Internal shunt and method for treating glaucoma
A surgical technique wherein an indwelling shunt is placed in the eye of a patient having glaucoma. The shunt diverts aqueous humor from a deep scleral lake or directly from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intra-ocular pressure. The indwelling shunt maintains the area of exposure of aqueous humor with the uvea by physically preventing scarring of the surrounding tissues. The method utilizes the 25 mm Hg driving force of the protein colloidal osmotic pressure of the blood to maximize the flow.
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This invention pertains to a surgical treatment for glaucoma and, more particularly, to a new method and apparatus for surgically alleviating the intraocular pressure causing the glaucoma condition.
BACKGROUND OF THE INVENTIONGlaucoma is an eye condition in which the hydrostatic pressure within the eye is abnormally high, thereby resulting in damage to the optic nerve. There are many treatments for the glaucoma condition that involve lowering the intraocular pressure, either by means of medication or surgery.
Medicinal treatments either decrease the rate at which aqueous humor is pumped into the eye or improve the outflow of aqueous humor from the eye.
There are three primary surgical methods for treating glaucoma. Presently, none of them are a complete answer to the problem:
a) Cyclodestructive procedures damage the ciliary body of the eye and decrease the rate of aqueous humor production. The main problem is the extremely fine dividing line between too little and too much treatment. This treatment often does not work, or it works too well. When the surgery works too well, a hypotonous eye may develop in which the pressure is too low for normal ocular function and health.
b) Laser therapy of the trabecular meshwork is used to decrease the resistance of outflow of aqueous humor into the Canal of Schlemm. The main problem with this procedure is that it only provides relief for about five years. Re-treatment is often unsuccessful because it may cause too much scarring of the outflow channels. Thus, this procedure can do more harm than good.
c) Shunting of aqueous humor from the anterior chamber through the sclera to outside of the confines of the eye is the most common surgical procedure. Among the shunting procedures, the often-performed trabeculectomy is a type of filtering method. It allows aqueous humor to “filter” out of the eye. A channel is created from the anterior chamber under a scleral flap to the episcleral space. The main problem with this procedure is that the outcome depends on the individual healing properties of the eye in the post-operative period. Trabeculectomy is often much less successful in highly pigmented eyes and eyes with previous surgery, rubeosis, or chronic uveitis. To overcome this problem, several shunts have been devised to carry aqueous humor from the anterior chamber to the episcleral space. Scarring often occurs surrounding the exterior end when shunts are used. This renders the outcome unpredictable.
Another problem with these types of surgical procedures is that the globe is left with a transcleral fistula. The fistula renders the eye susceptible to the ingress of organisms and intraocular infection. This condition is known as endophthalmitis and can be devastating to the eye, since the eye is not naturally designed to defend against this type of onslaught.
The invention seeks to provide a surgical treatment and apparatus that will overcome the many problems associated with present-day surgical procedures.
The current invention provides an indwelling shunt that diverts aqueous humor from the anterior chamber to the blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure of the glaucomatous eye. The indwelling shunt maintains the area of exposure of aqueous humor with the uvea by physically preventing scarring of the surrounding tissues. The method utilizes the normally occurring 25 mm Hg driving force of the protein colloid osmotic pressure of the blood to maximize the flow of aqueous humor out of the eye (Yablonski, M. E., J of Glaucoma, February 2003, 12(1):90-92).
One of the many problems that this inventive procedure overcomes is the normally low outflow of aqueous humor into the uveal blood caused by the normally low hydraulic permeability between the aqueous humor of the anterior chamber and the uveal blood vessels (Yablonski, ibid.). The internal tube shunt of this invention, however, greatly increases the hydraulic permeability between the aqueous humor and the uveal blood vessels, thus greatly increasing the magnitude of the outflow via this route.
The present invention overcomes the two main objections of most of the current surgical approaches: (a) it requires no permanent transcleral route for the egress of aqueous humor from the eye, and (b) the success of the procedure is not as dependent on the individual healing properties of the eye as it is in other procedures. Therefore, the inventive technique not only works in younger eyes, but it also works in eyes of darkly pigmented individuals, and eyes of patients who have had previous surgery. In addition, the inventive procedure leaves no transcleral route in the eye, thus decreasing the susceptibility to endophthalmitis.
DISCUSSION OF RELATED ARTIn an article by Stegmann (1990), a procedure is described wherein a non-penetrating deep sclerectomy is performed. The procedure was called “viscocanulostomy” because a viscoelastic substance was injected into the cut ends of the canal of Schlemm after the canal was exposed. Like the present technique, Stegmann first created a thin scleral flap, then created a deep sclerectomy by removing the deep sclera, leaving only a thin layer of sclera of 50 to 100 microns in thickness overlying the choroidal tissue beneath.
It should be observed that Stegmann sutured the overlying scleral flap very tightly, thereby eliminating a final transcleral route for aqueous humor drainage. This implied that the intended mechanism for aqueous humor egress was an intraocular shunt. The mechanism of action of the procedure was proposed by Stegmann to be the access of aqueous humor to the newly dilated canal of Schlemm, from which it flowed from the eye by the usual outflow routes. However, if this were the case, the outflow facility of the eyes should be increased, as measured by tonography. No studies have shown an increase in outflow facility after the viscocanulostomy is performed, despite a marked decrease in intraocular pressure.
Another related technique to that of the current invention is the procedure that sutures a collagen implant beneath the scleral flap into the bed of the deep sclerectomy (M. E. Karlen, E. Sanchez, C. C. Schnyder, M. Sickenberg, and A. Mermoud, Deep sclerectomy with collagen implant: medium term results, Br J Ophthalmol, January 1999, 83(1):6-11). The method provides a non-penetrating deep sclerectomy wherein a collagen implant is placed between the overlying scleral flap and the underlying suprachoroidal space. No dilation of the canal of Schlemm is performed. No flow of aqueous humor into the uveal blood is suggested, and only two scleral flap sutures are used, which renders the scleral flap permeable to transcleral flow and creates a transcleral fistula.
In U.S. Pat. No. 6,383,219, issued on May 7, 2002 to Telandro et al., a related non-penetrating deep sclerectomy is illustrated. The method uses an implant made of a cross-linked hydraluronic acid material, which is shaped like a polyhedron having at least five faces. The material is placed between the overlying scleral flap and the underlying suprachoroidal scleral bed. Unlike the current inventive method, this procedure does not propose that the aqueous humor flows mainly into the adjacent uveal blood in response to its protein colloid osmotic pressure. The use of only two sutures in the overlying scleral flap renders this flap permeable to transcleral flow, creating a transcleral fistula.
The stated mechanism for relief in Telandro et al. is the high water content that acts like a wick, i.e., it transports the ocular fluids by capillary action. No mention is made of flow of aqueous humor into the uveal blood, and it is implied that the final destination of the flow of aqueous humor is across the overlying scleral flap into the episcleral space. This method is similar to a conventional trabeculectomy and other filtering procedures.
Some internal shunts have previously been proposed. In U.S. Pat. No. 6,450,984, issued to Lynch and Brown on Sep. 17, 2002, a shunt is illustrated that shunts fluid from the anterior chamber. The shunt is placed under a scleral flap and into the open ends of the canal of Schlemm. This method requires normal drainage of aqueous humor from the canal of Schlemm into the episcleral veins. Since in open angle glaucoma, which is the most common type of glaucoma, flow through the canal of Schlemm is impaired, this technique appears flawed. To the best of knowledge and belief, no reports exist in the literature depicting the successful implementation of this technique.
In U.S. Pat. No. 5,601,094, issued on Feb. 11, 1997 to Reiss, a shunt is described which causes flow of aqueous humor from the anterior chamber to the suprachoroidal space. Unlike the present invention, however, the shunt is exteriorized before it enters the supracharoidal space. This renders the eye susceptible to endopthalmitis. To the best of knowledge and belief, there have been no successful reports for this technique in the literature.
In U.S. Pat. No. 4,521,210, issued on Jun. 4, 1985 to Wong, a shunt is illustrated that extends from the anterior chamber to the suprachoroidal space. The shunt is designed to create a permanent cyclodialysis cleft and shunt aqueous fluid to the supracharoidal space from the anterior chamber. The suprachroidal space is surgically entered and the ciliary body disinserted from the scleral spur. To the best of knowledge and belief, there have not been any reports in the literature of the success of this technique.
SUMMARY OF THE INVENTIONIn accordance with the present invention, a surgical technique and apparatus are illustrated for alleviating the glaucoma condition. The current invention provides an indwelling shunt that diverts aqueous humor from the anterior chamber to the blood flowing in the choroidal and uveal tissues. This decreases the intra-ocular pressure. The indwelling shunt maintains the area of exposure of aqueous humor with the uvea by physically preventing scarring of the surrounding tissues. The method utilizes the 25 mm Hg driving force of the protein colloidal osmotic pressure of the blood to maximize the flow.
One method illustrated in
After suturing, one end of the tube is in the suprachoroidal space and the other is in the scleral lake created by the deep sclerectomy. Then a trabeculectomy specimen is created, plus a peripheral iridectomy, as in a standard trabeculectomy. The scleral flap is turned back to its normal position resting on the deep scleral shelf and is sutured to the adjacent sclera with six to ten interrupted sutures to yield a tight closure. The shunt can be fabricated from silicone or other biocompatible materials. One or two such tubes can be placed on each lateral side of the deep sclerectomy. These tubes not only shunt aqueous humor from the scleral lake into the suprachoroidal space, they also help maintain the volume of the scleral lake by acting as a physical barrier between the overlying scleral flap and the underlying scleral bed.
In another version of this procedure (
It is an object of this invention to provide an improved surgical technique and apparatus for treating glaucoma.
It is another object of the present invention to provide both a surgical method and an apparatus that utilizes the uveal blood vessels to drain aqueous humor from the anterior chamber of the eye to decrease intra-ocular pressure in the treatment of glaucoma.
BRIEF DESCRIPTION OF THE DRAWINGSA complete understanding of the present invention may be obtained by reference to the accompanying drawings, when considered in conjunction with the subsequent detailed description, in which:
For purposes of brevity and clarity, like components and elements of the apparatus of this invention will bear the same designations or numbering throughout the FIGURES.
DESCRIPTION OF THE PREFERRED EMBODIMENTGenerally speaking, a surgical technique and apparatus is described wherein an indwelling shunt is placed in the eye of patients having glaucoma. The shunt diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by the blood flowing in the choroidal and uveal tissues. This decreases the intra-ocular pressure. The indwelling shunt maintains the area of exposure of aqueous humor with the uvea by physically preventing scarring of the surrounding tissues. The method utilizes the 25 mm Hg driving force of the protein colloidal osmotic pressure of the blood to drive aqueous humor into the blood.
In
The method comprises the initial step of folding back the scleral flap 4 of the eye (
After suturing the tube 1 in place, a trabeculectomy specimen 5 may be removed, thus creating a direct communication to the anterior chamber 21 (best seen in
Referring to
Referring now to
Referring now to
Referring to
In this version, the deep sclerectomy is smaller than the deep scleral lake 8 shown in
Since other modifications and changes varied to fit particular operating requirements and environments will be apparent to those skilled in the art, the invention is not considered limited to the examples chosen for purposes of disclosure and covers all changes and modifications which do not constitute departures from the true spirit and scope of this invention.
Having thus described the invention, what is desired to be protected by Letters Patent is presented in the subsequently appended claims.
Claims
1. A method of surgically treating glaucoma, comprising the steps of:
- a) placing a shunt below scleral tissue of an eye in order to divert aqueous humor from a scleral lake to a suprachoroidal space from which said aqueous humor is removed by blood flowing in choroidal and uveal tissues, whereby intra-ocular pressure is reduced;
- b) maintaining an area of exposure of said aqueous humor with uveal tissue by physically preventing scarring of surrounding tissues; and
- c) utilizing osmotic pressure of the blood to maximize flow of said aqueous humor from said scleral lake.
2. The method of surgically treating glaucoma in accordance with claim 1, wherein said shunt comprises an indwelling shunt remaining within the confines of the globe of said eye.
3. The method of surgically treating glaucoma in accordance with claim 1, wherein said shunt comprises a hollow tube.
4. The method of surgically treating glaucoma in accordance with claim 3, wherein said hollow tube is precut prior to surgery.
5. The method of surgically treating glaucoma in accordance with claim 4, wherein said hollow tube has polished edges.
6. The method of surgically treating glaucoma in accordance with claim 4, wherein said hollow tube has an attached suture and needle for suturing said hollow tube to said scleral tissue.
7. The method of surgically treating glaucoma in accordance with claim 1, wherein said shunt placing step (a) further comprises the step of inserting said shunt into a suprachoroidal space of said eye.
8. The method of surgically treating glaucoma in accordance with claim 1, further comprising the step of:
- d) suturing said shunt within said eye.
9. A method of surgically treating glaucoma, comprising the steps of:
- a) creating a scleral flap in scleral tissue of an eye;
- b) performing a deep sclerectomy creating a deep scleral lake;
- c) placing a tube-like shunt in a space below said scleral flap;
- d) diverting aqueous humor from said deep scleral lake to an adjacent suprachoroidal space;
- e) utilizing osmotic pressure of the blood flowing in choroidal and uveal tissues to maximize flow of said aqueous humor from said deep scleral lake to said adjacent suprachoroidal space.
10. The method of treating glaucoma in accordance with claim 9, further comprising the step of:
- f) maintaining an area of exposure of said aqueous humor with uveal tissue, by physically preventing scarring of surrounding tissues.
11. The method of surgically treating glaucoma in accordance with claim 10, wherein said tube-like shunt comprises a hollow tube with polished edges.
12. The method of surgically treating glaucoma in accordance with claim 11, wherein said hollow tube is precut prior to surgery.
13. The method of surgically treating glaucoma in accordance with claim 12, wherein said hollow tube has polished edges.
14. The method of surgically treating glaucoma in accordance with claim 12, wherein said hollow tube has an attached suture and needle.
15. The method of surgically treating glaucoma in accordance with claim 9, wherein said placing a tube-like shunt step (c) further comprises the step of inserting said tube-like shunt into a suprachoroidal space of said eye.
16. The method of surgically treating glaucoma in accordance with claim 9, further comprising the step of:
- f) suturing said tube-like shunt within said eye.
17. A device for the surgical treatment of glaucoma comprising a longitudinal structure comprising biologically compatible material that shunts aqueous humor from a deep scleral lake to the adjacent suprachoroidal space.
18. The device in accordance with claim 17, further comprising an internal shunt remaining within the confines of the globe of an eye.
19. The device in accordance with claim 18, further comprising a hollow tube, precut prior to surgery, wherein said hollow tube has polished edges, and said hollow tube has an attached suture and needle at one end for suturing said hollow tube.
20. The device in accordance with claim 18, further comprising a shunting structure wherein said structure is a grooved material, an open celled foam material, or a porous material.
21. A method of surgically treating glaucoma, comprising the steps of:
- a) creating a posterior scleral flap in the scleral tissue of an eye;
- b) creating a posterior deep sclerectomy beneath said posterior scleral flap;
- c) placing the anterior end of a tube-like shunt in a space below said posterior scleral flap through said scleral tissue into an anterior chamber of said eye;
- d) placing the posterior end of said tube-like shunt into a posterior suprachoroidal space;
- e) diverting aqueous humor directly from said anterior chamber to said posterior suprachoroidal space via said tube-like shunt from said anterior chamber through said adjacent scleral tissue, under said posterior scleral flap into said posterior suprachoroidal space; and
- f) utilizing osmotic pressure of the blood to maximize the flow of said aqueous humor from said posterior suprachoroidal space into blood flowing in choroidal and uveal tissues.
22. The method of treating glaucoma in accordance with claim 21, further comprising the step of:
- g) maintaining an area of exposure of said aqueous humor with said uveal tissue, by physically preventing scarring of surrounding tissues.
23. The method of surgically treating glaucoma in accordance with claim 21, wherein said tube-like shunt comprises a hollow tube.
24. The method of surgically treating glaucoma in accordance with claim 23, wherein said hollow tube is precut prior to surgery.
25. The method of surgically treating glaucoma in accordance with claim 24, wherein said hollow tube has polished edges.
26. The method of surgically treating glaucoma in accordance with claim 25, wherein said hollow tube has an attached suture and needle in the posterior end of said hollow tube for fixation to said scleral tissue overlying said hollow tube.
27. The method of surgically treating glaucoma in accordance with claim 21, further comprising the step of:
- g) suturing said tube-like shunt within said eye.
28. A device for the surgical treatment of glaucoma comprising a longitudinal structure composed of biologically compatible material that shunts aqueous humor from the anterior chamber through the sclera into the suprachoroidal space, without creating a permanent cyclodialysis cleft and disinserting the ciliary body from a scleral spur.
29. The device in accordance with claim 28, wherein said longitudinal structure comprises an internal shunt remaining within the confines of the globe of an eye.
30. The device in accordance with claim 29, further comprising a hollow tube, precut prior to surgery, wherein said hollow tube has polished edges, and said hollow tube has an attached suture and needle at one end for suturing said hollow tube.
31. The device in accordance with claim 29, further comprising a shunting structure wherein said structure is selected from the group: a grooved material, an open celled foam material, and a porous material.
32. The device in accordance with claim 31 wherein said structure is precut prior to surgery, and said structure has an attached suture and needle at one end for suturing said structure.
Type: Application
Filed: Aug 23, 2006
Publication Date: Jun 28, 2007
Applicant: (Eugene, OR)
Inventor: Michael Yablonski (Vestal, NY)
Application Number: 11/509,327
International Classification: A61M 5/00 (20060101);