Biomarkers for breast cancer

Abstract

Methods and compositions are provided for the detection of breast cancer based upon the identification of three biomarkers for non-normal breast cells. The biomarkers were identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer. Two biomarkers display increased expression in non-normal cells while the third biomarker displays decreased expression in non-normal cells.

Description

RELATED APPLICATIONS

[0001] This application is a continuation-in-part of U.S. patent applications Ser. Nos. 10/028,018, filed Dec. 21, 2001, and 10/211,015, filed Aug. 1, 2002, which are hereby incorporated in their entireties as if fully set forth.

FIELD OF THE INVENTION

[0002] The invention relates to the identification and use of gene sequences which are differentially expressed in breast cancer. In particular, the invention provides the identities of three sets of sequences that may be used to identify the presence of breast cancer in tissue and cell samples. The expression of these sequences, whether embodied in nucleic acid expression, protein expression, nucleic acid amplification and/or activation, or other formats, are used in the diagnosis and/or treatment of breast cancer as well as for the study and/or determination of prognosis of a patient. When used for diagnosis, the expression levels of these sequences are used to identify the presence of breast cancer and provide guidance as to the treatment thereof.

BACKGROUND OF THE INVENTION

[0003] Breast cancer is by far the most common cancer among women. Each year, more than 180,000 and 1 million women in the U.S. and worldwide, respectively, are diagnosed with breast cancer. Breast cancer is the leading cause of death for women between ages 50-55, and is the most common non-preventable malignancy in women in the Western Hemisphere. An estimated 2,167,000 women in the United States are currently living with the disease (National Cancer Institute, Surveillance Epidemiology and End Results (NCI SEER) program, Cancer Statistics Review (CSR), www-seer.ims.nci.nih.gov/Publications/CSR1973 (1998)). Based on cancer rates from 1995 through 1997, a report from the National Cancer Institute (NCI) estimates that about 1 in 8 women in the United States (approximately 12.8 percent) will develop breast cancer during her lifetime (NCI's Surveillance, Epidemiology, and End Results Program (SEER) publication SEER Cancer Statistics Review 1973-1997). Breast cancer is the second most common form of cancer, after skin cancer, among women in the United States. An estimated 250,100 new cases of breast cancer are expected to be diagnosed in the United States in 2001. Of these, 192,200 new cases of more advanced (invasive) breast cancer are expected to occur among women (an increase of 5% over last year), 46,400 new cases of early stage (in situ) breast cancer are expected to occur among women (up 9% from last year), and about 1,500 new cases of breast cancer are expected to be diagnosed in men (Cancer Facts & Figures 2001 American Cancer Society). An estimated 40,600 deaths (40,300 women, 400 men) from breast cancer are expected in 2001. Breast cancer ranks second only to lung cancer among causes of cancer deaths in women. Nearly 86% of women who are diagnosed with breast cancer are likely to still be alive five years later, though 24% of them will die of breast cancer after 10 years, and nearly half (47%) will die of breast cancer after 20 years.

[0004] Every woman is at risk for breast cancer. Over 70 percent of breast cancers occur in women who have no identifiable risk factors other than age (U.S. General Accounting Office. Breast Cancer, 1971-1991: Prevention, Treatment and Research. GAO/PEMD-92-12; 1991). Only 5 to 10% of breast cancers are linked to a family history of breast cancer (Henderson IC, Breast Cancer. In: Murphy G P, Lawrence W L, Lenhard R E (eds). Clinical Oncology. Atlanta, Ga.: American Cancer Society; 1995:198-219).

[0005] The relationship between the expression of cellular factors and breast cancer has been an area of interest. STK15, a centrosomal protein kinase, has been observed as frequently amplified in breast cancer, and its quantitative expression levels positively correlate with tumor grade (Zhou, H. et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20, 189-93, (1998)). RAD51 has recently been shown to interact with the tumor suppressor BRCA1 (Chen, J. J., et al. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res 59, 1752s-1756s (1999)), and its expression also positively correlates with tumor grade in breast cancer (Maacke, H. et al. Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer. Int J Cancer 88, 907-13 (2000)).

[0006] Citation of documents herein is not intended as an admission that any is pertinent prior art. All statements as to the date or representation as to the contents of documents is based on the information available to the applicant and does not constitute any admission as to the correctness of the dates or contents of the documents.

SUMMARY OF THE INVENTION

[0007] The present invention relates to the identification and use of gene sequences identified as differentially expressed in breast cancer. The sequences of two of the genes display increased expression in non-normal (or abnormal) breast cells, such as those that would be identified as atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) by standard pathology techniques based upon cytological criteria. The sequences of the third gene display decreased expression the same non-normal cells.

[0008] The first set of sequences found to be more highly expressed in non-normal breast cells are those of human cysteine-rich intestinal protein 1 (CRIP1 or hCRIP1, also known as human cysteine-rich heart protein or HCRHP). CRIP1 has been mapped to human chromosomal segment 7q11.23 (see Garcia-Barcelo et al. Genomics, 47(3):419-422, 1998).

[0009] The second set of sequences found to be more highly expressed in non-normal breast cells are those of the “hematological and neurological expressed sequence 1” (HN1 or Hn1). Murine HN1 has been identified as being expressed in mouse hemopoietic and brain tissues (see Tang et al. Mamm. Genome, 8:695-696, 1997).

[0010] The set of sequences found to be expressed at lower levels in non-normal breast cells are those expressed with a “second epithelium restricted Ets transcription factor” termed ESE-2 (see Oettgen et al., J. Biol. Chem., 274(41):29439-52, 1999). The coding region sequence of ESE-2b is identical to that of the E74 like factor 5, termed ELF5 (see Zhou et al., Oncogene, 17(21):2719-32, 1998).

[0011] The identified sequences may thus be used in methods of detecting the presence of non-normal breast cells in a tissue or cell containing sample from a subject. The presence of non-normal breast cells may also be used in methods of diagnosing the presence of breast cancer in a tissue or cell containing sample from a subject. A subject, from which a sample is taken, may be one afflicted with, or suspected of having, breast cancer.

[0012] The present invention provides a non-subjective means for detecting the presence of non-normal breast cells. This provides advantages over the use of histomorphological or cytological criteria in standard pathology techniques, which requires some level of interpretation by a pathologist trained in assessing the presence and/or progression of breast cancer. The expression levels of these sequences may also be used as a means to assay small, node negative tumors that are not readily assessed by conventional means.

[0013] The expression levels of the identified sequences may be used alone or in combination with other sequences capable of identifying the presence of non-normal cells or of various stages and/or grades of breast cancer. Preferably, the sequences of the invention are used alone or in combination with each other.

[0014] The present invention provides means for correlating a molecular expression phenotype with a physiological (cellular) stage or state of a non-normal or abnormal breast cell. This correlation provides a way to molecularly diagnose and/or monitor a cell's status in comparison to normal breast cell phenotypes as disclosed herein. Additional uses of the sequences are in the classification of cells and tissues; determination of diagnosis and/or prognosis. Use of the sequences to identify cells of a sample as non-normal or abnormal may also be used to determine the choice, or alteration, of therapy used to treat such cells in the subject from which the sample originated.

[0015] The ability to identify non-normal and abnormal breast cells is provided by the recognition of the relevancy of the level of expression of the identified sequences and not by the form of the assay used to determine the actual level of expression. An assay may utilize a means related to the expression level of the sequences disclosed herein as long as the assay reflects, quantitatively or qualitatively, expression of the sequence. Preferably, however, a quantitative assay means is preferred. Identifying features of the sequences include, but are not limited to, unique nucleic acid sequences used to encode (DNA), or express (RNA), the disclosed sequences or epitopes specific to, or activities of, proteins encoded by the sequences. Alternative means include detection of nucleic acid amplification as indicative of increased expression levels (CRIP1 and HN1 sequences) and nucleic acid inactivation, deletion, or methylation, as indicative of decreased expression levels (ESE-2 and ELF5 sequences). Stated differently, the invention may be practiced by assaying one or more aspect of the DNA template(s) underlying the expression of the disclosed sequence(s), of the RNA used as an intermediate to express the sequence(s), or of the proteinaceous product expressed by the sequence(s). As such, the detection of the amount of, stability of, or degradation (including rate) of, such DNA, RNA and proteinaceous molecules may be used in the practice of the invention.

[0016] The practice of the present invention is unaffected by the presence of minor mismatches between the disclosed sequences and those expressed by cells of a subject's sample. A non-limiting example of the existence of such mismatches are seen in cases of sequence polymorphisms between individuals of a species, such as individual human patients within Homo sapiens. Knowledge that expression of the disclosed sequences (and sequences that vary due to minor mismatches) is correlated with the presence of non-normal or abnormal breast cells and breast cancer is sufficient for the practice of the invention with an appropriate cell containing sample via an assay for expression.

[0017] In one aspect, the invention provides for the identification of the expression levels of the disclosed sequences by analysis of their expression in a sample containing breast cells. In one preferred embodiment, the sample contains single cells or homogenous cell populations which have been dissected away from, or otherwise isolated or purified from, contaminating cells beyond that possible by a simple biopsy. Multiple means for such analysis are available, including detection of expression within an assay for global, or near global, gene expression in a sample (e.g. as part of a gene expression profiling analysis such as on a microarray) or by specific detection, such as quantitative PCR or real time quantitative PCR.

[0018] Preferably, the sample is isolated via non-invasive means. The expression of the disclosed sequence(s) in the sample may be determined and compared to the expression of said sequence(s) in reference data of non-normal breast cells. Alternatively, the expression level may be compared to expression levels in normal cells, preferably from the same sample or subject.

[0019] When individual breast cells are isolated in the practice of the invention, one benefit is that contaminating, non-breast cells (such as infiltrating lymphocytes or other immune system cells) are not present to possibly affect detection of expression of the disclosed sequence(s). Such contamination is present where a biopsy is used to generate gene expression profiles.

[0020] While the present invention has been described mainly in the context of human breast cancer, it may be practiced in the context of breast cancer of an animal known to be potentially afflicted by breast cancer by use of the corresponding sequences of the animal. Preferred animals for the application of the present invention are mammals, particularly those important to agricultural applications (such as, but not limited to, cattle, sheep, horses, and other “farm animals”) and for human companionship (such as, but not limited to, dogs and cats).

BRIEF DESCRIPTION OF THE FIGURES

[0021] FIG. 1 shows log2 plots of the ratio of expression in ADH, DCIS, and IDC cells to normal cells for CRIP1 and ELF5 sequences. The horizontal line is at “0” such that the ratio is “1” and all points above the line represent increases in expression relative to normal breast cells while all points below the line represent decreases in expression relative to normal breast cells.

[0022] FIG. 2 shows the results of in situ hybridization with sense and anti-sense CRIP1 sequences to locate its expression at the cellular level in normal versus IDC cells of the same sample. CRIP1 signal localized to the epithelial cells, and its intensity was markedly increased in the IDC compartment of the same biopsy.

[0023] FIG. 3 shows the results of in situ hybridization with sense and anti-sense CRIP1 sequences to locate its expression at the cellular level in normal versus DCIS and IDC cells. CRIP1 signal again localized to the epithelial cells, and its intensity was markedly increased in non-normal cells.

DETAILED DESCRIPTION OF THE SPECIFIC EMBODIMENTS

[0024] Definitions of terms as used herein:

[0025] A “sequence” or “gene sequence” as used herein is a nucleic acid molecule or polynucleotide composed of a discrete order of nucleotide bases. The term includes the ordering of bases that encodes a discrete product (i.e. “coding region”), whether RNA or proteinaceous in nature, as well as the ordered bases that precede or follow a “coding region”. Non-limiting examples of the latter include 5′ and 3′ untranslated regions of a gene. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. It is also appreciated that alleles and polymorphisms of the disclosed sequences may exist and may be used in the practice of the invention to identify the expression level(s) of the disclosed sequences or the allele or polymorphism. Identification of an allele or polymorphism depends in part upon chromosomal location and ability to recombine during mitosis.

[0026] The terms “correlate” or “correlation” or equivalents thereof refer to an association between expression of one or more sequences and a physiologic state of a breast cell to the exclusion of one or more other states by use of the methods as described herein. The invention provides for the correlation between increases in CRIP1 and HN1 sequences and non-normal or abnormal breast cells. Similarly, the invention provides for the correlation between decreases in ESE-2/ELF5 sequences and non-normal or abnormal breast cells. Increases and decreases may be readily expressed in the form of a ratio between expression in a non-normal cell and a normal cell such that a ratio of one (1) indicates no difference while ratios of two (2) and one-half indicate twice as much, and half as much, expression in the non-normal cell versus the normal cell, respectively. Expression levels can be readily determined by quantitative methods as described below.

[0027] For example, increases in CRIP1 expression can be indicated by ratios of or about 1.1, of or about 1.2, of or about 1.3, of or about 1.4, of or about 1.5, of or about 1.6, of or about 1.7, of or about 1.8, of or about 1.9, of or about 2, of or about 2.5, of or about 3, of or about 3.5, of or about 4, of or about 4.5, of or about 5, of or about 5.5, of or about 6, of or about 6.5, of or about 7, of or about 7.5, of or about 8, of or about 8.5, of or about 9, of or about 9.5, of or about 10, of or about 15, of or about 20, of or about 30, of or about 40, of or about 50, of or about 60, of or about 70, of or about 80, of or about 90, of or about 100, of or about 150, of or about 200, of or about 300, of or about 400, of or about 500, of or about 600, of or about 700, of or about 800, of or about 900, or of or about 1000. A ratio of 2 is a 100% (or a two-fold) increase in expression. Similar ratios can be used with respect to increases in HN1 expression. Decreases in ESE-2/ELF5 expression can be indicaed by ratios of or about 0.9, of or about 0.8, of or about 0.7, of or about 0.6, of or about 0.5, of or about 0.4, of or about 0.3, of or about 0.2, of or about 0.1, of or about 0.05, of or about 0.01, of or about 0.005, of or about 0.001, of or about 0.0005, of or about 0.0001, of or about 0.00005, of or about 0.00001, of or about 0.000005, or of or about 0.000001. Non-limiting examples of such ratios are shown in FIG. 1.

[0028] A “polynucleotide” is a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides linked by phosphodiester bonds and encompasses the strand of a given sequence as disclosed herein as well as the complementary strand of a given sequence. The term refers only to the primary structure of the molecule. Thus, this term includes double- and single-stranded DNA and RNA as well as analogs thereof comprising a non-phosphodiester backbone. It also includes known types of modifications including labels known in the art, methylation, “caps”, substitution of one or more of the naturally occurring nucleotides with an analog, and internucleotide modifications such as uncharged linkages (e.g., phosphorothioates, phosphorodithioates, etc.), as well as unmodified forms of the polynucleotide.

[0029] The term “amplify” is used in the broad sense to mean creating an amplification product can be made enzymatically with DNA or RNA polymerases. “Amplification,” as used herein, generally refers to the process of producing multiple copies of a desired sequence, particularly those of a sample. “Amplification” may also be used in the context of DNA amplification wherein copies of coding sequences within the cellular genome are increased. “Multiple copies” mean at least 2 copies. A “copy” does not necessarily mean perfect sequence complementarity or identity to the template sequence. Methods for amplifying mRNA are generally known in the art, and include reverse transcription PCR (RT-PCR) and those described in U.S. patent application Ser. No. 10/062,857 entitled “Nucleic Acid Amplification” filed on Oct. 25, 2001 as well as U.S. Provisional Patent Application Nos. 60/298,847 (filed Jun. 15, 2001) and 60/257,801 (filed Dec. 22, 2000), all of which are hereby incorporated by reference in their entireties as if fully set forth.

[0030] By corresponding is meant that a nucleic acid molecule shares a substantial amount of sequence identity with another nucleic acid molecule. Substantial amount means at least 95%, usually at least 98% and more usually at least 99%, and sequence identity is determined using the BLAST algorithm, as described in Altschul et al. (1990), J. Mol. Biol. 215:403-410 (using the published default setting, i.e. parameters w=4, t=17). Alternatively, RNA may be directly labeled as the corresponding cDNA by methods known in the art.

[0031] A “microarray” is a linear or two-dimensional array of preferably discrete regions, each having a defined area, formed on the surface of a solid support such as, but not limited to, glass, plastic, or synthetic membrane. The density of the discrete regions on a microarray is determined by the total numbers of immobilized polynucleotides to be detected on the surface of a single solid phase support, preferably at least about 50/cm2, more preferably at least about 100/cm2, even more preferably at least about 500/cm2, but preferably below about 1,000/cm2. Preferably, the arrays contain less than about 500, about 1000, about 1500, about 2000, about 2500, or about 3000 immobilized polynucleotides in total. As used herein, a DNA microarray is an array of oligonucleotides or polynucleotides placed on a chip or other surfaces used to hybridize to amplified or cloned polynucleotides from a sample. Since the position of each particular group of primers in the array is known, the identities of a sample polynucleotides can be determined based on their binding to a particular position in the microarray.

[0032] Because the invention relies upon the identification of sequences that are over- or under-expressed, one embodiment of the invention involves determining expression by hybridization of mRNA, or an amplified or cloned version thereof, of a sample cell to a polynucleotide of a disclosed sequence. Preferred polynucleotides of this type contain at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, at least about 32, at least about 34, at least about 36, at least about 38, at least about 40, at least about 42, at least about 44, or at least about 46 consecutive bases of a sequence that is not found in other human sequences. The term “about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Longer polynucleotides may of course contain minor mismatches (e.g. via the presence of mutations) which do not affect hybridization to the nucleic acids of a sample. Such polynucleotides may be label to assist in their detection; alternatively, the nucleic acids to which such polynucleotides will hybridize may be labeled. Such polynucleotides may also be immobilized, such as by attachment to a solid support.

[0033] Even more preferred are polynucleotides of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, at least or about 400, at least or about 450, or at least or about 500 consecutive bases of a sequence that is not found in other sequences in the human genome. The term “about” as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value. The polynucleotides may of course contain minor mismatches which do not affect hybridization to the nucleic acids of a sample.

[0034] In another embodiment of the invention, all or part of a disclosed sequence may be amplified and detected by methods such as the polymerase chain reaction (PCR) and variations thereof, such as, but not limited to, quantitative PCR (QPCR), reverse transcription PCR (RT-PCR), and real-time PCR, optionally real-time RT-PCR. Such methods would utilize one or two primers that are complementary to portions of a disclosed sequence, where the primers are used to prime nucleic acid synthesis. The newly synthesized nucleic acids are optionally labeled and may be detected directly or by hybridization to a polynucleotide of the invention. The newly synthesized nucleic acids may be contacted with polynucleotides (containing sequences) of the invention under conditions which allow for their hybridization.

[0035] Alternatively, and in another embodiment of the invention, expression of a sequence may be determined by analysis of expressed protein encoded by said sequence in a cell sample of interest by use of one or more antibodies specific for one or more epitopes of the individual products (proteins) in said cell sample. Such antibodies are preferably labeled to permit their easy detection after binding to the gene product. In the case of a protein that may be found in the blood, serum or other bodily fluid, the assay may modified to use such materials in place of a breast cell containing sample.

[0036] The term “label” refers to a composition capable of producing a detectable signal indicative of the presence of the labeled molecule. Suitable labels include radioisotopes, nucleotide chromophores, enzymes, substrates, fluorescent molecules, chemiluminescent moieties, magnetic particles, bioluminescent moieties, and the like. As such, a label is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means.

[0037] The term “support” refers to conventional supports such as beads, particles, dipsticks, fibers, filters, membranes and silane or silicate supports such as glass slides.

[0038] As used herein, a “breast tissue sample” or “breast cell sample” refers to a sample of breast tissue or fluid isolated from an individual, preferably suspected of being afflicted with, or at risk of developing, breast cancer. Such samples are primary isolates (in contrast to cultured cells) and may be collected by a non-invasive means, including, but not limited to, ductal lavage, fine needle aspiration, needle biopsy, the devices and methods described in U.S. Pat. No. 6,328,709, or another suitable means recognized in the art. Alternatively, the “sample” may be collected by an invasive method, including, but not limited to, surgical biopsy.

[0039] “Expression” and “gene expression” include transcription and/or translation of nucleic acid material, such as the sequences of the invention.

[0040] As used herein, the term “comprising” and its cognates are used in their inclusive sense; that is, equivalent to the term “including” and its corresponding cognates.

[0041] Conditions that “allow” an event to occur or conditions that are “suitable” for an event to occur, such as hybridization, strand extension, and the like, or “suitable” conditions are conditions that do not prevent such events from occurring. Thus, these conditions permit, enhance, facilitate, and/or are conducive to the event. Such conditions, known in the art and described herein, depend upon, for example, the nature of the nucleotide sequence, temperature, and buffer conditions. These conditions also depend on what event is desired, such as hybridization, cleavage, strand extension or transcription.

[0042] Sequence “mutation,” as used herein, refers to any sequence alteration in the sequence of a gene disclosed herein interest in comparison to a reference sequence. A sequence mutation includes single nucleotide changes, or alterations of more than one nucleotide in a sequence, due to mechanisms such as substitution, deletion or insertion. Single nucleotide polymorphism (SNP) is also a sequence mutation as used herein. Because the present invention is based on the relative level of sequence expression, mutations in non-coding regions of genes as disclosed herein may also be assayed in the practice of the invention. “Detection” includes any means of detecting, including direct and indirect detection of gene expression and changes therein. For example, “detectably less” products may be observed directly or indirectly, and the term indicates any reduction (including the absence of detectable signal). Similarly, “detectably more” product means any increase, whether observed directly or indirectly.

[0043] Increases and decreases in expression of the disclosed sequences are defined in the following terms based upon percent or fold changes over expression in normal cells. Increases may be of 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 140, 160, 180, or 200% relative to expression levels in normal cells. Alternatively, fold increases may be of 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or 10 fold over expression levels in normal cells. Decreases may be of 10, 20, 30, 40, 50, 55, 60, 65, 70, 75, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 99 or 100% relative to expression levels in normal cells.

[0044] Unless defined otherwise all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this invention belongs.

[0045] Specific Embodiments

[0046] The present invention relates to the identification and use of three sets of sequences for the detection of non-normal and cancerous breast cells. The differential expression of these sequences in non-normal or abnormal breast cells relative to normal breast cells is used to identify a breast cancer cell as being non-normal or otherwise abnormal. The invention is advantageously used to identify breast cells as being those of ADH, DCIS, and IDC as otherwise determinable standard pathological techniques. The invention may also be applied to the identification of breast cells as being those of atypical lobular hyperplasia (ALH), lobular carcinoma in situ (LCIS), and invasive lobular carcinoma (ILC) as otherwise determinable by standard pathological techniques.

[0047] Other non-limiting examples of non-normal or abnormal cells include malignant cells, atypical cells (including reactive and pre-neoplastic), neoplastic cells, tumor cells, and cancer or cancerous cells.

[0048] The sequences(s) identified by the present invention are expressed in correlation with non-normal breast cells, and thus negatively correlated with normal breast cells. For example, CRIP1, identified by I.M.A.G.E. Consortium CloneID 1323448 and cluster NM—001311 (“The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and their Expression,” Lennon et al., 1996, Genomics 33:151-152; see also image.llnl.gov) has been found to be useful in discriminations between normal and ADH or DCIS or IDC breast cells.

[0049] In preferred embodiments of the invention, any sequence, or unique portion thereof, of the CRIP1 sequences identified by the cluster, as well as UniGene Homo sapiens cluster Hs.17409, maybe used. The consensus sequence of the I.M.A.G.E. Consortium cluster is as follows, with the assigned coding region (ending with a termination codon) underlined and preceded by the 5′ untranslated and/or non-coding region and followed by the 3′ untranslated and/or non-coding region: 1 (consensus sequence for CRIP1) GGCACGAGGGCCCGTGCCGCCCCAGCCGCTGCCGCCTGCACCGGACCCGGAGCCGCC SEQ ID NO:1 ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGGAAAAAAAAAAAAAAAAAAA

[0050] The sequences identified as belonging to the I.M.A.G.E. Consortium and UniGene clusters, with the assigned coding region underlined, follow below. The 5′ and 3′ untranslated and/or non-coding regions are by reference to the assigned coding region, which is presented as the complementary strand in the 3′ to 5′ direction for some of the sequences. 2 (CloneID 5103334) GGGGATTGGAGATGTTCCCCTCATGGAGGGTGCTGAGGACCTTAGGGTGGGCTGCCAGGCTG SEQ ID NO:2 GGCGGATGCGGGCTAAGTGCACAGGGCCTTGGGCAGAGCTGGCTGCAAGAGGCGGGTACGCC AGTGGTGGGTAGGCGCCCGCG TCCTGCAGCGTCTCACCGGGGCCTGTCTGTGCCTCTGCAGCCGAGAGGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGAGCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGGAAAAAAAAAAAA (CloneID 5777677) GCACGAGCGCTGGGCTAGGGGCGCGGCTTGAACTCGCCTAAAGAGCTGCGCCCTCTCATCTC SEQ ID NO:3 GCGCCTGCAGCCCGTGCCGCCCCAGCCGCTGCCGCCTGCACCGGACCCGGAGCCGCC ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCCAGAGGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTCGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTCCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGG (CloneID 563289) GCACGAGCGCTGGGCTACGGGCGCGGCTTGAACTCGCCTAAAGAGCTGCGCCCTCTCATCTC SEQ ID NO:4 GCGCCTGCACCCCGTGCCGCCCCAGCCGCTGCCCCCTGCACCGGACCCGGAGCCGCC ATCCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGCGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCCAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGACCACGAACGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTCTTGCCCCTAATGCTCTCAGTAAACCTGAACAC T (CloneID 1627147 in 3′ to 5′ orientation) TGGTTTTCCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGGAGCCCTGCGCATC SEQ ID NO:5 TGGGGACAAGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCTC CACCACCTGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTA CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGCCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGGCGAAGTACACCTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGGTGCAGGCGGCAGCGGCTGGGCCGGCACGGGCTGCAGGCGCGACAC TGGGTGGATCCGGCCTGGTCCGCGCCTTTCAGGGACCCCGGGACCCCGCCCCTTGGAGACAC CGCCCCTC (CloneID 1627139 in 3′ to 5′ orientation) TGGTTTTCCAAGTGTTCAGGTTTACTGAGACCATTAGGGGCAACAAGGGAGCCCTGGGCATC SEQ ID NO:6 TGGGGACAAGGCCTGCCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCTC CACCACCTGGT TTACTTGAAAGTGTGGCTCTCGGCTCCCCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTA CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGGCCAAGTACACCTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGCTGCAGGCGGCAGCGGCTGGGGCGGCACGGGCTGCAGGCGCGAGAC TGGGTGGATCCGGCCTGGTCCGCGCCTTTCA (CloneID 3296101 in 3′ to 5′ orientation) TTGGTTTTCCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGCAGCCCTGCGCAT SEQ ID NO:7 CTGGGGACAAGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCT CCACCACCTGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTG CGTAGCAGGGCTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGGCGAAGTACACCTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGGTGCAGCCGGCAGCGGCTGGGGCGGCACGCGCTGCATGCGCGAGAC TGGGTGGATCCGGCCTGGTCCGCGCCTTTCAGGGACCCCGGGACCCCG (CloneID 3631097) GCCGCCTGCACCGGACCGGAGCCGCC SEQ ID NO:8 ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGG CAAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGTG GGGCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTG GGCCTAAAGGCTTTGGGCGGGGCGGAGCCGAGGAGCCACACTTTCAAGTAA AACCAGGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCCACTTGTCCAGGGCAAAAT TGCCAGGCCTTTGTCCCCCACAATGCCCAGGGGCTCCCTTTGTTTGGCCCCCTTAATTGCTC TCAGTAAACCCTTGAACACTTGGA (CloneID 2782288) CAGCCCGTGCCGCCCCAGCCGCTGCCGCCTGCACCGGACCCGGAGCCGCC SEQ ID NO:9 ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCAAGAGGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCACCCATGTTTGGG CCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTCCAGGGCCACTGTCCAGGCAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGT (CloneID 3903337) CACCGGACCCGGACCCGGCC SEQ ID NO:10 ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAAGGCTTTCGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCCTTGTTGCCCCCTAAATGCTCTCCAGGTAAAACCT GAAACACTTGGAAAAAAAAAACAAAAAAAAAAA (CloneID 2063820 in 3′ to 5′ orientation) TCCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGGACCCCTGGGCATCTGGGGA SEQ ID NO:11 AAAGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAACGATGGGGTCTCCACCAC CTGG T TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATCGCTA CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCACAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGGCTGCAGAGGCACAGACAGGCCCCGGTGAGACGCTCCAGGA CGCCGCGCCTACCCACCACTGGCGTACCCGCCTCTTGCAGCCAGCTCTGCCCAAGGCCCTGT GCACTTAGCCCGCATC (CloneID 2568304 in 3′ to 5′ orientation) TTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCAAGGGTTCAGGTTTACTGAAAGCATTAGCGG SEQ ID NO:12 CAACAAGGGAGCCCTGGGCATTTGGGGACAAGGCCTGGCATTTCCCTGGACAGGGGCCCTGC AAGCAGCCAAGGATGGGGTCTCCACCACCTGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATCGCTG CGTAACAGGGGGGGGTTGCANTACGGTTTGCCTTCGGGCTCAGCGTGGCCCCCAAAGGTCAG CGTCTTCCCACATTTTTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAAAAACGTCA CCCTCTCGGCAAAGTACACCTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGGTGCAGGCGCCAACGGCTGGGGCGGCA (CloneID 2329226 in 3′ to 5′ orientation) CCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGGAGCCCTGGGCATCTGGGGAC SEQ ID NO:13 AAGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCACCCAAGGATGGGGTCTCCACCACC TGGT TTACTTGAAAGTGTGGCTCTCGGCTCCCCCCCGCCCAAAGCCTTTAGGCCCAAACATGCCTA CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCACCGTGGCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGACGTCAC CCTCTCGGCGAAGTACACCTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGGTGCAGGCGGCACCGGCTGGGGCCGCACGGGCTGCAGGCGCGAGA (CloneID 5433206) GGCCCCTGCCGCCCCAGCCGCTGCCGCCTGCACCGGACCCGGAGCCGCC SEQ ID NO:14 ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGACGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGGAAACAAACACACAAAAAAAAAAACAAAACAAAAAAAACACAAACCAAAAAACACGAGA AAAGCACAAAAAAAGAGGCAAAGAGAAAAACGCGCGCGGGATATCAGAGGCAGGAGGGGCGA AAAGGGGGGAGACAGAGGAGGAACAGCGACAACCGGCACCGCGCGC (CloneID 5220536) GCCGTGCCGCCCAGCCGCTGCCGCTGCACCGGACCCGGAGCCGC SEQ ID NO:15 ATGCCCAAGTGTCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGGC AAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGGG CCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGC CTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAA CCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCCAGATGCCCAGGGCTTCCCTTTGTTGCCCCTAATGGCTCTCAGTAAACCTTG AACAACTTGGAAACACCACACCAAAAACCAACACACAGGG (CloneID 2387987 in 3′ to 5′ orientation) CAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGGAGCCCTGGGCATCTGGGGACA SEQ ID NO:16 AGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCTCCACCACCT GGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTG CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTTAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGGCGAAGTACACCTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGGTGCAGGCGGCAGCGGCTGGGGCGGCACGGGCTGCAGGCGCGAGAT GAGAGGGCGCAGCTCTTTAGGCGAGTTCAAGCCGCGCCCCTAGCCCAGCG (CloneID 5186252) TGCAGCCGTCCGCCCAGCCTGGTGCGCTGCACGGACCCGGAGCCGCAT SEQ ID NO:17 GCGACGAGTGTCCAATGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGGC AAAGACTGGCATCTGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGG CCTAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATTGCCAG GGCCTTGTCCCCCAGATTGCCCAGGGCTCCCTCTTGTTGCCCCCTAAATTGCTCTCAGGTTA GAACCTTGAAACAGCTTTGCGAACAAGCAAAAGAAGAGAAGGAGGTGCTGATAATAGCAGAC GAAGTGAGAAGAGAACACCAATCACATGAACACGAATAGGCAGGCCATACAACGCAGGAGAT ATCGAACCCGGCGATAGTGCCCGGT (CloneID 3609948) CGGACCCGGAGCCGCC SEQ ID NO:18 ATGCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGG CAAGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGG GCCACGCTGAGCCAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCC TAAGCCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGGA (CloneID 1584777 in 3′ to 5′ orientation) CCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGGAGCCCTGGGCATCTGGGGAC SEQ ID NO:19 AAGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCTCCACCACC TGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCGCCCAAAGCCTTTAGGCCAAACATGGCTGCG TAAGAGAGTGGTTGAAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTGAGCGTC TTCCCACATTTCTCGCAGTTCAGGCAGGGCAGAGTGCAGTCCTTGCCCAGAGAGGGGACCTC TCGGCGAAGAGAACTCCTTGTTGCACTTGGGACACTTGGGCAT GGCGGCTCCGGGTCCGGTGCAGGCGGC (CloneID 2130246 in 3′ to 5′ orientation) AGCGGCCGCCCTTTTTTTTTTTTTTTTTTCCAAGTGTTCAGGTTTACTGAGAGCATTAGGGG SEQ ID NO:20 CAACAAGGCAGCCCTGGGCATCTGGGGACAAGGCCTGGCATTTGCCTGGACAGTGGCCCTGC AAGCAGCCAAGGATGGGGTCTCCACCACCTGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTG CGTAGCAGGGGTCGTTGCAGTACGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGCCGAAGTACACCTCCTTGTTGCACTTGGGACAC (CloneID 1908782 in 3′ to 5′ orientation) CCAAGTGTTCAGGTTTACTGAGACCATTAGGGGCAACAAGGGAGCCCTGGGCATCTGGGGAC SEQ ID NO:21 AAGGCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCTCCACCACC TGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTG CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTCCTCAGCGTGGCCCCCACAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGGGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC TTCTCTCGGCGAAGTCCACCCTCCTTGTTGCACCTTGGGACACCTT (CloneID 1323448 in 3′ to 5′ orientation) GAGCATTAGGGGCAACAAGGGAGCCCTGGGCATCTGGGGACAAGGCCTGGCATTTGCCTGGA SEQ ID NO:22 CAGTGGCCCTGCAAGCAGCCAAGGATGGGGTCTCCACCACCTGGT TTACTTGAAAGTGTGGCTCTCGGCTCCGCCCCCCCAAAGCCTTTAGCCCAAAACATGGCTGC GTACGAGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGCGT CTTCCCACATTTCTCGCACTTCAGCCAGGGCGANTGCCAGTCCTTGCCCAGAGAGGTCACCC TCTCGGCGAAGTACACCTCCTTGTTGC (CloneID 1837171 in 3′ to 5′ orientation) TTTGGTTTTCCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGCACCCCTGGGCA SEQ ID NO:23 TCTGGGGACAAGCCCTGGCATTTGCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGGGTC TCCACCACCTGGT TTACTTCAAACTGTGGCTCTCGGCTCCGCCCCGCCCAAAGCCTTTAGGCCCAAACATGGCTG CGTAGCAGGGGTGGTTGCAGTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGC GTCTTCCCACATTTCTCGCACTTCAGGCAGCGCCGATGCCAGTCCTTGCCCAGAGAGGTCAC CCTCTCGGCGAAGTACACCTCCTTGTTGCACTTGGGACACTTGGG (CloneID 2802267) GCGTCGACCCCCGAGAGGGTCACCTCTCTGGGCAAGGACTGGCATCGGCCCTGCCTGAAGTG SEQ ID NO:24 CGAGAAATGTGGGAAGACGCTGACCTCTGGGGGCCACGCTGAGCACGAAGGCAAACCCTACT GCAACCACCCCTGCTACGCAGCCATGTTTCGGCCTAAAGGCTTTGGGCGGGGCCGAGCCGAG AGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCGCTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCT (CloneID 2847309) AAGGTAGCGAAGCGAGAGGGTGACCTCTCTGGGCAAGGACTGGCATCGGCCCTGCCTGAAGT SEQ ID NO:25 GCGAGAAATGTGGGAAGACGCTGACCTCTGGGGGCCACGCTGACCACGAAGGCAAACCCTAC TGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGGCTTTGGGCGGGGCGGAGCCGA GAGCCACACTTTCAAGTAA ACCAGGTGGTGGACACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATCCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGGAAAACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAATTTCN (CloneID 5018693) GCCCAAGTGTCCCAAGTGCAACAAGGAGGTGTACTTCGCCGAGAGGGTGACCTCTCTGGGCA SEQ ID NO:26 AGGACTGGCATCGGCCCTGCCTGAAGTGCGAGAAATGTGGGAAGACGCTGACCTCTGGGGGC CACGCTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCC TAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAA ACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAAATGCCAGG CCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC TTGGAAAAGCAAAAAAAAAAAAAAAAAA (CloneID 155219 in 3′ to 5′ orientation wherein the coding and 3′ untranslated and/or non-coding regions are present or similar to that in CloneID 563289) GCATTAGGGGCAACAAGGGAGCCCTGGGCATCTGGGGACAAGGCCTGGCATTTGCCNGGACA SEQ ID NO:27 GNGGCCCTGCAAGCAGCCAAGGATGGGGNCTCCACCACCTGGN TNACTTGAAAGTGTGGCTCTCGGCTCCGCCCGCCCAAAGCCTTNAGGNCCAAACATGGCTGC GNANAGGNGNTGGTTGCAGNAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGGTCAGCG TCTTCCCACATTTCTCGCACTTCAGGCAGGGCCANTGCCANTCCTTNCCCAGAGAGGTCACC CTCTCGGCGAAGTACACC (CloneID 307716 in 3′ to 5′ orientation wherein the coding and 3′ untranslated and/or non-coding regions are present or similar to that in CloneID 563289) 307716 (3′) TTTTTTTTTTTTTTCCAAGTGTTCAGGTTTACTGAGAGCATTAGGGGCAACAAGGGAGCCCT SEQ ID NO:28 GGNATCTGGGGACAAGGCCTGGCATTTCCTGGACAGTGGCCCTGCAAGCAGCCAAGGATGGG GTCTCCACCACCTGGT TTACTTGAAAGTGTGGCTCTCGCCTCCGCCCGCCCAAAGCCTTTAGNCNCAAACATGGATAT GGCTACGTAGCAGGGGTGGTTGCANTAGGGTTTGCCTTCGTGCTCAGCGTGGCCCCCAGAGG TCAGCGTCTTCCCACATTTCTCGCACTTCAGGCAGGGCNAATGCCANTCCTTGCCCAGAGAG GTCACCCTCTCGGG

[0051] In another set of preferred embodiments of the invention, any sequence, or unique portion thereof, of the HN1 sequences identified by the I.M.A.G.E. Consortium CloneID 471568 and cluster NM—016185, as well as UniGene Homo sapiens cluster Hs.109706, may be used. HN1 sequences are useful in discriminations between normal and DCIS or IDC (of grades I to III) breast cells. Its expression is also increased in grade III relative to grade I breast cancer cells.

[0052] The consensus sequence of the I.M.A.G.E. Consortium cluster is as follows, with the assigned coding region (ending with a termination codon) underlined and preceded by the 5′ untranslated and/or non-coding region and followed by the 3′ untranslated and/or non-coding region: 3 (consensus sequence for HN1) TGCAGCGGTGGTCGGCTGTTGGCTCTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGA SEQ ID NO:29 GCGTTCTCCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTCCCAGGCAGCCTGCGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCCTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCCTTCTGTCTGTTTCCTCCATGCTTGAGAACTGCACAACT TGAGCCTGACTGTACATCTTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTAAAAAA AAAAAAAAAAAA

[0053] The sequences identified as belonging to the I.M.A.G.E. Consortium and UniGene clusters, with the assigned coding region underlined, follow below. The 5′ and 3′ untranslated and/or non-coding regions are by reference to the assigned coding region, which is presented as the complementary strand in the 3′ to 5′ direction for some of the sequences. 4 (Clone ID 4795778) AGCGGGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTCTGGAGTTTCCCAGCGCCCCTCGG SEQ ID NO:30 GTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCGAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGGCCCCAACCCACAGGGAGTCTCTCCGCAGAGCCTTCTTGGTG TTGCCCTAACTTGCCAGTGGCCTTTGCTCAG AGCCTCCTCCTGTGACATGTGAACAATGAAGAGGCCTGCGCCTCCTGCCTTGCCGCCTGCAA AGCAAAGAAACTGCCTTTTATTTTTTAACCTTAACAAGTAGCCAGATAGTAACAAGACTGGC TGGCTGATGAGCAAAGCCTTTGCTCTCACGCAGAGGACGGCTTGGATGTACAATGAAACTGG CTGGAACTAAAGCAGTGAAGCAGGGGAGGCCATCACACTGAAGCGGGTCTTCCTCCAGGAAC GGGTCCACAAGGGTGTGTCTGAATTACCTGATGCTGTGTGCTGATGCTGGCTCTTGACCATG GACGGCAAGTTCATCTTAACCGTGCTGTCCTCACACCTGACTGTGCTCCCTTAACATTTCCC (Clone ID 5239921) CTCCTGCAGCCGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCT SEQ ID NO:31 TTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGCCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTGTTATCCCTTTGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGC CATGGCATGAGTGTTCCTAGTAGTAGATTGGAGGGAAAAGTTTGTGACCCTTAGTACGGGGT TTTAAGACGAAATAATTGGGTTCCA (CloneID 4623018) GGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCA SEQ ID NO:32 GCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTATTTTTTGCTTTGTGAAGACCAGGTTTCTCTCTGTCCTTGACCTCTGTGGGTCTGTG GGCCATGGCATGAGTGTTTCCTAGTAGTAGATGGGAGGGAAAGCTTGTGACCCCTTAGTACT GTGTTTTTACAC (CloneID 5729213) CGGTCCGGAATTCTCCGGATGCTGTTGGGTGTGGAGTTTCTACCGCCCCTCGGGTCCGACCC SEQ ID NO:33 TTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGC CATGGCATGAGTGTTTTCTAGTAGTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGTG TTTTTAAGAAGAAATAATTTGGTTCCAGATGTGTTANAAGATCTTTTGTACTGGAGTTTTTT ACACTTTTACTTGGGTTTAACCAGCCTCAACTGGGACGACCATAAACAGTCCACCAGGCACC GTTTCCTGCCAGGCCCCAAACCCACGGGAAGTCTCTCGCAAAAACCCCTTCCTGGGGGTTGC CCCTAATTTGCCAAGGGGCCTTTTGCTCCGGAGCCTCCCTCCCGGGGAATTGGGGAAACAAT GAAAAAGGCCTGTGCCCTCCGTGCCTTG (CloneID 5192505) CTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTG SEQ ID NO:34 AGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAACAGAAGCACTTTATGTACTGCT GTCTTATATCCTTTTGAAGAACAGGGTTTCTCTCTTGTCCTTGACCTCTGGGGTCTGTGGGC CCATGGCATGAAGTGGTTTCTAGTAGTTAGATGGCGCGCAAAGCTTTTGTGGACCCTATGTA ACTGGTGGTTTTTACGACAGACACTACTTTGGCTACCAGATGTGTTAGAGGAACCTTGGCAC TGGAGGTTTAACCACTTTACTGGGTTTACCAGGCCTTAGTGGCACGGCCCATAACGTCCACA GCCCCGATCCTGCCAGCCCAA (CloneID 3945044) TTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCC SEQ ID NO:35 AGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGCAAGAACAAAATGGCCTCTAATATCTTGGGACACCTGAACAAAATCAAGCTTCTTGCGCC AAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGAG AAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTC ATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCT GCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGG CGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTGTGGATTGTTCTCATTAAAAAGAAGCACTTTATGTACTGCT GTCTTTTTTTTTCCTTTTTGAAGAACCAGGTTTCTCTCTGTCTTGACTCTGGGGTCTGTGGG GCCATGGCATGAGTGTTTCTAGTAGTACATTGGCGGGAAACGCTTTGGGACCCTTTACTACC TGTGTTTCCACGGAACAAATTACTTTGGGGTCCCCATGTTGTTAA (Clone ID 5240530) CTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTGTG SEQ ID NO:36 GGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGCAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTNGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTAATTTTACTTTTGAAGAACAGCTTCTCTCTGTCCTTGACTCTGGGTCTGGGGCCAT GG (CloneID 3617626) TGGCTAGGTACGAGGCTGGGTTTGGGCGGACAGGCGGCAGCGGCGGCTCCTGCAGCGGTGGT SEQ ID NO:37 CGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCC GGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTCCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAGTCCAGCCTCGTCTTGGGTATAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAATGCACAACTT GAGCCTGACTGTCATCTCTGGGATTTGTTCATTAACAGAGCCTTATGTAAAAAAAAAAAAAA AACGCGGATTCTTCGGGGGGGAACAAGAAGAGGCCAGGGATA (CloneID 4814114) AGCGGGGGGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCT SEQ ID NO:38 CGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCTCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCACCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTCTTTCGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGCCAT GGCATTAGT (CloneID 4894047) TGATGGCAGTAATCTCGGGGTATAAGGTAGCGAGGCTGGGTGGCGCCTGCAGCGGTGGTCGG SEQ ID NO:39 CTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGC GCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGNGCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTTGTGAACTGGACAAG TTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCT GTCTATTCAGACCTTTTGAAAGACCAGGTTTCTCTCTGTCCTTGACTCTGGGGCCTGTGGGC CATGGACTGAGTGTTTCCTAGATAGCAGAT (CloneID 5531619) AATTTTCCGAAATCGTCGACCCACGCGTCCGTTTCCAGCGGTGGTCGGCTGTTGGGTGTGGA SEQ ID NO:40 GTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCG CTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTAAAAAAAAAAA AAA (CloneID 5588318) CGGTCCGGAATTCTCCGGATGCTGTTGGGTGTGGAGTTTCCCTGCGCCCCTCGGGTCCGACC SEQ ID NO:41 CTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTCTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGNGTCTGTGGG CCATGGCATGAGTGTTTTCTAGTAGTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGT GTTTTTAAGAGGAAATAATTTGGTTCCAGATGTGTTAGAGGATCTTTTGTACTGAAGGTTTT ACACCTTTACTTTGGGTTTACCAGCCTCCACTGGAACAGACATAAACAGTCCACAGGCAACC GTTCTGCCCAGCCCCAACCCCAGGGAAGTCTCTCCGCAAAACCTTTCTTGGGGTTGCCCTAA ACTTGCCAGGGGCCTTTGCTTCAAACCTCCCTCCTGTGAAATGTGTAACAAATGAAAAAGCC GTGGGCCTCTCTGCCTTTGCCCCCTTGAAAACAAAAAACCGGGCCTTTTTATTTTTTAACCT TAAAAAGAACCCCGATATTAAAAAAAATGGGTTGGGTGTTGAACAAAACCCTGTCCTTCCC (CloneID 5768283) TGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGA SEQ ID NO:42 GCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATGCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCT GTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTG GGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGC AGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGAT ATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGT GCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCC CTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGG CCATGGGCATGAGTGTTTTCTAGAAGTAGATTGGAGGGGAAAGCTTTGTGCGCACTTAAAAC CGGGGTTTTTAAAAAAAATTAACTTGGGTTCCCGAATGGGTTAGAAGAATCTTTTGGACCTG AGGTTTTTTAAACCTTTTAATTGGGGCTTAACCAAGCCTCTACTGGACCGAAATCATTAACA GGCCCCCCGGCTCCGCGTTCCTTGCCAGGGCCCCAACCCACAGGGGGAGTTCTCCTCGGCCC AAGCCCTTTTTTGGGGGCTCGCCCCCAAAATGTGCAGGGGGGCCTTTGCGCTCAAAACCTCC C (CloneID 5396994) GTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCCCCAGCCTA SEQ ID NO:43 CCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT GAGGAACAACAAAATGCCCTCTAATATCCTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAACCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTCAACGCTGTCGTTCTGGTCTGTTTCCTCCATGCTTTGTGAACTGGCACA ACTTGAGCCTGACTGGTACATCTCTTTGGATTTGTTTCCATTAAAAAGAAGCACTTTATGTA CTGCTCTCTTTATTAGCCCTTTGGAAGAACCGGTTTCTCTCTGTCCTGTGACTCCTGGGGTC TGTGGGCCATGGCATGAGGGTCTCTAGTAGTAGATTGAGGGAAAGCTTGTGGCCACTTAATA CTGGGTTTAAAGACGAAATACTTGTGGTCCAGATGTGTTACAAGGAACCTTGGCACGGAGGT TATAACACCTTTATGGGGTGTCCCAGGCTCCCTGGACGACCCTAAGCGTCCACGGCGCCGGT CCGCCGGCCCAC (CloneID 3941190) TTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCGACCCTTTGAGCGTTCTGCTCCGGCGCCA SEQ ID NO:44 GCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTA CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCCGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAAGAAGCACTTTATGTACTGCT GTCTTTTTTTTCCTTTCGAAGAACAGGTTGCTCTCTGCCTTGACTCTGTGGGTCTGTGGCGC ATGGATGAGTGTTCCTAGCTAGTAGATGGAGGGCAACTTTGGGGACCCTTAGCGTGGTTTAC CAGAAATACCTGGGTCCAGTGGCCCAGGCCTTGGCCGGGGTTCCACCTTCTGGGTTTCAGCT CACGGGAACCATAAACCAAGGCGCCGAGGCCACAGGATCCCGCCTTGTGGCATCCGGGGTGA CCCGTATGAAAAAGCGCCTCCAAATTTTTAAACACAAGCGCCCGGAGACCAT (CloneID 5928395) GCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:45 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGG CCATGGCATGAGTGTTTTCTAGTAATAGATTGGAGGGAAACCTTTGTGACACTTAATACTGT GTTTTTAAGAAGAAATAATTTGGTTCCAAATGTGTTAGGAGGATCTTTTTGTACTGAAGTTT TTAAAACTTTACTTGGGTTTTACCAAGCCCTCACCTGGGACAGACCCTTAACCGGTCCAACG GGCCACCGTTTCTTGCCAGGGCCCCAAACCCACAGGGGAAGTCTTCTCGCAAAAACCCTTCC TGGGGGGTTCCCCCTAACTTGCCCAGGGGCCCCTTTGCTCCAAAAC (CloneID 4750262) CGATCGGCCGGACAGGCGGCAGCGGCGGCTCCTGCAGCGGTGGTCGGCTCTTGGGTGTGGAG SEQ ID NO:46 TTTCCCACCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGC TCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGCAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTCGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGCCAAGTCCAGCCTCGTCTTGGCTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTGGTGTCATTACACAAGAAGCACTTTATGTACTGCT GGTCTATAAATATCCTTTGCGACGAACAGGTTCCTCTCTGCCTTGACTCTGGGGCCTGTGGG CCACTGGCAGTGAGTTGTGACTAGCTAGTAGATTGGGCGGAAACGCTTGGTGACCCTTAGCC CCTGGTTTCTACGACGCCATACTTGGTCCCGATGTGTTACAGGCCTCTTGCGCCGGAGGCTT TACACCCTTTACTGCGCTCCCAAGGCTCAGGGGCGACCTAA (CloneID 5274910) AGCGGAGCGGCGGCTCCTCCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCT SEQ ID NO:47 CGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCAAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTCACAAAGAAGCACTTTATGTAACTGC TGTCTTTTTTACCTTTTGAAGAACCGGTTCCTCTCTGTCCTTGACTCTGGGGTCTGGGGGCC AGGCATT (CloneID 3140086) TTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCCCC SEQ ID NO:48 GGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCAAATTTTTCATTAGGTTTTGATGAACCAACAGAACAAGGCG GTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTG GGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGC AGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGAT ATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGT GCCTTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCC CCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGGTTTCCTCCATGCTTGTGAACTGGACAAC TTGAGCCTGACTGTACATCTCTTGGATTGTGTTTCATTCAAAAGACGCACTTTATGTAACAC AAA (CloneID 5286160) AGCGGAGGGGCGGCTCCTGCAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCGAGCGCCCCTC SEQ ID NO:49 GGGTCCGACCCTTTGAGCGTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCG ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTACAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTCCTTTTGAAGAAC (CloneID 5215141) GGTACCGGTCCCGAGTTCTTTGGATGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAG SEQ ID NO:50 CGCCCCTCGGGTCCGACCCTTTGGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGG CGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAACGGTGAT ATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGT GCCTGCTGCGCCTGTGCCCACACCCGGTGGACCCGGACCCAGTTGCCATCCAGAAGAAATCC CCCTGGCGGCAAGTCCAGCCTCGTCTAGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACTT GAGCCTGACTGTTACATCTCTTGGATAAGTTTCATTAAAAAGAAGCACTTTATGTACTG (Clone ID 4845679) GAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCG SEQ ID NO:51 TTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTCTATGTACTGCTG TCTTTTTTTTTCTTTGGAAGAA (CloneID 5297866) AGCGGAGCGTCGGCTCCTCCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCT SEQ ID NO:52 CGGGTCCGACCCTTTGACCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAACCAAGCTCCGGAGACTTCTTAGATCTGAAGGGCGACGGTGATA TTCATGAACAATGTGGACACCAGACTTCCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCG TGCCTGCTGCGCCTTGTGCCCAGACCCGGTTGGCCCCGGCCCCCACTCCCATCCAGAAGAAA TCCCCCTCGCGGCATGTCAGCCTCGTCTTGGGTAA GCTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTACCTCCATGCTTGTTGAACTTGACA ACTTCGAGCCTGACGTGTACATCTCTTGGATTGGTTTCATTAAAAAAGAAGCACTTTATGTA CTGGCTGTCTTAAATAACTTTTGAAAGAAC (CloneID 5194208) CCAATCCCTGGATCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGG SEQ ID NO:53 GTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAATAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTCATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAACTCTAGTGGTGGCAGGGAAGACTTGCAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGACAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAACAGAAGCCCGTG CCTGCTGCGCCTCTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTGTGTGAAACTGGACAA CTTGAGCCTGACTGTACATCTCGTTGGATTGGTTTCATTAACAAAGAAGCACTTTATGTACT TGCTGTCTTTTGATGCTTTGGAGAGAACAGGTTACTACTCTGGCCCTTGACTCTGGGGTCTG TGGGCCATGGCATGAGTGTTTACTACGTAGCACAACTGGCCCGGAAACGCTCCGGTGAGACC CATTAGCTACGGGGGTTTTAAGAACGCAAATTAATCGCGTACGCGAATGTGGTACAAGGACA CTGTAGGACACGGACGCTGTAACACACTTAACAAGCGGTTTCACCAGGACCTCAACGGAGAC CGACCATATAACGGCCACAGGAGCACGGACATGACAGGGCCAAGCC (CloneID 5017113) GCCTGCAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:54 GAGCGTTCTCCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGCAGACTTCTTAGATCTGAAGGCAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCACCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGCCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGCCAAGTCCAGCCTCGTCTGTGGCTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGACAATTG AGCCTGACTGTACATCTCTTGGATTGGGTTTCATTAAAAAGAAGCACTTTAAAAAAAAAAAA GAAAAAAAAAAAAAT (CloneID 5483414) TTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCC SEQ ID NO:55 AGCCTACCTCGCTCCTCCGCCCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCCAGTTTT GCGGCCTCCAGGTGGTCCATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGCCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTCAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAACAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTCCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGG CCATGGCATGAGTGTTTTCTAGTAGTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGT GTTTTTAGAAGAAATAATTTGGTTCCAAATGTGTTAAAGGATCTTTTGAACTGAGGTTTTTA AACACTTTACTTGGGTTTCCCAAGCCTCAACTCGACAGAACATAAACAGTCCACAGGCACCG GTTCCTGCCAGGGCCCAAACCCACAGGAAATCCTTTCGCCAAAAACCCCTTCTTGGGGGTGG CCCCTACTTGGCCAGTGGCCCTTTGCTCCAAAACCTCCTCCTGGGAACCGGGGGAAAACATT GAAAAGGCCCTGGGGCCTCCCT (CloneID 5778829) GCACGAGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCG SEQ ID NO:56 TTCTGCTCCGGCGCCAGCCTACCTCCCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT CCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGACACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCACGCAGCCTGGGGCAGAGTGAACAGAAGCCCGTC CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAACAAATCCCCC TGGCGGCAAGTCCAGCCTCG (CloneID 5778829 in 3′ to 5′ orientation) TTTTTTTTTTTTTTTTTTTTTTTACATAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGA SEQ ID NO:57 TGTACAGTCAGGCTCAAGTTGTGCACTTCACAAGCATGGAGGAAACAGACAGAACGACAGCG TTCAGGACACTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGGT CGACTCCCTTGAAGGT (CloneID 2781859) GAGCGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGC SEQ ID NO:58 TCCCACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCCACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATCAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCGCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCCTCTTG (CloneID 2781859 in 3′ to 5′ orientation) TTTTTTTACATAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGCCTCA SEQ ID NO:59 AGTTGTGCACTTCACAAGCATGGAGCAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGAGGCCCCANAACTCGGGAGCTATTCCTGCTGTTGGGGT CGACTCCCTTGAAGGTCGTGGTTGTGGTCAT (CloneID 3940455) GGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGC SEQ ID NO:60 CTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTC CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGCCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGACACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGACTGAAGAGAAGCCCGTGC CTGCTTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAAGTCCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTNTCCTCCATGCTTGGTCGAACTCACAAT TTGAGCCTGGACTGTACATCTCTGGGAATTGGTTTCATTAAAAAGAAGCACTTTAAAAAAAA AAAAAAAAAAAAAAAAAAAGAAAAAAAAAAAAACCGGAGAGATAAAAAGGGGGGGGAGAAAA GTGGAAAAAAAGACCAGCCGCAAACATTTGCCGGACCCTTTTTGGCGACACAGGGGAAAACG GGAGCCCCAAAGGAGGTAAATGAAACGGTTCTTTTTTTCTTATTTCAGAAAGCAGAAGAAAA AGAAATAAAGAAAAGAAAGAAAAAAAAAGAATGATAAAAGAGGAAAAATAAAAAAAAAGAAA AAGAGAGAGAATAGAAACTTAAAAAATAAACAGAAAAAAGAA (CloneID 5459503) GCTGCAGCGGTGGTCCGCTGTTGGCTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:61 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGCACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAACAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGT GCCTCCTGCGCCTGTCCCCAGCCCGGTGGCCCGGCCCCAGTCCCATCCAGAACAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTCCCCTTCCCAAACGAAGCACTTTATGTACTGC TGTCTTTTTTTTTTCCCTTTGGAACGCCCCCCGGTTCCTCTCTGTCCCTTCACTCCTGGGGT CTGGGGGCCTG (CloneID 4539292) TGCAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:62 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGCGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGCTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGCCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTGTTTCATTAAAAAGAAGCACTTTATGTAAAAAAAA AAAAAA (CloneID 5247820) CTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCAGCGCCCCTCGGGTCGACCCTTT SEQ ID NO:63 CAGCGTTCTGCTCCGGCGCCACCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGACTTTT CCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTCGAGTCATCTGGACTGCA GAGAAGG AACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTCATGA AAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAACGAGAAGCCCGTGCCTGCT GCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGCCGG CAAGTCCAGCCTCGTCTGGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTCGATTTGTTTCATTACAAAGAAGCACTTTATGTACTGCTG TCTTTATATTTTGTCCTTTGTGAGAACAGGTCCTCTCGTGTCCTTGACTCTGGGGTCTGTGG C (CloneID 5397495) CTCCTGCAGCGCTGGTCGGCTGTTCCGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCT SEQ ID NO:64 TTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTACGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGCACACCTGAACGAAAATCAAGCTTCTTG GGCCAACTCACCAGGTGCCAACCTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTG CAGACAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGCACCAAGGT GATACTTCATGAAAACTGTGGACACAGACTTGCCAGGCACCCTGGGGCAGACTGAACAGAAG CCCGTGCCTGCTCCCCCTGTGCCCAGCCCGGTGGGCCCTCGCCCAGTGCCATCCACGAACGA AATCCCCCTGGCTCGCAATGTCCACCCTCGTCTTGGGTTACG CTCTGACTGTCCTGAACGCTGTCCTACTGTCTGTCTCCTCCATGCTCGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGCATTCGTATCATTAACCAAGAACCACTTTATGTACTCCT GTCTTTATTTACGCCTTTCGAAGACCG (CloneID 5200412) CTCCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTG SEQ ID NO:65 AGCGTTCTGCTCCGGCCCCAGCCTACCTCGCTCCTCGGCCCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACACCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTCCCAAGTCTAGTCGTGGCAGGGAACACTTGGAGTCATCTGCACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTCAAGGGACAACGTGATA TTCATGAAAATGTGGACACAGACTTCCCAGGCAGCCTGGGGCACAGTGAAGACAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTGTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGGTACATCTCTTGGATCCGTTTCATTAAAAAGAAGCACTTTATGTACTGCT GTCTTTATTTTCACTTTAGACCAACCAGGTGTCTCTCGTGTCCTGGACTCCTGGGACCTGTG GGCCATG (CloneID 5208934) CTGCAGCGCTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTC SEQ ID NO:66 ACCGTTCTCCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATCAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTC TCTTTTTTTTCCTTTTGAAGACCAGGTTCTCTCTGTCCTTGACTCTTGGGCTCTGTGGGCCC C (CloneID 4156130) CCCACCCCTGGCCCCCTCTTGGGTGTGGAGTTTCCCACCCCCCCTCGGGTCCGACCCTTTGA SEQ ID NO:67 GCCTTCTCCTCCCGCGCCAGCCTACCTCCCTCCTCCCCCCC ATGACCACAACCACCACCTTCAACCCAGTCCACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCCCCCTCCAGGTGGTGGATCCAATTTTTCATTACGTTTGATGAACCAACACAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTACTCGTGGCAGGGAAGACTTCGACTCATCTGGACTGCAG ACAAGGAACTCCTCTCAACCAACCTCCCGAGACTTCTTAGATCTGAACGGAGAAGGTGATAT TTATGAAAATGTGCACACAGACTTCCCAGGCAGCCTGGGGCACAGTCAAGAGAAGCCCGTGC CTGCTGCGCCTCTCCCCACCCCCGTCGCCCCGGCCCCACTGCCATCCAGAAGAAATCCCCCT GGCGGCAACTCCACCCTCCTCTTGGGTTAG CTCTGACTCTCCTCAACCCTCTCGTTCTGTCTGTTTCCTCCATCCTTGTGAACTGCACAACT TGAGCCTCACTGTACATCTCTCTGGATTGTTTCATTAAAAAGAAGCCCTTTATGTACTCCTG TCTTTATCTTTCCTTTCCAGGACCCGGTTTCCCCCCCCTCCTGGCCTCTGCCTCCTCGGCCC CTGCCTTCGCTCTTC (CloneID 4123030) GCTCCTGCAGCGGTGGTCGGCTGTGGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCC SEQ ID NO:68 TTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGCGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTC CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGCC AAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGAG AAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAAGGTGATATTC ATGAAAATGTGGACACAGACTTGCCAGGCAGCTGGGGCAGAGTGAAGAGAAGCCCGTCCCTG CTGCGCCTGTGCCCAGCCCGGTGGCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGGGCG GCAAGTCCAGCCTCGTCGTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGACAACTT CAGCCTGACTGTACATCTCTGGGATTGTTCATTAAAAGAAGCACTTTATGTACTGCTGTCTT TTTTTTCTTTTGAGGACGGTTCTCCCTGTCCTGACTCTGGTTGGGGGGCAGGGTGAGGGTTC TAAAAAGGGGG (CloneID 5459215) GGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCGACCCTTTGAG SEQ ID NO:69 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGACAGGAATAGCTCCCGAGTTT TGCGGCCTCCAGGTGCTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCT GTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTG GGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGC AGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAAGGTGAT ATTCATGAAAATGTGGACACACACTTGCCAGGCAGCCTGGCGCAGAGTGAAGAGAAGCCCGT GCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCGGCCCAGTGCCATCCACAAGAAATCCCCCT CGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTTCCTCCATGCTTGTGAACTGCACAAT TGAGACCTCACTGCTACATCTCTGCATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCT GTCTTTATTTTTCCTTGTGAACA (CloneID 4337230) GCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTT SEQ ID NO:70 TGAGCGTTCTGCTCCGCCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGC GCCAAGTCAGCAGGTCCCAACTCTAGTGGTGCCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGCGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCCTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGACAATTG AGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTAAAAAAAAAAAAA AGAGAAAAGAAAAACCGGGGGTTTTTTGGGGGGGGAAAAGAGGGTTAAAGGCGGGGTAGGTT TTTGCCCTTTTTGAAAGGGGAGACGGGGGCCCAGGGGGGGTAATGGAAGGGGACG (CloneID 4649355) GCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:71 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGCTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCACAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGACCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TCAGCCTGACTGTACATCTCTTGCATCTGTTTCATTAAACAGAAGCACTTTATGTACTGCTG TCTCACTACAAATACACTATCGAACAACAGGTTACTACTCTGTCCTTGAN (CloneID 4126162) CCTGCAGCGGTGGTCGGCTGTTGCGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:72 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGCGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTCAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGCGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTCCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTTCTCTCTGTTTCCTCCATGCTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTGGGATTGTTCATTCAAAAGAAGCACTTTATGTACTGCTGTC TTTTTTCCCTTGGACACCAGGTTCCCCTCCCTCCTTGACTCCTGGCTTTGGGGCCCGGCCAG AGTGTTCCTATAACAATGGGCGGAAAACCTTGGGCACCTAGCCCGGTTAAAGAAAAATGGGC CACTGGTAAGC (CloneID 2783676 in 3′ to 5′ orientation) TTTTTTTACATAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCA SEQ ID NO:73 AGTTGTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCTTCAGATCTAAGAAGTCTCCGGAGCTTGCTTCAGAG GAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGCCACCACTAGACTTGGCACC TGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCAAAGATATTAGAGGCCATTT TGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAATGAAAAATTGGATCCACCA CCTGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGGTCGACTCCCTTGAAGGTGGT GGT (CloneID 2783676) GCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:74 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGAAAATGTGGACAC AGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCA GCCCGGTGGCCCCGGCCCCAGTGCC (CloneID 2822776 in 3′ to 5′ orientation) TTTTTTTTTTACATAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGC SEQ ID NO:75 TCAAGTTGTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCA GAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGAGGCCGCAAAACTCGGGIAAGCATTCCTGCTGTTGG (CloneID 2822776) GGCACGAGGGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGCTCCGACCCTTTGAGCGT SEQ ID NO:76 TCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGACTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAACAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAAAAATCCCCC TGGCGGCAAGTCCAGC (CloneID 2781579) GCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:77 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAATGAAAAAAACCCGTGC CTGCTGCCCTGTGCCCAGCCCGTGGCCCCCGGCCCATGCCATCAAAAAAATCCCCCTGCCGC GAACCAACCTTTGCTG (CloneID 2781579 in 3′ to 5′ orientation) TTTTTTTACATAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCA SEQ ID NO:78 AGTTGTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGGT CGACTCCCTTGAAAGTGGTGGT (CloneID 5419867) GCAGCGGTGGTCGGCTGTTGGGTGTGCAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:79 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTCGATCCAATTTTTCATTAGGTTTTGATGAACCAACACAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAACTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGTTTTCATAGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAG AAGCCCGTGCCTTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGACCCAGTGCCATCCAGAA GAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT AGAGCCTGACTGTACATCTCTATGGATATGTTTCATTAAAACAGAAGCACTTTATGTACTGG TGTCTTTATTATTTCTTTGGAAGACCAGGTTCTCCTCTGGCCTAGAATCCTGGGGGTCTGAG G (CloneID 4328715) CGCTGATTGGCTGTGGAGTTTCCCAGCGCCCCTCGCGTCCGACCCTTTGAGCGTTCTGCTCC SEQ ID NO:80 GGCGCCAGCCTACCTCCTCCTCGGGCGCC ATGACCACAACCACCACCTTCAAGGGATTCGATCCCAACAGCACGAATAGCTCCCGAGTTGT GCGGACTCCAGCGTGGTGGATCCAATTTTATCATTAGGTTTTGATGAACCAACAGAGCAACC TGTGAGGAAGAACAAAATGGCCTCTAAATATCTTTGGGACACCTGAAGAAGAATCAAGCGTT CTTGGGCCAGAGTCAGTCAGCGTGCCAAGTCTAGATGGTGGCAGGGAACGACTTGGAGTCAT CTGGACTGCATGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGG AGACCGGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGTGGCAGAGTGAT GAGAAGCCCGTGCCTGCTTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCA GAAGAAATCCCCCTGGCGGCAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGGATTTGGTTCCCTTTAAAAAGAAGCACTTTATGTTACT GCTGTCTTTTTTTTTTCCTTTTGACGGCACGGGTTTCCTCTCGGTCCTTGACTCTGGGGGTC TGGGGGCCCAGGGCATGAGTGTTCCTTATATGATGGGGGGAGAGCTTGGGGCCCTTGCACCG GTTTTTCGCGAGCAATATTGGGCCCAGTGGTTAGGCTCTTTGGCCGGGGTTCACCTCTTGGG TTCCCCCCCGGGGGCCAAGGACGCCGTTTGGTC (CloneID 4138051) GCTGCAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTG SEQ ID NO:81 ACCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTCAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTCCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTATCTGTCTCTTGTCCTCCATGCTTGTGAACTGCACAA GTTGAGCCTGACTGTACATCTCTTGGATTCGTTCATTAACAAGAAGCACTTTATGTACTCCT GTCTTTTATTTTCCCTTTGAAGACCCGGTCCCCCCAGGCCTGACCTGGGCTGGCGCCAGGAA GAGGTTCTCATAAAAAAGGGGGGAACACTTGGGACACTAGACTCGGGTTTCGCAAAAATCTG GGTCCAATGTGAAAAGATGGGAGG (CloneID 4766330) GCTGCAGCCGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:82 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TCAGCAAGAACAAAATGCCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAACTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGAAGACTTGGAGTCATCTCGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAACAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCACTGCCATCCAGAAGAAAATCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATCCTTGTGAACTGCACAAT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAACAAGAAGCACCTTTAAACACAAA AAAAAAAA (CloneID 3958097) GTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCAGACCCTTTGAGCGTTCTGCTCCGGCGC SEQ ID NO:83 CAGTCCTATCCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGT GAGGCAAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTG GGCCAAGTCACGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTCGACTG CAGACAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGCAGAAGGTG ATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGCAGTGAACGAGAAGC CCGTCCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAAT CCCCCTGGCGGGAAGTCCAGCCTCGTCTTGCGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAGCTGCACAACT TGAGTCCTGACTGTACATCTCTTGGATTCGTCTCATTGAGAAGAGAAGCACTTTATGTACTG TGTCTTTTCTGTCCTTTGGCGGCCCGGTTCTCTCTGTCTTGACCCTGGGGCGGTGGGN (CloneID 346318 in 3′ to 5′ orientation) TTTTTTTTTTTTTTTTTTTTAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAG SEQ ID NO:84 TCAGGCTCAAGTTCTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGA CAGTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGCGGATTTCTTCTGGATGGCACTGGGGCCGG GGCACCGGGCTCGGGCACAGGCGCANAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTGCC TGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTCTC CGGAGCTTGCTTCAGAGGAGTTCCTTCTCTCCAGTCCAGATGACTCCAAGTCTTCCCTGCCA CCACTNAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCAA AGATATTAGAGGCCATT (CloneID 346318) CGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGC SEQ ID NO:85 CACTANCCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGACTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGCGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGGACTNG CAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAAGAAAGGT GATATTCATG (CloneID 487018 in 3′ to 5′ orientation) AAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCAAGTTGTGCAGT SEQ ID NO:86 TCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAC CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGGCACTGGGGGC CGGGGCACCGGGCTGNGCCACAGGCGCANAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCT GCCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGT CTCCGGAGCTTGCTTCAGAGGACTTCCTTCTCTCCAGTCCAGATGACTCCAAGTCTTCCCTG CCACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCNGGTGTCCC AA (CloneID 487018) CTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGCGTCCGACCCT SEQ ID NO:87 TTGAGCGTTCTGCTCCGGCGCCACTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTTGGAGTCATCTTGGACTT GCAGAGAAGGAACTCCTCTTGAAGCAAAGCTTCCGGAGACTTCTTTAGATCTTGAAGGGAGA AGGTGATATTTG (CloneID 3509038) AGCTAGGTACGAGGCCTGGGTGTTGCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCC SEQ ID NO:88 AGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCG GCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGACTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTCCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGCTCATCTGCACTGC AGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAACGGGCAGAACGGT GATATTCATGAAACATCTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGC CCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAAT CCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTCACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTCATCTCTTGCATTGTTCAC (CloneID 5094728) GCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCCGGTCCGACCCTTTGAG SEQ ID NO:89 CGTTCTGCTCCGGCCCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAACGGAGTCGACCCCAACAGCACGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTCGATGAACCAACAGAACAACCTG TGACGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG CCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA CAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGTTTTCATAGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAG AAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGACCCAGTGCCATCCAGAAG AAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATATGTTTCATTAAACAAGAAGCACTTTATGTAC (CloneID 5590830) GTCCGGAATTCTCCGGATCTCCTGCAGCGGTGGTCGGCTTTTCGGTGTGGAGTTTCCCAGCG SEQ ID NO:90 CCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGC C ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAACAACAAAATGCCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTCG GCCAACTCAGCAGGTCCCAAGTCTACTCGTGGCAGGCAAGACTTGGACTCATCTGGACTCCA GACAACGAACTCCTCTCAAGCAACCTCCGGAGACTTCTTAGATCTCAAGGGAGAAGGTCATA TTCATGAAAATCTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAACCCCGTG CCTGCTGCGCCTGTGCCCAGCCCCGTGGCCCCGCCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAACTCCAGCCTCGTCTTGGGTTAG CTCTGACTCTCCTGAACCCTGTCGTTCTCTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTCACTGTACATCTCTTGGAATTGTTTCATTAAAAAGAAGCACTTTATGTACTCCCT GTCTTTTTTTTTTTTCTTTTGAAAGAACAGGGTTTCTCTCTGCCCTTGACTCTTGGGCTCCG TGCGCCATGGGCATGACGGGTTTTCCCAGTAGTTACATTGGGAGGGCAAACGTCTCTGTGAC CACTTAAATCACCGCCGCTTTTAAACAACAAATTAATTTCGGCTCCCTCAAGGGCCGTTATA ACGTACCCTTTTCTCTCTCTGAGCGCCCTGAAAACTCCTTCACCCCCCGCATGAACGCAGGT TCCCTACTTGGTTCACCACCTCAACCGCTCTGTACCCCCCAGGGGACCCCTGTCTCCCCCCG AGGTGCCCCTCCCTCCCCCCCGGCCCATAATGTTTTCTTCAGCCCAACGAAACTGCCA (CloneID 4550156) GCGGCTCTTCGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCGACCCTTTGACCCTTCTGCTCC SEQ ID NO:91 GGCGCCACCCTACCTCCCTCCTCGGCGCC ATCACCACAACCACCACCTTCAAGGCACTCGACCCCAACAGCAGGAATACCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTCCCACACCTGAAGAAAATCAAGCTTCTTGC GCCAAGTCACCAGGTGCCAACTCTAGTGGTGCCACCGAAGACTTGCAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCACGCAGCCTGCCCCAGAGTGAAGAGAAGCCCGTC CCTGCTGCCCCTGTGCCCAGCCCGGTGGCCCCCGCCCCACTCCCATCCAGAACAAATCCCCC TGGCGGCAACTCCAGCCTCCTCTTGGGTTAG CTCTCACTGTCCTGAACCCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTTCAACTGGCACAA CTTGGAGCCCTGACTGTACATCTCTTGGATTGTTTCATTAAAAAGAAGCCACTTTAAAAAAA AAAAAACCCCTGGAGCACCTACGCAGAGACAGGAGACAAAAAAAATCACAACGCGGGGCCGC CCTTTTGCGGGGGGGCGAAAAACGAGTAAAAAAGGCCCCGGGTCTACAGTGTTGTCCGGACA CCCACTTTGGTCACAAGGGGGAACGCCCCGCCCACAACGGGGGGAAATAAGCAACCGGGGGA TCCTA (CloneID 5258724) GCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCCACCCTTT SEQ ID NO:92 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTCGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTCGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGGTCTGTTTCCTCCATGCTTGTGAACTGCACAAC TTGAGCCTGACTGTACATCTCTTGGATCTGTTCATTAAAAAGAAGCACTTTAAGAAAACCAC ACAAAAAAACTCCGAGGCCACTA (CloneID 3458066) TGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCA SEQ ID NO:93 GCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTGGGACACCTGAAGAAAATCAAGCTTCTGGGCCA AGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGAGA AGGAACTCCTCTGAAGCAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGAATATTCA TGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTG CTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGGCG GCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTCTCGTTCTGTCTGTTTCCTCCATGCTTTGTGAACTGGCACAA CTTTGAGCCTGAGTGTACATCTCCTGTGGTTGTTTCATTAAACAGAAGCACTTTATGTACTG TGTCTTTTTTTTGTCCTTCGGAGACCGGTTCTCTCCGGTCCTGACTCTGCGTCTGGGGGCCG GCTGGGTGTCTAGCGGCACGGCGGGAGCTTGGCCCCTGCCGGCT (CloneID 3940211) TGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTAC SEQ ID NO:94 CTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCCACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTGGGAACACCTGAAGAAAATCAAGCTTCTTGGCC AAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGCAQTCATCTGGACTGCAGAG AAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTC ATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCT GCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGCC GGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGACAATTG AGCCTGACTGTACATCTCTTCGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTGTC TTTTTTTTCTTTCGAAGAACAGGTGCCTCTCTCTCCTGACCCTGGGTCTGGGGCATGCATGG GTGGTTCTAATAGTAATGGGGGAACTGGGACCTTAGACGGGTGTCAGAGACACACGGGTCCA GGTCACGCCTCGGCGGGGTTACACTCAGGGTOCACCGCATGGGCCACAAACCCCGGGCGCTG CGGCCCACAGGGGTCCCGCACCGGGGGCCAACGGGGCGGCACCCGGGAAAAAGAGCGCCTCG CGCAAAAGTGTATACAAGGGGGGAGCGGCGAAGAACTAGACTCCGCGC (CloneID 5015022) GGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGC SEQ ID NO:95 TCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCACGAATAGCTCCCGACTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGACGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGOCAGGGAAGACTTGGAGTCATCTGCACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCCGAGACTTCTTAGATCTGAAGGGACGACCGTGAT ATTCATGAACAATGTGGACACACACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCG TGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGACCCAGTGCCATCCAGAAGAAATCCC CCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTCTGAACTGCACAACT TGCACGCCTGACTGTACATCTCTTGGGATTTGTTTCATTACAAAGAAGCACTTTATGTACAA ACACCATAAAAAAC (CloneID 489924) GGCTGTTGGGTGTCGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCG SEQ ID NO:96 GCGCCACTAGNCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAAGCAGGTGCCAAGTCCAGTNGTTGCAAGGNAGGACTTTGGAGTCATTCTGGGA CTGCAGAGANGGAACTCCTCTGAAGGCAAGCTCCCGGACACTTTCTTAGGATCTTGAAAGGG AGAAGGTGATATNCCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGAAGAGTGAA GAGAAGCCCGTGCCTGCTGCGCCTTGTGCCCAGCCCGGTGGCCCCGGGCCCAGTGCCATCCA GNAAAATCCCCCTTGGCGGAANGTCCAGCTNG TTTNGGGTTAGCNCTGATTTCCTAACGNGGT (CloneID 489924 in 3′ to 5′ orientation) ACATAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCAAGTTGTG SEQ ID NO:97 CAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACACTCAGAG CTAACCCAAGACGACGCTGGACTTGCCGCCAGGGGATTTCTTCTGGATGGCACTGGGGCCGG GGCACCGGGCTGGGCACAGGCGCANAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTGCCT GGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAACTCTCC GGAGCTTGCTTCAGAGCAGTTCCTTCTCTCCAGTCCAGATGACTCCAAGTCTTCCCTGCCAC CACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCAAAG ATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCCTAATG AAAATTGGATCCANCACCTNGAACCCGCAAACTTCGGGAGCTANTCCTGCTGNTGGGG (CloneID 3940896) GCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCGACCCTTTGAGCGTTCTGCTCCGGC SEQ ID NO:98 GCCAGCCTACCTCGCTCCTCGCCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTCGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAACAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGCAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGCAGAAGGTGATA TTCATGAAAATCTGGACACAGACCTTGCCAGGCAGCCTCGGGCAGACTGAAGAGAAGCCCGT CCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCC CTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGACCCTCACTGTACATCTCTTGGATNTGTTTCATTAAAAAGAAGCACTTTATGT (CloneID 4857040) GGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACC SEQ ID NO:99 TCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGCCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTCATGAACCAACAGAACAACCTG TGACGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG CCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAACACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGCTGATA TTCATGAAAATGTGGACACAGACTTGCCAGCCAGCCTGGGGCACAGTGAAGAGAAGCCCGTG CCTGCTCCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TCAGCCTGACTGTACATCTCTTGGATTCGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTAATCCCTTTGGAACGACCAGGTTTCTCCTCTGTCCTTGACTCTAGGGTCCTCTG GGCCATCG (CloneID 3844688) TGTGGGTGTGGAGTTTCCCAGCGCCCCTCGCGTCCGACCCTTTGAGCGTTCTGCTCCGGCGC SEQ ID NO:100 CACCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCAACAGCAGGAATAGCTCCCGAGTTTGC GGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATCAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGGC GGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTCTACATCTCTTGGATTGTCTCATTGAAACCAGAAGCACTTTATGTACTGCT GTCTTTCTTTACCCTTTGGACGGAACAGGTTCCTCTGTCCTGA (CloneID 4797137) AGCGGAGCGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCT SEQ ID NO:101 CGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAACGGTCAT ATTCATGAAAATGTGGACACAGACTTGCCAGCCAGCCTCCGCCAGAGTCAACAGAAGCCCCT GCCTGCTGCGCCTGTGCCCAGCCCGGTCGCCCCGGCCCCACTGCCATCCACAAGAAATCCCC CTGGCGCCAACTCCAGCCTCGTCTTGGCTTAC CTCTCACTCTCCTGAACCCTCTCGTTCTCTCTGTTTCCTCCATGCTTCTGAACTGCACAACT TGACCCTGACTGTACATCTCTTGGCATTTCTCTCCATTACCAAGAACCACTTTTATGTACCT CCTCTCTTTCATCCATTATCACTTTCTGAAGAAACACCTTTTCTCCTCTCTCCTTCACTCCT CCCGCTCTCTGGGCCCTCCCATGACCTGTCCCTAGCACCTCCCTTGGCCCGCGAACGCTTTG TCACACCTAAGTACTGACCATCTCACGAACCA (CloneID 4304080) GGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGCCG SEQ ID NO:102 CCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAACACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGACAAGCCCGTGCT GCTGCGCCTGTCCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGGC GGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTACTGAACCGCTGTCGTTCCTGTCTGTTTCCTCCATGCTTGGTGAACTGACAA CTTGAGCCTGATGTACAATCTCTGGGGATTTGTTTCATTAAAAAGAAGCACTTTATGTAAAA AAAAGTTCACAAAAAAAAATCGGGGCACAAAGAAGGGGGGGAGAAAAGGGGAGGAAGGGGAC ATGGACATAGGTGTTCTGGACAAGTTTTGGCCAGGCGAAATGGGGCCCCAAAGGCGGGATAT GAAAGAAGTAAGTA (CloneID 5928314) GCGGTGGTCCGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGT SEQ ID NO:103 TCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTC TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGCAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTCCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCACCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAACAAGCACTTTATGTACTGCTC TCTTTTTTTTTTTTCTTTTGAAAACAAGTTTCTCTCTGTCCTTCACTCTTGGGTCTGTGGGG CCATGGCATGAGTGGTTTTCTAGTACTAGATTGGAGGGAAAAGCTTTGTGGACACTTTAAGA ACTGGGGTTTTTTAGAAGAAAATAATTTGGGTTTCCGAAGGTGGGTAAAAAGGATCTTTTTG GGAACTGGAGGGGTTTTTAACAACTTTAATTTGGGGGTTTTACCCAAGCCCTCAAACTTCGG ACCGAACCCTTTAAACACGTC (CloneID 6159735) GGACGCCTGGGCGGCTGTTGGCTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:104 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGACGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA CAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATCTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACAACAC CCCAACCCNCCCACCACCCCCCACACCATCAAACAAAGGGGGGGCCGGCTCTAAGAATATCC CCTCGACGGGGCCCAAAGCCTTACCGCGTAACCCCATCTTTTTCTTGGAACAAAAGGGGTTC CCCTTATAGGGGGACGCCGCAAATTATAAAACCTTAGGGCACCCTGCCCCCGCTCCCCTTTT TTTAACAAAACCTCTCGTCGGAATCCCCGC (CloneID 308502) GCTCTTGCCTCTGGAGTTTCCCACCCCCCCTCGGGTCCCACCCTTTGACCGTTCTGCTCCGG SEQ ID NO:105 CCCCACTANCCTCCCTCCTCCGCCCC ATCACCACAACCACCACCTTCAACCGAGTCGACCCCAACAGCAGGAATACCTCCCGAGTTTT CCGCCCTCCAGGTGGTCCATNCAATTTTTCAATTACGTTTTGATGAACCAACACGACCANCT CTTAACAACGACCAAATTCCCCTCCTAATAATCTTTCCGACACCTGAACAAAATCAAGCTTC TTCCCGCCAAGTCAGCACCTCCCAAGTCTAGTCCTCCCAGGGGAAAGACTTCGACTCATCTG CACTTGCAGAGAAGGAACTCCTCTTGAAGCAACCTTCCGGAGACTTTCTTTACATCTTGAAA GCCCACAAAGCTTGATATTCCATGGAAAATGTTGGACACAGACTTTTN (CloneID 308502 in 3′ to 5′ orientation) AAAGTCCTTCTTTTTAATGAAACAAATCCAAGAGATCTACACTCAGGCTCAAGTTGTGCAGT SEQ ID NO:106 TCACAACCATGGAGGAAACAGACACAACGACAGCCTTCACGACAGTCAGAC CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGATTTCTTCTGGATGGCACTGGGGCCGG GGCACCGGGCTGGGCACAGGCCCACAGGCACCGGCTTCTCTTCACTCTGCCCCAGGCTGCCT GGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTCTCC GGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGCCAC CACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA (CloneID 4302544) GGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCG SEQ ID NO:107 CCACCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCCACCCCAACACCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAACAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTCCCAGGGAAGACTTGCAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCCTGACTGTACATCTCTTGGATTGTCTCATTAAAAAGAAGCACTTTATGTTAAACAA AAACAAAAAAAAA (CloneID 3937350) TTGGCTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCC SEQ ID NO:108 AGCCTACCTCGCTCCTCCGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACACCAGCAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCACGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGCCAGAGTGAAGAGAACCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGCATTTGTTTCATTAAAAAGAAGCACTTTATGT (CloneID 3835958) TTCCCAGCGCCCCTCGGGTCAGGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGC SEQ ID NO:109 TCCTCGGCCCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATACCTCCCGAGTTTG CGGCCTCCACGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTCG CGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGACAACTT GAGCCTGACTGTACATCTCTTCGATTTGTTTCATTAAAAAGAAGCACTTTAAAAAAAAAAAA AAAAAAAAAAAAAACCGGGGGACACAAGGGGGGGGGGGAAAAAG (CloneID 5925943) TCGGCTCTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTC SEQ ID NO:110 CGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGCTGCCAAGTCTAGTGGTGGCAGGCAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCACCCTGGGGCAGAGTCAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTANAAAGAAGCACTTTATGTAAAAAAA AAAAAAAAAAA (CloneID 3936327) GTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCCACCCTTTGAGCGTTCTGCTCCGGCGC SEQ ID NO:111 CAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGCAGTCATCTCCACTGCA GAGAAGCAACTCCTCTGAACCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGCGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTCCCATCCAGAACAAATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCCTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTCTTCATTAAAAAGAAGCACTT (CloneID 4100301) GGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCG SEQ ID NO:112 ACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGCAAGAACAAAATCGCCTCTAATATCTTTGGGACACCTCAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCCGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCCGCTGGGGCAGAGTGAAGAGAAGCCCGTGC TGCTGCGCCCTGTGCCCAGCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCCTCGTCTGGGTTAG CCTCTGACTGTCCTGAACGCTGTCGTTCTCTCTGTTTCCTCCATGCTTGTGAACTGCACAAT TTGAGCTTGACTGTACATCTTCTGGATTTGTGTCATTACCACAGACGCCTTTACAAACAGAA AAAAAAATCCGGGGCTTCATTTTCGGGGGGGAACAGGGTATGACG (CloneID 3903688) GTTGGGTGTGGGAGTGTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCG SEQ ID NO:113 CCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTCGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG ACAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAACTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGACAATTG AGCCTGACTGTACATCTCTGGATTGTTTCATTAAAAAAAGAAGCAC (CloneID 4797136) AGCGGAGTCGCCTGTCTTGCTCCGGTAGTTGGCTGTGGACTGACCGCTTTCCCAGCGCCCCT SEQ ID NO:114 CGGGTCCGACCCTTTGATGCGTTGCTGCTCCTGGCAGCCAGCCATACCTCGCTCCTCGGCGG CC ATGACCACAAGCGACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATATGCTCCCGAGTT TTGCGGCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCT GTGAGGAAGAACAAAATGGTCTCTAATATCTTTGGGACACCTGAAGAAACATCAAGCTTCTT GGGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTG CAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGACGCTGA TATTCATGAAAACTGTGGACACAGACTTGCCAGGCAGCCTGGGGCACGAGTGAAGAGAAGCC CGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGGCCCAGTGCCATCCAGAAGAAATC CCCCTGGCGGCAAGTCCAGCCTCCTCTATGGGTTAAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACAATCTCTTGGATTGCTCTCATTACAAACAGAAGCACTTTATGTACTG CTGTACTTCTCATTTTCGTTTTTCCACAACAGGGTTGCCTCTCTGCACTTTGACTCTTTGGG CTCTGTGCGCCCATGGGCATGACTTT (CloneID 4120864) GCTCCTGCAGCGGTGGTCGGCTGTGGGTGTCGAGTTTCCCAGCGCCCCTCGGGTCCGACCCT SEQ ID NO:115 TTCAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGCAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTCGGACACCTGAAGAATCAAAAGCTTCTTGGGCC AAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGAG AAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAACGTGATATTC ATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCACAGTGAAGAGAAGCCCGTGCCT GCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGGC GGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTCACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGGCTGACTGTACATCTCTGGATTGTTCTCCATTAACAAAGAAGCACTTTAGGCAACACC CACCAAAAAC (CloneID 5405894) CTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCT SEQ ID NO:116 TTGAGCGTTCTGCTCCGGCCCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATACCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGCTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGCTCGCCCCGGCCCCAGTGCCATCCAGAAGAAATTCCCC TCGCGGCAAGTCCAGCCTCGTCTTGCGTTAG CTCTGACTGTCCTGAACGCTGTCCTNCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTCGATTCGTTCCCATTAACAAAGAAGCACTTTAAAACAACC CACACACACAACGCGG (CloneID 4276593) GAGCGCCGGCTCCTGCAGCGGTGGTCGGCTGTTGGCTGTGGAGTTTCCCAGCGCCCCTCGGG SEQ ID NO:117 TCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTTGATGAACCAACAGAACAACCT GTGAGGAAGAACAAAAAATGGCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTT GGGCCAAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACT GCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTG ATATTCATGCACAATGTGGACACAGACTTCCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCC CGTGCTGCTCCGCCTGTGCCAGCCCGGTGGTCCGNGCCAGTGCCATCCAGAAGAAATCCCCT GGCGGCAAGTCCAGCTCGTCTTTGGGTTAG CTCTGACTGTGCCTGAACGCTGTCGTCTGTCTGTTCCTCCCATGCTTGTGAACTGACAATTG GGCAGACTGTCATCTCTTGGTATTTGTTCCTTAACAAGAAGCTAAACAAACACAACACACAA AAAATTTTGGCGGGCTGGGGCACGAGAAGTTTAACACCACTCTGGGCGCGCGCCCCAGGTGG AGAAGGGCGCCGCGGTCACGGAACACCGGCAGACGCGGGGGGGGTTCCCACAAAAACGGGGG GCCGGGGGTGAACACCACAGGGGGGGGTCGGTCACACGACCCCACTCAACCCCG (CloneID 4127376) GGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACC SEQ ID NO:118 TCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAACAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTCGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTGGTTTCATTAAAGAAAAACACTTTATGTACACAAC ACACACACAAAAAC (CloneID 5934901) CTGTTGGGTCTCGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGC SEQ ID NO:119 GCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGACTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATCTGGACACACACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCACCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAACTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTANAAACAAGCACTTTATGTAAAAAAA AAAAAAAAAAA (CloneID 4622938) CCACGAGGGGGTGTGGAGTTTCCTACCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCC SEQ ID NO:120 GGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCCACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTCGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTCATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGCCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTCTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTCATCTCTTGGATTTGTTTCATTAAA (CloneID 3909220) TGTGGAGTTTCCCAGCGCCCCTCCGGTCCGACCCTTTGAGCCTTCTGCTCCGGCGCCAGCCT SEQ ID NO:121 ACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAACCTTCTTGG CCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTCGACTGCA GAGAAGGAACTCCTCTGAAGCAACCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGACAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGOTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCTCCATGCTTGTGAACTGGACAACTT GAGCCTGACTGTACATCTCTTGGTTTGTTTCATTAAAAGAAGCACTTTATGGTACTGGCTGG CCTTTTTTTCTTCCTTTCGGACCAACCGGGTTCCTCTTCTGTCCCTGTACTCTGGGGTCCTG GGGGCAGGCTTGGTGTTTCTCGTTGCTTGGGGCGCACAGCTTGTGTCACCTTTTCTGGTCTT TCCAGACCACATTGGGGCCCCGTGTTGGGCTCTGTCGCGGTGTACTTTTGGTTCTGCCCCGG CACTAACCGGTCTCGGCCCCGGGTTCTCCCTGTGGTCTCGGGGGGCCCCTTAAAGCGTCGGC AGTTTAAGGG (CloneID 6061001) TGCTGTTGGGTCTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCG SEQ ID NO:122 GCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAACAAAATCAACCTTCTTGG GCCAAGTCAGAAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGCTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGCTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG CCTTTTTTTTTTTTCTTTTGAAGAACAGGGTTCCTCTCTGTCCTTGACTCTTGGGGTCTCTG GGGCCATGGCATGAGTGGTTTTCTAGTCAGAAGATTGGAAGGGAAGCTTTTGGGACACTTAA CCACTGGGGTTTTTTAAGAAGAAATAATTTTGGTTCCCAGAATGTGTTTACAAGGATCT (CloneID 4604404) GAGCGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGCGTGTGGAGTTTCCCAGCGCCCCTCGGG SEQ ID NO:123 TCCGACCCTTTGAGCCTTCTGCTCCGGCGCCACCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCCACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAACAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTCAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAACCTGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGACGAGAAGCCCGTG CCTCCTGCCGCCTGTGCCCCAGCCCGGTGGACCCGGCCCACTGCATCCAGAAGAAAATCCCC TGGCGGCAGTCCAGCCTCGTACTTGGGTTAG CTCTGACTGTCTGAACGCTGTCGTACTGTCTGTTTCTCCATGCTTGTGAACTGACAATTGAG GCTGACTGTACTTCTCCTGGACTTGGGTTGCATTCAAAGAGGAAAGCACCTTTTATTGTACT TGGATGGGTATCTATAGTATACATATCGTTAGTGAAGAGACAGGGGTTCATATTAGTGTACC TGGACTTTCTGGGGCATTGTGGCGCACTGGATTGAGGTCTATACTAAGAATAAATGAGAGGA AACGGTTGTGACAAGTGTGATGGGATTAGAAGGAGACAATAGATGGGTCCAGAATT (CloneID 4805717) GAGCGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGG SEQ ID NO:124 TCCGACCCTTTGAGCGTTCTCCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCCACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGCATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TTATGAAAAAATGTGGACACAGACTTGCCAGCCAGCCTGGGGCAGAGTGAAGAGAGGCCCGT GCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCC CTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTAC (CloneID 4109734) GGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC SEQ ID NO:125 ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGCACACAGACTTGCCAGGCAGCCTCGGGCAGAGTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTCACAACTT GAGCCTGACTGTACATCTCTTGGATTTGTTTCACTTAAAAAGAAGCACTTTATGTACTGTGT CTTTTTTTTTTCCTTTGGACGACCGGGTTTCTCTCTGCCTTGACTCTTGGGTCTGTGGGCCC TGGCTGAGTGTTCTCATCATGGGGGGCC (CloneID 4553496) GCTGCAGCGGTGCTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCGACCCTTTG SEQ ID NO:126 AGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCACCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGACGGAAGGTGA TATTCATGAAAATGTGCACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCG TGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCC CCTGGCGGCAAGTCCACCCTCGTCTTGGGTTAG CTCTGACTGTCCTCAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGGCACAAG TTGAGCCTCACTGTACATCTCTGGATTGGTCTCATTAAACGAGAAGCACTTTATGTACTGTG TCTTTATTTAGCATTTGAGAACAGGGTGCCTCTTGTCCCTGAATCTGGGTTGGGGGCAGGAT GAGTGTTACTATAGTAATGCGCGAGGTTGGGCACTAGACGGGTTCAGGAAGAATATTGGGGC GATGTGTAAGGATTGGGAGGGGTAACAGTAGGGCGTGACAGCGTAATGGAGGCTATAGTCAG GAGCTGGAGGCCACCAGAGTGGGATTGGTATATGAGGTGAAGCTTGGGTGAAAGGCTCGGAC GAAGTTAGCAGAA (CloneID 4156131) CGGACGGCGTGGGCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGA SEQ ID NO:127 GCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAACGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGCTGCCAACTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACGTGCAG AGAAGGAACTCCTCTCAAGCAAGCTCCGGACACTTCTTACATCTGAAGGGAGAAGGTGCTAT TTATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGCCACAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTGCCCACCCGGTCGCCCCGCCCCAGTCCCATCCAGAAGAAATCCCCCTGG CGGAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTTCCTCCATGCTTGTGAACTGGACAAA TTTGAGCCTGATGGTACATCTCTTTGGATTGGTTCATTAACCAAGAAGCACTTTATGTACGC NGGCCTAGATTCCTGTGAGGACCGGTTCTCTCGTGTCCTGGACCTGGTCGGGGGGCCGGATG AGGGGTCTAGAGGGATCGGGGGGAACGTGCGGACCTAGACGGGGTCGAACAACACTTCGGGC CCACTGGGTGCACAGCTTGGCGGGGGTAACCCAACTGGGGCCCGCCCCGGGGACAAAAAGCA AGGCGGCGGCGCGACCCAGCGCCGCCACCTCGCAAGAGGGGGACCCCAAGAAAAGACCCCGG CGACAGTATTACAACCGAGG (CloneID 5014564) GCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:128 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAPAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTCAAGGGAGAACGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTCTGCCCACCCCGGTGGCCCCGGCCCCAGTCGCATCCAGAAGAAATCCCCCT CGCGGCAAGTCCAGCCTCGCTCTTGGGTTAG TCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCCACCACT TGAGCCTGACTGTACATCTCTGTGGATCGTTTCATTAACNACCGACGCACTTTCATGTCACT GCGTGGTCGTATTGCTTTCCCCCTCTGCGCAGCAACCGGGTTCCTCCTCGGGGCCCTGAACC TCTTGGGACCGTGTGGCCCATGGCCTGAGCGTTCCTACTCGCAACACTCGCCGGCACACCAT CGGCGCACCCGCACCGCCCTTCTCCCGCACAACACACTCGGCTCCCAGGTCTCCACCACCTC CATCCGGCCCCACACACACCATGCCGTCCCCACG (CloneID 3458462) CCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTC SEQ ID NO:129 CTCGGCGCC ATCACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTACGTTTCATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTCAAGAAAATCAAGCTTCTTGCG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAC AGAAGGAACTCCTCTGAAGCAACCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTGCGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTCTCTGTTTCCTCCATGCTTGTGAACTGACAATTG AGCCTGACTGTACATCTCTGGGATTGTTTCATTTACAAAAGAAGCACTT (CloneID 3910873) TCCCAGCGCCCCTCGGGTCCGACCCTTTCAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTC SEQ ID NO:130 CTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCCTG CCTGCTGCGCCTGTGCCCACCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTCCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTCAAAAAGAAGCACTT (CloneID 5928362) CCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:131 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT CCCGCCTCCAGGTGGTGCATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGCGAGAAGGTGATA TTCATCAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAC CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTAAAAAAAAAAA AANAAAAANTAA (CloneID 3904371) CCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCC SEQ ID NO:132 TCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCCAGTTTT GCGGCCTCCAGGTCGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTCGGCCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCCGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAC CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTCGTTTCATTAAAAAAGAAGC (CloneID 4578473) GCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAG SEQ ID NO:133 CGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACACCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTCATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTCAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCACCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGCCCCCGCCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTCGGTTAG CTCTGACTGTCTGAACGCTCTCGTTCTGTCTGTNTCCTCCATGCTTGTGAACTCCACAATTG AGCTGATCTCATCTCTTGGATTTGTTTCATTAAAAGGAGCACTTATGTACTGCTGGCTTTTT TTTCTTGGACACCCGCTCCCCCTGCCTTGCTCTGGGTCTGGGGCACCCTGGAGGGTCCAGTA GAATGGGGAGGAACTGCGACCTTGCGGTTTCGAACAACTCGCCCCTGTTACGACTTGGCGGG GTACCTCCTGGGTCCGCCCTGGCAGAAGCAGGGCTCGCGCCCGAGCCTTGGCACACGGAACC TAGAAAGGCTCGCAATTCACGCCGAGGGTCGGGGGGCTGGG (CloneID 4559434) GGCTCCTGCAGCGGTGGTCCGCTCTCGGTGTGGAGTTTCCCAGCGCCCCTCGGCTCCGACCC SEQ ID NO:134 TTTGAGCGTTCTGCTCCGCCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAACGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTCTT GCGGCCTCCAGGTGGTCGATCCAATTTTTCTTTTAGGTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAACTCAGCAGGTGCCCAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAACACAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCT GGCGGCAGTCCAGCCTCGTCTTGGGTTAC CTCTGACTGTTCTGAACGCTGTCGTCTGTCTGTTTCCTTCCATGCTGTGAAACTGCACAACT TGGAGCCCTGACGTGTACCTCTCTGGGATCGTTCCATTCACCAGAAGCACTTTTATGTGCTG CTGCTATCTTACTCCTGTCCGAGACAGGGTTCTCTCGTCCCTTGACTTCGGGGTCGGGGGCC CCGGCCCTGTCTGCTTCCTGACACATTGGGGGCGAGAGTCTGTCTCCCTGCGACGGGTTCAG ACAGAATCGGGCCAGTCGGTGGAGCGTGGTCGGGACAACTCGGGAACAGCCAGGAGAATAAC GACGCTCGGGCGCCCCAGGCCTCGACTGCGCCTCTCCCGCAACCCCAGACACCCCGCGGAA (CloneID 4547048) GCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC SEQ ID NO:135 ATGACCACAACCACCACCTTCAACGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTC GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAACAACAAAATGGCCTCTAATATCTTTGGGACACCTCAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGCGAGAAGGTGAT ATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGCCAGAGTGAAGAGAAGCCCGT GCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCT GGCCGGCACAGTCCAGCCTCGTCTCGGGTTAG CTCTGACTGTCCTGAACGCTGTACGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAAG CTTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAACGAAGC (CloneID 4276268) GAGCGGCGGCTCCTGCAGCGGTGCTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGG SEQ ID NO:136 TCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCCCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGC GCCAAGTCAGCAGGTGCCAAGTCTAGTGCTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGGAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CTGCTGCGCCTGTCCCCAGCCGGTGGCCCCGGCCCAGTGCCATCCAGAAGAAATCCCCCTGG CGGCAAGTCCACCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTCCTCCATGCTTGTGAACTGCACAATTT GAGCCTGACTGTCATCTCTGGGTTTGGTTCTTTAAACAGAAGCCTTTGTGCGCGGCTTCTTT CTCTCGAGACCACCGTTCCCTGCGCTGGCCCGGGCTCGGGGCCGGCCAGGGTTTCCCCCACT GGCGGCGCCCTCTGGCCCCCCGGTGTCTCCACACAACATGGCGCCCGGTAGGCTCGTCGGCG TACCCTCGTGGCCCCCGG (CloneID 3659047) GTTGGCTCTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGC SEQ ID NO:137 CAGCCTACCTCGTCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGATGTCTGACCCCAACAGCAGGAATAGCTCCCGAGTT TCGCGGCCTCCAGGTGGTGGATCCAATTTTTCATATAGGTTTTGATGAACCAACAGAACAAC CTGTGAGGAAGAACAAAATGGCCTCTAATATCTTGGGGACACCTGAAGAAAATCAAGCTTCT TGGGCCAAGTCATCCAGGTGCCAAGTCTACGTGGTGGCAGGGAAGACTTGCAGTCATCTGGA CTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAACGGGAGAAG GTGATATTCATGAAAATGTGGACACGAGACTTGCCAGTGCAGCCTGGGGCACAGTGAAGAGA AGCCCGTGCCTGCATGCGCCTGTGCCCAGCCCGGTGTGCCCCGTGCCCAGTGCCATCCAGAA GAAATCCCCCGTGGCGGCAAGTCCAGCCTCGTGATTGGGTTAG CTCTGACTGTCCTGAACCCTGTCGTACTGTCTTGTTCCTCCATGCTTGTGAACTGCACAACT TGACCCTGACTGTACA (CloneID 3634373) GGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGC SEQ ID NO:138 CTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAACACTTGGAGTCATCTGGACTGCA GAGAAGGACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAAGAAGGTGATA TTCATGTTTTCATAGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAG AAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGCCCCGGCCCCAGTGCCATCCAGAAGA AATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAATT GAGCCTGACTGTGCTCTCTGGATTTGTTCCTTAACAGAGCCTTTTGTCTGG (CloneID 5741030) CTCCTCCAGCGGTGGTCGGCTGTTGGGTGTGCAGTTTCCCACCGCCCCTCGGGTCCGACCCT SEQ ID NO:139 TTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATACCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACACAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGACTCATCTGCACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAGAAGCACTTTAAAAAAAAAAAAA AAAAA (CloneID 3870232) ATCCCATGACGCCCCTCGGGTCCGACCCTTTGAGACGTTCTGCTCCGGACGCCAAGCCTACC SEQ ID NO:140 TCGCATCCTCGGCGCC ATGACCACAACCAACCACCTTCAAGGGAGTCGACCCCAACACCAGTGAATACGCTCCCGAGA TTTTGCGGCCTCCAGTGTGGTGGATCCAATTTTTCATTAGGTTTGTCATGAACCAACGAGAA CAACCTCTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGC TTCTTGGGCCAAGTCACCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTG GACTGCAGAGAAGGACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAAGGGAGAA GGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAA GCCCGTGCCTGCTCCCCCTGTGCCCAGCCCGGTGGACCCGGGCCCAGTGCCATCCAGAAGAA ATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTCAACGCTGTCGTTCTGTCTGTTCCTCCATGCTTGTGAACTGCACAACTT GAGCCTTGACTGTACATCTCTTGGACTAGGTTCACTTAAAAGAAGCACTTTATGTACTGCTG TCTACAGAAAAACACCCCGGCAGACCGGGTACCCCTACAGGACGTGCACCTTGGGCCAGGGG CCACGGCCAGCCGGGCCACCAGATCCCACACTGGCAGGCAACCCTGCGACACACCACCACCA CGGGAAACACAACACACACAACAGGCCACCGCACGGTAAGAAGGACCTCAGGCCACGAGCAC ACACACAAAACAGGGGGCACAAACCACACGTGGACGACCAAACACCACAGCGACCGAAAGGC GGCCGACAACAGAGACACTCCCCCACACACCGGGTGCCCCAACACCAAACGCATGACAAACA CGTTCAACACACACAAGCCCC (CloneID 3905523) GTGTGGAGTTTCCCAGCGCGGCCTCCGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCACC SEQ ID NO:141 CTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGACTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTACGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCACGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGCAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAACATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAACCCCGT GCCTGCTGCGCCTGTGCCCAGCACCGGGTGCCCCCGGCCCCAGTCCCATCCAGAAGAAATCC CCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACCGCTGTCGTTCTGTCTGTTTCCTCCATCCCTTGTGAACTGCACAA TTGAGCCTGACTGTACCTCTCTTGGATCCGGTTGCCATGCACACAGAAGCGCTGGCGAAAAA GACACCGAGCCGACCACCGACGC (CloneID 5517974) CGGACGCGTGGGCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGA SEQ ID NO:142 GCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAAAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCCATGCTTGTGAACTGCACAAC TTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGCACTGCT GTCTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGGCCTTGACTCTTGGGGTCTGTGG GCCCTGGCATGAGTGTTTTCCTAGAATAGATTGGAGGGAAAGCTTTGTGACACTTAATACTG TGGTTTCAAAAAAAAAATAATTTGGTTCCCAATGTGTTAAAAGGAACTTTTGGTACTGGAGG TTTTTAAAACCTTTAATTTGGGTTTAACCAAGGCCTAACCTGGTACGAACCTTAAAACGTGT CCCACGGGCCCCCGTTTCCTTGGCACGGGCCCAAACCCCACCGGGGGAGGCCTCTCTCACCA AAAACCCTTC (CloneID 4124775) GCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC SEQ ID NO:143 ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGACTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTCTCCTGAACGCTCTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAGAAGCACTTTATGTACTGATGT ACTTCTTATTTTTCCTTTGAAAGAACCAGGTTTCTCTCTGTCCCTGATCTGGTCTGTGGCCC ATGGCACGGAGTGTTCCTTGTAGTACGATTGCGAGGGCAAGCTTGTGAACTATAGTACGGGT TTACGACGAACAATATCTGGCTCCCCAGGTCTCCACGACCTTGACGGGCGTTTCACACCTAC TGGGTTCCCAGCTAGTGGCAGCACAAACGCACAGCCCGGTCGCCAGCCACCCAGAGTTCGGG ACCCTGGTGTGCTATGCAGGCTGGGACACCCTGGATGTCCAAGGGGCCTGCTGCGGAAAGGT TTTATTAGCTAAG (CloneID 5832873 in 3′ to 5′ orientation) TTTTTTTTTTTTTTTTTTAAACTCCTTCTTTTTAATGAAACAAATCCAAGAGATCTACAGTC SEQ ID NO:144 ACGCTCAAGTTCTGCAGTTCACAAGCATGCAGCAAACAGACAGAACGACAGCCTTCAGGACA CTCACAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGCGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGCAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTNCGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGG TCGACTCCCTTGAAGGTGGTGGTTGTGGTCAT GGCGCCGAGGAGCGAGGT (CloneID 4277604) GAGCGGCGGCTCCTGCAGCGGTGGTCGGCTGTTGGGTCTGGAGTCTCCCAGCGCCCCTCGGG SEQ ID NO:145 TCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGACTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGAAGACTTGGAGTCATCTGGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTCAAGGCAGAAGGTGATAT TCATGAAAATCTGGACACAGACTTGCCAGGCAGCTGGGGCAGAGTGAAGAGAAGCCGTGGCT GCTGCGCCTGTGCCCAGCCGGTGGCCCGGGCCCACTGCATCCAGAAGAAATCCCCTGCGGAA GTCCAGCCTCGTTTTGGGTTAG TCTGATGTCCTGAAGCTGTCGTTCTGTCTGTTCCTCAAGGTTGTGACTGACATTGAGCTGAT GTACTTTCTGGATTGTTCATTAAAAGAGCTTTTGAAAAAAAAAAAAAAAAAATTTGGGGGCC GGCCCGAAATTTAACATGGGGGGGGGCCGGGTAGAATGGACGGCAGAAACGGGAAGGGGGTC ACAAAACGGGGAGGTGGAACGGGGGGTAGGTAAGGCGTACAG (CloneID 5834676 in 3′ to 5′ orientation) TTTTTTTTTTTTTTTTTTAAAGAGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTC SEQ ID NO:146 AGGCTCAACTTGTGCAGTTCACAAGCATGGAGGAAACACACAGAACGACAGGGTTCAGGACA CTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGATGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGCTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGG TCGACTCCCTTGAAGGTGGTGGTTGTGGTCAT GGCGCGGAGGAGCGAG (CloneID 5405407) GCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGT SEQ ID NO:147 TCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAAGCAACGCTTCGGAAGACTTCCTTAAAATTCGGACAGGACAAC GGGAGAATATCACAGAGAAATGTGTGGCACACAAGATTGGCCAGGGCACCCGTGGGGCAGAT GTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGGTGGCCCCGGTCCCAGTTGC CATCCAGAAGAGATCCCCCTGGCGGCAAGTCCCAGCCTCGTCTTGGGTTAG CTCTGACTGGTCCTGAACCGCTGTCGTTCTGTCTGTGTCCTCCATGCTTGTGACAGTGCACA CACTCGAGCCTGACTGTACATCTCTCGGATTCGTTACATTCAGAAACAACGCACTTCTATGT ACTGCCTGTCCTTTCTTTCCTTCGCTTTTGGCAGGACCCTGGGTTTCTCTCCTGCCCCTGCA CTCTGGGCCTCCGCTGGCCCCAGGCCCTGTGCTGTCTCCCTACGGCCTCCGCATGCCAGCGA TTCGCCTGGTCGTGACCCTTAGGCCTGGCGTTTTACCCCCG (CloneID 4563923) GCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTT SEQ ID NO:148 GAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGNGTTTTGNATGAACCAANCAGAACAAC CTGTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCT TGGGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACT GCAGAGAAGGAACTCCTCCCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGG TGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGC CCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAAT CCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCAT (CloneID 5533034) CGGCTGTTGGGTCTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCC SEQ ID NO:149 GGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGCGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTCGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGCCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCCTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTCCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTCTTTTGAAGAACACGGTTTCTCTCTGGCCTTTGACTCTTGGGGTCTGTGG GGCCATGGCAATGAATGGTTTTCCTAAGTAGTAAGAATTTGGAGGGAAAAGCTTTTGTTGAC CCCTTAATCAACTGGGGTTTTTTAAGAAGGAAAATTAATTTGGGGGTCCCACAAATGGTGTT TAAAAAGGAATCTTTTTTGGGACCTGGGGCGGGTTTTTTTAACCCCCTTTTTACTTTGGGGG GTTTTTACCCAAGGCCCTTCAAA (CloneID 6060969) AGCGGTGGTCGGCTGTTCGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCG SEQ ID NO:150 TTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTCGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCACGCAGCCTGGGCCAGAGTGAACAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGCCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAACTCCAGCCTCGTCTTGGGCTAG CTCTGACTCTCCTGAAACGCTGTCGNTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAAC TTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAAGAAGCACTTTATGTACTGC TGTCTTTTTTTTTTTTTTCCTTTGAAGAACAGGTTTTCTCTCTGTCCTTTGACTCTTGGGCT CTGTGGGCCATGGGCATGAATTGTTTTTCTACTACTAGAATTGGAGGGAAAAGCTTTTGGGA CACTTAANACTGGGGTTTTTTAAGAAGAAAATAAT (CloneID 3347594) TGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTAC SEQ ID NO:151 CTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAAATAGCTCCCGAGTTTTGC GGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCACAGTGAAGAGAAGCCCGTGCC TGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG CCGGCAACTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCCTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAA (CloneID 3531894) TGTGGGTGTGCAGTTTCCAGCGCCCCTCGGGTCAGACCCTTTGAGCGTTCTGCTCCGGCGCC AGTCTACCTCGCTCCTCCGCGCC ATGACCACAACCACCACCTTCAAGGCAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTAT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTAGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGCTGCCAAGTCTAGTGCTGGCAGGGAACCACTTGGAGTCATCTGGACTGC AGAGAACGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGA TATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCG TCCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGGCCAGTGCCATCCAGAAGAAATCCCC CTGGCGGAAGTCCAGCCTCGTCTTGGGTTAC CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTACTCCATGCTTGTGAACTGACCATCC GAGACTGAATC (CloneID 4276267) GAGGGGGGCCTCCTGTAGGGTGGTCCGTGTTGGGTGTGGAGTGTCCCAGCGCCCCTCGGGTC SEQ ID NO:153 CGACCCTTGAGCGTCTGCTCCGGGCCAGCTACCTCGCTCCTCGGCGCC ATGAGCACAATCCAGCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTT TGCGGCTCCAGGTGGTGGATCCAATTTTTCATTAGGTGTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGGCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGCAGTCATCTGGACTGCAGA CGAAGGAACTCCTCTGGAAGCAAGGCTCCGGAGACTTCTTAGATCTGAAGGGAAGAAGGTGA TATTCATGAACAATGTGGACACAGACTTGTCCAGGCACGCCTGGGGCAAGACTGAAGAGAAG CCCGTGCTTCTGGGCTGTGCCATCCGGTGGGCCCGGCTCCAGTGCTATCCAGAAGAAATCCC CCTGGGGGGAAGTCCAGCCTCGTCTTGGGGTTAG CTCTGACTGTCCTGAACGCTGTCCGTCCTGTCGTCGTTACATCCATGCTTGTTGAACTTGGA CCAACTTGGAGTCTGATGGGAGATCTCCTGGATTGGTTCATTAACCAAAACGCGGTTAGGGA ATGGCCGCCCTTGGGGGAGTCTTCTGACAGACGAAGGTTCACCACTGGGCGAATTCGGCGGG TCGGGGGACAGGAACACAGGGTCCACAGGCAATGGGGCAGACCCATTGTC (CloneID 4547025) GGCGGGTCCGACCCTTTGAGCGTTCCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC SEQ ID NO:154 ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTG CCGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAATCAAAAGCTTCTTGCG CCAAGTCACCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAACAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTG GCGGCAAGTCCAGCTCGTTCTTGGGTTAG CTCTGACTGTCTGAACGCTGTTCGTTCTGTACTTGTTTCCTCCATGCTTGTGAACTGCACAA CTTGAGCTGACTGTACGATCTCTAGGATCTGTCTCATTAAAAAGAAGCCACTTATGTACTGG TGTCTTTTTCACCTTAGGAAAAACAGCTTCCCTCAGGCCTTGACCACTTGAGGTCTGGAGCC AAGCGCATGAAAGGTCCCTAGGCACCCGATCGGAGGGAAACGCCTGCGACCTTACTACCGCA TCTCACACGACACAAGTGCCGTCCCACCTGTCAAAGCACACGTGACCGAGGTCCAACGCATA CCGGTTGCCGCCTAATTGCAGACCAAACGCCCCCACCAGCGCGCCCACACGGACTCGACACT GCTGCAAGGCGACCGCAACCCCTCACACAAACCCCCCTCCCAACAGATATCCAGCGAACCCA CCACGCAGCAAAACGTCCATCACAAAACGTC (CloneID 5314132) AGCGGAGCGGCGGCTCCTGCAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTC SEQ ID NO:155 GGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT CAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAG AGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAACAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTCCCATCCACAAGNAATCCCCCT GGCGGCAAAGTCCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACCGCTGTCCGTTCCTGTCCTGGTTTCCTCCCATGCTTTTTTTTTCT CGTCATCTCGTACGTGAAGGGTGACAGTCACCGACAATACCGTCCGCTGCCGAGAAGACCTC AACGCGACGGAGTAACACAACATCAGCATATACCAATGAACCTTCCCGATGGCGTCAGACTC TCCACGCGACATATACTAGA (CloneID 5576026) CTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCT SEQ ID NO:156 TTCAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATCTGGACACAGACTTGCCAGCCAGCCTGGCGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCCCAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAACACTTTATGTACTGCTG GCCTTTTTTTTTTTCCTTTTGGAAAACAGGTTTCCTCCTCTGTCCTTGAACTCCTGGGTCTT GGGGGCCCAGGGCCTGAAGGGGTTTTAATTATCAAACTTGGAGGGAAAACCTTTTGGACACT CTTTACTTGGGCCTCTTCACAAAACACCACCTCGGTCCCCACAAGGGGTTCGACGGCCTCTT TTGTCACGAAGGTTTCCCCAATTTAATATTTGGGCGTTCCATAAACCTCCATTGGCGACGGC CCAATACACCGGCCATACGGCCGCCGCTCCTTGTCTAATCCCGCCCCCGGATGGGAGGCTCT TCTTCCAGAGGCCCTCATTGGGGCGGCCCCCGCTCTATCACAGC (CloneID 5165195) GCAGGACAGGCGGCAGCCGCGGCTCCTGCAGCGGTGGTCTGGCTGTTGGGTGTGGAGTTGGG SEQ ID NO:157 GAGCGCCCCTCGGGTCCGAGCCTTTCAGCTGTTCTGCTCCGGATGCCAGCCTACCTCGCTCC TCGGCCCC ATGACCACAACCACCACCTTCAAGGGAGTCAGAACCCAACAGTCAGGAATAGCTCCCGAGTT TTCCGCGCCTCCAGGTGTGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAA CCTGTGAGGAAGAACAAAATGGTCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTC TATGGGCCAAACTCACGCAGCTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTG GACTGCAGAGAAGGAACTCCTCTGAAGCAAGCATCCGGAGACTTCTTACATCTGAAGGGAGA AGGTGACTATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAG AAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCTGGTGGACCCTGTGCCCAAGTGCCATCCAG AAGAAATCCCCCTGGCGGCAAGTCCAGAACTCGTCTTGGGTAAG CTCTGAACTGTACCTGAACCGCTCTCGTTCTGTCTGTATCCTCCATGCTTGTCAACTGCACA ACTTGAGCCTGACGCTGTACATTCTCCTGGGGATTTCGCTTCCCACTTAAAAAAGACGCCAC TTCACTGTTACCAGCGAAAAAAGGCAGCAGCGAGAACAGAACAAACAATTGGTGAG (CloneID 3449557) GTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGC SEQ ID NO:158 CAGCCTACCTCGCTCCTCGCCGCC ATGACCACAACCACCACCTTCAAGGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTT TGCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTCGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAACCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCCGTGGCCCCGGCCCAGTGCCATCCAGAAGATATCCCCCT GGCGGCAAGTCCAGCCTCGTCTTCGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTTGTCTTGTTTCCTCCCATGCTTTGTTGAACCTGC ACAAACTTGAAGCCCTTGACGTGGTACAATCTCCTTGGAGTTTGTGTCCACTTTAAAACGAA GCACTTTTTAAATAG (CloneID 3351305) GCTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGTGCGCCAG SEQ ID NO:159 CCTACCTCGCTCCTCGCCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAACTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAACGGAGAAGGTCATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTCGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCCCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAATT TGAGCTGACTGC (CloneID 3029189) TTGGCTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCC SEQ ID NO:160 AGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCCGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATCCTT (CloneID 5465786) GCTGTTCGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCCACCCTTTGAGCGTTCTGCTCCGG SEQ ID NO:161 CGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAACACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTCCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCCCTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTAAAAACAAAAA AAAAAAAAACTCGA (CloneID 2819762) GGC SEQ ID NO:162 ACGAGGACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGCAAGACTTGCAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAACCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTCTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGGTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTANNAAAAANAA AAANNAAA (CloneID 2819762 in 3′ to 5′ orientation) TTTTTTTTTTAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCAA SEQ ID NO:163 GTTGTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCCGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTCCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTTGGATCCACCACCTGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGG TCGACTCCCT (CloneID 2819763) GGC SEQ ID NO:164 ACGAGGACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTCCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAAAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCAT (CloneID 2819763 in 3′ to 5′ orientation) TTTTTTTTTTAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCAA SEQ ID NO:165 GTTGTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACGAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGGCTGGGCACAGGCGCAGCAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGGT CGACTCCCT (CloneID 3912245) GGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGC SEQ ID NO:166 CTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACACACTTGCCAGGCAGCTGGGGCAGAGTGAAGAGAAGCCCGTGC CTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCT GGGCGGCAAGTCCAGGCTCCGTCTTGGGGTTAG CTCTGACTGGTCCTGAACGCTGTCGTTCTGTCTGGTGTCCTCCATGCTTTGTGAACTGGGCC CAATTTGAGGCCTGGAGTGGTGCCTCTCTTGGGTTTTGGTGCCTCTTAAGGAAGCCTTTTTT GTCCGGCGGCCCTTGCCCTTTGCGGCACCCGGTGTTCTCCTGCCCTACACCGCGGGCGGGGG CCCGG (CloneID 5164014) C SEQ ID NO:167 CGGCGGCCTCCTTACCCTCGCCCTGCCCCCACTCCTTATTCGCACCTACCTCACAGAGTTTT GCGGCCTCCAGGTCGTGGATCCAATTTTTCATTAGGTTTTCATGAACCAACAGAACACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAAGTCAGCAGGTGCAACTCTAGTGGTCGCAGGGAACACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATT CATGAAAATCTGGACACACACTTGCCAGCCAGCCTGGGGCAGACTGAAGAGAAGCCCGTGCC TGCTCCGCCTGTGCCCACCCCGGTGCCCCCGGCCCCAGTGCCATCCAGAACAAATCCCCCTG GCGCCAAGTCCAGCTCCTCTTGGGTTAG CTCTCACTGTCCTCAACGCTGTCCTTCTGTCTCTTTCCTCCATGCTTGTGAACTGCACAACT TCAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAACAGAAGGCACCCTTTAATAAA CAAACACAAGAACACAGAACAAAACACAACAAAGAACAACGGCGGG (CloneID 4284754) GAGCGGGGCTCCTGCAGCGGTGGTCGGCTGTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTC SEQ ID NO:168 CGACCCTTTCAGCGTTCTGCTCCGGCGCCACCCCTACCTCGCTCCTCGGGCC ATGGACCACAACCACCACCTTCAAGGGACTCGACCCCAACAGCAGCAATAGCTCCCCAGTTT GGCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTGTGGCACACCTGAAGAAAATCAAGCTTCTGG GGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCACCGAAGACTTCGAGTCATCTGGACTCC ACACAAGGAACTCCTCTGGAGCAAGCTCCGGAGACTTCTTACATCTGAAGGGAGAAGGTGAT ATTCATGAACAATGTCGACACACACTTGCCACGCCGCCTGCCCGCACGACTCAAGAGAAGCC CGTGCCTGCTCCCCCTGTGCCCAGCCCGGTGCCCCGGCCCCAGTGCCATCCAAGAATCAAAT TCCCCTGCGGGCAGAGTCCAGGCCTCGTCTTGGGTTACG CTCTGACTGTCTGAACCGCTGTCGTTCTGGTCTTGTTTTCTTCCATGCTGTGTCAACGTGGA CAACTTTGAGGCCTTGATGTACATCTCTGGATGTGTTCACTTAAAAAGAGCAATTATGTATC GGTGCCTTTTCATTTCCTTGGACAAACCGGTCTCTCTGACTTCAACTGGGGTTGGGGCAGGC ACCACGATGTTTCAACACAATGGAGCACCN (CloneID 428337) GAGCGGCGGCTCCTGCAGCGGTGGTCCCCTGTTGGGTGTGGAGTTTCCCAGCCCCCCTCGCT SEQ ID NO:169 CCGACCCTTTGAGCGTCTGCTCCGCCGCCAGCCTACCTCGCTCCTCGGCCCC ATGACCACAACCACCACCTTCAACGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAACAACAAAATGGCCTCTAATATCTTTCCGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGAAGACTTGGAGTCATCTGGACTGCAG ACAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATAT TCATGAACCATGTGCACACAAGACTTGCCAGGCAGCCTGGGGGCAGAGTGAAGAAGAAGCCC GTGCCTGCTTGCGCCTGTGCCCAGCCCGGGTGGCCCCGGCCCCCAGTGCATCCAGAAGAAAT CCCCCTGGGCGGCAAGTCCAGCCTCGTCTTGGGTAG CTCTGACTGTCTGACGCTGGCCTCTGGCTGTTCCTCCTGCTTGTCAACTGCACACTTGAGCC TGACTGGACATCTCTTGGATTCGTTCATAAAAGGAGCTTGCAAAAACAAAAAAAAATTTGCG CGCCCCCCAAATTTTAACTCTTGGCGCCCCGGTGAATGGCGCGCCAGACCGCACAGGGGTCA CAAACCGGGCGGCGAAACAGGGGTTGTCGCCACACCCCGG (CloneID 5936059) AGCGAGGCCTGGGTGGCGATCCAAGACGAGGCTGCAGCGGTGGTCGTCTGTTGGGTGTGGAG SEQ ID NO:170 TTTCCCAGCGCCCCTCGGGTCCCACCCTTTGAGCGTTCTGCTCCGCCGCCAGCCTACCTCGC TCCTCCGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGCAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTCATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTCGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGCGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCGGTTTCCCTCCATGCTTGTGAACTGCACAAC TTGAGCCTGACCTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTAAGGACTGC TGGCCTTTTTTTTTTTTCTTTTGAAAAACAGGTTTCCCCCCGGCCCTTTGATCCTTGGGGTC TGGGGGCCCATGGGAATGAAATGGTCTTCTAACTAACAACATTGGGAAGGAAAAAGCCTTGG GGACACCTCAACAACGTGGGGTTTTTAAAAAGAAAAAAAATTTGGCTTCCCACAGGGGGTTA AAAGGAATCTTTTTGTACCCGAAGGGTTTTTAAACCCTTTTACCTGGGGGGTTACCCAGGCC CTCCCACTTGGCACCGGAACCATTTAACCGGTCTCCAGAGGGGCCCCGTTTCCCGGGCCAGA CCCCCCCACCCTCACAGGGGAAGTCTCTCCTCCCCAAAAAACTCTCCCTTGGGGGGTGGGCT CCCCTACCTTTCGCCCGTGGGGCCCTTTTGTCACAAA (CloneID 4280999) GAGCGGCGCCTCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTCTCCCAGCGCCCCTCGGG SEQ ID NO:171 TCCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTGATGAACCAACAGAACAACCTGT GAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGG CCAACTCAGCAGGTGCCAAGTCTAGTGGGTGGCAGGGGAACGACTTGGAGTCATCTGGACTG CAGAGAAGGAACTCCTCTGAAGCAACCTCCGGAGACTTCTTAGATCTGAAGGGAGACGGTGA TATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCG TGCCTGCTGCGCCTGTGCCCAGCCCGGTCGGCCCGGCCCAGTGCCATCCAGAAGAAAATCCC CCTGGCGGGCAACTCCCAGCCTTCCGTCTGTGGGGTTAAG CTCTTGACTGGGTCCCTGAACGCTGTCCGTTCCTGTCTGTTTTCCCTCCCATGGCTGGTGAA CTGGACCAACTTTGAGCCTGACTTGTACATTCTCCTGGGATTCGTCTCCTTTCACCCAGAAG GCCTTTATGACACACAACAACACTCCAAACACACCTTGGGCGCCGCGCGCCCCTCACACATT TTAAACCCTCTGTGCGGCCGGCCCACGGTAGGACAGGGCTAGGCCCGGCAACGGGAGGGACG GTGGTTACCAAAACCCGGGCGGGCTGCCCCACGGTCCGCTCG (CloneID 6154219) GGACGCGTGGGCGGACGCGTGGCCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGA SEQ ID NO:172 CCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAGCAAGCTCCGGAGACTTCTTAGATCTGAAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACCCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTCCACAACT TGAGCCTGACTGTACATCTCTTGGGGATTTGTTTCATTAAAAAAGAAGCACTTTTATGTACT GCTGGNCTTTTTTTTTTTTTTCTTTTTTGAAGAACAGGTTTTCTCTCCTGTCCCTTGACTCC TTTGGGGTCTGTTGGGCCCATGGGGCATGGAGTTGGTTTTCTAAGGTAAAGTAGAAATTGGG GAGGGGGAAAAGCCTTTTGGTGGACACCCTTTT (CloneID 4045037) GGCGGGGCTCACTGACAGCGGTGGTCGGGTGTGGGTCTGGAGTTTCCCAGCTGGCCCCTCGG SEQ ID NO:173 GTGCGACCCTTGTGAGCGTTTCTGCTCCGGTCGCCAGTCGTTACCTCGCTCCTCGGGCC ATGACCACAAGCACCAGCTTCAAGGGAGTCGATCCCAACAGCAGGAATAGCTCCCGAGTGTA GCGGTCTCCAGGTGGTGCATCCAATTCACATCAGGTTTGATGAACCAAGAGAACAACCTGTG AGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAACCTTCTTGGGC CAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCACGGAAGACTTGGAGTCATCTGGACTGCAGA GAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGACACGGTGATATT CATGACAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCCAGAGTGAAGAGAAGCCCGTGC TGCTGCGCCTGTGCCAGCCCGGNTGGCCCGGCCCAGTGCCATCCAGAAGAATCCCCTTGGGG AGTCAGCTCGTCTGGGTA (CloneID 6048028) CCACGCGTCCGCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGT SEQ ID NO:174 CCGACCCTTTCACCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGCACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCCGAAAAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAA CTCTGACTGTCCTGAACGATGTCGGTCTGGCCTGTTTCCTCCATGCTTGGGAACTGCACAAC TGGAGCCTGACTGTACATCTCTTGGAATTGGTTTCATTAAAAAGAAACACCTTTAAAAAAAA AAAAAAAAAGGGGGGGCCGCTCCAAAAGGAT (CloneID 2518214) GAGCTCAAGGATCCTTAATTAAATTAATTCCCCCCCCCCCCGAGCGGCGGCTCCTGCAGCGG SEQ ID NO:175 TGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCCGACCCTTTGAGCGTTCTG CTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGNGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCAGTGGCCCCGGTCCCAGTGCCATCCAGAAGAAATCCC (CloneID 2820804) GGCACGAGGCCTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTC SEQ ID NO:176 CGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATC (CloneID 2519633) AGCGGCGGCTCCTGCAGCGGTGGTCGGTTGTTTGGTGTGGAGTTTCCCAGCGCCCCTCGGGT SEQ ID NO:177 CCGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAACGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACCAGAACAACCT GTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTG GGCCAAGTCAGCAGGTGCCAACTCTAGTGGTGGCAGGGAACACTTGGAGTCATCTGGACTGC AGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAACGTGAT ATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTG (CloneID 2518293) AGCGGATCCTTATATTAAATTAATTCNCTCCCCCCCCCCCAGAGCCGGCGNNNGCTCCTCCG SEQ ID NO:178 GAGCGTGTGTGTCGGCTTTGTTGGGATGTGCGAGCTTTCCCCAGCTGCACCCTTCGGAGTCC CGACGCCTTTTGANNGCGTTCTGCATCCCGGCGCCCAGCCCCTACTCTCGCTCCTCTGGCGC CC ATGANCCACTATACCACCACCTTCAACTGTGAGTCGACCCCAACNATCCAGGAATAGCTCCC GAGTTTTCGCGGCCTCCACCTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGA ACAACCTGTGACCAAGAACAAAATGGCCTCTAATATCTTTGCGACACCTCAAGAAAATCAAG CTTCTTGCGCCAAGTCAGCACGTGCCAAGTCTAGTGGTGCCAGGGAACACTTGGAGTCATCT GGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGA AGGTGATATTCATGAAAATCTGGACACAGACTTGCCAGCCAGCCTGNCGCAGAGTGAAGAGA AGCCCGTCCCTGCTGCGCCTGTGCCCACCCCAGTGGCCCCGGTCCCAGTGCCATCCAGAAGA CATCCCCCTTGCGGCAAGTCCAGCCTCGTCTTG (CloneID 2819423) GGCACGAGCCCTGCAGCGCTGGTCGGCTGTTGGGTGTGCAGTTTCCCAGCGCCCCTCGCGTC SEQ ID NO:179 CGACCCTTTGAGCGTTCTCCTCCGGCGCCAGCCTACCTCGCTCCTCCGCGCC ATGACCACAACCACCACCTTTAAGGCACTCGACCCCAACAGCAGGAATAGCTACCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGCAAGAACAAAATCGCCCCTAATATCTTTGGGACACCTGAACAAAATCAACCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTCGTGGCAGGGAAGACTTGGAGTCATCTCGACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCC (CloneID 2819397) GGCACGAGGCCTGCAGCGGTGGTCGGCTGTTCGGTGTGGAGTTTCCCAGCGCCCCTCGGGTC SEQ ID NO:180 CGACCCTTTGAGCGTTCTGCTCCGGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGCGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGGCCCCTAATATCTTTGGGACACCTGAAGAATCAAAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGCGAAGACTTGGAGTCATCTGCACTGCA GAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTATATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGGCC (CloneID 2783324) CGAGCCGCGGCTCCTGGAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGG SEQ ID NO:181 GTCCGACCCTTTGAGCCTTCTGCTCCCGCGCCAGCCTACCTCGCTCCTCGGCGCC ATGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAAAACAAAATGGCCTCTAATATCTTTGCGACACCTGAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCACGTGCCAAGTCTAGTGCTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA AAGAATGAACTCCTCTGAACCAAGCTCCGCACACTTCTTACATCTGAAGCGACAAGGTGATA TTCATTAAAATGTGGACACACACTAGCCATCCAGCCTGTCCCATAGTGAATAGAAGCCCGTG CCTGCTGCTCCTGTGCCTATTTCAGTTCATCCAGCACACGCACCGTCCACAACAAATCCCGC TGGGGCAACTACAGGCTTGATT (CloneID 471568 in 3′ to 5′ orientation) TTACATAAAGTGCTTCTTTTTAATGAAACAAATCCAACAGATGTACACTCAGGCTCAAGTTG SEQ ID NO:182 TGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACCAGGCTGGACTTGCCGCCAGGGGATTTCTTCTGCATGGCACTCGGGCCGG GGCACCGGGCTTGGGCACAGCCGCANAGGCACGGGCTTCTCTTCACTCTGCCCCAGGCTGCC TGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAAGTCT CCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTTGCAGTNCAGATTGACTCCAAGTCTTCCCTG CCACCANTAGACTTTGGCANCTGCNGACTTTGGNCCAACAAAGTTGAATTTCTTCAAGNGGT CCCAAAGATTT (CloneID 471568) CTGCAGCGGTGGTCGGCTGTTGGGTGTGGAGTTTCCCAGCGCCCCTCGGGTCTCGACCCTTT SEQ ID NO:183 GAGCGTTCTGCTCCGGCGCCACTACCTCGCTCCTCGGCGCC ATCACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCAGGAATAGCTCCCGAGTTTT GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TTG (CloneID 4080434) GACCCCAACAGCAGGAATAGCTCCCGAGTTTTGCGGCCTCCAGGTGGTGGATCCAATTTTTC SEQ ID NO:184 ATTAGGTTTTGATGAACCAACAGAACAACCTGTGAGGAAGAACAAAATGGCCTCTAATATCT TTGGGACACCTGAAGAAAATCAAGCTTCTTGGGCCAAGTCAGCAGGTGCCAAGTCTAGTGGT GGCAGGGAAGACTTGGAGTCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGG AGACTTCTTAGATCTGAAGGGAGAAGGTGATATTCATGAAAATGTGNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN N NNNNNNNNNNNNNNAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTCCTTTGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTGGGGTCTGTGGG CCATGGCATGACTGTTTCTAGTAGTAATGGGAGGGAAAGCTTGGTGACACTTAGTACTGTGT TTTTAAGACGAAATAATTGGGTTTCCAGATGTGTCACAGGATCTTCGTACTGAGGTTTAACA CTTTACTGGGGTTTACCAAGCCTCAATGGAAGACATAACAGTCACAGGCCCGTCTGCAGGCC AACCAAGGGAGTTCTCCGAGACCTCTGTTCTGCCTAATGCCATGGCTTGTCAAAGCCCTCTG GCTGGC (CloneID 4748522) CGAGTTTTGCGGCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAA SEQ ID NO:185 CAACCTGTGAGGAAGAACAAAATGGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGC TTCTTGGGCCAAGTCACCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGCAGTCATCTG GACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAA GGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAA GCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAA ATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACCCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTATTCCTTTGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTGTGGGTCTGTG GGCCATGGCATGAGTGTTTCCTAGTAGTAGATGGGAGGGAAACCTTGGTGACACTTAGTACT GTGTTTTCAAGAAGAAATAATTGGGTCCCAGATGTGTTAGAGGATCTTGGTACTGAGGTTTT TAACACTTTACTGTGGCTTTACCAAGCCTCAACTGGACAGACCATAAA (CloneID 5187032) CTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGGCCAAGTCAGCAGGTGCCAAG SEQ ID NO:186 TCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGACAAGGAACTCCTCTGAAGC AAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTCATGAAAATGTGGACACAG ACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGC CCGCTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGT CTTGGGTTAG CTCTGACTGTCCTCAACGCTGTCCTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTC TCTTTTTTTTTTTTCCTTTGGAAGAACAGGTTTCTCTCGTGTCCTTGACTCTGGGGTCTCGG GCCCAGGGCATCAGTGTTCCATAGTAGTAGATGGGAGGGAAAGCTTGGCGACACTTAGTACG GGGTTTTCAACAAGAAATAATCGGGTTCCAGAGTGTGTAAGAGGACTCTTGGGTACGCAGGT TAAAACACTTAACTGGGGTATACCAAGCCTCAACGCGACAGACCATAAACGGTCCACAGGCA CCGTTCCGTGCAGGGCCCAAGCCAAAGGGAGTCTCTCCGAAGAGCCTTCTGGGAGTAGCCCT AACTTTGCCAGGTGGCCTTGGGTCAAGAGCCTCCTCCTGTGACCTGGTCA (CloneID 3895688) AATATCTTGGGACACCTGAAGAAAATCAAGCTTCTTGCGCCAAGTCAGCAGGTGCCAAGTCT SEQ ID NO:187 AGTGGTGGCAGGGAAGACTTGGACTCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAG CTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTCATATTCATGAAAATGTGGACACAGACT TGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTCCGCCTGTGCCCAGCCCG GTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTT GGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTCCTTTGGAAGAACAGCTTTCTCTCTGTCCTTGACTCTGGGGTCTGTGGG CCAGGGCATGAGTGTCTCTAGTAGTAGATCGGAGGGAAAGCTTGGTGACACACTTTACTGGG GTTTACCAAGCCTCAACTGACAGACCATAAACAGTCCACAGGCACCGTTCCTGGCAGGCCCA ACCCAAGGGAGTCTCTCCGAGAGCCTTCTGGGTGTGGCCTAACTTGCCAGGGGCCTGGCTCA GAGCTCCTCTGTGACTGTGACACTGAGCAG (CloneID 3938961) AATCAAGCTTCTTGGGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGCAAGACTTGGAG SEQ ID NO:188 TCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAA GGGAGAAGGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTG AAGAGAAGCCCGTGCCTCCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCC AGAACAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTCTCCTTGACTCTGTGGGTCTGTGGG CCAGTGGCATGAGTGTTTCTAGTACTAGATGGGAGGGAAAGCTTGGTCACACTTAGTACTGT GTTTTTAACGAAGAAATAATTGCTTCCAGATGTGTTAGAGGATCTTTCTACTGAGCTTTTTA ACACTTTACTGTGGGTTTACCAAGCCTCAATGGACAGACCATAAACACTCCACGAGGCACCG TTCCTGCCAGGCCCAACCCAAGAGGGAGTCTCTCCGAAGAGCCTTCTGTGGTGTTGGCCCTA ATTTGCCAGGTGGCCTTGGTCAGAGCTCCTCTGTGACTTGTGGACCATGGAAGGGCTGGGCT CTTGCTTGCGGCTGGAAACGAAAGAATGGCTTTATTTTTAACCTTAAAGTAGCAGATATGTA ACAAGATGGTGGCGTGTTACAA (CloneID 4345766) GAAGAAAATCAAGCTTCTTGGGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGA SEQ ID NO:189 CTTGGAGTCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAG ATCTGAAGGGAGAAGGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGG CAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTCGCCCCGGCCCCAGT GCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTCTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGACCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTCCTTTTGAAGAACAGGTTTCTCTCTGTCCTTCACTCTGGGGTCTGTGGG CCATGGCATGAGTGTTTCCTAGTAGTAGATGGGAGGGAAAGCTTTGTGACACTTAGTACTGT GTTTTTAAGAAGAAATAATTGGGTCCCAGATGTGTCAGAGGATCTTTGGTACTGAGGTTTTT AACACCTTTACTGTGCGTTTACCAAGCCTCAACTCGACAGACCATAAACAGTCCACAAGGCA CCGTCCTGCCAGGGCCGAACCACAGGGAGTCTCTCCGCAGAGGCTTCTGGTGTTGCCTACTT GCCAGTGGCCTTGTCAGAGCCTCTCCTGTGACATGTGAACACACGAAAAGCCTCGGCCACTG ACTTGAGTGTGAAGA (CloneID 3889866) TGGAGTCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGAT SEQ ID NO:190 CTGAAGGCAGAAGGTGATATTCATGAAAATGTGGACACACACTTGCCAGOCAGCCTGGGGCA GAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGC CATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTGGGGTCTGTGGG CCATGGCATGAGTGTTTCCTAGTAGTAGATGGGAGGGAAAGCTTGGTGACACTTAGTACTGT GTTTTAAGAAGAAATAATTGGGTTCCAGATGTGTCAGAGGATCTTNGTACTGAGGTTTTAAC ACTTTACTTGGGTTTACCAAGCCTCAATGGACAGACCATAAACAGTCCACCAGGCACCGTTC CTGCCAGGCCAACCCAGAGGGAGTCTCTCCGCGAGAGCCTTCTGTGGTGGTGGCCCTAACTT GCAGTGGCTGGTCAGGAGCCCTCCCCTGTGACCTGTGACCCATGAAAGGCTGGGCTCTGCTG CCGCTGAAGAAAAACGCTCTTATTTTACCTAAAAGTCCATTTACCGACGCGCGGTGACCCAC TGTCCCCCAGAGGCGGGGTCACAACGCCCGACACACCGGCACGGGGCCCGAGGCGCCCAGGC CCGTCGAAACATGTGCGCCGAAACACCGGCGCAGGCCA (CloneID 4450834) TCTTAGATCTGAAGGGAGAAGGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGC SEQ ID NO:191 CTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGC CCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTGGGGTCTGTGGG CCAGTGGCATGAGTGTTTTCTAGTAGTAGATGGGAGGGAAACCTTGGTCACACTTAGTACTG TGTTTTTAAGAAGAAATAATTGGGTTCCAGATGTGTTAGAGGATCTTTGGTACTGAGGTTTT TAACACTTTACTGGCGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACAGGCACC GTTCCTGCCAGGCCCAACCCACAGGGAGTCTCTCCGAGAGCCTTCTGTGGTGTGGCCTAAAT TGCAGTGGCTTGTGTCAGAGCTCCTCCTGTGACATGTGACATGAAGAGGGCTCGGCTCCTGG CTTGGCGGCTGAAAGGAAAGAAACTGGCTTTATTTTTTAACCTTTAAAAGGTTGCGGATAGT AACAAGATTGGGTGGGTGATGAGAAGGCTTGGTCTCAGCAACAGAGGTGGTTCAATGAAATG CTGGATAAAAGCGTGACAG (CloneID 5521426) TTACCAACAGAACAACCTGTGAGGAAGAACAAAATGGCCTCTAATATCTTNTGGGACACNCT SEQ ID NO:192 GAAGAAAATCAAGCTTCTTGGGCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGA CTTGGAGTCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAG ATCTGAAGGGAGAACGTGATATTCATGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGG CAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGCCCCCAGT GCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAC CTCTGACTGTCCTGAACGCTCTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGG CCATGGCATGAGTGTTTTCTAGTACTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGT GTTTTTAAGAAGAAATAATTTGGTTCCAGATCTGTTAGAGGATCTTTTCTACTGAGGTTTTT AACACTTTACTTGGGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACACGCACCG TTCCTGCCAGGCCCCAACCCACAGGGAGTCTCTCCGCAAGCCCTTCTTGGTGTTGCCCTAAC TTGCCAGTGGCCCTTTGCTCAGAGCCTCCCTCCTGTGACATGTGGAAACATGAAAGAGGCCC TGCGCCCTCCCTGGCTTTTCCCGGCTTGCAAAGAAAAGAAACTGGCCCTTTTTATTTTTTTA ACCCTTTAAAAAGGAGGCCAGAATAAGTAACCAGAACTTGGCCTGGGCTTGATGTAAACCAA AGCCCTTTGGTTCTCCCACCCCAAAACGAAAAGGCTTTTGGGT (CloneID 5267723) AGCGGGCGTAGCCATTGGATCCGGAGACCGGATCGATCAGAGTTTTGCGGCCTCCAGGTGGT SEQ ID NO:193 GGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTGTGAGGAAGAACAAAAT GGCCTCTAATATCTTTGGGACACCTGAAGAAAATCAAGCTTCTTGGCCCAAGTCAGCAGGTG CCAAGTCTAGTGGTGGCAGCGAAGACTTGGAGTCATCTGGACTGCAGAGAAGGAACTCCTCT CAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTCATGAAAATGTGGA CACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGC CCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGC CTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAACAAAGAAGCACTTTATGTACTGCT GTCTTTTTTTTTTTCCTTTGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTGTGGGTCTGTC GGCCATGGCATGAGTGTTTCCTAGTAGTAGAT (CloneID 4441495) CAGGTGCCAAGTCTAGTGGTGGCAGCGAAGACTTGGAGTCATCTGGACTGCAGAGAAGGAAC SEQ ID NO:194 TCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTCATGAAAA TCTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTCCTGCGC CTGTGCCCAGCCCGGTGGCCCCCGCCCCAGTGCCATCCACAAGAAATCCCCCTGGCGGCAAG TCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGC CATGGCATGAGTGTTTTCTAGTAGTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGTG TTTTTAAGAGAAATAATTTGGTTCCAGATGTGTTAGAGGATCTTTGTACTGAGGTTTTTTAA CACTTTACTTGGGTTTACCAAGCCTCAATCTGGACAGACCATAAAACAGTCCACAGGCACCN GTTCCTTGCCAGGGCCCCAACCCACAGGGAGTCTCTCCCGGCAGAGCCTTTCTTGGTGTTTG CCTTAAATTGGCAAGTCGGCCTTGGTCAAAGCCTCTTCCTGTGCATGTGAACACTGGAAAGA GGCTGGGGCCTCCTGCCGTTGGCGGCTGGCAAAGAAAAAAGCCGTTTTTTTTACCTTAAAGT GCCCAAGTTAACAACGGGTGGTGTTGGAAACCTTGTTTCCCCAGAAGGGGGTGTGAAAAGGG GGGTACACAGGAACAGGGGAAGCACAGGTCTCTCAACAGAGCACG (CloneID 5395070) TGACCACAACCACCACCTTCAAGGGAGTCGACCCCAACAGCGAGGAATAGCTCCCGAGTTTT SEQ ID NO:195 GCGGCCTCCAGGTGGTGGATCCAATTTTTCATTAGGTTTTGATGAACCAACAGAACAACCTG TGAGGAAGAACAAAATGCCCTCTAATATCTTTGGGACACCTCAAGAAAATCAAGCTTCTTGG GCCAAGTCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCA GAGAAGGAACTCCTCTCAAGCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATA TTCATGAAAATGTGGACACAGACTTGCCAGGCACCCTGGGGCAGAGTGAAGAGAAGCCCGTG CCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCC TGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTACTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTCGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTATTCTTTCCCTTTTGAAGACCAGGTTTCTCTCTGTCCTTGACTCTGGGCTCTGTGGG CCATTGGCATGCAGTTGTCTCCTAGTACGTAGCATGGGCGGGAAACGCTTTGTGACCCCTTA CGTACTCCGCTTCCAAGAACGACATCATGGGGTCGCAGATTGTCGTAGAGGATCTTTGGCTA CCTGCCGCGTTCTTCACCGCCTTTTAACTGTGTGGTTATCCCAAGCCCTCCACTTGGACAGA ACCATTAACCATGCTCCACAGCGCACCGTCACTTGCAGGCCCAACCCCCAGGGGGGTCTTCC GAGAGACCTTTTGGTGTGCCTATTTGCCCAGGGCGTTGTCAACCCCCG (CloneID 3445695) GCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTCGCCCCGGCCCCTA SEQ ID NO:196 GTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTCCTTTGGAAGAACAGGTTTCTCTCTGTCCTTGACTCTGGGGTCTGTGCGC CATGGCATGAGTGTTTTCTAGTACTAGATTGGCGGGAAAGCTTTGTGACACTTAGTACTGTG TTTTAAGAAGAAATAATTGGGTCCCAGATGTGTTAGAGGATCTTTGGTACTGAGGTTTTTAA CACTTTACTTGGGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACAGGCACCGTT CCTGCCAGGCCCCAACCCACACGGAGTCTCTCCGCAGAGCCTTCTTGGTGTTGCCCTAACTT CCCAGTGGCCTTGGCTCAGAGCCTCCTCCTGTGACCTGTGAACAATGAAGAGGCCTGTGCCT CTGCCTTGCCGCTGCAGGCACAGAACTGCCTTTACTTTTTAACCTTAAAAAGTAGCCGATAG TACAAGCTGGTTGGCTGTTGAAGCCAAGCCTGGGTCTCACGCCGAGTAAGGCTGCCTGTTCC CTGCACACTGGCGGGACCAAAAGCCGTGAACCAGGGGGCCATCCACTGTAAGCGGGTCTCCC GGAACGGGCCCCAAGGGTGTTGTTACACTACCCGCGGGGGTGCATAGCTGTGGCTGCCCTCA CGAAGCTCCTAACAGGTTTGCTCACCGGCGGGGCCTGAAAATC (CloneID 5519819) TCAGCAGGTGCCAAGTCTAGTGGTGGCAGGGAAGACTTGGAGTCATCTGGACTGCAGAGAAG SEQ ID NO:197 GAACTCCTCTGAACCAAGCTCCGGAGACTTCTTAGATCTGAAGGGAGAAGGTGATATTCATG AAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCT GCGCCTGTGCCCAGCCCGGTGCCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGG CAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACT TGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGCTG TCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGG CCATGGCATGAGTGTTTTCTAGTAGTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGT GTTTTTAAGAAGACATAATTTGGTTCCAGATGTGTTAGAGGATCTTTTGTACTGAGGTTTTT AACACTTTACCTTGGGTTTACCAAGCCTTCCACTGGACAGGACCATAAACAGGTCCACAGGC CCCCCGTTTCTTGCCCAGGCCCCAACCCACAGGGGAAGTCTCTTCCGCCACAAACCCTTCCT TTGGTCGCCCGCCCTTACCACCTGCCCCCGGCGGGGCTCTTTATGCTTTGGCGGAGCTCTCT CCTCTCCTTCATTCGAAGACATGCTGACCAACAACCACGGCCACACCAACGCCCCTCTCTAT CTTTCTCATTGCGCCCCTGCGCCCTGTATTGAGCGCGCCCTCAGAATTCGCGGGGCATACAG GGCGCGCTGTCAATCCCCGAAACTCCAATATCGGTCTCCCCCCCGCTTTATATTAGCGCGCC CCGTCGCTTGTAACGAGCCTAACTCAATTTTTTTTTCCCGCACTCACGCCCCGCTCTCGGTG TTACCAACCAACAGAACAGTCCTCCTCCTTCATAATATTCCCCACACTCCCCCTCGCCATCT TACTCTTTTATTTNCCCCGCGCGCGTGTTAAAAGCCGCAAAGGNNCCCCCACCGCACACACG TATATTGCCCGGATTTTAATCATGAATTTTCCGCACCGGGCAAGACCACCCCCAGCTGCCCC ATCGTGTCCCCCGCCGTNCTGCAGAATTCCTCANATCTGGGCCCTCCGCGATAGGTCACTCC ATCCTCAGGAGAAAACACCCTCTTGTCCCACGCCGTCCACTCTTAATACCGCCGTACCCTCA TGTCCCCTCCGCCACTTCTTTTTACCCCCTCNGCGCTGTAGTTTTGCGGCGCCCCGACTACA CTCACACCGATTATTTATTATCCCCCTTCANCCGACGCCGGNNGCCCCGAAAAAATGCCGCC CCGGATCGATAACAGCTCACCCCCGCCCCCGCCAGGATGCCCCGCCGCCAGCTAAAAGGCGC TCAACCA (CloneID 2989794) CACGAGCACTGATGCCCAAGAGTTAAATGGCCTCTAATATCTTTGGGACACCATGAAGAAAA SEQ ID NO:198 TCAAGACTTCTTGGGCCAAGTCAACAGGTGCCAAGTCTAGTGGTGGAAGGGAAGACTTGTGA GTCATCTGGACTGCAGAGAAGGAACTCCTCTGAAGCAAGCTCCGGAGACTTCTTAGATCTGA AGGGAGAAGGTGATATTCATGAAAATGTGAGACACAGACTTGCCAGTGCAGCCTGGCGCAGA GTGAAGAGAAGCCCTGTGCCTGCTGCTGCCTGTGCCCAGCCCTGGTGGACCCAGGCCCCAGT GCCATCCAGAAGAAATCCCCACTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG CTCTGACTGTCCTGAACTGCTAGTCAGATATCTAGTCTGTAACCTCCATGCTTGTGAACTGC ACAACTTGAGCCTGACTGTACATCTCTTGGAATTTGTTTCATTAAAAAAAAGCACTTATATG TACTGCTGTCTTTATTATTAATATACTTTGTGCAAGAACAGGTAAACACATCTGACACATTG ACCTCTGTGGACTCTGTGAGAGCCATAGGCATTGAGTTGTGAACTAGCTAGATACATGGCGA GGGAACAGCTTTGTGAACACTAAGAACTCAGATCATAACGACAAAATACATGGGTCCAGATG TGTAGAGGATCTAAGGAAATGAGGTATAAAACTAACTTGGTTTCCAAGCTCAATGGGCGACA (CloneID 1637898 in 3′ to 5′ orientation) AAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCAAGTTGTGCAGT SEQ ID NO:199 TCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACCAGGCTGGACTTGCCGCCAGGGGGATTTCTTCTGGATGGCACTGGGGCCG GGGCCACCGGCCTGGGCACAGGCGCAGCAGGCACGGCCTTCTCTTCACTCTGCCCCAGGCTG CCTGGCAAGTCTGTGTCCACATTTTCATCAATATCACCTTCTCCCTTCAGATCTAAGAAGTC TCCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCTTCCCTGC CACCACTAGACTTGGCACCTGCTGACTTGGCCCAAGAAGCTTGATTTTCTTCAGGTGTCCCA AAGATATTAGAGGCCATTTTGTTCTTCCTCACAGGTTGTTCTGTTGGTTCATCAAAACCTAA TGAAAAATTGGATCCACCACCTGGAGGCCGCAAAACTCGGGAGCTATTCCTGCTGTTGGGGT CGACTCCCTTGAAGGTGGT (CloneID 1132042 in 3′ to 5′ orientation) TTTTTTTAAAGTGCTTCTTTTTAATGAAACAAATCCAAGAGATGTACAGTCAGGCTCAAGTT SEQ ID NO:200 GTGCAGTTCACAAGCATGGAGGAAACAGACAGAACGACAGCGTTCAGGACAGTCAGAG CTAACCCAAGACGAGGCTGGACTTCCCGCCAGGGAGATTTCTTCTGGATGGCACTGGGGCCG GGGCACCGGGCTGGGCACAGGCGCACGAGGCACGGGCTTCTCTTCACTCTGCCCCACGCTGC CTGGCAAGTCTGTGTCCACATTTTCATGAATATCACCTTCTCCCTTCAGATCTAAGAAGTCT CCGGAGCTTGCTTCAGAGGAGTTCCTTCTCTGCAGTCCAGATGACTCCAAGTCT

[0054] In another set of preferred embodiments of the invention, the sequence, or a unique portion thereof, of the ESE-2/ELF5 sequences identified by the I.M.A.G.E. Consortium CloneIDs 1864302 and 4480123 as well as clusters C019657 and NM—001422 may be used. Similarly, sequences from the UniGene Homo sapiens cluster Hs.11713, may be used. ESE-2/ELF5 sequences are useful in discriminations between normal and ADH or DCIS or IDC breast cells based upon decreased expression in non-normal breast cells. Human ESE-2/ELF5 has been mapped to 11p13-p15.

[0055] ESE-2/ELF5 related sequences are as follows, with the assigned coding region (ending with a termination codon) underlined and preceded by the 5′ untranslated and/or non-coding region and followed by the 3′ untranslated and/or non-coding region. The 3′ untranslated and/or non-coding regions are presented as the complementary strand in the 3′ to 5′ direction for some of the sequences.

[0056] SEQ ID NOS:204-209 are found in the 3′ untranslated and/or non-coding regions of the disclosed ESE-2/ELF5 sequences. 5 (CloneID 4480123, ESE-2b/ELF5) CACAAGGCTACAGGTGTCTTTATTTCCACTGCACGCTGGTGCTGGGAGCGCCTGCCTTCTCT SEQ ID NO:201 TGCCTTGAAAGCCTCCTCTTTGGACCTAGCCACCGCTGCCCTCACGGTA ATGTTGGACTCGGTGACACACAGCACCTTCCTGCCTAATGCATCCTTCTGCGATCCCCTGAT GTCGTGGACTGATCTGTTCAGCAATGAAGAGTACTACCCTGCCTTTGAGCATCAGACAGCCT GTGACTCATACTGGACATCAGTCCACCCTGAATACTGGACTAAGCGCCATGTGTGGGAGTGG CTCCAGTTCTGCTGCGACCAGTACAAGTTGGACACCAATTGCATCTCCTTCTGCAACTTCAA CATCAGTGGCCTGCAGCTGTGCAGCATGACACAGGAGGAGTTCGTCGAGGCAGCTGGCCTCT GCGGCGAGTACCTGTACTTCATCCTCCAGAACATCCGCACACAAGGTTACTCCTTTTTTAAT GACGCTGAAGAAAGCAAGGCCACCATCAAAGACTATGCTGATTCCAACTGCTTCAAAACAAG TGGCATCAAAAGTCAAGACTGTCACAGTCATAGTAGAACAAGCCTCCAAAGTTCTCATCTAT GGGAATTTGTACGAGACCTGCTTCTATCTCCTGAAGAAAACTGTGGCATTCTGGAATGGGAA GATAGGGAACAAGGAATTTTTCGGGTGGTTAAATCGGAAGCCCTGGCAAAGATGTGGGGACA AAGGAAGAAAAATGACAGAATGACATATGAAAAGTTGAGCAGAGCCCTGAGATACTACTATA AAACAGGAATTTTGGAGCGGGTTGACCGAAGGTTAGTGTACAAATTTGGAAAAAATGCACAC GGGTGGCAGGAAGACAAGCTATGA TCTGCTCCAGGCATCAAGCTCATTTTATGGATTTCTGTCTTTTAAAACAATCAGATTGCAAT AGACATTCGAAAGGCTTCATTTTCTTCTCTTTTTTTTTTAACCTGCAAACATGCTGATAAAA TTTCTCCACATCTCAGCTTACATTTGGATTCAGAGTTGTTGTCTACGGAGGGTGAGAGCAGA AACTCTTAAGAAATCCTTTCTTCTCCCTAAGGGGATGAGGGGATGATCTTTTGTGGTGTCTT GATCAAACTTTATTTTCCTAGAGTTGTGGAATGACAACAGCCCATGCCATTGATGCTGATCA GAGAAAAACTATTCAATTCTGCCATTAGAGACACATCCAATGCTCCCATCCCAAAGGTTCAA AAGTTTTCAAATAACTGTGGCAGCTCACCAAAGGTGGGGGAAAGCATGATTAGTTTGCAGGT TATGGTAGGAGAGGGTGAGATATAAGACATACATACTTTAGATTTTAAATTATTAAAGTCAA AAATCCATAGAAAAGTATCCCTTTTTTTTTTTTTTGAGACGGGTTCTCACTATGTTGCCCAG GGCTGGTCTTGAACTCCTATGCTCAAGTGATCCTCCCACCTCGGCCTCCCAAAGTACTGTGA TTACAAGCGTGAGCCACGGCACCTGGGCAGAAAAGTATCTTAATTAATGAAAGAGCTAAGCC ATCAAGCTGGGACTTAATTGGATTTAACATAGGTTCACAGAAAGTTTCCTAACCAGAGCATC TTTTTGACCACTCAGCAAAACTTCCACAGACATCCTTCTGGACTTAAACACTTAACATTAAC CACATTATTAATTGTTGCTGAGTTTATTCCCCCTTCTAACTGATGGCTGGCATCTGATATGC AGAGTTAGTCAACAGACACTGGCATCAATTACAAAATCACTGCTGTTTCTGTGATTCAAGCT GTCAACACAATAAAATCGAAATTCATTGATTCCATCTCTGGTCCAGATGTTAAACGTTTATA AAACCGGAAATGTCCTAACAACTCTGTAATGGCAAATTAAATTGTGTGTCTTTTTTGTTTTG TCTTTCTACCTGATGTGTATTCAAGTGCTATAACACGTATTTCCTTGACAAAAATAGTGACA GTGAATTCACACTAATAAATGTTCATAGGTTAAAGTCTGCACTGACATTTTCTCATCAATCA CTGGTATGTAAGTTATCAGTGACTGACAGCTAGGTGGACTGCCCCTAGGACTTCTGTTTCAC CAGAGCAGGAATCAAGTGGTGAGGCACTGAATCGCTGTACAGGCTGAAGACCTCCTTATTAG AGTTGAACTTCAAAGTAACTTGTTTTAAAAAATGTGAATTACTGTAAAATAATCTATTTTGG ATTCATGTGTTTTCCAGGTGGATATAGTTTGTAAACAATGTGAATAAAGTATTTAACATGTA AAAAAAAAAAAAAA (ESE-2a) GGCTGAGTGGTTTGCTCCTTCCCCTCTCTCTGGGAGGCTGAGCAGGGGTGCCTGGGTTGCTC SEQ ID NO:202 AGGCCATGGGAGCCACACCTGTTATTGCTGCCTCTGATTTGTGTGACACTGAGAAGCCCACA GGCCTGTCCCTCCAACTCGGTGGACCCTCTCTGTGTGCATTTGGTGTGTGAGCCAGCTCTGA GAAGGGTTCAGAAGCCACTGGAGGCATCTGGGGACCTCAGCTTCC ATGCCATCTCTGCCTCACTCCCACAGGGTAATGTTGGACTCGGTGACACACAGCACCTTCCT GCCTAATGCATCCTTCTGCGATCCCCTGATGTCGTGGACTGATCTGTTCAGCAATGAAGAGT ACTACCCTGCCTTTGAGCATCAGACAGCCTGTGACTCATACTGGACATCAGTCCACCCTGAA TACTGGACTAAGCGCCATGTGTGGGAGTGGCTCCAGTTCTGCTGCGACCAGTACAAGTTGGA CACCAATTGCATCTCCTTCTGCAACTTCAACATCAGTGGCCTGCAGCTGTGCAGCATGACAC AGGAGGAGTTCGTCGAGGCAGCTGGCCTCTGCGGCGAGTACCTGTACTTCATCCTCCAGAAC ATCCGCACACAAGGTTACTCCTTTTTTAATGACGCTGAAGAAAGCAAGGCCACCATCAAAGA CTATGCTGATTCCAACTGCTTGAAAACAAGTGGCATCAAAAGTCAAGACTGTCACAGTCATA GTAGAACAAGCCTCCAAAGTTCTCATCTATGGGAATTTGTACGAGACCTGCTTCTATCTCCT GAAGAAAACTGTGGCATTCTGGAATGGGAAGATAGGGAACAAGGAATTTTTCGGGTGGTTAA ATCGGAAGCCCTGGCAAAGATGTGGGGACAAAGGAAGAAAAATGACAGAATGACGTATGAAA AGTTGAGCAGAGCCCTGAGATACTACTATAAAACAGGAATTTTGGAGCGGGTTGACCGAAGG TTAATGTACAAATTTGGAAAAAATGCACACGGGTGGCAGGAAGACAAGCTATGA TCTGCTCCAGGCATCAAGCTCATTTTATGGATTTCTGTCTTTTAAAACAATCAGATTGCAAT AGACATTCGAAAGGCTTCATTTTCTTCTCTTTTTTTTTAACCTGCAAACATGCTGATAAAAT TTCTCCACATCTCAGCTTACATTTGGATTCAGAGTTGTTGTCTACGGAGGGTGAGAGCAGAA ACTCTTAAGAAATCCTTTCTTCTCCCTAAGGGGATGAGGGGATGATCTTTTGTGGTGTCTTG ATCAAACTTTATTTTCCTAGAGTTGTGGAATGACAACAGCCCATGCCATTGATGCTGATCAG AGAAAAACTATTCAATTCTGCCATTAGAGACACATCCAATGCTCCCATCCCAAAGGTTCAAA AGTTTTCAAATAACTGTGGCAGCTCACCAAAGGTGGGGGAAAGCATGATTAGTTTGCAGGTT ATGGTAGGAGAGGGTGAGATATAAGACATACATACTTTAGATTTTAAATTATTAAAGTCAAA AATCCATAGAAAAGTATCCCTTTTTTTTTTGAGACGGGTTCTCACTATGTTGCCCAGGGCTG GTCTTGAACTCCTATGCTCAAGTGATCCTCCCACCTCGGCCTCCCAAAGTACTGTGATTACA AGCGTGAGCCACGGCACCTGGGCAGAAAAGTATCTTAATTAATGAAAGAGCTAAGCCATCAA GCTGGGACTTAATTGGATTTAACATAGGTTCACAGAAAGTTTCCTAACCAGAGCATCTTTTT GACCACTCAGCAAAACTTCCACAGACATCCTTCTGGACTTAAACACTTAACATTAACCACAT TATTAATTGTTGCTGAGTTTATTCCCCCTTCTAACTGATGGCTGGCATCTGATATGCAGAGT TAGTCAACAGACACTGGCATCAATTACAAAATCACTGCTGTTTCTGTGATTCAAGCTGTCAA CACAATAAAATCGAAATTCATTGATTCCATCTCTGGTCCAGATGTTAAACGTTTATAAAACC GGAAATGTCCTAACAACTCTGTAATGGCAAATTAAATTGTGTGTCTTTTTTGTTTTGTCTTT CTACCTGATGTGTATTCAAGCGCTATAACACGTATTTCCTTGACAAAAATAGTGACAGTGAA TTCACACTAATAAATGTTCATAGGTTAAAGTCTGCACTGACATTTTCTCATCAATCACTGGT ATGTAAGTTATCAGTGACTGACAGCTAGGTGGACTGCCCCTAGGACTTCTGTTTCACCAGAG CAGGAATCAAGTGGTGAGGCACTGAATCGCTGTACAGGCTGAAGACCTCCTTATTAGAGTTG AACTTCAAAGTAACTTGTTTTAAAAAATGTGAATTACTGTAAAATAATCTATTTTGGATTCA TGTGTTTTCCAGGTGGATATAGTTTGTAAACAATGTGAATAAAGTATTTAACATGCGAA (alternative ELF5 encoding sequence) CAAGGCTACAGGTGTCTTTATTTCCACTGCACGCTGGTGCTGGGAGCGCCTGCCTTCTCTTG SEQ ID NO:203 CCTTGAAAGCCTCCTCTTTGGACCTAGCCACCGCTGCCCTCACGGTA ATGTTGGACTCGGTGACACACAGCACCTTCCTGCCTAATGCATCCTTCTGCGATCCCCTGAT GTCGTGGACTGATCTGTTCAGCAATGAAGAGTACTACCCTGCCTTTGAGCATCAGACAGCCT GTGACTCATACTGGACATCAGTCCACCCTGAATACTGGACTAAGCGCCATGTGTGGGAGTGG CTCCAGTTCTGCTGCGACCAGTACAAGTTGGACACCAATTGCATCTCCTTCTGCAACTTCAA CATCAGTGGCCTGCAGCTGTGCAGCATGACACAGGAGGAGTTCGTCGAGGCAGCTGGCCTCT GCGGCGAGTACCTGTACTTCATCCTCCAGAACATCCGCACACAAGGTTACTCCTTTTTTAAT GACGCTGAAGAAAGCAAGGCCACCATCAAAGACTATGCTGATTCCAACTGCTTGAAAACAAG TGGCATCAAAAGTCAAGACTGTCACAGTCATAGTAGAACAAGCCTCCAAAGTTCTCATCTAT GGGAATTTGTACGAGACCTGCTTCTATCTCCTGAAGAAAACTGTGGCATTCTGGAATGGGAA GATAGGGAACAAGGAATTTTTCGGGTGGTTAAATCGGAAGCCCTGGCAAAGATGTGGGGACA AAGGAAGAAAAATGACAGAATGACATATGAAAAGTTGAGCAGAGCCCTGAGATACTACTATA AAACAGGAATTTTGGAGCGGGTTGACCGAAGGTTAGTGTACAAATTTGGAAAAAATGCACAC GGGTGGCAGGAAGACAAGCTATGA TCTGCTCCAGGCATCAAGCTCATTTTATGGATTTCTGTCTTTTAAAACAATCAGATTGCAAT AGACATTCGAAAGGCTTCATTTTCTTCTCTTTTTTTTTAACCTGCAAACATGCTGATAAAAT TTCTCCACATCTCAGCTTACATTTGGATTCAGAGTTGTTGTCTACGGAGGGTGAGAGCAGAA ACTCTTAAGAAATCCTTTCTTCTCCCTAAGGGGATGAGGGGATGATCTTTTGTGGTGTCTTG ATCAAACTTTATTTTCCTAGAGTTGTGGAATGACAACAGCCCATGCCATTGATGCTGATCAG AGAAAAACTATTCAATTCTGCCATTAGAGACACATCCAATGCTCCCATCCCAAAGGTTCAAA AGTTTTCAAATAACTGTGGCAGCTCACCAAAGGTGGGGGAAAGCATGATTAGTTTGCAGGTT ATGGTAGGAGAGGGTGAGATATAAGACATACATACTTTAGATTTTAAATTATTAAAGTCAAA AATCCATAGAAAAGTATCCCTTTTTTTTTTGAGACGGGTTCTCACTATGTTGCCCAGGGCTG GTCTTGAACTCCTATGCTCAAGTGATCCTCCCACCTCGGCCTCCCAAAGTACTGTGATTACA AGCGTGAGCCACGGCACCTGGGCAGAAAAGTATCTTAATTAATGAAAGAGCTAAGCCATCAA GCTGGGACTTAATTGGATTTAACATAGGTTCACAGAAAGTTTCCTAACCAGAGCATCTTTTT GACCACTCAGCAAAACTTCCACAGACATCCTTCTGGACTTAAACACTTAACATTAACCACAT TATTAATTGTTGCTGAGTTTATTCCCCCTTCTAACTGATGGCTGGCATCTGATATGCAGAGT TAGTCAACAGACACTGGCATCAATTACAAAATCACTGCTGTTTCTGTGATTCAAGCTGTCAA CACAATAAAATCGAAATTCATTGATTCCATCTCTGGTCCAGATGTTAAACGTTTATAAAACC GGAAATGTCCTAACAACTCTGTAATGGCA (CloneID 377520) CAGACACTGGCATCAATTACAAAATCACTGCTGTTTCTGTGATTCAAGCTGTCAACACAATA SEQ ID NO:204 AAATCGAAATTCATTGATTCCATCTCTGGTCCAGATGTTAAACGTTTATAAAACCGGAAATG TCCTAACAACTCTGTAATGGCAAATTAAATTGTGTGTCTTTTTTGTTTTGTCTTTCTACCTG ATGTGTATTCAAGCGCTATAACACGTATTTCCTTGACAAAAATAGTGACAGTGAATTCACAC TAATAAATGTTCATAAGGTTAAAGTCTGCACTGACATTTTCTCATCAATCACTGGTATGTAA GTTATCAGTGACNGACAGCTAAGGTGNGACTGG (CloneID 377520 in 3′ to 5′ orientation) GAACATGTTAAATACTTTATTCACATTGTTTACAAACTATATCCACCTGGAAAACACATGAA SEQ ID NO:205 TCCAAAATAGATTATTTTACAGTAATTCACATTTTTTAAAACAAGTTACTTTGAAGTTCAAC TCTAATAAGGAGGTCTTCAGCCTGTACAGCGATTCAGTGCCTCACCACTTGATTCCTGCTCT GGTGAAACAGAAGTCCTAGGGGCAGTCCACCTAG (CloneID 81671) TGATTCAAGCTGTCAACACAATAAAATCGAAATTCATTGATTCCATCTCTGGTCCAGATGTT SEQ ID NO:206 AAACGTTTATAAAACCGGAAATGTCCTAACAACTCTGTAATGGCAAATTAAATTGTGTGTCT TTTTTGTTTTGTCTTTCTACCTGATGTGTATTCAAGCGCTATAACAC (CloneID 81671 in 3′ to 5′ orientation) GCGGTGAAATACTTTATTCACATTGTTTACAAACTATATCCACCTGGAAAACACATGAATCA SEQ ID NO:207 AAATAGATTATTTTACAGTAATNACATTTTTTAAAACAAGTTACTTTGAAGTCAACTCTAAT AAGGAGGTCTTCAGCCTGTACAGCGATTCAGTGCCTCACCACTTGATTCCTGCTCTGGTGAA CAGAAGTCCTAGGGGCAATCCACCTAGCTGTCAGTCACTGATAACTTACATACCAGTGATTG ATGAGAAAATGTCAGTGCAGACTTTAACCTATGAACATTTATTAGTGTGAATTCACTGTCAC TATTTTTGTCAAGGAAATACGTGTTATAGCGCTTGAATACACATCAGGTAGAAAGACAAANC AAAAAAGNCACACAATTTAATTTGCCATTACAGAGTTGTTAGGGCCATTTCCGGTTTTATAA ACGTTTACATCTGGGCCNGAGATGGGATCAATGAATTTCGNTTTTATTGTGTTGACCGCTTG NATCACCTCGTGCCGATTTCCTGCGGCCCGGGGNTCCCCTAGTT (CloneID 2956497 in 3′ to 5′ orientation) AGACGGGTTCTCACTATGTTGCCCAGGGCTGGTCTTGAACTCCTATGCTCAAGTGATCCTCC SEQ ID NO:208 CACCTCGGCCTCCCAAAGTACTGTGATTACAAGCGTGAGCCACGGCACCTGGGCAGAAAAGT ATCTTAATTAATGAAAGAGCTAAGCCATCAAGCTGGGACTTAATTGGATTTAACATAGGTTC ACAGAAAGTTTCCTAACCAGAGCATCTTTTTGACCACTCAGCAAAACTTCCACAGACATCCT TCTGGACTTAAACACTTAACATTAACCACATTATTAATTGTTGCTGAGTTTATTCCCCCTTC TAACTGATGGCTGGCATCTGATATGCAGAGTTAGTCAACAGACACTGGCATCAATTACAAAA TCACTGCTGTTTCTGTGATTCAAGCTGTCAACACAATAAAATCGAAATTCATTGATTCCATC TCTGGTCCAGATGTTAAACGTTTATAAAACCGG (CloneID 1864302 in 3′ to 5′ orientation) TGAACATGTTAAATACTTTATTCACATTGTTTACAAACTATATCCACCTGGAAAACACATGA SEQ ID NO:209 ATCCAAAATAGATTATTTTACAGTAATTCACATTTTTTAAAACAAGTTACTTTGAAGTTCAA CTCTAATAAGGAGGTCTTCAGCCTGTACAGCGATTCAGTGCCTCACCACTTGATTCCTGCTC TGGTGAAACAGAAGTCCTAGGGGCAGTCCACCTAGCTGTCAGTCACTGATAACTTACATACC AGTGATTGATGAGAAAATGTCAGTGCAGACTTTAACCTATGAACATTTATTAGTGTGAATTC ACTGTCACTATTTTTGTCAAGGAAATACGTGTTATAGCACTTGAATACACATCAGGTAGAAA GACAAAACAAAAAAGACACACAATTTAATT (ESE-2 promoter 1, positions 1-1046, and 5′ untranslated region of ESE-2b, positions 1047 to >1106) TTCAATCCCACTTCCTCCTTTTGCCACTGGGGAAAAATGAAGCCCAGAGAAGTCCAGGTTAC SEQ ID NO:210 CCAGCCAAGATAGGGGTCTAGGCAGTCACCTATCTTCCTTCAACAATTTTTCCATGATGACA CCCCGAATCCTCTCACGAACTGCCTTTTGTTTCTGCAGACTATATGCGTATTTGTATTTGTG TGTTTGTAACCATGCCCGGTGATCCCAAGAAAACATAACAAACCAGTCCTTGCTTTCGCTTT AAAGCTTGGAGTCTGCCATTTGAATACAACATCTCGGCTGCCCAAGATGGCTAGAAGCAGAA TGCAAAAAGGCACAAGGGTTATAAATACCTGTCTCATAGATGACCCGGGACACTTGTGCTTT GCAGCCTAAATTAGGCAGAGTTTCTGTTGTCACGGAGAAGTACTAAAAAGCGGGCAGTTCTC AGCGAGACACCTTGAGAGGCTGGCATCCACATGAGGAGAGGCCCCATCACTTACATTACACT CATGAAGCCCAAGAGATGTTAAGCTACATTTTTCTAGGTAGCACAGCTAGGAAATGATGGAC ACTGAATTTTGAATCTAAAGGCAACTAGCTGCAAAACCTGAGGTCTCAACACTGGGCCTATA ATGCTCTTCCTTCTCACCACATGGGAAAAACGGAGAAAGACATGATCTTACAAAAGCACTGG GCTCAGCCAGCCTGGGAGAGAGGCAGCGCAAACCGGCACCAGGGTGGAATCTCTGTGTTTCC CCTCCAGCTTGCACAGAGGAAAATTCCTCACCAAACGCACGATCCCCGCACAGCTTCCCAGG GACAAGAATTTTCTGCTTGTTTACTGAGTCCCCTGGGCTGGGAGTGGGGGGTTTGCAGGGCA GGGGTGAGCTGCGCACAAAAGCAGGATAAAGGTAAACTTTCTGCATATGAGAACCATTTCCC CCCCTCCATAGGAGCCGTGTCACACTGTATGTCACCGTCATCAAAGGGGCTGTGCGTAAACC TGAAAAACCAAACGGACCTGTCTGTAGGTGTCACTTATATCACAAGGTACAGGTGTCTTTAT TTCCACTGCACGCTGGTGCTGGGAGCGCCTGCCTTCTCTTGCCTTGAAAGCC (ESE-2 promoter 2, positions 1-1879, and 5′ untranslated region of ESE-2a, positions 1080 to >1975) GTAAGCGCCTTTTCTTTGCTTTTTTGGATGAATCGTAAGGGGTGTCAGGGCTCAGAGGCTCG SEQ ID NO:211 GCCTGGGGCCTGGGTCTGCTCGTCCATCTCCAGCTCCAGGGCCGGCACCTGCGCTGGGTGCA GTCCCAGGGCCTCCGGGAGCTGTTTGACACGGATGTGACGGCTTGCCTCAGAGAGACCTGCT TGCCTCCGCAGGCCGTGTGGCCACCAGCCCTCCTCACAGCCACCACTCCCTCTGGATCCCTT AGCTGAACCAAGGGGAATTAAGAGAACGCGCCCAGGCGCTCAGTTCTCTATCCTCCCTAAAG CTTCTTTAGGAAGGGAAGCTGGATTTTACTCAGAAAAATATTCAGCTTCAAGGAAAGCCCCC CACCTACCCTTCTCCCCTGACTGAATTCCTTTCCCCACCGGCCTGCCCACTGTCCCCCACCC CCTCGATACAAAGAACTCCCTTATTATAGTTTGGGGCATTTTCAGGAATTTGTACAAAACAG TTTTAAAAGAAACCCATTTGCCCTCTGACATCTTCCCCAGAAGAGAATGCTTCCAGAAAAGC AATGGTTAGCGTTTTTCCACTGTGTTCTCAGGCCTTGTCAGACTCTGCAGTGTGTGGGGTTT CTGTGGGGTTGCCCCCTGCTGACAGCGACAGGTAGCACAAGCTCCCTCCTCAGGCTGAAGCC GGGCCTGCGTGTGGATGCCTTTTGTACGCCCGAAAGTGTGTCAGACATCACTAGGTGCAATC GCTTCATGTTACAGATGAGGAAACTGAGGCCAGAAAGGCTAGATGACTTAGGGAGGCAGCTC TGTGGTTCAGTCTAGTCCAGAGACCCAGGGAAAGGGGTGGTTTGCCCATCCGAGTGAACGGC TTGATTCTGTTGTCTTCGTGTTCTCTGCAATACTGTTTTTCATAATCTAAGGTATTCTCGGG CCGGAGTTTTCAGTTTGGTCATCTCCCTTTTTCAGAAGTCACCAGAGTGGCAAATTTTTAGA TTCATTGTTGATGGCTGATTTTTCCCTCTAAAACAGGATTGAATATATGTATTATGCCCCGT CCTTTGCATATATCGGATTGCATGATTTAAAAAAAAAAAAATCCCCATTTTAGAGATGAGGG AAACCGTAGTTCGAAGAGGGGCATGAATATTTATATACCACATCTATATGAAAAAAAGCTTA AGAATTTCAGCAGTCTGGGTAGTAAGAAATGTGCCCCACGTTCGCAGCAGCAGAGGTAGGAT TTAACCCCTGATATATGTAATCCAAAACTGGTAAGCTTTGCATCGAAGCCTACAGCAAACTA CATGGCATACCTTTTTGGATCTTCGCTGCACCTTCAGAAAAACAGCTACAAACAAACAAACA CGCAAACTCCCTAAGCGAGCTAAAGAAAAATGAGGAATCACTTGACAAGAGGTCAGCAAATT GGTTCTCACAGTTGCTAGGGTTCCTCTCAGAAGAACAAACCCTCAAGCACCCACCCTCAATC TTTCTTTAGCAGTAAGTGTTGAAATACTCCACTGGGTTCTCCTCAGTGGGCCCCTTCTTAGG GAGGTCCAAGGGCTGGGAAATTGACCCTCCCTTGCTCACAAGTCTTGGGACGGAGTGGACAT TTGGGTATCACTGAGGCTTTAAGGAAGGAAAACCGATTTTCTTCCCAATGATACCACTCAGA GGGTGGGGTTGAGGAAGCCCAATCTTGGCCACTTTTTTCTATATTTTGCACCCTATGGCCTA GTTCTGCCCAGTGATGATTCGGCCCGTAAACAGCCAATGTGTAGATGCTTAATTGGGCCAAT TTTTGGTCACATGCCCAGAGTGAAGTTGATGATCACCACCAGAGTCAGGAAGGAATTTTCCT CCTCTGGCAAACTGGCCAAGGCTGAGTGGTTTGCTCCTTCCCCTCTCTCTGGGAGGCTGAGC AGGGGTGCCGGGTTGCTCAGGCCATGGGAGCCACACCTGTTATTGCTGCCTCT

[0057] All sequences are provided using conventional representations of a DNA strand starting from the 5′ phosphate linked end to the 3′ hydroxyl linked end. The above assignment of coding regions is generally by comparison to available consensus sequence(s) and therefore may contain inconsistencies. These have no effect on the practice of the invention because the invention can be practiced by use of shorter segments (or combinations thereof) of sequences unique to each of the three sets described above and not affected by inconsistencies. As a non-limiting example, a segment of CRIP1 composed of a 3′ untranslated region sequence and a sequence from the 3′ end of the coding region may be used as a probe for the detection of CRIP1 expression without being affected by the presence of any inconsistency in the representations of the coding regions provided above. Similarly, the use of an antibody which specifically recognizes CRIP1 protein to detect its expression would not be affected by the presence of any inconsistency in the representation of the coding regions provided above.

[0058] As will be appreciated by those skilled in the art, some of the above sequences include 3′ poly A (or poly T on the complementary strand) stretches that do not contribute to the uniqueness of the disclosed sequences. The invention may thus be practiced with sequences lacking the 3′ poly A (or poly T) stretches. The uniqueness of the disclosed sequences refers to the portions or entireties of the sequences which are found only in CRIP1, HN1, and ESE-2/ELF5 nucleic acids. Preferred unique sequences for the practice of the invention are those which contribute to the consensus sequences for each of the three sets. These preferred unique sequences are of the lengths of polynucleotides of the invention as discussed herein.

[0059] To determine the (increased or decreased) expression levels of the above described sequences in the practice of the present invention, any method known in the art may be utilized. In one preferred embodiment of the invention, expression based on detection of RNA which hybridizes to polynucleotides containing the above described sequences is used. This is readily performed by any RNA detection or amplification+detection method known or recognized as equivalent in the art such as, but not limited to, reverse transcription-PCR (optionally real-time PCR), the methods disclosed in U.S. patent application Ser. No. 10/062,857 entitled “Nucleic Acid Amplification” filed on Oct. 25, 2001 as well as U.S. Provisional Patent Application Nos. 60/298,847 (filed Jun. 15, 2001) and 60/257,801 (filed Dec. 22, 2000), the methods disclosed in U.S. Pat. No. 6,291,170, and quantitative PCR. Methods to identify increased RNA stability (resulting in an observation of increased expression) or decreased RNA stability (resulting in an observation of decreased expression) may also be used. These methods include the detection of sequences that increase or decrease the stability of mRNAs containing the CRIP1, HN1, and ESE-2/ELF5 sequences disclosed herein. These methods also include the detection of increased mRNA degradation.

[0060] In particularly preferred embodiments of the invention, polynucleotides having sequences present in the 3′ untranslated and/or non-coding regions of the above disclosed sequences are used to detect expression or non-expression of CRIP1, HN1, and ESE-2/ELF5 sequences in breast cells in the practice of the invention. Such polynucleotides may optionally contain sequences found in the 3′ portions of the coding regions of the above disclosed sequences. Polynucleotides containing a combination of sequences from the coding and 3′ non-coding regions preferably have the sequences arranged contiguously, with no intervening heterologous sequence(s).

[0061] Alternatively, the invention may be practiced with polynucleotides having sequences present in the 5′ untranslated and/or non-coding regions of the above CRIP1, HN1, and ESE-2/ELF5 sequences in breast cells to detect their levels of expression. Such polynucleotides may optionally contain sequences found in the 5′ portions of the coding regions. Polynucleotides containing a combination of sequences from the coding and 5′ non-coding regions preferably have the sequences arranged contiguously, with no intervening heterologous sequence(s).

[0062] Preferred polynucleotides contain sequences from 3′ or 5′ untranslated and/or non-coding regions of at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, at least about 32, at least about 34, at least about 36, at least about 38, at least about 40, at least about 42, at least about 44, or at least about 46 consecutive nucleotides. The term “about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Even more preferred are polynucleotides containing sequences of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides. The term “about” as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value.

[0063] Sequences from the 3′ or 5′ end of the above described coding regions as found in polynucleotides of the invention are of the same lengths as those described above, except that they would naturally be limited by the length of the coding region. The 3′ end of a coding region may include sequences up to the 3′ half of the coding region. Conversely, the 5′ end of a coding region may include sequences up the 5′ half of the coding region. Of course the above described sequences, or the coding regions and polynucleotides containing portions thereof, may be used in their entireties.

[0064] Polynucleotides combining the sequences from a 3′ untranslated and/or non-coding region and the associated 3′ end of the coding region are preferably at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides.

[0065] In another embodiment of the invention, polynucleotides containing deletions of nucleotides from the 5′ and/or 3′ end of the above disclosed sequences may be used. The deletions are preferably of 1-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-125, 125-150, 150-175, or 175-200 nucleotides from the 5′ and/or 3′ end, although the extent of the deletions would naturally be limited by the length of the disclosed sequences and the need to be able to use the polynucleotides for the detection of expression levels.

[0066] In yet another embodiment of the invention, polynucleotides containing portions of the above disclosed sequences including the 3′ end may be used in the practice of the invention. Such polynucleotides would contain at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides from the 3′ end of the disclosed sequences.

[0067] The invention thus also includes polynucleotides used to detect CRIP1, HN1, and ESE-2/ELF5 expression in breast cells. The polynucleotides may comprise a shorter polynucleotide consisting of sequences found in the above provided SEQ ID NOS in combination with heterologous sequences not naturally found in combination with CRIP1, HN1, and ESE-2/ELF5 sequences. As a non-limiting example, a polynucleotide of the invention may comprise a polynucleotide consisting of the sequence of SEQ ID NO: 29, with a deletion of one or more nucleotides from the 5′ and/or 3′ end, in combination with one or more non-HN1 sequences.

[0068] Other polynucleotides for use in the practice of the invention include those that have sufficient homology to those described above to detect expression by use of hybridization techniques. Such polynucleotides preferably have about or 95%, about or 96%, about or 97%, about or 98%, or about or 99% identity with CRIP1, HN1, or ESE-2/ELF5 sequences as described herein. Identity is determined using the BLAST algorithm, as described above. The other polynucleotides for use in the practice of the invention may also be described on the basis of the ability to hybridize to polynucleotides of the invention under stringent conditions of about 30% v/v to about 50% formamide and from about 0.01M to about 0.15M salt for hybridization and from about 0.01M to about 0.15M salt for wash conditions at about 55 to about 65° C. or higher, or conditions equivalent thereto.

[0069] In a further embodiment of the invention, a population of single stranded nucleic acid molecules comprising one or both strands of a human CRIP1 or HN1 sequence is provided as a probe such that at least a portion of said population may be hybridized to one or both strands of a nucleic acid molecule quantitatively amplified from RNA of a non-normal or abnormal breast cell. The population may be only the antisense strand of a human CRIP1 or HN1 sequence such that a sense strand of a molecule from, or amplified from, a non-normal or abnormal breast cell may be hybridized to a portion of said population. The population preferably comprises a sufficiently excess amount of said one or both strands of a human CRIP1 or HN1 sequence in comparison to the amount of expressed (or amplified) nucleic acid molecules containing a complementary CRIP1 or HN1 sequence from a normal breast cell. This condition of excess permits the increased amount of nucleic acid expression in a non-normal or abnormal cell to be readily detectable as an increase.

[0070] Alternatively, the population of single stranded molecules is equal to or in excess of all of one or both strands of the nucleic acid molecules amplified from a non-normal or abnormal breast cell such that the population is sufficient to hybridize to all of one or both strands. Preferred non-normal cells are ADH, DCIS, or IDC cells. The single stranded molecules may of course be the denatured form of any CRIP1 and/or HN1 sequence containing double stranded nucleic acid molecule or polynucleotide as described herein.

[0071] The population may also be described as being hybridized to CRIP1 or HN1 sequence containing nucleic acid molecules at a level of at least twice as much as that by nucleic acid molecules of a normal breast cell. As in the embodiments described above, the nucleic acid molecules may be those quantitatively amplified from a breast cell such that they reflect the amount of expression in said cell.

[0072] The population is preferably immobilized on a solid support, optionally in the form of a location on a microarray. A portion of the population is preferably hybridized to nucleic acid molecules quantitatively amplified from a non-normal or abnormal breast cell by real time PCR. The real time PCR may be practiced by use of amplified RNA from a breast cancer cell, as long as the amplification used was quantitative with respect to CRIP1 and/or HN1 containing sequences.

[0073] In another embodiment of the invention, expression based on detection of DNA status may be used. Detection of the ESE-2/ELF5 DNA as methylated, deleted or otherwise inactivated, may be used as an indication of decreased expression as found in non-normal breast cells. This may be readily performed by PCR based methods known in the art. The status of the promoter regions (SEQ ID NOS: 210 and 211) of the ESE-2/ELF5 may also be assayed as an indication of decreased expression of ESE-2/ELF5 sequences. A non-limiting example is the methylation status of sequences found in the promoter region.

[0074] Conversely, detection of the DNA of a sequence as amplified may be used for as an indication of increased expression as found in non-normal breast cells. This may be readily performed by PCR based, fluorescent in situ hybridization (FISH) and chromosome in situ hybridization (CISH) methods known in the art.

[0075] A preferred embodiment using a nucleic acid based assay to determine expression is by immobilization of one or more of the sequences identified herein on a solid support, including, but not limited to, a solid substrate as an array or to beads or bead based technology as known in the art. Alternatively, solution based expression assays known in the art may also be used. The immobilized sequence(s) may be in the form of polynucleotides as described herein such that the polynucleotide would be capable of hybridizing to a DNA or RNA corresponding to the sequence(s).

[0076] The immobilized polynucleotide(s) may be used to determine the state of nucleic acid samples prepared from sample breast cell(s) for which the pre-cancer or cancer status is not known or for confirmation of a status that is already assigned to the sample breast cell(s). Without limiting the invention, such a cell may be from a patient suspected of being afflicted with, or at risk of developing, breast cancer. The immobilized polynucleotide(s) need only be sufficient to specifically hybridize to the corresponding nucleic acid molecules derived from the sample.

[0077] In embodiments where only one or a few sequences are to be analyzed, the nucleic acid derived from the sample breast cancer cell(s) may be preferentially amplified by use of appropriate primers such that only the sequences to be analyzed are amplified to reduce contaminating background signals from other sequences present in the breast cell. Alternatively, and where the disclosed sequences are to be analyzed in combination with other sequences or where very few cells (or one cell) is used, the nucleic acid from the sample may be globally amplified before hybridization to the immobilized polynucleotides. Of course RNA, or the cDNA counterpart thereof may be directly labeled and used, without amplification, by methods known in the art.

[0078] Sequence expression based on detection of a presence, increase, or decrease in protein levels or activity may also be used. Detection may be performed by any immunohistochemistry (IHC) based, bodily fluid based (where a CRIP1, HN1, and/or ESE-2/ELF5 polypeptide is found in a bodily fluid, such as but not limited to blood), antibody (including autoantibodies against the protein where present) based, ex foliate cell (from the cancer) based, mass spectroscopy based, and image (including used of labeled ligand where available) based method known in the art and recognized as appropriate for the detection of the protein. Antibody and image based methods are additionally useful for the localization of tumors after determination of cancer by use of cells obtained by a non-invasive procedure (such as ductal lavage or fine needle aspiration), where the source of the cancerous cells is not known. A labeled antibody or ligand may be used to localize the carcinoma(s) within a patient.

[0079] Antibodies for use in such methods of detection include polyclonal antibodies, optionally isolated from naturally occurring sources where available, and monoclonal antibodies, including those prepared by use of CRIP1, HN1, and/or ESE-2/ELF5 polypeptides as antigens. Such antibodies, as well as fragments thereof (including but not limited to Fab fragments) function to detect or diagnose non-normal or cancerous breast cells by virtue of their ability to specifically bind CRIP1, HN1, or ESE-2/ELF5 polypeptides to the exclusion of other polypeptides to produce a detectable signal. Recombinant, synthetic, and hybrid antibodies with the same ability may also be used in the practice of the invention. Antibodies may be readily generated by immunization with a CRIP1, HN1, or ESE-2/ELF5 polypeptide, and polyclonal sera may also be used in the practice of the invention.

[0080] Antibody based detection methods are well known in the art and include sandwich and ELISA assays as well as Western blot and flow cytometry based assays as non-limiting examples. Samples for analysis in such methods include any that contain CRIP1, HN1, or ESE-2/ELF5 polypeptides. Non-limiting examples include those containing breast cells and cell contents as well as bodily fluids (including blood, serum, saliva, lymphatic fluid, as well as mucosal and other cellular secretions as non-limiting examples) that contain the polypeptides.

[0081] The above assay embodiments may be used in a number of different ways to identify or detect the presence of non-normal breast cells or breast cancer in a breast cancer cell sample from a patient. In some cases, this would reflect a secondary screen for the patient, who may have already undergone mammography or physical exam as a primary screen. If positive from the primary screen, the subsequent needle biopsy, ductal lavage, fine needle aspiration, or other analogous methods may provide the sample for use in the assay embodiments described herein. The present invention is particularly useful in combination with non-invasive protocols, such as ductal lavage or fine needle aspiration, to prepare a breast cell sample. The current analysis of ductal lavage samples is by cytological examination by a trained pathologist who classifies the samples in terms that are at least partly subjective: unsatisfactory (too few cells), benign (including fibrocystic change), atypical (or mild atypia), suspicious (or marked atypia), or malignant.

[0082] The present invention provides a more objective set of criteria, in the form of gene expression levels of discrete gene sequences, to discriminate (or delineate) between normal and non-normal breast cells.

[0083] In one embodiment of the invention, the isolation and analysis of a breast cancer cell sample may be performed as follows:

[0084] (1) Ductal lavage or other non-invasive procedure is performed on a patient to obtain a sample.

[0085] (2) Sample is prepared and coated onto a microscope slide. Note that ductal lavage results in clusters of cells that are cytologically examined as stated above.

[0086] (3) Pathologist or image analysis software scans the sample for the presence of atypical cells.

[0087] (4) If atypical cells are observed, those cells are harvested (e.g. by microdissection such as LCM).

[0088] (5) RNA is extracted from the harvested cells.

[0089] (6) RNA is assayed for the expression of CRIP1, HN1, and/or ESE-2/ELF5 sequences.

[0090] A specific example of the above method would be performing ductal lavage following a primary screen, observing and collecting non-normal cells (or cells suspected of being non-normal) for analysis. Alternatively, the sample may permit the collection of both normal and non-normal cells (or cells suspected of being non-normal) for analysis. The expression levels of CRIP1, HN1, and/or ESE-2/ELF5 sequences in each of these two populations may be compared to each other. This approach can be significantly more powerful than one using the non-normal cells only approach because it utilizes information from the normal cells and the differences between normal and non-normal cells to determine the status of the non-normal cells from the sample.

[0091] While many clinical settings focus on identification of the highest stage or grade of breast cancer, the detection of non-normal breast cells of any stage or grade is also important to identify with confidence the presence of, or susceptibility to, breast cancer as early as possible. With use of the present invention, skilled clinicians will be apprised of the presence of non-normal cells quickly and may begin treatment or additional testing based on such information.

[0092] The present invention may also be used with solid tissue biopsies. As a non-limiting example, a solid biopsy may be collected and prepared for visualization followed by determination of increased CRIP1 and/or HN1 expression to identify or diagnose the presence of non-normal cells. One preferred means is by use of in situ hybridization with polynucleotide or protein identifying probe(s) for assaying expression of said gene(s). An analogous method may be used to detect decreased expression of ESE-2/ELF5 sequences.

[0093] In an alternative method, the solid tissue biopsy may be used to extract molecules followed by analysis for expression of the disclosed sequence(s). This provides the possibility of leaving out the need for visualization and collection of only those cells suspected of being non-normal. This method may of course be modified such that only cells suspected of being non-normal are collected and used to extract molecules for analysis. This would require some form of selection as a prerequisite to gene expression analysis.

[0094] In a further modification of the above, both normal cells and cells suspected of being non-normal are collected and used to extract molecules for analysis of sequence expression. The approach, benefits and results are as described above using non-invasive sampling.

[0095] In a further alternative to all of the above, the sequence(s) identified herein may be used as part of a simple PCR or array based assay simply to determine the presence of non-normal cells in a sample from a non-invasive sampling procedure. If normal expression levels of the disclosed sequences are identified, no further examination may be necessary. If non-normal expression levels are detected, a more comprehensive analysis may follow.

[0096] The detection of sequence expression from samples may be by use of a single microarray able to assay expression of the disclosed sequences as well as other sequences, including sequences known not to vary in expression levels between normal and non-normal breast cells, for convenience and improved accuracy.

[0097] Other uses of the present invention include providing the ability to identify breast cancer cell samples as being non-normal for further research or study. This provides a particular advantage in many contexts requiring the identification of non-normal or cancerous cells based on objective genetic or molecular criteria rather than cytological observation.

[0098] The materials and methods of the present invention are ideally suited for preparation of kits produced in accordance with well known procedures. The invention thus provides kits comprising agents (like the polynucleotides and/or antibodies described herein as non-limiting examples) for the detection of expression of the disclosed sequences. Such kits, optionally comprising the agent with an identifying description or label or instructions relating to their use in the methods of the present invention, are provided. Such a kit may comprise containers, each with one or more of the various reagents (typically in concentrated form) utilized in the methods, including, for example, pre-fabricated microarrays, buffers, the appropriate nucleotide triphosphates (e.g., dATP, dCTP, dGTP and dTTP; or rATP, rCTP, rGTP and UTP), reverse transcriptase, DNA polymerase, RNA polymerase, and one or more primer complexes of the present invention (e.g., appropriate length poly(T) or random primers linked to a promoter reactive with the RNA polymerase). A set of instructions will also typically be included.

[0099] The methods provided by the present invention may also be automated in whole or in part. All aspects of the present invention may also be practiced such that they consist essentially of a subset, or subregion, of the disclosed sequences to the exclusion of material irrelevant to the identification of non-normal or cancerous breast cells.

[0100] To identify changes in sequence expression in non-normal or cancerous breast cells, abnormal epithelium from ADH, DCIS and IDC and phenotypically normal epithelium (henceforth referred to as normal) from 36 breast cancer patients and 3 healthy mammoplasty reduction patients were isolated via laser capture microdissection (LCM). The resulting 300 independently microdissected samples were used to interrogate a microarray containing approximately 12,000 human genes.

[0101] One important advantage provided by LCM use is the ability to procure both normal and diseased cell populations from the same biopsy. Therefore, the expression level of each gene in a disease state (ADH or DCIS or IDC) is represented as the ratio to the patient-matched normal, which highlights differences due to disease state as opposed to the genetic background of a particular patient. Unsupervised hierarchical clustering revealed one sequence cluster demonstrating increased expression in a majority of the diseased samples. CRIP1 was included in the cluster and identified as displaying increased expression levels in ADH with persistence in DCIS and IDC samples. Its increased expression may thus be a potential biomarker for the detection of breast cancer including the pre-malignant stage of ADH.

[0102] Sequences of another cluster demonstrated decreased expression in all three pathological stages. The epithelium-specific transcription factor ELF5 was included, and loss of expression of ELF5 in ADH may be an important first step in the initiation of breast malignancy.

[0103] Additional experiments resulted in the identification of increased expression of HN1 sequences in grade III DCIS and IDC cells.

[0104] Having now generally described the invention, the same will be more readily understood through reference to the following examples which are provided by way of illustration, and are not intended to be limiting of the present invention, unless specified.

EXAMPLES

Example I

[0105] Materials and Methods

[0106] Clinical specimen collection and clinicopathological parameters. All breast specimens were obtained from the Massachusetts General Hospital between 1998 and 2001. Thirty-six breast cancer patients were selected, 31 of which were diagnosed with two or more pathological stages of breast cancer progression, and 5 of which were diagnosed with pre-invasive disease only. Three healthy women who underwent elective mammoplasty reduction were selected as disease-free normal controls. Tissue specimens that demonstrated one or more pathological lesions (ADH, DCIS and IDC) were selected for the study. Cases of ADH were selected as proliferative epithelial lesions that possessed some, but not all, of the features of carcinoma in situ (Page, D. L. et al. (1992)) and most closely resemble those lesions described as CAPSS (Oyama, T. et al. and Fraser, J. L. et al.). DCIS and IDC were classified (histological grade) according to the European classification (Holland, R. et al.) and by the Nottingham combined histological grade (Elston, C. W. et al.), respectively. ER and PR expression were determined by immunohistochemical staining (negative when none of the tumor cell nuclei showed staining), and Her-2 expression determined by immunohistochemistry or FISH. This study was approved the Massachusetts General Hospital human research committee in accordance with NIH human research study guidelines.

[0107] LCM and RNA isolation and amplification. Each component (Normal, ADH, DCIS or IDC) was laser capture microdissected in triplicate (from consecutive tissue sections) as described (Sgroi et al.) using a PixCell II LCM system (Arcturus Engineering Inc., Mountain View, Calif.). Total RNA was extracted from the captured cells using the Picopure™ RNA Isolation Kit (Arcturus). T7-based RNA amplification was carried out using the RiboAmp™ kit (Arcturus). Briefly, the RNA from each sample was primed with an oligo-dT primer containing a T7 promoter sequence, reverse transcribed and then converted to double stranded cDNA. The cDNA templates were then used in an in vitro transcription reaction using T7 RNA polymerase to generate amplified RNA (aRNA). To obtain enough aRNA for a microarray experiment, a second round of RNA amplification was performed on all samples. To serve as reference in microarray hybridizations, a human universal reference RNA from Stratagene (La Jolla, Calif.) was amplified identically.

[0108] Fabrication of microarrays. Sequence-verified human cDNA clones were obtained from Research Genetics (Huntsville, Ala.). cDNA clones (from the I.M.A.G.E. Consortium via Research Genetics) inserts were amplified by PCR, gel-purified, and spotted onto a 1×3-inch SuperAmine™ (TeleChem International, Sunnyvale, Calif.) glass microscope slide using an OmniGrid™ robotic arrayer (GeneMachines, San Carlos, Calif.). As used herein, the I.M.A.G.E. Consortium CloneID, or the IMAGE CloneID, lists the identifiers of the cDNA clones on the microarrays according to the I.M.A.G.E. Consortium and Research Genetics (www.resgen.com/). This provides a unique single identifier for each clone. Descriptive names of clones (or genes) use the UniGene symbols and titles (www.ncbi.nlm.nih.gov/UniGene/).

[0109] Probe labeling and hybridization. cDNA was transcribed from aRNA in the presence of 5-(3-aminoallyl)-2′-deoxyuridine 5′-triphosphate (aminoallyl dUTP) using Stratagene's FairPlay kit™ (La Jolla, Calif.). Cy3 or Cy5 mono-reactive dye (Amersham, Piscataway, N.J.) was conjugated onto purified cDNA and the residual dye was removed using QiaQuick PCR Purification columns (Qiagen, Valencia, Calif.). Each Cy5-labeled cDNA was hybridized together with the Cy3-labeled reference probe to a microarray in 40 &mgr;L hybridization solution (5×SSC, 0.1 &mgr;g/&mgr;L COT I, 0.2%SDS, 50% formamide) at a concentration of 25 ng/&mgr;L per channel for 17 hrs at 42° C. in >60% relative humidity.

[0110] Washing, scanning and image analysis. After hybridization, slides were washed as follows: 1×SSC, 0.2% SDS at 42° for 5 min (two times), 1×SSC, 0.2% SDS at 55° C. for 5 min, 0.1×SSC, 0.2% SDS at 55° C. for 5 min and 0.1×SSC at RT for 2 min. Washed slides were scanned using ScanArray 5000 (PerkinElmer, Billerica, Mass.), and Cy5/Cy3-signals were quantitated using ImaGene 4.2 (BioDiscovery, Los Angeles, Calif.).

[0111] Data processing. Fluorescent intensities of Cy5 and Cy3 channels on each slide were subjected to spot filtering and normalization. Spots flagged by ImaGene were excluded from further analysis. Normalization was performed using a robust nonlinear local regression method (Yang, Y. H. et al.). The normalized ratios of Cy5/Cy3 were used to represent the relative gene expression levels in the experimental samples. Measurements from replicate samples were averaged after normalization.

[0112] Cluster and discriminant analysis. Hierarchical cluster analysis was performed in GeneMaths (v1.5, Applied-Maths, Austin, Tex.) using the cosine correlation coefficient as a measure of similarity between two genes or samples and complete linkage. Linear discriminant analysis with variance was performed within GeneMaths.

Example II

[0113] Analysis of Over and Under Expression

[0114] Quantitative real-time PCR analysis of CRIP1 and ELF5 was conducted to confirm their over and under expression in non-normal breast cells.

[0115] For the non-amplified RNA RT-PCR validation study, independently laser captured (˜40,000) normal breast epithelial cells from case 215, and ˜40,000 abnormal epithelial cells from DCIS (from cases 89, 178, 179) or IDC (from cases 97, 169, 170) were used. Total RNA was isolated and converted to double-stranded cDNA. For studies using amplified RNA (aRNA), 2 mgs of aRNA from each microdissected sample was converted into double-stranded cDNA. In all cases (cDNA derived from non-amplified and amplified RNA), the double-stranded cDNA was quantitated with PicoGreen (Molecular Probes) using a spectrofluorometer (Molecular Devices) and quantitative analysis of gene expression performed (RT-PCR) was performed with an ABI 7900HT (Applied Biosystems, Foster City, Calif.) as described (Sgroi et al., 1999).

[0116] Each reaction was performed in triplicate using 2.5 ng of double stranded cDNA from each sample as template. The relative standard curve method was used for linear regression analysis of unknown samples and data presented as fold change between samples. The sequences of the PCR primer pairs and fluorogenic probe (5′ to 3′), respectively, that were used for each gene are as follows: 6 CRIP1: CCTGCTACGCAGCCATGTT, GGATGGGTCTCCACCACCT, VIC-CGGAGCCGAGAGCCACACTTTCAAGT-TAMRA; ELF5: TGATTCCTGCTCTGGTGAAACA, ACATTTTCTCATCAATCA CTGGTATGT, VIC-CAGTCCACCTAGCTGTCAGTCACTGATA-TAMRA;

[0117] In agreement with microarray results used to initial identify sequences that were over and under expressed in non-normal breast cells, RT-PCR demonstrated over-expression of CRIP1 (>2-fold) in 7 of 8 ADH, 27 of 30 DCIS, and 23 of 25 IDC cases, and under-expression of ELF5 (>2-fold) in 7 of 8 ADH, 28 of 30 DCIS, and 25 of 25 IDC cases (FIG. 1).

[0118] In addition, we performed in-situ hybridization for CRIP1 to confirm its cellular specificity. As expected from the use of LCM, CRIP1 signal localized to the epithelial cells, and its intensity was markedly increased in the IDC compartment of the same biopsy (FIGS. 2 and 3), thus verifying the microarray-derived results at the level of cellular resolution.

[0119] All references cited herein, including patents, patent applications, and publications, are hereby incorporated by reference in their entireties, whether previously specifically incorporated or not.

[0120] Having now fully described this invention, it will be appreciated by those skilled in the art that the same can be performed within a wide range of equivalent parameters, concentrations, and conditions without undue experimentation. This application is intended to cover any variations, uses, or adaptations of the invention, following in general the principles of the invention, that include such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains and as may be applied to the essential features hereinbefore set forth.

Claims

1. A method to determine the presence of non-normal or abnormal breast cells in a sample from a human subject comprising assaying said sample for increased expression of one or more human CRIP1 or HN1 sequences.

2. The method of claim 1 wherein said assaying is for increased expression of human CRIP1 sequences.

3. The method of claim 1 wherein said assaying is for increased expression of human HN1 sequences.

4. The method of claim 1 wherein said sample is from a subject afflicted with, or suspected of having, breast cancer.

5. The method of claim 1 wherein said sample is obtained by solid tissue biopsy or a non-invasive procedure.

6. The method of claim 5 wherein said non-invasive procedure is selected from ductal lavage, fine needle aspiration, or a needle biopsy.

7. The method of claim 5 wherein microdissection is used to isolate breast cells from said sample before assaying for nucleic acid expression.

8. The method of claim 1 wherein said assaying is by hybridization to a polynucleotide comprising sequences of at least 24 nucleotides from the 3′ untranslated region, the coding region, or the 5′ untranslated region, of human CRIP1.

9. The method of claim 1 wherein said assaying is by hybridization to a polynucleotide comprising sequences of at least 24 nucleotides from the 3′ untranslated region, the coding region, or the 5′ untranslated region, of human HN1.

10. The method of claim 1 wherein said assaying is by PCR amplification of said sequences.

11. The method of claim 10 wherein said PCR is quantitative PCR.

12. The method of claim 1 wherein said non-normal cells are ADH, DCIS, or IDC cells.

13. A method to determine the presence of non-normal or abnormal breast cells in a sample from a human subject comprising assaying said sample for decreased expression of human ESE-2/ELF5 sequences.

14. The method of claim 13 wherein said sample is from a subject afflicted with, or suspected of having, breast cancer.

15. The method of claim 13 wherein said sample is obtained by solid tissue biopsy or a non-invasive procedure.

16. The method of claim 15 wherein said non-invasive procedure is selected from ductal lavage, fine needle aspiration, or a needle biopsy.

17. The method of claim 16 wherein microdissection is used to isolate breast cells from said sample before assaying for nucleic acid expression.

18. The method of claim 17 wherein said assaying is by hybridization to a polynucleotide comprising sequences of at least 24 nucleotides from the 3′ untranslated region, the coding region, or the 5′ untranslated region, of human ESE-2/ELF5.

19. The method of claim 13 wherein said assaying is by PCR amplification of said ESE-2/ELF5 sequence.

20. The method of claim 19 wherein said assaying is by quantitative PCR.

21. The method of claim 13 wherein said assaying is for inactivation or methylation of ESE-2/ELF5 sequences.

22. The method of claim 13 wherein said assaying comprises detection of increased mRNA degradation.

23. The method of claim 13 wherein said non-normal cells are ADH, DCIS, or IDC cells.

24. A polynucleotide comprising

a segment consisting of a fragment of an HN I sequence selected from SEQ ID NOS: 29-83 of between 24 and 500 nucleotides and

one or more non-HN1 nucleic acid molecules.

25. A polynucleotide consisting of a fragment of an HN1 sequence selected from SEQ ID NOS: 29-83 of between 24 and 500 nucleotides.

26. A population of singled stranded nucleic acid molecules comprising one or both strands of a human CRIP1 or HN1 sequence wherein at least a portion of said population is hybridized to one or both strands of a nucleic acid molecule quantitatively amplified from RNA of a non-normal or abnormal breast cell.

27. The population of claim 26 wherein the population is immobilized on a solid support.

28. The population of claim 27 wherein said solid support is a microarray.

29. The population of claim 26 wherein said nucleic acid molecules amplified from a non-normal or abnormal breast cell are amplified by quantitative real time PCR (RT-PCR).

30. The population of claim 29 wherein said quantitative RT-PCR is of amplified RNA of said breast cancer cell.

31. The population of claim 26 wherein said population of single stranded molecules is equal to or in excess of all of one or both strands of the nucleic acid molecules amplified from a non-normal or abnormal breast cell such that the population is sufficient to hybridize to all of one or both strands.

32. The population of claim 26 wherein said population of single stranded molecules comprising sequences of at least 24 nucleotides from the 3′ untranslated region, the coding region, or the 5′ untranslated region, of human CRIP1.

33. The population of claim 26 wherein said population of single stranded molecules comprising sequences of at least 24 nucleotides from the 3′ untranslated region, the coding region, or the 5′ untranslated region, of human HN1.

34. The population of claim 26 wherein said non-normal cells are ADH, DCIS, or IDC cells.