Electromagnetically Actuated Intracorporeal Drug Delivery
In one embodiment, an elongate body with a proximal end and a distal end is disclosed and which is controllable by an operator at the proximal end; in one embodiment, the elongate body is a catheter and the catheter tip is located at the distal end. The body contains numerous magnets along its length, at least one of which is an electromagnet, controllable by means of a current delivered by the operator of the body at the proximal end of the body. The magnets are placed such that a force is created at the distal end of the elongate body. The magnetic forces which control the distal end of the body originate from the controllable magnets placed on the body.
This application is a continuation of application Ser. No. 11/424,226, now U.S. Pat. No. 7,712,470 which claims priority to provisional application Ser. No. 60/691,050 which is herein incorporated by reference in its entirety. It is also a continuation of non-provisional patent application Ser. No. 11/424,226 also incorporated by reference in its entirety.
SUMMARY OF INVENTIONDisclosed in this invention is an elongate body with a proximal end and a distal end and which is controllable by an operator at the proximal end; in one embodiment, the elongate body is a catheter and the catheter tip is located at the distal end. The body contains numerous magnets along its length, at least one of which is an electromagnet, controllable by means of a current delivered by the operator of the body at the proximal end of the body. The magnets are strategically placed such that a force is created at the distal end of the elongate body. The magnetic forces which control the distal end of the body originate from the controllable magnets (e.g. an electromagnet) placed on the body.
In some embodiments, the elongate body is a catheter for navigation within a patient. Torque is applied by the magnets on the body to the distal end for purposes of navigation within a patient.
In some embodiments, the elongate body is a surgical tool for use during an open or laparoscopic surgery.
In some embodiments, the magnets apply force to the distal end of the elongate body for purposes of applying a cyclic force to tissues. In some embodiments, the magnets are used to impart kinetic energy to particles. In some embodiments, the magnets are used to create a pressure head in a fluid in the catheter and the pressurized fluid is used to create changes in tissue when released from the catheter. In some embodiments, the fluid contains particles and in other embodiments, the fluid is heated or cooled.
The elongate body 50, in some embodiments, can be a catheter that is placed inside a patient. The distal end of the elongate body can be adapted to be placed through a sheath and into the blood vessels of a patient.
Alternatively, the elongate body can be adapted to be placed into the interstitial substance of a patient, such as, for example, to reach a tumor in the lung or to reach a deteriorating spinal disc. The elongate body in some embodiments can also transfer energy via X-ray, gamma ray, magnetic waves.
The controlled magnetic field or other energy fields which originate on the body allow for desired functionality of the elongate body 50, e.g. through manipulation of the distal end 10 of the body or (as described below) manipulation of actuators or particles on or in the elongate body. As an example, the direction of the elongate body can be controlled by activating the one or more magnets or electromagnets.
Electromagnets are controlled or activated by current whereas permanent magnets can be controlled through magnetic shielding, which when removed, allows the permanent magnets to interact with one another or with the electromagnets. Both activation with current and removal of shielding are included in the term “activation.”
The distance 120 of magnets 100 from the center axis of the elongate body at its cross-section is greater than the distance of material 200 from the center 210 of the elongate body at its respective cross-section; therefore, when magnet 100 is induced to attract or repel material 200 (see below), a torque T is created on the distal end of the elongate body. The torque T on the distal end of the elongate body, in turn, can induce a bend in the elongate body and can therefore be used for navigation purposes within the body of a patient (e.g. within the vascular system).
Elongate body 50 can be made from one or more of or any type of biocompatible material typically used in devices that enter blood vessels or other tissues; these materials include polyurethane, silicone, Dacron, polyester, or nitinol. In one embodiment, elongate body is made from a shape memory alloy such as nitinol, or a suitable polymer, so that after torque is applied to the body tip, the catheter and tip return to a neutral, in-line position.
Circuitry 300 integrates user inputs (e.g. a physician applying directional forces to a joystick) and sends proper signals to the electromagnet(s) 100 to enable actuation of the distal tip 10. Actuation of other or additional electromagnets enables varying directionality or functionality of the tip.
In another embodiment, a plurality of electromagnets 100 is disposed on the elongate body 50. The bulk material properties of the elongate body are controlled by creating different forces between the magnets on the catheter. For example, the stiffness or flexibility of the catheter can be controlled by activating or deactivating one or more magnets. Depending on the strength of the force between the magnets, the flexibility of the catheter can be varied between stiff and flexible.
Clinical ApplicationsThe clinical applications of this invention are diverse and vast. Point of use actuation and navigation from a narrow probe can be used in a variety of minimally invasive procedures, settings including catheter navigation, energy transfer from surgical devices (e.g. tissue ablation, coagulation), thrombus removal, to name a few.
Methods of ManufactureAny of the materials on the body including the magnets can be manufactured using techniques known to those skilled in the art. For example, the magnets can be glued to the body or they can be integrated into a circuit which is then glued to the body.
In another example, microfabrication techniques are used to deposit magnetic or magnetic elements on the body. In some embodiments, the magnetic elements are deposited on a board (e.g. circuit board) and then the board is fixed or glued to the catheter. The board may be composed of standard circuit board materials or the board can be manufactured from a polymer or a fabric. The microfabrication technologies available include electrodeposition (electroless and/or electroplating), vapor deposition (physical and chemical), lithography, soft-lithography, nano-imprint lithography, screen printing, and/or a variety of other methods known to those well-skilled in the arts (for example, see U.S. Pat. No. 6,281,560 incorporated into reference for this patent).
The arrangement of the proximal magnetic elements is crucial to the functionality of the device. If the magnetic elements are in-line with the distal element, then torque will not be generated. If the magnetic elements are not in-line with the distal elements, the torques will be generated.
In another embodiment, the substance of the body is produced with magnetic particles (e.g. magnetic nanoparticles) inside it. For example, in the case of a catheter, the catheter material is molded with particles within the polymeric material so that the magnetic force now attracts the polymeric material.
Functionality of the DeviceIn some embodiments, the distal tip is vibrated by on-off cycling of the electromagnet so that the tip moves at a high speed and can disrupt tissue such as neoplastic tissue, atherosclerotic tissue, ocular tissue, etc. The tip can vibrate in a direction longitudinal to the catheter or can vibrate in a direction perpendicular to the catheter.
In other embodiments, the controllable magnets can be used to accelerate particles, such as nanoparticles, into a vascular lesion, such as an atherosclerotic plaque, or into a lesion such as a tumor. Particle acceleration can occur for at least two reasons: 1) a repelling force relative to the particle or forcing the particle out the end of the catheter at a relatively high speed; 2) the magnets on the catheter act as an actuator to directly accelerate the particles via transfer of kinetic energy or by creating a pressure on the fluid containing the particles.
Claims
1. A method of treating a patient comprising:
- a. Advancing a device into a patient;
- b. Applying electrical current to a magnet attached to the device wherein the electrical current induces pressure formation within the device resulting in expulsion of particles of out the end of the device and into a tissue in the patient.
2. The method of claim 1 further comprising loading magnetic particles into the catheter.
3. The method of claim 1 further comprising advancing said device into a tumor in the patient.
4. The method of claim 1 further comprising advancing said device into the vasculature of the patient.
Type: Application
Filed: Apr 25, 2010
Publication Date: Aug 12, 2010
Inventor: Michael Gertner (Menlo Park, CA)
Application Number: 12/766,898
International Classification: A61M 25/01 (20060101);