BREATH CONDENSATE COLLECTOR
A breath condensate collector (10) comprising a chamber having a breath inlet port (14) and an outlet port (16); a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means (112) to promote in use condensation of vapour from breath entering the sample collector and where the sample collector comprises a partially lidded dish (110).
This invention concerns apparatus for the collection of breath condensate and also apparatus specifically for collection of breath condensate from animals, especially horses and humans.
BACKGROUND AND PRIOR ART KNOWN TO THE APPLICANTBreath Condensate collectors are known. For example, application number GB 2427686 discloses, in its broadest aspect:
A breath condensate collector comprising: a chamber having a breath inlet port, an air inlet port and an outlet port; a one-way valve, located in said air inlet port, to allow flow of air into the chamber, whilst resisting flow of air or breath out of the chamber; a sample collector, adapted to receive air from the chamber outlet, and having air exhaust means; cooling means, to promote, in use, condensation of vapour from breath entering the sample collector; and characterised by the feature that the flow path from the breath inlet port to the sample collector is unimpeded by a valve.
Application GB 2427686 also discloses the following prior art:
Determination of the concentration of metabolites present in exhaled breath is useful for a number of clinical indications. One such metabolite is hydrogen peroxide, and elevated levels of this in exhaled breath can be indicative of pulmonary dysfunction. Apparatus for the collection breath condensate are known in themselves. One such device is illustrated in
In one such type of apparatus, the upper valve 3, is of a so-called “duckbill” configuration—a generally dome-shaped configuration, made of a rubber-like material, and having a slit at the domed end, forming a pair of lip-like structures. This is illustrated in cross-section in
The passage of air through the valve systems also tends to offer some resistance to breathing. For informed and cooperative users, with relatively good lung function, this is usually not problematic, but can become a significant drawback in situations where communication with the patient, or subject, is difficult.
In addition, devices of this nature require the user to consciously breathe through their mouths, rather than through their nose. Again, when used with informed and cooperative users this is usually not problematic, but can become problematic where communication with the patient, or subject, is difficult.
Finally, devices of this nature are relatively complex, and require multiple one-way valves, located within the body of a narrow tube, in order to function. This tends to increase manufacture costs.
All of these problems with current devices become especially heightened in the field of veterinary, and especially equine, healthcare. In these situations, the subject animal is likely to be restless, uncooperative, and easily alarmed. On top of this, meaningful communication is impossible.
Since that invention, it has been discovered that the type of sample collected in conventional collectors usually comprises a mixture of aerosol and true condensate.
None of the current breath condensate collectors facilitates the collection of both types of sample separately.
Both are useful to the analyst, but for different diagnostic purposes. As there is therefore a need for a condensate collector, which makes easy the collection of samples enriched in condensate or aerosol.
In addition, it has been observed that existing breath condensate collection technology can cause problems for those who need to take a quick sample—perhaps for a drug test before a horse race—or those who need to take a sample outside of a well—equipped clinical environment, such as travelling vets.
Of course, such environments present a greater risk of contamination to samples, and the high risk of contamination is something which previous examples of the art have suffered, perhaps due to their complexity, or perhaps due to the difficulties presented to the person who would try to clean them.
It is an object of the present invention to attempt to provide a solution to these and other problems.
SUMMARY OF THE INVENTIONIn its broadest aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and where the sample collector comprises a partially lidded dish.
Samples will collect in both the chamber and the sample collector. Samples in the chamber will be condensate rich; Samples in the sample collector will be aerosol rich.
By partially lidded dish, it is meant that the area of the opening of the dish is less than the cross sectional area of the dish's interior immediately beneath the opening.
The partially lidded dish is advantageous over fully open receptacles in that when air flows into the dish, it will not immediately deflect back out of the dish again. Instead, a large proportion of the breath will hit the inside of the lid. Unable to vacate the sample collector, it is caused to swirl around. Such swirling will lead to the deposition of more condensate and aerosol from the breath, into the dish itself. This gives a larger sample, and may also have more diagnostic value, since parts of the sample more easily carried by the air will be more likely to settle in the dish.
The partially lidded dish is further advantageous in relation to open dishes in that it provides a smaller target for contamination.
The invention is further advantageous in that both the chamber and the sample collector may be used to collect condensate. In other words, the invention provides a breath collection apparatus, having two sample collection recipients: one with a collection surface substantially parallel to the flow of breath for collection of a sample primarily comprising breath condensate and a second recipient with a collection surface substantially perpendicular to the flow of breath (such that the breath flow impinges on the collection surface thereby causing breath borne aerosol droplets to impact on the collection surface) for collection of sample containing condensate and enriched with breath—borne aerosol. Given that it has been proven that each sort of condensate has its own value, this may prove particularly useful in cases where a comparative study is desirable, and further or alternatively in situations where tests on both samples may advantageously be taken, or further where the right test has yet to be ascertained, and therefore either or both samples may prove useful.
Still more advantageous is the fact that both samples may be collected almost simultaneously, via one exhalation from the subject. This is quicker, and this speed is useful when the very act of procuring the sample is putting an animal under stress.
In any aspect of invention, it is preferable that the chamber is cylindrical.
It is advantageous to have a cylindrical chamber because it is easier to scrape the condensate out of a cylinder—none of it will be stuck in corners, or at the intersection between planes, as would happen with a rectangular or a pyramidal chamber. As has been mentioned, the condensate collected in the cylinder has particular diagnostic value and as such it is especially important that collection should be made easier.
For the same reason, it is easier to clean cylindrical tubes. This is particularly important where tests may be for a contagious disease, because hygiene will be paramount in those circumstances.
Also, in any aspect of invention, it is preferable that at least a part of the chamber is tapered.
The tapered chamber is particularly advantageous in that it disrupts air passing down it, creating turbulent rather than laminar flow conditions. This has two subsidiary advantages in itself.
The first is that the turbulence tends to cause more condensate and aerosol to drop out of the air.
The second is that turbulent flow leads to the formation of a thinner boundary layer on the inside of the tube, which itself increases condensation.
Also, in any aspect of invention, it is preferable that at least a part of the inner surface of the chamber comprises a hydrophobic material.
This is particularly advantageous in that hydrophobic material will encourage the condensate to form droplets, rather than spread out and “wet” the surface. This will lead to faster and more effective collecting of condensate from the chamber.
It is also advantageous in that the provision of a hydrophobic surface will tend to aid the flowing of the condensate from chamber to sample collector, especially when held at such an angle as to encourage such flow.
Also, in any aspect of invention, it is preferable that at least part of the inner surface of the sample collector comprises a hydrophobic material.
This is particularly advantageous in that hydrophobic material will encourage the condensate to form droplets, rather than spread out and “wet” the surface. This will lead to faster and more effective collecting of condensate from the sample collector.
Also, in any aspect of invention, it is preferable that the cooling means comprises a Peltier device.
The provision of a Peltier device is advantageous, in that it provides a manner of controlling the temperature of a sample collector placed adjacent to it, to a high degree of precision.
A second advantage is that the Peltier device will tend to cool for longer than other means, such as a gel wrapper or the provision of cold—retentive materials.
The most important advantage of all is that unlike the gel wrapper and the cold retentive materials, the Peltier device provides its own means for displacing heat—it is integral to the condensate collector and is not reliant on external sources for cooling. This will be of particular utility to the travelling veterinarian, for example, who may need to take samples of condensate on an ad hoc basis, and away from the external refrigeration means that would be required to cool other cooling means to the requisite temperature.
Also, in any aspect of invention, it is preferable that the breath condensate collector further comprises a wand.
It is particularly advantageous to include a wand in the apparatus, as the wand may be used to collect condensate from the chamber and the sample collector.
Also, in any aspect of invention, it is preferable that the wand is tapered.
The wand will be of advantage in that when held correctly, the taper will encourage the condensate to run along the wand and form at the tip, allowing for ease of collection.
Also, in any aspect of invention, it is preferable that the wand is resiliently deformable.
Advantageously, the resiliently deformable wand will deform to match the profile of the inside of the condensate collector, allowing the wand to scrape or wipe in a quicker and more comprehensive fashion, covering more of the surface area per motion.
Also, in any aspect of invention, it is preferable that the surface of the wand is hydrophobic.
Making the surface of the wand hydrophobic will encourage the formation of droplets on the wand, which will enhance the efficiency with which a large droplet can be formed at the end of the wand.
That the wand is hydrophobic will further encourage the travel of the droplets to the tip of the wand.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the chamber is cylindrical.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the chamber is tapered
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the chamber comprises a hydrophobic material.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein at least part of the inner surface of the sample collector comprises a hydrophobic material.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector and wherein the cooling means comprises a Peltier device.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a wand.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a tapered wand.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a resiliently deformable wand.
In another aspect, the invention comprises a breath condensate collector comprising a chamber having a breath inlet port and an outlet port; a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means to promote in use condensation of vapour from breath entering the sample collector; and a hydrophobic wand.
The invention will be illustrated by the accompanying drawings, in which:
In this embodiment, the inlet port 14 is furthest away from the sample collector, which is a partially lidded dish 110, while the outlet port 16 is near to the partially lidded dish 110. The chamber 12 fits frictionally inside the breath condensate collector 10. It may alternatively be held in place by supplementary attachment means. In this embodiment, the chamber 12 is removable.
In this embodiment, the entire inside of the chamber 12 is coated with a hydrophobic material. This may be a material of the polytetrafluoroethylene (PTFE) family such as Teflon™, made by E. I. du Pont de Nemours and Company of 1007 Market St. Wilmington, Del. 19898, USA, or comprise a siliconised surface or any other material or combination of materials known to the skilled man. The material may be part of the chamber 12 itself or the chamber 12 may be made from it. It may cover all or part of the inside of the chamber 12.
The chamber 12, may be partially or entirely transparent.
In this embodiment, the chamber 12 is reusable and it is made of plastics. It is so fashioned that it may be easily cleaned between uses. Reusable chambers may also be fashioned of stainless steel or composite materials. Alternatively, disposable cardboard or plastics chambers may be appropriate.
Returning to
The ideal placement of the partially lidded dish 110 in relation to the outlet port 18, is to have each facing the other, the outlet port 16 being so sized that condensate travelling down it will be directed into the partially lidded dish 110 and so placed so as to be substantially aligned with the aperture formed by the partial lid. In this embodiment there is a distance of about 2 mm between the outlet port 16 and the partial lid portion 124. Other placements are envisaged, but this is the optimal placement. If the outlet port 16, was inside the dish 110, the flow of air into the dish 110 would serve to dry any condensate collected, thus robbing it of at least part of its diagnostic value. If the outlet port 16 was further away from the partially lidded dish 110, there would be two problems. The first would be that of improperly directed condensate, which may at least be messy, and at most the possible carrier of infectious matter or otherwise dangerous. The second would be that the flow of air would be prone to making a whistling sound upon contact with the partially lidded dish 110. In embodiments where the collector is being used to collect condensate from an animal such as a horse, the whistling may startle or otherwise disconcert the horse, thus hampering the collection of condensate or endangering the people collecting it.
The collector 10 further features cooling means 112 to promote in use condensation of vapour from breath entering the collection condensate vessel. In this embodiment, said cooling means 112 comprises a Peltier device, having a cooling surface 114 and heat dissipating fins 116 of which six can be seen. The cooling surface 114 is so arranged as to be in operable communication with the partially lidded dish 110 on a flat or curved plane, and may follow the profile of the partially lidded dish 110.
The device is powered by conventional means (not shown), and is rechargeable. It may be attached to a power source via a recharge point 118 which in this embodiment is situated in a recess 120. The employment of a Peltier device 112 dispenses with the need for external cooling means, making it particularly useful for the travelling vet, or someone who is otherwise without separate refrigeration means. The Peltier device 112 is operated via an on/off switch 122, but may alternatively be operated by a switch actuated by the placement or removal of the lidded dish 110 in the recess (not shown).
In the alternative, other cooling means, such as a pre-cooled metallic element or a cooling jacket may be substituted.
This embodiment of the wand 60 has a deformation profile of such attributes that when, in use, force is applied to the wand 60 it deforms in such a way as to mimic the curvature of the chamber or sample collector of the device. This will enable the wand 60 to be used to scrape the condensate more quickly and effectively. Having got the condensate onto the wand 60, the provision of hydrophobic material encourages the condensate to form in beads on the wand 60. The taper will then encourage droplets on a wand 60 which is held so that the thin end is pointing substantially downwards to travel towards the tip.
Clearly the chamber 12 need not be detached from the device 10 in order for condensate to be collected.
It is possible to use the chamber 12 and wand 60 configuration on its own (i.e. without the sample collector) to collect condensate, and embodiments may therefore be envisaged comprising the chamber 12 and the wand 60.
Claims
1. A breath condensate collector comprising:
- a chamber having a breath inlet port and an outlet port;
- a sample collector comprising a partially lidded dish, adapted to receive breath from the chamber outlet and having air exhaust means;
- cooling means, in operable communication with said partially lidded dish, to promote, in use, condensation of vapour from breath entering the sample collector.
2. A breath condensate collector according to claim 1, wherein the chamber is cylindrical.
3. A breath condensate collector according to claim 1, where at least a part of the chamber is tapered
4. A breath condensate collector according to claim 1, wherein at least a part of the inner surface of the chamber comprises a hydrophobic material.
5. A breath condensate collector according to claim 1, wherein at least part of the inner surface of the sample collector comprises a hydrophobic material.
6. A breath condensate collector according to claim 1, wherein the cooling means comprises a Peltier device.
7. A breath condensate collector according to claim 1, further comprising a wand.
8. A breath condensate collector according to claim 7 wherein the wand is tapered.
9. A breath condensate collector according to claim 7 wherein the wand is resiliently deformable.
10. A breath condensate collector according to claim 7 wherein the surface of the wand is hydrophobic.
11. (canceled)
12. A breath condensate collector according to claim 1, in which said sample collector is spaced apart from the outlet port of said chamber, and said outlet port is aligned with the aperture formed by the partial lid.
Type: Application
Filed: Jun 6, 2008
Publication Date: Jul 29, 2010
Inventor: George Lee Bulbrook (Norfolk)
Application Number: 12/670,432
International Classification: A61B 5/097 (20060101);