Lumen-measuring devices and method
The present invention provides a lumen measuring device and method that allows the user to calculate the exact length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure.
The present invention relates to measurement devices and methods and more particularly, to devices and methods of measuring the internal diameter of a lumen of a patient and the dimensions of luminal imperfection.
BACKGROUND OF THE INVENTIONPhysicians involved in therapy in general and interventional cardiology and interventional radiology in particular have been attempting to find a way to deal with occluded (so called “stenotic”) coronary arteries (among other blood vessels, various tubular conduits and similar structures). Additionally, the vessel diameter, as often measured using electronic calipers (‘imaging’ mode), and the frequency shift (‘Doppler’ mode) are of prime importance in determining the mean flow rate through a vessel and both must be accurately known. Unfortunately, methods of obtaining essential luminal dimensions have diverged based on inquiry; the physicians interested in interventional treatment of stenosis have approached the problem differently than those interested in determining mean flow rate through a vessel.
Interventional radiologists interested in treatment of stenosis have focused attention principally on the topology of the stenosis almost to the exclusion of other important factors. Of principal importance is the identification of stent length as a risk factor for restenosis. The usual method of choosing stent size relies on visual estimation from the angiogram. Like many practitioners interested in this area the goal has been to assess the value of an objective means of determining stent length. In one instance, a calibrated guide wire (ATW Marker wire; Cordis) is used as a measurement tool. J. P. Reilly et al. Use of ATW Marker Wire to Guide Choice of Stent Length, Am J Cardiol 2001; 88 (suppl 5A).
The theory behind this and other studies is that choice of appropriate endoluminal revascularization device (e.g., balloon angioplasty, atherectomy, laser recanalization, stents, etc) is a function of stenosis topology. Though excessive length of endoluminal revascularization devices can lead to migration and restenosis, a principal limitation of this analysis is that there are equally important risk factors associated with vessel diameter. Many practitioners pay more care in determining appropriate stent length than expanded stent diameter. As a rule of thumb, physicians generally employ a stent that is one to two sizes larger than the estimated lumen diameter. This practice in and of itself can lead to tissue granulation and further vessel damage.
Practitioners interested in hemodynamics or patency of vessels, defined as continued flow through the treated segment, not necessarily the absence of recurrent stenosis, use alternative tools to measure lumen diameter for purposes of determining the extent of flow there through. Most frequently, imaging tests such as CT Scans are used to assist with dimensional calculations. As a result, no apparatus has been developed that allows for accurate in situ measurement of treated or target tissue for purposes of evaluating patency and/or providing interventional prosthesis.
Therefore, there is an existing need for an accurate method of measuring both stenosis topography as well as luminal dimensions so that the precise interventional prosthesis may be employed. In particular, there is a need for a single device that can measure the width and height of a stenosis while also measuring the diameter of lumen at both healthy and stenotic regions.
SUMMARY OF EXEMPLARY EMBODIMENTSIt is a principal object in accordance with the present invention to provide a device capable of measuring the topology of a stenosis. In the furtherance of this and other objectives, a preferred embodiment of the present invention provides a measuring means that is disposable about, distal and proximal a stenosis for measuring the dimensions of the tissue in those locations.
Yet another objective in accordance with a preferred embodiment of the present invention is to provide a device that is suitable for measuring the working diameter of both healthy and diseased lumen for purposes of accurately determining the dimensions of an appropriate interventional prosthesis.
Still another objective of a preferred embodiment in accordance with the present invention is to provide a lumen measuring device and method that allows the user to calculate the exact length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure.
It is another objective in accordance with the present invention to provide a lumen-measuring device configured to be introduced into the working channel of a suitable anatomically correct optical scope. In the furtherance of this and other objectives, and provided by way of non limiting example only, a device in accordance with the present invention that is used for nonvascular indications in general and pulmonary indications in particular may be suitably configured for use in the working channel of a bronchoscope. It is envisioned that the optical instrument chosen will be a function of the general vascular/nonvascular decision, anatomical location, and physician preference.
Further objectives, features and advantages of the invention will be apparent from the following detailed description taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
A preferred embodiment in accordance with the present invention provides a lumen measuring device and method that allows the user to calculate the exact length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure. In the furtherance of this and other objectives, an exemplary device is capable of measuring the topology of a stenosis by providing a measuring means that is disposable about, distal and proximal a stenosis for measuring the dimensions of the tissue in those locations. Moreover, the device is suitable for measuring the working diameter of both healthy and diseased lumen for purposes of accurately determining the dimensions of an appropriate interventional prosthesis.
The device is capable of being introduced into the working channel of a suitable anatomically correct optical scope. For example, a device in accordance with the present invention that is used for nonvascular indications in general and pulmonary indications in particular may be suitably configured for use in the working channel of a bronchoscope. As discussed above, the optical instrument chosen will be a function of the general vascular/nonvascular decision, anatomical location, and physician preference.
Now making specific reference to the Figures where like numerals refers to like components, a lumen-measuring device is provided to give more accurate lumen dimensional information for purposes of interventional treatment. In particular, a lumen-measuring device 100 is provided generally in
In a preferred embodiment, the lumen-measuring device 100 comprises a plurality of conduits longitudinally extending between proximal and distal ends, namely exterior 130 and interior 180 conduits, the exterior conduit 130 is coupled with a handle 220 at the proximal end and a measurement assembly 240 at the distal end. The handle 220 and the measurement assembly 240 being operatively connected with one another via the interior conduit 180 at the interior conduit's proximal 190 and distal ends 200, respectively. The interior conduit 180 also has a depth marking mechanism 210 visible through the proximal region of the exterior conduit 140. The handle 220 provides a trigger mechanism 230 that allows the user to place the measurement assembly 240 in an open or closed configuration by pushing or pulling the trigger mechanism 230. The trigger 230 is preferably a slide-gauged mechanism but may be any number of alternative guiding systems known in the art. In the slide gauge embodiment, when the trigger mechanism 230 is pushed in a distal direction with respect to the handle 220, the interior conduit 180 urges the measurement assembly 240 distal the exterior conduit 130 causing the measurement assembly 240 to open. Retracting the trigger mechanism 230 in a proximal direction with respect to the handle 220 closes the measurement assembly 230.
The measurement assembly 230 comprises at least two legs 250, 300 having distal 260, 310 and proximal ends 270, 320 and inward facing 280, 330 and lumen facing 290, 340 surfaces, the legs are preferably coupled with each other at their respective proximal ends 270, 320. Distal the point at which the legs 250, 300 are coupled, the legs 250, 300 are designed to diverge from one another when unconstrained. In the furtherance of this objective, the legs 250, 300 are preferably formed of a shape memory alloy such as nitinol so that when the legs are constrained by the exterior conduit 130 they lay substantially flush with respect to one another but diverge when the exterior conduit 130 is evacuated.
Additional legs may be employed so that the topology of the lumen 570 may be assessed from varying perspectives. In a preferred embodiment, four legs are provided. Each leg is provided with measurement markers 350 that are disposed at predetermined intervals between the distal and proximal ends of each leg. Accuracy and corresponding leg dimensional measurements can be confirmed and calibrated by providing the lumen-measuring device 100 into a vessel with known interior dimensions. The legs are then urged distally until the distal ends of the legs touch the interior surface of the vessel. Since the interior dimensions of the vessel are known, it is easy to calibrate the measuring device so that the measurement markers correspond to the known dimensions.
As an added feature to ensure accuracy, preferred embodiments of the present device provide legs that have measurement markers 350 that are carved into the legs so as to form detent or lip catches 360. Depending on the embodiment described, markers 350 and lip catches 360 may be used interchangeably as one or both may be present in the same location. The exterior conduit 130 has corresponding detents 170 or a lip 170 about the distal end 150 thereof to ensure that the legs do not overshoot the maximum lumen measurement and damage the lumen tissue. Moreover, only moderate distal force is necessary to urge the legs beyond the lip 170, however, once the proper extension has been achieved, this feature allows the measuring assembly to remain stable until the calculation has been made.
Referring now to
In this and other related embodiments, the exterior conduit has measurement markers 160 formed thereon. Additionally, the lumen facing surfaces 280, 330 of the measurement assembly 240 legs have measurement markers 350 and/or 360 formed thereon. As the trigger mechanism 230 is pushed distally, the measurement assembly 240 moves distal the distal end 150 of the exterior conduit 130 and begins to separate the legs of the measurement assembly 240 with respect to one another. The further the trigger mechanisms 230 is pushed in the distal directions, the further the legs open and the greater the number of measurement markings 350 and/or 360 on the measurement assembly 240 extended beyond the distal end 150 of the exterior conduit 130. In a preferred embodiment, the distal end 150 of the exterior conduit 130 have inward facing detents or lip 170 that are complementary to the measurement markers 350 and/or 360 on the measurement assembly 240. At each measurement marking 350, the detent or lip 170 may be engaged by they detent catches 360 of the measurement marker 350 to prevent overshooting the target. Once the legs have been opened until the distal ends of the legs of the measurement assembly 240 are in contact with the tissue to be measured, the user need only count the measurement markings 350 to determine the desired dimensions of the target tissue.
In order to determine the length of the target tissue, the user need only open the measurement assembly 240 just proximal and just distal the target tissue, in no particular order and note the distances between the two locations on the depth marking mechanism 210 of the interior conduit 180, which is preferably just distal the handle 220.
An alternative embodiment of the present invention, as shown specifically in
The diameter measurement balloon 470 has substantially flat distal 480 and proximal 490 surfaces, with a substantially circular edge 500 there between, resulting in a hollow pancake shaped configuration. In a preferred embodiment, the diameter measurement balloon 470 has diameter measurement marker 510 of varying colors on the proximal and/or distal surface thereof to form a target like representation. Alternatively, the dilation balloon 430 has a substantially cylindrical shape with proximal 450 and distal ends 440 coupled along the outermost conduit 520.
When the pre-sterilized device is initially installed the diameter measurement balloon 470 is compressed proximal the distal tip 540 of the outermost conduit 520 and the dilation balloon 430 is compressed about the outermost conduit 520, proximal the diameter measurement balloon 470. In this configuration, as specifically shown in
Through the use of visualization means, such as optical instruments like a bronchoscope 110, the topology of the stenosis 580 can be directly viewed. The diameter measurement balloon 470 is preferably designed with diameter measurement markers 510 formed on the proximal face thereof to allow the user to visually measure the extent of luminal occlusion based on the number of diameter measurement markers covered by the stenosis 580 when viewing the diameter measurement balloon 470 from a position proximal the stenosis 580. Furthermore, this allows the physician to see if the stenosis 580, or other observed occlusion, is symmetrical, etc.
Simultaneously, the physician may observe the measurement markers 460, 510 visible through the outermost conduit 520 to see the dimensions of the occlusion from end-to-end or from specific points. Additionally, the dilation balloon 430 may also be inflated to serve as an additional measurement of the working diameter of the diseased lumen 570. To this end, the dilation balloon 430 is inflated until it substantially closes the diseased portion of the lumen 570.
Based on the measurements collected from this simple and inexpensive procedure, an interventional prosthesis may be selected, if necessary, that is appropriate in length and diameter so as to prevent further damage to the target lumen while providing sufficient outward radial support.
In this and other embodiments that employ balloons, a predetermined air pressure is provided to each balloon and each balloon conduit may be configured with a pressure manometer.
The present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative, and not restrictive. The scope of the invention is, therefore, indicated by the appended claims, rather than by the foregoing description. All changes, which come within the meaning and range of equivalency of the claims, are to be embraced within their scope.
Claims
1. A device that allows a user to calculate the length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure, the device comprising:
- an exterior conduit longitudinally extending between proximal and distal ends, the exterior conduit having measurement markers formed on a portion thereof;
- an interior conduit longitudinally extending between proximal and distal ends, disposed within the exterior conduit, and displaceable with respect to the exterior conduit, the interior conduit having a depth marking mechanism visible through a portion of the exterior conduit;
- a measurement assembly comprising at least two legs having distal and proximal ends and inward facing and lumen facing surfaces, the legs coupled with each other proximal the distal ends thereof, the measurement assembly also coupled about the distal end of the interior conduit;
- a handle operatively connected with the measurement assembly, the handle comprising a means for opening and closing the measurement assembly by actuating the handle along a continuum between a first closed configuration and a second open configuration.
2. The device of claim 1, wherein the inward facing surfaces of the legs are substantially flush with one another when the measurement assembly is closed.
3. The device of claim 2, wherein when the measurement assembly is moved distally in relation to the first conduit, the legs form an acute angle with respect to one another.
4. The device of claim 3, wherein the measurement assembly further comprises a third leg.
5. The device of claim 1, wherein the distal ends of the legs are coupled together, wherein measurement of the target site takes place between the distal and proximal ends thereof.
6. The device of claim 1, wherein the handle further comprises a measurement indicator, wherein target lumen dimensions are calculated based on the relative distance the handle travels along the continuum between the first and second handle locations.
7. A method of measuring a target segment of a lumen of a patient so as to select a suitable interventional prosthesis, the method comprising:
- providing a measuring device having an exterior conduit longitudinally extending between proximal and distal ends, the exterior conduit having measurement markers formed on a portion thereof; an interior conduit longitudinally extending between proximal and distal ends, disposed within the exterior conduit, and displaceable with respect to the exterior conduit, the interior conduit having a depth marking mechanism visible through a portion of the exterior conduit; a measurement assembly comprising at least two legs having distal and proximal ends and inward facing and lumen facing surfaces, the legs coupled with each other proximal the distal ends thereof, the measurement assembly also coupled about the distal end of the interior conduit; a handle operatively connected with the measurement assembly, the handle comprising a means for opening and closing the measurement assembly by actuating the handle along a continuum between a first closed configuration and a second open configuration;
- introducing the device into an appropriate anatomical orifice of a patient;
- delivering the device adjacent a target segment of a lumen within the patient; and
- measuring the length of the target segment of the lumen within the patient.
8. The method of claim 7, wherein the device further comprises an optical scope operatively coupled therewith, such that the measuring step is accomplished using the optical scope.
9. The method of claim 7, wherein the inward facing surfaces of the legs are substantially flush with one another when the measurement assembly is closed.
10. The method of claim 9, wherein when the measurement assembly is moved distally in relation to the first conduit, the legs form an acute angle with respect to one another.
11. The method of claim 10, wherein the measurement assembly further comprises a third leg.
12. The method of claim 7, wherein the distal ends of the legs are coupled together, wherein measurement of the target site takes place between the distal and proximal ends thereof.
13. The method of claim 7, wherein the handle further comprises a measurement indicator, wherein target lumen dimensions are calculated based on the relative distance the handle travels along the continuum between the first and second handle locations.
14. The method of claim 7, further comprising the step of measuring the diameter of the target segment of the lumen within the patient.
15. The method of claim 14, wherein the diameter measuring step comprises the step of actuating the handle along the continuum from the first closed configuration toward the second open configuration until the legs of the measurement mechanism come in contact with the target segment of the lumen and calculating the length as a function of the number of leg measurement markings distal the exterior conduit.
16. The method of claim 14, wherein the target segment of the lumen is stenotic.
17. The method of claim 7, wherein the device further comprises an optical scope operatively coupled therewith, such that the measuring step is accomplished using the optical scope.
18. The method of claim 16, further comprising the step of measuring the length of the stenosis.
19. The method of claim 18, wherein the delivering step further comprises the step of positioning the distal end of the first conduit distal the stenosis.
20. The method of claim 19, wherein the measurement mechanism is opened and placed distal the stenosis such that the exterior conduit is retracted and the stenosis length measurement is a function of the distance the exterior conduit is retracted proximally.
21. The method of claim 18, wherein the stenosis length measuring step comprises the step of actuating the handle along the continuum from the first closed configuration toward the second open configuration until the legs of the measurement mechanism come in contact with the target segment of the lumen and calculating the length as a function of the distance between the first handle position and the current point of the handle along the continuum.
22. The method of claim 16, further comprising the step of measuring the height of the stenosis.
23. The method of claim 22, further comprising the step of measuring the length of the stenosis.
24. A method of measuring a target segment of a lumen of a patient so as to select a suitable interventional prosthesis, the method comprising:
- providing a measuring device having an exterior conduit longitudinally extending between proximal and distal ends, the exterior conduit having measurement markers formed on a portion thereof; an interior conduit longitudinally extending between proximal and distal ends, disposed within the exterior conduit, and displaceable with respect to the exterior conduit, the interior conduit having a depth marking mechanism visible through a portion of the exterior conduit; a measurement assembly comprising four legs having distal and proximal ends and inward facing and lumen facing surfaces, the legs coupled with each other proximal the distal ends thereof, the measurement assembly also coupled about the distal end of the interior conduit; a handle operatively connected with the measurement assembly, the handle comprising a means for opening and closing the measurement assembly by actuating the handle along a continuum between a first closed configuration and a second open configuration;
- introducing the device into an appropriate anatomical orifice of a patient;
- delivering the device adjacent a target segment of a lumen within the patient; and
- measuring the diameter of the target segment of the lumen within the patient.
25. A device that allows a user to calculate the length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure, the device comprising:
- a diameter measurement balloon comprising substantially flat distal and proximal surfaces, with a substantially circular edge there between, the diameter measuring balloon having diameter measurement markers on the proximal and/or distal surface thereof;
- a dilation balloon that has a substantially cylindrical shape with proximal and distal ends;
- a plurality of conduits, a diameter measurement conduit for inflating the diameter measurement balloon, a dilation conduit for inflating the dilation balloon and an outermost conduit, the outermost conduit having proximal and distal ends and measurement markings there between, the diameter measurement conduit and the dilation conduit disposed within the outermost conduit such that the dilation balloon and the diameter measurement balloon are coupled along the outermost conduit yet operatively coupled with the dilation and measurement conduits, respectively through the outermost conduit.
26. The device of claim 25, wherein the plurality of conduits are co-extruded.
27. A method of measuring a target segment of a lumen of a patient so as to select a suitable interventional prosthesis, the method comprising:
- providing a measuring device having a diameter measurement balloon comprising a substantially flat distal and proximal surfaces, with a substantially circular edge there between, the diameter measuring balloon having diameter measurement markers on the proximal and/or distal surface thereof; a dilation balloon that has a substantially cylindrical shape with proximal and distal ends; a plurality of conduits, a diameter measurement conduit for inflating the diameter measurement balloon, a dilation conduit for inflating the dilation balloon and an outermost conduit, the outermost conduit having proximal and distal ends and measurement markings there between, the diameter measurement conduit and the dilation conduit disposed within the outermost conduit such that the dilation balloon and the diameter measurement balloon are coupled along the outermost conduit yet operatively coupled with the dilation and measurement conduits, respectively through the outermost conduit;
- introducing the device into an appropriate anatomical orifice of a patient;
- delivering the device adjacent a target segment of a lumen within the patient; and
- measuring the specific dimensions of the target segment of the lumen within the patient.
28. The method of claim 27, wherein the device further comprises an optical scope operatively coupled therewith, such that the measuring step is accomplished using the optical scope.
29. The method of claim 27, wherein the target segment of the lumen is stenotic.
30. The method of claim 29, wherein the specific dimensions of the target segment is selected from the group consisting of length, height, circumference, radius, diameter and combinations thereof.
31. A device that allows a user to calculate the length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure, the device comprising:
- a diameter measurement balloon comprising substantially flat distal and proximal surfaces, with a substantially circular edge there between, the diameter measuring balloon having diameter measurement markers on the proximal and/or distal surface thereof;
- a dilation balloon that has a substantially cylindrical shape with proximal and distal ends;
- a tube having and interior and an exterior, the interior defining three apertures passing at least partially there through, the first aperture comprising a diameter measurement conduit for inflating the diameter measurement balloon, the second aperture comprising a dilation conduit for inflating the dilation balloon and an third aperture that extends the length thereof, the third aperture comprising a working channel, the diameter measurement conduit and the dilation conduit disposed within the tube conduit such that the dilation balloon and the diameter measurement balloon are coupled along the exterior of the tube yet operatively coupled with the dilation and measurement conduits, respectively through the outermost conduit.
32. A method of measuring a target segment of a lumen of a patient so as to select a suitable interventional prosthesis, the method comprising:
- providing a measuring device having a diameter measurement balloon comprising a substantially flat distal and proximal surfaces, with a substantially circular edge there between, the diameter measuring balloon having diameter measurement markers on the proximal and/or distal surface thereof; a dilation balloon that has a substantially cylindrical shape with proximal and distal ends; a tube having and interior and an exterior, the interior defining three apertures passing at least partially there through, the first aperture comprising a diameter measurement conduit for inflating the diameter measurement balloon, the second aperture comprising a dilation conduit for inflating the dilation balloon and an third aperture that extends the length thereof, the third aperture comprising a working channel, the diameter measurement conduit and the dilation conduit disposed within the tube conduit such that the dilation balloon and the diameter measurement balloon are coupled along the exterior of the tube yet operatively coupled with the dilation and measurement conduits, respectively through the outermost conduit;
- introducing the device into an appropriate anatomical orifice of a patient;
- delivering the device adjacent a target segment of a lumen within the patient; and
- measuring the specific dimensions of the target segment of the lumen within the patient.
33. The method of claim 32, wherein the device further comprises an optical scope operatively coupled therewith, such that the measuring step is accomplished using the optical scope.
34. The method of claim 32, wherein the target segment of the lumen is stenotic.
35. The method of claim 34, wherein the specific dimensions of the target segment is selected from the group consisting of length, height, circumference, radius, diameter and combinations thereof.
36. The device of claim 35, wherein the tube further comprises proximal and distal ends and measurement markings there between.
37. A device that allows a user to calculate the length and diameter of a suitable interventional prosthesis as well as the height and length of stenosis during the same exploratory procedure, the device comprising:
- an exterior conduit longitudinally extending between proximal and distal ends, the exterior conduit having measurement markers formed on a portion thereof;
- an interior conduit longitudinally extending between proximal and distal ends, disposed within the exterior conduit, and displaceable with respect to the exterior conduit;
- a measurement assembly comprising a plurality of legs having distal and proximal ends and inward facing and lumen facing surfaces, the legs coupled with each other proximal the distal ends thereof, the measurement assembly also coupled about the distal end of the interior conduit;
- a handle operatively connected with the measurement assembly, the handle comprising a means for opening and closing the measurement assembly by actuating the handle along a continuum between a first closed configuration and a second open configuration.
38. The device of claim 37, wherein the inward facing surfaces of the legs are substantially flush with one another when the measurement assembly is closed.
39. The device of claim 38, wherein when the measurement assembly is moved distally in relation to the first conduit, the legs form an acute angle with respect to one another.
40. The device of claim 39, wherein the measurement assembly comprises four legs.
41. The device of claim 37, wherein the distal ends of the legs are coupled together, wherein measurement of the target site takes place between the distal and proximal ends thereof.
42. The device of claim 37, wherein the handle further comprises a measurement indicator, wherein target lumen dimensions are calculated based on the relative distance the handle travels along the continuum between the first and second handle locations.
Type: Application
Filed: Jul 11, 2003
Publication Date: Jan 13, 2005
Inventors: Eric Mangiardi (Charlotte, NC), Jason Reynolds (Charlotte, NC), Ulf Borg (Cornelius, NC), Tony Alexander (Charlotte, NC)
Application Number: 10/618,223