95 Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Ph #e Lys Glu Asn Leu Lys             100       #           105       #           110 Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Tr #p Glu Pro Val Gln Glu         115           #       120           #       125 (2) INFORMATION FOR SEQ ID NO: 161:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 176 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #161: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 (2) INFORMATION FOR SEQ ID NO: 162:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 176 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #162: Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Le #u Pro Gln Ser Phe Leu 1               5    #                10   #                15 Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gl #n Gly Asp Gly Ala Ala             20       #            25       #            30 Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Le #u Cys His Pro Glu Glu         35           #        40           #        45 Leu Val Leu Leu Gly His Ser Leu Gly Ile Pr #o Trp Ala Pro Leu Ser     50               #    55               #    60 Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gl #y Cys Leu Ser Gln Leu 65                   #70                   #75                   #80 His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Le #u Gln Ala Leu Glu Gly                 85   #                90   #                95 Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Th #r Leu Gln Leu Asp Val             100       #           105       #           110 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Me #t Glu Glu Leu Gly Met         115           #       120           #       125 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Me #t Pro Ala Phe Ala Ser     130               #   135               #   140 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Va #l Ala Ser His Leu Gln 145                 1 #50                 1 #55                 1 #60 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Ar #g His Leu Ala Gln Pro                 165   #               170   #               175 (2) INFORMATION FOR SEQ ID NO: 163:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 186 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #163: Met Ala Pro Val Pro Pro Gly Glu Asp Ser Ly #s Asp Val Ala Ala Pro 1               5    #                10   #                15 His Arg Gln Pro Leu Thr Ser Ser Glu Arg Il #e Asp Lys Gln Ile Arg             20       #            25       #            30 Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Ly #s Glu Thr Cys Asn Lys         35           #        40           #        45 Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Le #u Ala Glu Asn Asn Leu     50               #    55               #    60 Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cy #s Phe Gln Ser Gly Phe 65                   #70                   #75                   #80 Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Th #r Gly Leu Leu Glu Phe                 85   #                90   #                95 Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Ph #e Glu Ser Ser Glu Glu             100       #           105       #           110 Gln Ala Arg Ala Val Gln Met Ser Thr Lys Va #l Leu Ile Gln Phe Leu         115           #       120           #       125 Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Th #r Thr Pro Asp Pro Thr     130               #   135               #   140 Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Al #a Gln Asn Gln Trp Leu 145                 1 #50                 1 #55                 1 #60 Gln Asp Met Thr Thr His Leu Ile Leu Arg Se #r Phe Lys Glu Phe Leu                 165   #               170   #               175 Gln Ser Ser Leu Arg Ala Leu Arg Gln Met             180       #           185 (2) INFORMATION FOR SEQ ID NO: 164:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 155 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #164: Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Le #u Arg Val Leu Ser Lys 1               5    #                10   #                15 Leu Leu Arg Asp Ser His Val Leu His Ser Ar #g Leu Ser Gln Cys Pro             20       #            25       #            30 Glu Val His Pro Leu Pro Thr Pro Val Leu Le #u Pro Ala Val Asp Phe         35           #        40           #        45 Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Gl #u Thr Lys Ala Gln Asp     50               #    55               #    60 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gl #y Val Met Ala Ala Arg 65                   #70                   #75                   #80 Gln Gln Leu Gly Pro Thr Cys Leu Ser Ser Le #u Leu Gly Gln Leu Ser                 85   #                90   #                95 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gl #n Ser Leu Leu Gly Thr             100       #           105       #           110 Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala Hi #s Lys Asp Pro Asn Ala         115           #       120           #       125 Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gl #y Lys Val Arg Phe Leu     130               #   135               #   140 Met Leu Val Gly Gly Ser Thr Leu Cys Val Ar #g 145                 1 #50                 1 #55 (2) INFORMATION FOR SEQ ID NO: 165:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 286 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #165: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Ile Glu Gly Arg Ile Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Ser Pro Ala Pro Pro Al #a Cys Asp Leu Arg Val     130               #   135               #   140 Leu Ser Lys Leu Leu Arg Asp Ser His Val Le #u His Ser Arg Leu Ser 145                 1 #50                 1 #55                 1 #60 Gln Cys Pro Glu Val His Pro Leu Pro Thr Pr #o Val Leu Leu Pro Ala                 165   #               170   #               175 Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gl #n Met Glu Glu Thr Lys             180       #           185       #           190 Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Le #u Leu Glu Gly Val Met         195           #       200           #       205 Ala Ala Arg Gln Gln Leu Gly Pro Thr Cys Le #u Ser Ser Leu Leu Gly     210               #   215               #   220 Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gl #y Ala Leu Gln Ser Leu 225                 2 #30                 2 #35                 2 #40 Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Th #r Thr Ala His Lys Asp                 245   #               250   #               255 Pro Asn Ala Ile Phe Leu Ser Phe Gln His Le #u Leu Arg Gly Lys Val             260       #           265       #           270 Arg Phe Leu Met Leu Val Gly Gly Ser Thr Le #u Cys Val Arg         275           #       280           #       285 (2) INFORMATION FOR SEQ ID NO: 166:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 286 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #166: Met Ala Asn Cys Ser Ile Met Ile Asp Glu Il #e Ile His His Leu Lys 1               5    #                10   #                15 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn As #n Leu Asn Ser Glu Asp             20       #            25       #            30 Met Asp Ile Leu Met Glu Arg Asn Leu Arg Th #r Pro Asn Leu Leu Ala         35           #        40           #        45 Phe Val Arg Ala Val Lys His Leu Glu Asn Al #a Ser Gly Ile Glu Ala     50               #    55               #    60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Se #r Ala Thr Ala Ala Pro 65                   #70                   #75                   #80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly As #p Trp Gln Glu Phe Arg                 85   #                90   #                95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gl #u Gln Ala Gln Glu Gln             100       #           105       #           110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gl #y Gly Gly Ser Gly Gly         115           #       120           #       125 Gly Ser Asn Met Ala Ser Pro Ala Pro Pro Al #a Cys Asp Leu Arg Val     130               #   135               #   140 Leu Ser Lys Leu Leu Arg Asp Ser His Val Le #u His Ser Arg Leu Ser 145                 1 #50                 1 #55                 1 #60 Gln Cys Pro Glu Val His Pro Leu Pro Thr Pr #o Val Leu Leu Pro Ala                 165   #               170   #               175 Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gl #n Met Glu Glu Thr Lys             180       #           185       #           190 Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Le #u Leu Glu Gly Val Met         195           #       200           #       205 Ala Ala Arg Gln Gln Leu Gly Pro Thr Cys Le #u Ser Ser Leu Leu Gly     210               #   215               #   220 Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gl #y Ala Leu Gln Ser Leu 225                 2 #30                 2 #35                 2 #40 Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Th #r Thr Ala His Lys Asp                 245   #               250   #               255 Pro Asn Ala Ile Phe Leu Ser Phe Gln His Le #u Leu Arg Gly Lys Val             260       #           265       #           270 Arg Phe Leu Met Leu Val Gly Gly Ser Thr Le #u Cys Val Arg         275           #       280           #       285 (2) INFORMATION FOR SEQ ID NO: 167:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 286 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #167: Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Le #u Arg Val Leu Ser Lys 1               5    #                10   #                15 Leu Leu Arg Asp Ser His Val Leu His Ser Ar #g Leu Ser Gln Cys Pro             20       #            25       #            30 Glu Val His Pro Leu Pro Thr Pro Val Leu Le #u Pro Ala Val Asp Phe         35           #        40           #        45 Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Gl #u Thr Lys Ala Gln Asp     50               #    55               #    60 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gl #y Val Met Ala Ala Arg 65                   #70                   #75                   #80 Gln Gln Leu Gly Pro Thr Cys Leu Ser Ser Le #u Leu Gly Gln Leu Ser                 85   #                90   #                95 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gl #n Ser Leu Leu Gly Thr             100       #           105       #           110 Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala Hi #s Lys Asp Pro Asn Ala         115           #       120           #       125 Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gl #y Lys Val Arg Phe Leu     130               #   135               #   140 Met Leu Val Gly Gly Ser Thr Leu Cys Val Ar #g Tyr Val Ile Glu Gly 145                 1 #50                 1 #55                 1 #60 Arg Ile Ser Pro Gly Gly Gly Ser Gly Gly Gl #y Ser Asn Met Ala Asn                 165   #               170   #               175 Cys Ser Ile Met Ile Asp Glu Ile Ile His Hi #s Leu Lys Arg Pro Pro             180       #           185       #           190 Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Se #r Glu Asp Met Asp Ile         195           #       200           #       205 Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Le #u Leu Ala Phe Val Arg     210               #   215               #   220 Ala Val Lys His Leu Glu Asn Ala Ser Gly Il #e Glu Ala Ile Leu Arg 225                 2 #30                 2 #35                 2 #40 Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Al #a Ala Pro Ser Arg His                 245   #               250   #               255 Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Gl #u Phe Arg Glu Lys Leu             260       #           265       #           270 Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gl #n Glu Gln Gln         275           #       280           #       285 (2) INFORMATION FOR SEQ ID NO: 168:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 290 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: protein     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #168: Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Le #u Arg Val Leu Ser Lys 1               5    #                10   #                15 Leu Leu Arg Asp Ser His Val Leu His Ser Ar #g Leu Ser Gln Cys Pro             20       #            25       #            30 Glu Val His Pro Leu Pro Thr Pro Val Leu Le #u Pro Ala Val Asp Phe         35           #        40           #        45 Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Gl #u Thr Lys Ala Gln Asp     50               #    55               #    60 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gl #y Val Met Ala Ala Arg 65                   #70                   #75                   #80 Gln Gln Leu Gly Pro Thr Cys Leu Ser Ser Le #u Leu Gly Gln Leu Ser                 85   #                90   #                95 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gl #n Ser Leu Leu Gly Thr             100       #           105       #           110 Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala Hi #s Lys Asp Pro Asn Ala         115           #       120           #       125 Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gl #y Lys Val Arg Phe Leu     130               #   135               #   140 Met Leu Val Gly Gly Ser Thr Leu Cys Val Ar #g Glu Phe His Ala Tyr 145                 1 #50                 1 #55                 1 #60 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gl #y Ser Gly Gly Gly Ser                 165   #               170   #               175 Asn Met Ala Asn Cys Ser Ile Met Ile Asp Gl #u Ile Ile His His Leu             180       #           185       #           190 Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro As #n Asn Leu Asn Ser Glu         195           #       200           #       205 Asp Met Asp Ile Leu Met Glu Arg Asn Leu Ar #g Thr Pro Asn Leu Leu     210               #   215               #   220 Ala Phe Val Arg Ala Val Lys His Leu Glu As #n Ala Ser Gly Ile Glu 225                 2 #30                 2 #35                 2 #40 Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pr #o Ser Ala Thr Ala Ala                 245   #               250   #               255 Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gl #y Asp Trp Gln Glu Phe             260       #           265       #           270 Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Le #u Glu Gln Ala Gln Glu         275           #       280           #       285 Gln Gln     290 (2) INFORMATION FOR SEQ ID NO: 169:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 45 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #169: ACGTCCATGG CNTCNCCNGC NCCNCCTGCT TGTGACCTCC GAGTC    #                   #45 (2) INFORMATION FOR SEQ ID NO: 170:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 34 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #170: AATAGCTGAA TTCTTACCCT TCCTGAGACA GATT        #                   #        34 (2) INFORMATION FOR SEQ ID NO: 171:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 33 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #171: TGACAAGCTT ACCTGACGCA GAGGGTGGAC CCT        #                   #         33 (2) INFORMATION FOR SEQ ID NO: 172:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 30 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #172: ATGCACGAAT TCCCTGACGC AGAGGGTGGA          #                   #           30 (2) INFORMATION FOR SEQ ID NO: 173:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 14 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #173: AATTCCATGC ATAC               #                   #                   #     14 (2) INFORMATION FOR SEQ ID NO: 174:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 10 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: single           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: other nucleic acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #174: GGTACGTATG                 #                   #                   #        10 (2) INFORMATION FOR SEQ ID NO: 175:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 561 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #175: ATGGCTCCAG TACCACCAGG TGAAGATTCC AAAGATGTGG CCGCCCCACA CA #GACAGCCA     60 CTCACCTCTT CAGAACGAAT TGACAAACAA ATTCGGTACA TCCTCGACGG GA #TATCAGCC    120 CTGAGAAAGG AGACATGTAA CAAGAGTAAC ATGTGTGAAA GCAGCAAAGA GG #CGCTAGCA    180 GAAAACAACC TGAACCTTCC AAAGATGGCT GAAAAAGATG GATGCTTCCA AT #CCGGATTC    240 AATGAGGAGA CTTGCCTGGT GAAAATCATC ACTGGTCTTT TGGAGTTTGA GG #TATACCTC    300 GAGTACCTCC AGAACAGATT TGAGAGTAGT GAGGAACAAG CCAGAGCTGT GC #AGATGTCG    360 ACAAAAGTCC TGATCCAGTT CCTGCAGAAA AAGGCAAAGA ATCTAGATGC AA #TAACCACC    420 CCTGACCCAA CCACAAATGC ATCCCTGCTG ACGAAGCTGC AGGCACAGAA CC #AGTGGCTG    480 CAGGACATGA CAACTCATCT CATTCTGCGC AGCTTTAAGG AGTTCCTGCA GT #CCAGCCTG    540 AGGGCTCTTC GGCAAATGTA G            #                   #                 561 (2) INFORMATION FOR SEQ ID NO: 176:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 402 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #176: ATGGCACCGG CTCGTTCCCC GTCCCCGTCT ACCCAGCCGT GGGAACACGT GA #ATGCCATC     60 CAGGAGGCCC GGCGTCTCCT GAACCTGAGT AGAGACACTG CTGCTGAGAT GA #ATGAAACA    120 GTAGAAGTGA TATCAGAAAT GTTTGACCTC CAGGAGCCGA CTTGCCTACA GA #CCCGCCTG    180 GAGCTGTACA AGCAGGGCCT GCGGGGCAGC CTCACCAAGC TCAAGGGCCC CT #TGACCATG    240 ATGGCCAGCC ACTACAAGCA GCACTGCCCT CCAACCCCGG AAACTTCCTG TG #CAACCCAG    300 ATTATCACCT TTGAAAGTTT CAAAGAGAAC CTGAAGGACT TCCTGCTTGT CA #TCCCCTTT    360 GACTGCTGGG AGCCAGTCCA GGAGTGATAA GGATCCGAAT TC     #                   # 402 (2) INFORMATION FOR SEQ ID NO: 177:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 546 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #177: ATGGCTACAC CATTAGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTG AT #AAGGATCC    540 GAATTC                  #                   #                   #          546 (2) INFORMATION FOR SEQ ID NO: 178:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 546 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #178: ATGGCTACAC CATTAGGACC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTGCTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTG AT #AAGGATCC    540 GAATTC                  #                   #                   #          546 (2) INFORMATION FOR SEQ ID NO: 179:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 546 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #179: ATGGCTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CA #AGTCTTTA     60 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GT #GTGCCACC    120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CA #TCCCCTGG    180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GA #GCCAACTC    240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT AT #CCCCCGAG    300 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CA #CCATCTGG    360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TG #CCATGCCG    420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CC #ATCTGCAG    480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTG AT #AAGGATCC    540 GAATTC                  #                   #                   #          546 (2) INFORMATION FOR SEQ ID NO: 180:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 465 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #180: ATGGCGTCTC CGGCGCCGCC TGCTTGTGAC CTCCGAGTCC TCAGTAAACT GC #TTCGTGAC     60 TCCCATGTCC TTCACAGCAG ACTGAGCCAG TGCCCAGAGG TTCACCCTTT GC #CTACACCT    120 GTCCTGCTGC CTGCTGTGGA CTTTAGCTTG GGAGAATGGA AAACCCAGAT GG #AGGAGACC    180 AAGGCACAGG ACATTCTGGG AGCAGTGACC CTTCTGCTGG AGGGAGTGAT GG #CAGCACGG    240 GGACAACTGG GACCCACTTG CCTCTCATCC CTCCTGGGGC AGCTTTCTGG AC #AGGTCCGT    300 CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT GGAACCCAGC TTCCTCCACA GG #GCAGGACC    360 ACAGCTCACA AGGATCCCAA TGCCATCTTC CTGAGCTTCC AACACCTGCT CC #GAGGAAAG    420 GTGCGTTTCC TGATGCTTGT AGGAGGGTCC ACCCTCTGCG TCAGG    #                 465 (2) INFORMATION FOR SEQ ID NO: 181:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 143 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #181: CCTGTCAACC CGGGCGGCGG CTCTGGTGGT GGTTCTGGTG GCGGCTCTGA GG #GTGGCGGC     60 TCTGAGGGTG GCGGTTCTGA GGGTGGCGGC TCTGAGGGTG GCGGTTCCGG TG #GCGGCTCC    120 GGTTCCGGTA ACATGTATTA TGA            #                   #               143 (2) INFORMATION FOR SEQ ID NO: 182:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 180 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #182: ATCGTCTGAC CTCCCGGGCC TCCTGTCAAT GCTGGCGGCG GCTCTGGTGG TG #GTTCTGGT     60 GGCGGCTCTG AGGGTGGCGG CTCTGAGGGT GGCGGTTCTG AGGGTGGCGG CT #CTGAGGGT    120 GGCGGTTCCG GTGGCGGCTC CGGTTCCGGT GATTTTGATT ATGAAAACAT GT #CAAACGCT    180 (2) INFORMATION FOR SEQ ID NO: 183:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 858 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #183: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAATCGA GG #GAAGGATT    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCGT CTCCGGCGCC GC #CTGCTTGT    420 GACCTCCGAG TCCTCAGTAA ACTGCTTCGT GACTCCCATG TCCTTCACAG CA #GACTGAGC    480 CAGTGCCCAG AGGTTCACCC TTTGCCTACA CCTGTCCTGC TGCCTGCTGT GG #ACTTTAGC    540 TTGGGAGAAT GGAAAACCCA GATGGAGGAG ACCAAGGCAC AGGACATTCT GG #GAGCAGTG    600 ACCCTTCTGC TGGAGGGAGT GATGGCAGCA CGGGGACAAC TGGGACCCAC TT #GCCTCTCA    660 TCCCTCCTGG GGCAGCTTTC TGGACAGGTC CGTCTCCTCC TTGGGGCCCT GC #AGAGCCTC    720 CTTGGAACCC AGCTTCCTCC ACAGGGCAGG ACCACAGCTC ACAAGGATCC CA #ATGCCATC    780 TTCCTGAGCT TCCAACACCT GCTCCGAGGA AAGGTGCGTT TCCTGATGCT TG #TAGGAGGG    840 TCCACCCTCT GCGTCAGG              #                   #                   # 858 (2) INFORMATION FOR SEQ ID NO: 184:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 858 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #184: ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG AC #CACCTAAC     60 CCTTTGCTGG ACCCGAACAA CCTCAATTCT GAAGACATGG ATATCCTGAT GG #AACGAAAC    120 CTTCGAACTC CAAACCTGCT CGCATTCGTA AGGGCTGTCA AGCACTTAGA AA #ATGCATCA    180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GG #CCGCACCC    240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AA #AACTGACG    300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CG #GTGGAGGC    360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCGT CTCCGGCGCC GC #CTGCTTGT    420 GACCTCCGAG TCCTCAGTAA ACTGCTTCGT GACTCCCATG TCCTTCACAG CA #GACTGAGC    480 CAGTGCCCAG AGGTTCACCC TTTGCCTACA CCTGTCCTGC TGCCTGCTGT GG #ACTTTAGC    540 TTGGGAGAAT GGAAAACCCA GATGGAGGAG ACCAAGGCAC AGGACATTCT GG #GAGCAGTG    600 ACCCTTCTGC TGGAGGGAGT GATGGCAGCA CGGGGACAAC TGGGACCCAC TT #GCCTCTCA    660 TCCCTCCTGG GGCAGCTTTC TGGACAGGTC CGTCTCCTCC TTGGGGCCCT GC #AGAGCCTC    720 CTTGGAACCC AGCTTCCTCC ACAGGGCAGG ACCACAGCTC ACAAGGATCC CA #ATGCCATC    780 TTCCTGAGCT TCCAACACCT GCTCCGAGGA AAGGTGCGTT TCCTGATGCT TG #TAGGAGGG    840 TCCACCCTCT GCGTCAGG              #                   #                   # 858 (2) INFORMATION FOR SEQ ID NO: 185:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 852 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #185: ATGGCGTCTC CGGCGCCGCC TGCTTGTGAC CTCCGAGTCC TCAGTAAACT GC #TTCGTGAC     60 TCCCATGTCC TTCACAGCAG ACTGAGCCAG TGCCCAGAGG TTCACCCTTT GC #CTACACCT    120 GTCCTGCTGC CTGCTGTGGA CTTTAGCTTG GGAGAATGGA AAACCCAGAT GG #AGGAGACC    180 AAGGCACAGG ACATTCTGGG AGCAGTGACC CTTCTGCTGG AGGGAGTGAT GG #CAGCACGG    240 GGACAACTGG GACCCACTTG CCTCTCATCC CTCCTGGGGC AGCTTTCTGG AC #AGGTCCGT    300 CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT GGAACCCAGC TTCCTCCACA GG #GCAGGACC    360 ACAGCTCACA AGGATCCCAA TGCCATCTTC CTGAGCTTCC AACACCTGCT CC #GAGGAAAG    420 GTGCGTTTCC TGATGCTTGT AGGAGGGTCC ACCCTCTGCG TCAGGATCGA GG #GAAGGATT    480 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA ACTGCTCTAT AA #TGATCGAT    540 GAAATTATAC ATCACTTAAA GAGACCACCT AACCCTTTGC TGGACCCGAA CA #ACCTCAAT    600 TCTGAAGACA TGGATATCCT GATGGAACGA AACCTTCGAA CTCCAAACCT GC #TCGCATTC    660 GTAAGGGCTG TCAAGCACTT AGAAAATGCA TCAGGTATTG AGGCAATTCT TC #GTAATCTC    720 CAACCATGTC TGCCCTCTGC CACGGCCGCA CCCTCTCGAC ATCCAATCAT CA #TCAAGGCA    780 GGTGACTGGC AAGAATTCCG GGAAAAACTG ACGTTCTATC TGGTTACCCT TG #AGCAAGCG    840 CAGGAACAAC AG               #                   #                   #      852 (2) INFORMATION FOR SEQ ID NO: 186:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 870 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA (genomic)     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #186: ATGGCGTCTC CGGCGCCGCC TGCTTGTGAC CTCCGAGTCC TCAGTAAACT GC #TTCGTGAC     60 TCCCATGTCC TTCACAGCAG ACTGAGCCAG TGCCCAGAGG TTCACCCTTT GC #CTACACCT    120 GTCCTGCTGC CTGCTGTGGA CTTTAGCTTG GGAGAATGGA AAACCCAGAT GG #AGGAGACC    180 AAGGCACAGG ACATTCTGGG AGCAGTGACC CTTCTGCTGG AGGGAGTGAT GG #CAGCACGG    240 GGACAACTGG GACCCACTTG CCTCTCATCC CTCCTGGGGC AGCTTTCTGG AC #AGGTCCGT    300 CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT GGAACCCAGC TTCCTCCACA GG #GCAGGACC    360 ACAGCTCACA AGGATCCCAA TGCCATCTTC CTGAGCTTCC AACACCTGCT CC #GAGGAAAG    420 GTGCGTTTCC TGATGCTTGT AGGAGGGTCC ACCCTCTGCG TCAGGGAATT CC #ATGCATAC    480 GTAGAGGGCG GTGGAGGCTC CCCGGGTGGT GGTTCTGGCG GCGGCTCCAA CA #TGGCTAAC    540 TGCTCTATAA TGATCGATGA AATTATACAT CACTTAAAGA GACCACCTAA CC #CTTTGCTG    600 GACCCGAACA ACCTCAATTC TGAAGACATG GATATCCTGA TGGAACGAAA CC #TTCGAACT    660 CCAAACCTGC TCGCATTCGT AAGGGCTGTC AAGCACTTAG AAAATGCATC AG #GTATTGAG    720 GCAATTCTTC GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC CT #CTCGACAT    780 CCAATCATCA TCAAGGCAGG TGACTGGCAA GAATTCCGGG AAAAACTGAC GT #TCTATCTG    840 GTTACCCTTG AGCAAGCGCA GGAACAACAG          #                   #          870 (2) INFORMATION FOR SEQ ID NO: 187:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 18 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #187: Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gl #n Leu Leu Val Arg Pr 1               5    #                10   #                15 Ala Met (2) INFORMATION FOR SEQ ID NO: 188:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 18 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #188: Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #y Gly Ser Gly Gly Gly 1               5    #                10   #                15 Ser Asn (2) INFORMATION FOR SEQ ID NO: 189:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 18 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #189: Tyr Val Ile Glu Gly Lys Ile Ser Pro Gly Gl #y Gly Ser Gly Gly Gly 1               5    #                10   #                15 Ser Asn (2) INFORMATION FOR SEQ ID NO: 190:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 18 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #190: Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gl #y Gly Ser Gly Gly Gly 1               5    #                10   #                15 Ser Asn (2) INFORMATION FOR SEQ ID NO: 191:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 33 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #191: Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #u Pro Ser Gly Pro Ile 1               5    #                10   #                15 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pro             20       #            25       #            30 Asn (2) INFORMATION FOR SEQ ID NO: 192:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 33 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #192: Tyr Val Ile Glu Gly Lys Ile Ser Pro Gly Gl #u Pro Ser Gly Pro Ile 1               5    #                10   #                15 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pro             20       #            25       #            30 Asn (2) INFORMATION FOR SEQ ID NO: 193:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 33 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #193: Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gl #u Pro Ser Gly Pro Ile 1               5    #                10   #                15 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Gl #u Ser His Lys Ser Pro             20       #            25       #            30 Asn (2) INFORMATION FOR SEQ ID NO: 194:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 49 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #194: Tyr Val Ile Glu Gly Arg Ile Ser Pro Gly Gl #y Gly Ser Gly Gly Gly 1               5    #                10   #                15 Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Gl #u Gly Gly Gly Ser Glu             20       #            25       #            30 Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gl #y Gly Ser Gly Ser Gly         35           #        40           #        45 Asn (2) INFORMATION FOR SEQ ID NO: 195:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 60 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #195: Tyr Val Ile Glu Gly Arg Ile Ser Pro Gln Pr #o Pro Val Asn Ala Gly 1               5    #                10   #                15 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Se #r Glu Gly Gly Gly Ser             20       #            25       #            30 Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gl #u Gly Gly Gly Ser Gly         35           #        40           #        45 Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr Gl #u Asn     50               #    55               #    60 (2) INFORMATION FOR SEQ ID NO: 196:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 22 amino  #acids           (B) TYPE: amino acid           (C) STRANDEDNESS: <Unkno #wn>           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: peptide     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #196: Glu Phe His Ala Tyr Val Glu Gly Gly Gly Gl #y Ser Pro Gly Gly Gly 1               5    #                10   #                15 Ser Gly Gly Gly Ser Asn             20 (2) INFORMATION FOR SEQ ID NO: 197:      (i) SEQUENCE CHARACTERISTICS:           (A) LENGTH: 408 base  #pairs           (B) TYPE: nucleic acid           (C) STRANDEDNESS: double           (D) TOPOLOGY: linear     (ii) MOLECULE TYPE: DNA other nucleic  #acid           (A) DESCRIPTION: /desc  #= “synthetic DNA”     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:  #197 ATGGCTCCAA TGACTCAGAC TACTTCTCTT AAGACTTCTT GGGTTAACTG CT #CTAACATG     60 ATCGATGAAA TTATAACACA CTTAAAGCAG CCACCTTTGC CTTTGCTGGA CT #TCAACAAC    120 CTCAATGGGG AAGACCAAGA CATTCTGATG GAAAATAACC TTCGAAGGCC AA #ACCTGGAG    180 GCATTCAACA GGGCTGTCAA GAGTTTACAG AATGCATCAG CAATTGAGAG CA #TTCTTAAA    240 AATCTCCTGC CATGTCTGCC CCTGGCCACG GCCGCACCCA CGCGACATCC AA #TCCATATC    300 AAGGACGGTG ACTGGAATGA ATTCCGTCGT AAACTGACCT TCTATCTGAA AA #CCTTGGAG    360 AACGCGCAGG CTCAACAGAC CACTCTGTCG CTAGCGATCT TTTAATAA   #               408

Claims

1. A method for ex vivo expansion of stem cells, comprising the steps of;

(a) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 1

wherein

Xaa at position 17 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

Xaa at position 18 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

Xaa at position 19 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

Xaa at position 20 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

Xaa at position 21 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

Xaa at position 22 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val or Gly;

Xaa at position 23 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

Xaa at position 24 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

Xaa at position 25 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

Xaa at position 26 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

Xaa at position 27 is Leu, Gly, Arg, Thr, Ser, or Ala;

Xaa at position 28 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

Xaa at position 29 is Gln, Asn, Leu, Pro, Arg, or Val;

Xaa at position 30 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

Xaa at position 31 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

Xaa at position 32 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

Xaa at position 33 is Pro, Leu, Gln, Ala, Thr, or Glu;

Xaa at position 34 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

Xaa at position 35 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

Xaa at position 36 is Asp, Leu, or Val;

Xaa at position 37 is Phe, Ser, Pro, Trp, or Ile;

Xaa at position 38 is Asn, or Ala;

Xaa at position 40 is Leu, Trp, or Arg;

Xaa at position 41 is Asn, Cys, Arg, Leu, His, Met, or Pro;

Xaa at position 42 is Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met or Ala;

Xaa at position 43 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

Xaa at position 44 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

Xaa at position 45 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu or His;

Xaa at position 46 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

Xaa at position 47 is Ile, Gly, Val, Ser, Arg, Pro, or His;

Xaa at position 48 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

Xaa at position 49 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

Xaa at position 50 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

Xaa at position 51 is Asn, Arg, Met, Pro, Ser, Thr, or His;

Xaa at position 52 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

Xaa at position 53 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

Xaa at position 54 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

Xaa at position 55 is Arg, Thr, Val, Ser, Leu, or Gly;

Xaa at position 56 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

Xaa at position 57 is Asn or Gly;

Xaa at position 58 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

Xaa at position 59 is Glu, Tyr, His, Leu, Pro, or Arg;

Xaa at position 60 is Ala, Ser, Pro, Tyr, Asn, or Thr;

Xaa at position 61 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

Xaa at position 62 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

Xaa at position 63 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

Xaa at position 64 is Ala, Asn, Pro, Ser, or Lys;

Xaa at position 65 is Val, Thr, Pro, His, Leu, Phe, or Ser;

Xaa at position 66 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

Xaa at position 67 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

Xaa at position 68 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

Xaa at position 69 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

Xaa at position 70 is Asn, Leu, Val, Trp, Pro, or Ala;

Xaa at position 71 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

Xaa at position 72 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

Xaa at position 73 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

Xaa at position 74 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

Xaa at position 75 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

Xaa at position 76 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

Xaa at position 77 is Ile, Ser, Arg, Thr, or Leu;

Xaa at position 78 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

Xaa at position 79 is Lys, Thr, Asn, Met, Arg, Ile, Gly, or Asp;

Xaa at position 80 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

Xaa at position 81 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

Xaa at position 82 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

Xaa at position 83 is Pro, Ala, Thr, Trp, Arg, or Met;

Xaa at position 84 is Cys, Glu, Gly, Arg, Met, or Val;

Xaa at position 85 is Leu, Asn, Val, or Gln;

Xaa at position 86 is Pro, Cys, Arg, Ala, or Lys;

Xaa at position 87 is Leu, Ser, Trp, or Gly;

Xaa at position 88 is Ala, Lys, Arg, Val, or Trp;

Xaa at position 89 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

Xaa at position 90 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

Xaa at position 91 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

Xaa at position 92 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

Xaa at position 93 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

Xaa at position 94 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala, or Pro;

Xaa at position 95 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile, or Tyr;

Xaa at position 96 is Pro, Lys, Tyr, Glu, Ile, or Thr;

Xaa at position 97 is Ile, Val, Lys, Ala, or Asn;

Xaa at position 98 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

Xaa at position 99 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

Xaa at position 100 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, or Pro;

Xaa at position 101 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu, or Gln;

Xaa at position 102 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

Xaa at position 103 is Asp, or Ser;

Xaa at position 104 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

Xaa at position 105 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

Xaa at position 106 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

Xaa at position 108 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala or Pro;

Xaa at position 109 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

Xaa at position 110 is Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser, or Trp;

Xaa at position 111 is Leu, Ile, Arg, Asp, or Met;

Xaa at position 112 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

Xaa at position 113 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

Xaa at position 114 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

Xaa at position 115 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

Xaa at position 116 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

Xaa at position 117 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

Xaa at position 118 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

Xaa at position 119 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

Xaa at position 120 is Asn, Ala, Pro, Leu, His, Val, or Gln;

Xaa at position 121 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

Xaa at position 122 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

Xaa at position 123 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

wherein from 1 to 14 amino acids can be deleted from the N-terminus and/or from 1 to 15 amino acids can be deleted from the C-terminus of said human interleukin-3 mutant polypeptide; and wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding amino acids of native (1-133) human interleukin-3;

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be immediately preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(b) harvesting said cultured stem cells.

2. A method for ex vivo expansion of stem cells, comprising the steps of;

(a) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 4

wherein

Xaa at position 3 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

Xaa at position 4 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

Xaa at position 5 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

Xaa at position 6 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

Xaa at position 7 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

Xaa at position 8 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val, or Gly;

Xaa at position 9 is Ile, Val, Ala, Gly, Trp, Lys, Phe, Ser, or Arg;

Xaa at position 10 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

Xaa at position 11 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

Xaa at position 12 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

Xaa at position 13 is Leu, Gly, Arg, Thr, Ser, or Ala;

Xaa at position 14 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

Xaa at position 15 is Gln, Asn, Leu, Pro, Arg, or Val;

Xaa at position 16 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

Xaa at position 17 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

Xaa at position 18 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

Xaa at position 19 is Pro, Leu, Gln, Ala, Thr, or Glu;

Xaa at position 20 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

Xaa at position 21 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

Xaa at position 22 is Asp, Leu, or Val;

Xaa at position 23 is Phe, Ser, Pro, Trp, or Ile;

Xaa at position 24 is Asn, or Ala;

Xaa at position 26 is Leu, Trp, or Arg;

Xaa at position 27 is Asn, Cys, Arg, Leu, His, Met, Pro;

Xaa at position 28 is Gly, Asp, Ser, Cys, Ala, Lys, Asn, Thr, Leu, Val, Glu, Phe, Tyr, Ile or Met;

Xaa at position 29 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

Xaa at position 30 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

Xaa at position 31 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Asp, Asn, Arg, Ser, Ala, Ile, Glu, His or Trp;

Xaa at position 32 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

Xaa at position 33 is Ile, Gly, Val, Ser, Arg, Pro, or His;

Xaa at position 34 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

Xaa at position 35 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

Xaa at position 36 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

Xaa at position 37 is Asn, Arg, Met, Pro, Ser, Thr, or His;

Xaa at position 38 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

Xaa at position 39 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

Xaa at position 40 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

Xaa at position 41 is Arg, Thr, Val, Ser, Leu, or Gly;

Xaa at position 42 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

Xaa at position 43 is Asn or Gly;

Xaa at position 44 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

Xaa at position 45 is Glu, Tyr, His, Leu, Pro, or Arg;

Xaa at position 46 is Ala, Ser, Pro, Tyr, Asn, or Thr;

Xaa at position 47 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

Xaa at position 48 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

Xaa at position 49 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

Xaa at position 50 is Ala, Asn, Pro, Ser, or Lys;

Xaa at position 51 is Val, Thr, Pro, His, Leu, Phe, or Ser;

Xaa at position 52 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

Xaa at position 53 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

Xaa at position 54 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

Xaa at position 55 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

Xaa at position 56 is Asn, Leu, Val, Trp, Pro, or Ala;

Xaa at position 57 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

Xaa at position 58 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

Xaa at position 59 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

Xaa at position 60 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

Xaa at position 61 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or, Leu;

Xaa at position 62 is Ser, Val, Ala, Asp, Trp, Glu, Pro, Gly, or Asp;

Xaa at position 63 is Ile, Ser, Arg, Thr, or Leu;

Xaa at position 64 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

Xaa at position 65 is Lys, Thr, Gly, Asn, Met, Arg, Ile, or Asp;

Xaa at position 66 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

Xaa at position 67 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

Xaa at position 68 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

Xaa at position 69 is Pro, Ala, Thr, Trp, Arg, or Met;

Xaa at position 70 is Cys, Glu, Gly, Arg, Met, or Val;

Xaa at position 71 is Leu, Asn, Val, or Gln;

Xaa at position 72 is Pro, Cys, Arg, Ala, or Lys;

Xaa at position 73 is Leu, Ser, Trp, or Gly;

Xaa at position 74 is Ala, Lys, Arg, Val, or Trp;

Xaa at position 75 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

Xaa at position 76 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

Xaa at position 77 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

Xaa at position 78 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

Xaa at position 79 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

Xaa at position 80 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala or Pro;

Xaa at position 81 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile or Tyr;

Xaa at position 82 is Pro, Lys, Tyr, Gly, Ile, or Thr;

Xaa at position 83 is Ile, Val, Lys, Ala, or Asn;

Xaa at position 84 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

Xaa at position 85 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

Xaa at position 86 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, Pro;

Xaa at position 87 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu or Gln;

Xaa at position 88 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

Xaa at position 89 is Asp, or Ser;

Xaa at position 90 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

Xaa at position 91 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

Xaa at position 92 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

Xaa at position 94 is Arg, Lys, Asp, ].eu, Thr, Ile, Gln, His, Ser, Ala, or Pro;

Xaa at position 95 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

Xaa at position 96 is Lys, Asn, Thr, Leu, Gln, Arg, His, Glu, Ser, Ala or Trp;

Xaa at position 97 is Leu, Ile, Arg, Asp, or Met;

Xaa at position 98 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

Xaa at position 99 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

Xaa at position 100 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

Xaa at position 101 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

Xaa at position 102 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

Xaa at position 103 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

Xaa at position 104 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

Xaa at position 105 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

Xaa at position 106 is Asn, Ala, Pro, Leu, His, Val, or Gln;

Xaa at position 107 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

Xaa at position 108 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

Xaa at position 109 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding native amino acids of (1-133) human interleukin-3;

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be immediately preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(b) harvesting said cultured stem cells.

3. A method for ex vivo expansion of stem cells, comprising the steps of;

(a) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 7

wherein m is 0 or 1; Xaa at position 18 is Asn or Ile; Xaa at position 19 is Met, Ala or Ile; Xaa at position 20 is Ile, Pro or Leu; Xaa at position 23 is Ile, Ala or Leu; Xaa at position 25 is Thr or His; Xaa at position 29 is Gln, Arg, Val or Leu; Xaa at position 32 is Leu, Ala, Asn or Arg; Xaa at position 34 is Leu or Ser; Xaa at position 37 is Phe, Pro, or Ser; Xaa at position 38 is Asn or Ala; Xaa at position 42 is Gly, Ala, Ser, Asp or Asn; Xaa at position 45 is Gln, Val, or Met; Xaa at position 46 is Asp or Ser; Xaa at position 49 is Met, Ile, Leu or Asp; Xaa at position 50 is Glu or Asp; Xaa at position 51 is Asn Arg or Ser; Xaa at position 55 is Arg, Leu, or Thr; Xaa at position 56 is Pro or Ser; Xaa at position 59 is Glu or Leu; Xaa at position 60 is Ala or Ser; Xaa at position 62 is Asn, Val or Pro; Xaa at position 63 is Arg or His; Xaa at position 65 is Val or Ser; Xaa at position 67 is Ser, Asn, His or Gly; Xaa at position 69 is Gln or Glu; Xaa at position 73 is Ala or Gly; Xaa at position 76 is Ser, Ala or Pro; Xaa at position 79 is Lys, Arg or Ser; Xaa at position 82 is Leu, Glu, Val or Trp; Xaa at position 85 is Leu or Val; Xaa at position 87 is Leu, Ser, Trp; Xaa at position 88 is Ala or Trp; Xaa at position 91 is Ala or Pro; Xaa at position 93 is Pro or Ser; Xaa at position 95 is His or Thr; Xaa at position 98 is His, Ile, or Thr; Xaa at position 100 is Lys or Arg; Xaa at position 101 is Asp, Ala or Met; Xaa at position 105 is Asn or Gln; Xaa at position 109 is Arg, Glu or Leu; Xaa at position 112 is Thr or Gln; Xaa at position 116 is Lys, Val, Trp or Ser; Xaa at position 117 is Thr or Ser; Xaa at position 120 is Asn, Gln, or His; Xaa at position 123 is Ala or Glu; with the proviso that from four to forty-four of the amino acids designated by Xaa are different from the corresponding amino acids of native human interleukin-3);

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be immediately preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(b) harvesting said cultured stem cells.

4. A method for ex vivo expansion of stem cells, comprising the steps of;

(a) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 8

wherein m is 0 or 1; n is 0 or 1; p is 0 or 1; Xaa at position 4 is Asn or Ile; Xaa at position 5 is Met, Ala or Ile: Xaa at position 6 is Ile, Pro or Leu; Xaa at position 9 is Ile, Ala or Leu; Xaa at position 11 is Thr or His; Xaa at position 15 is Gln, Arg, Val or Leu; Xaa at position 18 is Leu, Ala, Asn or Arg; Xaa at position 20 is Leu or Ser; Xaa at position 23 is Phe, Pro, or Ser; Xaa at position 24 is Asn or Ala; Xaa at position 28 is Gly, Ala, Ser, Asp or Asn; Xaa at position 31 is Gln, Val, or Met; Xaa at position 32 is Asp or Ser; Xaa at position 35 is Met, Ile, Leu or Asp; Xaa at position 36 is Glu or Asp; Xaa at position 37 is Asn, Arg or Ser; Xaa at position 41 is Arg, Leu, or Thr; Xaa at position 42 is Pro or Ser; Xaa at position 45 is Glu or Leu; Xaa at position 46 is Ala or Ser; Xaa at position 48 is Asn, Val or Pro; Xaa at position 49 is Arg or His; Xaa at position 51 is Val or Ser; Xaa at position 53 is Ser, Asn, His or Gly; Xaa at position 55 is Gln or Glu; Xaa at position 59 is Ala or Gly; Xaa at position 62 is Ser, Ala or Pro; Xaa at position 65 is Lys, Arg or Ser; Xaa at position 67 is Leu, Glu, or Val; Xaa at position 68 is Leu, Glu, Val or Trp; Xaa at position 71 is Leu or Val; Xaa at position 73 is Leu, Ser or Trp; Xaa at position 74 is Ala or Trp; Xaa at position 77 is Ala or Pro; Xaa at position 79 is Pro or Ser; Xaa at position 81 is His or Thr; Xaa at position 84 is His, Ile, or Thr; Xaa at position 86 is Lys or Arg; Xaa at position 87 is Asp, Ala or Met; Xaa at position 91 is Asn or Glu; Xaa at position 95 is Arg, Glu, Leu; Xaa at position 98 Thr or Gln; Xaa at position 102 is Lys, Val, Trp or Ser; Xaa at position 103 is Thr or Ser; Xaa at position 106 is Asn, Gln, or His; Xaa at position 109 is Ala or Glu; with the proviso that from four to forty-four of the amino acids designated by Xaa are different from the corresponding amino acids of native (15-125)human interleukin-3;

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be immediately preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(b) harvesting said cultured stem cells.

5. The method according to claim 2 wherein RI is selected from the group consisting of:

7 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys SEQ ID NO:9 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Tie Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys SEQ ID NO:10 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys SEQ ID NO:11 Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:12 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:13 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:14 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:16 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:17 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:18 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:19 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:20 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys SEQ ID NO:21 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln; Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys SEQ ID NO:22 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys SEQ ID NO:23 Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys SEQ ID NO:24 Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His SEQ ID NO:25 Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Gln Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Gln Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His SEQ ID NO:26 Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Gln Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Gln Gln Gln; Met Ala Asn Cys Ser Asn Met Ile Asp Gln Ile Ile Thr His SEQ ID NO:27 Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Gln Asp Gln Asp Ile Leu Met Gln Asn Asn Leu Arg Arg Pro Asn Leu Gln Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Gln Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Gln Lys Leu Thr Phe Tyr Leu Val Ser Leu Gln His Ala Gln Gln Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Gln Ile Ile His His SEQ ID NO:28 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Gln Arg Asn Leu Arg Leu Pro Asn Leu Gln Ser Phe Val Arg Ala Val Lys Asn Leu Gln Asn Ala Ser Ala Ile Gln Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Gln Asn Ala Gln Ala Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Gln Ile Ile His His SEQ ID NO:29 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:30 Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:31 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:32 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:33 Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:34 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:35 Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:36 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:37 Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:38 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:39 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:40 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Asp Arg Asn Leu Arg Leu Ser Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ala Ile His His SEQ ID NO:41 Leu Lys Arg Pro Pro Ala Pro Ser Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:42 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:43 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:44 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His SEQ ID NO:45 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp Asp Asp Asp Lys SEQ ID NO:46 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp Asp Asp Asp Lys SEQ ID NO:47 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln; and Met Ala Asn Cys Ser Ile Met Ile Asp Glu Leu Ile His His SEQ ID NO:48 Leu Lys Ile Pro Pro Asn Pro Ser Leu Asp Ser Ala Asn Leu Asn Ser Glu Asp Val Ser Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln.

6. The method of claim 1, 2, 3, 4 or 5 wherein is R2 is R1 or a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF);

7. The method of claim 6 wherein is R2 is selected from the group consisting of G-CSF, G-CSF Ser17, flt3 ligand and c-mpl ligand.

8. The method of claim 2 wherein said chimera protein is selected from group consisting of: SEQ ID NO: 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 165, 166, 167 and 168.

9. The method of claim 9 wherein said chimera protein is selected from group consisting of: SEQ ID NO: 124, SEQ ID NO: 133, SEQ ID NO: 154 and SEQ ID NO: 155.

10. The method of claim 1, 2, 3, 4, 5, 8 or 9 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

11. The method of claim 6 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

12. The method of claim 7 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

13. Cultured stem cells obtained by the method of claim 2.

14. Cultured stem cells obtained by the method of claim 8.

15. Cultured stem cells obtained by the method of claim 10.

16. The method of claim 1 wherein said mutant human interleukin-3 polypeptide has at least three times greater activity than native human interleukin-3, in at least one assay selected from the group consisting of: AML cell proliferation, TF-1 cell proliferation and Methylcellulose assay.

17. The method of claim 7 wherein said mutant human interleukin-3 polypeptide has at least three times greater activity than native human interleukin-3, in at least one assay selected from the group consisting of: AML cell proliferation, TF-1 cell proliferation and Methylcellulose assay.

18. The method of claim 1 further comprising the step of separating the stem cells from a mixed population of cells prior to culturing the stem cells.

19. The method of claim 18 wherein said stem cells are separated from a mixed population of cells based on the stem cells having CD34 surface antigen.

20. A method for treatment of a patient having a hematopoietic disorder, comprising the steps of;

(a) removing stem cells from said patient or a donor;

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein RI is a human interleukin-3 mutant polypeptide of SEQ ID NO: 1

wherein

Xaa at position 17 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

Xaa at position 18 is Asn, His, Leu, lie, Phe, Arg, or Gln;

Xaa at position 19 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

Xaa at position 20 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

Xaa at position 21 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

Xaa at position 22 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val or Gly;

Xaa at position 23 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

Xaa at position 24 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

Xaa at position 25 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

Xaa at position 26 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

Xaa at position 27 is Leu, Gly, Arg, Thr, Ser, or Ala;

Xaa at position 28 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

Xaa at position 29 is Gln, Asn, Leu, Pro, Arg, or Val;

Xaa at position 30 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

Xaa at position 31 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

Xaa at position 32 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

Xaa at position 33 is Pro, Leu, Gln, Ala, Thr, or Glu;

Xaa at position 34 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

Xaa at position 35 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

Xaa at position 36 is Asp, Leu, or Val;

Xaa at position 37 is Phe, Ser, Pro, Trp, or Ile;

Xaa at position 38 is Asn, or Ala;

Xaa at position 40 is Leu, Trp, or Arg;

Xaa at position 41 is Asn, Cys, Arg, Leu, His, Met, or Pro;

Xaa at position 42 is Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met or Ala;

Xaa at position 43 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

Xaa at position 44 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

Xaa at position 45 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu or His;

Xaa at position 46 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

Xaa at position 47 is Ile, Gly, Val, Ser, Arg, Pro, or His;

Xaa at position 48 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

Xaa at position 49 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

Xaa at position 50 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

Xaa at position 51 is Asn, Arg, Met, Pro, Ser, Thr, or His;

Xaa at position 52 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

Xaa at position 53 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

Xaa at position 54 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

Xaa at position 55 is Arg, Thr, Val, Ser, Leu, or Gly;

Xaa at position 56 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

Xaa at position 57 is Asn or Gly;

Xaa at position 58 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

Xaa at position 59 is Glu, Tyr, His, Leu, Pro, or Arg;

Xaa at position 60 is Ala, Ser, Pro, Tyr, Asn, or Thr;

Xaa at position 61 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

Xaa at position 62 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

Xaa at position 63 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

Xaa at position 64 is Ala, Asn, Pro, Ser, or Lys;

Xaa at position 65 is Val, Thr, Pro, His, Leu, Phe, or Ser;

Xaa at position 66 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

Xaa at position 67 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

Xaa at position 68 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

Xaa at position 69 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

Xaa at position 70 is Asn, Leu, Val, Trp, Pro, or Ala;

Xaa at position 71 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

Xaa at position 72 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

Xaa at position 73 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

Xaa at position 74 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

Xaa at position 75 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

Xaa at position 76 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

Xaa at position 77 is Ile, Ser, Arg, Thr, or Leu;

Xaa at position 78 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

Xaa at position 79 is Lys, Thr, Asn, Met, Arg, Ile, Gly, or Asp;

Xaa at position 80 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

Xaa at position 81 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

Xaa at position 82 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

Xaa at position 83 is Pro, Ala, Thr, Trp, Arg, or Met;

Xaa at position 84 is Cys, Glu, Gly, Arg, Met, or Val;

Xaa at position 85 is Leu, Asn, Val, or Gln;

Xaa at position 86 is Pro, Cys, Arg, Ala, or Lys;

Xaa at position 87 is Leu, Ser, Trp, or Gly;

Xaa at position 88 is Ala, Lys, Arg, Val, or Trp;

Xaa at position 89 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

Xaa at position 90 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

Xaa at position 91 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

Xaa at position 92 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

Xaa at position 93 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

Xaa at position 94 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala, or Pro;

Xaa at position 95 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile, or Tyr;

Xaa at position 96 is Pro, Lys, Tyr, Gly, Ile, or Thr;

Xaa at position 97 is Ile, Val, Lys, Ala, or Asn;

Xaa at position 98 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

Xaa at position 99 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

Xaa at position 100 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, or Pro;

Xaa at position 101 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu, or Gln;

Xaa at position 102 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

Xaa at position 103 is Asp, or Ser;

Xaa at position 104 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

Xaa at position 105 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

Xaa at position 106 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

Xaa at position 108 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala or Pro;

Xaa at position 109 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

Xaa at position 110 is Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser, or Trp;

Xaa at position 111 is Leu, Ile, Arg, Asp, or Met;

Xaa at position 112 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

Xaa at position 113 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

Xaa at position 114 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

Xaa at position 115 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

Xaa at position 116 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

Xaa at position 117 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

Xaa at position 118 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

Xaa at position 119 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

Xaa at position 120 is Asn, Ala, Pro, Leu, His, Val, or Gln;

Xaa at position 121 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

Xaa at position 122 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

Xaa at position 123 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

wherein from 1 to 14 amino acids can be deleted from the N-terminus and/or from 1 to 15 amino acids can be deleted from the C-terminus of said human interleukin-3 mutant polypeptide; and wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding amino acids of native (1-133) human interleukin-3;

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) harvesting said cultured stem cells; and

(d) transplanting said cultured stem cells into said patient.

21. A method for treatment of a patient having a hematopoietic disorder, comprising the steps of;

(a) removing stem cells from said patient or a donor;

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 4

wherein

Xaa at position 3 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

Xaa at position 4 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

Xaa at position 5 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

Xaa at position 6 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

Xaa at position 7 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

Xaa at position 8 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val, or Gly;

Xaa at position 9 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

Xaa at position 10 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

Xaa at position 11 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

Xaa at position 12 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

Xaa at position 13 is Leu, Gly, Arg, Thr, Ser, or Ala;

Xaa at position 14 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

Xaa at position 15 is Gln, Asn, Leu, Pro, Arg, or Val;

Xaa at position 16 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

Xaa at position 17 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

Xaa at position 18 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

Xaa at position 19 is Pro, Leu, Gln, Ala, Thr, or Glu;

Xaa at position 20 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

Xaa at position 21 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

Xaa at position 22 is Asp, Leu, or Val;

Xaa at position 23 is Phe, Ser, Pro, Trp, or Ile;

Xaa at position 24 is Asn, or Ala;

Xaa at position 26 is Leu, Trp, or Arg;

Xaa at position 27 is Asn, Cys, Arg, Leu, His, Met, Pro;

Xaa at position 28 is Gly, Asp, Ser, Cys, Ala, Lys, Asn, Thr, Leu, Val, Glu, Phe, Tyr, Ile or Met;

Xaa at position 29 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

Xaa at position 30 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

Xaa at position 31 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Asp, Asn, Arg, Ser, Ala, Ile, Glu, His or Trp;

Xaa at position 32 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

Xaa at position 33 is Ile, Gly, Val, Ser, Arg, Pro, or His;

Xaa at position 34 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

Xaa at position 35 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

Xaa at position 36 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

Xaa at position 37 is Asn, Arg, Met, Pro, Ser, Thr, or His;

Xaa at position 38 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

Xaa at position 39 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

Xaa at position 40 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

Xaa at position 41 is Arg, Thr, Val, Ser, Leu, or Gly;

Xaa at position 42 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

Xaa at position 43 is Asn or Gly;

Xaa at position 44 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

Xaa at position 45 is Glu, Tyr, His, Leu, Pro, or Arg;

Xaa at position 46 is Ala, Ser, Pro, Tyr, Asn, or Thr;

Xaa at position 47 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

Xaa at position 48 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

Xaa at position 49 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

Xaa at position 50 is Ala, Asn, Pro, Ser, or Lys;

Xaa at position 51 is Val, Thr, Pro, His, Leu, Phe, or Ser;

Xaa at position 52 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

Xaa at position 53 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

Xaa at position 54 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

Xaa at position 55 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

Xaa at position 56 is Asn, Leu, Val, Trp, Pro, or Ala;

Xaa at position 57 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

Xaa at position 58 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

Xaa at position 59 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

Xaa at position 60 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

Xaa at position 61 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

Xaa at position 62 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

Xaa at position 63 is Ile, Ser, Arg, Thr, or Leu;

Xaa at position 64 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

Xaa at position 65 is Lys, Thr, Gly, Asn, Met, Arg, Ile, or Asp;

Xaa at position 66 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

Xaa at position 67 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

Xaa at position 68 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

Xaa at position 69 is Pro, Ala, Thr, Trp, Arg, or Met;

Xaa at position 70 is Cys, Glu, Gly, Arg, Met, or Val;

Xaa at position 71 is Leu, Asn, Val, or Gln;

Xaa at position 72 is Pro, Cys, Arg, Ala, or Lys;

Xaa at position 73 is Leu, Ser, Trp, or Gly;

Xaa at position 74 is Ala, Lys, Arg, Val, or Trp;

Xaa at position 75 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

Xaa at position 76 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

Xaa at position 77 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

Xaa at position 78 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

Xaa at position 79 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

Xaa at position 80 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala or Pro;

Xaa at position 81 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile or Tyr;

Xaa at position 82 is Pro, Lys, Tyr, Gly, Ile, or Thr;

Xaa at position 83 is Ile, Val, Lys, Ala, or Asn;

Xaa at position 84 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

Xaa at position 85 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

Xaa at position 86 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, Pro;

Xaa at position 87 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu or Gln;

Xaa at position 88 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

Xaa at position 89 is Asp, or Ser;

Xaa at position 90 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

Xaa at position 91 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

Xaa at position 92 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

Xaa at position 94 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala, or Pro;

Xaa at position 95 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

Xaa at position 96 is Lys, Asn, Thr, Leu, Gln, Arg, His, Glu, Ser, Ala or Trp;

Xaa at position 97 is Leu, Ile, Arg, Asp, or Met;

Xaa at position 98 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

Xaa at position 99 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

Xaa at position 100 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

Xaa at position 101 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

Xaa at position 102 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

Xaa at position 103 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

Xaa at position 104 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

Xaa at position 105 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

Xaa at position 106 is Asn, Ala, Pro, Leu, His, Val, or Gln;

Xaa at position 107 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

Xaa at position 108 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

Xaa at position 109 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding native amino acids of (1-133) human interleukin-3;

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) harvesting said cultured stem cells; and

(d) transplanting said cultured stem cells into said patient.

22. A method for treatment of a patient having a hematopoietic disorder, comprising the steps of;

(a) removing stem cells from said patient or a donor;

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 7

wherein m is 0 or 1; Xaa at position 18 is Asn or Ile; Xaa at position 19 is Met, Ala or Ile; Xaa at position 20 is Ile, Pro or Leu; Xaa at position 23 is Ile, Ala or Leu; Xaa at position 25 is Thr or His; Xaa at position 29 is Gln, Arg, Val or Leu; Xaa at position 32 is Leu, Ala, Asn or Arg; Xaa at position 34 is Leu or Ser; Xaa at position 37 is Phe, Pro, or Ser; Xaa at position 38 is Asn or Ala; Xaa at position 42 is Gly, Ala, Ser, Asp or Asn; Xaa at position 45 is Gln, Val, or Met; Xaa at position 46 is Asp or Ser; Xaa at position 49 is Met, Ile, Leu or Asp; Xaa at position 50 is Glu or Asp; Xaa at position 51 is Asn Arg or Ser; Xaa at position 55 is Arg, Leu, or Thr; Xaa at position 56 is Pro or Ser; Xaa at position 59 is Glu or Leu; Xaa at position 60 is Ala or Ser; Xaa at position 62 is Asn, Val or Pro; Xaa at position 63 is Arg or His; Xaa at position 65 is Val or Ser; Xaa at position 67 is Ser, Asn, His or Gly; Xaa at position 69 is Gln or Glu; Xaa at position 73 is Ala or Gly; Xaa at position 76 is Ser, Ala or Pro; Xaa at position 79 is Lys, Arg or Ser; Xaa at position 82 is Leu, Glu, Val or Trp; Xaa at position 85 is Leu or Val; Xaa at position 87 is Leu, Ser, Trp; Xaa at position 88 is Ala or Trp; Xaa at position 91 is Ala or Pro; Xaa at position 93 is Pro or Ser; Xaa at position 95 is His or Thr; Xaa at position 98 is His, Ile, or Thr; Xaa at position 100 is Lys or Arg; Xaa at position 101 is Asp, Ala or Met; Xaa at position 105 is Asn or Gln; Xaa at position 109 is Arg, Glu or Leu; Xaa at position 112 is Thr or Gln; Xaa at position 116 is Lys, Val, Trp or Ser; Xaa at position 117 is Thr or Ser; Xaa at position 120 is Asn, Gln, or His; Xaa at position 123 is Ala or Glu; with the proviso that from four to forty-four of the amino acids designated by Xaa are different from the corresponding amino acids of native human interleukin-3);

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1);and

(c) harvesting said cultured stem cells; and

(d) transplanting said cultured stem cells into said patient.

23. A method for treatment of a patient having a hematopoietic disorder, comprising the steps of;

(a) removing stem cells from said patient or a donor;

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 8

wherein m is 0 or 1; n is 0 or 1; p is 0 or 1; Xaa at position 4 is Asn or Ile; Xaa at position 5 is Met, Ala or Ile: Xaa at position 6 is Ile, Pro or Leu; Xaa at position 9 is Ile, Ala or Leu; Xaa at position 11 is Thr or His; Xaa at position 15 is Gln, Arg, Val or Leu; Xaa at position 18 is Leu, Ala, Asn or Arg; Xaa at position 20 is Leu or Ser; Xaa at position 23 is Phe, Pro, or Ser; Xaa at position 24 is Asn or Ala; Xaa at position 28 is Gly, Ala, Ser, Asp or Asn; Xaa at position 31 is Gln, Val, or Met; Xaa at position 32 is Asp or Ser; Xaa at position 35 is Met, Ile, Leu or Asp; Xaa at position 36 is Glu or Asp; Xaa at position 37 is Asn, Arg or Ser; Xaa at position 41 is Arg, Leu, or Thr; Xaa at position 42 is Pro or Ser; Xaa at position 45 is Glu or Leu; Xaa at position 46 is Ala or Ser; Xaa at position 48 is Asn, Val or Pro; Xaa at position 49 is Arg or His; Xaa at position 51 is Val or Ser; Xaa at position 53 is Ser, Asn, His or Gly; Xaa at position 55 is Gln or Glu; Xaa at position 59 is Ala or Gly; Xaa at position 62 is Ser, Ala or Pro; Xaa at position 65 is Lys, Arg or Ser; Xaa at position 67 is Leu, Glu, or Val; Xaa at position 68 is Leu, Glu, Val or Trp; Xaa at position 71 is Leu or Val; Xaa at position 73 is Leu, Ser or Trp; Xaa at position 74 is Ala or Trp; Xaa at position 77 is Ala or Pro; Xaa at position 79 is Pro or Ser; Xaa at position 81 is His or Thr; Xaa at position 84 is His, Ile, or Thr; Xaa at position 86 is Lys or Arg; Xaa at position 87 is Asp, Ala or Met; Xaa at position 91 is Asn or Glu; Xaa at position 95 is Arg, Glu, Leu; Xaa at position 98 Thr or Gln; Xaa at position 102 is Lys, Val, Trp or Ser; Xaa at position 103 is Thr or Ser; Xaa at position 106 is Asn, Gln, or His; Xaa at position 109 is Ala or Glu; with the proviso that from four to forty-four of the amino acids designated by Xaa are different from the corresponding amino acids of native (15-125)human interleukin-3;

R2 is a hematopoietic growth factor;

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) harvesting said cultured stem cells; and

(d) transplanting said cultured stem cells into said patient.

24. The method according to claim 1 wherein R1 is selected from the group consisting of:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 9;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 10;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 11;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 12;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 13;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 14;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu. Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu. Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 15;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala. Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 16;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 17;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 18;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 19;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 20;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 21;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 22;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 23;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gin Gin SEQ ID NO: 24;

Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 25;

Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 26;

Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 27;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 28;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 29;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 30;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 31;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 32;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 33;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 34;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 35;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 36;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 37;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 38;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 39;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Asp Arg Asn Leu Arg Leu Ser Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 40;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ala Ile His His Leu Lys Arg Pro Pro Ala Pro Ser Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 41;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 42;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 43;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 44;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 45;

Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp Asp Asp Asp Lys Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 46;

Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp Asp Asp Asp Lys Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 47; and

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Leu Ile His His Leu Lys Ile Pro Pro Asn Pro Ser Leu Asp Ser Ala Asn Leu Asn Ser Glu Asp Val Ser Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 48.

25. The method of claim 20, 21, 22, 23 or 24 wherein is R2 is R1 or a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

26. The method of claim 25 wherein is R2 is selected from the group consisting of G-CSF, G-CSF Ser17, flt3 ligand and c-mpl ligand.

27. The method of claim 21 wherein said chimera protein is selected from group consisting of: SEQ ID NO: 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 165, 166, 167 and 168.

28. The method of claim 28 wherein said chimera protein is selected from group consisting of: SEQ ID NO: 124, SEQ ID NO: 133, SEQ ID NO: 154 and SEQ ID NO: 155.

29. The method of claim 20, 21, 22, 23, 24, 27 or 28 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

30. The method of claim 25 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

31. The method of claim 26 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

32. The method of claim 20 wherein said mutant human interleukin-3 polypeptide has at least three times greater activity than native human interleukin-3, in at least one assay selected from the group consisting of: AML cell proliferation, TF-1 cell proliferation and Methylcellulose assay.

33. The method of claim 25 wherein said mutant human interleukin-3 polypeptide has at least three times greater activity than native human interleukin-3, in at least one assay selected from the group consisting of: AML cell proliferation, TF-1 cell proliferation and Methylcellulose assay.

34. The method of claim 20 further comprising the step of separating the stem cells from a mixed population of cells prior to culturing the stem cells.

35. The method of claim 34 wherein said stem cells are separated from a mixed population of cells based on the stem cells having CD34 surface antigen.

36. A method of human gene therapy, comprising the steps of;

(a) removing stem cells from a patient or donor

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 1

wherein

Xaa at position 17 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

Xaa at position 18 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

Xaa at position 19 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

Xaa at position 20 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

Xaa at position 21 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

Xaa at position 22 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val or Gly;

Xaa at position 23 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

Xaa at position 24 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

Xaa at position 25 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

Xaa at position 26 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

Xaa at position 27 is Leu, Gly, Arg, Thr, Ser, or Ala;

Xaa at position 28 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

Xaa at position 29 is Gln, Asn, Leu, Pro, Arg, or Val;

Xaa at position 30 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

Xaa at position 31 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

Xaa at position 32 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

Xaa at position 33 is Pro, Leu, Gln, Ala, Thr, or Glu;

Xaa at position 34 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

Xaa at position 35 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

Xaa at position 36 is Asp, Leu, or Val;

Xaa at position 37 is Phe, Ser, Pro, Trp, or Ile;

Xaa at position 38 is Asn, or Ala;

Xaa at position 40 is Leu, Trp, or Arg;

Xaa at position 41 is Asn, Cys, Arg, Leu, His, Met, or Pro;

Xaa at position 42 is Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met or Ala;

Xaa at position 43 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

Xaa at position 44 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

Xaa at position 45 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu or His;

Xaa at position 46 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

Xaa at position 47 is Ile, Gly, Val, Ser, Arg, Pro, or His;

Xaa at position 48 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

Xaa at position 49 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

Xaa at position 50 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

Xaa at position 51 is Asn, Arg, Met, Pro, Ser, Thr, or His;

Xaa at position 52 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

Xaa at position 53 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

Xaa at position 54 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

Xaa at position 55 is Arg, Thr, Val, Ser, Leu, or Gly;

Xaa at position 56 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

Xaa at position 57 is Asn or Gly;

Xaa at position 58 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

Xaa at position 59 is Glu, Tyr, His, Leu, Pro, or Arg;

Xaa at position 60 is Ala, Ser, Pro, Tyr, Asn, or Thr;

Xaa at position 61 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

Xaa at position 62 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

Xaa at position 63 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

Xaa at position 64 is Ala, Asn, Pro, Ser, or Lys;

Xaa at position 65 is Val, Thr, Pro, His, Leu, Phe, or Ser;

Xaa at position 66 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

Xaa at position 67 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

Xaa at position 68 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

Xaa at position 69 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

Xaa at position 70 is Asn, Leu, Val, Trp, Pro, or Ala;

Xaa at position 71 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

Xaa at position 72 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

Xaa at position 73 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

Xaa at position 74 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

Xaa at position 75 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

Xaa at position 76 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

Xaa at position 77 is Ile, Ser, Arg, Thr, or Leu;

Xaa at position 78 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

Xaa at position 79 is Lys, Thr, Asn, Met, Arg, Ile, Gly, or Asp;

Xaa at position 80 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

Xaa at position 81 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

Xaa at position 82 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

Xaa at position 83 is Pro, Ala, Thr, Trp, Arg, or Met;

Xaa at position 84 is Cys, Glu, Gly, Arg, Met, or Val;

Xaa at position 85 is Leu, Asn, Val, or Gln;

Xaa at position 86 is Pro, Cys, Arg, Ala, or Lys;

Xaa at position 87 is Leu, Ser, Trp, or Gly;

Xaa at position 88 is Ala, Lys, Arg, Val, or Trp;

Xaa at position 89 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

Xaa at position 90 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

Xaa at position 91 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

Xaa at position 92 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

Xaa at position 93 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

Xaa at position 94 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala, or Pro;

Xaa at position 95 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile, or Tyr;

Xaa at position 96 is Pro, Lys, Tyr, Gly, Ile, or Thr;

Xaa at position 97 is Ile, Val, Lys, Ala, or Asn;

Xaa at position 98 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

Xaa at position 99 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

Xaa at position 100 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, or Pro;

Xaa at position 101 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu, or Gln;

Xaa at position 102 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

Xaa at position 103 is Asp, or Ser;

Xaa at position 104 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

Xaa at position 105 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

Xaa at position 106 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

Xaa at position 108 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala or Pro;

Xaa at position 109 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

Xaa at position 110 is Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser, or Trp;

Xaa at position 111 is Leu, Ile, Arg, Asp, or Met;

Xaa at position 112 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

Xaa at position 113 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

Xaa at position 114 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

Xaa at position 115 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

Xaa at position 116 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

Xaa at position 117 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

Xaa at position 118 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

Xaa at position 119 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

Xaa at position 120 is Asn, Ala, Pro, Leu, His, Val, or Gln;

Xaa at position 121 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

Xaa at position 122 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

Xaa at position 123 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

wherein from 1 to 14 amino acids can be deleted from the N-terminus and/or from 1 to 15 amino acids can be deleted from the C-terminus of said human interleukin-3 mutant polypeptide; and wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding amino acids of native (1-133) human interleukin-3;

R2 is a hematopoietic growth factor; and

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) transducing DNA into said cultured cells;

(d) harvesting said transduced cells; and

(e) transplanting said transduced cells into said patient.

37. A method of human gene therapy, comprising the steps of;

(a) removing stem cells from a patient or a donor;

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 4

wherein

Xaa at position 3 is Ser, Lys, Gly, Asp, Met, Gln, or Arg;

Xaa at position 4 is Asn, His, Leu, Ile, Phe, Arg, or Gln;

Xaa at position 5 is Met, Phe, Ile, Arg, Gly, Ala, or Cys;

Xaa at position 6 is Ile, Cys, Gln, Glu, Arg, Pro, or Ala;

Xaa at position 7 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser or Val;

Xaa at position 8 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val, or Gly;

Xaa at position 9 is Ile, Val, Ala, Leu, Gly, Trp, Lys, Phe, Ser, or Arg;

Xaa at position 10 is Ile, Gly, Val, Arg, Ser, Phe, or Leu;

Xaa at position 11 is Thr, His, Gly, Gln, Arg, Pro, or Ala;

Xaa at position 12 is His, Thr, Phe, Gly, Arg, Ala, or Trp;

Xaa at position 13 is Leu, Gly, Arg, Thr, Ser, or Ala;

Xaa at position 14 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp;

Xaa at position 15 is Gln, Asn, Leu, Pro, Arg, or Val;

Xaa at position 16 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or Lys;

Xaa at position 17 is Pro, Asp, Gly, Ala, Arg, Leu, or Gln;

Xaa at position 18 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu;

Xaa at position 19 is Pro, Leu, Gln, Ala, Thr, or Glu;

Xaa at position 20 is Leu, Val, Gly,. Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met;

Xaa at position 21 is Leu, Ala, Gly, Asn, Pro, Gln, or Val;

Xaa at position 22 is Asp, Leu, or Val;

Xaa at position 23 is Phe, Ser, Pro, Trp, or Ile;

Xaa at position 24 is Asn, or Ala;

Xaa at position 26 is Leu, Trp, or Arg;

Xaa at position 27 is Asn, Cys, Arg, Leu, His, Met, Pro;

Xaa at position 28 is Gly, Asp, Ser. Cys, Ala, Lys, Asn, Thr, Leu, Val, Glu, Phe, Tyr, Ile or Met;

Xaa at position 29 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly or Ser;

Xaa at position 30 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro;

Xaa at position 31 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Asp, Asn, Arg, Ser, Ala, Ile, Glu, His or Trp;

Xaa at position 32 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly;

Xaa at position 33 is Ile, Gly, Val, Ser, Arg, Pro, or His;

Xaa at position 34 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn;

Xaa at position 35 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp;

Xaa at position 36 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln;

Xaa at position 37 is Asn, Arg, Met, Pro, Ser, Thr, or His;

Xaa at position 38 is Asn, His, Arg, Leu, Gly, Ser, or Thr;

Xaa at position 39 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or Met;

Xaa at position 40 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu;

Xaa at position 41 is Arg, Thr, Val, Ser, Leu, or Gly;

Xaa at position 42 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys;

Xaa at position 43 is Asn or Gly;

Xaa at position 44 is Leu, Ser, Asp, Arg, Gln, Val, or Cys;

Xaa at position 45 is Glu, Tyr, His, Leu, Pro, or Arg;

Xaa at position 46 is Ala, Ser, Pro, Tyr, Asn, or Thr;

Xaa at position 47 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser;

Xaa at position 48 is Asn, His, Val, Arg, Pro, Thr, Asp, or Ile;

Xaa at position 49 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val;

Xaa at position 50 is Ala, Asn, Pro, Ser, or Lys;

Xaa at position 51 is Val, Thr, Pro, His, Leu, Phe, or Ser;

Xaa at position 52 is Lys, Ile, Arg, Val, Asn, Glu, or Ser;

Xaa at position 53 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His;

Xaa at position 54 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His;

Xaa at position 55 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly, or Leu;

Xaa at position 56 is Asn, Leu, Val, Trp, Pro, or Ala;

Xaa at position 57 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn;

Xaa at position 58 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp;

Xaa at position 59 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg;

Xaa at position 60 is Ile, Met, Thr, Pro, Arg, Gly, Ala;

Xaa at position 61 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu;

Xaa at position 62 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or Asp;

Xaa at position 63 is Ile, Ser, Arg, Thr, or Leu;

Xaa at position 64 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg;

Xaa at position 65 is Lys, Thr, Gly, Asn, Met, Arg, Ile, or Asp;

Xaa at position 66 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg;

Xaa at position 67 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys;

Xaa at position 68 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met or Val;

Xaa at position 69 is Pro, Ala, Thr, Trp, Arg, or Met;

Xaa at position 70 is Cys, Glu, Gly, Arg, Met, or Val;

Xaa at position 71 is Leu, Asn, Val, or Gln;

Xaa at position 72 is Pro, Cys, Arg, Ala, or Lys;

Xaa at position 73 is Leu, Ser, Trp, or Gly;

Xaa at position 74 is Ala, Lys, Arg, Val, or Trp;

Xaa at position 75 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or Ser;

Xaa at position 76 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met;

Xaa at position 77 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His;

Xaa at position 78 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu;

Xaa at position 79 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg;

Xaa at position 80 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala or Pro;

Xaa at position 81 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile or Tyr;

Xaa at position 82 is Pro, Lys, Tyr, Gly, Ile, or Thr;

Xaa at position 83 is Ile, Val, Lys, Ala, or Asn;

Xaa at position 84 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr or Pro;

Xaa at position 85 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His;

Xaa at position 86 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, Pro;

Xaa at position 87 is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu or Gln;

Xaa at position 88 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro;

Xaa at position 89 is Asp, or Ser;

Xaa at position 90 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly;

Xaa at position 91 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His;

Xaa at position 92 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro;

Xaa at position 94 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala, or Pro;

Xaa at position 95 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly;

Xaa at position 96 is Lys, Asn, Thr, Leu, Gln, Arg, His, Glu, Ser, Ala or Trp;

Xaa at position 97 is Leu, Ile, Arg, Asp, or Met;

Xaa at position 98 is Thr, Val, Gln, Tyr, Glu, His, Ser, or Phe;

Xaa at position 99 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn;

Xaa at position 100 is Tyr, Cys, His, Ser, Trp, Arg, or Leu;

Xaa at position 101 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met;

Xaa at position 102 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile;

Xaa at position 103 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro;

Xaa at position 104 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr;

Xaa at position 105 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg;

Xaa at position 106 is Asn, Ala, Pro, Leu, His, Val, or Gln;

Xaa at position 107 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly;

Xaa at position 108 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys;

Xaa at position 109 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu;

wherein from 4 to 44 of the amino acids designated by Xaa are different from the corresponding native amino acids of (1-133) human interleukin-3;

R2 is a hematopoietic growth factor; and

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) transducing DNA into said cultured cells;

(d) harvesting said transduced cells; and

(e) transplanting said transduced cells into said patient.

38. A method of human gene therapy, comprising the steps of;

(a) removing stem cells from a patient or a donor (b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 7

wherein m is 0 or 1; Xaa at position 18 is Asn or Ile; Xaa at position 19 is Met, Ala or Ile; Xaa at position 20 is Ile, Pro or Leu; Xaa at position 23 is Ile, Ala or Leu; Xaa at position 25 is Thr or His; Xaa at position 29 is Gln, Arg, Val or Leu; Xaa at position 32 is Leu, Ala, Asn or Arg; Xaa at position 34 is Leu or Ser; Xaa at position 37 is Phe, Pro, or Ser; Xaa at position 38 is Asn or Ala; Xaa at position 42 is Gly, Ala, Ser, Asp or Asn; Xaa at position 45 is Gin, Val, or Met; Xaa at position 46 is Asp or Ser; Xaa at position 49 is Met, Ile, Leu or Asp; Xaa at position 50 is Glu or Asp; Xaa at position 51 is Asn Arg or Ser; Xaa at position 55 is Arg, Leu, or Thr; Xaa at position 56 is Pro or Ser; Xaa at position 59 is Glu or Leu; Xaa at position 60 is Ala or Ser; Xaa at position 62 is Asn, Val or Pro; Xaa at position 63 is Arg or His; Xaa at position 65 is Val or Ser; Xaa at position 67 is Ser, Asn, His or Gly; Xaa at position 69 is Gln or Glu; Xaa at position 73 is Ala or Gly; Xaa at position 76 is Ser, Ala or Pro; Xaa at position 79 is Lys, Arg or Ser; Xaa at position 82 is Leu, Glu, Val or Trp; Xaa at position 85 is Leu or Val; Xaa at position 87 is Leu, Ser, Trp; Xaa at position 88 is Ala or Trp; Xaa at position 91 is Ala or Pro; Xaa at position 93 is Pro or Ser; Xaa at position 95 is His or Thr; Xaa at position 98 is His, Ile, or Thr; Xaa at. position 100 is Lys or Arg; Xaa at position 101 is Asp, Ala or Met; Xaa at position 105 is Asn or Gln; Xaa at position 109 is Arg, Glu or Leu; Xaa at position 112 is Thr or Gln; Xaa at position 116 is Lys, Val, Trp or Ser; Xaa at position 117 is Thr or Ser; Xaa at position 120 is Asn, Gln, or His; Xaa at position 123 is Ala or Glu; with the proviso that from four to forty-four of the amino acids designated by Xaa are different from the corresponding amino acids of native human interleukin-3;

R2 is a hematopoietic growth factor; and

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) transducing DNA into said cultured cells;

(d) harvesting said transduced cells; and

(e) transplanting said transduced cells into said patient.

39. A method of human gene therapy, comprising the steps of;

(a) removing stem cells from a patient or a donor;

(b) culturing said stem cells with a selected growth medium comprising a chimera protein having the formula selected from the group consisting of:

R1-L-R2, R2-L-R1, R1-R2, R2-R1, R1-L-R1 and R1-R1

wherein R1 is a human interleukin-3 mutant polypeptide of

wherein R1 is a human interleukin-3 mutant polypeptide of SEQ ID NO: 8

wherein m is 0 or 1; n is 0 or 1; p is 0 or 1; Xaa at position 4 is Asn or Ile; Xaa at position 5 is Met, Ala or Ile: Xaa at position 6 is lie, Pro or Leu; Xaa at position 9 is lie, Ala or Leu; Xaa at position 11 is Thr or His; Xaa at position 15 is Gln, Arg, Val or Leu; Xaa at position 18 is Leu, Ala, Asn or Arg; Xaa at position 20 is Leu or Ser; Xaa at position 23 is Phe, Pro, or Ser; Xaa at position 24 is Asn or Ala; Xaa at position 28 is Gly, Ala, Ser, Asp or Asn; Xaa at position 31 is Gln, Val, or Met; Xaa at position 32 is Asp or Ser; Xaa at position 35 is Met, Ile, Leu or Asp; Xaa at position 36 is Glu or Asp; Xaa at position 37 is Asn, Arg or Ser; Xaa at position 41 is Arg, Leu, or Thr; Xaa at position 42 is Pro or Ser; Xaa at position 45 is Glu or Leu; Xaa at position 46 is Ala or Ser; Xaa at position 48 is Asn, Val or Pro; Xaa at position 49 is Arg or His; Xaa at position 51 is Val or Ser; Xaa at position 53 is Ser, Asn, His or Gly; Xaa at position 55 is Gln or Glu; Xaa at position 59 is Ala or Gly; Xaa at position 62 is Ser, Ala or Pro; Xaa at position 65 is Lys, Arg or Ser; Xaa at position 67 is Leu, Glu, or Val; Xaa at position 68 is Leu, Glu, Val or Trp; Xaa at position 71 is Leu or Val; Xaa at position 73 is Leu, Ser or Trp; Xaa at position 74 is Ala or Trp; Xaa at position 77 is Ala or Pro; Xaa at position 79 is Pro or Ser; Xaa at position 81 is His or Thr; Xaa at position 84 is His, Ile, or Thr; Xaa at position 86 is Lys or Arg; Xaa at position 87 is Asp, Ala or Met; Xaa at position 91 is Asn or Glu; Xaa at position 95 is Arg, Glu, Leu; Xaa at position 98 Thr or Gln; Xaa at position 102 is Lys, Val, Trp or Ser; Xaa at position 103 is Thr or Ser; Xaa at position 106 is Asn, Gln, or His; Xaa at position 109 is Ala or Glu; with the proviso that from four to forty-four of the amino acids designated by Xaa are different from the corresponding amino acids of native (15-125)human interleukin-3;

R2 is a hematopoietic growth factor; and

L is a linker capable of Linking R1 to R2; and said chimera protein can additionally be preceded by (methionine−1), (alanine−1), or (methionine−2, alanine−1); and

(c) transducing DNA into said cultured cells;

(d) harvesting said transduced cells; and

(e) transplanting said transduced cells into said patient.

40. The method according to claim 39 wherein R1 is selected from the group consisting of:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu. Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn. Ala Gln Ala Gln Gln SEQ ID NO: 9;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asp Ala Gln Ala Gln Gln SEQ ID NO: 10;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 11;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 12;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 13;

Asn Cys Ser Asn Met Ile Asp Glu. Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 14;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 15;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 16;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 17;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 18;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 19;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 20;

Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 21;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 22;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 23;

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 24;

Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 25;

Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 26;

Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 27;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 28;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 29;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln SEQ ID NO: 30;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 31;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 32;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 33;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 34;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 35;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 36;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 37;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 38;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Val Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Thr Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Ser Leu Glu His Ala Gln Glu Gln Gln SEQ ID NO: 39;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Asp Arg Asn Leu Arg Leu Ser Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 40;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ala Ile His His Leu Lys Arg Pro Pro Ala Pro Ser Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 41;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 42;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 43;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 44;

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Met Ser Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 45;

Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp Asp Asp Asp Lys Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 46;

Met Ala Tyr Pro Glu Thr Asp Tyr Lys Asp Asp Asp Asp Lys Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 47; and

Met Ala Asn Cys Ser Ile Met Ile Asp Glu Leu Ile His His Leu Lys Ile Pro Pro Asn Pro Ser Leu Asp Ser Ala Asn Leu Asn Ser Glu Asp Val Ser Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln SEQ ID NO: 48.

41. The method of claim 36, 37, 38, 39, or 40 wherein is R2 is R1 or a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF);

42. The method of claim 41 wherein is R2 is selected from the group consisting of G-CSF, G-CSF Ser17, flt3 ligand or c-mpl ligand.

43. The method of claim 37 wherein said chimera protein is selected from group consisting of: SEQ ID NO: 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 165, 166, 167 and 168.

44. The method of claim 43 wherein said chimera protein is selected from group consisting of: SEQ ID NO: 124, SEQ ID NO: 133, SEQ ID NO: 154 and SEQ ID NO: 155.

45. The method of claim 37, 38, 39, 40, or 63 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

46. The method of claim 41 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), IL-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

47. The method of claim 42 wherein said culture medium further comprises a hematopoietic growth factor selected from the group consisting of: GM-CSF, CSF-1, G-CSF, G-CSF Ser17, c-mpl ligand (MGDF or TPO), M-CSF, erythropoietin (EPO), II,-1, IL-4, IL-2, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3 ligand, human growth hormone, B-cell growth factor, B-cell differentiation factor, eosinophil differentiation factor and stem cell factor (SCF).

48. The method of claim 36 wherein said mutant human interleukin-3 polypeptide has at least three times greater activity than native human interleukin-3, in at least one assay selected from the group consisting of: AML cell proliferation, TF-1 cell proliferation and Methylcellulose assay.

49. The method of claim 41 wherein said mutant human interleukin-3 polypeptide has at least three times greater activity than native human interleukin-3, in at least one assay selected from the group consisting of: AML cell proliferation, TF-1 cell proliferation and Methylcellulose assay.

50. The method of claim 36 further comprising the step of separating the stem cells from a mixed population of cells prior to culturing the stem cells.

51. The method of claim 50 wherein said stem cells are separated from a mixed population of cells based on the stem cells having CD34 surface antigen.

52. Transduced stem cells obtained by the method of claim 36.

53. Transduced stem cells obtained by the method of claim 41.

54. Transduced stem cells obtained by the method of claim 49.