TUBERCULOSIS BIOMARKERS AND USES THEREOF

The present invention provides biomarkers, methods and kits for diagnosing active tuberculosis in a subject, methods and kits for monitoring the effectiveness of treatment for active TB, as well as methods for identifying a compound that can treat TB reduce or inhibit the development of complications associated with the disease in a subject, and methods to treat active TB.

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Description
RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 14/835,939, filed on Aug. 26, 2015, which is a 35 U.S.C. 111(a) continuation application, which claims the benefit of priority to PCT/US2014/017289, filed on Feb. 20, 2014 and U.S. Provisional Patent Application Ser. No. 61/770,432, filed on Feb. 28, 2013, the entire contents of each of which is incorporated herein by reference.

BACKGROUND OF THE INVENTION

Tuberculosis (TB) remains a major global public health problem. About a third of the world's population is latently infected with Mycobacterium tuberculosis, and an estimated 8.7 million new TB cases were diagnosed in 2011 (World Health Organization, Global tuberculosis control: WHO report 2011, 2011: Geneva, Switzerland). In addition, in 2011 almost one million TB-associated deaths occurred among HIV uninfected (HIV−) individuals and about 0.43 million deaths among HIV-infected (HIV+) individuals.

In addition to prevention, the cornerstones of TB control are reduction of transmission, morbidity, and mortality all of which require early treatment initiation. This in turn necessitates timely TB diagnosis, underlining the need for new rapid diagnostic tests. Rapid identification of active TB is the key unmet need in TB disease management.

Currently, TB diagnostic tests depend on the detection of M. tuberculosis which, thus, require a specimen from the site of disease which is not always easy to obtain. Furthermore, the current tests for TB are limited by lack of sensitivity (microscopy of sputum smears) or require amplification of M. tuberculosis which takes weeks (culture) and/or is expensive (molecular detection). Moreover, these gold standard tests (culture and molecular detection) require laboratory infrastructure which is not accessible in many endemic regions.

Accordingly, there is a need in the art for novel TB biomarkers that are easily detectable, and neither require a specimen from the site of infection, nor laboratory infrastructure to provide rapid TB diagnosis and limit the spread of the disease.

SUMMARY OF THE INVENTION

The present invention is based, at least in part, on the discovery of markers that are associated with the presence of active tuberculosis (TB). Accordingly, the present invention provides sensitive and facile methods and kits for determining whether a subject has active TB, as well as methods for identifying a compound that can treat active TB, methods of monitoring the effectiveness of a therapy for treating active TB in a subject, and methods for treating a subject having active TB by measuring and identifying particular markers, or particular combinations of markers.

Accordingly, in one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of one or more markers listed in Table 1 in a sample(s) from the subject; comparing the level of the one or more markers in the subject sample(s) with a level of the one or more markers in a control sample(s), wherein a difference in the level of the one or more markers in the subject sample(s) as compared to the level of the one or more markers in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of one or more markers listed in Table 1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of one or more markers listed in Table 1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of the one or more markers in the first sample(s) with a level of the one or more markers in the second sample(s), wherein a difference in the level of the one or more markers in the first sample(s) as compared to the level of the one or more markers in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers listed in Table 1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the one or more markers listed in Table 1 in an aliquot as compared to the level and/or activity of the one or more markers of the invention in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the level and/or activity of any one or more of the markers listed in Table 1, thereby treating the subject.

In one embodiment, the subject is HIV positive (HIV+). In another embodiment, the subject is HIV negative (HIV−).

In one embodiment, the level of the marker is an expression level and/or activity of the marker.

In one embodiment, the level in the subject sample(s) is determined by mass spectrometry. In one embodiment, the mass spectrometry is matrix assisted laser desorption/time of flight (MALDI/TOF) mass spectrometry, liquid chromatography quadruple ion trap electrospray (LCQ-MS), or surface enhanced laser desorption ionization/time of flight (SELDI/TOF) mass spectrometry. In another embodiment, the level in the subject sample(s) is determined by immunoassay.

In one embodiment, the sample(s) from the subject is a fluid sample(s). In another embodiment, the sample(s) from the subject is a tissue sample(s).

In one embodiment, the subject resides in North America or Europe.

In one embodiment, the one or more markers is selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS.

In another embodiment, the methods further comprise determining the level of one or CPB2, GP1BA, GPS, GPX3, PROCR, VWF, ATRN, CD14, DBH, SELL, VCAM1, S100A8, S100A9, CD163, CPN1, FCN3, HIST2H2BE, KNG1, MASP1, MASP2, PROS1, YWHAZ, CA1, ORM1, PDLIM1, PGLYRP2, LCAT, LPA, PCSK9, PON1, PTGDS, APOA1, APOA4, APOC1, APOC3, APOE, ANPEP, BCHE, BTD, CDHS, CLEC3B, CLU, CNTN1, ECM1, GPLD1, HABP2, HGFAC, HYOU1, IGFALS, IGFBP3, IGFBP6, LCP1, LGALS3BP, LUM, MINPP1, MST1, NCAM1, NID1, PEPD, PFN1, PRG4, QSOX1, SEPP1, SHBG, SPARC, TGFBI, THBS1, TLN1, TNXB, VASN, VTN, YWHAE, CA2, CKM, CNDP1, COMP, IGF2, LRG1, PI16, PRDX2, PTPRG, SPP2, TAGLN2, ZYX, MTB81, MTB51, CACNA2D1, CPN2, and MAN1A1.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14 and the level of APOE in a sample(s) from the subject; comparing the level of CD14 and the level of APOE in the subject sample(s) with a level of CD14 and a level of APOE in a control sample(s), wherein a difference in the level of CD14 and a difference in the level of APOE in the subject sample(s) as compared to the level of CD14 and the level of APOE in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14 and the level of APOE in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14 and the level of APOE in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14 and the level of APOE in the first sample(s) with a level of CD14 and the level of APOE in the second sample(s), wherein a difference in the level of CD14 and a difference in the level of APOE in the first sample(s) as compared to the level of the CD14 and the level of APOE in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14 and the level and/or activity of APOE in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14 and the level and/or activity of APOE in an aliquot as compared to the level and/or activity of CD14 and the level and/or activity of APOE in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the level and/or activity of CD14 and the level and/or activity of APOE, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD and the level of SELL in a sample(s) from the subject; comparing the level of PEPD and the level of SELL in the subject sample(s) with a level of PEPD and a level of SELL in a control sample(s), wherein a difference in the level of PEPD and a difference in the level of SELL in the subject sample(s) as compared to the level of PEPD and the level of SELL in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD and the level of SELL in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD and the level of SELL in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD and the level of SELL in the first sample(s) with a level of PEPD and the level of SELL in the second sample(s), wherein a difference in the level of PEPD and the level of SELL in the first sample(s) as compared to the level of PEPD and the level of SELL in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD and the level and/or activity of SELL in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD and the level and/or activity of SELL in an aliquot as compared to the level and/or activity of PEPD and the level and/or activity of SELL of the invention in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD and the level and/or activity of SELL, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of TNXB in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of TNXB in the subject sample(s) with a level of PEPD, a level of SELL, and a level of TNXB in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of TNXB in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of TNXB in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of TNXB in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of TNXB in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) with a level of PEPD, the level of SELL, and the level of TNXB in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of COMP in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of COMP in the subject sample(s) with a level of PEPD, a level of SELL, and a level of COMP in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of COMP in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of COMP in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of COMP in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of COMP in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of COMP in the first sample(s) with a level of PEPD, the level of SELL, and the level of COMP in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of COMP in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of COMP in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of COMP in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of COMP in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of COMP in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of COMP, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of CD14 in the subject sample(s) with a level of PEPD, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) with a level of PEPD, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of PEPD, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of LUM in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of LUM in the subject sample(s) with a level of PEPD, a level of SELL, and a level of LUM in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of LUM in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of LUM in the first sample(s) with a level of PEPD, the level of SELL, and the level of LUM in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of LUM in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of TNXB, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of TNXB, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of TNXB, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of TNXB, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of TNXB, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of TNXB, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of APOC1, the level and/or activity of SELL, and the level and/or activity of QSOX1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of TNXB, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of TNXB, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of TNXB, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of TNXB, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of TNXB, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of TNXB, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of COMP, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of COMP, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of COMP, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of COMP, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of COMP, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of COMP, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of LUM, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of LUM, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of LUM, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of LUM, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of LUM, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of LUM, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of QSOX1, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of QSOX1, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of QSOX1, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of QSOX1, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of QSOX1, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of QSOX1, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of QSOX1, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of QSOX1, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of QSOX1, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of QSOX1, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of QSOX1, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of QSOX1, the level and/or activity of SELL, and the level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of QSOX1, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of QSOX1, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of QSOX1, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of APOC1, and the level of CD14 in a sample(s) from the subject; comparing the level of PEPD, the level of APOC1, and the level of CD14 in the subject sample(s) with a level of PEPD, a level of APOC1, and a level of CD14 in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of APOC1, and a difference in the level of CD14 in the subject sample(s) as compared to the level of PEPD, the level of APOC1, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of APOC1, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of APOC1, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of APOC1, and the level of CD14 in the first sample(s) with a level of PEPD, the level of APOC1, and the level of CD14 in the second sample(s), wherein a difference in the level of PEPD, the level of APOC1, and the level of CD14 in the first sample(s) as compared to the level of PEPD, the level of APOC1, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of APOC1, and the level and/or activity of CD14 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of APOC1, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of APOC1, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of APOC1, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of SELL, and the level of APOC1 in the first sample(s) with a level of COMP, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of APOC1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of QSOX1, the level of APOC1, and the level of CD14 in a sample(s) from the subject; comparing the level of QSOX1, the level of APOC1, and the level of CD14 in the subject sample(s) with a level of QSOX1, a level of APOC1, and a level of CD14 in a control sample(s), wherein a difference in the level of QSOX1, a difference in the level of APOC1, and a difference in the level of CD14 in the subject sample(s) as compared to the level of QSOX1, the level of APOC1, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of QSOX1, the level of APOC1, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of QSOX1, the level of APOC1, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of QSOX1, the level of APOC1, and the level of CD14 in the first sample(s) with a level of QSOX1, the level of APOC1, and the level of CD14 in the second sample(s), wherein a difference in the level of QSOX1, the level of APOC1, and the level of CD14 in the first sample(s) as compared to the level of QSOX1, the level of APOC1, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of QSOX1, the level and/or activity of APOC1, and the level and/or activity of CD14 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of QSOX1, the level and/or activity of APOC1, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of QSOX1, the level and/or activity of APOC1, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of QSOX1, the level and/or activity of APOC1, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of PEPD, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of PEPD, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of PEPD, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PEPD, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PEPD, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) with a level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, and the level of SELL in a sample(s) from the subject; comparing the level of CD14, the level of APOE, and the level of SELL in the subject sample(s) with a level of CD14, a level of APOE, and a level of SELL in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, and a difference in the level of SELL in the subject sample(s) as compared to the level of CD14, the level of APOE, and the level of SELL in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level CD14, the level of APOE, and the level of SELL in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, and the level of SELL in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of the CD14, the level of APOE, and the level of SELL with a level of CD14, the level of APOE, and the level of SELL in the second sample(s), wherein a difference in the level of CD14, the level of APOE, and the level of SELL in the first sample(s) as compared to the level of CD14, the level of APOE, and the level of SELL in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, and the level and/or activity of SELL of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level of APOE, and the level of SELL in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, and the level and/or activity of SELL in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the level and/or activity of CD14, the level and/or activity of APOE, and the level and/or activity of SELL, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in a sample(s) from the subject; comparing the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in the subject sample(s) with a level of GP1BA, a level of PEPD, a level of SELL, and a level of TNXB in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of TNXB in the subject sample(s) as compared to the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) with a level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s), wherein a difference in the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) as compared to the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of TNXB in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of TNXB in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of LUM in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of LUM in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of LUM in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in a sample(s) from the subject; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in the subject sample(s) with a level of CD14, a level of PEPD, a level of SELL, and a level of TNXB in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of TNXB in the subject sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) with a level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s), wherein a difference in the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in the first sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of TNXB, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of PEPD, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of CD14, a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of GP1BA in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of GP1BA in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in a sample(s) from the subject; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in the subject sample(s) with a level of TNXB, a level of PEPD, a level of SELL, and a level of LUM in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of LUM in the subject sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in the first sample(s) with a level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in the second sample(s), wherein a difference in the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in the first sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of CD14, a level of PEPD, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) with a level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of CD14, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of TNXB, a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of LUM, a level of PEPD, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in the subject sample(s) with a level of COMP, a level of PEPD, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) with a level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of COMP, the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of TNXB, a level of PEPD, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of PEPD, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of TNXB, a level of PEPD, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) with a level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of TNXB, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of QSOX1, a level of PEPD, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of QSOX1, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of QSOX1, the level of PEPD, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of QSOX1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of QSOX1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of QSOX1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in the subject sample(s) with a level of LUM, a level of PEPD, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) with a level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of LUM, a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of COMP, a level of APOC1, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of APOC1, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of COMP, the level of APOC1, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of APOC1, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of APOC1, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of APOC1, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of GP1BA, a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of LUM, a level of PEPD, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) with a level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of PEPD, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of SEPP1, a level of PEPD, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) with a level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of SEPP1, the level of PEPD, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of COMP, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of CD14, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of SEPP1, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of SEPP1, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of SEPP1, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of SEPP1, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of SEPP1, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of SEPP1, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of LUM, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of LUM, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of GP1BA, a level of CD14, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of CD14, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of GP1BA, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in a sample(s) from the subject; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in the subject sample(s) with a level of LUM, a level of PEPD, a level of SELL, and a level of GP1BA in a control sample(s), wherein a difference in the level of LUM, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of GP1BA in the subject sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) with a level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s), wherein a difference in the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) as compared to the level of LUM, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of TNXB, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of TNXB, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in a sample(s) from the subject; comparing the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in the subject sample(s) with a level of SEPP1, a level of PEPD, a level of SELL, and a level of GP1BA in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of GP1BA in the subject sample(s) as compared to the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) with a level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s), wherein a difference in the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) as compared to the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of SEPP1, a level of TNXB, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of SEPP1, a level of LUM, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in a sample(s) from the subject; comparing the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in the subject sample(s) with a level of SEPP1, a level of COMP, a level of SELL, and a level of GP1BA in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of GP1BA in the subject sample(s) as compared to the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in the first sample(s) with a level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in the second sample(s), wherein a difference in the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in the first sample(s) as compared to the level of SEPP1, the level of COMP, the level of SELL, and the level of GP1BA in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of GP1BA in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of GP1BA in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of GP1BA, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in a sample(s) from the subject; comparing the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in the subject sample(s) with a level of APOC1, a level of PEPD, a level of SELL, and a level of GP1BA in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of PEPD, a difference in the level of SELL, and a difference in the level of GP1BA in the subject sample(s) as compared to the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) with a level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s), wherein a difference in the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in the first sample(s) as compared to the level of APOC1, the level of PEPD, the level of SELL, and the level of GP1BA in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of PEPD, the level and/or activity of SELL, and the level and/or activity of GP1BA, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of SEPP1, a level of COMP, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of SEPP1, the level of COMP, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in a sample(s) from the subject; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in the subject sample(s) with a level of SEPP1, a level of LUM, a level of SELL, and a level of COMP in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of COMP in the subject sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in the first sample(s) with a level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in the second sample(s), wherein a difference in the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in the first sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of COMP in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of COMP in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of COMP in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of COMP, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of SEPP1, a level of CD14, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of CD14, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of SEPP1, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in a sample(s) from the subject; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in the subject sample(s) with a level of SEPP1, a level of TNXB, a level of SELL, and a level of COMP in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of COMP in the subject sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in the first sample(s) with a level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in the second sample(s), wherein a difference in the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in the first sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of COMP in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of COMP in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of COMP in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of COMP, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of CD14, a level of GP1BA, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of TNXB, a level of CD14, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of CD14, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of TNXB, the level of CD14, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of SEPP1, a level of TNXB, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in the first sample(s) with a level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in a sample(s) from the subject; comparing the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in the subject sample(s) with a level of APOC1, a level of SELL, a level of GP1BA, and a level of QSOX1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of SELL, a difference in the level of GP1BA, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in the first sample(s) with a level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in the second sample(s), wherein a difference in the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in the first sample(s) as compared to the level of APOC1, the level of SELL, the level of GP1BA, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of SELL, the level and/or activity of GP1BA, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of SELL, the level and/or activity of GP1BA, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of SELL, the level and/or activity of GP1BA, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in the subject sample(s) with a level of APOC1, a level of CD14, a level of GP1BA, and a level of PEPD in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of PEPD in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in the first sample(s) with a level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of PEPD in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of PEPD in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of PEPD in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of PEPD, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in a sample(s) from the subject; comparing the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in the subject sample(s) with a level of COMP, a level of CD14, a level of GP1BA, and a level of SELL in a control sample(s), wherein a difference in the level of COMP, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of SELL in the subject sample(s) as compared to the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in the first sample(s) with a level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in the second sample(s), wherein a difference in the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in the first sample(s) as compared to the level of COMP, the level of CD14, the level of GP1BA, and the level of SELL in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of SELL in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of SELL in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of SELL, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in the subject sample(s) with a level of APOC1, a level of CD14, a level of GP1BA, and a level of TNXB in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of TNXB in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in the first sample(s) with a level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of TNXB in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of TNXB in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of TNXB, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in the subject sample(s) with a level of APOC1, a level of CD14, a level of GP1BA, and a level of COMP in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of COMP in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in the first sample(s) with a level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of COMP in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of COMP in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of COMP in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of COMP, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of TNXB, a level of COMP, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of TNXB, the level of COMP, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of TNXB, a level of GP1BA, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of GP1BA, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of TNXB, the level of GP1BA, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of TNXB, a level of LUM, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of TNXB, the level of LUM, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of SEPP1, a level of GP1BA, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of GP1BA, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of SEPP1, the level of GP1BA, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of SEPP1, a level of LUM, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in the first sample(s) with a level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in the subject sample(s) with a level of APOC1, a level of CD14, a level of GP1BA, and a level of LUM in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of LUM in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in the first sample(s) with a level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of TNXB, a level of GP1BA, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of GP1BA, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in the subject sample(s) with a level of SEPP1, a level of LUM, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in the first sample(s) with a level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of SEPP1, the level of LUM, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in the subject sample(s) with a level of TNXB, a level of COMP, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in the first sample(s) with a level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of TNXB, the level of COMP, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in the subject sample(s) with a level of SEPP1, a level of TNXB, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) with a level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of SEPP1, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of LUM, a level of GP1BA, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of GP1BA, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of LUM, the level of GP1BA, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in the subject sample(s) with a level of SEPP1, a level of COMP, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of COMP, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in the first sample(s) with a level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of SEPP1, the level of COMP, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of COMP, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in a sample(s) from the subject; comparing the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in the subject sample(s) with a level of LUM, a level of TNXB, a level of SELL, and a level of SEPP1 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in the first sample(s) with a level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in the second sample(s), wherein a difference in the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in the first sample(s) as compared to the level of LUM, the level of TNXB, the level of SELL, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in the subject sample(s) with a level of APOC1, a level of TNXB, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) with a level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of APOC1, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of TNXB, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in the subject sample(s) with a level of APOC1, a level of CD14, a level of GP1BA, and a level of SEPP1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of GP1BA, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in the first sample(s) with a level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of GP1BA, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in the subject sample(s) with a level of APOC1, a level of CD14, a level of SELL, and a level of LUM in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of SELL, and a difference in the level of LUM in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in the first sample(s) with a level of APOC1, the level of CD14, the level of SELL, and the level of LUM in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of GP1BA, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of GP1BA, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in the first sample(s) with a level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of GP1BA, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of GP1BA, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of CD14, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of CD14, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in the first sample(s) with a level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of CD14, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of CD14, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in the subject sample(s) with a level of APOC1, a level of CD14, a level of PEPD, and a level of LUM in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of PEPD, and a difference in the level of LUM in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in the first sample(s) with a level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of PEPD, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in a sample(s) from the subject; comparing the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in the subject sample(s) with a level of LUM, a level of TNXB, a level of SELL, and a level of COMP in a control sample(s), wherein a difference in the level of LUM, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of COMP in the subject sample(s) as compared to the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in the first sample(s) with a level of LUM, the level of TNXB, the level of SELL, and the level of COMP in the second sample(s), wherein a difference in the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in the first sample(s) as compared to the level of LUM, the level of TNXB, the level of SELL, and the level of COMP in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of COMP in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of COMP in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of COMP, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of SEPP1, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of SEPP1, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in the subject sample(s) with a level of LUM, a level of TNXB, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of LUM, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) with a level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of LUM, the level of TNXB, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LUM, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of LUM, a level of SELL, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of LUM, the level of SELL, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of LUM, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of LUM, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in the first sample(s) with a level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of LUM, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of LUM, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of TNXB, a level of SELL, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in the first sample(s) with a level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of TNXB, the level of SELL, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of SEPP1, a level of COMP, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of SEPP1, a difference in the level of COMP, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of COMP, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of COMP, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of COMP, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of COMP, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of SEPP1, a level of LUM, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of SEPP1, a difference in the level of LUM, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of LUM, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of LUM, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of LUM, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of LUM, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in a sample(s) from the subject; comparing the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in the subject sample(s) with a level of GP1BA, a level of SEPP1, a level of TNXB, and a level of CD14 in a control sample(s), wherein a difference in the level of GP1BA, a difference in the level of SEPP1, a difference in the level of TNXB, and a difference in the level of CD14 in the subject sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in the first sample(s) with a level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in the second sample(s), wherein a difference in the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in the first sample(s) as compared to the level of GP1BA, the level of SEPP1, the level of TNXB, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of TNXB, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of TNXB, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of GP1BA, the level and/or activity of SEPP1, the level and/or activity of TNXB, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in the subject sample(s) with a level of APOC1, a level of CD14, a level of QSOX1, and a level of SEPP1 in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of QSOX1, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in the first sample(s) with a level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of QSOX1, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of QSOX1, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of QSOX1, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in a sample(s) from the subject; comparing the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in the subject sample(s) with a level of COMP, a level of CD14, a level of PEPD, and a level of APOC1 in a control sample(s), wherein a difference in the level of COMP, a difference in the level of CD14, a difference in the level of PEPD, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in the first sample(s) with a level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in the second sample(s), wherein a difference in the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in the first sample(s) as compared to the level of COMP, the level of CD14, the level of PEPD, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in a sample(s) from the subject; comparing the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in the subject sample(s) with a level of COMP, a level of TNXB, a level of SELL, and a level of GP1BA in a control sample(s), wherein a difference in the level of COMP, a difference in the level of TNXB, a difference in the level of SELL, and a difference in the level of GP1BA in the subject sample(s) as compared to the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in the first sample(s) with a level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in the second sample(s), wherein a difference in the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in the first sample(s) as compared to the level of COMP, the level of TNXB, the level of SELL, and the level of GP1BA in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of COMP, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of GP1BA in an aliquot as compared to the level and/or activity of COMP, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of GP1BA in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of COMP, the level and/or activity of TNXB, the level and/or activity of SELL, and the level and/or activity of GP1BA, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in a sample(s) from the subject; comparing the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in the subject sample(s) with a level of APOC1, a level of CD14, a level of QSOX1, and a level of LUM in a control sample(s), wherein a difference in the level of APOC1, a difference in the level of CD14, a difference in the level of QSOX1, and a difference in the level of LUM in the subject sample(s) as compared to the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in the first sample(s) with a level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in the second sample(s), wherein a difference in the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in the first sample(s) as compared to the level of APOC1, the level of CD14, the level of QSOX1, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of APOC1, the level and/or activity of CD14, the level and/or activity of QSOX1, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of QSOX1, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of APOC1, the level and/or activity of CD14, the level and/or activity of QSOX1, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in a sample(s) from the subject; comparing the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in the subject sample(s) with a level of TNXB, a level of CD14, a level of PEPD, and a level of APOC1 in a control sample(s), wherein a difference in the level of TNXB, a difference in the level of CD14, a difference in the level of PEPD, and a difference in the level of APOC1 in the subject sample(s) as compared to the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in the first sample(s) with a level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in the second sample(s), wherein a difference in the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in the first sample(s) as compared to the level of TNXB, the level of CD14, the level of PEPD, and the level of APOC1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of TNXB, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of APOC1 in an aliquot as compared to the level and/or activity of TNXB, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of APOC1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TNXB, the level and/or activity of CD14, the level and/or activity of PEPD, and the level and/or activity of APOC1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of TNXB in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of TNXB in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of TNXB in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of TNXB in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of TNXB in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of TNXB in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of TNXB, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of COMP in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of COMP in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of COMP in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of COMP in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of COMP in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of COMP in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of COMP in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of COMP in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of COMP in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of COMP in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of COMP in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of COMP in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of COMP in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of COMP in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of COMP, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of LUM in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of LUM in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of LUM in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of LUM in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of LUM in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of LUM in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of LUM in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of LUM in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of LUM in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of LUM in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of LUM in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LUM in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LUM in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LUM in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LUM, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of HABP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of HABP2 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of HABP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of HABP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of HABP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of HABP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of LRG1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of LRG1 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LRG1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LRG1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LRG1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of LRG1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of QSOX1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of QSOX1 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of QSOX1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of QSOX1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity CD14, the level and/or activity of APOE, the level and/or activity of SELL, and the level and/or activity of QSOX1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in the subject sample(s) with a level of CD14, a level of APOE, a level of SELL, and a level of S100A8 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of SELL, and a difference in the level of S100A8 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in the first sample(s) with a level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level level and/or activity of APOE, the level level and/or activity of SELL, and the level level and/or activity of S100A8 in an aliquot as compared to the level and/or activity of CD14, the level level and/or activity of APOE, the level level and/or activity of SELL, and the level level and/or activity of S100A8 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level level and/or activity of APOE, the level level and/or activity of SELL, and the level level and/or activity of S100A8, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, and the level of APOC3 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, and the level of APOC3 in the subject sample(s) with a level of CD14, a level of APOE, and a level of APOC3 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, and a difference in the level of APOC3 in the subject sample(s) as compared to the level of CD14, the level of APOE, and the level of APOC3 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, and the level of APOC3 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, and the level of APOC3 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, and the level of APOC3 in the first sample(s) with a level of CD14, the level of APOE, and the level of APOC3 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, and the level of APOC3 in the first sample(s) as compared to the level of CD14, the level of APOE, and the level of APOC3 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, and the level and/or activity of APOC3 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of APOE, and the level and/or activity of APOC3 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, and the level and/or activity of APOC3 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, and the level and/or activity of APOC3, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of APOE, a level of APOC3, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of APOC3, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in the subject sample(s) with a level of CD14, a level of APOE, a level of APOC3, and a level of SELL in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of APOC3, and a difference in the level of SELL in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in the first sample(s) with a level of CD14, the level of APOE, the level of APOC3, and the level of SELL in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in the first sample(s) as compared to the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of SELL in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of SELL in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of SELL, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in a sample(s) from the subject; comparing the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in the subject sample(s) with a level of CD14, a level of APOE, a level of APOC3, and a level of HABP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of APOE, a difference in the level of APOC3, and a difference in the level of HABP2 in the subject sample(s) as compared to the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in the first sample(s) with a level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in the second sample(s), wherein a difference in the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in the first sample(s) as compared to the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of one or more markers of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of HABP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of HABP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of APOE, the level and/or activity of APOC3, and the level and/or activity of HABP2, thereby treating the subject.

In one embodiment, the subject is HIV−.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1 and the level of PFN1 in a sample(s) from the subject; comparing the level of LCP1 and the level of PFN1 in the subject sample(s) with a level of LCP1 and a level of PFN1 in a control sample(s), wherein a difference in the level of LCP1 and a difference in the level of PFN1 in the subject sample(s) as compared to the level of LCP1 and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1 and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1 and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1 and the level of PFN1 in the first sample(s) with a level of LCP1 and the level of PFN1 in the second sample(s), wherein a difference in the level of LCP1 and the level of PFN1 in the first sample(s) as compared to the level of LCP1 and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1 and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1 and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of LCP1 and the level and/or activity of PFN1 of the invention in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1 and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1 and the level of VASN in a sample(s) from the subject; comparing the level of LCP1 and the level of VASN in the subject sample(s) with a level of LCP1 and a level of VASN in a control sample(s), wherein a difference in the level of LCP1 and a difference in the level of VASN in the subject sample(s) as compared to the level of LCP1 and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1 and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1 and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1 and the level of VASN in the first sample(s) with a level of LCP1 and the level of VASN in the second sample(s), wherein a difference in the level of LCP1 and the level of VASN in the first sample(s) as compared to the level of LCP1 and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1 and the level and/or activity of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1 and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of LCP1 and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1 and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of VASN and the level of PFN1 in a sample(s) from the subject; comparing the level of VASN and the level of PFN1 in the subject sample(s) with a level of VASN and a level of PFN1 in a control sample(s), wherein a difference in the level of VASN and a difference in the level of PFN1 in the subject sample(s) as compared to the level of VASN and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of VASN and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of VASN and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of VASN and the level of PFN1 in the first sample(s) with a level of VASN and the level of PFN1 in the second sample(s), wherein a difference in the level of VASN and the level of PFN1 in the first sample(s) as compared to the level of VASN and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of VASN and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of VASN and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of VASN and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of VASN and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, and the level of PFN1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, and the level of PFN1 in the subject sample(s) with a level of LCP1, a level of VASN, and a level of PFN1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, and the level of PFN1 in the first sample(s) with a level of LCP1, the level of VASN, and the level of PFN1 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, and the level of PFN1 in the first sample(s) as compared to the level of LCP1, the level of VASN, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, and the level of PFN1 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, and the level of PFN1 in the subject sample(s) with a level of CD14, a level of CPN2, and a level of PFN1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of CD14, the level of CPN2, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, and the level of PFN1 in the first sample(s) with a level of CD14, the level of CPN2, and the level of PFN1 in the second sample(s), wherein a difference in the level of CD14, the level of CPN2, and the level of PFN1 in the first sample(s) as compared to the level of CD14, the level of CPN2, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of CPN2, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of CPN2, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of CPN2, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of CD14, the level of CPN2, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of CPN2, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of CPN2, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PGLYRP2, and the level of PFN1 in a sample(s) from the subject; comparing the level of CD14, the level of PGLYRP2, and the level of PFN1 in the subject sample(s) with a level of CD14, a level of PGLYRP2, and a level of PFN1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PGLYRP2, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of CD14, the level of PGLYRP2, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PGLYRP2, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PGLYRP2, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PGLYRP2, and the level of PFN1 in the first sample(s) with a level of CD14, the level of PGLYRP2, and the level of PFN1 in the second sample(s), wherein a difference in the level of CD14, the level of PGLYRP2, and the level of PFN1 in the first sample(s) as compared to the level of CD14, the level of PGLYRP2, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, and the level of IGFBP6 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, and the level of IGFBP6 in the subject sample(s) with a level of CD14, a level of CPN2, and a level of IGFBP6 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, and a difference in the level of IGFBP6 in the subject sample(s) as compared to the level of CD14, the level of CPN2, and the level of IGFBP6 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, and the level of IGFBP6 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, and the level of IGFBP6 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, and the level of IGFBP6 in the first sample(s) with a level of CD14, the level of CPN2, and the level of IGFBP6 in the second sample(s), wherein a difference in the level of CD14, the level of CPN2, and the level of IGFBP6 in the first sample(s) as compared to the level of CD14, the level of CPN2, and the level of IGFBP6 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of IGFBP6 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of CPN2, and the level and/or activity of IGFBP6 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of IGFBP6 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, and the level and/or activity of IGFBP6, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of PGLYRP2, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PGLYRP2, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of PGLYRP2, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of PGLYRP2, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of VASN, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of VASN, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of VASN, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of VASN, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of VASN, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of VASN, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of VASN, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of VASN, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of VASN, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of CD14, the level of VASN, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of VASN, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level and/or activity of VASN, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of CD14, the level and/or activity of VASN, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of VASN, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of VASN, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the subject sample(s) with a level of VASN, a level of PGLYRP2, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of VASN, a difference in the level of PGLYRP2, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the first sample(s) with a level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the first sample(s) as compared to the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of VASN, the level of PGLYRP2, and the level of PFN1 in a sample(s) from the subject; comparing the level of VASN, the level of PGLYRP2, and the level of PFN1 in the subject sample(s) with a level of VASN, a level of PGLYRP2, and a level of PFN1 in a control sample(s), wherein a difference in the level of VASN, a difference in the level of PGLYRP2, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of VASN, the level of PGLYRP2, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of VASN, the level of PGLYRP2, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of VASN, the level of PGLYRP2, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of VASN, the level of PGLYRP2, and the level of PFN1 in the first sample(s) with a level of VASN, the level of PGLYRP2, and the level of PFN1 in the second sample(s), wherein a difference in the level of VASN, the level of PGLYRP2, and the level of PFN1 in the first sample(s) as compared to the level of VASN, the level of PGLYRP2, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of PFN1, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of PFN1, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of IGFBP6, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of IGFBP6, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in the subject sample(s) with a level of CD14, a level of CPN2, a level of PFN1, and a level of IGFBP6 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of PFN1, and a difference in the level of IGFBP6 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in the first sample(s) with a level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of IGFBP6 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of IGFBP6 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of IGFBP6, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of PFN1, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of PFN1, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of TAGLN2, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of TAGLN2, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of TAGLN2, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of CPN2, a level of PFN1, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of PFN1, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in the subject sample(s) with a level of CD14, a level of CPN2, a level of PFN1, and a level of VASN in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of PFN1, and a difference in the level of VASN in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in the first sample(s) with a level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of PFN1, and the level of VASN in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of PFN1, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of PFN1, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of VASN, a level of IGFBP6, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of VASN, a difference in the level of IGFBP6, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in the second sample(s), wherein a difference in the level CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of VASN, the level of IGFBP6, and the level of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of VASN, the level and/or activity of IGFBP6, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of VASN, the level and/or activity of IGFBP6, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of VASN, the level and/or activity of IGFBP6, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of SEPP1, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of SEPP1, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in the first sample(s) with a level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of SEPP1, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of SEPP1, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of SEPP1, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in the subject sample(s) with a level of CD14, a level of CPN2, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of TAGLN2, and a difference in the level of VASN in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in the first sample(s) with a level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of TAGLN2, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in a sample(s) from the subject; comparing the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in the subject sample(s) with a level of PGLYRP2, a level of CPN2, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of PGLYRP2, a difference in the level of CPN2, a difference in the level of TAGLN2, and a difference in the level of VASN in the subject sample(s) as compared to the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in the first sample(s) with a level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in the second sample(s), wherein a difference in the level PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in the first sample(s) as compared to the level of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PGLYRP2, the level of CPN2, the level of TAGLN2, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the PGLYRP2, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of PGLYRP2, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PGLYRP2, the level and/or activity of CPN2, the level and/or activity of TAGLN2, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in a sample(s) from the subject; comparing the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in the subject sample(s) with a level of CD14, a level of VASN, a level of IGFBP6, and a level of PFN1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of VASN, a difference in the level of IGFBP6, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in the first sample(s) with a level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in the second sample(s), wherein a difference in the level CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in the first sample(s) as compared to the level of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of VASN, the level of IGFBP6, and the level of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of VASN, the level and/or activity of IGFBP6, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of VASN, the level and/or activity of IGFBP6, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of VASN, the level and/or activity of IGFBP6, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of IGFBP6, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of IGFBP6, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of PFN1, a level of IGFBP6, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PFN1, a difference in the level of IGFBP6, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of PFN1, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PFN1, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of TAGLN2, a level of IGFBP6, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of IGFBP6, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of CPN2, a level of IGFBP6, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of IGFBP6, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of PFN1, a level of IGFBP6, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PFN1, a difference in the level of IGFBP6, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the second sample(s), wherein a difference in the level CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in the subject sample(s) with a level of CD14, a level of CPN2, a level of IGFBP6, and a level of VASN in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of IGFBP6, and a difference in the level of VASN in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in the first sample(s) with a level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of IGFBP6, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of IGFBP6, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, the level of TAGLN2, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, the level of TAGLN2, a level of PFN1, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of PFN1, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of PFN1, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of PFN1, a level of IGFBP6, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of PFN1, a difference in the level of IGFBP6, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the second sample(s), wherein a difference in the level CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in the subject sample(s) with a level of CD14, the level of TAGLN2, a level of PFN1, and a level of VASN in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of PFN1, and a difference in the level of VASN in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in the first sample(s) with a level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of PFN1, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of PFN1, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of PFN1, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of PFN1, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of TAGLN2, a level of IGFBP6, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of IGFBP6, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of IGFBP6, a level of PFN1, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of IGFBP6, a difference in the level of PFN1, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of IGFBP6, the level of PFN1, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the IGFBP6, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of IGFBP6, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of IGFBP6, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of CPN2, a level of PFN1, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CPN2, a difference in the level of PFN1, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CPN2, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CPN2, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CPN2, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in the subject sample(s) with a level of CD14, a level of TAGLN2, a level of PGLYBP2, and a level of SEPP1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of PGLYBP2, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in the first sample(s) with a level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of PGLYBP2, and the level of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of PGLYBP2, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of PGLYBP2, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of PGLYBP2, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the subject sample(s) with a level of CPN2, a level of PFN1, a level of IGFBP6, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CPN2, a difference in the level of PFN1, a difference in the level of IGFBP6, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) with a level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) as compared to the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CPN2, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CPN2, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CPN2, the level and/or activity of PFN1, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in a sample(s) from the subject; comparing the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in the subject sample(s) with a level of CD14, a level of TAGLN2, a level of IGFBP6, and a level of PFN1 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of TAGLN2, a difference in the level of IGFBP6, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in the first sample(s) with a level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in the second sample(s), wherein a difference in the level CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in the first sample(s) as compared to the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in the subject sample(s) with a level of CPN2, a level of PFN1, a level of TAGLN2, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CPN2, a difference in the level of PFN1, a difference in the level of TAGLN2, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in the first sample(s) with a level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in the first sample(s) as compared to the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CPN2, the level and/or activity of PFN1, the level and/or activity of TAGLN2, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CPN2, the level and/or activity of PFN1, the level and/or activity of TAGLN2, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CPN2, the level and/or activity of PFN1, the level and/or activity of TAGLN2, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in a sample(s) from the subject; comparing the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in the subject sample(s) with a level of CD14, the level of SEPP1, a level of PFN1, and a level of VASN in a control sample(s), wherein a difference in the level of CD14, a difference in the level of SEPP1, a difference in the level of PFN1, and a difference in the level of VASN in the subject sample(s) as compared to the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in the first sample(s) with a level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in the second sample(s), wherein a difference in the level CD14, the level of SEPP1, the level of PFN1, and the level of VASN in the first sample(s) as compared to the level of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of SEPP1, the level of PFN1, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of SEPP1, the level and/or activity of PFN1, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of SEPP1, the level and/or activity of PFN1, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of SEPP1, the level and/or activity of PFN1, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in a sample(s) from the subject; comparing the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in the subject sample(s) with a level of CD14, the level of SEPP1, a level of TAGLN2, and a level of VASN in a control sample(s), wherein a difference in the level of CD14, a difference in the level of SEPP1, a difference in the level of TAGLN2, and a difference in the level of VASN in the subject sample(s) as compared to the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in the first sample(s) with a level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in the second sample(s), wherein a difference in the level CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in the first sample(s) as compared to the level of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of SEPP1, the level of TAGLN2, and the level of VASN in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of SEPP1, the level and/or activity of TAGLN2, and the level and/or activity of VASN in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of SEPP1, the level and/or activity of TAGLN2, and the level and/or activity of VASN in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of SEPP1, the level and/or activity of TAGLN2, and the level and/or activity of VASN, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the subject sample(s) with a level of CPN2, a level of TAGLN2, a level of IGFBP6, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CPN2, a difference in the level of TAGLN2, a difference in the level of IGFBP6, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) with a level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the first sample(s) as compared to the level of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CPN2, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CPN2, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CPN2, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CPN2, the level and/or activity of TAGLN2, the level and/or activity of IGFBP6, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of TAGLN2, a level of PFN1, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of TAGLN2, a difference in the level of PFN1, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of TAGLN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the TAGLN2, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of TAGLN2, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of TAGLN2, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of SEPP1, a level of PFN1, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of SEPP1, a difference in the level of PFN1, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of SEPP1, the level of PFN1, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the SEPP1, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of SEPP1, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of SEPP1, the level and/or activity of PFN1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of SEPP1, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of SEPP1, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of SEPP1, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of SEPP1, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of SEPP1, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of CD14, a level of CPN2, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of CD14, a difference in the level of CPN2, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the CD14, the level and/or activity of CPN2, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of CD14, the level and/or activity of CPN2, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of IGFBP6 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of IGFBP6 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in the second sample(s), wherein a difference in the level LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of the LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFBP6 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFBP6 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFBP6, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of LRG1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of LRG1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in an aliquot as compared to the level and/or activity of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level of VASN, the level of PFN1, and the level of LRG1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of APOA4 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of APOA4 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA4 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA4 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA4 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA4, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of BCHE in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of BCHE in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of BCHE in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of BCHE in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of BCHE of the invention in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of BCHE, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of PI16 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of PI16 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PI16 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PI16 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PI16 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of PI16, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of SEPP1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of APOA1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of APOA1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA1 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of APOA1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of IGFALS in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of IGFALS in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFALS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFALS in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFALS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of IGFALS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of CD14 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of CD14 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of CD14 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of CD14 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of CD14 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of CD14, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PFN1, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PFN1, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in the first sample(s) with a level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in the first sample(s) as compared to the level of the one or more markers in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PFN1, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1 and the level of TAGLN2 in a sample(s) from the subject; comparing the level of LCP1 and the level of TAGLN2 in the subject sample(s) with a level of LCP1 and a level of TAGLN2 in a control sample(s), wherein a difference in the level of LCP1 and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of LCP1 and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1 and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1 and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1 and the level of TAGLN2 in the first sample(s) with a level of LCP1 and the level of TAGLN2 in the second sample(s), wherein a difference in the level of LCP1 and the level of TAGLN2 in the first sample(s) as compared to the level of LCP1 and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1 and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1 and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of LCP1 and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1 and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, and the level of TAGLN2 in the subject sample(s) with a level of LCP1, a level of VASN, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of LCP1, the level of VASN, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, and the level of TAGLN2 in the first sample(s) with a level of LCP1, the level of VASN, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, and the level of TAGLN2 in the first sample(s) as compared to the level of LCP1, the level of VASN, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in the subject sample(s) with a level of LCP1, a level of VASN, a level of TAGLN2, and a level of IGFBP6 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of TAGLN2, and a difference in the level of IGFBP6 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in the first sample(s) with a level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in the second sample(s), wherein a difference in the level LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of TAGLN2, and the level and/or activity of IGFBP6 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of TAGLN2, and the level and/or activity of IGFBP6 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of TAGLN2, and the level and/or activity of IGFBP6, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of LRG1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of TAGLN2, and the level of LRG1 in the subject sample(s) with a level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of TAGLN2, and a difference in the level of LRG1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of TAGLN2, and the level of LRG1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in the first sample(s) with a level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in the second sample(s), wherein a difference in the level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in the first sample(s) as compared to the level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, a level and/or activity of VASN, a level and/or activity of TAGLN2, and a level and/or activity of LRG1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, a level and/or activity of VASN, a level and/or activity of TAGLN2, and a level and/or activity of LRG1 in an aliquot as compared to the level and/or activity of LCP1, a level and/or activity of VASN, a level and/or activity of TAGLN2, and a level and/or activity of LRG1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, a level and/or activity of VASN, a level and/or activity of TAGLN2, and a level and/or activity of LRG1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in the subject sample(s) with a level of LCP1, a level of VASN, a level of TAGLN2, and a level of SEPP1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of TAGLN2, and a difference in the level of SEPP1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in the first sample(s) with a level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level level and/or activity of VASN, the level level and/or activity of TAGLN2, and the level level and/or activity of SEPP1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level level and/or activity of VASN, the level level and/or activity of TAGLN2, and the level level and/or activity of SEPP1 in an aliquot as compared to the level and/or activity of LCP1, the level level and/or activity of VASN, the level level and/or activity of TAGLN2, and the level level and/or activity of SEPP1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level level and/or activity of VASN, the level level and/or activity of TAGLN2, and the level level and/or activity of SEPP1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1 and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of LCP1 and the level of PGLYRP2 in the subject sample(s) with a level of LCP1 and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of LCP1 and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of LCP1 and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1 and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1 and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1 and the level of PGLYRP2 in the first sample(s) with a level of LCP1 and the level of PGLYRP2 in the second sample(s), wherein a difference in the level of LCP1 and the level of PGLYRP2 in the first sample(s) as compared to the level of LCP1 and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1 and the level and/or activity of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1 and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of LCP1 and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1 and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, and the level of PGLYRP2 in the subject sample(s) with a level of LCP1, a level of VASN, and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of LCP1, the level of VASN, and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, and the level of PGLYRP2 in the first sample(s) with a level of LCP1, the level of VASN, and the level of PGLYRP2 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, and the level of PGLYRP2 in the first sample(s) as compared to the level of LCP1, the level of VASN, and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, and the level and/or activity of PGLYRP2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PGLYRP2, and a level of PFN1 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PGLYRP2, and a difference in the level of PFN1 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in the first sample(s) with a level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of PFN1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a sample(s) from the subject; comparing the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the subject sample(s) with a level of LCP1, a level of VASN, a level of PGLYRP2, and a level of TAGLN2 in a control sample(s), wherein a difference in the level of LCP1, a difference in the level of VASN, a difference in the level of PGLYRP2, and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the first sample(s) with a level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the second sample(s), wherein a difference in the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the first sample(s) as compared to the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of LCP1, the level and/or activity of VASN, the level and/or activity of PGLYRP2, and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1 and the level of PI16 in a sample(s) from the subject; comparing the level of PFN1 and the level of PI16 in the subject sample(s) with a level of PFN1 and a level of PI16 in a control sample(s), wherein a difference in the level of PFN1 and a difference in the level of PI16 in the subject sample(s) as compared to the level of PFN1 and the level of PI16 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1 and the level of PI16 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1 and the level of PI16 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1 and the level of PI16 in the first sample(s) with a level of PFN1 and the level of PI16 in the second sample(s), wherein a difference in the level of PFN1 and the level of PI16 in the first sample(s) as compared to the level of PFN1 and the level of PI16 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1 and the level and/or activity of PI16 of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1 and the level and/or activity of PI16 in an aliquot as compared to the level and/or activity of PFN1 and the level and/or activity of PI16 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1 and the level and/or activity of PI16, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1 and the level of PON1 in a sample(s) from the subject; comparing the level of PFN1 and the level of PON1 in the subject sample(s) with a level of PFN1 and a level of PON1 in a control sample(s), wherein a difference in the level of PFN1 and a difference in the level of PON1 in the subject sample(s) as compared to the level of PFN1 and the level of PON1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1 and the level of PON1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1 and the level of PON1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1 and the level of PON1 in the first sample(s) with a level of PFN1 and the level of PON1 in the second sample(s), wherein a difference in the level of PFN1 and the level of PON1 in the first sample(s) as compared to the level of PFN1 and the level of PON1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1 and the level and/or activity of PON1 of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1 and the level and/or activity of PON1 in an aliquot as compared to the level and/or activity of PFN1 and the level and/or activity of PON1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1 and the level and/or activity of PON1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1 and the level of PTGDS in a sample(s) from the subject; comparing the level of PFN1 and the level of PTGDS in the subject sample(s) with a level of PFN1 and a level of PTGDS in a control sample(s), wherein a difference in the level of PFN1 and a difference in the level of PTGDS in the subject sample(s) as compared to the level of PFN1 and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1 and the level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1 and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1 and the level of PTGDS in the first sample(s) with a level of PFN1 and the level of PTGDS in the second sample(s), wherein a difference in the level of PFN1 and the level of PTGDS in the first sample(s) as compared to the level of PFN1 and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1 and the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1 and the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity of PFN1 and the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1 and the level and/or activity of PTGDS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PI16 and the level of PON1 in a sample(s) from the subject; comparing the level of PI16 and the level of PON1 in the subject sample(s) with a level of PI16 and a level of PON1 in a control sample(s), wherein a difference in the level of PI16 and a difference in the level of PON1 in the subject sample(s) as compared to the level of PI16 and the level of PON1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PI16 and the level of PON1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PI16 and the level of PON1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PI16 and the level of PON1 in the first sample(s) with a level of PI16 and the level of PON1 in the second sample(s), wherein a difference in the level of PI16 and the level of PON1 in the first sample(s) as compared to the level of PI16 and the level of PON1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PI16 and the level and/or activity of PON1 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PI16 and the level and/or activity of PON1 in an aliquot as compared to the level and/or activity of PI16 and the level and/or activity of PON1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PI16 and the level and/or activity of PON1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PI16 and the level of PTGDS in a sample(s) from the subject; comparing the level of PI16 and the level of PTGDS in the subject sample(s) with a level of PI16 and a level of PTGDS in a control sample(s), wherein a difference in the level of PI16 and a difference in the level of PTGDS in the subject sample(s) as compared to the level of PI16 and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PI16 and the level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PI16 and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PI16 and the level of PTGDS in the first sample(s) with a level of PI16 and the level of PTGDS in the second sample(s), wherein a difference in the level of PI16 and the level of PTGDS in the first sample(s) as compared to the level of PI16 and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PI16 and the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PI16 and the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity of PI16 and the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PI16 and the level and/or activity of PTGDS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PON1 and the level of PTGDS in a sample(s) from the subject; comparing the level of PON1 and the level of PTGDS in the subject sample(s) with a level of PON1 and a level of PTGDS in a control sample(s), wherein a difference in the level of PON1 and a difference in the level of PTGDS in the subject sample(s) as compared to the level of PON1 and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PON1 and the level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PON1 and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PON1 and the level of PTGDS in the first sample(s) with a level of PON1 and the level of PTGDS in the second sample(s), wherein a difference in the level of PON1 and the level of PTGDS in the first sample(s) as compared to the level of PON1 and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PON1 and the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PON1 and the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity PON1 and the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PON1 and the level and/or activity of PTGDS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1, the level of PI16, and the level of PON1 in a sample(s) from the subject; comparing the level of PFN1, the level of PI16, and the level of PON1 in the subject sample(s) with a level of PFN1, a level of PI16, and a level of PON1 in a control sample(s), wherein a difference in the level of PFN1, a difference in the level of PI16, and a difference in the level of PON1 in the subject sample(s) as compared to the level of PFN1, the level of PI16, and the level of PON1 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1, the level of PI16, and the level of PON1 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1, the level of PI16, and the level of PON1 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1, the level of PI16, and the level of PON1 in the first sample(s) with a level of PFN1, the level of PI16, and the level of PON1 in the second sample(s), wherein a difference in the level of PFN1, the level of PI16, and the level of PON1 in the first sample(s) as compared to the level of PFN1, the level of PI16, and the level of PON1 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PON1 of the invention in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PON1 in an aliquot as compared to the level and/or activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PON1 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB. In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PON1, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1, the level of PI16, and the level of PTGDS in a sample(s) from the subject; comparing the level of PFN1, the level of PI16, and the level of PTGDS in the subject sample(s) with a level of PFN1, a level of PI16, and a level of PTGDS in a control sample(s), wherein a difference in the level of PFN1, a difference in the level of PI16, and a difference in the level of PTGDS in the subject sample(s) as compared to the level of PFN1, the level of PI16, and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1, the level of PI16, and the level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1, the level of PI16, and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1, the level of PI16, and the level of PTGDS in the first sample(s) with a level of PFN1, the level of PI16, and the level of PTGDS in the second sample(s), wherein a difference in the level of PFN1, the level of PI16, and the level of PTGDS in the first sample(s) as compared to the level of PFN1, the level of PI16, and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1, the level and/or activity of PI16, and the level and/or activity of PTGDS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PON1, the level of PI16, and the level of PTGDS in a sample(s) from the subject; comparing the level of PON1, the level of PI16, and the level of PTGDS in the subject sample(s) with a level of PON1, a level of PI16, and a level of PTGDS in a control sample(s), wherein a difference in the level of PON1, a difference in the level of PI16, and a difference in the level of PTGDS in the subject sample(s) as compared to the level of PON1, the level of PI16, and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PON1, the level of PI16, and the level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PON1, the level of PI16, and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PON1, the level of PI16, and the level of PTGDS in the first sample(s) with a level of PON1, the level of PI16, and the level of PTGDS in the second sample(s), wherein a difference in the level of PON1, the level of PI16, and the level of PTGDS in the first sample(s) as compared to the level of PON1, the level of PI16, and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PON1, the level and/or activity of PI16, and the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PON1, the level and/or activity of PI16, and the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity of PON1, the level and/or activity of PI16, and the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PON1, the level and/or activity of PI16, and the level and/or activity of PTGDS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1, the level of PI16, the level of PON1, and the level of PTGDS in a sample(s) from the subject; comparing the level of PFN1, the level of PI16, the level of PON1, and the level of PTGDS in the subject sample(s) with a level of PFN1, a level of PI16, a level of PON1, and a level of PTGDS in a control sample(s), wherein a difference in the level of PFN1, a difference in the level of PI16, a difference in the level of PON1, and a difference in the level of PTGDS in the subject sample(s) as compared to the level of PFN1, the level of PI16, the level of PON1, and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1, the level of PI16, the level of PON1 and a level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1, the level of PI16, the level of PON1 and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1, the level of PI16, the level of PON1 and the level of PTGDS in the first sample(s) with a level of PFN1, the level of PI16, the level of PON1 and the level of PTGDS in the second sample(s), wherein a difference in the level of PFN1, the level of PI16, the level of PON1 and the level of PTGDS in the first sample(s) as compared to the level of PFN1, the level of PI16, the level of PON1 and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1, the level and/or activity of PI16, the level and/or activity of PON1, and the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1, the level and/or activity of PI16, the level and/or activity of PON1 and the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity of PFN1, the level and/or activity of PI16, the level and/or activity of PON1 and the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1, the level and/or activity of PI16, the level and/or activity of PON1, and the level and/or activity of PTGDS thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of PFN1, the level of PON1, and the level of PTGDS in a sample(s) from the subject; comparing the level of PFN1, the level of PON1, and the level of PTGDS in the subject sample(s) with a level of PFN1, the level of PON1, and the level of PTGDS in a control sample(s), wherein a difference in the level of PFN1, a difference in the level of PON1, and a difference in the level of PTGDS, in the subject sample(s) as compared to the level of PFN1, the level of PON1, and the level of PTGDS in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of PFN1, the level of PON1, and the level of PTGDS in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of PFN1, the level of PON1, and the level of PTGDS in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of PFN1, the level of PON1, and the level of PTGDS in the first sample(s) with a level of PFN1, the level of PON1, and the level of PTGDS in the second sample(s), wherein a difference in the level of PFN1, the level of PON1, and the level of PTGDS in the first sample(s) as compared to the level of PFN1, the level of PON1, and the level of PTGDS in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of PFN1, the level and/or activity of PON1, the level and/or activity of PTGDS in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of PFN1, the level and/or activity of PON1, the level and/or activity of PTGDS in an aliquot as compared to the level and/or activity of PFN1, the level and/or activity of PON1, the level and/or activity of PTGDS in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of PFN1, the level and/or activity of PON1, the level and/or activity of PTGDS, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of VASN and the level of TAGLN2 in a sample(s) from the subject; comparing the level of VASN and the level of TAGLN2 in the subject sample(s) with a level of VASN and a level of TAGLN2 in a control sample(s), wherein a difference in the level of VASN and a difference in the level of TAGLN2 in the subject sample(s) as compared to the level of VASN and the level of TAGLN2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of VASN and the level of TAGLN2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of VASN and the level of TAGLN2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of VASN and the level of TAGLN2 in the first sample(s) with a level of VASN and the level of TAGLN2 in the second sample(s), wherein a difference in the level of VASN and the level of TAGLN2 in the first sample(s) as compared to the level of VASN and the level of TAGLN2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of VASN and the level and/or activity of TAGLN2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of VASN and the level and/or activity of TAGLN2 in an aliquot as compared to the level and/or activity of VASN and the level and/or activity of TAGLN2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of VASN and the level and/or activity of TAGLN2, thereby treating the subject.

In one aspect the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of VASN and the level of PGLYRP2 in a sample(s) from the subject; comparing the level of VASN and the level of PGLYRP2 in the subject sample(s) with a level of VASN and a level of PGLYRP2 in a control sample(s), wherein a difference in the level of VASN and a difference in the level of PGLYRP2 in the subject sample(s) as compared to the level of VASN and the level of PGLYRP2 in the control sample(s) indicates that the subject has active TB.

In one aspect the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of VASN and the level of PGLYRP2 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of VASN and the level of PGLYRP2 in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of VASN and the level of PGLYRP2 in the first sample(s) with a level of VASN and the level of PGLYRP2 in the second sample(s), wherein a difference in the level of VASN and the level of PGLYRP2 in the first sample(s) as compared to the level of VASN and the level of PGLYRP2 in the second sample(s) indicates that the treatment is effective.

In one aspect the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of VASN and the level and/or activity of PGLYRP2 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of VASN and the level and/or activity of PGLYRP2 in an aliquot as compared to the level and/or activity of VASN and the level and/or activity of PGLYRP2 in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of VASN and the level and/or activity of PGLYRP2, thereby treating the subject.

In one embodiment, the subject is HIV positive (HIV+).

In one embodiment, the methods further comprise determining the level of one or more additional markers selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, PGLYRP2, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS.

In another embodiment, the methods further comprise determining the level of one or more additional markers listed in Table 1.

In one embodiment, the level of the marker is an expression level and/or activity of the marker.

In one embodiment, the level in the subject sample(s) is determined by mass spectrometry. In one embodiment, the mass spectrometry is matrix assisted laser desorption/time of flight (MALDI/TOF) mass spectrometry, liquid chromatography quadruple ion trap electrospray (LCQ-MS), or surface enhanced laser desorption ionization/time of flight (SELDI/TOF) mass spectrometry. In another embodiment, the level in the subject sample(s) is determined by immunoassay.

In one embodiment, the sample(s) from the subject is a fluid sample(s). In another embodiment, the sample(s) from the subject is a tissue sample(s).

In one embodiment, the subject resides in North America or Europe.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of one or more markers listed in Table 1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of one or more markers listed in Table 1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14 and the level of APOE in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14 and the level of APOE in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD, the level of TNXB, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD, the level of TNXB, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD, the level of COMP, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD, the level of COMP, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD, the level of QSOX1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD, the level of QSOX1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD, the level of CD14, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD, the level of CD14, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PEPD, the level of LUM, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PEPD, the level of LUM, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of TNXB, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of TNXB, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of QSOX1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of QSOX1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of TNXB, the level of QSOX1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of TNXB, the level of QSOX1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of SEPP1, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, and the level of PEPD in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, and the level of PEPD in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of COMP, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of COMP, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of SELL, and the level of PEPD in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of SELL, and the level of PEPD in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of PEPD, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of APOC1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of APOC1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of APOC1, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of APOC1, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of GP1BA, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of GP1BA, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of QSOX1, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of QSOX1, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of SEPP1, the level of PEPD, the level of SELL, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of SEPP1, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of SEPP1, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of SEPP1, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of SEPP1, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of COMP, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of COMP, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of APOC1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of SELL, and the level of APOC1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of QSOX1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of QSOX1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. COMP, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of QSOX1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of QSOX1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of SEPP1, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of SEPP1, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of CD14, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of CD14, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of TNXB, the level of APOC1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of TNXB, the level of APOC1, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of GP1BA, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of GP1BA, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of APOC1, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of PEPD, the level of APOC1, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of CD14, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of CD14, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. APOC1, the level of CD14, the level of GP1BA, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of COMP, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of COMP, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of GP1BA, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of GP1BA, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of QSOX1, the level of LUM, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of QSOX1, the level of LUM, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of CD14, the level of LUM, and the level of APOC1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of CD14, the level of LUM, and the level of APOC1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of TNXB, the level of GP1BA, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of SEPP1, the level of CD14, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of SEPP1, the level of CD14, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LUM, the level of SELL, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LUM, the level of SELL, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of CD14, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of CD14, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of TNXB, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of TNXB, the level of LUM, the level of SELL, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of SELL, the level of TNXB, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of SELL, the level of TNXB, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. APOC1, the level of CD14, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of SELL, the level of COMP, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of SELL, the level of COMP, and the level of GP1BA in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of LUM, and the level of PEPD in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of LUM, and the level of PEPD in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of COMP, the level of LUM, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of COMP, the level of LUM, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of SEPP1, the level of SELL, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of LUM, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of LUM, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of CD14, the level of LUM, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of CD14, the level of LUM, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. APOC1, the level of COMP, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of COMP, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of COMP, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of SEPP1, the level of CD14, the level of GP1BA, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of SEPP1, the level of CD14, the level of GP1BA, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of TNXB, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of TNXB, the level of GP1BA, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of QSOX1, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of COMP, and the level of PEPD in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of COMP, and the level of PEPD in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of GP1BA, the level of SELL, the level of TNXB, and the level of COMP in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of GP1BA, the level of SELL, the level of TNXB, and the level of COMP in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of LUM, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of LUM, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of APOC1, the level of CD14, the level of PEPD, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of APOC1, the level of CD14, the level of PEPD, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of APOE, the level of SELL, and the level of TNXB in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of COMP in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of LUM in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of HABP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of LRG1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of QSOX1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of SELL, and the level of S100A8 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, and the level of APOC3 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, and the level of APOC3 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of APOE, the level of APOC3, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level CD14, the level of APOE, the level of APOC3, and the level of SELL in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of APOC3, and the level of SELL in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level CD14, the level of APOE, the level of APOC3, and the level of HABP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of APOE, the level of APOC3, and the level of HABP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1 and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1 and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1 and the level of VASN in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1 and the level of VASN in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of VASN and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of VASN and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LCP1, the level of VASN, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of LCP1, the level of VASN, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of CD14, the level of CPN2, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, and the level of TAGLN2 a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of CD14, the level of CPN2, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PGLYRP2, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of CD14, the level of PGLYRP2, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, and the level of IGFBP6 a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of CD14, the level of CPN2, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of CD14, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of VASN, and the level of TAGLN2 a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of CD14, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PGLYRP2, the level of VASN, and the level of TAGLN2 a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of PGLYRP2, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PGLYRP2, the level of VASN, and the level of PFN1 a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of of PGLYRP2, the level of VASN, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of CPN2, the level of PFN1, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of PGLYRP2, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of PGLYRP2, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of PFN1, and the level of VASN in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of IGFBP6, the level of TAGLN2, and the level of VASN in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of IGFBP6, the level of TAGLN2, and the level of VASN in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PGLYRP2, the level of CPN2, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PGLYRP2, the level of CPN2, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of IGFBP6, the level of VASN, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of IGFBP6, the level of VASN, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of CPN2, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of IGFBP6, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of PGLYRP2, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PFN1, the level of PGLYRP2, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of VASN, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of VASN, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of PFN1, the level of IGFBP6, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of TAGLN2, and the level of VASN in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PFN1, the level of TAGLN2, and the level of VASN in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of IGFBP6, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PFN1, the level of PGLYRP2, the level of VASN, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PFN1, the level of PGLYRP2, the level of VASN, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CPN2, the level of PFN1, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of SEPP1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of TAGLN2, the level of SEPP1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CPN2, the level of PFN1, the level of IGFBP6, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of PFN1, the level of IGFBP6, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CPN2, the level of PFN1, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of PFN1, the level of VASN, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. CD14, the level of PFN1, the level of VASN, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of SEPP1, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of SEPP1, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CPN2, the level of IGFBP6, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CPN2, the level of IGFBP6, the level of TAGLN2, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PGLYRP2, the level of PFN1, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PGLYRP2, the level of PFN1, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of PGLYRP2, the level of PFN1, the level of VASN, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PGLYRP2, the level of PFN1, the level of VASN, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of SEPP1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of CD14, the level of CPN2, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of LRG1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. LCP1, the level of VASN, the level of PFN1, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA4 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of BCHE in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of BCHE in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of PI16 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of PI16 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of APOA1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of IGFALS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of CD14 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of CD14 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PFN1, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1 and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. LCP1 and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of IGFBP6 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, a level of VASN, a level of TAGLN2, and a level of LRG1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of TAGLN2, and the level of SEPP1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1 and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1 and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of PFN1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of LCP1, the level of VASN, the level of PGLYRP2, and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1 and the level of PI16 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB. PFN1 and the level of PI16 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1 and the level of PON1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PFN1 and the level of PON1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1 and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PFN1 and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PI16 and the level of PON1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PI16 and the level of PON1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PI16 and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PI16 and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PON1 and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of PON1 and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1, the level of PI16, and the level of PON1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level PFN1, the level of PI16, and the level of PON1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1, the level of PI16, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level PFN1, the level of PI16, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PON1, the level of PI16, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level PON1, the level of PI16, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1, the level of PON1, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits for determining whether a subject has treatment in a subject having active TB. The kits include reagents for determining the level PFN1, the level of PON1, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level PFN1, the level of PI16, the level of PON1, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level PFN1, the level of PI16, the level of PON1, and the level of PTGDS in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level VASN and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level VASN and the level of TAGLN2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The kits include reagents for determining the level VASN and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level VASN and the level of PGLYRP2 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one embodiment, the kits further comprise reagents for determining the level of any one or more of the markers listed in Table 1 in a sample(s) from the subject.

In one embodiment, the kits further comprise reagents for determining the level of one or more additional markers selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, PGLYRP2, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS in a sample(s) from the subject.

In one embodiment, the sample is from an HIV− subject. In another embodiment, the sample is from an HIV+ subject.

In one embodiment, the subject resides in North America or Europe.

In one aspect, the present invention provides methods for identifying an active tuberculosis (TB) marker. The methods include identifying proteins differentially expressed in a sample(s) from an HIV+ subject having active TB and identifying proteins differentially expressed in a sample(s) from an HIV− subject having active TB, thereby generating a provisional list of active TB markers; determining the level of one or more of the provisional markers in a control sample; and determining the level of the one or more provisional markers in a test sample, wherein a difference in the level of a marker in the control sample as compared to the level in the test sample identifies the marker as an active TB marker.

In one aspect, the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of each marker in any one of the combination of markers set forth in any one of Tables 3, 4, 6, 7, 8, 10, 11, and 12 in a sample(s) from the subject; comparing the level of each of the markers of the combination in the subject sample(s) with a level of each of the markers of the combination in a control sample(s), wherein a difference in the level of all of the markers of the combination in the subject sample(s) as compared to the level of all of the markers of the combination in the control sample(s) indicates that the subject has active TB.

In one aspect, the present invention provides methods for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB). The methods include determining the level of any one of the combination of markers set forth in any one of Tables 3, 4, 6, 7, 8, 10, 11, and 12 in a first sample(s) from the subject prior to the initiation of the treatment; determining the level of each of the markers of the combination in a second sample(s) from the subject after at least a portion of the treatment has been administered; comparing the level of each of the markers of the combination in the first sample(s) with a level of each of the markers of the combination in the second sample(s), wherein a difference in the level of all of the markers of the combination in the first sample(s) as compared to the level of all of the markers of the combination in the second sample(s) indicates that the treatment is effective.

In one aspect, the present invention provides methods for identifying a compound that is useful for treating a subject having active tuberculosis (TB). The methods include contacting an aliquot of a sample(s) from the subject with each member of a library of compounds; determining the effect of a member of the library of compounds on the level and/or activity of each marker in any one of the combination of markers set forth in any one of Tables 3, 4, 6, 7, 8, 10, 11, and 12 in each of the aliquots; and selecting a member of the library of compounds which modulates the level and/or the activity of each of the markers of the combination in an aliquot as compared to the level and/or activity of each of the markers of the combination in a control sample, thereby identifying a compound that is useful for treating a subject having active TB.

In one aspect, the present invention provides methods for treating a subject having active tuberculosis (TB). The methods include administering to the subject an effective amount of an agent that modulates the expression and/or activity of each marker in any one of the combination of markers set forth in any one of Tables 3, 4, 6, 7, 8, 10, 11, and 12, thereby treating the subject.

In one embodiment, the combination of markers has an area under the curve (AUC) of about 0.85 to about 1.00.

In one aspect, the present invention provides kits for determining whether a subject has active tuberculosis (TB). The list include reagents for determining the level of each marker in any one of the combination of markers set forth in any one of Tables 3, 4, 6, 7, 8, 10, 11, and 12 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

In one aspect, the present invention provides kits for monitoring the effectiveness of a treatment in a subject having active TB. The kits include reagents for determining the level of each marker in any one of the combination of markers set forth in any one of Tables 3, 4, 6, 7, 8, 10, 11, and 12 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

In one embodiment, the combination of markers has an area under the curve (AUC) of about 0.85 to about 1.00.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1A-1F depict the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls. The differentially expressed proteins are indicated by dots arranged in the functional groups indicated. Intensity values per protein were normalized and the ratios derived were displayed in logarithmic scale (y-axis). Medians and standard deviations of the expression ratio of TB versus latent TB and non-infected is shown. Proteins were sorted by increasing differential expression.

FIG. 1A depicts the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls associated with the functional group, coagulation.

FIG. 1B depicts the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls associated with the functional group, immune cell trafficking.

FIG. 1C depicts the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls associated with the functional group, inflammatory response.

FIG. 1D depicts the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls associated with the functional group, lipid transport and regulation.

FIG. 1E depicts the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls associated with the functional group, tissue development.

FIG. 1F depicts the differentially expressed proteins in serum of HIV− subjects with TB relative to latent TB and non-infected controls associated with other miscellaneous functional groups.

FIG. 2 depicts the differential expression of candidate biomarkers in serum of subjects with active TB relative to latent TB, non-infected controls, and subjects with other pulmonary infections. The comparisons were done in the context of HIV+ or HIV− co-infections. Shown are color-coded expression change ratios for each biomarker and comparison. Red represents up to an 8-fold increase in the numerator vs the denominator denoted per comparison, with the darker color representing the larger increases. Blue represents up to an 8-fold decrease in the numerator vs the denominator, with the darker color representing the larger decreases. White represents no change between numerator and denominator TB=active TB; NI=non-infected; LI=latent TB infection; ORD=other respiratory disease.

 DETAILED DESCRIPTION OF THE INVENTION

The present invention is based, at least in part, on the discovery of markers that are associated with active tuberculosis (TB). In particular, biomarkers associated with active TB have been discovered, prioritized, and validated in relevant in vitro experimental systems. The markers were identified as being expressed, e.g., essentially specifically expressed, in samples from subjects having active TB as compared to subjects having latent TB and/or other respiratory diseases (ORD) or pneumonias, such as community acquired pneumonia (viral or bacterial), non-tuberculous mycobacteria, pneumocysitis jiroveci pneumonia, methcillin resistant Staphylococcus aureus infection, viral pneumonia, and lung cancer.

Accordingly, the present invention provides sensitive and facile methods and kits for determining whether a subject has active TB, methods for identifying a compound that is useful for treating active TB, methods and kits for monitoring the effectiveness of a therapy for treating a subject having active TB, and methods for treating a subject having active TB by measuring and identifying particular markers, or particular combinations of markers.

Various aspects of the invention are described in further detail in the following subsections:

I. Definitions

As used herein, each of the following terms has the meaning associated with it in this section.

The articles “a” and “an” are used herein to refer to one or to more than one (i.e. to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.

A “marker” or “biomarker” is an organic biomolecule which is differentially present in a sample taken from a subject of one phenotypic status (e.g., having a disease) as compared with another phenotypic status (e.g., not having the disease). A biomarker is differentially present between different phenotypic statuses if the mean or median level, e.g., expression level, of the biomarker in the different groups is calculated to be statistically significant. Common tests for statistical significance include, among others, t-test, ANOVA, Kruskal-Wallis, Wilcoxon, Mann-Whitney and odds ratio. Biomarkers, alone or in combination, provide measures of relative risk that a subject belongs to one phenotypic status or another. As such, they are useful as markers for, e.g., disease (prognostics and diagnostics), therapeutic effectiveness of a drug (theranostics) and of drug toxicity.

In some embodiments, the accuracy of a marker(s) useful in the compositions and methods of the present invention may be characterized by a Receiver Operating Characteristic curve (“ROC curve”). An ROC is a plot of the true positive rate against the false positive rate for the different possible cutpoints of a diagnostic marker(s). An ROC curve shows the relationship between sensitivity and specificity. That is, an increase in sensitivity will be accompanied by a decrease in specificity. The closer the curve follows the left axis and then the top edge of the ROC space, the more accurate the marker(s). Conversely, the closer the curve comes to the 45-degree diagonal of the ROC graph, the less accurate the marker(s). The area under the ROC is a measure of a marker(s) accuracy. The accuracy of the marker(s) depends on how well the marker(s) separates the group being tested into those with and without the disease in question. An area under the curve (referred to as “AUC”) of 1 represents a perfect marker(s), while an area of 0.5 represents a less useful marker(s). Thus, in some embodiments, biomarker(s) and methods of the present invention have an AUC greater than about 0.50, an AUC greater than about 0.60, or an AUC greater than about 0.70.

“Tuberculosis” (“TB”) is a multisystemic disease with myriad presentations and manifestations, and is the most common cause of infectious disease-related mortality worldwide. Mycobacterium tuberculosis, a tubercle bacillus, is the causative agent of TB. The lungs are the most common site for the development of TB (pulmonary TB), and about 85% of patients with TB present with pulmonary complaints. Nonetheless, “extrapulmonary TB”, e.g., “disseminated TB”, can occur as part of a primary or late, generalized infection. Extrapulmonary TB can affect bones and joints, bronchus, eye, intestines, larynx, peritoneum, meninges, pericardium, lymph node, organs of the male or female urinary and reproductive systems, skin, stomach, and/or urinary systems.

When a person is infected with M. tuberculosis, the infection can take one of a variety of paths, most of which do not lead to actual TB. The infection may be cleared by the host immune system or suppressed into an inactive form called “latent tuberculosis infection”, with resistant hosts controlling mycobacterial growth at distant foci before the development of active disease.

A subject has “latent tuberculosis (“LTB”) (also referred to as “latent tuberculosis infection” (“LTBI”)) when the subject is infected with Mycobacterium tuberculosis but does not have active tuberculosis disease. Subjects having latent tuberculosis are not infectious. The main risk is that approximately 10% of these patients (5% in the first two years after infection and 0.1% per year thereafter but higher risk if immunosuppressed) will go on to develop “active tuberculosis” (“active TB”) and spread the disease at a later stage of their life if, for example, there is onset of a disease affecting the immune system (such as AIDS) or a disease whose treatment affects the immune system (e.g., chemotherapy in cancer or systemic steroids in asthma or Enbrel, Humira or Orencia in rheumatoid arthritis); malnutrition (which may be the result of illness or injury affecting the digestive system, or of a prolonged period of not eating, or disturbance in food availability such as famine, residence in refugee camp or concentration camp, or civil war; and/or degradation of the immune system due to aging.

“Miliary tuberculosis” (also known as “disseminated tuberculosis”, “tuberculosis cutis acuta generalisata”, and “Tuberculosis cutis disseminata”) is a form of tuberculosis that is characterized by a wide dissemination into the human body and by the tiny size of the lesions (1-5 mm). Miliary tuberculosis is characterized by a chronic and contagious Mycobacterium tuberculosis infection that has spread to other organs of the body by the blood or lymph system. Its name comes from a distinctive pattern seen on a chest X-ray of many tiny spots distributed throughout the lung fields with the appearance similar to millet seeds—thus the term “miliary” tuberculosis. Miliary TB may infect any number of organs, including, for example, the lungs, liver, and spleen. Disseminated disease can occur within weeks of the primary infection, or may lie inactive for years before causing illness. Infants, the elderly, those infected with HIV, and those who take immune-suppressing medications are at higher risk for disseminated TB, because of their weaker immune systems.

The symptoms of a subject having TB are similar to the symptoms of a subject having an “other respiratory disease” or “ORD”, such a pneumonia, and include, for example, cough (e.g., coughing that lasts three or more weeks, coughing up blood or sputum, chest pain, or pain with breathing or coughing), unintentional weight loss, fatigue, fever, night sweats, chills, and/or loss of appetite.

Methods to diagnose a subject as having active and/or latent TB are known in the art. The primary screening method for TB infection (active or latent) is the Mantoux tuberculin skin test with purified protein derivative (PPD). An in vitro blood test based on interferon-gamma release assay (IGRA) with antigens specific for M. tuberculosis can also be used to screen for latent TB infection. Chest X-rays and culturing of sputum samples may also be used.

A subject having latent TB usually has a skin test or blood test result indicating TB infection; has a normal chest x-ray and a negative sputum test; has TB bacteria in his/her body that are alive, but inactive; does not feel sick (e.g. does not have a cough and/or fever); and cannot spread TB bacteria to others. A subject having active TB usually has a positive skin test or tuberculosis blood test, may have an abnormal chest x-ray, or positive sputum smear or culture; has overt indications of illness (e.g., cough and/or fever), and can spread the disease to others.

Human immunodeficiency virus (HIV) is a lentivirus (slowly-replicating retrovirus) that causes acquired immunodeficiency syndrome (AIDS), an infectious disease in which progressive failure of the human immune system leads to life-threatening opportunistic infections and/or cancer.

HIV-1 testing is initially by an enzyme-linked immunosorbent assay (ELISA) to detect antibodies to HIV-1. Subjects are considered “HIV-negative” (“HIV−”) if samples from the subject have a nonreactive result from the initial ELISA unless new exposure to an infected partner or partner of unknown HIV status has occurred. Subject samples with a reactive ELISA result are retested in duplicate. If the result of either duplicate test is reactive, the subject specimen is reported as repeatedly reactive and undergoes confirmatory testing with a more specific supplemental test (e.g., Western blot or an immunofluorescence assay (IFA)). Only subject samples that are repeatedly reactive by ELISA and positive by IFA or reactive by Western blot are considered “HIV-positive” (“HIV+”) and indicative of HIV infection.

Specimens that are repeatedly ELISA-reactive occasionally provide an indeterminate Western blot result, which may be either an incomplete antibody response to HIV in an infected person or nonspecific reactions in an uninfected person.

Although IFA can be used to confirm infection in these ambiguous cases, this assay is not widely used. In general, a second specimen is collected more than a month later and retested for persons with indeterminate Western blot results. Although much less commonly available, nucleic acid testing (e.g., viral RNA or proviral DNA amplification method) can also help diagnosis in certain situations. In addition, a few tested specimens might provide inconclusive results because of a low quantity specimen. In these situations, a second specimen is collected and tested for HIV infection.

A “level of a marker” or “the level of a biomarker” refers to an amount of a marker present in a sample being tested. A level of a marker may be either in absolute level or amount (e.g., μg/ml) or a relative level or amount (e.g., relative intensity of signals).

A “higher level” or an “increase in the level” of marker refers to a level of a marker in a test sample that is greater than the standard error of the assay employed to assess the level of the marker, and is preferably at least twice, and more preferably three, four, five, six, seven, eight, nine, or ten or more times the level of marker in a control sample (e.g., a sample from a subject having latent TB, a subject having an ORD, an HIV− subject, an HIV+ subject, an HIV− subject having latent TB, and HIV+ subject having latent TB, an HIV− subject having an ORD, and HIV+ subject having an ORD, and/or, the average level of the marker in several control samples).

A “lower level” or a “decrease in the level” of a marker refers to a level of the marker in a test sample that is less than the standard error of the assay employed to assess the level of the marker, and preferably at least twice, and more preferably three, four, five, six, seven, eight, nine, or ten or more times less than the level of the marker in a control sample (e.g., a sample from a subject having latent TB, a subject having an ORD, an HIV− subject, an HIV+ subject, an HIV− subject having latent TB, and HIV+ subject having latent TB, an HIV− subject having an ORD, and HIV+ subject having an ORD, and/or, the average level of the marker in several control samples).

The term “known standard level” or “control level” refers to an accepted or pre-determined level of a marker which is used to compare the level of the marker in a sample derived from a subject. In one embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) having latent TB. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) having an ORD. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) that is HIV−. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) that is HIV+. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) that is HIV− subject and has latent TB. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) that is HIV+ and has latent TB. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) that is HIV− subject and has an ORD. In another embodiment, the control level of a marker is based the level of the marker in a sample(s) from a subject(s) that is HIV+ subject and has an ORD, and/or, the average level of the marker in several control samples. In one embodiment, the control level of a marker in a sample from a subject is a level of the marker previously determined in a sample(s) from the subject. In yet another embodiment, the control level of a marker is based on the level of the marker in a sample from a subject(s) prior to the administration of a therapy for TB. In another embodiment, the control level of a marker is based on the level of the marker in a sample(s) from a subject(s) having active TB that is not contacted with a test compound. In another embodiment, the control level of a marker is based on the level of the marker in a sample(s) from a subject(s) having latent TB that is not contacted with a test compound. In another embodiment, the control level of a marker is based on the level of the marker in a sample(s) from a subject(s) having active TB that is contacted with a test compound. In another embodiment, the control level of a marker is based on the level of the marker in a sample(s) from a subject(s) having latent TB that is contacted with a test compound. In one embodiment, the control level of a marker is based on the expression level of the marker in a sample(s) from an animal model of TB, a cell, or a cell line derived from the animal model of TB.

Alternatively, and particularly as further information becomes available as a result of routine performance of the methods described herein, population-average values for “control” level of expression of a marker may be used. In other embodiments, the “control” level of a marker may be determined by determining the level of a marker in a subject sample obtained from a subject before the onset of active TB, from archived subject samples, and the like.

As used herein, the terms “patient” or “subject” refer to human and non-human animals, e.g., veterinary patients. The term “non-human animal” includes all vertebrates, e.g., mammals and non-mammals, such as non-human primates, mice, rabbits, sheep, dog, cat, horse, cow, chickens, amphibians, and reptiles. In one embodiment, the subject is a human, e.g., a pediatric and adult human. In one embodiment, a subject is HIV negative (HIV−). In another embodiment, the subject is HIV positive (HIV+). In another embodiment, the HIV status of the subject is unknown. In one embodiment, the subject resides in North America. In another embodiment, the subject resides in Europe. In another embodiment, the subject resides in Europe and is of European descent. In yet another embodiment, the subject resides in Europe and is not of European descent.

The term “sample” as used herein refers to a collection of similar cells or tissue isolated from a subject, as well as tissues, cells and fluids present within a subject. The term “sample” includes any body fluid (e.g., blood fluids, lymph, gynecological fluids, cystic fluid, urine, ocular fluids and fluids collected by bronchial lavage and/or peritoneal rinsing), or a cell from a subject. In one embodiment, the tissue or cell is removed from the subject. In another embodiment, the tissue or cell is present within the subject. Other subject samples include tear drops, serum, cerebrospinal fluid, feces, sputum and cell extracts. In one embodiment the sample is a blood sample. In another embodiment, the sample is a serum sample. In one embodiment, the biological sample contains protein molecules from the test subject. In another embodiment, the biological sample may contain mRNA molecules from the test subject or genomic DNA molecules from the test subject.

The term “determining” means methods which include detecting the presence or absence of marker(s) in the sample, quantifying the amount of marker(s) in the sample, and/or qualifying the type of biomarker. Measuring can be accomplished by methods known in the art and those further described herein.

As used herein, the various forms of the term “modulate” are intended to include stimulation (e.g., increasing or upregulating a particular response or activity) and inhibition (e.g., decreasing or downregulating a particular response or activity).

A kit is any manufacture (e.g. a package or container) comprising at least one reagent, e.g. a probe, a primer, or an antibody, for specifically detecting a marker of the invention, the manufacture being promoted, distributed, or sold as a unit for performing the methods of the present invention. In certain embodiments, a kit may include a substrate, e.g., a substrate comprising a capture reagent for one or more markers of the invention and/or a capture reagent bound to one or more markers of the invention. In some embodiments, such kits comprise instructions for determining the level of a marker(s) using mass spectrometry.

II. Markers of the Invention

The present invention is based upon the discovery of markers that are essentially specifically expressed in samples from subjects having active pulmonary tuberculosis (TB) (Table 1). These markers have been shown to be differentially present in samples of subjects (e.g., HIV− and HIV+ subjects) having active TB (i.e., active pulmonary TB) and control subjects.

Accordingly, the level of any one marker or any combination of markers listed in Tables 1 and found in a test sample compared to a control, or the presence or absence of one marker or combination of markers listed in Table 1 in the test sample may be used in the methods and kits of the present invention.

The markers of the invention are listed in Table 1 and are suitable for use in test samples from subjects in which the HIV status is unknown or in subjects in which the HIV status is known (i.e., subjects that are HIV+ or HIV−). The nucleotide and amino acid sequences of the markers are known in the art and may be found in, for example, the GenBank Accession numbers listed in Table 1, the entire contents of which are incorporated herein by reference.

TABLE 1 Markers of the Invention. UNIPROT GENBANK Marker Name Protein Description UNIPROT_ID ACCESSION ACCESSION YWHAE 14-3-3 protein epsilon 1433E_HUMAN P62258 NP_006752.1 NM_006761.4 YWHAZ 14-3-3 protein 1433Z_HUMAN P63104 NP_001129171.1 zeta/delta NP_001129172.1 NP_001129173.1 NP_001129174.1 NP_003397.1 NP_663723.1 NM_001135699.1 NM_001135700.1 NM_001135701.1 NM_001135702.1 NM_003406.3 NM_145690.2 ORM1 Alpha-1-acid A1AG1_HUMAN P02763 NP_000598.2 glycoprotein 1 NM_000607.2 precursor LRG1 Leucine-rich alpha-2- A2GL_HUMAN P02750 NP_443204.1 glycoprotein precursor NM_052972.2 IGFALS Insulin-like growth ALS_HUMAN P35858 NP_001139478.1 factor-binding protein NP_004961.1 complex acid labile NM_001146006.1 subunit precursor NM_004970.2 ANPEP Aminopeptidase N AMPN_HUMAN P15144 NP_001141.2 NM_001150.2 LPA Apolipoprotein(a) APOA_HUMAN P08519 NP_005568.2 precursor NM_005577.2 APOA1 Apolipoprotein A-I APOA1_HUMAN P02647 NP_000030.1 precursor NM_000039.1 APOA4 Apolipoprotein A-IV APOA4_HUMAN P06727 NP_000473.2 precursor NM_000482.3 APOC1 Apolipoprotein C-I APOC1_HUMAN P02654 NP_001636.1 precursor NM_001645.3 APOC3 Apolipoprotein C-III APOC3_HUMAN P02656 NP_000031.1 precursor NM_000040.1 APOE Apolipoprotein E APOE_HUMAN P02649 NP_000032.1 precursor NM_000041.2 ATRN Attractin precursor ATRN_HUMAN O75882 NP_001193976.1 NP_647537.1 NP_647538.1 NM_001207047.1 NM_139321.2 NM_139322.2 TGFBI Transforming growth BGH3_HUMAN Q15582 NP_000349.1 factor-beta-induced NM_000358.2 protein ig-h3 precursor BTD Biotinidase precursor BTD_HUMAN P43251 NP_000051.1 NM_000060.2 CD163 Scavenger receptor C163A_HUMAN Q86VB7 NP_004235.4 cysteine-rich type 1 NP_981961.2 protein M130 NM_004244.5 precursor NM_203416.3 CACNA2D1 Voltage-dependent CA2D1_HUMAN P54289 NP_000713.2 calcium channel NM_000722.2 subunit alpha-2/delta-1 precursor CDH5 Cadherin-5 precursor CADH5_HUMAN P33151 NP_001786.2 NM_001795.3 CA1 Carbonic anhydrase 1 CAH1_HUMAN P00915 NP_001122301.1 NP_001122302.1 NP_001122303.1 NP_001158302.1 NP_001729.1 NM_001128829.2 NM_001128830.2 NM_001128831.2 NM_001164830.1 NM_001738.3 CA2 Carbonic anhydrase 2 CAH2_HUMAN P00918 NP_000058.1 NM_000067.2 CPB2 Carboxypeptidase B2 CBPB2_HUMAN Q96IY4 NP_001863.2 precursor NM_001872.3 CPN1 Carboxypeptidase N CBPN_HUMAN P15169 NP_001299.1 catalytic chain NM_001308.2 precursor CD14 Monocyte CD14_HUMAN P08571 NP_000582.1 differentiation antigen NP_001035110.1 CD 14 precursor NP_001167575.1 NP_001167576.1 NM_000591.3 NM_001040021.2 NM_001174104.1 NM_001174105.1 BCHE Cholinesterase CHLE_HUMAN P06276 NP_000046.1 precursor NM_000055.2 CLU Clusterin precursor CLUS_HUMAN P10909 NP_001822.3 NM_001831.3 CNDP1 Beta-Ala-His CNDP1_HUMAN Q96KN2 NP_116038.4 dipeptidase precursor NM_032649.5 CNTN1 Contactin-1 precursor CNTN1_HUMAN Q12860 NP_001242992.1 NP_001242993.1 NP_001834.2 NP_778203.1 NM_001256063.1 NM_001256064.1 NM_001843.3 NM_175038.2 COMP Cartilage oligomeric COMP_HUMAN P49747 NP_000086.2 matrix protein NM_000095.2 precursor CPN2 Carboxypeptidase N CPN2_HUMAN P22792 NP_001073982.2 subunit 2 precursor NM_001080513.2 DBH Dopamine beta- DOPO_HUMAN P09172 NP_000778.3 hydroxylase NM_000787.3 ECM1 Extracellular matrix ECM1_HUMAN Q16610 NP_001189787.1 protein 1 precursor NP_004416.2 NP_073155.2 NM_001202858.1 NM_004425.3 NM_022664.2 PROCR Endothelial protein C EPCR_HUMAN Q9UNN8 NP_006395.2 receptor precursor NM_006404.3 FCN3 Ficolin-3 precursor FCN3_HUMAN O75636 NP_003656.2 NP_775628.1 NM_003665.2 NM_173452.1 GP1BA Platelet glycoprotein GP1BA_HUMAN P07359 NP_000164.5 Ib alpha chain NM_000173.5 precursor GP5 Platelet glycoprotein GPV_HUMAN P40197 NP_004479.1 V precursor NM_004488.2 GPX3 Glutathione GPX3_HUMAN P22352 NP_002075.2 peroxidase 3 NM_002084.3 precursor HIST2H2BE Histone H2B type 2-E H2B2E_HUMAN Q16778 NP_003519.1 NM_003528.2 HABP2 Hyaluronan-binding HABP2_HUMAN Q14520 NP_001171131.1 protein 2 precursor NP_004123.1 NM_001177660.1 NM_004132.3 HGFAC Hepatocyte growth HGFA_HUMAN Q04756 NP_001519.1 factor activator NM_001528.2 precursor MST1 Hepatocyte growth HGFL_HUMAN P26927 NP_066278.3 factor-like protein NM_020998.3 precursor HYOU1 Hypoxia up-regulated HYOU1_HUMAN Q9Y4L1 NP_001124463.1 protein 1 precursor NP_006380.1 NM_001130991.1 NM_006389.3 IGFBP3 Insulin-like growth IBP3_HUMAN P17936 NP_000589.2 factor-binding protein NP_001013416.1 3 precursor NM_000598.4 NM_001013398.1 IGFBP6 Insulin-like growth IBP6_HUMAN P24592 NP_002169.1 factor-binding protein NM_002178.2 6 precursor IGF2 Insulin-like growth IGF2_HUMAN P01344 NP_000603.1 factor II precursor NP_001007140.2 NM_000612.4 NM_001007139.4 CKM Creatine kinase M- KCRM_HUMAN P06732 NP_001815.2 type NM_001824.4 KNG1 Kininogen-1 precursor KNG1_HUMAN P01042 NP_000884.1 NP_001095886.1 NM_000893.3 NM_001102416.2 LCAT Phosphatidylcholine- LCAT_HUMAN P04180 NP_000220.1 sterol acyltransferase NM_000229.1 precursor LGALS3BP Galectin-3-binding LG3BP_HUMAN Q08380 NP_005558.1 protein precursor NM_005567.3 LUM Lumican precursor LUM_HUMAN P51884 NP_002336.1 NM_002345.3 SELL L-selectin precursor LYAM1_HUMAN P14151 NP_000646.2 NM_000655.4 MAN1A1 Mannosyl- MA1A1_HUMAN P33908 NP_005898.2 oligosaccharide 1,2- NM_005907.3 alpha-mannosidase IA MASP1 Mannan-binding MASP1_HUMAN P48740 NP_001027019.1 lectin serine protease NP_001870.3 1 precursor NP_624302.1 NM_001031849.2 NM_001879.5 NM_139125.3 MASP2 Mannan-binding MASP2_HUMAN O00187 NP_006601.2 lectin serine protease NP_631947.1 2 precursor NM_006610.3 NM_139208.2 Mtb81 Malate synthase G MASZ_MYCTU P0A5J4 NP_216353.1 NP_336342.1 NC_000962.2 NC_002755.2 NC_018143.1 MINPP1 Multiple inositol MINP1_HUMAN Q9UNW1 NP_001171588.1 polyphosphate NP_001171589.1 phosphatase 1 NP_004888.2 precursor NM_001178117.1 NM_001178118.1 NM_004897.4 MTP51 MPT51/MPB51 antigen MPT51_MYCTU P0A4V6 NP_338462.1 NC_002755.2 NC_018143.1 NC_000962.2 NCAM1 Neural cell adhesion NCAM1_HUMAN P13591 NP_000606.3 molecule 1 precursor NP_001070150.1 NP_001229537.1 NP_851996.2 NM_000615.6 NM_001076682.3 NM_001242608.1 NM_81351.4 NID1 Nidogen-1 precursor NID1_HUMAN P14543 NP_002499.2 NM_002508.2 PCSK9 Proprotein convertase PCSK9_HUMAN Q8NBP7 NP_777596.2 subtilisin/kexin type 9 NM_174936.3 precursor PDLIM1 PDZ and LIM domain PDLI1_HUMAN O00151 NP_066272.1 protein 1 NM_020992.3 PEPD Xaa-Pro dipeptidase PEPD_HUMAN P12955 NP_000276.2 NP_001159528.1 NP_001159529.1 NM_000285.3 NM_001166056.1 NM_001166057.1 PGLYRP2 N-acetylmuramoyl-L- PGRP2_HUMAN Q96PD5 NP_443122.3 alanine amidase NM_052890.3 precursor GPLD1 Phosphatidylinositol- PHLD_HUMAN P80108 NP_001494.2 glycan-specific NM_001503.3 phospholipase D precursor PI16 Peptidase inhibitor 16 PI16_HUMAN Q6UXB8 NP_001186088.1 precursor NP_699201.2 NM_001199159.1 NM_153370.2 LCP1 Plastin-2 PLSL_HUMAN P13796 NP_002289.2 NM_002298.4 PON1 Serum PON1_HUMAN P27169 NP_000437.3 paraoxonase/arylesterase 1 NM_000446.5 PRDX2 Peroxiredoxin-2 PRDX2_HUMAN P32119 NP_005800.3 NP_859428.1 NM_005809.4 NM_181738.1 PRG4 Proteoglycan 4 PRG4_HUMAN Q92954 NP_001121180.1 precursor NP_001121181.1 NP_001121182.1 NP_005798.2 NM_001127708.1 NM_001127709.1 NM_001127710.1 NM_005807.3 PFN1 Profilin-1 PROF1_HUMAN P07737 NP_005013.1 NM_005022.3 PROS1 Vitamin K-dependent PROS_HUMAN P07225 NP_000304.2 protein S precursor NM_000313.3 PTGDS Prostaglandin-H2 D- PTGDS_HUMAN P41222 NP_000945.3 isomerase precursor NM_000954.5 PTPRG Receptor-type PTPRG_HUMAN P23470 NP_002832.3 tyrosine-protein NM_002841.3 phosphatase gamma precursor QSOX1 Sulfhydryl oxidase 1 QSOX1_HUMAN O00391 NP_001004128.1 precursor NP_002817.2 NM_001004128.2 NM_002826.4 S100A8 Protein S100-A8 S10A8_HUMAN P05109 NP_002955.2 NM_002964.4 S100A9 Protein S100-A9 S10A9_HUMAN P06702 NP_002956.1 NM_002965.3 SEPP1 Selenoprotein P SEPP1_HUMAN P49908 NP_001078955.1 precursor NP_005401.3 NM_001085486.1 NM_005410.2 SHBG Sex hormone-binding SHBG_HUMAN P04278 NP_001031.2 globulin precursor NP_001139752.1 NP_001139753.1 NM_001040.3 NM_001146280.1 NM_001146281.1 SPP2 Secreted SPP24_HUMAN Q13103 NP_008875.1 phosphoprotein 24 NM_006944.2 precursor SPARC SPARC precursor SPRC_HUMAN P09486 NP_003109.1 NM_003118.3 TAGLN2 Transgelin-2 TAGL2_HUMAN P37802 NP_003555.1 NM_003564.1 TNXB Tenascin-X precursor TENX_HUMAN P22105 NP_061978.6 NP_115859.2 NM_019105.6 NM_032470.3 CLEC3B Tetranectin precursor TETN_HUMAN P05452 NP_003269.2 NM_003278.2 TLN1 Talin-1 TLN1_HUMAN Q9Y490 NP_006280.3 NM_006289.3 THBS1 Thrombospondin-1 TSP1_HUMAN P07996 NP_003237.2 precursor NM_003246.2 VASN Vasorin precursor VASN_HUMAN Q6EMK4 NP_612449.2 NM_138440.2 VCAM1 Vascular cell adhesion VCAM1_HUMAN P19320 NP_001069.1 protein 1 precursor NP_001186763.1 NP_542413.1 NM_001078.3 NM_001199834.1 NM_080682.2 VTN Vitronectin precursor VTNC_HUMAN P04004 NP_000629.3 NM_000638.3 VWF von Willebrand factor VWF_HUMAN P04275 NP_000543.2 precursor NM_000552.3 ZYX Zyxin ZYX_HUMAN Q15942 NP_001010972.1 NP_003452.1 NM_001010972.1 NM_003461.4

In one embodiment, the one or more additional markers is selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, PGLYRP2, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS.

In certain aspects of the invention, a single marker (e.g., any one of the markers listed in Table 1) may be used in the methods and compositions of the invention. In one embodiment, the one or more markers is selected from the group consisting of CPB2, GP1BA, GPS, GPX3, PROCR, VWF, ATRN, CD14, DBH, SELL, VCAM1, S100A8, S100A9, CD163, CPN1, FCN3, HIST2H2BE, KNG1, MASP1, MASP2, PROS1, YWHAZ, CA1, ORM1, PDLIM1, PGLYRP2, LCAT, LPA, PCSK9, PON1, PTGDS, APOA1, APOA4, APOC1, APOC3, APOE, ANPEP, BCHE, BTD, CDHS, CLEC3B, CLU, CNTN1, ECM1, GPLD1, HABP2, HGFAC, HYOU1, IGFALS, IGFBP3, IGFBP6, LCP1, LGALS3BP, LUM, MINPP1, MST1, NCAM1, NID1, PEPD, PFN1, PRG4, QSOX1, SEPP1, SHBG, SPARC, TGFBI, THBS1, TLN1, TNXB, VASN, VTN, YWHAE, CA2, CKM, CNDP1, COMP, IGF2, LRG1, PI16, PRDX2, PTPRG, SPP2, TAGLN2, ZYX, MTB81, MTB51, CACNA2D1, CPN2, and MAN1A1.

In one embodiment, the markers is selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, PGLYRP2, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS.

In one embodiment, the subject is HIV− and the marker for use in the methods and compositions of the invention is APOE. In one embodiment, the subject is HIV− and the marker is SELL. In one embodiment, the subject is HIV− and the marker is TNXB. In one embodiment, the subject is HIV− and the marker is COMP. In one embodiment, the subject is HIV− and the marker is LUM. In one embodiment, the subject is HIV− and the marker is PGLYRP2. In one embodiment, the subject is HIV− and the marker is HABP2. In one embodiment, the subject is HIV− and the marker is LRG1. In one embodiment, the subject is HIV− and the marker is QSOX1. In one embodiment, the subject is HIV− and the marker is S100A8. In one embodiment, the subject is HIV− and the marker is APOC3. In one embodiment, the subject is HIV− and the marker is CD14. In one embodiment, the subject is HIV− and the marker is SEPP1. In one embodiment, the subject is HIV− and the marker is APOC1. In one embodiment, the subject is HIV− and the marker is PEPD. In one embodiment, the subject is HIV− and the marker is GP1BA. In one embodiment, the subject is HIV+ and the marker is LCP1. In one embodiment, the subject is HIV+ and the marker is VASN. In one embodiment, the subject is HIV+ and the marker is PFN1. In one embodiment, the subject is HIV+ and the marker is IGFBP6. In one embodiment, the subject is HIV+ and the marker is LRG1. In one embodiment, the subject is HIV+ and the marker is PGLYRP2. In one embodiment, the subject is HIV+ and the marker is APOA4. In one embodiment, the subject is HIV+ and the marker is BCHE. In one embodiment, the subject is HIV+ and the marker is PI16. In one embodiment, the subject is HIV+ and the marker is SEPP1. In one embodiment, the subject is HIV+ and the marker is APOA1. In one embodiment, the subject is HIV+ and the marker is IGFALS. In one embodiment, the subject is HIV+ and the marker is CD14. In one embodiment, the subject is HIV+ and the marker is TAGLN2. In one embodiment, the subject is HIV+ and the marker is PTGDS. In one embodiment, the subject is HIV+ and the marker is CPN2.

In some embodiments, the methods may further comprise determining the level of a marker selected from the group consisting of the markers listed in Table 1. In other embodiments, the methods may further comprise determining the level of one or more markers selected from the group consisting of CPB2, GP1BA, GPS, GPX3, PROCR, VWF, ATRN, CD14, DBH, SELL, VCAM1, S100A8, S100A9, CD163, CPN1, FCN3, HIST2H2BE, KNG1, MASP1, MASP2, PROS1, YWHAZ, CA1, ORM1, PDLIM1, PGLYRP2, LCAT, LPA, PCSK9, PON1, PTGDS, APOA1, APOA4, APOC1, APOC3, APOE, ANPEP, BCHE, BTD, CDHS, CLEC3B, CLU, CNTN1, ECM1, GPLD1, HABP2, HGFAC, HYOU1, IGFALS, IGFBP3, IGFBP6, LCP1, LGALS3BP, LUM, MINPP1, MST1, NCAM1, NID1, PEPD, PFN1, PRG4, QSOX1, SEPP1, SHBG, SPARC, TGFBI, THBS1, TLN1, TNXB, VASN, VTN, YWHAE, CA2, CKM, CNDP1, COMP, IGF2, LRG1, PI16, PRDX2, PTPRG, SPP2, TAGLN2, ZYX, MTB81, MTB51, CACNA2D1, CPN2, and MAN1A1.

In other aspects of the invention, more than one marker, e.g., a plurality of markers, e.g., two, three, four, five, six, seven, eight, nine, ten, eleven, or more markers, may be used in the methods and compositions of the invention. For example, in one embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 3. In one embodiment, the subject is HIV−. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 4. In one embodiment, the subject is HIV+. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 6. In one embodiment, the subject is HIV−. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 7. In one embodiment, the subject is HIV−. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 8. In one embodiment, the subject is HIV−. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 10. In one embodiment, the subject is HIV+. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 11. In one embodiment, the subject is HIV+. In another embodiment, the combination of markers suitable for use in the methods and compositions of the invention include one of the combination of markers set forth in Table 12. In one embodiment, the subject is HIV+.

In one embodiment, the subject is HIV− and the markers for use in the methods and compositions of the invention include CD14 and APOE. In one embodiment, the subject is HIV− and the markers include PEPD and SELL. In one embodiment, the subject is HIV− and the markers include CD14, APOE, and SELL. In one embodiment, the subject is HIV− and the markers include PEPD, TNXB, and SELL. In one embodiment, the subject is HIV− and the markers include PEPD, COMP, and SELL. In one embodiment, the subject is HIV− and the markers include PEPD, QSOX1, and SELL. In one embodiment, the subject is HIV− and the markers include PEPD, CD14, and SELL. In one embodiment, the subject is HIV− and the markers include PEPD, SEPP1, and SELL. In one embodiment, the subject is HIV− and the markers include PEPD, LUM, and SELL. In one embodiment, the subject is HIV− and the markers include SELL, SEPP1, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, QSOX1, and SELL. In one embodiment, the subject is HIV− and the markers include TNXB, QSOX1, and SELL. In one embodiment, the subject is HIV− and the markers include COMP, SEPP1, and SELL. In one embodiment, the subject is HIV− and the markers include LUM, SEPP1, and SELL. In one embodiment, the subject is HIV− and the markers include SEPP1, QSOX1, and SELL. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, and PEPD. In one embodiment, the subject is HIV− and the markers include APOC1, COMP, and SELL. In one embodiment, the subject is HIV− and the markers include APOC1, QSOX1, and CD14. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, and SELL. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and COMP. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and PGLYRP2. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and HABP2. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and LRG1. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include CD14, APOE, SELL, and S100A8. In one embodiment, the subject is HIV− and the markers include CD14, APOE, and APOC3. In one embodiment, the subject is HIV− and the markers include CD14, APOE, APOC3, and PGLYRP2. In one embodiment, the subject is HIV− and the markers include CD14, APOE, APOC3, and SELL. In one embodiment, the subject is HIV− and the markers include CD14, APOE, APOC3, and HABP2. In one embodiment, the subject is HIV− and the markers include GP1BA, PEPD, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include COMP, PEPD, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include COMP, PEPD, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include COMP, PEPD, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include CD14, PEPD, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include CD14, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, PEPD, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include COMP, PEPD, SELL, and GP1BA. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and COMP. In one embodiment, the subject is HIV− and the markers include LUM, PEPD, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and CD14. In one embodiment, the subject is HIV− and the markers include COMP, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include QSOX1, PEPD, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include LUM, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, PEPD, SELL, and COMP. In one embodiment, the subject is HIV− and the markers include TNXB, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, PEPD, SELL, and GP1BA. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include QSOX1, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, PEPD, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include LUM, PEPD, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include APOC1, COMP, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include GP1BA, PEPD, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, COMP, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include APOC1, QSOX1, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, LUM, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include CD14, GP1BA, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include GP1BA, PEPD, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include APOC1, QSOX1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include GP1BA, PEPD, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include QSOX1, TNXB, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include LUM, QSOX1, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include COMP, GP1BA, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, SELL, and GP1BA. In one embodiment, the subject is HIV− and the markers include COMP, QSOX1, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include COMP, LUM, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, QSOX1, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include COMP, TNXB, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, APOC1, GP1BA, and QSOX1. In one embodiment, the subject is HIV− and the markers include CD14, QSOX1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, TNXB, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, GP1BA, SELL, and QSOX1. In one embodiment, the subject is HIV− and the markers include APOC1, PEPD, CD14, and GP1BA. In one embodiment, the subject is HIV− and the markers include CD14, COMP, SELL, and GP1BA. In one embodiment, the subject is HIV− and the markers include CD14, APOC1, GP1BA, and TNXB. In one embodiment, the subject is HIV− and the markers include CD14, APOC1, COMP, and GP1BA. In one embodiment, the subject is HIV− and the markers include COMP, QSOX1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include GP1BA, QSOX1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include LUM, QSOX1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include GP1BA, QSOX1, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, LUM, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, GP1BA, and LUM. In one embodiment, the subject is HIV− and the markers include GP1BA, SEPP1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include CD14, LUM, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include COMP, CD14, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include CD14, SEPP1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include GP1BA, LUM, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include CD14, COMP, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include LUM, SEPP1, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include CD14, GP1BA, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, GP1BA, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include APOC1, COMP, SELL, and GP1BA. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, SELL, and COMP. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, PEPD, and LUM. In one embodiment, the subject is HIV− and the markers include COMP, TNXB, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include GP1BA, CD14, SELL, and SEPP1. In one embodiment, the subject is HIV− and the markers include TNXB, CD14, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include GP1BA, CD14, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include APOC1, COMP, SELL, and LUM. In one embodiment, the subject is HIV− and the markers include APOC1, COMP, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include COMP, CD14, GP1BA, and SEPP1. In one embodiment, the subject is HIV− and the markers include GP1BA, CD14, SEPP1, and LUM. In one embodiment, the subject is HIV− and the markers include GP1BA, CD14, SEPP1, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, QSOX1, and SEPP1. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, COMP, and PEPD. In one embodiment, the subject is HIV− and the markers include COMP, GP1BA, SELL, and TNXB. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, QSOX1, and LUM. In one embodiment, the subject is HIV− and the markers include APOC1, CD14, PEPD, and TNXB. In one embodiment, the subject is HIV+ and the markers include LCP1 and VASN. In one embodiment, the subject is HIV+ and the markers include LCP1 and PFN1. In one embodiment, the subject is HIV+ and the markers include VASN and PFN1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, and PFN1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, PGLYRP2, and PFN1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, and IGFBP6. In one embodiment, the subject is HIV+ and the markers include CD14, PGLYRP2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, VASN, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include VASN, PGLYRP2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include VASN, PGLYRP2, and PFN1. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, and PFN1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PFN1, and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, IGFBP6, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PFN1, and IGFBP6. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PFN1, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PGLYRP2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PFN1, and SEPP1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PFN1, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, VASN, IGFBP6, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, SEPP1, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, VASN, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CPN2, PGLYRP2, VASN, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, IGFBP6, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, IGFBP6, and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, IGFBP6, and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, PGLYRP2, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, PGLYRP2, IGFBP6, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, IGFBP6, and SEPP1. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, PGLYRP2, and SEPP1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, IGFBP6, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, PGLYRP2, TAGLN2, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, PGLYRP2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, IGFBP6, and SEPP1. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, TAGLN2, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, SEPP1, IGFBP6, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include PGLYRP2, PFN1, IGFBP6, and VASN. In one embodiment, the subject is HIV+ and the markers include CPN2, PFN1, PGLYRP2, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, PGLYRP2, SEPP1, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CPN2, PFN1, IGFBP6, and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, IGFBP6, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CPN2, PFN1, PGLYRP2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include CD14, PFN1, SEPP1, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, SEPP1, TAGLN2, and VASN. In one embodiment, the subject is HIV+ and the markers include CPN2, PGLYRP2, IGFBP6, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include PGLYRP2, PFN1, TAGLN2, and VASN. In one embodiment, the subject is HIV+ and the markers include PGLYRP2, PFN1, SEPP1, and VASN. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PGLYRP2, and SEPP1. In one embodiment, the subject is HIV+ and the markers include CD14, CPN2, PGLYRP2, and VASN. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and IGFBP6. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and LRG1. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and APOA4. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and BCHE. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and PI16. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and SEPP1. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and APOA1. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and IGFALS. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and CD14. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PFN1, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include LCP1 and TAGLN2. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, TAGLN2, and IGFBP6. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, TAGLN2, and LRG1. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, TAGLN2, and SEPP1. In one embodiment, the subject is HIV+ and the markers include LCP1 and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, and PGLYRP2. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PGLYRP2, and PFN1. In one embodiment, the subject is HIV+ and the markers include LCP1, VASN, PGLYRP2, and TAGLN2. In one embodiment, the subject is HIV+ and the markers include PFN1 and PI16. In one embodiment, the subject is HIV+ and the markers include PFN1 and PON1. In one embodiment, the subject is HIV+ and the markers include PFN1 and PTGDS. In one embodiment, the subject is HIV+ and the markers include PI16 and PON1. In one embodiment, the subject is HIV+ and the markers include PI16 and PTGDS. In one embodiment, the subject is HIV+ and the markers include PON1 and PTGDS. In one embodiment, the subject is HIV+ and the markers include PFN1, PI16, and PON1. In one embodiment, the subject is HIV+ and the markers include PFN1, PI16, and PTGDS. In one embodiment, the subject is HIV+ and the markers include PI16, PON1, and PTGDS. In one embodiment, the subject is HIV+ and the markers include PFN1, PI16, PON1, and PTGDS.

In some embodiments, the methods may further comprise determining the level of a marker selected from the group consisting of the markers listed in Table 1. In other embodiments, the methods may further comprise determining the level of a further comprise determining the level of one or more markers selected from the group consisting of CPB2, GP1BA, GPS, GPX3, PROCR, VWF, ATRN, CD14, DBH, SELL, VCAM1, S100A8, S100A9, CD163, CPN1, FCN3, HIST2H2BE, KNG1, MASP1, MASP2, PROS1, YWHAZ, CA1, ORM1, PDLIM1, PGLYRP2, LCAT, LPA, PCSK9, PON1, PTGDS, APOA1, APOA4, APOC1, APOC3, APOE, ANPEP, BCHE, BTD, CDHS, CLEC3B, CLU, CNTN1, ECM1, GPLD1, HABP2, HGFAC, HYOU1, IGFALS, IGFBP3, IGFBP6, LCP1, LGALS3BP, LUM, MINPP1, MST1, NCAM1, NID1, PEPD, PFN1, PRG4, QSOX1, SEPP1, SHBG, SPARC, TGFBI, THBS1, TLN1, TNXB, VASN, VTN, YWHAE, CA2, CKM, CNDP1, COMP, IGF2, LRG1, PI16, PRDX2, PTPRG, SPP2, TAGLN2, ZYX, MTB81, MTB51, CACNA2D1, CPN2, and MAN1A1.

III. Methods of the Invention

A. Diagnostic Methods

In certain aspects, the present invention provides diagnostic methods. For example, in one aspect, the present invention provides methods for determining whether a subject has active tuberculosis (TB). The methods include determining the level of one or more markers of the invention in a sample(s) from the subject with a level of the one or more markers in a control sample(s). A difference in the level (e.g., higher or lower) of the one or more markers in the sample(s) from the subject as compared to the level of the one or more markers in the control sample indicates that the subject has active TB.

The methods of the present invention can be practiced in conjunction with any other method(s) used by the skilled practitioner to diagnose, prognose, and/or monitor TB. For example, the methods of the invention may be performed in conjunction with any clinical measurement of TB known in the art including serological, cytological and/or detection (and quantification, if appropriate) of other molecular markers. In one embodiment, the methods of the invention are practiced in conjunction with an HIV test.

In any of the methods (and kits) of the invention, the level of a marker(s) of the invention in a sample obtained from a subject may be determined by any of a wide variety of well-known techniques and methods, which transform a marker of the invention within the sample into a moiety that can be detected and quantified. Non-limiting examples of such methods include analyzing the sample using immunological methods for detection of proteins, protein purification methods, protein function or activity assays, nucleic acid hybridization methods, nucleic acid reverse transcription methods, and nucleic acid amplification methods, immunoblotting, Western blotting, Northern blotting, electron microscopy, mass spectrometry, e.g., MALDI-TOF and SELDI-TOF, immunoprecipitations, immunofluorescence, immunohistochemistry, enzyme linked immunosorbent assays (ELISAs), e.g., amplified ELISA, quantitative blood based assays, e.g., serum ELISA, quantitative urine based assays, flow cytometry, Southern hybridizations, array analysis, and the like, and combinations or sub-combinations thereof.

For example, an mRNA sample may be obtained from the sample from the subject (e.g., blood, serum, bronchial lavage, mouth swab, biopsy, or peripheral blood mononuclear cells, by standard methods) and expression of mRNA(s) encoding a marker of the invention in the sample may be detected and/or determined using standard molecular biology techniques, such as PCR analysis. A preferred method of PCR analysis is reverse transcriptase-polymerase chain reaction (RT-PCR). Other suitable systems for mRNA sample analysis include microarray analysis (e.g., using Affymetrix's microarray system or Illumina's BeadArray Technology).

It will be readily understood by the ordinarily skilled artisan that essentially any technical means established in the art for detecting the level a marker of the invention at either the nucleic acid or protein level, can be used to determine the level a marker of the invention as discussed herein.

In one embodiment, the level of a marker of the invention in a sample is determined by detecting a transcribed polynucleotide, or portion thereof, e.g., mRNA, or cDNA, of a marker of the invention gene. RNA may be extracted from cells using RNA extraction techniques including, for example, using acid phenol/guanidine isothiocyanate extraction (RNAzol B; Biogenesis), RNeasy RNA preparation kits (Qiagen) or PAXgene (PreAnalytix, Switzerland). Typical assay formats utilizing ribonucleic acid hybridization include nuclear run-on assays, RT-PCR, RNase protection assays (Melton et al., Nuc. Acids Res. 12:7035), Northern blotting, in situ hybridization, and microarray analysis.

In one embodiment, the level of a marker of the invention is determined using a nucleic acid probe. The term “probe”, as used herein, refers to any molecule that is capable of selectively binding to a specific marker of the invention. Probes can be synthesized by one of skill in the art, or derived from appropriate biological preparations. Probes may be specifically designed to be labeled. Examples of molecules that can be utilized as probes include, but are not limited to, RNA, DNA, proteins, antibodies, and organic molecules.

Isolated mRNA can be used in hybridization or amplification assays that include, but are not limited to, Southern or Northern analyses, polymerase chain reaction (PCR) analyses and probe arrays. One method for the determination of mRNA levels involves contacting the isolated mRNA with a nucleic acid molecule (probe) that can hybridize to a marker mRNA. The nucleic acid probe can be, for example, a full-length cDNA, or a portion thereof, such as an oligonucleotide of at least about 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 100, 250 or about 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to marker genomic DNA.

In one embodiment, the mRNA is immobilized on a solid surface and contacted with a probe, for example by running the isolated mRNA on an agarose gel and transferring the mRNA from the gel to a membrane, such as nitrocellulose. In an alternative embodiment, the probe(s) are immobilized on a solid surface and the mRNA is contacted with the probe(s), for example, in an Affymetrix gene chip array. A skilled artisan can readily adapt known mRNA detection methods for use in determining the level of a marker of the invention mRNA.

An alternative method for determining the level of a marker of the invention in a sample involves the process of nucleic acid amplification and/or reverse transcriptase (to prepare cDNA) of for example mRNA in the sample, e.g., by RT-PCR (the experimental embodiment set forth in Mullis, 1987, U.S. Pat. No. 4,683,202), ligase chain reaction (Barany (1991) Proc. Natl. Acad. Sci. USA 88:189-193), self-sustained sequence replication (Guatelli et al. (1990) Proc. Natl. Acad. Sci. USA 87:1874-1878), transcriptional amplification system (Kwoh et al. (1989) Proc. Natl. Acad. Sci. USA 86:1173-1177), Q-Beta Replicase (Lizardi et al. (1988) Bio/Technology 6:1197), rolling circle replication (Lizardi et al., U.S. Pat. No. 5,854,033) or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers. In particular aspects of the invention, the level of expression of a marker of the invention is determined by quantitative fluorogenic RT-PCR (i.e., the TaqMan™ System). Such methods typically utilize pairs of oligonucleotide primers that are specific for a marker of the invention. Methods for designing oligonucleotide primers specific for a known sequence are well known in the art.

The level of a marker of the invention mRNA may be monitored using a membrane blot (such as used in hybridization analysis such as Northern, Southern, dot, and the like), or microwells, sample tubes, gels, beads or fibers (or any solid support comprising bound nucleic acids). See U.S. Pat. Nos. 5,770,722, 5,874,219, 5,744,305, 5,677,195 and 5,445,934, which are incorporated herein by reference. The determination of a level of a marker of the invention may also comprise using nucleic acid probes in solution.

In one embodiment of the invention, microarrays are used to detect the level of a marker of the invention. Microarrays are particularly well suited for this purpose because of the reproducibility between different experiments. DNA microarrays provide one method for the simultaneous measurement of the levels of large numbers of genes. Each array consists of a reproducible pattern of capture probes attached to a solid support. Labeled RNA or DNA is hybridized to complementary probes on the array and then detected by laser scanning. Hybridization intensities for each probe on the array are determined and converted to a quantitative value representing relative gene expression levels. See, e.g., U.S. Pat. Nos. 6,040,138, 5,800,992 and 6,020,135, 6,033,860, and 6,344,316, which are incorporated herein by reference. High-density oligonucleotide arrays are particularly useful for determining the gene expression profile for a large number of RNA's in a sample.

In certain situations it may be possible to assay for the level of a marker of the invention at the protein level, using a detection reagent that detects the protein product encoded by the mRNA of a marker of the invention. For example, if an antibody reagent is available that binds specifically to a marker of the invention protein product to be detected, and not to other proteins, then such an antibody reagent can be used to detect the expression of a marker of the invention in a cellular sample from the subject, or a preparation derived from the cellular sample, using standard antibody-based techniques known in the art, such as FACS analysis, and the like.

Other known methods for detecting a marker of the invention at the protein level include methods such as electrophoresis, capillary electrophoresis, high performance liquid chromatography (HPLC), thin layer chromatography (TLC), hyperdiffusion chromatography, and the like, or various immunological methods such as fluid or gel precipitin reactions, immunodiffusion (single or double), immunoelectrophoresis, radioimmunoassay (RIA), enzyme-linked immunosorbent assays (ELISAs), immunofluorescent assays, and Western blotting.

Proteins from samples can be isolated using techniques that are well known to those of skill in the art. The protein isolation methods employed can, for example, be those described in Harlow and Lane (Harlow and Lane, 1988, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York).

In one embodiment, antibodies, or antibody fragments, are used in methods such as Western blots or immunofluorescence techniques to detect the expressed proteins. Antibodies for determining the expression of a marker of the invention are commercially available and one of ordinary skill in the art can readily identify appropriate antibodies for use in the methods of the invention.

It is generally preferable to immobilize either the antibody or proteins on a solid support for Western blots and immunofluorescence techniques. Suitable solid phase supports or carriers include any support capable of binding an antigen or an antibody. Well-known supports or carriers include glass, polystyrene, polypropylene, polyethylene, dextran, nylon, amylases, natural and modified celluloses, polyacrylamides, gabbros, and magnetite.

One skilled in the art will know many other suitable carriers for binding antibody or antigen, and will be able to adapt such support for use with the present invention. For example, protein isolated from cells can be run on a polyacrylamide gel electrophoresis and immobilized onto a solid phase support such as nitrocellulose. The support can then be washed with suitable buffers followed by treatment with the detectably labeled antibody. The solid phase support can then be washed with the buffer a second time to remove unbound antibody. The amount of bound label on the solid support can then be detected by conventional means. Means of detecting proteins using electrophoretic techniques are well known to those of skill in the art (see generally, R. Scopes (1982) Protein Purification, Springer-Verlag, N.Y.; Deutscher, (1990) Methods in Enzymology Vol. 182: Guide to Protein Purification, Academic Press, Inc., N.Y.).

Other standard methods include immunoassay techniques which are well known to one of ordinary skill in the art and may be found in Principles And Practice Of Immunoassay, 2nd Edition, Price and Newman, eds., MacMillan (1997) and Antibodies, A Laboratory Manual, Harlow and Lane, eds., Cold Spring Harbor Laboratory, Ch. 9 (1988), each of which is incorporated herein by reference in its entirety.

Antibodies used in immunoassays to determine the level of a marker of the invention, may be labeled with a detectable label. The term “labeled”, with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a fluorescently labeled secondary antibody and end-labeling of a DNA probe with biotin such that it can be detected with fluorescently labeled streptavidin.

In one embodiment, the antibody is labeled, e.g. a radio-labeled, chromophore-labeled, fluorophore-labeled, or enzyme-labeled antibody. In another embodiment, an antibody derivative (e.g. an antibody conjugated with a substrate or with the protein or ligand of a protein-ligand pair {e.g. biotin-streptavidin}), or an antibody fragment (e.g. a single-chain antibody, an isolated antibody hypervariable domain, etc.) which binds specifically with a marker of the invention.

In one embodiment of the invention, proteomic methods, e.g., mass spectrometry, are used to determine the level of a marker of the invention. Mass spectrometry is an analytical technique that consists of ionizing chemical compounds to generate charged molecules (or fragments thereof) and measuring their mass-to-charge ratios. In a typical mass spectrometry procedure, a sample is obtained from a subject, loaded onto the mass spectrometry, and its components (e.g., a marker of the invention) are ionized by different methods (e.g., by impacting them with an electron beam), resulting in the formation of charged particles (ions). The mass-to-charge ratio of the particles is then calculated from the motion of the ions as they transit through electromagnetic fields.

For example, matrix-associated laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) or surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) which involves the application of a biological sample, such as serum, to a protein-binding chip (Wright, G. L., Jr., et al. (2002) Expert Rev Mol Diagn 2:549; Li, J., et al. (2002) Clin Chem 48:1296; Laronga, C., et al. (2003) Dis Markers 19:229; Petricoin, E. F., et al. (2002) 359:572; Adam, B. L., et al. (2002) Cancer Res 62:3609; Tolson, J., et al. (2004) Lab Invest 84:845; Xiao, Z., et al. (2001) Cancer Res 61:6029) can be used to determine the level of a marker of the invention.

Furthermore, in vivo techniques for determination of the level of a marker of the invention include introducing into a subject a labeled antibody directed against a marker of the invention, which binds to and transforms a marker of the invention into a detectable molecule. As discussed above, the presence, level, or even location of the detectable marker of the invention in a subject may be detected determined by standard imaging techniques.

In general, it is preferable that the difference between the level of a marker of the invention in a sample from a subject and the amount of a marker of the invention in a control sample, is as great as possible. Although this difference can be as small as the limit of detection of the method for determining the level of a marker it is preferred that the difference be at least greater than the standard error of the assessment method, and preferably a difference of at least 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 15-, 20-, 25-, 100-, 500-, 1000-fold or greater than the standard error of the assessment method.

B. Methods for Monitoring the Effectiveness of a Treatment

The present invention also provides methods for monitoring the effectiveness of a therapy or treatment regimen or any other therapeutic approach useful for treating a subject having active TB and/or inhibiting the progression of TB to disseminated TB (or a complication associated with disseminated TB (e.g., spinal and kidney meningitis, peritonitis, pericarditis, bone and joint complications, fallopian tube infection, bowel infection, Adult respiratory distress syndrome (ARDS), liver inflammation, lung failure, and/or relapse of the disease) in a subject having TB.

In these methods the level of one or more markers of the invention in a pair of samples (a first sample not subjected to the treatment regimen and a second sample subjected to at least a portion of the treatment regimen) is assessed. A modulation in the level of expression of the one or more markers in the first sample, relative to the second sample, is an indication that the therapy is effective for for treating a subject having active TB and/or inhibiting the progression of TB to disseminated TB (or a complication associated with disseminated TB (e.g., spinal and kidney meningitis, peritonitis, pericarditis, bone and joint complications, fallopian tube infection, bowel infection, Adult respiratory distress syndrome (ARDS), liver inflammation, lung failure, and/or relapse of the disease) in a subject having TB.

C. Screening Methods

Using the methods described herein, a variety of molecules, particularly molecules sufficiently small to be able to cross the cell membrane, may be screened in order to identify molecules which modulate, e.g., decrease or increase, the level and/or activity of a marker(s) of the invention. Compounds so identified can be administered to a subject in order to for treating a subject having active TB and/or inhibiting the progression of TB to disseminated TB (or a complication associated with disseminated TB (e.g., spinal and kidney meningitis, peritonitis, pericarditis, bone and joint complications, fallopian tube infection, bowel infection, Adult respiratory distress syndrome (ARDS), liver inflammation, lung failure, and/or relapse of the disease) in a subject having TB.

Accordingly, in one embodiment, the invention provides methods for identifying modulators, i.e., candidate or test compounds or agents (e.g., enzymes, peptides, peptidomimetics, small molecules, ribozymes, or marker antisense molecules) which bind to a marker polypeptide; have a stimulatory or inhibitory effect on a marker expression; marker processing; marker post-translational modification (e.g., glycosylation, ubiquitinization, or phosphorylation); marker activity; and/or have a stimulatory or inhibitory effect on the expression, processing or activity of a marker target molecule.

Methods for identifying a compound that can modulate the level and/or activity of a marker in a cell (in vitro and/or in vivo), for treating a subject having active TB and/or inhibiting the progression of TB to disseminated TB (or a complication associated with disseminated TB) (also referred to herein as screening assays) include separately contacting an aliquot of a sample (e.g., a sample from the subject) with each member of a library of compounds; determining the effect of a member of the library of compounds on the level of one or more marker(s) of the invention (and/or the activity of one or more marker(s) of the invention) in each of the aliquots; and selecting a member of the library of compounds which modulates the level of and/or the activity of the one or more marker(s) of the invention in an aliquot as compared to the level and/or activity of the one or more marker(s) of the invention in a control sample, thereby identifying a compound that can modulate the level and/or activity of a marker in a cell, for treating a subject having active TB and/or inhibiting the progression of pulmonary TB to disseminated TB (or a complication associated with disseminated TB).

As used interchangeably herein, the terms “marker activity” and “biological activity of a marker” include activities exerted by a marker(s) protein on marker responsive cell or tissue, or on marker(s) nucleic acid molecule or protein target molecule, as determined in vivo, and/or in vitro, according to standard techniques. A marker(s) activity can be a direct activity, such as an association with a marker-target molecule. Alternatively, a marker(s) activity is an indirect activity, such as a downstream biological event mediated by interaction of the marker(s) protein with a marker-target molecule or other molecule in a signal-transduction pathway involving the marker(s). The biological activities of the markers of the invention are known in the art and can be found at, for example, www.uniprot.org. The Uniprot Accession Numbers for each of the markers of the invention are provided in Table 1. The entire contents of each of these Uniprot records are hereby incorporated by reference. Methods for determining the effect of a compound on the level and/or activity of marker are known in the art and/or described herein.

A variety of test compounds can be evaluated using the screening assays described herein. The term “test compound” includes any reagent or test agent which is employed in the assays of the invention and assayed for its ability to influence the expression and/or activity of a marker. More than one compound, e.g., a plurality of compounds, can be tested at the same time for their ability to modulate the expression and/or activity of a marker in a screening assay. The term “screening assay” preferably refers to assays which test the ability of a plurality of compounds to influence the readout of choice rather than to tests which test the ability of one compound to influence a readout. Preferably, the subject assays identify compounds not previously known to have the effect that is being screened for. In one embodiment, high throughput screening can be used to assay for the activity of a compound.

Candidate/test compounds include, for example, 1) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam, K. S. et al. (1991) Nature 354:82-84; Houghten, R. et al. (1991) Nature 354:84-86) and combinatorial chemistry-derived molecular libraries made of D- and/or L-configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang, Z. et al. (1993) Cell 72:767-778); 3) antibodies (e.g., polyclonal, monoclonal, humanized, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab′)2, Fab expression library fragments, and epitope-binding fragments of antibodies); 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries); 5) enzymes (e.g., endoribonucleases, hydrolases, nucleases, proteases, synthatases, isomerases, polymerases, kinases, phosphatases, oxido-reductases and ATPases), 6) mutant forms of marker(s) molecules, e.g., dominant negative mutant forms of the molecules, 7) nucleic acids, 8) carbohydrates, and 9) natural product extract compounds.

Test compounds can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the ‘one-bead one-compound’ library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, K. S. (1997) Anticancer Drug Des. 12:145).

Examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt et al. (1993) Proc. Natl. Acad. Sci. U.S.A. 90:6909; Erb et al. (1994) Proc. Natl. Acad. Sci. USA 91:11422; Zuckermann et al. (1994) J. Med. Chem. 37:2678; Cho et al. (1993) Science 261:1303; Carrell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2059; Carell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2061; and Gallop et al. (1994) J. Med. Chem. 37:1233. Libraries of compounds can be presented in solution (e.g., Houghten (1992)

Biotechniques 13:412-421), or on beads (Lam (1991) Nature 354:82-84), chips (Fodor (1993) Nature 364:555-556), bacteria (Ladner U.S. Pat. No. 5,223,409), spores (Ladner USP '409), plasmids (Cull et al. (1992) Proc Natl Acad Sci USA 89:1865-1869) or phage (Scott and Smith (1990) Science 249:386-390; Devlin (1990) Science 249:404-406; Cwirla et al. (1990) Proc. Natl. Acad. Sci. 87:6378-6382; Felici (1991) J. Mol. Biol. 222:301-310; Ladner supra.).

Compounds identified in the screening assays can be used in methods of modulating one or more of the biological responses regulated by a marker. It will be understood that it may be desirable to formulate such compound(s) as pharmaceutical compositions prior to contacting them with cells.

Once a test compound is identified by one of the variety of methods described hereinbefore, the selected test compound (or “compound of interest”) can then be further evaluated for its effect on cells, for example by contacting the compound of interest with cells either in vivo (e.g., by administering the compound of interest to a subject or animal model) or ex vivo (e.g., by isolating cells from the subject or animal model and contacting the isolated cells with the compound of interest or, alternatively, by contacting the compound of interest with a cell line) and determining the effect of the compound of interest on the cells, as compared to an appropriate control (such as untreated cells or cells treated with a control compound, or carrier, that does not modulate the biological response).

Computer-based analysis of a marker with a known structure can also be used to identify molecules which will bind to a marker of the invention. Such methods rank molecules based on their shape complementary to a receptor site. For example, using a 3-D database, a program such as DOCK can be used to identify molecules which will bind. See DesJarlias et al. (1988) J. Med. Chem. 31:722; Meng et al. (1992) J. Computer Chem. 13:505; Meng et al. (1993) Proteins 17:266; Shoichet et al. (1993) Science 259:1445. In addition, the electronic complementarity of a molecule to a marker can be analyzed to identify molecules which bind to the marker. This can be determined using, for example, a molecular mechanics force field as described in Meng et al. (1992) J. Computer Chem. 13:505 and Meng et al. (1993) Proteins 17:266. Other programs which can be used include CLIX which uses a GRID force field in docking of putative ligands. See Lawrence et al. (1992) Proteins 12:31; Goodford et al. (1985) J. Med. Chem. 28:849; Boobbyer et al. (1989) J. Med. Chem. 32:1083.

The instant invention also pertains to compounds identified using the foregoing screening assays.

D. Methods for Modulating the Expression and/or Activity of a Biomarker of the Invention

Yet another aspect of the invention pertains to methods of modulating expression and/or activity of a marker in a cell. The modulatory methods of the invention involve contacting the cell with an agent that modulates the expression and/or activity of a marker such that the expression and/or activity of a marker in the cell is modulated. In order for the expression and/or activity of a marker to be modulated in a cell, the cell is contacted with a modulatory agent in an amount sufficient to modulate the expression and/or activity of a marker.

A “modulator” or “modulatory agent” is a compound or molecule that modulates, and may be, e.g., an agonist, antagonist, activator, stimulator, suppressor, or inhibitor. As used herein, the term “modulator” refers to any moiety which modulates activity of a marker(s), including moieties which modulates marker(s) expression or modulates marker(s) function. The modulator may act by modulating the activity of a marker polypeptide in the cell, (e.g., by contacting a cell with an agent that, e.g., interferes with the binding of a marker(s) to a molecule with which it interacts, changes the binding specificity of a marker(s), or post-translationally modifies a marker(s) or the expression of a marker(s), (e.g., by modulating transcription of the marker gene or translation of the marker mRNA). Accordingly, the invention features methods for modulating one or more biological responses regulated by a marker(s) by contacting the cells with a modulator of the expression and/or activity the marker(s) such that the biological response is modulated.

Representative modulators are described below and include, but are not limited to, proteins, nucleic acid molecules, antibodies, nucleic acids (e.g., antisense molecules, such as ribozymes and RNA interfering agents), immunoconjugates (e.g., an antibody conjugated to a therapeutic agent), small molecules, fusion proteins, adnectins, aptamers, anticalins, lipocalins, and marker-derived peptidic compounds.

As used herein, the term “contacting” (e.g., contacting a cell with a modulator) is intended to include incubating the modulator and the cell together in vitro (e.g., adding the modulator to cells in culture) or administering the modulator to a subject such that the modulator and cells of the subject are contacted in vivo. The term “contacting” is not intended to include exposure of cells to an agent that may occur naturally in a subject (i.e., exposure that may occur as a result of a natural physiological process).

In one embodiment, the modulatory methods of the invention are performed in vitro. In another embodiment, the modulatory methods of the invention are performed in vivo, e.g., in a subject, e.g., having active TB, that would benefit from modulation of the expression and/or activity of a marker of the invention.

Accordingly, the present invention also provides methods for treating a subject having active TB and methods for reducing or inhibiting the development of complications associated with the disease in a subject

The methods of “inhibiting”, “slowing”, and/or “treating” include administration of a marker modulator to a subject in order to cure or to prolong the health or survival of a subject beyond that expected in the absence of such treatment.

The terms “patient” or “subject” as used herein is intended to include human and veterinary patients. In a particular embodiment, the subject is a human. The term “non-human animal” includes all vertebrates, e.g., mammals and non-mammals, such as non-human primates, mice, rabbits, sheep, dog, cow, chickens, amphibians, and reptiles.

The methods of the invention also contemplate the use of marker(s) modulators in combination with other therapies, including life-style changes. Thus, in addition to the use of marker(s) modulators, the methods of the invention may also include administering to the subject one or more “standard” therapies. For example, the modulators can be administered in combination with (i.e., together with or linked to (i.e., an immunoconjugate)) cytotoxins, immunosuppressive agents, radiotoxic agents, and/or therapeutic antibodies. Particular co-therapeutics contemplated by the present invention include, but are not limited to, Isoniazid, Rifampin (Rifadin, Rimactane), Ethambutol (Myambutol), Pyrazinamide, streptomycin, vitamin D, Clarithromycin, Dapsone, Ofloxacin, Rifabutin, Non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz (Sustiva), etravirine (Intelence) and nevirapine (Viramune, Nucleoside reverse transcriptase inhibitors (NRTIs; e.g., Abacavir (Ziagen), and the combination drugs emtricitabine and tenofovir (Truvada), and lamivudine and zidovudine (Combivir), Protease inhibitors (PIs; e.g., atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva) and ritonavir (Norvir), Entry or fusion inhibitors, e.g., enfuvirtide (Fuzeon) and maraviroc (Selzentry), and Integrase inhibitors, e.g., Raltegravir (Isentress), or combinations thereof.

Marker(s) modulators and the co-therapeutic agent or co-therapy can be administered in the same formulation or separately. In the case of separate administration, the marker(s) modulators can be administered before, after or concurrently with the co-therapeutic or co-therapy. One agent may precede or follow administration of the other agent by intervals ranging from minutes to weeks. In embodiments where two or more different kinds of therapeutic agents are applied separately to a subject, one would generally ensure that a significant period of time did not expire between the time of each delivery, such that these different kinds of agents would still be able to exert an advantageously combined effect on the target tissues or cells.

In one embodiment, the marker(s) modulators (e.g., an anti-marker(s) antibody) may be linked to a second binding molecule, such as an antibody (i.e., thereby forming a bispecific molecule) or other binding agent that, for example, binds to a different target or a different epitope on the marker(s).

The term “effective amount” as used herein, refers to that amount of marker(s) modulators, which is sufficient to treat and/or inhibit the progression of active TB and/or a complication of TB in a subject when administered to a subject. An effective amount will vary depending upon the subject and the severity of the disease and age of the subject, the manner of administration and the like, which can readily be determined by one of ordinary skill in the art. Marker(s) modulators dosages for administration can range from, for example, about 1 ng to about 10,000 mg, about 5 ng to about 9,500 mg, about 10 ng to about 9,000 mg, about 20 ng to about 8,500 mg, about 30 ng to about 7,500 mg, about 40 ng to about 7,000 mg, about 50 ng to about 6,500 mg, about 100 ng to about 6,000 mg, about 200 ng to about 5,500 mg, about 300 ng to about 5,000 mg, about 400 ng to about 4,500 mg, about 500 ng to about 4,000 mg, about 1 μg to about 3,500 mg, about 5 μg to about 3,000 mg, about 10 μg to about 2,600 mg, about 20 μg to about 2,575 mg, about 30 μg to about 2,550 mg, about 40 μg to about 2,500 mg, about 50 μg to about 2,475 mg, about 100 μg to about 2,450 mg, about 200 μg to about 2,425 mg, about 300 μg to about 2,000, about 400 μg to about 1,175 mg, about 500 μg to about 1,150 mg, about 0.5 mg to about 1,125 mg, about 1 mg to about 1,100 mg, about 1.25 mg to about 1,075 mg, about 1.5 mg to about 1,050 mg, about 2.0 mg to about 1,025 mg, about 2.5 mg to about 1,000 mg, about 3.0 mg to about 975 mg, about 3.5 mg to about 950 mg, about 4.0 mg to about 925 mg, about 4.5 mg to about 900 mg, about 5 mg to about 875 mg, about 10 mg to about 850 mg, about 20 mg to about 825 mg, about 30 mg to about 800 mg, about 40 mg to about 775 mg, about 50 mg to about 750 mg, about 100 mg to about 725 mg, about 200 mg to about 700 mg, about 300 mg to about 675 mg, about 400 mg to about 650 mg, about 500 mg, or about 525 mg to about 625 mg, of a marker(s) modulator. Dosage regimens may be adjusted to provide the optimum therapeutic response. An effective amount is also one in which any toxic or detrimental effects (i.e., side effects) of a marker(s) modulator are minimized and/or outweighed by the beneficial effects.

Actual dosage levels of the marker(s) modulators used in the methods of the present invention may be varied so as to obtain an amount of the active ingredient which is effective to achieve the desired response, e.g., inhibiting the progression of diabetes, for a particular patient, composition, and mode of administration, without being toxic to the patient. The selected dosage level will depend upon a variety of pharmacokinetic factors including the activity of the particular marker(s) modulator employed, or the ester, salt or amide thereof, the route of administration, the time of administration, the rate of excretion of the particular modulator being employed, the duration of the treatment, other drugs, compounds and/or materials used in combination with the particular modulator employed, the age, sex, weight, condition, general health and prior medical history of the patient being treated, and like factors well known in the medical arts. A physician or veterinarian having ordinary skill in the art can readily determine and prescribe the effective amount of the modulator required. For example, the physician or veterinarian could start doses of the modulator at levels lower than that required in order to achieve the desired therapeutic effect and gradually increase the dosage until the desired effect is achieved. In general, a suitable daily dose of a marker(s) modulator will be that amount which is the lowest dose effective to produce a therapeutic effect. Such an effective dose will generally depend upon the factors described above. It is preferred that administration be intravenous, intramuscular, intraperitoneal, or subcutaneous, preferably administered proximal to the site of the target. If desired, the effective daily dose of a marker(s) modulator may be administered as two, three, four, five, six or more sub-doses administered separately at appropriate intervals throughout the day, optionally, in unit dosage forms. While it is possible for a marker(s) modulator of the present invention to be administered alone, it is preferable to administer the modulator as a pharmaceutical formulation (composition).

Dosage regimens are adjusted to provide the optimum desired response (e.g., a therapeutic response). For example, a single bolus may be administered, several divided doses may be administered over time or the dose may be proportionally reduced or increased as indicated by the exigencies of the therapeutic situation. For example, the marker(s) modulators used in the methods of the present invention may be administered once or twice weekly by subcutaneous injection or once or twice monthly by subcutaneous injection.

To administer a marker(s) modulator used in the methods of the present invention by certain routes of administration, it may be necessary to include the modulator in a formulation suitable for preventing its inactivation. For example, the marker(s) modulator may be administered to a subject in an appropriate carrier, for example, liposomes, or a diluent. Pharmaceutically acceptable diluents include saline and aqueous buffer solutions. Liposomes include water-in-oil-in-water CGF emulsions, as well as conventional liposomes (Strejan et al. (1984) J. Neuroimmunol. 7:27).

Pharmaceutically acceptable carriers include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. The use of such media and agents for pharmaceutically active substances is known in the art. Except insofar as any conventional media or agent is incompatible with the active marker(s) modulator, use thereof in pharmaceutical compositions is contemplated. Supplementary active compounds can also be incorporated with the marker(s) modulator.

Marker(s) modulators used in the methods of the invention typically must be sterile and stable under the conditions of manufacture and storage. The modulator can be formulated as a solution, microemulsion, liposome, or other ordered structure suitable to high drug concentration. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as mannitol, sorbitol, or sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including an agent that delays absorption, for example, monostearate salts and gelatin.

Sterile injectable solutions can be prepared by incorporating the active modulator in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by sterilization microfiltration. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum drying and freeze-drying (lyophilization) that yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.

Marker(s) modulators that can be used in the methods of the present invention include those suitable for oral, nasal, topical (including buccal and sublingual), rectal, vaginal and/or parenteral administration. The formulations may conveniently be presented in unit dosage form and may be prepared by any methods known in the art of pharmacy. The amount of active ingredient which can be combined with a carrier material to produce a single dosage form will vary depending upon the subject being treated, and the particular mode of administration. The amount of active ingredient which can be combined with a carrier material to produce a single dosage form will generally be that amount of the modulator which produces a therapeutic effect. Generally, out of one hundred percent, this amount will range from about 0.001% to about 90% of active ingredient, preferably from about 0.005% to about 70%, most preferably from about 0.01% to about 30%.

The phrases “parenteral administration” and “administered parenterally”, as used herein, means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intraarterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal, epidural and intrasternal injection and infusion.

Examples of suitable aqueous and non-aqueous carriers which may be employed along with the marker(s) modulators utilized in the methods of the present invention include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol, and the like), and suitable mixtures thereof, vegetable oils, such as olive oil, and injectable organic esters, such as ethyl oleate. Proper fluidity can be maintained, for example, by the use of coating materials, such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants.

Marker(s) modulators may also be administered with adjuvants such as preservatives, wetting agents, emulsifying agents and dispersing agents. Prevention of presence of microorganisms may be ensured both by sterilization procedures and by the inclusion of various antibacterial and antifungal agents, for example, paraben, chlorobutanol, phenol sorbic acid, and the like. It may also be desirable to include isotonic agents, such as sugars, sodium chloride, and the like into the compositions. In addition, prolonged absorption of the injectable pharmaceutical form may be brought about by the inclusion of agents which delay absorption such as aluminum monostearate and gelatin.

When marker(s) modulators used in the methods of the present invention are administered to humans and animals, they can be given alone or as a pharmaceutical modulator containing, for example, 0.001 to 90% (more preferably, 0.005 to 70%, such as 0.01 to 30%) of active ingredient in combination with a pharmaceutically acceptable carrier.

Marker(s) modulators can be administered with medical devices known in the art. For example, in a preferred embodiment, a modulator can be administered with a needleless hypodermic injection device, such as the devices disclosed in U.S. Pat. Nos. 5,399,163, 5,383,851, 5,312,335, 5,064,413, 4,941,880, 4,790,824, or 4,596,556. Examples of well-known implants and modules useful in the present invention include: U.S. Pat. No. 4,487,603, which discloses an implantable micro-infusion pump for dispensing medication at a controlled rate; U.S. Pat. No. 4,486,194, which discloses a therapeutic device for administering medications through the skin; U.S. Pat. No. 4,447,233, which discloses a medication infusion pump for delivering medication at a precise infusion rate; U.S. Pat. No. 4,447,224, which discloses a variable flow implantable infusion apparatus for continuous drug delivery; U.S. Pat. No. 4,439,196, which discloses an osmotic drug delivery system having multi-chamber compartments; and U.S. Pat. No. 4,475,196, which discloses an osmotic drug delivery system. Many other such implants, delivery systems, and modules are known to those skilled in the art.

1. Inhibitory Agents

According to a modulatory method of the invention, the expression and/or activity of a marker(s) is inhibited in a cell or subject by contacting the cell with (or administering to a subject) an inhibitory agent. Inhibitory agents of the invention can be, for example, molecules that act to decrease or inhibit the expression and/or activity of the marker(s).

In one embodiment of the invention, the modulatory, e.g., therapeutic, and diagnostic methods described herein employ an antibody that binds, e.g., directly to or indirectly to, and inhibits marker(s) activity and/or down-modulates marker(s) expression.

The term “antibody” or “immunoglobulin,” as used interchangeably herein, includes whole antibodies and any antigen binding fragment (i.e., “antigen-binding portion”) or single chains thereof. An “antibody” comprises at least two heavy (H) chains and two light (L) chains inter-connected by disulfide bonds. Each heavy chain is comprised of a heavy chain variable region (abbreviated herein as VH) and a heavy chain constant region. The heavy chain constant region is comprised of three domains, CH1, CH2 and CH3. Each light chain is comprised of a light chain variable region (abbreviated herein as VL) and a light chain constant region. The light chain constant region is comprised of one domain, CL. The VH and VL regions can be further subdivided into regions of hypervariability, termed complementarity determining regions (CDR), interspersed with regions that are more conserved, termed framework regions (FR). Each VH and VL is composed of three CDRs and four FRs, arranged from amino-terminus to carboxy-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4. The variable regions of the heavy and light chains contain a binding domain that interacts with an antigen. The constant regions of the antibodies may mediate the binding of the immunoglobulin to host tissues or factors, including various cells of the immune system (e.g., effector cells) and the first component (Clq) of the classical complement system.

The term “antigen-binding portion” of an antibody (or simply “antibody portion”), as used herein, refers to one or more fragments of an antibody that retain the ability to specifically bind to an antigen (e.g., a marker). It has been shown that the antigen-binding function of an antibody can be performed by fragments of a full-length antibody. Examples of binding fragments encompassed within the term “antigen-binding portion” of an antibody include (i) a Fab fragment, a monovalent fragment consisting of the VL, VH, CL and CH1 domains; (ii) a F(ab′)2 fragment, a bivalent fragment comprising two Fab fragments linked by a disulfide bridge at the hinge region; (iii) a Fd fragment consisting of the VH and CH1 domains; (iv) a Fv fragment consisting of the VL and VH domains of a single arm of an antibody, (v) a dAb including VH and VL domains; (vi) a dAb fragment (Ward et al. (1989) Nature 341, 544-546), which consists of a VH domain; (vii) a dAb which consists of a VH or a VL domain; and (viii) an isolated complementarity determining region (CDR) or (ix) a combination of two or more isolated CDRs which may optionally be joined by a synthetic linker. Furthermore, although the two domains of the Fv fragment, VL and VH, are coded for by separate genes, they can be joined, using recombinant methods, by a synthetic linker that enables them to be made as a single protein chain in which the VL and VH regions pair to form monovalent molecules (known as single chain Fv (scFv); see e.g., Bird et al. (1988) Science 242, 423-426; and Huston et al. (1988) Proc. Natl. Acad. Sci. USA 85, 5879-5883). Such single chain antibodies are also intended to be encompassed within the term “antigen-binding portion” of an antibody. These antibody fragments are obtained using conventional techniques known to those with skill in the art, and the fragments are screened for utility in the same manner as are intact antibodies. Antigen-binding portions can be produced by recombinant DNA techniques, or by enzymatic or chemical cleavage of intact immunoglobulins.

The term “antibody”, as used herein, includes polyclonal antibodies, monoclonal antibodies, chimeric antibodies, humanized antibodies, and human antibodies, and those that occur naturally or are recombinantly produced according to methods well known in the art.

In one embodiment, an antibody for use in the methods of the invention is a bispecific antibody. A “bispecific” or “bifunctional antibody” is an artificial hybrid antibody having two different heavy/light chain pairs and two different binding sites. Bispecific antibodies can be produced by a variety of methods including fusion of hybridomas or linking of Fab′ fragments. See, e.g., Songsivilai & Lachmann, (1990) Clin. Exp. Immunol. 79, 315-321; Kostelny et al. (1992) J. Immunol. 148, 1547-1553.

In another embodiment, an antibody for use in the methods of the invention is a camelid antibody as described in, for example, PCT Publication WO 94/04678, the entire contents of which are incorporated herein by reference.

A region of the camelid antibody that is the small, single variable domain identified as VHH can be obtained by genetic engineering to yield a small protein having high affinity for a target, resulting in a low molecular weight, antibody-derived protein known as a “camelid nanobody”. See U.S. Pat. No. 5,759,808; see also Stijlemans et al., 2004 J. Biol. Chem. 279: 1256-1261; Dumoulin et al., 2003 Nature 424: 783-788; Pleschberger et al., 2003 Bioconjugate Chem. 14: 440-448; Cortez-Retamozo et al., 2002 Int. J. Cancer 89: 456-62; and Lauwereys, et al., 1998 EMBO J. 17: 3512-3520. Engineered libraries of camelid antibodies and antibody fragments are commercially available, for example, from Ablynx, Ghent, Belgium. Accordingly, a feature of the present invention is a camelid nanobody having high affinity for a marker.

In other embodiments of the invention, an antibody for use in the methods of the invention is a diabody, a single chain diabody, or a di-diabody.

Diabodies are bivalent, bispecific molecules in which VH and VL domains are expressed on a single polypeptide chain, connected by a linker that is too short to allow for pairing between the two domains on the same chain. The VH and VL domains pair with complementary domains of another chain, thereby creating two antigen binding sites (see e.g., Holliger et al., 1993 Proc. Natl. Acad. Sci. USA 90:6444-6448; Poljak et al., 1994 Structure 2:1121-1123). Diabodies can be produced by expressing two polypeptide chains with either the structure VHA-VLB and VHB-VLA (VH-VL configuration), or VLA-VHB and VLB-VHA (VL-VH configuration) within the same cell. Most of them can be expressed in soluble form in bacteria.

Single chain diabodies (scDb) are produced by connecting the two diabody-forming polypeptide chains with linker of approximately 15 amino acid residues (see Holliger and Winter, 1997 Cancer Immunol. Immunother., 45(3-4):128-30; Wu et al., 1996 Immunotechnology, 2(1):21-36). scDb can be expressed in bacteria in soluble, active monomeric form (see Holliger and Winter, 1997 Cancer Immunol. Immunother., 45(34): 128-30; Wu et al., 1996 Immunotechnology, 2(1):21-36; Pluckthun and Pack, 1997 Immunotechnology, 3(2): 83-105; Ridgway et al., 1996 Protein Eng., 9(7):617-21).

A diabody can be fused to Fc to generate a “di-diabody” (see Lu et al., 2004 J. Biol. Chem., 279(4):2856-65).

Marker binding molecules that exhibit functional properties of antibodies but derive their framework and antigen binding portions from other polypeptides (e.g., polypeptides other than those encoded by antibody genes or generated by the recombination of antibody genes in vivo) may also be used in the methods of the present invention. The antigen binding domains (e.g., marker binding domains) of these binding molecules are generated through a directed evolution process. See U.S. Pat. No. 7,115,396. Molecules that have an overall fold similar to that of a variable domain of an antibody (an “immunoglobulin-like” fold) are appropriate scaffold proteins. Scaffold proteins suitable for deriving antigen binding molecules include fibronectin or a fibronectin dimer, tenascin, N-cadherin, E-cadherin, ICAM, titin, GCSF-receptor, cytokine receptor, glycosidase inhibitor, antibiotic chromoprotein, myelin membrane adhesion molecule P0, CD8, CD4, CD2, class I MHC, T-cell antigen receptor, CD1, C2 and I-set domains of VCAM-1, I-set immunoglobulin domain of myosin-binding protein C, I-set immunoglobulin domain of myosin-binding protein H, I-set immunoglobulin domain of telokin, NCAM, twitchin, neuroglian, growth hormone receptor, erythropoietin receptor, prolactin receptor, interferon-gamma receptor, β-galactosidase/glucuronidase, β-glucuronidase, transglutaminase, T-cell antigen receptor, superoxide dismutase, tissue factor domain, cytochrome F, green fluorescent protein, GroEL, and thaumatin.

To generate non-antibody binding molecules, a library of clones is created in which sequences in regions of the scaffold protein that form antigen binding surfaces (e.g., regions analogous in position and structure to CDRs of an antibody variable domain immunoglobulin fold) are randomized. Library clones are tested for specific binding to the antigen of interest (e.g., a marker(s) of the invention) and for other functions (e.g., inhibition of biological activity of a marker(s) of the invention). Selected clones can be used as the basis for further randomization and selection to produce derivatives of higher affinity for the antigen.

High affinity binding molecules are generated, for example, using the tenth module of fibronectin III (10Fn3) as the scaffold, described in U.S. Pat. Nos. 6,818,418 and 7,115,396; Roberts and Szostak, 1997 Proc. Natl. Acad. Sci USA 94:12297; U.S. Pat. No. 6,261,804; U.S. Pat. No. 6,258,558; and Szostak et al. WO98/31700, the entire contents of each of which are incorporated herein by reference.

Non-antibody binding molecules can be produced as dimers or multimers to increase avidity for the target antigen. For example, the antigen binding domain is expressed as a fusion with a constant region (Fc) of an antibody that forms Fc-Fc dimers. See, e.g., U.S. Pat. No. 7,115,396, the entire contents of which are incorporated herein by reference.

The therapeutic methods of the invention also may be practiced through the use of antibody fragments and antibody mimetics. As detailed below, a wide variety of antibody fragment and antibody mimetic technologies have now been developed and are widely known in the art. While a number of these technologies, such as domain antibodies, Nanobodies, and UniBodies make use of fragments of, or other modifications to, traditional antibody structures, there are also alternative technologies, such as Adnectins, Affibodies, DARPins, Anticalins, Avimers, and Versabodies that employ binding structures that, while they mimic traditional antibody binding, are generated from and function via distinct mechanisms. Some of these alternative structures are reviewed in Gill and Damle (2006) 17: 653-658.

Domain Antibodies (dAbs) are the smallest functional binding units of antibodies, corresponding to the variable regions of either the heavy (VH) or light (VL) chains of human antibodies. Domantis has developed a series of large and highly functional libraries of fully human VH and VL dAbs (more than ten billion different sequences in each library), and uses these libraries to select dAbs that are specific to therapeutic targets. In contrast to many conventional antibodies, domain antibodies are well expressed in bacterial, yeast, and mammalian cell systems. Further details of domain antibodies and methods of production thereof may be obtained by reference to U.S. Pat. Nos. 6,291,158; 6,582,915; 6,593,081; 6,172,197; 6,696,245; U.S. Serial No. 2004/0110941; European patent application No. 1433846 and European Patents 0368684 & 0616640; WO05/035572, WO04/101790, WO04/081026, WO04/058821, WO04/003019 and WO03/002609, the contents of each of which is herein incorporated by reference in its entirety.

Nanobodies are antibody-derived therapeutic proteins that contain the unique structural and functional properties of naturally-occurring heavy-chain antibodies. These heavy-chain antibodies contain a single variable domain (VHH) and two constant domains (CH2 and CH3). Importantly, the cloned and isolated VHH domain is a perfectly stable polypeptide harboring the full antigen-binding capacity of the original heavy-chain antibody. Nanobodies have a high homology with the VH domains of human antibodies and can be further humanized without any loss of activity.

Nanobodies are encoded by single genes and are efficiently produced in almost all prokaryotic and eukaryotic hosts, e.g., E. coli (see, e.g., U.S. Pat. No. 6,765,087, which is herein incorporated by reference in its entirety), molds (for example Aspergillus or Trichoderma) and yeast (for example Saccharomyces, Kluyveromyces, Hansenula or Pichia) (see, e.g., U.S. Pat. No. 6,838,254, which is herein incorporated by reference in its entirety). The production process is scalable and multi-kilogram quantities of Nanobodies have been produced. Because Nanobodies exhibit a superior stability compared with conventional antibodies, they can be formulated as a long shelf-life, ready-to-use solution.

The Nanoclone method (see, e.g., WO 06/079372, which is herein incorporated by reference in its entirety) is a proprietary method for generating Nanobodies against a desired target, based on automated high-throughout selection of B-cells and could be used in the context of the instant invention.

UniBodies are another antibody fragment technology, however this one is based upon the removal of the hinge region of IgG4 antibodies. The deletion of the hinge region results in a molecule that is essentially half the size of traditional IgG4 antibodies and has a univalent binding region rather than the bivalent binding region of IgG4 antibodies. It is also well known that IgG4 antibodies are inert and thus do not interact with the immune system, which may be advantageous for the treatment of diseases where an immune response is not desired, and this advantage is passed onto UniBodies. Further details of UniBodies may be obtained by reference to patent application WO2007/059782, which is herein incorporated by reference in its entirety.

Adnectin molecules are engineered binding proteins derived from one or more domains of the fibronectin protein. In one embodiment, adnectin molecules are derived from the fibronectin type 21 domain by altering the native protein which is composed of multiple beta strands distributed between two beta sheets. Depending on the originating tissue, fibronectin may contain multiple type 21 domains which may be denoted, e.g., 1Fn3, 2Fn3, 3Fn3, etc. Adnectin molecules may also be derived from polymers of 10Fn3 related molecules rather than a simple monomeric 10Fn3 structure.

Although the native 10Fn3 domain typically binds to integrin, 10Fn3 proteins adapted to become adnectin molecules are altered so to bind antigens of interest, e.g., a marker(s). In one embodiment, the alteration to the 10Fn3 molecule comprises at least one mutation to a beta strand. In a preferred embodiment, the loop regions which connect the beta strands of the 10Fn3 molecule are altered to bind to an antigen of interest, e.g., a marker(s).

The alterations in the 10Fn3 may be made by any method known in the art including, but not limited to, error prone PCR, site-directed mutagenesis, DNA shuffling, or other types of recombinational mutagenesis which have been referenced herein. In one example, variants of the DNA encoding the 10Fn3 sequence may be directly synthesized in vitro, and later transcribed and translated in vitro or in vivo. Alternatively, a natural 10Fn3 sequence may be isolated or cloned from the genome using standard methods (as performed, e.g., in U.S. Pat. Application No. 20070082365), and then mutated using mutagenesis methods known in the art.

An aptamer is another type of antibody-mimetic which may be used in the methods of the present invention. Aptamers are typically small nucleotide polymers that bind to specific molecular targets. Aptamers may be single or double stranded nucleic acid molecules (DNA or RNA), although DNA based aptamers are most commonly double stranded. There is no defined length for an aptamer nucleic acid; however, aptamer molecules are most commonly between 15 and 40 nucleotides long.

Aptamers may be generated using a variety of techniques, but were originally developed using in vitro selection (Ellington and Szostak. (1990) Nature. 346(6287):818-22) and the SELEX method (systematic evolution of ligands by exponential enrichment) (Schneider et al. 1992. J Mol Biol. 228(3):862-9) the contents of which are incorporated herein by reference. Other methods to make and uses of aptamers have been published including Klussmann. The Aptamer Handbook: Functional Oligonucleotides and Their Applications. ISBN: 978-3-527-31059-3; Ulrich et al. 2006. Comb Chem High Throughput Screen 9(8):619-32; Cerchia and de Franciscis. 2007. Methods Mol Biol. 361:187-200; Ireson and Kelland. 2006. Mol Cancer Ther. 2006 5(12):2957-62; U.S. Pat. Nos. 5,582,981; 5,840,867; 5,756,291; 6,261,783; 6,458,559; 5,792,613; 6,111,095; and U.S. patent application Ser. Nos. 11/482,671; 11/102,428; 11/291,610; and 10/627,543 which are all incorporated herein by reference.

Aptamer molecules made from peptides instead of nucleotides may also be used in the methods of the invention. Peptide aptamers share many properties with nucleotide aptamers (e.g., small size and ability to bind target molecules with high affinity) and they may be generated by selection methods that have similar principles to those used to generate nucleotide aptamers, for example Baines and Colas. 2006. Drug Discov Today. 11(7-8):334-41; and Bickle et al. 2006. Nat Protoc. 1(3):1066-91 which are incorporated herein by reference.

Affibody molecules represent a class of affinity proteins based on a 58-amino acid residue protein domain, derived from one of the IgG-binding domains of staphylococcal protein A. This three helix bundle domain has been used as a scaffold for the construction of combinatorial phagemid libraries, from which Affibody variants that target the desired molecules can be selected using phage display technology (Nord K, et al. Nat Biotechnol 1997; 15:772-7. Ronmark J, et al., Eur J Biochem 2002; 269:2647-55). Further details of Affibodies and methods of production thereof may be obtained by reference to U.S. Pat. No. 5,831,012 which is herein incorporated by reference in its entirety.

DARPins (Designed Ankyrin Repeat Proteins) are one example of an antibody mimetic DRP (Designed Repeat Protein) technology that has been developed to exploit the binding abilities of non-antibody polypeptides. Repeat proteins such as ankyrin or leucine-rich repeat proteins, are ubiquitous binding molecules, which occur, unlike antibodies, intra- and extracellularly. Their unique modular architecture features repeating structural units (repeats), which stack together to form elongated repeat domains displaying variable and modular target-binding surfaces. Based on this modularity, combinatorial libraries of polypeptides with highly diversified binding specificities can be generated. This strategy includes the consensus design of self-compatible repeats displaying variable surface residues and their random assembly into repeat domains.

Additional information regarding DARPins and other DRP technologies can be found in U.S. Patent Application Publication No. 2004/0132028 and International Patent Application Publication No. WO 02/20565, both of which are hereby incorporated by reference in their entirety.

Anticalins are an additional antibody mimetic technology, however in this case the binding specificity is derived from lipocalins, a family of low molecular weight proteins that are naturally and abundantly expressed in human tissues and body fluids. Lipocalins have evolved to perform a range of functions in vivo associated with the physiological transport and storage of chemically sensitive or insoluble compounds. Lipocalins have a robust intrinsic structure comprising a highly conserved ß-barrel which supports four loops at one terminus of the protein. These loops form the entrance to a binding pocket and conformational differences in this part of the molecule account for the variation in binding specificity between individual lipocalins.

Lipocalins are cloned and their loops are subjected to engineering in order to create Anticalins. Libraries of structurally diverse Anticalins have been generated and Anticalin display allows the selection and screening of binding function, followed by the expression and production of soluble protein for further analysis in prokaryotic or eukaryotic systems. Studies have successfully demonstrated that Anticalins can be developed that are specific for virtually any human target protein can be isolated and binding affinities in the nanomolar or higher range can be obtained.

Anticalins can also be formatted as dual targeting proteins, so-called Duocalins. A Duocalin binds two separate therapeutic targets in one easily produced monomeric protein using standard manufacturing processes while retaining target specificity and affinity regardless of the structural orientation of its two binding domains.

Additional information regarding Anticalins can be found in U.S. Pat. No. 7,250,297 and International Patent Application Publication No. WO 99/16873, both of which are hereby incorporated by reference in their entirety.

Another antibody mimetic technology useful in the context of the instant invention are Avimers. Avimers are evolved from a large family of human extracellular receptor domains by in vitro exon shuffling and phage display, generating multidomain proteins with binding and inhibitory properties. Linking multiple independent binding domains has been shown to create avidity and results in improved affinity and specificity compared with conventional single-epitope binding proteins. Other potential advantages include simple and efficient production of multitarget-specific molecules in Escherichia coli, improved thermostability and resistance to proteases. Avimers with sub-nanomolar affinities have been obtained against a variety of targets.

Additional information regarding Avimers can be found in U.S. Patent Application Publication Nos. 2006/0286603, 2006/0234299, 2006/0223114, 2006/0177831, 2006/0008844, 2005/0221384, 2005/0164301, 2005/0089932, 2005/0053973, 2005/0048512, 2004/0175756, all of which are hereby incorporated by reference in their entirety.

Versabodies are another antibody mimetic technology that could be used in the context of the instant invention. Versabodies are small proteins of 3-5 kDa with >15% cysteines, which form a high disulfide density scaffold, replacing the hydrophobic core that typical proteins have. The replacement of a large number of hydrophobic amino acids, comprising the hydrophobic core, with a small number of disulfides results in a protein that is smaller, more hydrophilic (less aggregation and non-specific binding), more resistant to proteases and heat, and has a lower density of T-cell epitopes, because the residues that contribute most to MHC presentation are hydrophobic. All four of these properties are well-known to affect immunogenicity, and together they are expected to cause a large decrease in immunogenicity.

Additional information regarding Versabodies can be found in U.S. Patent Application Publication No. 2007/0191272 which is hereby incorporated by reference in its entirety.

SMIPs™ (Small Modular ImmunoPharmaceuticals-Trubion Pharmaceuticals) engineered to maintain and optimize target binding, effector functions, in vivo half-life, and expression levels. SMIPS consist of three distinct modular domains. First they contain a binding domain which may consist of any protein which confers specificity (e.g., cell surface receptors, single chain antibodies, soluble proteins, etc). Secondly, they contain a hinge domain which serves as a flexible linker between the binding domain and the effector domain, and also helps control multimerization of the SMIP drug. Finally, SMIPS contain an effector domain which may be derived from a variety of molecules including Fc domains or other specially designed proteins. The modularity of the design, which allows the simple construction of SMIPs with a variety of different binding, hinge, and effector domains, provides for rapid and customizable drug design.

More information on SMIPs, including examples of how to design them, may be found in Zhao et al. (2007) Blood 110:2569-77 and the following U.S. Pat. App. Nos. 20050238646; 20050202534; 20050202028; 20050202023; 20050202012; 20050186216; 20050180970; and 20050175614.

In another aspect, the methods of the present invention employ immunoconjugate agents that target a marker(s) and which inhibit or down-modulate the marker(s). Agents that can be targeted to a marker(s) include, but are not limited to, cytotoxic agents, anti-inflammatory agents, e.g., a steroidal or nonsteroidal inflammatory agent, or a cytotoxin antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thioepa chlorambucil, melphalan, carmustine (BSNU) and lomustine (CCNU), cyclothosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine).

In another embodiment, marker(s) modulators employed in the methods of the invention are small molecules. As used herein, the term “small molecule” is a term of the art and includes molecules that are less than about 7500, less than about 5000, less than about 1000 molecular weight or less than about 500 molecular weight, and inhibit marker(s) activity. Exemplary small molecules include, but are not limited to, small organic molecules (e.g., Cane et al. 1998. Science 282:63), and natural product extract libraries. In another embodiment, the compounds are small, organic non-peptidic compounds. Like antibodies, these small molecule inhibitors indirectly or directly inhibit the activity of a marker(s).

In another embodiment, the marker(s) modulators employed in the methods of the present invention is an antisense nucleic acid molecule that is complementary to a gene encoding a marker(s) or to a portion of that gene, or a recombinant expression vector encoding the antisense nucleic acid molecule. As used herein, an “antisense” nucleic acid comprises a nucleotide sequence which is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule, complementary to an mRNA sequence or complementary to the coding strand of a gene. Accordingly, an antisense nucleic acid can form a hydrogen bond to a sense nucleic acid.

The use of antisense nucleic acids to down-modulate the expression of a particular protein in a cell is well known in the art (see e.g., Weintraub, H. et al., Antisense RNA as a molecular tool for genetic analysis, Reviews—Trends in Genetics, Vol. 1(1) 1986; Askari, F. K. and McDonnell, W. M. (1996) N. Eng. J. Med. 334:316-318; Bennett, M. R. and Schwartz, S. M. (1995) Circulation 92:1981-1993; Mercola, D. and Cohen, J. S. (1995) Cancer Gene Ther. 2:47-59; Rossi, J. J. (1995) Br. Med. Bull. 51:217-225; Wagner, R. W. (1994) Nature 372:333-335). An antisense nucleic acid molecule comprises a nucleotide sequence that is complementary to the coding strand of another nucleic acid molecule (e.g., an mRNA sequence) and accordingly is capable of hydrogen bonding to the coding strand of the other nucleic acid molecule. Antisense sequences complementary to a sequence of an mRNA can be complementary to a sequence found in the coding region of the mRNA, the 5′ or 3′ untranslated region of the mRNA or a region bridging the coding region and an untranslated region (e.g., at the junction of the 5′ untranslated region and the coding region). Furthermore, an antisense nucleic acid can be complementary in sequence to a regulatory region of the gene encoding the mRNA, for instance a transcription initiation sequence or regulatory element. Preferably, an antisense nucleic acid is designed so as to be complementary to a region preceding or spanning the initiation codon on the coding strand or in the 3′ untranslated region of an mRNA.

Antisense nucleic acids can be designed according to the rules of Watson and Crick base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of marker(s) mRNA, but more preferably is an oligonucleotide which is antisense to only a portion of the coding or noncoding region of marker(s) mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of marker(s) mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length.

An antisense nucleic acid can be constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides which can be used to generate the antisense nucleic acid include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xantine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylino sine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

The antisense nucleic acid molecules that can be utilized in the methods of the present invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a marker(s) to thereby inhibit expression by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule which binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecules to peptides or antibodies which bind to cell surface receptors or antigens. The antisense nucleic acid molecules can also be delivered to cells using vectors well known in the art and described in, for example, US20070111230 the entire contents of which are incorporated herein. To achieve sufficient intracellular concentrations of the antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred.

In yet another embodiment, the antisense nucleic acid molecule employed by the methods of the present invention can include an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al. (1987) Nucleic Acids. Res. 15:6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (Inoue et al. (1987) Nucleic Acids Res. 15:6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987) FEBS Lett. 215:327-330).

In another embodiment, an antisense nucleic acid used in the methods of the present invention is a compound that mediates RNAi. RNA interfering agents include, but are not limited to, nucleic acid molecules including RNA molecules which are homologous to a marker(s) or a fragment thereof, “short interfering RNA” (siRNA), “short hairpin” or “small hairpin RNA” (shRNA), and small molecules which interfere with or inhibit expression of a target gene by RNA interference (RNAi). RNA interference is a post-transcriptional, targeted gene-silencing technique that uses double-stranded RNA (dsRNA) to degrade messenger RNA (mRNA) containing the same sequence as the dsRNA (Sharp, P. A. and Zamore, P. D. 287, 2431-2432 (2000); Zamore, P. D., et al. Cell 101, 25-33 (2000). Tuschl, T. et al. Genes Dev. 13, 3191-3197 (1999)). The process occurs when an endogenous ribonuclease cleaves the longer dsRNA into shorter, 21- or 22-nucleotide-long RNAs, termed small interfering RNAs or siRNAs. The smaller RNA segments then mediate the degradation of the target mRNA. Kits for synthesis of RNAi are commercially available from, e.g., New England Biolabs and Ambion. In one embodiment one or more of the chemistries described above for use in antisense RNA can be employed.

In still another embodiment, an antisense nucleic acid is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity which are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach, 1988, Nature 334:585-591) can be used to catalytically cleave marker(s) mRNA transcripts to thereby inhibit translation of the marker(s) mRNA.

Alternatively, gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of a marker(s) (e.g., the promoter and/or enhancers) to form triple helical structures that prevent transcription of the marker(s) gene. See generally, Helene, C., 1991, Anticancer Drug Des. 6(6):569-84; Helene, C. et al., 1992, Ann. N.Y. Acad. Sci. 660:27-36; and Maher, L. J., 1992, Bioassays 14(12):807-15.

In another embodiment, the marker(s) modulator used in the methods of the present invention is a fusion protein or peptidic compound derived from the marker(s) amino acid sequence. In particular, the inhibitory compound comprises a fusion protein or a portion of a marker(s) (or a mimetic thereof) that mediates interaction of the marker(s) with a target molecule such that contact of the marker(s) with this fusion protein or peptidic compound competitively inhibits the interaction of the marker(s) with the target molecule. Such fusion proteins and peptidic compounds can be made using standard techniques known in the art. For example, peptidic compounds can be made by chemical synthesis using standard peptide synthesis techniques and then introduced into cells by a variety of means known in the art for introducing peptides into cells (e.g., liposome and the like).

The in vivo half-life of the fusion protein or peptidic compounds of the invention can be improved by making peptide modifications, such as the addition of N-linked glycosylation sites into the marker(s) or conjugating the marker(s) to poly(ethylene glycol) (PEG; pegylation), e.g., via lysine-monopegylation. Such techniques have proven to be beneficial in prolonging the half-life of therapeutic protein drugs. It is expected that pegylation of marker(s) polypeptides of the invention may result in similar pharmaceutical advantages.

In addition, pegylation can be achieved in any part of a polypeptide of the invention by the introduction of a nonnatural amino acid. Certain nonnatural amino acids can be introduced by the technology described in Deiters et al., J Am Chem Soc 125:11782-11783, 2003; Wang and Schultz, Science 301:964-967, 2003; Wang et al., Science 292:498-500, 2001; Zhang et al., Science 303:371-373, 2004 or in U.S. Pat. No. 7,083,970. Briefly, some of these expression systems involve site-directed mutagenesis to introduce a nonsense codon, such as an amber TAG, into the open reading frame encoding a polypeptide of the invention. Such expression vectors are then introduced into a host that can utilize a tRNA specific for the introduced nonsense codon and charged with the nonnatural amino acid of choice. Particular nonnatural amino acids that are beneficial for purpose of conjugating moieties to the polypeptides of the invention include those with acetylene and azido side chains. Marker(s) polypeptides containing these novel amino acids can then be pegylated at these chosen sites in the protein.

2. Stimulatory Agents

According to a modulatory method of the invention, the expression and/or activity of a marker(s) is stimulated in a cell or subject by contacting the cell with (or administering to a subject) a stimulatory agent. Stimulatory agents of the invention can be, for example, molecules that act to stimulate or increase the expression and/or activity of the marker(s).

Examples of such stimulatory agents include active marker(s) polypeptide and nucleic acid molecules encoding the marker(s) that are introduced into the cell to increase expression and/or activity of the marker in the cell. A preferred stimulatory agent is a nucleic acid molecule encoding a marker(s) polypeptide, wherein the nucleic acid molecule is introduced into the cell in a form suitable for expression of the active marker(s) polypeptide in the cell. To express a marker(s) polypeptide in a cell, typically a marker(s)-encoding cDNA (full length or partial cDNA sequence) is first introduced into a recombinant expression vector using standard molecular biology techniques, and the vector may be transfected into cells using standard molecular biology techniques. A cDNA can be obtained, for example, by amplification using the polymerase chain reaction (PCR), using primers based on the marker(s) nucleotide sequence or by screening an appropriate cDNA library.

The nucleic acids for use in the methods of the invention can also be prepared, e.g., by standard recombinant DNA techniques. A nucleic acid of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which has been automated in commercially available DNA synthesizers (See e.g., Itakura et al. U.S. Pat. No. 4,598,049; Caruthers et al. U.S. Pat. No. 4,458,066; and Itakura U.S. Pat. Nos. 4,401,796 and 4,373,071, incorporated by reference herein).

In one embodiment, a nucleic acid molecule encoding a marker(s) may be present in an inducible construct. In another embodiment, a nucleic acid molecule encoding marker(s) may be present in a construct which leads to constitutive expression. In one embodiment, a nucleic acid molecule encoding marker(s) may be delivered to cells, or to subjects, in the absence of a vector.

A nucleic acid molecule encoding marker(s) may be delivered to cells or to subjects using a viral vector, preferably one whose use for gene therapy is well known in the art. Techniques for the formation of vectors or virions are generally described in “Working Toward Human Gene Therapy,” Chapter 28 in Recombinant DNA, 2nd Ed., Watson, J. D. et al., eds., New York: Scientific American Books, pp. 567-581 (1992). An overview of suitable viral vectors or virions is provided in Wilson, J. M., Clin. Exp. Immunol. 107(Suppl. 1):31-32 (1997), as well as Nakanishi, M., Crit. Rev. Therapeu. Drug Carrier Systems 12:263-310 (1995); Robbins, P. D., et al., Trends Biotechnol. 16:35-40 (1998); Zhang, J., et al., Cancer Metastasis Rev. 15:385-401(1996); and Kramm, C. M., et al., Brain Pathology 5:345-381 (1995). Such vectors may be derived from viruses that contain RNA (Vile, R. G., et al., Br. Med Bull. 51:12-30 (1995)) or DNA (Ali M., et al., Gene Ther. 1:367-384 (1994)).

Examples of viral vector systems utilized in the gene therapy art and, thus, suitable for use in the present invention, include the following: retroviruses (Vile, R. G., supra; U.S. Pat. Nos. 5,741,486 and 5,763,242); adenoviruses (Brody, S. L., et al., Ann. N.Y. Acad. Sci. 716: 90-101 (1994); Heise, C. et al., Nat. Med. 3:639-645 (1997)); adenoviral/retroviral chimeras (Bilbao, G., et al., FASEB J. 11:624-634 (1997); Feng, M., et al., Nat. Biotechnol. 15:866-870 (1997)); adeno-associated viruses (Flotte, T. R. and Carter, B. J., Gene Ther. 2:357-362 (1995); U.S. Pat. No. 5,756,283); herpes simplex virus I or II (Latchman, D. S., Mol. Biotechnol. 2:179-195 (1994); U.S. Pat. No. 5,763,217; Chase, M., et al., Nature Biotechnol. 16:444-448 (1998)); parvovirus (Shaughnessy, E., et al., Semin Oncol. 23:159-171 (1996)); reticuloendotheliosis virus (Donburg, R., Gene Therap. 2:301-310 (1995)). Extrachromosomal replicating vectors may also be used in the gene therapy methods of the present invention. Such vectors are described in, for example, Calos, M. P. (1996) Trends Genet. 12:463-466, the entire contents of which are incorporated herein by reference. Other viruses that can be used as vectors for gene delivery include poliovirus, papillomavirus, vaccinia virus, lentivirus, as well as hybrid or chimeric vectors incorporating favorable aspects of two or more viruses (Nakanishi, M. (1995) Crit. Rev. Therapeu. Drug Carrier Systems 12:263-310; Zhang, J., et al. (1996) Cancer Metastasis Rev. 15:385-401; Jacoby, D. R., et al. (1997) Gene Therapy 4:1281-1283).

The term “AAV vector” refers to a vector derived from an adeno-associated virus serotype, including without limitation, AAV-1, AAV-2, AAV-3, AAV-4, AAV-5, or AAVX7. “rAAV vector” refers to a vector that includes AAV nucleotide sequences as well as heterologous nucleotide sequences. rAAV vectors require only the 145 base terminal repeats in cis to generate virus. All other viral sequences are dispensable and may be supplied in trans (Muzyczka (1992) Curr. Topics Microbiol. Immunol. 158:97). Typically, the rAAV vector genome will only retain the inverted terminal repeat (ITR) sequences so as to maximize the size of the transgene that can be efficiently packaged by the vector. The ITRs need not be the wild-type nucleotide sequences, and may be altered, e.g., by the insertion, deletion or substitution of nucleotides, as long as the sequences provide for functional rescue, replication and packaging. In particular embodiments, the AAV vector is an AAV2/5 or AAV2/8 vector. Suitable AAV vectors are described in, for example, U.S. Pat. No. 7,056,502 and Yan et al. (2002) J. Virology 76(5):2043-2053, the entire contents of which are incorporated herein by reference.

As used herein, the term “lentivirus” refers to a group (or genus) of retroviruses that give rise to slowly developing disease. Viruses included within this group include HIV (human immunodeficiency virus; including but not limited to HIV type 1 and HIV type 2), the etiologic agent of the human acquired immunodeficiency syndrome (AIDS); visna-maedi, which causes encephalitis (visna) or pneumonia (maedi) in sheep; the caprine arthritis-encephalitis virus, which causes immune deficiency, arthritis, and encephalopathy in goats; equine infectious anemia virus (EIAV), which causes autoimmune hemolytic anemia, and encephalopathy in horses; feline immunodeficiency virus (FIV), which causes immune deficiency in cats; bovine immune deficiency virus (BIV), which causes lymphadenopathy, lymphocytosis, and possibly central nervous system infection in cattle; and simian immunodeficiency virus (SIV), which cause immune deficiency and encephalopathy in sub-human primates. Diseases caused by these viruses are characterized by a long incubation period and protracted course. Usually, the viruses latently infect monocytes and macrophages, from which they spread to other cells. HIV, FIV, and SIV also readily infect T lymphocytes (i.e., T-cells). In one embodiment of the invention, the lentivirus is not HIV.

As used herein, the term “adenovirus” (“Ad”) refers to a group of double-stranded DNA viruses with a linear genome of about 36 kb. See, e.g., Berkner et al., Curr. Top. Microbiol. Immunol., 158: 39-61 (1992). In some embodiments, the adenovirus-based vector is an Ad-2 or Ad-5 based vector. See, e.g., Muzyczka, Curr. Top. Microbiol. Immunol., 158: 97-123, 1992; Ali et al., 1994 Gene Therapy 1: 367-384; U.S. Pat. Nos. 4,797,368, and 5,399,346. Suitable adenovirus vectors derived from the adenovirus strain Ad type 5 dl324 or other strains of adenovirus (e.g., Ad2, Ad3, Ad7 etc.) are well known to those skilled in the art. Recombinant adenoviruses are advantageous in that they do not require dividing cells to be effective gene delivery vehicles and can be used to infect a wide variety of cell types. Additionally, introduced adenovirus DNA (and foreign DNA contained therein) is not integrated into the genome of a host cell but remains episomal, thereby avoiding potential problems that can occur as a result of insertional mutagenesis in situations where introduced DNA becomes integrated into the host genome (e.g., retroviral DNA). Moreover, the carrying capacity of the adenovirus genome for foreign DNA is large (up to 8 kilobases) relative to other gene delivery vectors (Haj-Ahmand et al. J. Virol. 57, 267-273 [1986]).

In one embodiment, an adenovirus is a replication defective adenovirus. Most replication-defective adenoviral vectors currently in use have all or parts of the viral E1 and E3 genes deleted but retain as much as 80% of the adenovirus genetic material. Adenovirus vectors deleted for all viral coding regions are also described by Kochanek et al. and Chamberlain et al. (U.S. Pat. No. 5,985,846 and U.S. Pat. No. 6,083,750). Such viruses are unable to replicate as viruses in the absence of viral products provided by a second virus, referred to as a “helper” virus.

In one embodiment, an adenoviral vector is a “gutless” vector. Such vectors contain a minimal amount of adenovirus DNA and are incapable of expressing any adenovirus antigens (hence the term “gutless”). The gutless replication defective Ad vectors provide the significant advantage of accommodating large inserts of foreign DNA while completely eliminating the problem of expressing adenoviral genes that result in an immunological response to viral proteins when a gutless replication defective Ad vector is used in gene therapy. Methods for producing gutless replication defective Ad vectors have been described, for example, in U.S. Pat. No. 5,981,225 to Kochanek et al., and U.S. Pat. Nos. 6,063,622 and 6,451,596 to Chamberlain et al; Parks et al., PNAS 93:13565 (1996) and Lieber et al., J. Virol. 70:8944-8960 (1996).

In another embodiment, an adenoviral vector is a “conditionally replicative adenovirus” (“CRAds”). CRAds are genetically modified to preferentially replicate in specific cells by either (i) replacing viral promoters with tissue specific promoters or (ii) deletion of viral genes important for replication that are compensated for by the target cells only. The skilled artisan would be able to identify epithelial cell specific promoters.

Other art known adenoviral vectors may be used in the methods of the invention. Examples include Ad vectors with recombinant fiber proteins for modified tropism (as described in, e.g., van Beusechem et al., 2000 Gene Ther. 7: 1940-1946), protease pre-treated viral vectors (as described in, e.g., Kuriyama et al., 2000 Hum. Gene Ther. 11: 2219-2230), E2a temperature sensitive mutant Ad vectors (as described in, e.g., Engelhardt et al., 1994 Hum. Gene Ther. 5: 1217-1229), and “gutless” Ad vectors (as described in, e.g., Armentano et al., 1997 J. Virol. 71: 2408-2416; Chen et al., 1997 Proc. Nat. Acad. Sci. USA 94: 1645-1650; Schieder et al., 1998 Nature Genetics 18: 180-183).

The vector will include one or more promoters or enhancers, the selection of which will be known to those skilled in the art. Suitable promoters include, but are not limited to, the retroviral long terminal repeat (LTR), the SV40 promoter, the human cytomegalovirus (CMV) promoter, and other viral and eukaryotic cellular promoters known to the skilled artisan.

Guidance in the construction of gene therapy vectors and the introduction thereof into affected subjects for therapeutic purposes may be obtained in the above-referenced publications, as well as in U.S. Pat. Nos. 5,631,236, 5,688,773, 5,691,177, 5,670,488, 5,529,774, 5,601,818, and PCT Publication No. WO 95/06486, the entire contents of which are incorporated herein by reference.

Generally, methods are known in the art for viral infection of the cells of interest. Gene therapy vectors comprising a nucleic acid molecule encoding a marker(s) can be delivered to a subject or a cell by any suitable method in the art, for example, intravenous injection, local administration, e.g., application of the nucleic acid in a gel, oil, or cream, (see, e.g., U.S. Pat. No. 5,328,470), stereotactic injection (see, e.g., Chen et al. (1994) Proc. Natl. Acad. Sci. U.S.A. 91:3054), gene gun, or by electroporation (see, e.g., Matsuda and Cepko (2007) Proc. Natl. Acad. Sci. U.S.A. 104:1027), using lipid-based transfection reagents, or by any other suitable transfection method.

As used herein, the terms “transformation” and “transfection” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection (e.g., using commercially available reagents such as, for example, LIPOFECTIN® (Invitrogen Corp., San Diego, Calif.), LIPOFECTAMINE® (Invitrogen), FUGENE® (Roche Applied Science, Basel, Switzerland), JETPEI™ (Polyplus-transfection Inc., New York, N.Y.), EFFECTENE® (Qiagen, Valencia, Calif.), DREAMFECT™ (OZ Biosciences, France) and the like), or electroporation (e.g., in vivo electroporation). Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.

In one embodiment, a marker(s) is delivered to a subject or cells in the form of a peptide or protein. In order to produce such peptides or proteins, recombinant expression vectors of the invention can be designed for expression of one or more marker(s) proteins, and/or portion(s) thereof in prokaryotic or eukaryotic cells. For example, one or more marker proteins and/or portion(s) thereof can be expressed in bacterial cells such as E. coli, insect cells (using baculovirus expression vectors) yeast cells or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

In one embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include retinal cell-type-specific promoters (e.g., rhodopsin regulatory sequences, Cabp5, Cralbp, Nrl, Crx, Ndrg4, clusterin, Rax, Hes1 and the like (Matsuda and Cepko, supra)), the albumin promoter (liver-specific, Pinkert et al. (1987) Genes Dev. 1:268), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle (1989) Proc. Natl. Acad. Sci. U.S.A. 86:5473). Developmentally-regulated promoters are also encompassed, for example the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev. 3:537).

Application of the methods of the invention for the treatment and/or prevention of a active TB can result in curing the disorder, decreasing at least one symptom associated with the disorder, either in the long term or short term or simply a transient beneficial effect to the subject. Accordingly, as used herein, the terms “treat,” “treatment” and “treating” include the application or administration of agents, as described herein, to a subject who is suffering from a active TB, or who is susceptible to such conditions with the purpose of curing, healing, alleviating, relieving, altering, remedying, ameliorating, improving or affecting such conditions or at least one symptom of such conditions. As used herein, the condition is also “treated” if recurrence of the condition is reduced, slowed, delayed or prevented.

A modulatory agent, such as a chemical compound, can be administered to a subject as a pharmaceutical composition. Such compositions typically comprise the modulatory agent and a pharmaceutically acceptable carrier, discussed supra. As used herein the term “pharmaceutically acceptable carrier” is intended to include any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in the compositions is contemplated. Supplementary active compounds can also be incorporated into the compositions. Pharmaceutical compositions can be prepared as described above.

E. Methods of Identifying Active TB Biomarkers

The present invention further provides methods for identifying active biomarkers useful as markers for, e.g., disease (prognostics and diagnostics), therapeutic effectiveness of a drug (theranostics) and of drug toxicity. For example, as described above, the markers described herein and the markers identified using the methods for biomarker discovery are useful for, e.g., determining whether a subject has active TB; monitoring the effectiveness of a therapy for treating TB, reducing or slowing down the progression of TB, and/or reducing or inhibiting the development of complications associated with the disease in a subject; in screening assays to identify molecules which modulate, e.g., decrease or increase, the expression and/or activity of a marker(s) of the invention for e.g., use as therapeutics.

Methods for identifying an active TB marker are described in the working examples and include identifying proteins differentially expressed in the serum of HIV+ subjects having TB, identifying proteins differentially expressed in the serum of HIV− subjects having TB thereby generating a provisional list of active TB markers, determining the level of a marker in a sample form a control subject, e.g., an HIV+ subject having latent TB, an HIV− subject having latent TB, an HIV+ subject having ORD, and an HIV− subject having ORD, and determining the level of the marker in a test sample from a subject, e.g., an HIV+ subject having active TB and an HIV− subject having active TB. A difference in the level of a marker in the control sample as compared to the level in the test sample, e.g., a statistically significant level, identifies the marker as an active TB marker.

IV. Kits of the Invention

The invention also provides kits for determining whether a subject has active TB. Kits for monitoring the effectiveness of a treatment for active TB are also provided.

These kits include means for determining the level of one or more markers of the invention and instructions for use of the kit.

The kits of the invention may optionally comprise additional components useful for performing the methods of the invention. By way of example, the kits may comprise reagents for obtaining a biological sample from a subject, a control sample, one or more sample compartments, a diabetic therapeutic, an instructional material which describes performance of a method of the invention and tissue specific controls/standards.

The reagents for determining the level of one or more marker(s) can include, for example, buffers or other reagents for use in an assay for evaluating the level of one or more markers, e.g., expression level (e.g., at either the mRNA or protein level). The instructions can be, for example, printed instructions for performing the assay for evaluating the level of one or more marker(s) of the invention.

The reagents for isolating a biological sample from a subject can comprise one or more reagents that can be used to obtain a fluid or tissue from a subject, such as means for obtaining a saliva or blood.

The kits of the invention may further comprise reagents for culturing a sample obtained from a subject.

Preferably, the kits are designed for use with a human subject.

The present invention is further illustrated by the following examples which should not be construed as further limiting. The contents of all references, patents and published patent applications cited throughout this application, as well as the Figures, are expressly incorporated herein by reference in their entirety.

Examples Example I. Biomarker Identification Materials and Methods Study Design and Subjects

The studies described below entailed two parts, a discovery and a verification phase. For both parts, independent serum samples from HIV uninfected (HIV−) and HIV-infected (HIV+) subjects were evaluated. Within both the HIV− and the HIV+ subjects, TB cases were compared to various controls groups in a case-control design. Subjects were 21-80 years old and enrolled at 4 public hospitals in New York City from 2007-2011. TB cases were confirmed by a positive respiratory or other body fluid culture for M. tuberculosis or, if culture-negative, by a positive response to antituberculous treatment (ATT). They were further categorized by sputum smear microscopy results and considered smear-positive if one of the initial three sputum smears were positive regardless of number of acid-fast bacilli (AFB) detected. All TB patients were enrolled prior to or within the first 7 days of ATT. Control groups consisted of either asymptomatic healthy volunteers without abnormalities on chest X-ray who were categorized by Tuberculin skin-test (TST) or of symptomatic patients with signs and symptoms of TB who were ultimately diagnosed with an other respiratory disease (ORD). TST negative controls were considered TB uninfected. All TST+ controls had a history of M. bovis Bacillus Calmette-Guerin (BCG) vaccine and were further categorized by an interferon-gamma release assay result (IGRA; QuantiFERON®-TB Gold, Celestis, Australia). Asymptomatic controls with a positive IGRA were considered to have latent tuberulosis infection (LTBI). All subjects provided written informed consent prior to enrollment. Approval for human subjects' research was obtained from the Internal Review Boards at the New York University School of Medicine, NY, NY, and the Albert Einstein College of Medicine, Bronx, N.Y. For the discovery phase sera from TB patients (n=24) and asymptomatic controls (n=40), and for the verification phase sera from a different set of TB patients (n=46), ORD patients (n=6) and asymptomatic controls (n=97) were evaluated and compared. Subjects were bled at the time of enrolment, and sera were stored at −80° C. until tested. Written informed consent was obtained from all subjects prior to enrollment. Approval for human subjects' research was obtained from the Institutional Review Board of the Albert Einstein College of Medicine.

Sample Processing.

To avoid introducing bias in the sample preparation, the samples were grouped into blocks containing one of each of the groups (if possible). The order of the groups within each block was then randomized. For the discovery samples, all samples were depleted of abundant proteins with an antibody column (IgY14 and Supermix, Sigma). After the depletion step for all samples, the remaining lower abundance proteins were digested with trypsin (Promega). Following freeze-drying of the digested samples, they were resolubilized and treated with TCEP (tris(2-carboxyethyl)phosphine) to reduce disulfide bonds. The samples were then desalted by solid phase extraction using a 3M Empore C18 desalting plate and distributed into 96-well plates and vacuum evaporated. Peptides were stored at −20° C. until use. For the verification samples, most abundant proteins were depleted from all samples by tandem immunodepletion using an HSA/IgG column (Agilent Technologies) due to the unusually high levels of immunoglobulins in the blood of the HIV+ patients and with an IgY14 and Supermix (Sigma) column. After the depletion step for all samples, the remaining lower abundance proteins were digested with trypsin overnight (Promega) at a trypsin to protein ratio of 1:10, and desalted by solid phase extraction using a 3M Empore C18 desalting plate. Peptides were freeze-dried and stored at −20° C. until use.

Tandem Mass Spectrometry Analysis

Freeze dried peptides were resuspended in 92.5/7.5 water/acn+0.2% formic acid and analyzed using a nanoAcquity pump (Waters) coupled to a Q-TOF mass spectrometer (Waters). Peptide separation was achieved using a Waters nanoAcquity Symmetry UPLC Trap column (180 μm×20 mm, 5 μm particle size) and a Waters nanoAcquity UPLC BEH300 analytical column (150 μm×100 mm, 1.7 μm particle size). Each sample was loaded on the trapping column for 3 min at a flow rate of 10 μL/min, and then the gradient was started at a flow rate at 1.8 μL/min. The total run time per sample was 105 min. Components were detected and matched across all samples using the Elucidator software (Rosetta Biosoftware) and compared for relative peak intensity. All intensity values were log (base e) transformed with values <0 replaced by 0. Peak intensity was normalized to account for small differences in protein concentration between samples: a subset of the samples was used to create an average sample (i.e. the Reference sample) against which all samples were then normalized. The normalization factors were chosen so that the median of log ratios between each sample and the Reference sample over all the peptides was adjusted to zero. For batch-effect correction, a one-way ANOVA model Iij=M+Dij+εij (I: intensity, M: overall interception, and D: batch-factor) was solved and parameters Di (i=1,2) under the constraint of Σi=12 (Ni*Di)=0 were obtained; the Di's were then subtracted from the normalized intensities to form the “batch-effect corrected” intensities. Intensities below the limit of detection (LOD=30) were transformed to avoid spurious large fold changes: intensities in the range of (0, LOD) were linearly mapped to the range of (LOD/2, LOD). A one-way ANOVA analysis was then applied to identify peptides that were differentially expressed between the groups of interest. High stringency thresholds were used to ensure the statistical significance of the identified peptides. Each group was analyzed using the same one-way ANOVA model [=(Montgomery, D. C., Design and Analysis of Experiments, Wiley, 2001; Keeping, E. S., Introduction to Statistical Inference, Dover Publication, Inc. 1995): Iij=M+Ci+εij where I is the peptide intensity, M is the overall average intensity, C is the ‘clinical group’ factor, and ε is random error. FDR (false detection rate) and q-value were calculated, based on the p-values obtained from the ANOVA, using Storey's method (Storey, J. D. (2002) Journal of the Royal Statistical Society 64(3):479-498) to make multiple testing adjustments (implemented in MATLAB) (mathworks.com/access/helpdesk/help/helpdesk.html; MATLAB for Math Works Inc.). ‘Post hoc’ contrast analyses were conducted using Tukey's hsd (Hochberg, Y., and A. C. Tamhane. Multiple Comparison Procedures. John Wiley & Sons, 1987) method to calculate p-values associated with each pair wise comparison. Protein identification was done by analysis of replicate samples by tandem mass spectrometry (LC-MS/MS). Differentially expressed peptides were targeted for sequencing, and the resulting fragmentation patterns were matched to the corresponding peptide sequences found in a custom protein database using Mascot (Matrix Science) software. A protein level analysis was then applied using an extension of the one-way ANOVA used above in the peptide level analysis, which takes into consideration that one protein may have several peptides, by introducing a ‘peptide factor’ in the model: Iijk=M+Ci+Pj+εijk, where I is the protein intensity, M an overall constant, C the ‘clinical group’, and P the peptide factor. The number of the levels for P is protein-dependent, equal to the number of children peptides for the protein. These calculations were implemented in MATLAB (mathworks.com/access/helpdesk/help/helpdesk.html; MATLAB for Math Works Inc.). Proteins were considered to be differentially expressed if they met the following thresholds: p- and q-values<0.05, and Differential Intensity (DI) superior at 1.1-fold change.

Multiple Reaction Monitoring Mass Spectrometry

A multiplex MRM assay was developed for the selected biomarker candidates. The assay contained 244 peptides representing 89 host proteins and 2 M. tuberculosis proteins. Peptides were synthesized by JPT Peptide Technologies (Berlin, Germany). The synthesized peptides were resolubilized in 72/25 water/DMSO, pooled and diluted with water+0.2% formic acid to a final concentration of 2 nmol/mL. Five μL of this solution was analyzed on a QTRAP 5500 mass spectrometer (ABSciex, Canada) using a 320 μm×150 mm, 5 μm particle size, Thermo Biobasic C18 column. A linear gradient of 10-40% acetonitrile (0.2% formic acid) in 30 minutes was used for peptide separation. MS/MS spectra of the synthetic peptides were acquired using selected reaction monitoring (SRM)-triggered MS/MS allowing the identification of peptide and peptide fragments (transitions). The two most intense fragment ions (b or y fragment ions only) in the MS/MS spectrum and its elution time were determined for each acquired peptide. The collision energy (CE) was then optimized for each of the chosen transitions. The CE values evaluated were the empirical calculated CE value and the empirical CE value −6, +3 and +6. Independent plasma samples from those used for the discovery study by tandem mass spectrometry were processed as described and the resulting peptides were analyzed by the MRM assay.

Expression analysis of MRM data was performed using R version 2.14.0, platform x86_64-pc-mingw32/x64 (64-bit). The calculation of q-values was done using function “qvalue” from Storey's package “qvalue” version 1.24.0. A limit of quantification (LOQ), defined as an intensity value below which the measure is deemed unreliable, was determined empirically according to the QTRAP 5500 and was set to 10000, pre-normalization. The detection rate (DR), defined for each group that needed to be compared, was defined as the proportion of samples with a raw intensity (i.e. pre normalization) value greater or equal to the LOQ. Transitions for which the DR was below 50% for one of the two groups were excluded from expression analysis. Prior to expression analysis, an outlier and pattern detection analysis was performed. The distribution of sample detection was investigated and a sample was rejected from analysis because of a poor detection rate. The sample intensity average distribution by depletion day was also investigated and three samples were rejected for being too weak. A standard Principal Component Analysis (PCA) was applied to the In intensities in order to visually assess any pattern in the data that are likely to be unrelated to sample condition. Differential intensity ratios (DI) were then calculated for each transition, for two-group comparisons (e.g. Active TB vs Latent TB), as the ratio of the median normalized intensities of each group. Prior to calculating the differential intensity ratios, all intensity values that were below the LOQ quantity in the raw data prior to normalization were replaced by the half-LOQ value. Student's t-test were applied for the expression analysis Protein-level statistics were also computed by first linearly combining the transitions of a given protein into a single variable and then applying a t-test on it.

IPA Analysis

Data were analyzed through the use of IPA (Ingenuity® Systems, ingenuity.com). Expression analysis results were combined by cell type. Differential expression results (DI cut-off of 1.1 and p<0.05 and q<0.05) were analyzed independently for HIV− and HIV+ backgrounds. The Functional Analysis identified the biological functions and/or diseases that were most significant to each dataset. Proteins from the dataset that were associated with biological functions and/or diseases in the Ingenuity Knowledge Base were considered for the analysis. Right-tailed Fisher's exact test was used to calculate a p-value determining the probability that each biological function and/or disease assigned to that data set is due to chance alone. Each protein was assigned to a functional category mainly based on IPA analysis, combined with additional literature search.

Panel Definition

Area Under the Curve (AUC) values were computed from bootstrap. Select n samples with replacement (i.e. take a sample at random, then a second—with the first selected sample being possibly selected again, and so on). By design, some samples are left out, called out-of-bag. The selected samples (some more than once) are called the bootstrap samples. Build panel on the bootstrap samples and evaluate on the out-of-bag sample by calculating AUC. This was done 100 times. Reported AUC is the average of the 100 AUC. Each protein was represented by a single transition. Transitions with a DR lower than 80% were filtered-out. Among the remaining transitions, proteins for which the transitions were not trending the same way, based on DI, were filtered-out. The selected transition of a protein was the one with the highest DR. In situation of ties, this transition was selected randomly. Logistic Regression models were built with the proteins (i.e. represented by its selected transition) as explanatory variables. All combinations of proteins from 1 to 4 were systematically fitted into such logistic models. Proteins were then ranked by their propensity to be a good team player. For k from 1 to 4, combinations were ranked by their AUC and for each protein, the mean rank of the combinations they appear in, for a given k, was calculated. Within each k, the protein rank was calculated as the rank of the average rank. The final rank was taken as the weighted average over k of the ranks.

Results

Identification of Plasma Protein Changes Associated with Active Pulmonary TB

One hundred forty plasma proteins were identified to be significantly differentially expressed in the serum of HIV− subjects with active TB in comparison to controls (uninfected and LTBI) ((p<0.05); FIG. 1, Tables 2A-2E). Tables 2A-2E provide the DI (Differential Intensity) value for each protein. If the DI value is above 1 the level of the protein is upregulated. If the DI value is less than 1, the level of the marker is downregulated. The differentially expressed proteins segregated into a small number of biological processes. The 3 most populated groups were associated with the immune response, lipid transport and regulation, and tissue development and repair (FIG. 1).

One hundred and twenty six plasma proteins were identified to be significantly (p<0.05) differentially expressed in serum from HIV+ subjects with active TB in comparison to HIV+ controls (uninfected and LTBI) (FIG. 2, Tables 2A-2E). The differentially expressed proteins segregated into the same main biological function categories defined by the HIV− groups.

These results indicate that the host physiological changes associated with TB can be sufficiently reflected in the blood and that a relatively detailed assessment of the host response to TB can be made. Furthermore, effects of HIV co-infection also appear to be sufficiently reflected in the blood. This demonstrates that host biomarkers for TB can be identified in body fluids, such as blood, independent from the site of M. tuberculosis infection.

Candidate Serum Protein Biomarkers of Active TB

All the significantly differentially expressed proteins in the HIV− or HIV+ subjects were individually evaluated for inclusion into a multiplex MRM-MS assay which would be used to assay an independent set of clinical samples. The differentially expressed proteins were ranked by whether they had a known or novel association with infectious disease, whether they belonged to the acute phase response, and how frequently they were observed to be differentially expressed in the Caprion plasma study database which contained studies from a wide range of disease indications. This ranking was done to assess the likelihood of the significantly differentially proteins as potentially specific host response biomarkers of active TB. Proteins that were components of the acute phase response or had been repeatedly observed to be differentially expressed in multiple studies were assessed most likely to be non-specific and were not selected for inclusion in the multiplex MRM-MS assay.

Eighty nine of the differentially proteins were selected for inclusion in the multiplex assay (Table 1) as well as two M. tuberculosis proteins and 17 other host proteins. The M. tuberculosis proteins included were not detected in the verification samples. This result was not surprising, given the comparatively early stage of TB all the subjects used in the study. The differential expression measured for each of the host biomarker candidates identified in the discovery sample set, however, was comparable to their corresponding expression in the verification sample set. The directionality of the expression change of each candidate biomarker was reproduced in both sample sets, though the magnitude of the changes observed were greater in the verification set, owing to the better resolution of the QTRAP mass spectrometer used for the MRM-MS data acquisition compared to the QTOF instrument used in the initial biomarker discovery experiments. These results demonstrated that the differential expression observed in the initial sample groups could be reproduced using an independent set of samples, and that the effects on the host physiology observed were reproducible.

The biomarker verification sample set contained an additional group than the discovery sample set, one comprised of samples from subjects with diverse other respiratory disease than TB (ORD), such as pneumonias. These subjects displayed a similar clinical presentation as active TB, and represented the diseases that a TB diagnostic test would need to distinguish from. Thus, these samples were used to assess the clinically relevant specificity of the candidate biomarkers in the multiplex MRM-MS assay. The HIV+ and HIV− groups were analyzed separately. Classification analysis demonstrated that individually, the vast majority of the biomarker candidates were not able to accurately distinguish between TB and ORDs, independent of HIV status. The performance of the individual biomarker candidates ranged between 0.636 to 0.746 AUC for the HIV− groups, and 0.561 to 0.804 AUC for the HIV+ groups. The only exception was CD14, which was able to distinguish between TB and the other pneumonias with an AUC of 0.950, but only in the HIV− groups. Its performance in the HIV+ groups was a much less effective 0.612.

Combining the biomarker candidates into panels was a more effective strategy to derive high performing discriminators (Tables 3 and 4). Even so, most of the candidate biomarkers did not appear to have utility in panel combinations. Only 13 of the 89 (15%) candidate biomarker proteins assayed were able to improve the performance of a panel combination in the HIV− groups, and 23 of the 89 (26%) of the candidates assayed did the same in the HIV+ groups. Furthermore, the performance gained with each additional biomarker candidate became progressively smaller (Table s 3 and 4). These results indicated that it was possible to increase the overall test performance by using small combinations of individual biomarkers, and that large biomarker panels were not necessary to achieve this performance.

TABLE 3 HIV− panels Active TB vs pneumonia, HIV− accuracy auc CD14 APOE + none + none = 0.95 0.977 + SELL + none = 0.95 0.984 + TNXB = 0.95 1.000 + COMP = 0.93 0.989 + LUM = 0.93 0.989 + PGLYRP2 = 0.95 0.989 + HABP2 = 0.93 0.986 + LRG1 = 0.95 0.986 + QSOX1 = 0.93 0.986 + S100A8 = 0.95 0.986 CD14 APOE + APOC3 + none = 0.93 0.979 + PGLYRP2 = 0.93 0.991 + SELL = 0.93 0.989 + HABP2 = 0.93 0.986

TABLE 4 HIV+ panels Active TB vs pneumonia, HIV+ accuracy auc LCP1 VASN PFN1 + none = 0.94 0.980 + IGFBP6 = 0.94 1.000 + LRG1 = 0.94 1.000 + PGLYRP2 = 0.91 0.996 + APOA4 = 0.94 0.992 + BCHE = 0.94 0.992 + PI16 = 0.94 0.988 + SEPP1 = 0.94 0.988 + APOA1 = 0.94 0.984 + IGFALS = 0.91 0.984 + CD14 = 0.980 + TAGLN2 = 0.94 0.984 LCP1 VASN TAGLN2 + none = 0.94 0.965 + IGFBP6 = 0.97 1.000 + LRG1 = 0.94 1.000 + SEPP1 = 0.97 0.984 LCP1 VASN PGLYRP2 + none = 0.94 0.925 + PFN1 = 0.94 0.984 + TAGLN2 = 0.94 0.984 PFN1 PI16 PON1 PTGDS + none = 0.91 0.992

The panel combinations able to distinguish TB from ORDs differed dependent on the HIV co-infection background. The composition of the panels in HIV+ subjects differed from that of the panels in HIV− subjects. Although the sizes of the panels were similar independent of HIV background, two combinations of 4 proteins were able to perfectly separate the HIV+TB group from the HIV+ ORDs (Table 4). None of the biomarkers in these panels, however, had individual performances comparable to the strong individual performance of CD14 in the HIV− samples, indicating that these particular panels benefited substantially more from biomarker complementarity.

This data demonstrated that modestly sized panels of protein biomarkers that reflect the physiological changes in the host during an active TB infection can be used to identify active TB, and to distinguish the disease from similarly presenting pneumonias in the presence or absence of an HIV co-infection.

TABLE 2A Marker Discovery Active TB vs LTBI (HIV−) Active TB vs LTBI (HIV+) Active TB vs LTBI (HIV− and HIV+) PROTEIN #PEPTIDES q-value DE ANOVA DI p-value DE ANOVA DI p-value DE ANOVA DI p-value A1BG 3 0.031 0.85 0.208 1.09 0.495 0.96 0.658 A2M 119 0.000 1.22 0.000 0.84 0.000 1.02 0.286 ABI3BP 7 0.062 0.96 0.650 0.90 0.220 0.94 0.246 ACTN1 0 — — — — — — — ADAMTS13 5 0.000 0.71 0.000 0.91 0.313 0.80 0.001 ADAMTSL4 1 0.041 0.84 0.342 0.97 0.892 0.90 0.448 AFM 6 0.000 X 0.42 0.000 0.56 0.000 X 0.48 0.000 AGT 25 0.000 0.86 0.002 0.96 0.471 0.91 0.007 AHSG 2 0.062 1.23 0.214 1.22 0.238 1.22 0.087 ALB 12 0.020 0.98 0.840 1.10 0.240 1.04 0.517 ALCAM 5 0.140 1.03 0.731 1.05 0.643 1.04 0.573 ALDOA 6 0.016 1.06 0.582 1.02 0.891 1.04 0.625 ALDOB 6 0.000 0.61 0.000 0.73 0.020 0.66 0.000 AMBP 12 0.096 0.95 0.528 0.95 0.558 0.95 0.394 ANGPTL3 3 0.007 1.19 0.135 0.90 0.405 1.05 0.614 ANPEP 9 0.005 1.04 0.640 0.90 0.167 0.97 0.552 AOC3 3 0.087 1.22 0.126 1.10 0.499 1.16 0.117 APCS 5 0.000 1.46 0.002 1.22 0.118 1.34 0.001 APOA1 42 0.000 0.60 0.000 0.63 0.000 0.62 0.000 APOA2 6 0.000 0.62 0.000 0.63 0.000 0.63 0.000 APOA4 149 0.000 X 0.50 0.000 0.51 0.000 0.50 0.000 APOB 262 0.000 0.75 0.000 0.78 0.000 0.76 0.000 APOC1 7 0.000 0.50 0.000 X 0.48 0.000 X 0.49 0.000 APOC2 6 0.000 X 0.33 0.000 X 0.31 0.000 X 0.32 0.000 APOC3 12 0.000 X 0.38 0.000 X 0.34 0.000 X 0.36 0.000 APOC4 8 0.000 X 0.33 0.000 X 0.28 0.000 X 0.30 0.000 APOD 3 0.011 0.85 0.164 0.79 0.048 0.83 0.018 APOE 47 0.000 0.56 0.000 X 0.42 0.000 X 0.49 0.000 APOF 3 0.032 0.89 0.380 1.06 0.666 0.97 0.733 APOL1 9 0.066 1.14 0.188 1.09 0.375 1.12 0.120 APOM 3 0.000 0.58 0.000 0.65 0.008 0.61 0.000 APP 6 0.021 0.97 0.764 1.16 0.101 1.06 0.375 ARHGDIB 3 0.000 1.30 0.071 1.26 0.124 1.28 0.024 ARPC5 0 — — — — — — — ATP6AP1L 0 — — — — — — — ATRN 26 0.000 0.78 0.000 0.81 0.000 0.79 0.000 AXL 1 0.084 0.74 0.282 0.70 0.229 0.72 0.105 AZGP1 40 0.000 1.11 0.002 1.24 0.000 1.17 0.000 B2M 16 0.000 1.36 0.000 1.17 0.009 1.27 0.000 B4GALT1 1 0.161 1.25 0.331 1.15 0.569 1.20 0.265 BCHE 12 0.000 0.76 0.000 0.76 0.000 0.76 0.000 BLVRB 1 0.096 1.13 0.703 1.06 0.861 1.09 0.687 BST1 4 0.023 1.11 0.341 1.20 0.101 1.15 0.073 BTD 7 0.028 0.78 0.050 0.86 0.246 0.82 0.027 C1R 66 0.020 1.00 0.938 1.03 0.428 1.01 0.554 C1RL 21 0.047 1.06 0.317 1.01 0.890 1.04 0.414 C1S 57 0.003 0.93 0.011 0.97 0.376 0.95 0.015 C2 44 0.000 1.08 0.029 0.98 0.598 1.03 0.223 C3 3 0.054 1.16 0.367 1.05 0.775 1.11 0.397 C4BPA 3 0.003 1.28 0.036 1.24 0.076 1.26 0.007 C5 2 0.003 1.26 0.111 0.98 0.871 1.11 0.314 C6 0 — — — — — — — C9 0 — — — — — — — CA1 7 0.000 1.35 0.071 1.00 0.998 1.17 0.195 CA2 3 0.000 1.46 0.093 1.33 0.217 1.40 0.043 CACNA2D1 5 0.000 0.74 0.001 0.90 0.242 0.81 0.002 CALM1 0 — — — — — — — CALU 2 0.074 1.06 0.744 1.29 0.168 1.16 0.240 CAT 5 0.000 1.10 0.439 1.11 0.401 1.11 0.270 CCDC149 1 0.000 0.54 0.007 0.58 0.021 0.56 0.000 CD14 19 0.000 1.21 0.000 1.09 0.096 1.15 0.000 CD163 6 0.000 1.27 0.019 1.20 0.079 1.24 0.004 CD44 4 0.055 0.94 0.637 0.89 0.395 0.92 0.358 CD59 1 0.074 1.17 0.264 1.21 0.194 1.19 0.084 CD5L 14 0.000 1.36 0.000 1.96 0.000 1.62 0.000 CD84 1 0.006 1.18 0.524 1.18 0.537 1.18 0.411 CD93 3 0.074 0.92 0.514 0.90 0.401 0.91 0.296 CDH1 4 0.024 1.05 0.683 1.01 0.942 1.03 0.730 CDH13 4 0.000 0.67 0.001 0.79 0.051 0.72 0.000 CDH2 1 0.046 0.74 0.193 0.69 0.132 0.72 0.047 CDH5 9 0.003 1.03 0.687 0.97 0.620 1.00 0.965 CETP 1 0.085 0.77 0.347 0.70 0.213 0.74 0.121 CFB 0 — — — — — — — CFD 10 0.000 0.81 0.001 0.86 0.014 0.83 0.000 CFL1 0 — — — — — — — CFP 1 0.179 0.92 0.660 0.87 0.448 0.90 0.394 CHI3L1 1 0.000 X 2.07 0.003 X 2.16 0.003 X 2.11 0.000 CHL1 15 0.001 0.97 0.608 0.93 0.261 0.95 0.261 CKM 3 0.000 0.63 0.004 0.62 0.004 0.62 0.000 CLC 1 0.113 1.09 0.742 1.33 0.263 1.20 0.313 CLEC3B 25 0.000 0.70 0.000 0.71 0.000 0.70 0.000 CLIC1 0 — — — — — — — CLU 50 0.001 0.98 0.612 0.94 0.083 0.96 0.124 CNDP1 32 0.000 0.62 0.000 0.95 0.349 0.76 0.000 CNN2 1 0.000 1.28 0.434 1.29 0.427 1.29 0.328 CNTN1 7 0.000 0.79 0.005 1.01 0.867 0.89 0.062 COL18A1 2 0.134 0.80 0.254 0.87 0.495 0.83 0.194 COL6A1 3 0.089 0.85 0.197 0.95 0.710 0.90 0.237 COL6A3 10 0.000 0.82 0.000 0.94 0.307 0.87 0.001 COLEC10 2 0.007 0.87 0.217 0.84 0.137 0.85 0.055 COLEC11 6 0.001 0.87 0.064 0.82 0.010 0.85 0.002 COMP 5 0.000 0.77 0.002 0.64 0.000 0.70 0.000 CORO1A 2 0.000 1.62 0.010 1.42 0.067 1.52 0.004 CORO1B 1 0.206 1.14 0.671 1.11 0.744 1.12 0.588 COTL1 1 0.007 1.19 0.553 1.39 0.284 1.28 0.281 CP 3 0.000 1.77 0.000 1.07 0.670 1.39 0.007 CPB2 20 0.205 1.00 0.960 1.02 0.637 1.01 0.722 CPN1 21 0.140 1.03 0.547 1.02 0.713 1.02 0.493 CPN2 17 0.000 0.85 0.021 0.85 0.027 0.85 0.002 CPQ 1 0.005 0.95 0.822 0.61 0.026 0.77 0.109 CRP 3 0.000 X 4.45 0.000 X 2.22 0.003 X 3.20 0.000 CRTAC1 8 0.000 0.62 0.000 0.62 0.000 0.62 0.000 CSF1R 3 0.048 0.85 0.244 0.87 0.321 0.86 0.130 CST3 6 0.005 1.10 0.344 1.15 0.183 1.12 0.113 CTBS 9 0.000 0.74 0.000 0.65 0.000 0.70 0.000 CTSD 1 0.042 1.09 0.738 0.85 0.539 0.97 0.866 DAG1 3 0.057 0.98 0.821 0.97 0.740 0.97 0.698 DBH 7 0.020 0.83 0.181 0.94 0.660 0.88 0.208 DPEP2 1 0.113 0.86 0.533 1.00 0.989 0.93 0.657 DPP4 1 0.041 0.89 0.429 1.15 0.382 1.00 0.985 DSG2 1 0.066 0.92 0.559 1.00 0.985 0.95 0.666 ECM1 12 0.000 1.04 0.606 1.15 0.053 1.09 0.095 ENDOD1 1 0.147 0.77 0.263 0.89 0.643 0.83 0.253 ENG 1 0.085 1.34 0.329 0.99 0.981 1.16 0.487 ENO1 3 0.000 1.20 0.164 1.27 0.073 1.23 0.034 ENPP2 7 0.000 1.18 0.112 0.80 0.043 0.98 0.829 ERAP1 1 0.192 1.02 0.888 1.02 0.887 1.02 0.839 F10 19 0.000 0.99 0.802 1.01 0.900 1.00 0.923 F11 12 0.001 0.91 0.089 0.93 0.207 0.92 0.038 F12 23 0.000 0.63 0.000 0.63 0.000 0.63 0.000 F13A1 6 0.000 0.81 0.060 0.56 0.000 0.68 0.000 F13B 13 0.000 0.99 0.848 0.86 0.019 0.92 0.086 F2 16 0.089 1.02 0.714 1.06 0.369 1.04 0.383 F5 24 0.006 1.04 0.450 1.11 0.051 1.07 0.062 F7 5 0.000 0.75 0.003 0.68 0.000 0.72 0.000 F9 16 0.000 0.80 0.001 0.72 0.000 0.76 0.000 FAH 1 0.003 0.80 0.472 0.51 0.031 0.64 0.050 FAM3C 1 0.144 0.98 0.903 1.10 0.546 1.04 0.744 FBLN1 8 0.000 0.84 0.012 0.86 0.048 0.85 0.002 FBXO33 0 — — — — — — — FCGBP 12 0.000 1.19 0.004 1.08 0.240 1.14 0.005 FCGR3A 5 0.000 1.41 0.006 1.47 0.003 1.44 0.000 FCGR3B 4 0.000 1.46 0.008 0.95 0.736 1.19 0.103 FCN2 11 0.000 1.05 0.452 0.96 0.524 1.01 0.911 FCN3 13 0.172 0.94 0.410 1.00 0.992 0.97 0.556 FETUB 13 0.000 1.32 0.000 0.82 0.004 1.05 0.311 FGA 19 0.000 1.42 0.000 1.84 0.000 1.60 0.000 FGB 0 — — — — — — — FGFR1 1 0.132 0.87 0.571 1.00 0.984 0.93 0.687 FGG 0 — — — — — — — FKBP1A 1 0.039 1.20 0.432 1.24 0.364 1.22 0.248 FLNA 10 0.000 1.42 0.003 1.28 0.046 1.35 0.001 FLT4 1 0.203 1.07 0.728 0.93 0.694 1.00 0.988 FN1 3 0.022 1.21 0.204 0.89 0.454 1.05 0.683 FTL 2 0.002 1.00 0.991 1.30 0.317 1.13 0.502 FUCA1 1 0.138 1.21 0.591 0.90 0.776 1.05 0.843 FUCA2 1 0.015 1.19 0.411 0.91 0.669 1.05 0.774 GALNT2 1 0.089 1.02 0.939 1.25 0.326 1.12 0.467 GAPDH 2 0.003 0.93 0.690 0.93 0.699 0.93 0.595 GC 1 0.096 0.76 0.168 0.87 0.482 0.81 0.133 GGH 9 0.000 1.31 0.000 0.86 0.025 1.07 0.150 GK 0 — — — — — — — GNPTG 2 0.100 0.92 0.505 1.01 0.921 0.96 0.676 GOSR1 0 — — — — — — — GP1BA 9 0.000 1.02 0.795 1.35 0.000 1.16 0.002 GP5 6 0.006 0.90 0.266 1.17 0.105 1.02 0.772 GPLD1 18 0.000 0.73 0.000 0.71 0.000 0.72 0.000 GPR126 1 0.148 0.88 0.395 0.91 0.574 0.89 0.311 GPX3 16 0.000 0.94 0.290 1.14 0.024 1.03 0.451 GSN 58 0.000 0.63 0.000 0.66 0.000 0.64 0.000 GSTO1 1 0.001 1.46 0.032 1.08 0.689 1.26 0.084 GSTP1 0 — — — — — — — HABP2 7 0.042 0.98 0.803 0.85 0.068 0.92 0.157 HBA1 11 0.000 X 2.11 0.000 1.79 0.000 1.95 0.000 HBB 6 0.000 X 2.03 0.000 1.80 0.001 1.91 0.000 HEG1 1 0.208 0.91 0.559 0.99 0.962 0.95 0.643 HGFAC 16 0.004 0.84 0.024 0.97 0.698 0.90 0.058 HIST1H4A 5 0.000 1.73 0.000 1.25 0.132 1.48 0.000 HP 39 0.000 X 3.01 0.000 X 2.97 0.000 X 2.99 0.000 HPR 10 0.000 1.76 0.000 1.56 0.000 1.66 0.000 HPX 2 0.207 0.94 0.695 1.05 0.773 0.99 0.929 HRNR 7 0.000 1.20 0.203 1.36 0.037 1.28 0.022 HSP90B1 4 0.021 0.87 0.252 0.77 0.039 0.82 0.026 HSPA5 10 0.052 1.02 0.774 1.00 0.976 1.01 0.852 HSPA8 0 — — — — — — — HSPB1 0 — — — — — — — HSPG2 9 0.000 0.89 0.108 1.01 0.902 0.95 0.284 HYOU1 3 0.060 0.85 0.214 0.97 0.825 0.91 0.296 ICAM1 5 0.000 1.45 0.000 1.16 0.109 1.31 0.000 ICAM2 1 0.206 1.06 0.740 1.06 0.736 1.06 0.632 ICOSLG 1 0.050 0.80 0.103 0.98 0.892 0.88 0.210 IDH1 1 0.003 1.58 0.030 1.20 0.392 1.39 0.034 IGF1 2 0.002 0.80 0.171 0.95 0.759 0.86 0.245 IGF2 5 0.000 0.66 0.000 0.81 0.040 0.73 0.000 IGF2R 1 0.062 1.05 0.758 1.09 0.610 1.07 0.565 IGFALS 37 0.000 0.75 0.000 0.95 0.207 0.84 0.000 IGFBP1 1 0.154 0.74 0.373 0.75 0.399 0.75 0.213 IGFBP2 6 0.000 X 2.49 0.000 1.99 0.000 X 2.23 0.000 IGFBP3 13 0.000 0.73 0.000 0.98 0.795 0.84 0.001 IGFBP4 1 0.124 1.22 0.479 0.91 0.734 1.06 0.777 IGFBP5 3 0.000 0.78 0.021 0.99 0.959 0.88 0.104 IGFBP6 2 0.006 0.81 0.061 1.07 0.564 0.92 0.349 IGFBP7 1 0.181 0.89 0.467 1.04 0.811 0.96 0.712 IGLL5 19 0.000 1.94 0.000 1.87 0.000 1.91 0.000 IL1R2 1 0.030 0.87 0.323 0.75 0.060 0.81 0.045 IL1RAP 7 0.000 0.77 0.004 1.08 0.420 0.90 0.136 IL6ST 3 0.134 1.26 0.256 1.08 0.697 1.17 0.276 ISLR 3 0.013 0.79 0.024 0.92 0.428 0.85 0.031 ITGB1 1 0.083 0.82 0.335 0.75 0.174 0.79 0.098 ITIH1 2 0.161 1.17 0.344 1.16 0.390 1.16 0.200 ITIH2 3 0.079 0.85 0.185 0.91 0.467 0.88 0.147 ITIH3 17 0.000 1.71 0.000 1.48 0.000 1.60 0.000 ITIH4 59 0.000 1.34 0.000 1.35 0.000 1.34 0.000 KIT 2 0.000 0.72 0.059 0.67 0.025 0.70 0.004 KLKB1 14 0.000 0.84 0.004 0.89 0.062 0.86 0.001 KNG1 7 0.019 1.16 0.405 1.39 0.074 1.26 0.071 KRT1 30 0.000 1.11 0.166 1.08 0.348 1.10 0.104 KRT10 8 0.018 1.22 0.175 1.30 0.074 1.26 0.028 KRT14 3 0.198 0.95 0.730 1.01 0.931 0.98 0.848 KRT2 11 0.000 1.41 0.009 1.30 0.051 1.36 0.001 KRT5 1 0.088 1.47 0.263 1.39 0.358 1.43 0.144 KRT9 16 0.000 1.24 0.055 1.18 0.160 1.21 0.021 LAMB1 1 0.116 0.88 0.388 0.84 0.253 0.86 0.153 LAMP1 2 0.089 0.90 0.411 0.93 0.582 0.92 0.333 LAMP2 2 0.198 0.92 0.623 0.92 0.625 0.92 0.487 LASP1 1 0.034 0.97 0.912 1.12 0.674 1.04 0.844 LBP 1 0.000 1.69 0.010 1.61 0.023 1.65 0.001 LCAT 18 0.000 0.77 0.000 0.75 0.000 0.76 0.000 LCN2 2 0.082 1.24 0.269 1.18 0.395 1.21 0.166 LCP1 12 0.000 1.43 0.000 1.27 0.000 1.35 0.000 LDHB 3 0.126 1.00 0.995 1.04 0.773 1.02 0.841 LGALS3BP 28 0.000 0.95 0.331 0.79 0.000 0.87 0.001 LGALSL 2 0.000 1.43 0.037 1.29 0.155 1.36 0.031 LILRA1 1 0.062 0.81 0.611 0.60 0.229 0.70 0.242 LILRA3 1 0.039 1.21 0.548 0.89 0.739 1.05 0.841 LPA 16 0.000 1.02 0.803 1.33 0.005 1.16 0.036 LRG1 45 0.000 1.73 0.000 1.49 0.000 1.61 0.000 LRP1 4 0.192 1.00 0.980 1.04 0.710 1.02 0.786 LSAMP 1 0.074 0.87 0.398 1.08 0.651 0.97 0.766 LUM 34 0.000 0.78 0.000 0.83 0.000 0.80 0.000 LYVE1 4 0.054 0.92 0.410 0.99 0.947 0.95 0.522 LYZ 2 0.003 1.51 0.015 1.01 0.948 1.25 0.079 MAN1A1 5 0.001 1.28 0.008 1.01 0.938 1.14 0.051 MAN2A2 1 0.179 0.96 0.806 1.03 0.867 0.99 0.948 MASP1 17 0.000 0.84 0.000 0.84 0.000 0.84 0.000 MASP2 8 0.135 0.95 0.496 0.99 0.912 0.97 0.571 MB 1 0.005 0.63 0.015 0.73 0.100 0.67 0.004 MBL2 4 0.008 1.01 0.928 1.08 0.574 1.04 0.658 MCAM 1 0.013 0.63 0.031 0.82 0.354 0.71 0.028 MEGF8 2 0.217 0.94 0.678 1.02 0.918 0.97 0.816 MIF 0 — — — — — — — MINPP1 2 0.149 0.89 0.440 0.96 0.797 0.93 0.462 MMP2 3 0.000 0.60 0.000 0.65 0.000 0.62 0.000 MMP9 2 0.000 1.98 0.000 1.75 0.003 1.87 0.000 MMRN2 1 0.075 0.80 0.266 1.02 0.919 0.90 0.465 MRPS26 1 0.055 0.88 0.642 0.63 0.091 0.75 0.139 MSN 3 0.000 1.17 0.260 1.07 0.621 1.12 0.287 MST1 15 0.000 1.01 0.873 0.86 0.032 0.94 0.189 MTPN 1 0.005 0.97 0.933 0.96 0.915 0.96 0.903 NAGLU 3 0.005 1.05 0.681 0.84 0.147 0.94 0.506 NCAM1 2 0.096 0.84 0.239 0.99 0.924 0.91 0.360 NEO1 1 0.024 0.74 0.081 0.78 0.164 0.76 0.025 NID1 7 0.000 1.15 0.064 1.24 0.004 1.19 0.001 NRGN 1 0.013 1.02 0.952 0.94 0.833 0.98 0.924 NRP1 3 0.013 1.13 0.245 1.20 0.096 1.17 0.051 NUCB1 1 0.060 1.36 0.256 1.53 0.123 1.44 0.058 NUP210L 1 0.011 1.64 0.153 X 2.09 0.038 1.84 0.015 OAF 2 0.000 1.16 0.134 1.27 0.022 1.21 0.008 OLFM1 2 0.093 0.92 0.587 1.01 0.955 0.96 0.722 ORM1 10 0.000 X 2.21 0.000 1.59 0.000 1.89 0.000 ORM2 10 0.000 1.95 0.000 1.29 0.013 1.61 0.000 PAM 1 0.158 1.17 0.376 1.09 0.637 1.13 0.329 PCOLCE 4 0.000 0.74 0.001 0.84 0.061 0.78 0.000 PCSK9 3 0.011 0.77 0.050 0.78 0.064 0.77 0.007 PDIA3 2 0.021 1.19 0.155 1.21 0.128 1.20 0.039 PDLIM1 3 0.000 1.37 0.178 1.54 0.075 1.45 0.048 PEPD 9 0.000 0.73 0.000 0.74 0.000 0.73 0.000 PF4 11 0.000 0.87 0.028 1.14 0.043 0.99 0.831 PFN1 7 0.000 1.32 0.012 1.33 0.013 1.33 0.002 PGLYRP2 28 0.000 0.68 0.000 0.69 0.000 0.68 0.000 PI16 6 0.000 0.50 0.000 0.66 0.003 0.57 0.000 PIGR 1 0.047 1.39 0.159 0.98 0.934 1.18 0.342 PLEK 1 0.005 0.91 0.808 0.94 0.871 0.92 0.791 PLS1 1 0.031 1.39 0.079 1.25 0.242 1.32 0.036 PLTP 3 0.001 1.58 0.005 1.26 0.160 1.42 0.003 PLXNB1 2 0.011 1.12 0.352 1.23 0.109 1.17 0.078 PODXL 1 0.218 0.96 0.816 0.93 0.657 0.94 0.631 PON1 5 0.003 0.77 0.012 0.89 0.286 0.82 0.011 PON3 0 — — — — — — — POR 0 — — — — — — — POSTN 2 0.074 1.00 0.985 1.15 0.359 1.07 0.527 PPBP 23 0.000 1.04 0.470 1.20 0.001 1.11 0.007 PPIA 5 0.000 1.65 0.000 1.78 0.000 1.71 0.000 PPIB 1 0.027 1.31 0.175 1.38 0.119 1.34 0.041 PRAP1 1 0.017 0.70 0.158 0.67 0.129 0.69 0.037 PRDX2 6 0.000 1.47 0.009 1.16 0.331 1.31 0.012 PRDX6 1 0.028 1.35 0.251 1.28 0.350 1.32 0.139 PRG4 5 0.000 1.16 0.180 1.08 0.502 1.12 0.162 PROC 9 0.014 0.88 0.079 0.90 0.136 0.89 0.022 PROCR 4 0.071 0.87 0.240 0.91 0.457 0.89 0.177 PROS1 14 0.000 0.76 0.000 0.89 0.076 0.82 0.000 PROZ 12 0.000 0.87 0.121 0.78 0.008 0.83 0.004 PRSS1 1 0.203 1.07 0.763 1.19 0.456 1.13 0.459 PRSS3 1 0.202 1.02 0.920 1.11 0.662 1.06 0.707 PTGDS 2 0.189 1.05 0.784 1.15 0.439 1.10 0.466 PTPRG 1 0.000 0.59 0.015 0.63 0.038 0.61 0.001 PTPRJ 4 0.003 0.84 0.033 0.84 0.049 0.84 0.004 PTPRS 1 0.203 0.94 0.736 0.99 0.955 0.96 0.774 PVR 6 0.021 0.96 0.662 1.00 0.965 0.98 0.776 PVRL1 1 0.221 0.95 0.757 0.97 0.880 0.96 0.738 PZP 8 0.000 1.36 0.032 1.01 0.955 1.18 0.117 QSOX1 11 0.000 0.86 0.009 0.78 0.000 0.82 0.000 RBBP8 1 0.027 2.05 0.114 2.31 0.075 X 2.17 0.016 RNASE1 1 0.207 1.13 0.637 1.16 0.597 1.15 0.473 RTN4RL2 1 0.006 0.71 0.015 0.84 0.247 0.77 0.011 S100A12 2 0.002 1.21 0.404 0.96 0.867 1.08 0.640 S100A8 9 0.000 1.43 0.001 1.51 0.000 1.47 0.000 S100A9 18 0.000 1.85 0.000 1.83 0.000 1.84 0.000 SAA1 4 0.000 X 2.49 0.000 X 2.19 0.001 X 2.34 0.000 SAA4 14 0.000 0.83 0.014 0.71 0.000 0.77 0.000 SDPR 1 0.006 1.39 0.322 1.46 0.270 1.42 0.166 SELL 8 0.000 1.13 0.107 1.14 0.106 1.13 0.025 SEMA4B 1 0.014 0.75 0.157 0.68 0.067 0.72 0.024 SEPP1 8 0.001 0.80 0.006 0.83 0.033 0.81 0.001 SERPINA1 78 0.000 1.94 0.000 1.37 0.000 1.65 0.000 SERPINA10 16 0.000 0.95 0.390 0.76 0.000 0.85 0.000 SERPINA3 6 0.000 1.66 0.000 1.56 0.000 1.61 0.000 SERPINA4 22 0.000 0.56 0.000 0.59 0.000 0.57 0.000 SERPINA6 14 0.004 1.03 0.708 0.91 0.192 0.97 0.542 SERPINA7 37 0.000 0.95 0.207 0.77 0.000 0.86 0.000 SERPINB1 1 0.000 1.51 0.057 1.41 0.119 1.46 0.026 SERPINC1 1 0.007 1.79 0.025 1.51 0.126 1.65 0.007 SERPIND1 25 0.000 0.90 0.060 0.82 0.000 0.86 0.000 SERPINF1 41 0.000 0.73 0.000 0.78 0.000 0.76 0.000 SERPINF2 1 0.039 1.48 0.082 1.28 0.282 1.38 0.044 SERPING1 15 0.005 0.85 0.016 0.94 0.389 0.90 0.021 SH3BGRL 1 0.000 1.70 0.021 1.65 0.033 1.68 0.003 SH3BGRL3 3 0.000 1.59 0.014 1.67 0.008 1.62 0.001 SHBG 16 0.000 1.09 0.314 0.71 0.000 0.89 0.073 SLC3A2 2 0.000 0.57 0.000 0.60 0.001 0.58 0.000 SNCA 0 — — — — — — — SNED1 1 0.119 1.13 0.489 0.99 0.963 1.06 0.640 SOD3 5 0.004 0.94 0.538 0.76 0.011 0.85 0.031 SORL1 2 0.089 1.07 0.813 1.16 0.590 1.11 0.594 SOWAHC 0 — — — — — — — SPARC 11 0.000 1.02 0.739 1.36 0.000 1.17 0.002 SPARCL1 2 0.042 0.91 0.533 1.11 0.498 1.00 0.994 SPP2 2 0.000 0.61 0.004 0.55 0.001 0.58 0.000 SRGN 3 0.017 1.01 0.942 1.24 0.071 1.11 0.208 SSC5D 2 0.049 0.99 0.950 0.84 0.363 0.91 0.513 STXBP3 0 — — — — — — — TAGLN2 7 0.000 1.65 0.000 1.76 0.000 1.70 0.000 TF 8 0.001 0.84 0.080 0.96 0.702 0.89 0.128 TGFBI 14 0.000 0.87 0.046 0.95 0.493 0.91 0.059 THBS1 30 0.000 0.76 0.000 0.96 0.458 0.85 0.000 TIMP1 1 0.181 0.98 0.917 1.20 0.419 1.08 0.632 TKT 3 0.000 1.43 0.016 1.35 0.050 1.39 0.002 TLN1 11 0.000 1.18 0.048 1.22 0.026 1.20 0.005 TMSB4X 6 0.000 1.51 0.006 1.45 0.017 1.48 0.001 TNC 5 0.205 1.01 0.957 1.05 0.667 1.03 0.741 TNXB 19 0.000 0.83 0.000 0.84 0.000 0.83 0.000 TPI1 2 0.001 1.38 0.055 1.22 0.250 1.30 0.036 TPM3 3 0.000 1.25 0.156 1.27 0.139 1.26 0.062 TPM4 1 0.072 1.00 0.994 1.11 0.760 1.05 0.844 TREML1 3 0.000 1.40 0.043 1.79 0.001 1.57 0.000 TTR 4 0.208 0.92 0.551 1.00 0.987 0.96 0.673 TUBA4A 2 0.003 1.30 0.075 1.31 0.075 1.30 0.014 UMOD 1 0.066 1.17 0.298 1.16 0.328 1.16 0.147 VASN 7 0.072 0.90 0.108 0.95 0.435 0.92 0.090 VASP 1 0.003 1.16 0.522 1.21 0.428 1.18 0.348 VCAM1 12 0.007 1.10 0.161 1.02 0.816 1.06 0.241 VCL 5 0.008 1.10 0.364 1.21 0.079 1.15 0.067 VIM 2 0.219 0.94 0.804 0.95 0.842 0.94 0.750 VNN1 4 0.001 0.63 0.006 0.86 0.368 0.73 0.010 VTN 4 0.027 0.86 0.159 0.82 0.061 0.84 0.022 VWF 60 0.000 1.05 0.192 0.93 0.057 0.99 0.729 YWHAE 0 — — — — — — — YWHAG 0 — — — — — — — YWHAZ 0 — — — — — — — ZYX 3 0.000 1.58 0.093 1.71 0.054 1.64 0.021 *Differential expression (DE) thresholds: p-value < 0.05 | q-value < 0.05 | ANOVA DI > 2

TABLE 2B Marker Discovery *Differential expression (DE) thresholds: p-value <0.05|q-value <0.05|ANOVA DI >2 Active TB vs Active TB vs Asymptomatic Asymptomatic (HIV−) Asymptomatic (HIV+) (HIV− and HIV+) ANOVA ANOVA ANOVA PROTEIN #PEPTIDES q-value DE DI p-value DE DI p-value DE DI p-value A1BG 3 0.031 0.96 0.750 1.09 0.518 1.02 0.821 A2M 119 0.000 0.74 0.000 0.87 0.000 0.80 0.000 ABI3BP 7 0.062 1.04 0.639 1.03 0.753 1.03 0.581 ACTN1 0 — — — — — — — ADAMTS13 5 0.000 0.80 0.013 0.90 0.239 0.85 0.012 ADAMTSL4 1 0.041 0.75 0.118 1.02 0.898 0.87 0.326 AFM 6 0.000 0.62 0.000 0.50 0.000 0.56 0.000 AGT 25 0.000 0.86 0.003 0.82 0.000 0.84 0.000 AHSG 2 0.062 1.28 0.142 1.15 0.413 1.21 0.104 ALB 12 0.020 1.16 0.078 1.06 0.485 1.11 0.084 ALCAM 5 0.140 1.12 0.249 1.08 0.437 1.10 0.173 ALDOA 6 0.016 1.27 0.034 1.04 0.733 1.15 0.085 ALDOB 6 0.000 0.94 0.625 0.64 0.001 0.78 0.009 AMBP 12 0.096 1.07 0.442 0.96 0.659 1.01 0.818 ANGPTL3 3 0.007 1.16 0.232 0.97 0.818 1.06 0.510 ANPEP 9 0.005 0.89 0.117 0.89 0.112 0.89 0.027 AOC3 3 0.087 1.06 0.671 1.10 0.475 1.08 0.422 APCS 5 0.000 1.85 0.000 1.32 0.031 1.56 0.000 APOA1 42 0.000 X 0.47 0.000 0.69 0.000 0.57 0.000 APOA2 6 0.000 0.59 0.000 0.70 0.000 0.64 0.000 APOA4 149 0.000 0.55 0.000 0.66 0.000 0.60 0.000 APOB 262 0.000 0.92 0.000 0.76 0.000 0.83 0.000 APOC1 7 0.000 0.69 0.010 X 0.50 0.000 0.59 0.000 APOC2 6 0.000 0.62 0.002 X 0.33 0.000 X 0.45 0.000 APOC3 12 0.000 0.63 0.000 X 0.33 0.000 X 0.45 0.000 APOC4 8 0.000 0.55 0.000 X 0.31 0.000 X 0.41 0.000 APOD 3 0.011 0.82 0.084 0.82 0.086 0.82 0.015 APOE 47 0.000 0.78 0.000 X 0.44 0.000 0.59 0.000 APOF 3 0.032 1.19 0.192 1.04 0.770 1.11 0.264 APOL1 9 0.066 1.10 0.338 1.16 0.142 1.13 0.087 APOM 3 0.000 0.89 0.465 0.63 0.003 0.75 0.012 APP 6 0.021 1.07 0.434 0.97 0.758 1.02 0.741 ARHGDIB 3 0.000 1.35 0.044 0.84 0.261 1.07 0.548 ARPC5 0 — — — — — — — ATP6AP1L 0 — — — — — — — ATRN 26 0.000 0.84 0.000 0.76 0.000 0.80 0.000 AXL 1 0.084 0.71 0.241 0.87 0.633 0.79 0.237 AZGP1 40 0.000 1.06 0.076 1.20 0.000 1.13 0.000 B2M 16 0.000 1.53 0.000 1.27 0.000 1.40 0.000 B4GALT1 1 0.161 1.20 0.445 1.14 0.572 1.17 0.339 BCHE 12 0.000 0.75 0.000 0.68 0.000 0.71 0.000 BLVRB 1 0.096 1.50 0.209 1.36 0.342 1.43 0.112 BST1 4 0.023 0.96 0.700 1.11 0.344 1.03 0.694 BTD 7 0.028 0.85 0.212 0.87 0.280 0.86 0.101 C1R 66 0.020 1.00 0.914 1.06 0.061 1.03 0.214 C1RL 21 0.047 0.98 0.677 1.08 0.193 1.03 0.534 C1S 57 0.003 0.96 0.197 0.99 0.831 0.98 0.291 C2 44 0.000 1.16 0.000 1.04 0.227 1.10 0.000 C3 3 0.054 1.33 0.095 1.18 0.327 1.25 0.062 C4BPA 3 0.003 1.26 0.051 1.03 0.797 1.14 0.123 C5 2 0.003 1.38 0.028 1.03 0.824 1.20 0.102 C6 0 — — — — — — — C9 0 — — — — — — — CA1 7 0.000 1.91 0.000 1.51 0.015 1.70 0.000 CA2 3 0.000 X 2.13 0.001 1.37 0.178 1.71 0.001 CACNA2D1 5 0.000 0.71 0.000 0.95 0.551 0.82 0.004 CALM1 0 — — — — — — — CALU 2 0.074 1.19 0.353 1.23 0.264 1.21 0.149 CAT 5 0.000 1.71 0.000 1.15 0.270 1.40 0.000 CCDC149 1 0.000 0.59 0.027 0.60 0.033 0.60 0.002 CD14 19 0.000 1.12 0.028 1.23 0.000 1.17 0.000 CD163 6 0.000 1.38 0.002 1.13 0.248 1.25 0.003 CD44 4 0.055 1.14 0.323 1.04 0.758 1.09 0.361 CD59 1 0.074 1.20 0.212 1.14 0.362 1.17 0.120 CD5L 14 0.000 0.98 0.852 1.82 0.000 1.34 0.000 CD84 1 0.006 1.32 0.304 0.67 0.128 0.94 0.746 CD93 3 0.074 0.82 0.111 0.89 0.357 0.85 0.076 CDH1 4 0.024 1.21 0.100 1.19 0.132 1.20 0.026 CDH13 4 0.000 0.63 0.000 0.86 0.230 0.73 0.001 CDH2 1 0.046 0.92 0.725 0.76 0.248 0.83 0.282 CDH5 9 0.003 0.94 0.312 1.13 0.068 1.03 0.572 CETP 1 0.085 0.70 0.217 0.84 0.544 0.77 0.188 CFB 0 — — — — — — — CFD 10 0.000 0.93 0.242 0.84 0.004 0.88 0.005 CFL1 0 — — — — — — — CFP 1 0.179 1.01 0.966 1.02 0.927 1.01 0.923 CHI3L1 1 0.000 X 2.36 0.001 1.53 0.096 1.90 0.001 CHL1 15 0.001 1.00 0.974 0.85 0.007 0.92 0.063 CKM 3 0.000 0.82 0.222 0.64 0.008 0.72 0.007 CLC 1 0.113 1.31 0.302 1.20 0.474 1.25 0.213 CLEC3B 25 0.000 0.70 0.000 0.76 0.000 0.73 0.000 CLIC1 0 — — — — — — — CLU 50 0.001 1.03 0.371 1.04 0.231 1.04 0.142 CNDP1 32 0.000 0.64 0.000 0.65 0.000 0.64 0.000 CNN2 1 0.000 1.43 0.268 X 0.49 0.028 0.84 0.495 CNTN1 7 0.000 0.75 0.001 0.90 0.207 0.82 0.002 COL18A1 2 0.134 0.94 0.755 0.85 0.423 0.89 0.429 COL6A1 3 0.089 0.99 0.909 0.87 0.303 0.93 0.421 COL6A3 10 0.000 0.82 0.001 0.91 0.116 0.86 0.001 COLEC10 2 0.007 0.78 0.045 0.78 0.040 0.78 0.004 COLEC11 6 0.001 0.83 0.017 0.90 0.173 0.87 0.008 COMP 5 0.000 0.81 0.017 0.68 0.000 0.74 0.000 CORO1A 2 0.000 1.84 0.002 0.89 0.550 1.28 0.096 CORO1B 1 0.206 0.96 0.895 0.94 0.854 0.95 0.820 COTL1 1 0.007 1.59 0.133 0.73 0.305 1.08 0.754 CP 3 0.000 1.74 0.001 1.24 0.199 1.47 0.002 CPB2 20 0.205 1.01 0.829 0.98 0.727 1.00 0.925 CPN1 21 0.140 0.98 0.683 0.98 0.597 0.98 0.510 CPN2 17 0.000 0.82 0.007 0.82 0.007 0.82 0.000 CPQ 1 0.005 0.77 0.252 0.68 0.088 0.72 0.054 CRP 3 0.000 X 4.41 0.000 X 3.18 0.000 X 3.74 0.000 CRTAC1 8 0.000 0.79 0.002 0.68 0.000 0.73 0.000 CSF1R 3 0.048 1.08 0.575 0.92 0.547 1.00 0.977 CST3 6 0.005 1.30 0.011 1.13 0.252 1.21 0.010 CTBS 9 0.000 0.81 0.001 0.75 0.000 0.78 0.000 CTSD 1 0.042 1.37 0.230 0.86 0.578 1.09 0.662 DAG1 3 0.057 1.02 0.847 1.16 0.160 1.09 0.262 DBH 7 0.020 0.76 0.054 0.96 0.780 0.85 0.123 DPEP2 1 0.113 0.95 0.840 1.23 0.401 1.08 0.652 DPP4 1 0.041 0.89 0.476 0.87 0.382 0.88 0.273 DSG2 1 0.066 0.80 0.138 0.99 0.971 0.89 0.291 ECM1 12 0.000 1.07 0.323 1.24 0.002 1.16 0.005 ENDOD1 1 0.147 0.87 0.550 0.94 0.787 0.90 0.534 ENG 1 0.085 1.45 0.231 1.27 0.448 1.36 0.166 ENO1 3 0.000 1.43 0.007 0.90 0.422 1.13 0.204 ENPP2 7 0.000 1.00 0.984 1.12 0.298 1.06 0.467 ERAP1 1 0.192 1.11 0.477 1.10 0.535 1.10 0.337 F10 19 0.000 1.07 0.089 1.12 0.006 1.10 0.002 F11 12 0.001 0.85 0.006 0.95 0.381 0.90 0.011 F12 23 0.000 0.59 0.000 0.77 0.000 0.67 0.000 F13A1 6 0.000 0.72 0.005 0.88 0.276 0.79 0.007 F13B 13 0.000 0.82 0.002 0.86 0.018 0.84 0.000 F2 16 0.089 1.10 0.153 1.02 0.736 1.06 0.214 F5 24 0.006 1.12 0.032 1.07 0.186 1.10 0.015 F7 5 0.000 0.84 0.083 0.80 0.022 0.82 0.005 F9 16 0.000 0.83 0.005 0.79 0.001 0.81 0.000 FAH 1 0.003 X 0.50 0.028 0.59 0.096 0.54 0.007 FAM3C 1 0.144 1.11 0.498 1.14 0.398 1.12 0.276 FBLN1 8 0.000 0.79 0.002 0.88 0.077 0.83 0.001 FBXO33 0 — — — — — — — FCGBP 12 0.000 1.19 0.007 0.93 0.291 1.05 0.263 FCGR3A 5 0.000 1.69 0.000 1.39 0.010 1.53 0.000 FCGR3B 4 0.000 1.06 0.684 1.45 0.011 1.24 0.046 FCN2 11 0.000 1.10 0.174 1.28 0.000 1.19 0.001 FCN3 13 0.172 0.95 0.489 0.98 0.827 0.96 0.522 FETUB 13 0.000 1.32 0.000 1.09 0.203 1.20 0.000 FGA 19 0.000 1.57 0.000 1.40 0.000 1.48 0.000 FGB 0 — — — — — — — FGFR1 1 0.132 0.76 0.276 0.87 0.562 0.81 0.233 FGG 0 — — — — — — — FKBP1A 1 0.039 1.34 0.221 0.87 0.559 1.08 0.660 FLNA 10 0.000 1.50 0.001 0.69 0.003 1.02 0.841 FLT4 1 0.203 1.05 0.810 1.05 0.797 1.05 0.722 FN1 3 0.022 1.16 0.345 1.15 0.358 1.15 0.196 FTL 2 0.002 1.85 0.018 1.59 0.073 1.71 0.003 FUCA1 1 0.138 1.38 0.373 1.18 0.647 1.28 0.337 FUCA2 1 0.015 1.40 0.119 0.89 0.584 1.12 0.502 GALNT2 1 0.089 1.21 0.402 1.30 0.243 1.25 0.154 GAPDH 2 0.003 1.04 0.830 0.62 0.016 0.80 0.135 GC 1 0.096 0.94 0.747 0.95 0.800 0.94 0.680 GGH 9 0.000 1.40 0.000 1.03 0.686 1.20 0.000 GK 0 — — — — — — — GNPTG 2 0.100 1.11 0.401 1.06 0.636 1.08 0.352 GOSR1 0 — — — — — — — GP1BA 9 0.000 1.18 0.014 0.94 0.339 1.05 0.313 GP5 6 0.006 0.99 0.887 0.97 0.744 0.98 0.745 GPLD1 18 0.000 0.78 0.000 0.67 0.000 0.72 0.000 GPR126 1 0.148 1.04 0.829 0.92 0.622 0.98 0.843 GPX3 16 0.000 1.12 0.046 1.18 0.004 1.15 0.001 GSN 58 0.000 0.62 0.000 0.65 0.000 0.63 0.000 GSTO1 1 0.001 1.58 0.011 1.20 0.319 1.38 0.018 GSTP1 0 — — — — — — — HABP2 7 0.042 0.97 0.716 0.96 0.652 0.97 0.568 HBA1 11 0.000 X 2.49 0.000 1.78 0.000 X 2.10 0.000 HBB 6 0.000 X 2.47 0.000 1.69 0.002 X 2.04 0.000 HEG1 1 0.208 0.95 0.772 1.00 0.993 0.97 0.830 HGFAC 16 0.004 0.88 0.090 0.90 0.156 0.89 0.029 HIST1H4A 5 0.000 1.74 0.000 0.98 0.890 1.31 0.015 HP 39 0.000 X 2.94 0.000 X 2.19 0.000 X 2.53 0.000 HPR 10 0.000 1.61 0.000 1.54 0.000 1.58 0.000 HPX 2 0.207 0.98 0.919 1.04 0.824 1.01 0.932 HRNR 7 0.000 0.89 0.430 1.38 0.030 1.11 0.337 HSP90B1 4 0.021 0.87 0.262 0.84 0.177 0.85 0.082 HSPA5 10 0.052 1.07 0.236 0.95 0.417 1.01 0.794 HSPA8 0 — — — — — — — HSPB1 0 — — — — — — — HSPG2 9 0.000 0.82 0.006 0.92 0.280 0.87 0.007 HYOU1 3 0.060 0.82 0.144 0.95 0.685 0.88 0.191 ICAM1 5 0.000 1.67 0.000 1.38 0.001 1.52 0.000 ICAM2 1 0.206 1.04 0.843 1.13 0.493 1.08 0.525 ICOSLG 1 0.050 0.99 0.964 0.91 0.518 0.95 0.631 IDH1 1 0.003 1.68 0.018 1.36 0.155 1.51 0.008 IGF1 2 0.002 0.63 0.008 0.92 0.639 0.76 0.032 IGF2 5 0.000 0.63 0.000 0.85 0.103 0.73 0.000 IGF2R 1 0.062 1.31 0.099 1.13 0.463 1.21 0.090 IGFALS 37 0.000 0.69 0.000 0.89 0.005 0.79 0.000 IGFBP1 1 0.154 0.76 0.428 0.87 0.674 0.81 0.382 IGFBP2 6 0.000 1.72 0.000 X 2.12 0.000 1.91 0.000 IGFBP3 13 0.000 0.67 0.000 0.98 0.778 0.81 0.000 IGFBP4 1 0.124 0.83 0.515 1.01 0.980 0.91 0.659 IGFBP5 3 0.000 0.73 0.003 0.98 0.885 0.84 0.039 IGFBP6 2 0.006 1.05 0.696 1.02 0.864 1.03 0.701 IGFBP7 1 0.181 0.95 0.757 0.99 0.960 0.97 0.798 IGLL5 19 0.000 1.33 0.001 1.65 0.000 1.48 0.000 IL1R2 1 0.030 0.93 0.630 0.97 0.835 0.95 0.624 IL1RAP 7 0.000 0.68 0.000 0.83 0.051 0.75 0.000 IL6ST 3 0.134 1.22 0.350 1.12 0.582 1.17 0.295 ISLR 3 0.013 0.95 0.641 0.89 0.259 0.92 0.264 ITGB1 1 0.083 0.83 0.385 0.79 0.268 0.81 0.156 ITIH1 2 0.161 1.08 0.644 1.08 0.634 1.08 0.504 ITIH2 3 0.079 0.86 0.237 0.97 0.834 0.92 0.328 ITIH3 17 0.000 1.86 0.000 1.52 0.000 1.68 0.000 ITIH4 59 0.000 1.32 0.000 1.25 0.000 1.29 0.000 KIT 2 0.000 0.54 0.001 0.72 0.061 0.62 0.000 KLKB1 14 0.000 0.87 0.027 0.81 0.001 0.84 0.000 KNG1 7 0.019 1.06 0.731 1.36 0.092 1.20 0.155 KRT1 30 0.000 0.81 0.009 1.09 0.304 0.94 0.269 KRT10 8 0.018 1.13 0.420 1.30 0.074 1.21 0.068 KRT14 3 0.198 0.91 0.503 0.93 0.647 0.92 0.426 KRT2 11 0.000 1.19 0.210 1.39 0.015 1.29 0.010 KRT5 1 0.088 1.29 0.469 1.60 0.185 1.44 0.142 KRT9 16 0.000 0.84 0.124 1.27 0.036 1.03 0.695 LAMB1 1 0.116 0.98 0.907 0.91 0.533 0.95 0.596 LAMP1 2 0.089 0.98 0.861 0.83 0.159 0.90 0.265 LAMP2 2 0.198 0.88 0.459 0.90 0.560 0.89 0.346 LASP1 1 0.034 1.32 0.315 0.73 0.265 0.98 0.941 LBP 1 0.000 1.96 0.001 1.61 0.022 1.78 0.000 LCAT 18 0.000 0.83 0.001 0.73 0.000 0.78 0.000 LCN2 2 0.082 1.06 0.750 0.93 0.713 1.00 0.972 LCP1 12 0.000 1.46 0.000 1.27 0.000 1.36 0.000 LDHB 3 0.126 1.18 0.221 1.05 0.716 1.11 0.263 LGALS3BP 28 0.000 1.25 0.000 0.77 0.000 0.98 0.677 LGALSL 2 0.000 1.53 0.016 0.65 0.017 1.00 0.989 LILRA1 1 0.062 1.07 0.876 0.60 0.236 0.80 0.474 LILRA3 1 0.039 1.32 0.400 0.70 0.289 0.96 0.883 LPA 16 0.000 0.83 0.071 0.80 0.025 0.82 0.005 LRG1 45 0.000 1.78 0.000 1.65 0.000 1.72 0.000 LRP1 4 0.192 1.08 0.421 1.01 0.908 1.05 0.516 LSAMP 1 0.074 0.90 0.528 1.10 0.565 1.00 0.970 LUM 34 0.000 0.91 0.023 0.79 0.000 0.85 0.000 LYVE1 4 0.054 0.85 0.110 0.91 0.342 0.88 0.073 LYZ 2 0.003 1.06 0.731 1.00 0.991 1.03 0.808 MAN1A1 5 0.001 1.18 0.083 1.07 0.485 1.12 0.093 MAN2A2 1 0.179 1.13 0.445 1.04 0.831 1.08 0.484 MASP1 17 0.000 0.83 0.000 0.87 0.002 0.85 0.000 MASP2 8 0.135 1.00 0.987 0.93 0.283 0.96 0.444 MB 1 0.005 0.87 0.465 0.78 0.210 0.82 0.157 MBL2 4 0.008 1.06 0.642 1.37 0.020 1.21 0.052 MCAM 1 0.013 0.70 0.109 0.77 0.231 0.73 0.049 MEGF8 2 0.217 1.01 0.955 1.00 0.995 1.00 0.965 MIF 0 — — — — — — — MINPP1 2 0.149 0.99 0.929 0.87 0.329 0.92 0.452 MMP2 3 0.000 0.62 0.000 0.67 0.000 0.64 0.000 MMP9 2 0.000 1.68 0.005 1.15 0.441 1.39 0.014 MMRN2 1 0.075 1.13 0.546 0.96 0.858 1.04 0.766 MRPS26 1 0.055 0.90 0.699 0.95 0.860 0.93 0.692 MSN 3 0.000 1.37 0.027 0.74 0.030 1.00 0.981 MST1 15 0.000 1.21 0.005 0.91 0.177 1.05 0.322 MTPN 1 0.005 1.58 0.285 0.46 0.067 0.85 0.625 NAGLU 3 0.005 1.12 0.358 0.86 0.217 0.98 0.829 NCAM1 2 0.096 0.87 0.341 0.98 0.911 0.92 0.455 NEO1 1 0.024 0.88 0.452 0.76 0.117 0.82 0.098 NID1 7 0.000 1.24 0.005 1.25 0.004 1.24 0.000 NRGN 1 0.013 1.02 0.954 0.56 0.042 0.75 0.181 NRP1 3 0.013 0.96 0.729 1.16 0.191 1.06 0.503 NUCB1 1 0.060 1.18 0.556 1.35 0.277 1.26 0.230 NUP210L 1 0.011 1.20 0.613 1.72 0.128 1.44 0.153 OAF 2 0.000 1.30 0.013 1.30 0.013 1.30 0.000 OLFM1 2 0.093 1.01 0.934 1.18 0.282 1.10 0.414 ORM1 10 0.000 1.95 0.000 1.75 0.000 1.85 0.000 ORM2 10 0.000 1.88 0.000 1.57 0.000 1.72 0.000 PAM 1 0.158 0.99 0.952 1.12 0.538 1.05 0.691 PCOLCE 4 0.000 0.87 0.152 0.83 0.051 0.85 0.018 PCSK9 3 0.011 0.93 0.613 0.90 0.426 0.91 0.357 PDIA3 2 0.021 1.26 0.061 1.12 0.372 1.19 0.050 PDLIM1 3 0.000 1.88 0.009 0.57 0.019 1.03 0.865 PEPD 9 0.000 0.71 0.000 0.65 0.000 0.68 0.000 PF4 11 0.000 0.92 0.235 0.95 0.408 0.94 0.165 PFN1 7 0.000 1.68 0.000 0.59 0.000 0.99 0.955 PGLYRP2 28 0.000 0.64 0.000 0.71 0.000 0.67 0.000 PI16 6 0.000 0.63 0.001 0.78 0.079 0.70 0.000 PIGR 1 0.047 1.35 0.220 1.18 0.507 1.26 0.189 PLEK 1 0.005 1.23 0.614 X 0.41 0.029 0.71 0.273 PLS1 1 0.031 1.34 0.130 1.19 0.364 1.26 0.084 PLTP 3 0.001 1.32 0.097 1.38 0.053 1.35 0.012 PLXNB1 2 0.011 1.33 0.028 1.16 0.242 1.24 0.018 PODXL 1 0.218 1.00 0.992 0.97 0.859 0.98 0.892 PON1 5 0.003 0.80 0.047 0.85 0.135 0.83 0.015 PON3 0 — — — — — — — POR 0 — — — — — — — POSTN 2 0.074 1.04 0.776 1.24 0.166 1.14 0.242 PPBP 23 0.000 1.11 0.073 1.25 0.000 1.17 0.000 PPIA 5 0.000 X 2.07 0.000 0.86 0.304 1.33 0.011 PPIB 1 0.027 1.34 0.157 1.05 0.815 1.18 0.244 PRAP1 1 0.017 1.11 0.694 0.93 0.780 1.01 0.935 PRDX2 6 0.000 X 2.04 0.000 1.47 0.011 1.73 0.000 PRDX6 1 0.028 1.69 0.048 1.32 0.293 1.50 0.031 PRG4 5 0.000 1.43 0.002 1.05 0.667 1.23 0.014 PROC 9 0.014 0.87 0.056 0.92 0.248 0.89 0.031 PROCR 4 0.071 1.05 0.678 0.92 0.473 0.98 0.831 PROS1 14 0.000 0.88 0.048 0.95 0.426 0.92 0.053 PROZ 12 0.000 0.78 0.006 0.96 0.662 0.86 0.026 PRSS1 1 0.203 1.04 0.882 1.08 0.741 1.06 0.731 PRSS3 1 0.202 0.98 0.939 1.15 0.544 1.06 0.705 PTGDS 2 0.189 1.01 0.964 1.11 0.570 1.06 0.664 PTPRG 1 0.000 0.52 0.003 0.57 0.013 0.55 0.000 PTPRJ 4 0.003 0.98 0.831 0.96 0.656 0.97 0.641 PTPRS 1 0.203 0.93 0.698 1.07 0.730 1.00 0.975 PVR 6 0.021 0.98 0.865 1.20 0.085 1.09 0.278 PVRL1 1 0.221 0.97 0.882 0.99 0.975 0.98 0.896 PZP 8 0.000 0.82 0.179 1.13 0.404 0.96 0.723 QSOX1 11 0.000 0.80 0.000 0.88 0.045 0.84 0.000 RBBP8 1 0.027 1.35 0.518 1.42 0.456 1.39 0.316 RNASE1 1 0.207 1.06 0.828 1.00 0.987 1.03 0.885 RTN4RL2 1 0.006 0.87 0.323 0.79 0.112 0.83 0.071 S100A12 2 0.002 1.19 0.451 0.63 0.046 0.87 0.405 S100A8 9 0.000 1.73 0.000 0.87 0.201 1.22 0.016 S100A9 18 0.000 X 2.01 0.000 1.05 0.534 1.45 0.000 SAA1 4 0.000 X 2.74 0.000 X 2.16 0.001 X 2.43 0.000 SAA4 14 0.000 1.11 0.163 0.75 0.000 0.91 0.105 SDPR 1 0.006 1.53 0.211 0.68 0.264 1.02 0.930 SELL 8 0.000 0.95 0.517 1.18 0.037 1.06 0.316 SEMA4B 1 0.014 0.99 0.952 0.76 0.196 0.87 0.341 SEPP1 8 0.001 0.89 0.178 0.89 0.174 0.89 0.057 SERPINA1 78 0.000 1.55 0.000 1.79 0.000 1.67 0.000 SERPINA10 16 0.000 1.01 0.910 0.99 0.865 1.00 0.969 SERPINA3 6 0.000 1.46 0.003 1.64 0.000 1.55 0.000 SERPINA4 22 0.000 X 0.49 0.000 0.62 0.000 0.55 0.000 SERPINA6 14 0.004 0.86 0.044 1.00 0.963 0.93 0.169 SERPINA7 37 0.000 0.87 0.001 0.94 0.168 0.90 0.001 SERPINB1 1 0.000 1.64 0.026 0.87 0.529 1.19 0.304 SERPINC1 1 0.007 1.50 0.127 1.56 0.095 1.53 0.022 SERPIND1 25 0.000 0.91 0.081 0.71 0.000 0.81 0.000 SERPINF1 41 0.000 0.92 0.027 0.87 0.000 0.90 0.000 SERPINF2 1 0.039 1.18 0.476 1.37 0.177 1.27 0.142 SERPING1 15 0.005 0.91 0.144 0.97 0.675 0.94 0.187 SH3BGRL 1 0.000 1.87 0.008 1.09 0.717 1.43 0.044 SH3BGRL3 3 0.000 1.86 0.001 0.85 0.414 1.26 0.113 SHBG 16 0.000 0.58 0.000 0.83 0.035 0.69 0.000 SLC3A2 2 0.000 0.55 0.000 0.73 0.047 0.63 0.000 SNCA 0 — — — — — — — SNED1 1 0.119 1.22 0.286 1.00 0.997 1.10 0.452 SOD3 5 0.004 0.93 0.507 0.86 0.154 0.89 0.146 SORL1 2 0.089 1.44 0.195 0.95 0.848 1.17 0.439 SOWAHC 0 — — — — — — — SPARC 11 0.000 1.12 0.139 1.15 0.055 1.13 0.019 SPARCL1 2 0.042 1.01 0.933 1.22 0.189 1.11 0.331 SPP2 2 0.000 X 0.45 0.000 X 0.48 0.000 X 0.47 0.000 SRGN 3 0.017 1.06 0.633 1.20 0.133 1.13 0.170 SSC5D 2 0.049 1.20 0.355 0.87 0.475 1.02 0.883 STXBP3 0 — — — — — — — TAGLN2 7 0.000 X 2.15 0.000 0.60 0.000 1.14 0.263 TF 8 0.001 0.80 0.030 0.79 0.025 0.79 0.002 TGFBI 14 0.000 0.75 0.000 0.96 0.593 0.85 0.002 THBS1 30 0.000 0.91 0.050 0.86 0.001 0.88 0.000 TIMP1 1 0.181 1.05 0.809 1.01 0.958 1.03 0.835 TKT 3 0.000 1.63 0.001 1.26 0.125 1.44 0.001 TLN1 11 0.000 1.34 0.001 0.79 0.006 1.02 0.707 TMSB4X 6 0.000 1.70 0.001 0.63 0.003 1.04 0.761 TNC 5 0.205 1.08 0.509 1.02 0.878 1.05 0.566 TNXB 19 0.000 0.82 0.000 0.94 0.185 0.88 0.000 TPI1 2 0.001 1.47 0.027 0.96 0.807 1.19 0.180 TPM3 3 0.000 1.43 0.025 0.69 0.019 0.99 0.942 TPM4 1 0.072 1.29 0.457 0.71 0.313 0.96 0.854 TREML1 3 0.000 1.98 0.000 1.12 0.491 1.49 0.002 TTR 4 0.208 1.00 0.977 0.97 0.816 0.98 0.854 TUBA4A 2 0.003 1.26 0.125 0.95 0.721 1.09 0.413 UMOD 1 0.066 1.24 0.151 1.21 0.215 1.22 0.054 VASN 7 0.072 0.98 0.723 0.97 0.640 0.97 0.562 VASP 1 0.003 1.19 0.472 0.66 0.077 0.88 0.488 VCAM1 12 0.007 1.12 0.111 1.15 0.040 1.13 0.010 VCL 5 0.008 1.19 0.111 0.97 0.740 1.07 0.378 VIM 2 0.219 1.04 0.879 1.02 0.928 1.03 0.863 VNN1 4 0.001 0.83 0.275 0.72 0.054 0.77 0.036 VTN 4 0.027 0.89 0.297 0.87 0.192 0.88 0.098 VWF 60 0.000 1.09 0.023 1.02 0.626 1.05 0.052 YWHAE 0 — — — — — — — YWHAG 0 — — — — — — — YWHAZ 0 — — — — — — — ZYX 3 0.000 X 2.16 0.006 0.59 0.061 1.13 0.569

TABLE 2C Marker Discovery *Differential expression (DE) thresholds: p-value <0.05|q-value <0.05|ANOVA DI >2 Asymptomatic Active TB vs Active TB vs (HIV−) and Asymptomatic (HIV+) Asymptomatic and LTBI (HIV−) and LTBI (HIV+) LTBI|HIV+/− ANOVA ANOVA ANOVA PROTEIN #PEPTIDES q-value DE DI p-value DE DI p-value DE DI p-value A1BG 3 0.031 0.90 0.259 1.09 0.349 0.99 0.877 A2M 119 0.000 0.96 0.062 0.85 0.000 0.91 0.000 ABI3BP 7 0.062 1.00 0.992 0.96 0.523 0.98 0.665 ACTN1 0 — — — — — — — ADAMTS13 5 0.000 0.75 0.000 0.91 0.125 0.82 0.000 ADAMTSL4 1 0.041 0.79 0.076 1.00 0.995 0.89 0.226 AFM 6 0.000 0.51 0.000 0.53 0.000 0.52 0.000 AGT 25 0.000 0.86 0.000 0.89 0.001 0.87 0.000 AHSG 2 0.062 1.25 0.056 1.19 0.155 1.22 0.023 ALB 12 0.020 1.06 0.297 1.08 0.189 1.07 0.110 ALCAM 5 0.140 1.07 0.302 1.06 0.382 1.07 0.195 ALDOA 6 0.016 1.15 0.068 1.03 0.738 1.09 0.139 ALDOB 6 0.000 0.75 0.003 0.69 0.000 0.72 0.000 AMBP 12 0.096 1.00 0.949 0.96 0.471 0.98 0.662 ANGPTL3 3 0.007 1.17 0.058 0.94 0.453 1.05 0.430 ANPEP 9 0.005 0.96 0.471 0.89 0.038 0.93 0.060 AOC3 3 0.087 1.14 0.163 1.10 0.328 1.12 0.106 APCS 5 0.000 1.64 0.000 1.27 0.009 1.45 0.000 APOA1 42 0.000 0.54 0.000 0.66 0.000 0.59 0.000 APOA2 6 0.000 0.61 0.000 0.66 0.000 0.63 0.000 APOA4 149 0.000 0.52 0.000 0.58 0.000 0.55 0.000 APOB 262 0.000 0.83 0.000 0.77 0.000 0.80 0.000 APOC1 7 0.000 0.58 0.000 X 0.49 0.000 0.53 0.000 APOC2 6 0.000 X 0.45 0.000 X 0.32 0.000 X 0.38 0.000 APOC3 12 0.000 X 0.48 0.000 X 0.34 0.000 X 0.40 0.000 APOC4 8 0.000 X 0.42 0.000 X 0.29 0.000 X 0.35 0.000 APOD 3 0.011 0.84 0.029 0.81 0.009 0.82 0.001 APOE 47 0.000 0.65 0.000 X 0.43 0.000 0.53 0.000 APOF 3 0.032 1.02 0.806 1.05 0.616 1.04 0.614 APOL1 9 0.066 1.12 0.109 1.13 0.097 1.12 0.027 APOM 3 0.000 0.71 0.003 0.64 0.000 0.68 0.000 APP 6 0.021 1.02 0.757 1.06 0.353 1.04 0.404 ARHGDIB 3 0.000 1.33 0.009 1.03 0.777 1.17 0.053 ARPC5 0 — — — — — — — ATP6AP1L 0 — — — — — — — ATRN 26 0.000 0.81 0.000 0.78 0.000 0.80 0.000 AXL 1 0.084 0.72 0.110 0.78 0.229 0.75 0.053 AZGP1 40 0.000 1.09 0.001 1.22 0.000 1.15 0.000 B2M 16 0.000 1.44 0.000 1.22 0.000 1.33 0.000 B4GALT1 1 0.161 1.23 0.211 1.15 0.413 1.19 0.149 BCHE 12 0.000 0.76 0.000 0.72 0.000 0.74 0.000 BLVRB 1 0.096 1.29 0.258 1.20 0.427 1.25 0.179 BST1 4 0.023 1.03 0.670 1.15 0.070 1.09 0.136 BTD 7 0.028 0.81 0.023 0.86 0.114 0.84 0.009 C1R 66 0.020 1.00 0.986 1.04 0.061 1.02 0.215 C1RL 21 0.047 1.02 0.659 1.04 0.312 1.03 0.327 C1S 57 0.003 0.95 0.007 0.98 0.440 0.96 0.017 C2 44 0.000 1.12 0.000 1.01 0.632 1.06 0.001 C3 3 0.054 1.24 0.075 1.11 0.373 1.17 0.069 C4BPA 3 0.003 1.27 0.005 1.13 0.155 1.20 0.004 C5 2 0.003 1.32 0.008 1.00 0.966 1.15 0.072 C6 0 — — — — — — — C9 0 — — — — — — — CA1 7 0.000 1.59 0.000 1.23 0.092 1.40 0.000 CA2 3 0.000 1.75 0.001 1.35 0.071 1.54 0.001 CACNA2D1 5 0.000 0.72 0.000 0.92 0.214 0.81 0.000 CALM1 0 — — — — — — — CALU 2 0.074 1.12 0.383 1.26 0.076 1.18 0.073 CAT 5 0.000 1.36 0.001 1.13 0.185 1.24 0.002 CCDC149 1 0.000 0.57 0.000 0.59 0.001 0.58 0.000 CD14 19 0.000 1.17 0.000 1.16 0.000 1.16 0.000 CD163 6 0.000 1.32 0.000 1.17 0.041 1.24 0.000 CD44 4 0.055 1.03 0.745 0.96 0.705 1.00 0.978 CD59 1 0.074 1.19 0.091 1.18 0.112 1.18 0.024 CD5L 14 0.000 1.17 0.017 1.89 0.000 1.48 0.000 CD84 1 0.006 1.24 0.268 0.89 0.543 1.05 0.721 CD93 3 0.074 0.87 0.120 0.90 0.215 0.88 0.058 CDH1 4 0.024 1.12 0.162 1.10 0.270 1.11 0.089 CDH13 4 0.000 0.65 0.000 0.82 0.026 0.73 0.000 CDH2 1 0.046 0.82 0.234 0.72 0.059 0.77 0.036 CDH5 9 0.003 0.98 0.697 1.04 0.355 1.01 0.729 CETP 1 0.085 0.74 0.123 0.77 0.185 0.75 0.048 CFB 0 — — — — — — — CFD 10 0.000 0.87 0.001 0.85 0.000 0.86 0.000 CFL1 0 — — — — — — — CFP 1 0.179 0.96 0.770 0.94 0.635 0.95 0.593 CHI3L1 1 0.000 X 2.21 0.000 1.82 0.001 X 2.01 0.000 CHL1 15 0.001 0.99 0.727 0.89 0.007 0.94 0.044 CKM 3 0.000 0.71 0.004 0.63 0.000 0.67 0.000 CLC 1 0.113 1.19 0.342 1.27 0.190 1.22 0.119 CLEC3B 25 0.000 0.70 0.000 0.73 0.000 0.72 0.000 CLIC1 0 — — — — — — — CLU 50 0.001 1.01 0.812 0.99 0.707 1.00 0.932 CNDP1 32 0.000 0.63 0.000 0.79 0.000 0.70 0.000 CNN2 1 0.000 1.35 0.234 0.80 0.369 1.04 0.826 CNTN1 7 0.000 0.77 0.000 0.95 0.443 0.86 0.001 COL18A1 2 0.134 0.86 0.297 0.86 0.293 0.86 0.150 COL6A1 3 0.089 0.91 0.313 0.91 0.325 0.91 0.176 COL6A3 10 0.000 0.82 0.000 0.93 0.068 0.87 0.000 COLEC10 2 0.007 0.83 0.024 0.81 0.012 0.82 0.001 COLEC11 6 0.001 0.85 0.003 0.86 0.006 0.86 0.000 COMP 5 0.000 0.79 0.000 0.66 0.000 0.72 0.000 CORO1A 2 0.000 1.72 0.000 1.13 0.401 1.40 0.002 CORO1B 1 0.206 1.05 0.825 1.02 0.919 1.04 0.819 COTL1 1 0.007 1.37 0.169 1.01 0.975 1.18 0.330 CP 3 0.000 1.75 0.000 1.15 0.228 1.43 0.000 CPB2 20 0.205 1.01 0.855 1.00 0.931 1.00 0.854 CPN1 21 0.140 1.01 0.874 1.00 0.911 1.00 0.972 CPN2 17 0.000 0.84 0.000 0.84 0.001 0.84 0.000 CPQ 1 0.005 0.86 0.344 0.64 0.005 0.75 0.016 CRP 3 0.000 X 4.43 0.000 X 2.66 0.000 X 3.45 0.000 CRTAC1 8 0.000 0.70 0.000 0.65 0.000 0.67 0.000 CSF1R 3 0.048 0.96 0.647 0.90 0.266 0.93 0.291 CST3 6 0.005 1.19 0.017 1.14 0.083 1.16 0.005 CTBS 9 0.000 0.77 0.000 0.70 0.000 0.74 0.000 CTSD 1 0.042 1.22 0.286 0.86 0.404 1.03 0.857 DAG1 3 0.057 1.00 0.974 1.06 0.454 1.03 0.634 DBH 7 0.020 0.80 0.023 0.95 0.613 0.87 0.058 DPEP2 1 0.113 0.90 0.552 1.11 0.543 1.00 0.995 DPP4 1 0.041 0.89 0.301 1.00 0.999 0.94 0.468 DSG2 1 0.066 0.86 0.149 1.00 0.969 0.92 0.305 ECM1 12 0.000 1.05 0.298 1.20 0.000 1.12 0.002 ENDOD1 1 0.147 0.81 0.215 0.92 0.598 0.86 0.218 ENG 1 0.085 1.39 0.124 1.12 0.600 1.25 0.153 ENO1 3 0.000 1.30 0.006 1.07 0.501 1.18 0.022 ENPP2 7 0.000 1.09 0.254 0.95 0.498 1.02 0.737 ERAP1 1 0.192 1.06 0.553 1.06 0.585 1.06 0.425 F10 19 0.000 1.03 0.336 1.06 0.044 1.04 0.045 F11 12 0.001 0.88 0.002 0.94 0.133 0.91 0.002 F12 23 0.000 0.61 0.000 0.70 0.000 0.65 0.000 F13A1 6 0.000 0.76 0.001 0.70 0.000 0.73 0.000 F13B 13 0.000 0.90 0.027 0.86 0.001 0.88 0.000 F2 16 0.089 1.06 0.218 1.04 0.385 1.05 0.152 F5 24 0.006 1.08 0.046 1.09 0.022 1.09 0.004 F7 5 0.000 0.79 0.001 0.73 0.000 0.76 0.000 F9 16 0.000 0.81 0.000 0.75 0.000 0.78 0.000 FAH 1 0.003 0.64 0.047 0.55 0.008 0.59 0.002 FAM3C 1 0.144 1.04 0.707 1.12 0.301 1.08 0.332 FBLN1 8 0.000 0.81 0.000 0.87 0.008 0.84 0.000 FBXO33 0 — — — — — — — FCGBP 12 0.000 1.19 0.000 1.00 0.934 1.10 0.007 FCGR3A 5 0.000 1.54 0.000 1.43 0.000 1.49 0.000 FCGR3B 4 0.000 1.25 0.034 1.17 0.135 1.21 0.014 FCN2 11 0.000 1.07 0.151 1.11 0.047 1.09 0.021 FCN3 13 0.172 0.94 0.287 0.99 0.884 0.97 0.404 FETUB 13 0.000 1.32 0.000 0.95 0.265 1.12 0.003 FGA 19 0.000 1.49 0.000 1.60 0.000 1.54 0.000 FGB 0 — — — — — — — FGFR1 1 0.132 0.82 0.244 0.93 0.689 0.87 0.274 FGG 0 — — — — — — — FKBP1A 1 0.039 1.26 0.167 1.04 0.822 1.15 0.265 FLNA 10 0.000 1.45 0.000 0.94 0.499 1.18 0.017 FLT4 1 0.203 1.06 0.673 0.99 0.922 1.02 0.815 FN1 3 0.022 1.18 0.122 1.01 0.904 1.10 0.254 FTL 2 0.002 1.34 0.122 1.43 0.057 1.38 0.019 FUCA1 1 0.138 1.29 0.314 1.03 0.901 1.16 0.427 FUCA2 1 0.015 1.29 0.093 0.90 0.486 1.08 0.506 GALNT2 1 0.089 1.10 0.527 1.27 0.125 1.18 0.140 GAPDH 2 0.003 0.98 0.888 0.76 0.053 0.86 0.170 GC 1 0.096 0.84 0.222 0.91 0.498 0.87 0.186 GGH 9 0.000 1.35 0.000 0.94 0.200 1.13 0.001 GK 0 — — — — — — — GNPTG 2 0.100 1.01 0.931 1.04 0.689 1.02 0.740 GOSR1 0 — — — — — — — GP1BA 9 0.000 1.09 0.078 1.12 0.021 1.11 0.006 GP5 6 0.006 0.94 0.372 1.06 0.367 1.00 0.987 GPLD1 18 0.000 0.75 0.000 0.69 0.000 0.72 0.000 GPR126 1 0.148 0.95 0.636 0.92 0.454 0.93 0.395 GPX3 16 0.000 1.02 0.563 1.16 0.000 1.09 0.006 GSN 58 0.000 0.62 0.000 0.66 0.000 0.64 0.000 GSTO1 1 0.001 1.52 0.001 1.14 0.318 1.32 0.006 GSTP1 0 — — — — — — — HABP2 7 0.042 0.97 0.670 0.91 0.110 0.94 0.174 HBA1 11 0.000 X 2.28 0.000 1.78 0.000 X 2.02 0.000 HBB 6 0.000 X 2.23 0.000 1.74 0.000 1.98 0.000 HEG1 1 0.208 0.93 0.527 1.00 0.968 0.96 0.633 HGFAC 16 0.004 0.86 0.005 0.93 0.204 0.89 0.006 HIST1H4A 5 0.000 1.74 0.000 1.10 0.338 1.39 0.000 HP 39 0.000 X 2.98 0.000 X 2.55 0.000 X 2.76 0.000 HPR 10 0.000 1.68 0.000 1.55 0.000 1.62 0.000 HPX 2 0.207 0.96 0.721 1.04 0.716 1.00 0.996 HRNR 7 0.000 1.04 0.700 1.37 0.003 1.19 0.026 HSP90B1 4 0.021 0.87 0.111 0.80 0.016 0.83 0.007 HSPA5 10 0.052 1.04 0.313 0.98 0.553 1.01 0.762 HSPA8 0 — — — — — — — HSPB1 0 — — — — — — — HSPG2 9 0.000 0.86 0.003 0.97 0.502 0.91 0.012 HYOU1 3 0.060 0.84 0.058 0.96 0.657 0.90 0.111 ICAM1 5 0.000 1.55 0.000 1.27 0.001 1.41 0.000 ICAM2 1 0.206 1.05 0.702 1.09 0.461 1.07 0.437 ICOSLG 1 0.050 0.89 0.234 0.95 0.588 0.91 0.226 IDH1 1 0.003 1.62 0.001 1.28 0.103 1.45 0.002 IGF1 2 0.002 0.71 0.005 0.94 0.586 0.81 0.026 IGF2 5 0.000 0.64 0.000 0.83 0.009 0.73 0.000 IGF2R 1 0.062 1.16 0.182 1.11 0.384 1.14 0.125 IGFALS 37 0.000 0.72 0.000 0.92 0.004 0.81 0.000 IGFBP1 1 0.154 0.75 0.227 0.81 0.364 0.78 0.140 IGFBP2 6 0.000 X 2.08 0.000 X 2.05 0.000 X 2.07 0.000 IGFBP3 13 0.000 0.70 0.000 0.98 0.703 0.82 0.000 IGFBP4 1 0.124 1.01 0.944 0.96 0.826 0.99 0.919 IGFBP5 3 0.000 0.75 0.000 0.99 0.890 0.86 0.013 IGFBP6 2 0.006 0.92 0.287 1.04 0.607 0.98 0.694 IGFBP7 1 0.181 0.92 0.452 1.02 0.892 0.96 0.660 IGLL5 19 0.000 1.62 0.000 1.76 0.000 1.69 0.000 IL1R2 1 0.030 0.90 0.307 0.86 0.150 0.88 0.090 IL1RAP 7 0.000 0.72 0.000 0.95 0.428 0.83 0.000 IL6ST 3 0.134 1.24 0.144 1.10 0.506 1.17 0.147 ISLR 3 0.013 0.86 0.054 0.90 0.180 0.88 0.027 ITGB1 1 0.083 0.83 0.188 0.77 0.075 0.80 0.034 ITIH1 2 0.161 1.13 0.314 1.12 0.343 1.12 0.178 ITIH2 3 0.079 0.85 0.077 0.94 0.508 0.90 0.099 ITIH3 17 0.000 1.78 0.000 1.50 0.000 1.64 0.000 ITIH4 59 0.000 1.33 0.000 1.30 0.000 1.31 0.000 KIT 2 0.000 0.63 0.000 0.69 0.004 0.66 0.000 KLKB1 14 0.000 0.85 0.000 0.85 0.000 0.85 0.000 KNG1 7 0.019 1.11 0.402 1.37 0.014 1.23 0.028 KRT1 30 0.000 0.96 0.447 1.08 0.170 1.02 0.698 KRT10 8 0.018 1.17 0.126 1.30 0.012 1.23 0.006 KRT14 3 0.198 0.93 0.481 0.97 0.793 0.95 0.507 KRT2 11 0.000 1.30 0.006 1.35 0.002 1.32 0.000 KRT5 1 0.088 1.39 0.184 1.49 0.107 1.44 0.043 KRT9 16 0.000 1.03 0.732 1.22 0.015 1.12 0.063 LAMB1 1 0.116 0.93 0.476 0.88 0.208 0.90 0.174 LAMP1 2 0.089 0.94 0.474 0.88 0.167 0.91 0.153 LAMP2 2 0.198 0.90 0.386 0.91 0.446 0.90 0.261 LASP1 1 0.034 1.13 0.559 0.91 0.635 1.01 0.929 LBP 1 0.000 1.81 0.000 1.61 0.001 1.71 0.000 LCAT 18 0.000 0.80 0.000 0.74 0.000 0.77 0.000 LCN2 2 0.082 1.15 0.311 1.05 0.735 1.10 0.349 LCP1 12 0.000 1.45 0.000 1.27 0.000 1.36 0.000 LDHB 3 0.126 1.08 0.405 1.04 0.646 1.06 0.378 LGALS3BP 28 0.000 1.08 0.066 0.78 0.000 0.92 0.011 LGALSL 2 0.000 1.48 0.004 0.92 0.530 1.17 0.140 LILRA1 1 0.062 0.92 0.790 0.60 0.087 0.75 0.188 LILRA3 1 0.039 1.27 0.307 0.79 0.319 1.01 0.967 LPA 16 0.000 0.93 0.309 1.03 0.681 0.98 0.668 LRG1 45 0.000 1.75 0.000 1.57 0.000 1.66 0.000 LRP1 4 0.192 1.04 0.572 1.02 0.731 1.03 0.535 LSAMP 1 0.074 0.89 0.287 1.09 0.458 0.98 0.811 LUM 34 0.000 0.84 0.000 0.81 0.000 0.83 0.000 LYVE1 4 0.054 0.89 0.094 0.95 0.475 0.92 0.103 LYZ 2 0.003 1.28 0.050 1.01 0.958 1.14 0.170 MAN1A1 5 0.001 1.23 0.002 1.04 0.585 1.13 0.014 MAN2A2 1 0.179 1.04 0.732 1.03 0.786 1.04 0.666 MASP1 17 0.000 0.83 0.000 0.85 0.000 0.84 0.000 MASP2 8 0.135 0.98 0.615 0.96 0.405 0.97 0.366 MB 1 0.005 0.73 0.027 0.75 0.045 0.74 0.004 MBL2 4 0.008 1.04 0.705 1.21 0.044 1.12 0.112 MCAM 1 0.013 0.66 0.007 0.79 0.127 0.72 0.005 MEGF8 2 0.217 0.97 0.791 1.01 0.938 0.99 0.893 MIF 0 — — — — — — — MINPP1 2 0.149 0.94 0.534 0.91 0.383 0.93 0.305 MMP2 3 0.000 0.61 0.000 0.66 0.000 0.63 0.000 MMP9 2 0.000 1.83 0.000 1.42 0.010 1.62 0.000 MMRN2 1 0.075 0.94 0.698 0.99 0.958 0.97 0.755 MRPS26 1 0.055 0.89 0.554 0.77 0.194 0.83 0.194 MSN 3 0.000 1.26 0.025 0.89 0.253 1.06 0.453 MST1 15 0.000 1.10 0.047 0.89 0.014 0.99 0.803 MTPN 1 0.005 1.22 0.523 0.66 0.190 0.90 0.673 NAGLU 3 0.005 1.08 0.356 0.85 0.058 0.96 0.545 NCAM1 2 0.096 0.85 0.130 0.98 0.883 0.91 0.252 NEO1 1 0.024 0.80 0.073 0.77 0.035 0.79 0.008 NID1 7 0.000 1.19 0.001 1.24 0.000 1.22 0.000 NRGN 1 0.013 1.02 0.936 0.72 0.123 0.86 0.336 NRP1 3 0.013 1.05 0.546 1.18 0.038 1.11 0.075 NUCB1 1 0.060 1.27 0.214 1.44 0.060 1.35 0.034 NUP210L 1 0.011 1.41 0.165 1.90 0.011 1.63 0.009 OAF 2 0.000 1.23 0.006 1.28 0.001 1.25 0.000 OLFM1 2 0.093 0.96 0.736 1.09 0.425 1.02 0.764 ORM1 10 0.000 X 2.08 0.000 1.67 0.000 1.87 0.000 ORM2 10 0.000 1.92 0.000 1.43 0.000 1.66 0.000 PAM 1 0.158 1.08 0.545 1.10 0.439 1.09 0.336 PCOLCE 4 0.000 0.80 0.001 0.83 0.008 0.81 0.000 PCSK9 3 0.011 0.84 0.081 0.83 0.065 0.84 0.016 PDIA3 2 0.021 1.22 0.021 1.16 0.087 1.19 0.006 PDLIM1 3 0.000 1.60 0.011 0.93 0.717 1.23 0.144 PEPD 9 0.000 0.72 0.000 0.69 0.000 0.71 0.000 PF4 11 0.000 0.89 0.018 1.04 0.405 0.96 0.284 PFN1 7 0.000 1.48 0.000 0.89 0.173 1.15 0.042 PGLYRP2 28 0.000 0.66 0.000 0.70 0.000 0.68 0.000 PI16 6 0.000 0.56 0.000 0.72 0.001 0.63 0.000 PIGR 1 0.047 1.37 0.060 1.07 0.678 1.22 0.118 PLEK 1 0.005 1.05 0.874 0.62 0.113 0.81 0.352 PLS1 1 0.031 1.36 0.019 1.22 0.135 1.29 0.009 PLTP 3 0.001 1.45 0.002 1.32 0.019 1.38 0.000 PLXNB1 2 0.011 1.22 0.031 1.20 0.052 1.21 0.005 PODXL 1 0.218 0.98 0.858 0.95 0.654 0.96 0.663 PON1 5 0.003 0.78 0.002 0.87 0.071 0.82 0.001 PON3 0 — — — — — — — POR 0 — — — — — — — POSTN 2 0.074 1.02 0.835 1.19 0.102 1.10 0.218 PPBP 23 0.000 1.07 0.083 1.22 0.000 1.14 0.000 PPIA 5 0.000 1.84 0.000 1.24 0.055 1.52 0.000 PPIB 1 0.027 1.32 0.053 1.20 0.208 1.26 0.029 PRAP1 1 0.017 0.87 0.470 0.79 0.227 0.83 0.182 PRDX2 6 0.000 1.72 0.000 1.31 0.014 1.50 0.000 PRDX6 1 0.028 1.50 0.028 1.30 0.157 1.40 0.014 PRG4 5 0.000 1.28 0.002 1.07 0.442 1.17 0.010 PROC 9 0.014 0.87 0.010 0.91 0.062 0.89 0.003 PROCR 4 0.071 0.95 0.571 0.92 0.306 0.93 0.283 PROS1 14 0.000 0.82 0.000 0.92 0.072 0.87 0.000 PROZ 12 0.000 0.83 0.003 0.87 0.030 0.85 0.000 PRSS1 1 0.203 1.05 0.744 1.13 0.439 1.09 0.446 PRSS3 1 0.202 1.00 0.982 1.13 0.452 1.06 0.597 PTGDS 2 0.189 1.03 0.817 1.13 0.340 1.08 0.421 PTPRG 1 0.000 0.56 0.000 0.60 0.001 0.58 0.000 PTPRJ 4 0.003 0.90 0.097 0.90 0.095 0.90 0.024 PTPRS 1 0.203 0.93 0.604 1.03 0.836 0.98 0.821 PVR 6 0.021 0.97 0.668 1.10 0.216 1.03 0.600 PVRL1 1 0.221 0.96 0.739 0.98 0.895 0.97 0.743 PZP 8 0.000 1.07 0.530 1.07 0.539 1.07 0.398 QSOX1 11 0.000 0.83 0.000 0.83 0.000 0.83 0.000 RBBP8 1 0.027 1.68 0.115 1.81 0.076 1.74 0.022 RNASE1 1 0.207 1.10 0.618 1.07 0.713 1.09 0.543 RTN4RL2 1 0.006 0.78 0.016 0.82 0.055 0.80 0.003 S100A12 2 0.002 1.20 0.271 0.78 0.133 0.97 0.817 S100A8 9 0.000 1.57 0.000 1.14 0.109 1.34 0.000 S100A9 18 0.000 1.93 0.000 1.39 0.000 1.64 0.000 SAA1 4 0.000 X 2.61 0.000 X 2.18 0.000 X 2.39 0.000 SAA4 14 0.000 0.96 0.408 0.73 0.000 0.84 0.000 SDPR 1 0.006 1.46 0.136 1.00 0.991 1.21 0.308 SELL 8 0.000 1.04 0.470 1.16 0.010 1.10 0.027 SEMA4B 1 0.014 0.86 0.290 0.72 0.029 0.79 0.030 SEPP1 8 0.001 0.84 0.004 0.86 0.014 0.85 0.000 SERPINA1 78 0.000 1.75 0.000 1.57 0.000 1.66 0.000 SERPINA10 16 0.000 0.98 0.591 0.87 0.002 0.92 0.016 SERPINA3 6 0.000 1.56 0.000 1.60 0.000 1.58 0.000 SERPINA4 22 0.000 0.52 0.000 0.60 0.000 0.56 0.000 SERPINA6 14 0.004 0.94 0.277 0.95 0.379 0.95 0.180 SERPINA7 37 0.000 0.91 0.002 0.85 0.000 0.88 0.000 SERPINB1 1 0.000 1.57 0.006 1.11 0.532 1.32 0.028 SERPINC1 1 0.007 1.65 0.007 1.53 0.022 1.59 0.001 SERPIND1 25 0.000 0.91 0.011 0.76 0.000 0.83 0.000 SERPINF1 41 0.000 0.82 0.000 0.83 0.000 0.82 0.000 SERPINF2 1 0.039 1.33 0.079 1.32 0.085 1.33 0.017 SERPING1 15 0.005 0.88 0.006 0.96 0.368 0.92 0.013 SH3BGRL 1 0.000 1.78 0.001 1.34 0.087 1.55 0.001 SH3BGRL3 3 0.000 1.71 0.000 1.19 0.221 1.44 0.001 SHBG 16 0.000 0.81 0.001 0.77 0.000 0.79 0.000 SLC3A2 2 0.000 0.56 0.000 0.66 0.000 0.61 0.000 SNCA 0 — — — — — — — SNED1 1 0.119 1.17 0.211 1.00 0.975 1.08 0.396 SOD3 5 0.004 0.93 0.371 0.81 0.005 0.87 0.014 SORL1 2 0.089 1.23 0.294 1.05 0.807 1.14 0.369 SOWAHC 0 — — — — — — — SPARC 11 0.000 1.07 0.217 1.25 0.000 1.15 0.000 SPARCL1 2 0.042 0.96 0.692 1.17 0.160 1.05 0.510 SPP2 2 0.000 0.53 0.000 0.51 0.000 0.52 0.000 SRGN 3 0.017 1.03 0.706 1.22 0.019 1.12 0.075 SSC5D 2 0.049 1.08 0.559 0.85 0.252 0.96 0.720 STXBP3 0 — — — — — — — TAGLN2 7 0.000 1.87 0.000 1.03 0.790 1.40 0.000 TF 8 0.001 0.82 0.006 0.87 0.066 0.84 0.002 TGFBI 14 0.000 0.81 0.000 0.96 0.392 0.88 0.001 THBS1 30 0.000 0.83 0.000 0.91 0.006 0.87 0.000 TIMP1 1 0.181 1.01 0.929 1.10 0.539 1.06 0.628 TKT 3 0.000 1.52 0.000 1.30 0.014 1.41 0.000 TLN1 11 0.000 1.25 0.000 0.98 0.728 1.11 0.029 TMSB4X 6 0.000 1.60 0.000 0.96 0.700 1.24 0.015 TNC 5 0.205 1.04 0.626 1.03 0.681 1.04 0.541 TNXB 19 0.000 0.82 0.000 0.89 0.001 0.85 0.000 TPI1 2 0.001 1.42 0.004 1.08 0.525 1.24 0.019 TPM3 3 0.000 1.33 0.017 0.93 0.563 1.12 0.222 TPM4 1 0.072 1.13 0.622 0.89 0.623 1.00 0.988 TREML1 3 0.000 1.65 0.000 1.42 0.006 1.53 0.000 TTR 4 0.208 0.96 0.651 0.99 0.879 0.97 0.678 TUBA4A 2 0.003 1.28 0.023 1.11 0.327 1.19 0.027 UMOD 1 0.066 1.20 0.078 1.18 0.111 1.19 0.021 VASN 7 0.072 0.93 0.161 0.96 0.380 0.95 0.120 VASP 1 0.003 1.17 0.374 0.89 0.520 1.03 0.852 VCAM1 12 0.007 1.11 0.037 1.08 0.108 1.09 0.012 VCL 5 0.008 1.14 0.085 1.08 0.322 1.11 0.065 VIM 2 0.219 0.99 0.938 0.99 0.939 0.99 0.915 VNN1 4 0.001 0.72 0.007 0.79 0.049 0.75 0.002 VTN 4 0.027 0.88 0.083 0.84 0.025 0.86 0.007 VWF 60 0.000 1.07 0.013 0.97 0.320 1.02 0.292 YWHAE 0 — — — — — — — YWHAG 0 — — — — — — — YWHAZ 0 — — — — — — — ZYX 3 0.000 1.83 0.004 1.01 0.971 1.37 0.051

TABLE 2D Marker Discovery Active TB vs Asymptomatic Active TB vs LTBI PROTEIN #PEPTIDES DE ANOVA DI p-value q-value DE ANOVA DI p-value q-value A1BG 4 X 0.46 0.000 0.000 0.55 0.000 0.000 A2M 33 1.96 0.000 0.000 1.75 0.000 0.000 ABI3BP 3 1.54 0.000 0.000 1.24 0.007 0.000 ACTN1 0 — — — — — — ADAMTS13 0 — — — — — — ADAMTSL4 0 — — — — — — AFM 0 — — — — — — AGT 18 X 2.59 0.000 0.000 X 2.28 0.000 0.000 AHSG 0 — — — — — — ALB 4 X 0.45 0.000 0.000 0.62 0.000 0.000 ALCAM 0 — — — — — — ALDOA 0 — — — — — — ALDOB 0 — — — — — — AMBP 1 X 3.98 0.000 0.000 X 2.74 0.000 0.000 ANGPTL3 0 — — — — — — ANPEP 2 1.74 0.000 0.000 1.59 0.002 0.000 AOC3 0 — — — — — — APCS 2 X 3.34 0.000 0.000 X 2.80 0.000 0.000 APOA1 38 X 0.50 0.000 0.000 0.60 0.000 0.000 APOA2 10 0.51 0.000 0.000 0.59 0.000 0.000 APOA4 58 1.80 0.000 0.000 1.78 0.000 0.000 APOB 90 1.32 0.000 0.000 1.21 0.000 0.000 APOC1 6 X 0.23 0.000 0.000 X 0.34 0.000 0.000 APOC2 11 0.55 0.000 0.000 0.69 0.000 0.000 APOC3 4 0.75 0.006 0.000 1.02 0.846 0.000 APOC4 0 — — — — — — APOD 0 — — — — — — APOE 22 X 0.47 0.000 0.000 0.57 0.000 0.000 APOF 4 0.71 0.006 0.000 0.69 0.003 0.000 APOL1 3 0.89 0.345 0.001 0.93 0.554 0.001 APOM 0 — — — — — — APP 1 1.26 0.264 0.001 1.31 0.194 0.001 ARHGDIB 0 — — — — — — ARPC5 0 — — — — — — ATP6AP1L 1 1.47 0.022 0.000 1.37 0.056 0.000 ATRN 4 X 2.46 0.000 0.000 1.98 0.000 0.000 AXL 0 — — — — — — AZGP1 17 1.67 0.000 0.000 1.38 0.000 0.000 B2M 4 1.58 0.001 0.000 1.51 0.003 0.000 B4GALT1 0 — — — — — — BCHE 0 — — — — — — BLVRB 0 — — — — — — BST1 0 — — — — — — BTD 2 X 2.42 0.000 0.000 1.88 0.000 0.000 C1R 16 1.92 0.000 0.000 1.90 0.000 0.000 C1RL 5 X 2.37 0.000 0.000 X 2.01 0.000 0.000 C1S 21 1.58 0.000 0.000 1.64 0.000 0.000 C2 21 X 2.61 0.000 0.000 X 2.25 0.000 0.000 C3 8 0.70 0.000 0.000 0.77 0.008 0.000 C4BPA 0 — — — — — — C5 4 X 0.41 0.000 0.000 X 0.46 0.000 0.000 C6 3 X 0.36 0.000 0.000 X 0.43 0.000 0.000 C9 3 0.80 0.036 0.000 0.76 0.009 0.000 CA1 8 X 3.28 0.000 0.000 X 2.67 0.000 0.000 CA2 4 X 2.15 0.000 0.000 1.89 0.000 0.000 CACNA2D1 1 1.80 0.001 0.000 1.46 0.036 0.000 CALM1 0 — — — — — — CALU 0 — — — — — — CAT 1 X 2.96 0.000 0.000 X 2.65 0.000 0.000 CCDC149 1 X 5.40 0.000 0.000 X 4.59 0.000 0.000 CD14 3 X 4.47 0.000 0.000 X 3.34 0.000 0.000 CD163 0 — — — — — — CD44 0 — — — — — — CD59 0 — — — — — — CD5L 1 X 2.17 0.000 0.000 1.54 0.040 0.000 CD84 0 — — — — — — CD93 0 — — — — — — CDH1 0 — — — — — — CDH13 3 1.35 0.003 0.000 1.33 0.005 0.000 CDH2 0 — — — — — — CDH5 4 1.29 0.005 0.000 1.27 0.009 0.000 CETP 0 — — — — — — CFB 6 0.61 0.000 0.000 0.69 0.000 0.000 CFD 3 1.77 0.000 0.000 1.49 0.000 0.000 CFL1 0 — — — — — — CFP 0 — — — — — — CHI3L1 0 — — — — — — CHL1 4 1.68 0.000 0.000 1.55 0.000 0.000 CKM 0 — — — — — — CLC 0 — — — — — — CLEC3B 7 1.58 0.000 0.000 1.10 0.395 0.000 CLIC1 0 — — — — — — CLU 36 1.03 0.433 0.000 1.00 0.905 0.000 CNDP1 4 1.57 0.000 0.000 1.37 0.002 0.000 CNN2 0 — — — — — — CNTN1 0 — — — — — — COL18A1 0 — — — — — — COL6A1 0 — — — — — — COL6A3 1 1.94 0.000 0.000 1.51 0.017 0.000 COLEC10 0 — — — — — — COLEC11 1 1.61 0.003 0.000 1.22 0.202 0.000 COMP 0 — — — — — — CORO1A 0 — — — — — — CORO1B 0 — — — — — — COTL1 0 — — — — — — CP 12 X 0.48 0.000 0.000 0.54 0.000 0.000 CPB2 9 X 2.61 0.000 0.000 X 2.17 0.000 0.000 CPN1 7 1.89 0.000 0.000 1.69 0.000 0.000 CPN2 8 X 3.02 0.000 0.000 X 2.27 0.000 0.000 CPQ 0 — — — — — — CRP 1 X 4.24 0.000 0.000 X 3.68 0.000 0.000 CRTAC1 0 — — — — — — CSF1R 0 — — — — — — CST3 2 1.00 0.991 0.000 0.89 0.433 0.000 CTBS 0 — — — — — — CTSD 0 — — — — — — DAG1 2 0.60 0.003 0.000 0.69 0.026 0.000 DBH 2 X 2.39 0.000 0.000 1.69 0.005 0.000 DPEP2 0 — — — — — — DPP4 0 — — — — — — DSG2 0 — — — — — — ECM1 0 — — — — — — ENDOD1 0 — — — — — — ENG 0 — — — — — — ENO1 0 — — — — — — ENPP2 0 — — — — — — ERAP1 0 — — — — — — F10 8 1.83 0.000 0.000 1.79 0.000 0.000 F11 2 1.33 0.025 0.000 1.25 0.076 0.000 F12 3 X 2.08 0.000 0.000 1.66 0.000 0.000 F13A1 0 — — — — — — F13B 1 X 2.08 0.000 0.000 1.78 0.000 0.000 F2 5 0.95 0.589 0.000 1.12 0.250 0.000 F5 9 1.89 0.000 0.000 1.64 0.000 0.000 F7 1 X 2.28 0.000 0.000 1.90 0.000 0.000 F9 5 X 2.86 0.000 0.000 X 2.48 0.000 0.000 FAH 0 — — — — — — FAM3C 0 — — — — — — FBLN1 2 1.83 0.000 0.000 1.51 0.000 0.000 FBXO33 0 — — — — — — FCGBP 0 — — — — — — FCGR3A 1 X 2.16 0.000 0.000 1.94 0.000 0.000 FCGR3B 1 1.01 0.872 0.017 0.99 0.950 0.017 FCN2 0 — — — — — — FCN3 2 X 3.03 0.000 0.000 X 2.12 0.000 0.000 FETUB 5 1.27 0.009 0.000 1.26 0.012 0.000 FGA 5 X 2.66 0.000 0.000 X 2.07 0.000 0.000 FGB 0 — — — — — — FGFR1 0 — — — — — — FGG 0 — — — — — — FKBP1A 1 X 2.36 0.000 0.000 X 2.29 0.000 0.000 FLNA 1 1.83 0.000 0.000 1.75 0.000 0.000 FLT4 0 — — — — — — FN1 0 — — — — — — FTL 2 X 2.98 0.000 0.000 X 2.45 0.000 0.000 FUCA1 0 — — — — — — FUCA2 0 — — — — — — GALNT2 0 — — — — — — GAPDH 0 — — — — — — GC 1 X 0.36 0.000 0.000 0.52 0.001 0.000 GGH 1 X 3.40 0.000 0.000 X 2.85 0.000 0.000 GK 0 — — — — — — GNPTG 0 — — — — — — GOSR1 1 0.98 0.914 0.001 0.91 0.618 0.001 GP1BA 4 X 3.61 0.000 0.000 X 2.81 0.000 0.000 GP5 0 — — — — — — GPLD1 6 X 2.34 0.000 0.000 1.87 0.000 0.000 GPR126 0 — — — — — — GPX3 5 1.57 0.000 0.000 1.22 0.026 0.000 GSN 36 1.06 0.123 0.000 0.94 0.070 0.000 GSTO1 0 — — — — — — GSTP1 1 1.92 0.000 0.000 1.85 0.000 0.000 HABP2 0 — — — — — — HBA1 4 X 2.27 0.000 0.000 X 2.26 0.000 0.000 HBB 5 X 3.97 0.000 0.000 X 3.12 0.000 0.000 HEG1 0 — — — — — — HGFAC 2 X 2.53 0.000 0.000 1.82 0.000 0.000 HIST1H4A 1 1.27 0.279 0.000 1.13 0.575 0.000 HP 10 1.82 0.000 0.000 1.58 0.000 0.000 HPR 1 X 2.85 0.000 0.000 1.97 0.001 0.000 HPX 1 X 4.66 0.000 0.000 X 2.63 0.000 0.000 HRNR 0 — — — — — — HSP90B1 0 — — — — — — HSPA5 1 1.05 0.624 0.005 1.01 0.921 0.005 HSPA8 0 — — — — — — HSPB1 0 — — — — — — HSPG2 1 1.24 0.308 0.008 1.20 0.378 0.008 HYOU1 0 — — — — — — ICAM1 1 X 2.36 0.000 0.000 1.98 0.000 0.000 ICAM2 1 1.87 0.000 0.000 1.55 0.005 0.000 ICOSLG 0 — — — — — — IDH1 0 — — — — — — IGF1 0 — — — — — — IGF2 0 — — — — — — IGF2R 0 — — — — — — IGFALS 15 1.92 0.000 0.000 1.66 0.000 0.000 IGFBP1 0 — — — — — — IGFBP2 0 — — — — — — IGFBP3 3 0.95 0.618 0.005 0.91 0.391 0.005 IGFBP4 0 — — — — — — IGFBP5 0 — — — — — — IGFBP6 0 — — — — — — IGFBP7 0 — — — — — — IGLL5 1 X 3.82 0.000 0.000 X 2.27 0.000 0.000 IL1R2 0 — — — — — — IL1RAP 0 — — — — — — IL6ST 0 — — — — — — ISLR 0 — — — — — — ITGB1 0 — — — — — — ITIH1 7 0.55 0.000 0.000 0.59 0.000 0.000 ITIH2 22 0.54 0.000 0.000 0.59 0.000 0.000 ITIH3 20 1.09 0.050 0.000 1.06 0.170 0.000 ITIH4 18 X 3.74 0.000 0.000 X 2.91 0.000 0.000 KIT 0 — — — — — — KLKB1 2 0.70 0.003 0.000 0.66 0.000 0.000 KNG1 7 0.66 0.000 0.000 0.67 0.000 0.000 KRT1 2 X 2.48 0.000 0.000 X 2.35 0.000 0.000 KRT10 2 X 2.26 0.000 0.000 X 2.17 0.000 0.000 KRT14 0 — — — — — — KRT2 1 X 2.31 0.000 0.000 X 2.20 0.000 0.000 KRT5 0 — — — — — — KRT9 2 1.32 0.037 0.000 1.36 0.021 0.000 LAMB1 0 — — — — — — LAMP1 1 0.55 0.012 0.000 0.60 0.029 0.000 LAMP2 0 — — — — — — LASP1 0 — — — — — — LBP 0 — — — — — — LCAT 6 1.84 0.000 0.000 1.65 0.000 0.000 LCN2 0 — — — — — — LCP1 2 1.49 0.001 0.000 1.36 0.007 0.000 LDHB 0 — — — — — — LGALS3BP 10 X 2.05 0.000 0.000 1.72 0.000 0.000 LGALSL 0 — — — — — — LILRA1 0 — — — — — — LILRA3 0 — — — — — — LPA 0 — — — — — — LRG1 31 X 3.04 0.000 0.000 X 2.68 0.000 0.000 LRP1 0 — — — — — — LSAMP 0 — — — — — — LUM 24 X 2.08 0.000 0.000 1.79 0.000 0.000 LYVE1 1 X 2.12 0.000 0.000 1.73 0.001 0.000 LYZ 0 — — — — — — MAN1A1 0 — — — — — — MAN2A2 0 — — — — — — MASP1 1 X 2.33 0.000 0.000 1.94 0.000 0.000 MASP2 2 1.58 0.000 0.000 1.47 0.000 0.000 MB 0 — — — — — — MBL2 1 X 3.41 0.000 0.000 X 2.68 0.000 0.000 MCAM 3 1.11 0.277 0.000 1.05 0.635 0.000 MEGF8 0 — — — — — — MIF 0 — — — — — — MINPP1 0 — — — — — — MMP2 1 1.79 0.000 0.000 1.49 0.006 0.000 MMP9 0 — — — — — — MMRN2 0 — — — — — — MRPS26 0 — — — — — — MSN 0 — — — — — — MST1 1 X 3.46 0.000 0.000 X 2.64 0.000 0.000 MTPN 0 — — — — — — NAGLU 0 — — — — — — NCAM1 0 — — — — — — NEO1 0 — — — — — — NID1 0 — — — — — — NRGN 0 — — — — — — NRP1 1 X 2.12 0.000 0.000 1.96 0.000 0.000 NUCB1 0 — — — — — — NUP210L 0 — — — — — — OAF 0 — — — — — — OLFM1 0 — — — — — — ORM1 1 1.55 0.031 0.000 1.55 0.030 0.000 ORM2 1 1.27 0.156 0.000 1.25 0.182 0.000 PAM 0 — — — — — — PCOLCE 1 1.87 0.000 0.000 1.43 0.024 0.000 PCSK9 0 — — — — — — PDIA3 0 — — — — — — PDLIM1 1 X 3.90 0.000 0.000 X 4.46 0.000 0.000 PEPD 0 — — — — — — PF4 0 — — — — — — PFN1 3 X 2.98 0.000 0.000 X 2.88 0.000 0.000 PGLYRP2 4 1.43 0.001 0.000 1.19 0.108 0.000 PI16 5 1.65 0.000 0.000 1.34 0.001 0.000 PIGR 0 — — — — — — PLEK 0 — — — — — — PLS1 0 — — — — — — PLTP 0 — — — — — — PLXNB1 0 — — — — — — PODXL 0 — — — — — — PON1 10 0.54 0.000 0.000 0.56 0.000 0.000 PON3 1 X 0.28 0.000 0.000 X 0.29 0.000 0.000 POR 1 0.96 0.901 0.021 1.05 0.875 0.021 POSTN 1 1.95 0.011 0.000 1.54 0.097 0.000 PPBP 6 1.98 0.000 0.000 1.59 0.000 0.000 PPIA 2 X 2.41 0.000 0.000 X 2.43 0.000 0.000 PPIB 0 — — — — — — PRAP1 0 — — — — — — PRDX2 4 X 3.13 0.000 0.000 X 2.65 0.000 0.000 PRDX6 1 X 2.41 0.000 0.000 X 2.12 0.000 0.000 PRG4 1 1.30 0.061 0.000 1.13 0.368 0.000 PROC 4 1.72 0.000 0.000 1.51 0.001 0.000 PROCR 1 X 2.58 0.000 0.000 X 2.01 0.003 0.000 PROS1 4 X 2.06 0.000 0.000 1.93 0.000 0.000 PROZ 3 X 2.11 0.000 0.000 1.63 0.000 0.000 PRSS1 0 — — — — — — PRSS3 1 X 2.21 0.000 0.000 1.73 0.000 0.000 PTGDS 1 1.63 0.005 0.000 1.32 0.111 0.000 PTPRG 0 — — — — — — PTPRJ 1 1.29 0.096 0.000 1.18 0.288 0.000 PTPRS 0 — — — — — — PVR 2 X 2.42 0.000 0.000 1.97 0.000 0.000 PVRL1 0 — — — — — — PZP 5 1.93 0.000 0.000 1.73 0.000 0.000 QSOX1 2 X 4.42 0.000 0.000 X 3.54 0.000 0.000 RBBP8 0 — — — — — — RNASE1 0 — — — — — — RTN4RL2 0 — — — — — — S100A12 0 — — — — — — S100A8 5 1.27 0.116 0.000 1.24 0.151 0.000 S100A9 8 X 4.00 0.000 0.000 X 3.40 0.000 0.000 SAA1 1 X 3.25 0.000 0.000 X 3.46 0.000 0.000 SAA4 3 0.58 0.001 0.000 0.62 0.002 0.000 SDPR 0 — — — — — — SELL 2 X 2.26 0.000 0.000 1.81 0.000 0.000 SEMA4B 0 — — — — — — SEPP1 3 1.36 0.011 0.000 1.14 0.256 0.000 SERPINA1 43 1.24 0.000 0.000 1.35 0.000 0.000 SERPINA10 1 1.80 0.000 0.000 1.61 0.000 0.000 SERPINA3 3 0.87 0.386 0.012 0.94 0.715 0.012 SERPINA4 7 X 2.45 0.000 0.000 1.87 0.000 0.000 SERPINA6 7 X 2.58 0.000 0.000 1.96 0.000 0.000 SERPINA7 17 X 2.72 0.000 0.000 X 2.18 0.000 0.000 SERPINB1 0 — — — — — — SERPINC1 2 0.66 0.000 0.000 0.76 0.011 0.000 SERPIND1 11 X 2.18 0.000 0.000 1.76 0.000 0.000 SERPINF1 25 X 2.26 0.000 0.000 1.84 0.000 0.000 SERPINF2 0 — — — — — — SERPING1 3 X 3.44 0.000 0.000 X 2.66 0.000 0.000 SH3BGRL 0 — — — — — — SH3BGRL3 3 X 2.53 0.000 0.000 X 2.50 0.000 0.000 SHBG 2 1.86 0.001 0.000 1.62 0.011 0.000 SLC3A2 0 — — — — — — SNCA 0 — — — — — — SNED1 0 — — — — — — SOD3 1 1.52 0.013 0.000 1.47 0.021 0.000 SORL1 0 — — — — — — SOWAHC 1 1.87 0.060 0.000 1.89 0.054 0.000 SPARC 3 1.89 0.000 0.000 1.68 0.000 0.000 SPARCL1 0 — — — — — — SPP2 0 — — — — — — SRGN 0 — — — — — — SSC5D 0 — — — — — — STXBP3 0 — — — — — — TAGLN2 1 X 2.40 0.001 0.000 X 2.76 0.000 0.000 TF 0 — — — — — — TGFBI 6 X 2.18 0.000 0.000 1.83 0.000 0.000 THBS1 7 1.67 0.000 0.000 1.58 0.000 0.000 TIMP1 0 — — — — — — TKT 1 0.64 0.003 0.000 0.68 0.011 0.000 TLN1 0 — — — — — — TMSB4X 1 1.38 0.001 0.000 1.29 0.011 0.000 TNC 2 X 2.25 0.000 0.000 1.93 0.000 0.000 TNXB 7 1.09 0.305 0.001 1.01 0.905 0.001 TPI1 1 X 2.31 0.000 0.000 1.98 0.000 0.000 TPM3 0 — — — — — — TPM4 0 — — — — — — TREML1 0 — — — — — — TTR 19 X 0.43 0.000 0.000 X 0.49 0.000 0.000 TUBA4A 0 — — — — — — UMOD 1 0.76 0.062 0.000 0.79 0.101 0.000 VASN 5 X 2.54 0.000 0.000 X 2.03 0.000 0.000 VASP 0 — — — — — — VCAM1 1 X 4.22 0.000 0.000 X 2.72 0.000 0.000 VCL 1 X 2.04 0.000 0.000 X 2.07 0.000 0.000 VIM 0 — — — — — — VNN1 0 — — — — — — VTN 0 — — — — — — VWF 8 X 2.85 0.000 0.000 X 2.35 0.000 0.000 YWHAE 0 — — — — — — YWHAG 0 — — — — — — YWHAZ 0 — — — — — — ZYX 0 — — — — — — *Differential expression (DE) thresholds: p-value <0.05|q-value <0.05|ANOVA DI >2

TABLE 2E Marker Discovery Active TB vs (Asymptomatic and LTBI) Active TB vs Extrapulmonary PROTEIN #PEPTIDES DE ANOVA DI p-value q-value DE ANOVA DI p-value q-value A1BG 4 0.50 0.000 0.000 0.81 0.036 0.000 A2M 33 1.85 0.000 0.000 1.70 0.000 0.000 ABI3BP 3 1.38 0.000 0.000 0.88 0.122 0.000 ACTN1 0 — — — — — — ADAMTS13 0 — — — — — — ADAMTSL4 0 — — — — — — AFM 0 — — — — — — AGT 18 X 2.43 0.000 0.000 X 2.02 0.000 0.000 AHSG 0 — — — — — — ALB 4 0.53 0.000 0.000 0.73 0.002 0.000 ALCAM 0 — — — — — — ALDOA 0 — — — — — — ALDOB 0 — — — — — — AMBP 1 X 3.29 0.000 0.000 1.70 0.025 0.000 ANGPTL3 0 — — — — — — ANPEP 2 1.66 0.000 0.000 1.21 0.216 0.000 AOC3 0 — — — — — — APCS 2 X 3.05 0.000 0.000 1.34 0.015 0.000 APOA1 38 0.55 0.000 0.000 0.79 0.000 0.000 APOA2 10 0.55 0.000 0.000 0.91 0.290 0.000 APOA4 58 1.79 0.000 0.000 X 2.15 0.000 0.000 APOB 90 1.26 0.000 0.000 X 2.89 0.000 0.000 APOC1 6 X 0.28 0.000 0.000 X 0.31 0.000 0.000 APOC2 11 0.62 0.000 0.000 0.54 0.000 0.000 APOC3 4 0.88 0.119 0.000 1.57 0.000 0.000 APOC4 0 — — — — — — APOD 0 — — — — — — APOE 22 0.51 0.000 0.000 0.81 0.000 0.000 APOF 4 0.70 0.000 0.000 X 0.25 0.000 0.000 APOL1 3 0.91 0.341 0.000 0.76 0.026 0.001 APOM 0 — — — — — — APP 1 1.28 0.131 0.001 0.91 0.649 0.001 ARHGDIB 0 — — — — — — ARPC5 0 — — — — — — ATP6AP1L 1 1.42 0.009 0.000 1.01 0.938 0.000 ATRN 4 X 2.20 0.000 0.000 1.72 0.000 0.000 AXL 0 — — — — — — AZGP1 17 1.51 0.000 0.000 0.85 0.003 0.000 B2M 4 1.54 0.000 0.000 1.23 0.149 0.000 B4GALT1 0 — — — — — — BCHE 0 — — — — — — BLVRB 0 — — — — — — BST1 0 — — — — — — BTD 2 X 2.13 0.000 0.000 1.69 0.000 0.000 C1R 16 1.91 0.000 0.000 X 3.17 0.000 0.000 C1RL 5 X 2.18 0.000 0.000 X 2.06 0.000 0.000 C1S 21 1.61 0.000 0.000 X 2.09 0.000 0.000 C2 21 X 2.42 0.000 0.000 1.29 0.000 0.000 C3 8 0.73 0.000 0.000 1.08 0.427 0.000 C4BPA 0 — — — — — — C5 4 X 0.44 0.000 0.000 1.05 0.652 0.000 C6 3 X 0.39 0.000 0.000 0.94 0.567 0.000 C9 3 0.78 0.003 0.000 1.19 0.105 0.000 CA1 8 X 2.95 0.000 0.000 1.09 0.383 0.000 CA2 4 X 2.01 0.000 0.000 0.91 0.444 0.000 CACNA2D1 1 1.62 0.001 0.000 1.41 0.068 0.000 CALM1 0 — — — — — — CALU 0 — — — — — — CAT 1 X 2.80 0.000 0.000 1.40 0.103 0.000 CCDC149 1 X 4.97 0.000 0.000 X 4.81 0.000 0.000 CD14 3 X 3.85 0.000 0.000 1.43 0.003 0.000 CD163 0 — — — — — — CD44 0 — — — — — — CD59 0 — — — — — — CD5L 1 1.82 0.000 0.000 1.89 0.003 0.000 CD84 0 — — — — — — CD93 0 — — — — — — CDH1 0 — — — — — — CDH13 3 1.34 0.000 0.000 1.18 0.119 0.000 CDH2 0 — — — — — — CDH5 4 1.28 0.001 0.000 1.03 0.765 0.000 CETP 0 — — — — — — CFB 6 0.65 0.000 0.000 0.96 0.611 0.000 CFD 3 1.62 0.000 0.000 0.82 0.068 0.000 CFL1 0 — — — — — — CFP 0 — — — — — — CHI3L1 0 — — — — — — CHL1 4 1.62 0.000 0.000 1.55 0.000 0.000 CKM 0 — — — — — — CLC 0 — — — — — — CLEC3B 7 1.31 0.003 0.000 1.28 0.031 0.000 CLIC1 0 — — — — — — CLU 36 1.01 0.686 0.000 1.66 0.000 0.000 CNDP1 4 1.46 0.000 0.000 X 2.45 0.000 0.000 CNN2 0 — — — — — — CNTN1 0 — — — — — — COL18A1 0 — — — — — — COL6A1 0 — — — — — — COL6A3 1 1.71 0.000 0.000 0.84 0.326 0.000 COLEC10 0 — — — — — — COLEC11 1 1.40 0.009 0.000 1.56 0.007 0.000 COMP 0 — — — — — — CORO1A 0 — — — — — — CORO1B 0 — — — — — — COTL1 0 — — — — — — CP 12 0.51 0.000 0.000 0.82 0.005 0.000 CPB2 9 X 2.38 0.000 0.000 1.62 0.000 0.000 CPN1 7 1.78 0.000 0.000 1.23 0.019 0.000 CPN2 8 X 2.61 0.000 0.000 1.73 0.000 0.000 CPQ 0 — — — — — — CRP 1 X 3.94 0.000 0.000 1.00 0.997 0.000 CRTAC1 0 — — — — — — CSF1R 0 — — — — — — CST3 2 0.94 0.625 0.000 X 0.48 0.000 0.000 CTBS 0 — — — — — — CTSD 0 — — — — — — DAG1 2 0.65 0.001 0.000 0.86 0.398 0.000 DBH 2 2.00 0.000 0.000 1.32 0.146 0.000 DPEP2 0 — — — — — — DPP4 0 — — — — — — DSG2 0 — — — — — — ECM1 0 — — — — — — ENDOD1 0 — — — — — — ENG 0 — — — — — — ENO1 0 — — — — — — ENPP2 0 — — — — — — ERAP1 0 — — — — — — F10 8 1.81 0.000 0.000 1.16 0.033 0.000 F11 2 1.28 0.012 0.000 1.11 0.433 0.000 F12 3 1.85 0.000 0.000 1.46 0.008 0.000 F13A1 0 — — — — — — F13B 1 1.92 0.000 0.000 1.64 0.001 0.000 F2 5 1.03 0.693 0.000 X 2.59 0.000 0.000 F5 9 1.76 0.000 0.000 1.58 0.000 0.000 F7 1 X 2.08 0.000 0.000 X 2.68 0.000 0.000 F9 5 X 2.66 0.000 0.000 X 2.15 0.000 0.000 FAH 0 — — — — — — FAM3C 0 — — — — — — FBLN1 2 1.66 0.000 0.000 1.22 0.100 0.000 FBXO33 0 — — — — — — FCGBP 0 — — — — — — FCGR3A 1 X 2.05 0.000 0.000 0.71 0.054 0.000 FCGR3B 1 1.00 0.953 0.019 0.94 0.507 0.017 FCN2 0 — — — — — — FCN3 2 X 2.53 0.000 0.000 1.93 0.000 0.000 FETUB 5 1.27 0.001 0.000 1.19 0.070 0.000 FGA 5 X 2.34 0.000 0.000 0.86 0.327 0.000 FGB 0 — — — — — — FGFR1 0 — — — — — — FGG 0 — — — — — — FKBP1A 1 X 2.33 0.000 0.000 1.36 0.106 0.000 FLNA 1 1.79 0.000 0.000 1.78 0.000 0.000 FLT4 0 — — — — — — FN1 0 — — — — — — FTL 2 X 2.70 0.000 0.000 X 0.39 0.000 0.000 FUCA1 0 — — — — — — FUCA2 0 — — — — — — GALNT2 0 — — — — — — GAPDH 0 — — — — — — GC 1 X 0.43 0.000 0.000 1.09 0.673 0.000 GGH 1 X 3.11 0.000 0.000 0.95 0.776 0.000 GK 0 — — — — — — GNPTG 0 — — — — — — GOSR1 1 0.94 0.703 0.000 1.38 0.102 0.001 GP1BA 4 X 3.17 0.000 0.000 1.50 0.000 0.000 GP5 0 — — — — — — GPLD1 6 X 2.09 0.000 0.000 X 2.35 0.000 0.000 GPR126 0 — — — — — — GPX3 5 1.38 0.000 0.000 0.91 0.298 0.000 GSN 36 0.99 0.840 0.000 1.28 0.000 0.000 GSTO1 0 — — — — — — GSTP1 1 1.89 0.000 0.000 1.12 0.519 0.000 HABP2 0 — — — — — — HBA1 4 X 2.27 0.000 0.000 1.24 0.172 0.000 HBB 5 X 3.51 0.000 0.000 1.29 0.062 0.000 HEG1 0 — — — — — — HGFAC 2 X 2.14 0.000 0.000 X 2.54 0.000 0.000 HIST1H4A 1 1.20 0.309 0.000 0.51 0.003 0.000 HP 10 1.69 0.000 0.000 0.74 0.001 0.000 HPR 1 X 2.36 0.000 0.000 1.41 0.100 0.000 HPX 1 X 3.48 0.000 0.000 1.16 0.504 0.000 HRNR 0 — — — — — — HSP90B1 0 — — — — — — HSPA5 1 1.03 0.716 0.005 0.89 0.311 0.005 HSPA8 0 — — — — — — HSPB1 0 — — — — — — HSPG2 1 1.22 0.236 0.006 0.98 0.911 0.008 HYOU1 0 — — — — — — ICAM1 1 X 2.16 0.000 0.000 1.05 0.736 0.000 ICAM2 1 1.70 0.000 0.000 0.89 0.450 0.000 ICOSLG 0 — — — — — — IDH1 0 — — — — — — IGF1 0 — — — — — — IGF2 0 — — — — — — IGF2R 0 — — — — — — IGFALS 15 1.78 0.000 0.000 1.51 0.000 0.000 IGFBP1 0 — — — — — — IGFBP2 0 — — — — — — IGFBP3 3 0.93 0.396 0.004 1.07 0.535 0.005 IGFBP4 0 — — — — — — IGFBP5 0 — — — — — — IGFBP6 0 — — — — — — IGFBP7 0 — — — — — — IGLL5 1 X 2.93 0.000 0.000 1.50 0.087 0.000 IL1R2 0 — — — — — — IL1RAP 0 — — — — — — IL6ST 0 — — — — — — ISLR 0 — — — — — — ITGB1 0 — — — — — — ITIH1 7 0.57 0.000 0.000 0.67 0.000 0.000 ITIH2 22 0.56 0.000 0.000 0.79 0.000 0.000 ITIH3 20 1.08 0.039 0.000 0.54 0.000 0.000 ITIH4 18 X 3.29 0.000 0.000 X 2.48 0.000 0.000 KIT 0 — — — — — — KLKB1 2 0.68 0.000 0.000 0.95 0.687 0.000 KNG1 7 0.66 0.000 0.000 1.08 0.451 0.000 KRT1 2 X 2.41 0.000 0.000 1.40 0.073 0.000 KRT10 2 X 2.21 0.000 0.000 1.14 0.432 0.000 KRT14 0 — — — — — — KRT2 1 X 2.25 0.000 0.000 1.46 0.085 0.000 KRT5 0 — — — — — — KRT9 2 1.34 0.006 0.000 1.13 0.386 0.000 LAMB1 0 — — — — — — LAMP1 1 0.58 0.004 0.000 X 0.28 0.000 0.000 LAMP2 0 — — — — — — LASP1 0 — — — — — — LBP 0 — — — — — — LCAT 6 1.74 0.000 0.000 1.20 0.019 0.000 LCN2 0 — — — — — — LCP1 2 1.42 0.000 0.000 0.77 0.028 0.000 LDHB 0 — — — — — — LGALS3BP 10 1.87 0.000 0.000 1.13 0.075 0.000 LGALSL 0 — — — — — — LILRA1 0 — — — — — — LILRA3 0 — — — — — — LPA 0 — — — — — — LRG1 31 X 2.85 0.000 0.000 0.81 0.000 0.000 LRP1 0 — — — — — — LSAMP 0 — — — — — — LUM 24 1.92 0.000 0.000 1.38 0.000 0.000 LYVE1 1 1.91 0.000 0.000 1.49 0.018 0.000 LYZ 0 — — — — — — MAN1A1 0 — — — — — — MAN2A2 0 — — — — — — MASP1 1 X 2.12 0.000 0.000 1.81 0.000 0.000 MASP2 2 1.52 0.000 0.000 1.33 0.005 0.000 MB 0 — — — — — — MBL2 1 X 3.02 0.000 0.000 X 2.60 0.000 0.000 MCAM 3 1.08 0.335 0.000 1.27 0.018 0.000 MEGF8 0 — — — — — — MIF 0 — — — — — — MINPP1 0 — — — — — — MMP2 1 1.63 0.000 0.000 0.95 0.749 0.000 MMP9 0 — — — — — — MMRN2 0 — — — — — — MRPS26 0 — — — — — — MSN 0 — — — — — — MST1 1 X 3.01 0.000 0.000 X 2.64 0.000 0.000 MTPN 0 — — — — — — NAGLU 0 — — — — — — NCAM1 0 — — — — — — NEO1 0 — — — — — — NID1 0 — — — — — — NRGN 0 — — — — — — NRP1 1 X 2.04 0.000 0.000 1.10 0.517 0.000 NUCB1 0 — — — — — — NUP210L 0 — — — — — — OAF 0 — — — — — — OLFM1 0 — — — — — — ORM1 1 1.55 0.007 0.000 0.60 0.016 0.000 ORM2 1 1.26 0.086 0.000 0.85 0.367 0.000 PAM 0 — — — — — — PCOLCE 1 1.63 0.000 0.000 0.78 0.127 0.000 PCSK9 0 — — — — — — PDIA3 0 — — — — — — PDLIM1 1 X 4.18 0.000 0.000 X 4.55 0.000 0.000 PEPD 0 — — — — — — PF4 0 — — — — — — PFN1 3 X 2.93 0.000 0.000 X 2.19 0.000 0.000 PGLYRP2 4 1.30 0.002 0.000 1.96 0.000 0.000 PI16 5 1.48 0.000 0.000 1.68 0.000 0.000 PIGR 0 — — — — — — PLEK 0 — — — — — — PLS1 0 — — — — — — PLTP 0 — — — — — — PLXNB1 0 — — — — — — PODXL 0 — — — — — — PON1 10 0.55 0.000 0.000 0.78 0.001 0.000 PON3 1 X 0.29 0.000 0.000 0.71 0.115 0.000 POR 1 1.01 0.981 0.027 1.17 0.634 0.021 POSTN 1 1.73 0.009 0.000 X 0.45 0.003 0.000 PPBP 6 1.77 0.000 0.000 1.17 0.085 0.000 PPIA 2 X 2.42 0.000 0.000 1.57 0.004 0.000 PPIB 0 — — — — — — PRAP1 0 — — — — — — PRDX2 4 X 2.88 0.000 0.000 0.84 0.173 0.000 PRDX6 1 X 2.26 0.000 0.000 1.38 0.104 0.000 PRG4 1 1.21 0.087 0.000 0.90 0.474 0.000 PROC 4 1.61 0.000 0.000 1.92 0.000 0.000 PROCR 1 X 2.27 0.000 0.000 1.12 0.643 0.000 PROS1 4 1.99 0.000 0.000 1.47 0.000 0.000 PROZ 3 1.85 0.000 0.000 1.54 0.001 0.000 PRSS1 0 — — — — — — PRSS3 1 1.95 0.000 0.000 1.27 0.075 0.000 PTGDS 1 1.46 0.007 0.000 0.66 0.021 0.000 PTPRG 0 — — — — — — PTPRJ 1 1.23 0.091 0.000 0.88 0.416 0.000 PTPRS 0 — — — — — — PVR 2 X 2.18 0.000 0.000 1.27 0.034 0.000 PVRL1 0 — — — — — — PZP 5 1.83 0.000 0.000 1.61 0.000 0.000 QSOX1 2 X 3.94 0.000 0.000 1.55 0.006 0.000 RBBP8 0 — — — — — — RNASE1 0 — — — — — — RTN4RL2 0 — — — — — — S100A12 0 — — — — — — S100A8 5 1.25 0.061 0.000 0.94 0.687 0.000 S100A9 8 X 3.68 0.000 0.000 1.37 0.002 0.000 SAA1 1 X 3.35 0.000 0.000 X 0.19 0.000 0.000 SAA4 3 0.60 0.000 0.000 0.65 0.009 0.000 SDPR 0 — — — — — — SELL 2 X 2.01 0.000 0.000 1.18 0.283 0.000 SEMA4B 0 — — — — — — SEPP1 3 1.24 0.023 0.000 1.89 0.000 0.000 SERPINA1 43 1.30 0.000 0.000 0.91 0.029 0.000 SERPINA10 1 1.70 0.000 0.000 1.61 0.001 0.000 SERPINA3 3 0.91 0.446 0.013 0.84 0.283 0.012 SERPINA4 7 X 2.13 0.000 0.000 X 2.19 0.000 0.000 SERPINA6 7 X 2.24 0.000 0.000 1.41 0.000 0.000 SERPINA7 17 X 2.43 0.000 0.000 1.56 0.000 0.000 SERPINB1 0 — — — — — — SERPINC1 2 0.71 0.000 0.000 1.29 0.025 0.000 SERPIND1 11 1.95 0.000 0.000 1.51 0.000 0.000 SERPINF1 25 X 2.03 0.000 0.000 1.29 0.000 0.000 SERPINF2 0 — — — — — — SERPING1 3 X 3.02 0.000 0.000 X 2.19 0.000 0.000 SH3BGRL 0 — — — — — — SH3BGRL3 3 X 2.52 0.000 0.000 1.73 0.000 0.000 SHBG 2 1.73 0.000 0.000 X 2.15 0.000 0.000 SLC3A2 0 — — — — — — SNCA 0 — — — — — — SNED1 0 — — — — — — SOD3 1 1.49 0.003 0.000 1.15 0.412 0.000 SORL1 0 — — — — — — SOWAHC 1 1.88 0.017 0.000 X 3.45 0.000 0.000 SPARC 3 1.78 0.000 0.000 0.67 0.000 0.000 SPARCL1 0 — — — — — — SPP2 0 — — — — — — SRGN 0 — — — — — — SSC5D 0 — — — — — — STXBP3 0 — — — — — — TAGLN2 1 X 2.58 0.000 0.000 X 3.31 0.000 0.000 TF 0 — — — — — — TGFBI 6 1.99 0.000 0.000 0.86 0.065 0.000 THBS1 7 1.62 0.000 0.000 1.88 0.000 0.000 TIMP1 0 — — — — — — TKT 1 0.66 0.001 0.000 1.09 0.592 0.000 TLN1 0 — — — — — — TMSB4X 1 1.33 0.000 0.000 1.14 0.202 0.000 TNC 2 X 2.08 0.000 0.000 0.68 0.003 0.000 TNXB 7 1.05 0.482 0.001 1.19 0.040 0.001 TPI1 1 X 2.14 0.000 0.000 0.78 0.210 0.000 TPM3 0 — — — — — — TPM4 0 — — — — — — TREML1 0 — — — — — — TTR 19 X 0.46 0.000 0.000 1.04 0.495 0.000 TUBA4A 0 — — — — — — UMOD 1 0.78 0.029 0.000 1.01 0.944 0.000 VASN 5 X 2.27 0.000 0.000 1.28 0.003 0.000 VASP 0 — — — — — — VCAM1 1 X 3.37 0.000 0.000 1.57 0.071 0.000 VCL 1 X 2.05 0.000 0.000 X 2.09 0.000 0.000 VIM 0 — — — — — — VNN1 0 — — — — — — VTN 0 — — — — — — VWF 8 X 2.58 0.000 0.000 X 2.26 0.000 0.000 YWHAE 0 — — — — — — YWHAG 0 — — — — — — YWHAZ 0 — — — — — — ZYX 0 — — — — — — *Differential expression (DE) thresholds: p-value <0.05|q-value <0.05|ANOVA DI >2

Example II. Biomarker Identification

As described in Example 1, plasma samples from subjects with active TB were compared to samples from subjects with latent TB or healthy controls, and proteins that were significantly differentially expressed in a condition-specific manner were identified (Table 1). A subset of these proteins was selected to include in a multiplex MRM assay. A second, independent set of samples was then analyzed with the MRM assay. The second set included samples from subjects with active TB, latent TB, healthy controls, as well as from subjects that had other respiratory diseases of similar clinical presentation as TB. This sample set also included subjects belonging to the 4 clinical groups indicated but which also had an HIV co-infection.

The data collected from the second set of clinical samples was used to define combinations of up to 4 biomarker proteins able to distinguish active TB from the other clinical groups, with and without HIV co-infection (see, e.g., Tables 3 and 4).

In order to confirm the utility of these markers and combinations of markers, additional statistical analyses were performed to characterize individual biomarkers and combinations of biomarkers (up to 4 candidates) that can be used to distinguish active TB from latent TB and other respiratory diseases in the presence or absence of HIV infection.

The statistical analysis was initiated using all of the candidate biomarkers in Table 1. The method split the data into five test sets, each with a proportion of Active TB samples to other respiratory disease samples as close as possible to that of the full data set. For each test set, four fifths of the data were defined to be that test set's corresponding training set. Each training set was again split at random by stratified sampling into two halves. One half was used to fit a logistic regression model, which was then used to calculate out-of-sample predictive scores for the other half. This random half-and-half split procedure was repeated a number of times equal to three times the sample size of the training set; out-of-sample predictive scores and the corresponding true outcomes were aggregated over all random splits and AUCs were estimated from these. Since there are five training sets, five such AUC estimates were generated for each panel, which were then averaged. Panel selection was carried out by examining various summaries of protein performance and also direct examination of the panels with the best AUC estimates. To compute the final AUC estimates of the selected panels, each test set was scored by a logistic regression model fit to the corresponding training set; the resulting out-of-sample predictive scores and true outcomes aggregated over all five test sets, forming the final set from which AUCs were estimated. This nested cross-validation approach reduced the risk of data overfitting, averaged out sampling artifacts, and provided independent performance testing.

The candidate biomarkers were then ranked by their ability to distinguish active TB from the other respiratory diseases individually and in combinations of up to 4 candidates, by the change in relative rank when the candidate biomarkers were used in panels, and by the frequency with which each biomarker appeared in the best performing panels. The HIV+ and HIV− groups were analyzed separately. Analysis of the ranking identified the best performing biomarkers for the HIV− (Tables 5-8) and HIV+ groups (Tables 9-12) which were able to accurately distinguish active TB from other respiratory diseases.

The performance of the individual biomarker candidates ranged between 0.428 to 0.804 AUC for the HIV− groups, and 0.625 to 0.770 AUC for the HIV+ groups (Tables 5 and 9).

Combining the biomarker candidates into panels was a more effective strategy to derive high performing discriminators (Tables 6-8 and 10-12). One of the 45 combinations of two candidate biomarker proteins (2%) assayed were able to improve the performance in the HIV− groups, but none of the combinations of two proteins assayed were able to improve the performance in the HIV+ groups. Sixteen of the 120 combinations of three candidate biomarker proteins (13%) assayed were able to improve the performance in the HIV− groups, and 8 of the 56 (14%) of the candidates assayed did the same in the HIV+ groups. Eighty-four of the 210 combinations of four candidate biomarker proteins (40%) assayed were able to improve the performance in the HIV− groups, and 37 of the 70 (53%) of the candidates assayed did the same in the HIV+ groups.

These results indicated it was possible to derive high performing panels from combinations of three or four candidates.

TABLE 5 HIV− panels Individual Candidate Biomarkers COMP 0.804 TNXB 0.795 LUM 0.794 CD14 0.756 SEPP1 0.721 QSOX1 0.716 APOC1 0.701 PEPD 0.673 APOE 0.629 SELL 0.596 MASP1 0.475 HIST2H2BE 0.447 GP1BA 0.428

TABLE 6 HIV− panels Combination of Two Candidate Biomarkers protein.1 protein.2 AUC PEPD SELL 0.847 SELL SEPP1 0.825 QSOX1 SELL 0.825 COMP SELL 0.823 CD14 LUM 0.822 APOC1 CD14 0.820 CD14 PEPD 0.818 CD14 SEPP1 0.816 APOE CD14 0.816 SELL TNXB 0.813 CD14 GP1BA 0.810 APOC1 COMP 0.809 CD14 TNXB 0.808 CD14 QSOX1 0.803 CD14 COMP 0.802 LUM SELL 0.796 APOE COMP 0.789 COMP TNXB 0.788 COMP SEPP1 0.782 LUM TNXB 0.778 LUM SEPP1 0.775 APOC1 LUM 0.772 COMP HIST2H2BE 0.769 CD14 MASP1 0.768 APOE LUM 0.765 LUM PEPD 0.761 COMP QSOX1 0.761 LUM QSOX1 0.761 COMP MASP1 0.760 COMP PEPD 0.759 COMP LUM 0.754 HIST2H2BE LUM 0.753 COMP GP1BA 0.750 QSOX1 TNXB 0.748 LUM MASP1 0.742 APOC1 TNXB 0.742 MASP1 TNXB 0.740 PEPD TNXB 0.739 GP1BA LUM 0.738 SEPP1 TNXB 0.738 GP1BA TNXB 0.738 HIST2H2BE TNXB 0.737 APOE TNXB 0.735 APOC1 QSOX1 0.731 APOC1 SELL 0.729 CD14 HIST2H2BE 0.722 CD14 SELL 0.720 QSOX1 SEPP1 0.717 MASP1 SEPP1 0.717 MASP1 SELL 0.702 GP1BA SEPP1 0.688 APOC1 PEPD 0.687 APOE QSOX1 0.684 PEPD SEPP1 0.679 APOC1 SEPP1 0.679 HIST2H2BE SEPP1 0.675 APOE SELL 0.670 APOE SEPP1 0.669 PEPD QSOX1 0.668 APOC1 APOE 0.662 HIST2H2BE QSOX1 0.658 MASP1 QSOX1 0.656 GP1BA QSOX1 0.655 GP1BA PEPD 0.647 APOC1 GP1BA 0.646 APOC1 MASP1 0.641 APOC1 HIST2H2BE 0.633 APOE PEPD 0.627 MASP1 PEPD 0.624 HIST2H2BE PEPD 0.612 APOE MASP1 0.573 APOE HIST2H2BE 0.573 GP1BA SELL 0.566 APOE GP1BA 0.563 HIST2H2BE SELL 0.554 HIST2H2BE MASP1 0.453 GP1BA MASP1 0.445 GP1BA HIST2H2BE 0.434

TABLE 7 HIV− panels Combination of Three Candidate Biomarkers protein.1 protein.2 protein.3 AUC PEPD SELL TNXB 0.999 COMP PEPD SELL 0.999 PEPD QSOX1 SELL 0.966 CD14 PEPD SELL 0.956 PEPD SELL SEPP1 0.946 LUM PEPD SELL 0.931 SELL SEPP1 TNXB 0.912 APOC1 QSOX1 SELL 0.906 CD14 HIST2H2BE SEPP1 0.902 QSOX1 SELL TNXB 0.901 COMP SELL SEPP1 0.901 LUM SELL SEPP1 0.896 QSOX1 SELL SEPP1 0.891 APOE CD14 GP1BA 0.876 APOC1 CD14 PEPD 0.870 CD14 HIST2H2BE LUM 0.863 MASP1 QSOX1 SELL 0.860 APOC1 COMP SELL 0.854 APOC1 CD14 QSOX1 0.853 COMP MASP1 SELL 0.850 CD14 HIST2H2BE PEPD 0.849 APOC1 PEPD SELL 0.848 APOC1 CD14 COMP 0.842 MASP1 PEPD SELL 0.841 APOC1 LUM SELL 0.841 COMP SELL TNXB 0.840 APOC1 CD14 GP1BA 0.839 CD14 GP1BA TNXB 0.838 CD14 GP1BA SEPP1 0.837 COMP QSOX1 SELL 0.837 GP1BA PEPD SELL 0.834 APOC1 CD14 LUM 0.833 APOC1 APOE CD14 0.831 CD14 COMP GP1BA 0.829 CD14 GP1BA LUM 0.829 APOE CD14 PEPD 0.829 CD14 SELL TNXB 0.827 CD14 GP1BA QSOX1 0.823 CD14 LUM TNXB 0.823 APOE COMP SELL 0.823 COMP GP1BA SELL 0.822 MASP1 SELL TNXB 0.822 APOE SELL TNXB 0.822 APOC1 CD14 TNXB 0.821 APOE SELL SEPP1 0.820 CD14 SELL SEPP1 0.819 CD14 LUM SEPP1 0.818 APOE CD14 LUM 0.818 HIST2H2BE PEPD SELL 0.817 APOE CD14 TNXB 0.817 LUM QSOX1 SELL 0.813 APOC1 CD14 HIST2H2BE 0.812 APOE QSOX1 SELL 0.809 COMP HIST2H2BE SELL 0.807 APOE PEPD SELL 0.807 CD14 HIST2H2BE TNXB 0.804 CD14 COMP HIST2H2BE 0.803 APOE CD14 MASP1 0.803 CD14 GP1BA PEPD 0.803 CD14 COMP TNXB 0.803 LUM SELL TNXB 0.802 GP1BA QSOX1 SELL 0.800 CD14 PEPD TNXB 0.800 CD14 LUM PEPD 0.800 CD14 QSOX1 SELL 0.799 CD14 SEPP1 TNXB 0.797 APOE CD14 COMP 0.797 CD14 QSOX1 TNXB 0.796 APOC1 SELL TNXB 0.795 APOE CD14 QSOX1 0.794 CD14 COMP SELL 0.793 CD14 PEPD SEPP1 0.792 CD14 LUM SELL 0.792 APOE CD14 SELL 0.792 APOC1 CD14 SEPP1 0.791 HIST2H2BE SELL SEPP1 0.791 APOE CD14 HIST2H2BE 0.791 CD14 QSOX1 SEPP1 0.790 MASP1 SELL SEPP1 0.790 CD14 LUM MASP1 0.789 GP1BA SELL SEPP1 0.788 HIST2H2BE SELL TNXB 0.787 CD14 COMP SEPP1 0.786 APOC1 SELL SEPP1 0.786 CD14 MASP1 SELL 0.785 GP1BA SELL TNXB 0.784 CD14 GP1BA MASP1 0.784 APOE CD14 SEPP1 0.784 HIST2H2BE QSOX1 SELL 0.783 CD14 GP1BA SELL 0.783 APOC1 CD14 SELL 0.782 APOC1 CD14 MASP1 0.780 CD14 LUM QSOX1 0.778 CD14 HIST2H2BE QSOX1 0.778 APOE LUM SELL 0.776 COMP LUM SELL 0.776 GP1BA LUM SELL 0.773 CD14 MASP1 TNXB 0.773 CD14 COMP PEPD 0.772 APOC1 COMP MASP1 0.770 LUM MASP1 SELL 0.770 CD14 PEPD QSOX1 0.769 CD14 COMP MASP1 0.768 CD14 COMP LUM 0.767 CD14 MASP1 QSOX1 0.766 CD14 MASP1 SEPP1 0.764 APOC1 COMP PEPD 0.763 APOC1 COMP TNXB 0.762 CD14 GP1BA HIST2H2BE 0.761 HIST2H2BE LUM SELL 0.761 APOC1 APOE COMP 0.759 CD14 MASP1 PEPD 0.757 APOC1 COMP QSOX1 0.756 APOC1 COMP SEPP1 0.755 APOC1 COMP GP1BA 0.754 APOE COMP MASP1 0.754 APOC1 COMP HIST2H2BE 0.752 APOC1 COMP LUM 0.752 COMP MASP1 TNXB 0.752 COMP HIST2H2BE TNXB 0.750 CD14 COMP QSOX1 0.749 COMP PEPD TNXB 0.746 APOE COMP TNXB 0.745 LUM MASP1 TNXB 0.744 CD14 HIST2H2BE MASP1 0.744 COMP SEPP1 TNXB 0.743 COMP GP1BA TNXB 0.743 HIST2H2BE LUM TNXB 0.742 COMP MASP1 SEPP1 0.740 LUM MASP1 SEPP1 0.740 LUM SEPP1 TNXB 0.740 APOE COMP GP1BA 0.738 COMP QSOX1 SEPP1 0.737 LUM QSOX1 TNXB 0.737 APOE COMP PEPD 0.736 COMP QSOX1 TNXB 0.736 COMP LUM TNXB 0.736 COMP HIST2H2BE SEPP1 0.736 APOE COMP SEPP1 0.736 GP1BA LUM TNXB 0.736 APOC1 LUM QSOX1 0.736 APOE LUM TNXB 0.735 LUM PEPD TNXB 0.735 APOC1 LUM TNXB 0.734 APOC1 LUM PEPD 0.733 LUM QSOX1 SEPP1 0.733 COMP GP1BA SEPP1 0.730 APOE COMP HIST2H2BE 0.730 COMP LUM SEPP1 0.729 APOC1 HIST2H2BE LUM 0.728 APOE COMP QSOX1 0.728 COMP PEPD SEPP1 0.728 HIST2H2BE LUM SEPP1 0.728 APOE COMP LUM 0.727 COMP HIST2H2BE MASP1 0.727 APOC1 LUM MASP1 0.726 LUM PEPD SEPP1 0.726 APOE LUM PEPD 0.725 COMP HIST2H2BE PEPD 0.725 APOE LUM QSOX1 0.725 APOE LUM SEPP1 0.724 MASP1 SEPP1 TNXB 0.724 APOE LUM MASP1 0.724 COMP HIST2H2BE LUM 0.724 APOE GP1BA LUM 0.724 COMP HIST2H2BE QSOX1 0.723 APOC1 LUM SEPP1 0.723 APOC1 GP1BA LUM 0.723 APOC1 APOE LUM 0.721 GP1BA LUM SEPP1 0.720 COMP GP1BA HIST2H2BE 0.718 APOE HIST2H2BE LUM 0.718 COMP MASP1 QSOX1 0.717 COMP GP1BA PEPD 0.714 APOC1 MASP1 QSOX1 0.714 COMP LUM PEPD 0.714 APOC1 MASP1 SELL 0.714 HIST2H2BE LUM QSOX1 0.714 COMP LUM MASP1 0.713 COMP GP1BA MASP1 0.713 HIST2H2BE LUM PEPD 0.712 GP1BA LUM PEPD 0.712 LUM MASP1 PEPD 0.711 COMP LUM QSOX1 0.711 APOC1 QSOX1 TNXB 0.711 LUM PEPD QSOX1 0.711 COMP GP1BA LUM 0.710 LUM MASP1 QSOX1 0.710 MASP1 QSOX1 TNXB 0.709 APOC1 APOE SELL 0.709 COMP MASP1 PEPD 0.709 MASP1 QSOX1 SEPP1 0.708 GP1BA LUM QSOX1 0.707 QSOX1 SEPP1 TNXB 0.706 GP1BA PEPD TNXB 0.706 MASP1 PEPD TNXB 0.706 GP1BA QSOX1 TNXB 0.706 GP1BA HIST2H2BE LUM 0.703 APOC1 MASP1 TNXB 0.703 COMP PEPD QSOX1 0.702 HIST2H2BE QSOX1 TNXB 0.701 APOC1 PEPD TNXB 0.701 COMP GP1BA QSOX1 0.701 APOC1 GP1BA TNXB 0.700 GP1BA SEPP1 TNXB 0.700 PEPD QSOX1 TNXB 0.699 APOE QSOX1 TNXB 0.698 HIST2H2BE SEPP1 TNXB 0.697 APOE GP1BA TNXB 0.697 APOE MASP1 SELL 0.696 HIST2H2BE LUM MASP1 0.694 APOE MASP1 TNXB 0.694 APOC1 HIST2H2BE TNXB 0.693 PEPD SEPP1 TNXB 0.690 GP1BA LUM MASP1 0.690 GP1BA HIST2H2BE TNXB 0.689 APOC1 GP1BA QSOX1 0.688 HIST2H2BE PEPD TNXB 0.688 APOC1 APOE TNXB 0.687 APOE PEPD TNXB 0.687 HIST2H2BE MASP1 TNXB 0.686 APOC1 APOE QSOX1 0.686 APOC1 HIST2H2BE QSOX1 0.684 APOC1 QSOX1 SEPP1 0.683 APOE HIST2H2BE TNXB 0.683 APOC1 HIST2H2BE SELL 0.683 APOC1 SEPP1 TNXB 0.682 APOE SEPP1 TNXB 0.681 MASP1 PEPD SEPP1 0.681 APOC1 PEPD QSOX1 0.679 APOC1 MASP1 SEPP1 0.678 GP1BA MASP1 TNXB 0.676 APOC1 GP1BA SELL 0.676 GP1BA QSOX1 SEPP1 0.676 GP1BA MASP1 SEPP1 0.674 CD14 HIST2H2BE SELL 0.674 APOC1 GP1BA PEPD 0.672 HIST2H2BE QSOX1 SEPP1 0.672 HIST2H2BE MASP1 SEPP1 0.672 GP1BA PEPD SEPP1 0.668 HIST2H2BE MASP1 SELL 0.666 APOE MASP1 SEPP1 0.660 PEPD QSOX1 SEPP1 0.659 APOE QSOX1 SEPP1 0.657 APOC1 MASP1 PEPD 0.657 GP1BA MASP1 SELL 0.657 APOC1 PEPD SEPP1 0.649 APOC1 GP1BA SEPP1 0.649 APOE HIST2H2BE SELL 0.647 GP1BA HIST2H2BE SEPP1 0.647 APOE MASP1 QSOX1 0.643 HIST2H2BE PEPD SEPP1 0.636 APOE GP1BA SEPP1 0.636 GP1BA PEPD QSOX1 0.636 APOC1 HIST2H2BE SEPP1 0.636 APOE HIST2H2BE QSOX1 0.635 APOE GP1BA QSOX1 0.635 APOE PEPD QSOX1 0.633 APOC1 APOE PEPD 0.632 APOC1 HIST2H2BE PEPD 0.629 MASP1 PEPD QSOX1 0.629 APOC1 APOE SEPP1 0.628 APOC1 APOE MASP1 0.624 APOC1 APOE GP1BA 0.624 APOE HIST2H2BE SEPP1 0.623 HIST2H2BE PEPD QSOX1 0.622 APOE GP1BA SELL 0.621 GP1BA MASP1 PEPD 0.620 APOE GP1BA PEPD 0.620 GP1BA MASP1 QSOX1 0.617 APOE PEPD SEPP1 0.616 GP1BA HIST2H2BE QSOX1 0.613 HIST2H2BE MASP1 QSOX1 0.609 GP1BA HIST2H2BE PEPD 0.606 APOC1 APOE HIST2H2BE 0.605 APOE MASP1 PEPD 0.600 APOC1 GP1BA HIST2H2BE 0.598 APOC1 GP1BA MASP1 0.587 APOC1 HIST2H2BE MASP1 0.587 HIST2H2BE MASP1 PEPD 0.578 APOE HIST2H2BE PEPD 0.576 GP1BA HIST2H2BE SELL 0.573 APOE HIST2H2BE MASP1 0.536 APOE GP1BA HIST2H2BE 0.534 APOE GP1BA MASP1 0.527 GP1BA HIST2H2BE MASP1 0.435

TABLE 8 HIV− panels Combination of Four Candidate Biomarkers protein.1 protein.2 protein.3 protein.4 AUC MASP1 PEPD QSOX1 SELL 1.000 GP1BA PEPD SELL TNXB 1.000 COMP PEPD SELL TNXB 1.000 COMP PEPD QSOX1 SELL 1.000 COMP LUM PEPD SELL 1.000 COMP HIST2H2BE PEPD SELL 1.000 CD14 PEPD SELL TNXB 1.000 CD14 PEPD SELL SEPP1 1.000 CD14 PEPD QSOX1 SELL 1.000 CD14 HIST2H2BE PEPD SELL 1.000 APOE COMP PEPD SELL 1.000 COMP GP1BA PEPD SELL 1.000 APOC1 COMP PEPD SELL 1.000 LUM PEPD SELL TNXB 1.000 HIST2H2BE LUM PEPD SELL 1.000 COMP MASP1 PEPD SELL 1.000 APOC1 CD14 PEPD SELL 1.000 APOC1 CD14 HIST2H2BE LUM 1.000 COMP PEPD SELL SEPP1 1.000 PEPD QSOX1 SELL TNXB 1.000 APOE LUM PEPD SELL 1.000 CD14 MASP1 PEPD SELL 1.000 LUM PEPD SELL SEPP1 1.000 CD14 COMP PEPD SELL 1.000 PEPD SELL SEPP1 TNXB 1.000 CD14 HIST2H2BE SEPP1 TNXB 1.000 CD14 GP1BA PEPD SELL 1.000 MASP1 PEPD SELL TNXB 1.000 APOC1 PEPD SELL TNXB 0.999 APOC1 APOE CD14 GP1BA 0.999 PEPD QSOX1 SELL SEPP1 0.999 CD14 LUM PEPD SELL 0.999 LUM PEPD QSOX1 SELL 0.999 APOC1 MASP1 QSOX1 SELL 0.999 APOE PEPD QSOX1 SELL 0.999 MASP1 PEPD SELL SEPP1 0.999 APOC1 COMP SELL SEPP1 0.999 CD14 GP1BA HIST2H2BE SEPP1 0.999 CD14 HIST2H2BE PEPD TNXB 0.998 HIST2H2BE PEPD SELL TNXB 0.998 APOC1 CD14 COMP HIST2H2BE 0.998 GP1BA PEPD QSOX1 SELL 0.998 APOC1 CD14 HIST2H2BE SEPP1 0.998 APOE PEPD SELL TNXB 0.997 COMP HIST2H2BE SELL SEPP1 0.997 APOC1 LUM PEPD SELL 0.996 LUM MASP1 PEPD SELL 0.995 APOC1 PEPD QSOX1 SELL 0.981 MASP1 QSOX1 SELL TNXB 0.981 APOC1 PEPD SELL SEPP1 0.980 APOC1 COMP MASP1 SELL 0.979 APOC1 COMP QSOX1 SELL 0.977 APOC1 CD14 QSOX1 SELL 0.976 APOC1 QSOX1 SELL SEPP1 0.976 MASP1 QSOX1 SELL SEPP1 0.969 APOE CD14 PEPD SELL 0.967 HIST2H2BE PEPD QSOX1 SELL 0.964 CD14 MASP1 QSOX1 SELL 0.963 APOC1 LUM QSOX1 SELL 0.961 CD14 HIST2H2BE LUM SEPP1 0.960 CD14 HIST2H2BE PEPD SEPP1 0.956 CD14 GP1BA QSOX1 SELL 0.956 APOE CD14 GP1BA LUM 0.956 GP1BA LUM PEPD SELL 0.955 APOE CD14 GP1BA SEPP1 0.951 APOE COMP SELL SEPP1 0.950 APOC1 QSOX1 SELL TNXB 0.949 APOE SELL SEPP1 TNXB 0.946 HIST2H2BE PEPD SELL SEPP1 0.946 HIST2H2BE SELL SEPP1 TNXB 0.945 GP1BA PEPD SELL SEPP1 0.944 APOE PEPD SELL SEPP1 0.942 APOE CD14 HIST2H2BE TNXB 0.942 HIST2H2BE QSOX1 SELL SEPP1 0.940 MASP1 SELL SEPP1 TNXB 0.938 QSOX1 SELL SEPP1 TNXB 0.937 APOE CD14 HIST2H2BE SEPP1 0.936 LUM QSOX1 SELL SEPP1 0.934 APOE MASP1 QSOX1 SELL 0.934 APOC1 HIST2H2BE QSOX1 SELL 0.933 APOC1 CD14 HIST2H2BE TNXB 0.933 APOE COMP MASP1 SELL 0.932 APOE CD14 GP1BA TNXB 0.932 CD14 HIST2H2BE QSOX1 SEPP1 0.931 COMP GP1BA SELL SEPP1 0.931 APOE CD14 COMP HIST2H2BE 0.928 CD14 COMP HIST2H2BE SEPP1 0.927 APOC1 GP1BA PEPD SELL 0.927 COMP QSOX1 SELL SEPP1 0.927 APOE CD14 COMP GP1BA 0.927 APOE CD14 GP1BA SELL 0.926 APOE CD14 GP1BA MASP1 0.926 APOE CD14 GP1BA PEPD 0.925 APOC1 CD14 HIST2H2BE QSOX1 0.925 APOE CD14 GP1BA QSOX1 0.924 COMP LUM SELL SEPP1 0.922 CD14 HIST2H2BE LUM PEPD 0.921 CD14 MASP1 SELL TNXB 0.920 CD14 QSOX1 SELL SEPP1 0.919 APOE LUM SELL SEPP1 0.919 HIST2H2BE LUM SELL SEPP1 0.916 APOE CD14 HIST2H2BE PEPD 0.916 APOE CD14 HIST2H2BE LUM 0.916 APOE QSOX1 SELL TNXB 0.916 COMP MASP1 SELL SEPP1 0.914 APOE QSOX1 SELL SEPP1 0.914 COMP SELL SEPP1 TNXB 0.913 APOC1 CD14 GP1BA QSOX1 0.912 CD14 QSOX1 SELL TNXB 0.911 APOC1 CD14 HIST2H2BE PEPD 0.911 CD14 HIST2H2BE MASP1 SEPP1 0.909 APOC1 SELL SEPP1 TNXB 0.908 CD14 HIST2H2BE SELL SEPP1 0.907 COMP HIST2H2BE MASP1 SELL 0.906 LUM MASP1 SELL SEPP1 0.905 APOC1 GP1BA QSOX1 SELL 0.902 APOE CD14 SELL TNXB 0.901 APOC1 CD14 GP1BA PEPD 0.901 CD14 COMP GP1BA SELL 0.901 APOC1 CD14 GP1BA TNXB 0.900 COMP MASP1 QSOX1 SELL 0.900 APOC1 CD14 COMP GP1BA 0.900 COMP QSOX1 SELL TNXB 0.900 HIST2H2BE QSOX1 SELL TNXB 0.900 GP1BA QSOX1 SELL TNXB 0.898 COMP MASP1 SELL TNXB 0.898 LUM QSOX1 SELL TNXB 0.897 CD14 HIST2H2BE PEPD QSOX1 0.897 GP1BA QSOX1 SELL SEPP1 0.897 APOC1 LUM SELL SEPP1 0.897 CD14 GP1BA HIST2H2BE LUM 0.896 GP1BA MASP1 PEPD SELL 0.895 APOC1 CD14 GP1BA LUM 0.895 APOE MASP1 PEPD SELL 0.894 GP1BA SELL SEPP1 TNXB 0.891 CD14 LUM SELL SEPP1 0.889 CD14 COMP SELL TNXB 0.888 APOE CD14 GP1BA HIST2H2BE 0.888 CD14 SELL SEPP1 TNXB 0.887 LUM MASP1 QSOX1 SELL 0.886 COMP HIST2H2BE QSOX1 SELL 0.885 GP1BA LUM SELL SEPP1 0.884 CD14 COMP GP1BA HIST2H2BE 0.884 CD14 COMP SELL SEPP1 0.883 CD14 COMP MASP1 SELL 0.883 HIST2H2BE MASP1 QSOX1 SELL 0.883 APOC1 LUM MASP1 SELL 0.883 APOC1 COMP HIST2H2BE SELL 0.882 LUM SELL SEPP1 TNXB 0.882 APOC1 APOE COMP SELL 0.879 GP1BA MASP1 QSOX1 SELL 0.877 CD14 HIST2H2BE LUM MASP1 0.877 APOC1 CD14 SELL TNXB 0.876 CD14 GP1BA SELL TNXB 0.876 APOC1 CD14 GP1BA SEPP1 0.876 CD14 COMP HIST2H2BE SELL 0.874 APOC1 CD14 LUM SELL 0.874 APOC1 CD14 MASP1 PEPD 0.872 CD14 HIST2H2BE LUM SELL 0.872 APOC1 COMP GP1BA SELL 0.871 APOC1 CD14 COMP SELL 0.870 HIST2H2BE MASP1 PEPD SELL 0.870 APOE CD14 QSOX1 SELL 0.869 APOC1 MASP1 PEPD SELL 0.869 CD14 HIST2H2BE LUM TNXB 0.869 APOE CD14 COMP SELL 0.868 APOC1 APOE CD14 LUM 0.868 APOE CD14 MASP1 SELL 0.867 CD14 LUM MASP1 SELL 0.867 APOE CD14 LUM PEPD 0.867 APOE CD14 LUM SELL 0.867 APOC1 CD14 LUM PEPD 0.865 COMP LUM SELL TNXB 0.865 COMP GP1BA MASP1 SELL 0.864 CD14 GP1BA SELL SEPP1 0.864 CD14 LUM SELL TNXB 0.864 CD14 GP1BA HIST2H2BE PEPD 0.863 CD14 GP1BA LUM SELL 0.863 APOC1 CD14 GP1BA HIST2H2BE 0.863 CD14 COMP HIST2H2BE TNXB 0.862 APOC1 COMP LUM SELL 0.861 APOE COMP SELL TNXB 0.861 CD14 HIST2H2BE LUM QSOX1 0.860 APOC1 COMP SELL TNXB 0.860 CD14 COMP GP1BA SEPP1 0.859 CD14 GP1BA LUM SEPP1 0.859 CD14 GP1BA SEPP1 TNXB 0.858 APOE CD14 LUM MASP1 0.858 APOC1 HIST2H2BE PEPD SELL 0.858 APOC1 APOE CD14 PEPD 0.856 CD14 HIST2H2BE QSOX1 TNXB 0.855 APOC1 CD14 QSOX1 SEPP1 0.855 CD14 HIST2H2BE SELL TNXB 0.855 CD14 GP1BA HIST2H2BE TNXB 0.854 APOE CD14 SELL SEPP1 0.853 APOC1 CD14 COMP PEPD 0.850 APOE CD14 HIST2H2BE MASP1 0.849 COMP GP1BA SELL TNXB 0.849 APOE CD14 MASP1 TNXB 0.849 COMP GP1BA HIST2H2BE SELL 0.848 APOC1 CD14 LUM QSOX1 0.848 APOC1 APOE CD14 HIST2H2BE 0.848 APOC1 CD14 PEPD TNXB 0.848 COMP LUM MASP1 SELL 0.848 APOC1 CD14 MASP1 QSOX1 0.846 APOC1 APOE CD14 TNXB 0.845 APOE COMP QSOX1 SELL 0.844 COMP HIST2H2BE SELL TNXB 0.843 CD14 COMP HIST2H2BE LUM 0.843 APOC1 APOE LUM SELL 0.843 CD14 GP1BA LUM TNXB 0.843 CD14 COMP GP1BA TNXB 0.843 CD14 GP1BA QSOX1 TNXB 0.841 CD14 GP1BA PEPD TNXB 0.841 APOC1 APOE CD14 SELL 0.841 APOE MASP1 SELL TNXB 0.841 APOC1 CD14 PEPD SEPP1 0.841 CD14 COMP LUM SEPP1 0.840 CD14 GP1BA QSOX1 SEPP1 0.837 APOC1 CD14 LUM TNXB 0.837 CD14 GP1BA HIST2H2BE QSOX1 0.836 APOC1 CD14 QSOX1 TNXB 0.836 APOC1 CD14 GP1BA SELL 0.836 APOC1 CD14 COMP QSOX1 0.836 CD14 MASP1 PEPD TNXB 0.836 APOC1 CD14 PEPD QSOX1 0.835 CD14 LUM MASP1 TNXB 0.835 CD14 GP1BA PEPD SEPP1 0.834 APOE COMP LUM SELL 0.834 COMP GP1BA QSOX1 SELL 0.833 LUM MASP1 SELL TNXB 0.833 APOE CD14 PEPD TNXB 0.833 APOC1 APOE CD14 QSOX1 0.832 CD14 HIST2H2BE MASP1 PEPD 0.830 APOC1 CD14 COMP LUM 0.830 APOE LUM QSOX1 SELL 0.828 APOE CD14 COMP PEPD 0.827 CD14 GP1BA MASP1 SELL 0.827 CD14 GP1BA MASP1 TNXB 0.827 GP1BA HIST2H2BE PEPD SELL 0.827 CD14 COMP LUM TNXB 0.826 CD14 LUM SEPP1 TNXB 0.826 APOC1 CD14 COMP SEPP1 0.825 HIST2H2BE LUM QSOX1 SELL 0.825 APOE LUM SELL TNXB 0.824 APOC1 APOE CD14 COMP 0.823 CD14 GP1BA MASP1 SEPP1 0.823 APOE GP1BA PEPD SELL 0.823 CD14 GP1BA MASP1 QSOX1 0.823 APOE CD14 HIST2H2BE QSOX1 0.823 APOC1 CD14 COMP MASP1 0.822 APOC1 APOE PEPD SELL 0.822 APOC1 LUM SELL TNXB 0.822 APOC1 CD14 LUM MASP1 0.822 APOE CD14 LUM QSOX1 0.820 HIST2H2BE MASP1 SELL TNXB 0.820 APOE COMP GP1BA SELL 0.820 APOE CD14 PEPD SEPP1 0.820 CD14 LUM QSOX1 SELL 0.819 CD14 COMP GP1BA MASP1 0.819 CD14 COMP GP1BA PEPD 0.819 CD14 COMP QSOX1 SELL 0.818 APOC1 CD14 MASP1 TNXB 0.817 APOE CD14 LUM SEPP1 0.817 CD14 LUM PEPD SEPP1 0.817 APOE COMP HIST2H2BE SELL 0.817 APOC1 HIST2H2BE LUM SELL 0.817 APOC1 CD14 COMP TNXB 0.816 APOC1 CD14 SEPP1 TNXB 0.816 GP1BA LUM QSOX1 SELL 0.816 APOE MASP1 SELL SEPP1 0.816 CD14 GP1BA LUM PEPD 0.816 CD14 GP1BA LUM MASP1 0.815 APOE CD14 MASP1 PEPD 0.815 APOC1 CD14 LUM SEPP1 0.814 CD14 GP1BA LUM QSOX1 0.811 CD14 LUM QSOX1 TNXB 0.811 CD14 GP1BA HIST2H2BE MASP1 0.810 APOE CD14 COMP LUM 0.809 APOE CD14 LUM TNXB 0.808 APOC1 APOE CD14 SEPP1 0.808 CD14 COMP GP1BA LUM 0.808 CD14 LUM QSOX1 SEPP1 0.808 APOC1 GP1BA LUM SELL 0.807 APOC1 CD14 HIST2H2BE MASP1 0.806 APOC1 APOE SELL TNXB 0.806 CD14 GP1BA PEPD QSOX1 0.806 HIST2H2BE LUM SELL TNXB 0.806 GP1BA LUM SELL TNXB 0.804 COMP GP1BA LUM SELL 0.804 APOC1 MASP1 SELL TNXB 0.804 APOE GP1BA QSOX1 SELL 0.804 CD14 LUM PEPD TNXB 0.804 CD14 MASP1 SELL SEPP1 0.804 CD14 COMP GP1BA QSOX1 0.803 APOC1 CD14 GP1BA MASP1 0.803 APOC1 APOE CD14 MASP1 0.801 APOC1 CD14 SELL SEPP1 0.800 APOE LUM MASP1 SELL 0.800 APOE CD14 SEPP1 TNXB 0.800 CD14 COMP MASP1 TNXB 0.799 CD14 MASP1 QSOX1 TNXB 0.797 COMP LUM QSOX1 SELL 0.797 CD14 COMP HIST2H2BE MASP1 0.796 CD14 HIST2H2BE QSOX1 SELL 0.796 APOE HIST2H2BE SELL SEPP1 0.795 HIST2H2BE MASP1 SELL SEPP1 0.795 CD14 LUM MASP1 PEPD 0.795 APOE CD14 PEPD QSOX1 0.794 APOE HIST2H2BE SELL TNXB 0.794 GP1BA MASP1 SELL TNXB 0.794 CD14 HIST2H2BE MASP1 QSOX1 0.794 APOC1 CD14 HIST2H2BE SELL 0.793 APOE CD14 QSOX1 TNXB 0.793 APOE GP1BA SELL TNXB 0.792 CD14 COMP PEPD SEPP1 0.792 CD14 HIST2H2BE MASP1 TNXB 0.792 APOE CD14 COMP MASP1 0.792 CD14 COMP HIST2H2BE QSOX1 0.792 APOC1 APOE SELL SEPP1 0.791 CD14 MASP1 SEPP1 TNXB 0.791 CD14 LUM MASP1 SEPP1 0.791 APOE GP1BA SELL SEPP1 0.790 CD14 PEPD SEPP1 TNXB 0.790 CD14 COMP LUM PEPD 0.789 GP1BA HIST2H2BE QSOX1 SELL 0.789 APOE HIST2H2BE PEPD SELL 0.787 APOE CD14 COMP TNXB 0.785 COMP HIST2H2BE LUM SELL 0.785 APOE HIST2H2BE QSOX1 SELL 0.781 CD14 COMP SEPP1 TNXB 0.781 CD14 GP1BA MASP1 PEPD 0.779 APOE CD14 HIST2H2BE SELL 0.779 APOE CD14 MASP1 QSOX1 0.778 CD14 COMP LUM SELL 0.777 APOE CD14 QSOX1 SEPP1 0.776 APOC1 CD14 MASP1 SELL 0.775 APOC1 CD14 MASP1 SEPP1 0.774 APOE CD14 COMP SEPP1 0.772 GP1BA MASP1 SELL SEPP1 0.772 APOC1 HIST2H2BE SELL SEPP1 0.771 APOE GP1BA LUM SELL 0.770 APOE CD14 COMP QSOX1 0.770 APOE CD14 MASP1 SEPP1 0.769 APOC1 HIST2H2BE SELL TNXB 0.768 CD14 COMP PEPD TNXB 0.768 CD14 QSOX1 SEPP1 TNXB 0.764 APOC1 GP1BA SELL TNXB 0.764 CD14 LUM PEPD QSOX1 0.764 CD14 HIST2H2BE MASP1 SELL 0.763 CD14 COMP QSOX1 TNXB 0.763 CD14 MASP1 PEPD SEPP1 0.763 APOC1 MASP1 SELL SEPP1 0.762 CD14 PEPD QSOX1 TNXB 0.761 GP1BA HIST2H2BE SELL TNXB 0.760 APOC1 GP1BA SELL SEPP1 0.759 CD14 LUM MASP1 QSOX1 0.759 GP1BA HIST2H2BE SELL SEPP1 0.751 CD14 COMP LUM MASP1 0.750 GP1BA LUM MASP1 SELL 0.750 CD14 GP1BA HIST2H2BE SELL 0.749 CD14 PEPD QSOX1 SEPP1 0.749 CD14 COMP MASP1 PEPD 0.748 CD14 COMP QSOX1 SEPP1 0.748 CD14 COMP MASP1 SEPP1 0.747 HIST2H2BE LUM MASP1 SELL 0.746 APOC1 APOE COMP MASP1 0.746 APOE HIST2H2BE LUM SELL 0.746 APOC1 COMP MASP1 TNXB 0.744 CD14 MASP1 QSOX1 SEPP1 0.743 APOC1 COMP HIST2H2BE MASP1 0.742 CD14 COMP PEPD QSOX1 0.738 APOC1 COMP MASP1 SEPP1 0.737 GP1BA HIST2H2BE LUM SELL 0.737 CD14 COMP LUM QSOX1 0.735 CD14 COMP MASP1 QSOX1 0.734 APOC1 COMP LUM MASP1 0.734 APOC1 COMP MASP1 QSOX1 0.733 APOC1 COMP GP1BA MASP1 0.732 APOE COMP MASP1 TNXB 0.728 APOC1 COMP HIST2H2BE TNXB 0.727 CD14 MASP1 PEPD QSOX1 0.726 COMP HIST2H2BE MASP1 TNXB 0.726 APOC1 COMP HIST2H2BE PEPD 0.725 APOC1 COMP GP1BA TNXB 0.723 APOC1 COMP HIST2H2BE QSOX1 0.723 APOC1 COMP MASP1 PEPD 0.722 APOC1 APOE COMP PEPD 0.722 APOC1 COMP GP1BA HIST2H2BE 0.720 COMP MASP1 SEPP1 TNXB 0.720 APOC1 COMP PEPD TNXB 0.720 APOC1 COMP QSOX1 TNXB 0.720 LUM MASP1 SEPP1 TNXB 0.719 APOC1 COMP HIST2H2BE LUM 0.719 APOC1 COMP PEPD SEPP1 0.718 APOC1 APOE COMP GP1BA 0.716 APOC1 COMP SEPP1 TNXB 0.716 APOE LUM MASP1 TNXB 0.715 COMP HIST2H2BE PEPD TNXB 0.714 HIST2H2BE LUM MASP1 TNXB 0.714 APOC1 COMP PEPD QSOX1 0.713 APOC1 COMP QSOX1 SEPP1 0.712 COMP MASP1 PEPD TNXB 0.711 APOC1 COMP GP1BA QSOX1 0.710 COMP LUM MASP1 TNXB 0.710 APOC1 COMP GP1BA SEPP1 0.709 APOC1 COMP GP1BA PEPD 0.708 APOC1 APOE COMP TNXB 0.708 APOE COMP PEPD TNXB 0.708 COMP MASP1 QSOX1 TNXB 0.708 APOE COMP GP1BA MASP1 0.707 APOE COMP GP1BA TNXB 0.707 APOC1 COMP HIST2H2BE SEPP1 0.707 COMP GP1BA MASP1 SEPP1 0.706 APOC1 APOE COMP QSOX1 0.706 COMP GP1BA PEPD TNXB 0.705 COMP GP1BA HIST2H2BE TNXB 0.705 APOC1 COMP GP1BA LUM 0.705 APOE GP1BA LUM TNXB 0.705 APOC1 APOE COMP SEPP1 0.704 COMP HIST2H2BE LUM TNXB 0.702 COMP HIST2H2BE SEPP1 TNXB 0.702 COMP HIST2H2BE MASP1 SEPP1 0.702 APOC1 COMP LUM PEPD 0.702 APOC1 APOE COMP HIST2H2BE 0.702 APOC1 COMP LUM TNXB 0.702 APOC1 COMP LUM SEPP1 0.701 LUM MASP1 QSOX1 SEPP1 0.701 LUM MASP1 PEPD TNXB 0.701 COMP GP1BA SEPP1 TNXB 0.701 APOE COMP HIST2H2BE TNXB 0.700 COMP LUM MASP1 SEPP1 0.699 APOC1 COMP LUM QSOX1 0.699 COMP PEPD SEPP1 TNXB 0.699 APOE COMP MASP1 SEPP1 0.699 COMP HIST2H2BE QSOX1 SEPP1 0.699 APOC1 APOE COMP LUM 0.698 COMP HIST2H2BE LUM SEPP1 0.698 LUM MASP1 QSOX1 TNXB 0.698 COMP GP1BA MASP1 TNXB 0.698 GP1BA LUM PEPD TNXB 0.698 APOE COMP HIST2H2BE MASP1 0.697 GP1BA HIST2H2BE LUM TNXB 0.697 GP1BA LUM MASP1 SEPP1 0.697 APOC1 LUM MASP1 TNXB 0.697 LUM MASP1 PEPD SEPP1 0.697 APOC1 APOE LUM MASP1 0.696 APOC1 MASP1 QSOX1 TNXB 0.696 COMP MASP1 PEPD SEPP1 0.696 APOC1 LUM MASP1 QSOX1 0.696 COMP GP1BA HIST2H2BE SEPP1 0.696 APOE LUM MASP1 SEPP1 0.695 GP1BA LUM QSOX1 TNXB 0.695 APOC1 APOE MASP1 SELL 0.695 GP1BA LUM MASP1 TNXB 0.694 HIST2H2BE LUM MASP1 SEPP1 0.694 APOC1 LUM MASP1 PEPD 0.693 GP1BA LUM SEPP1 TNXB 0.693 APOE COMP SEPP1 TNXB 0.692 APOC1 LUM PEPD TNXB 0.692 APOE COMP MASP1 QSOX1 0.692 COMP GP1BA LUM TNXB 0.692 APOC1 HIST2H2BE LUM MASP1 0.692 APOC1 HIST2H2BE LUM TNXB 0.691 APOE COMP MASP1 PEPD 0.691 COMP HIST2H2BE MASP1 QSOX1 0.691 COMP MASP1 QSOX1 SEPP1 0.691 APOC1 LUM MASP1 SEPP1 0.691 APOE COMP LUM MASP1 0.690 LUM PEPD QSOX1 TNXB 0.690 LUM QSOX1 SEPP1 TNXB 0.690 APOE LUM PEPD TNXB 0.690 APOE COMP GP1BA HIST2H2BE 0.689 LUM PEPD SEPP1 TNXB 0.689 APOE COMP HIST2H2BE PEPD 0.688 APOC1 GP1BA HIST2H2BE LUM 0.688 APOC1 LUM QSOX1 TNXB 0.688 COMP QSOX1 SEPP1 TNXB 0.688 APOC1 GP1BA LUM TNXB 0.688 APOE COMP HIST2H2BE LUM 0.688 APOC1 LUM QSOX1 SEPP1 0.688 COMP HIST2H2BE PEPD SEPP1 0.687 APOE COMP QSOX1 TNXB 0.687 APOE COMP LUM TNXB 0.687 APOC1 GP1BA LUM QSOX1 0.687 APOE COMP GP1BA SEPP1 0.687 APOE COMP GP1BA PEPD 0.687 COMP HIST2H2BE QSOX1 TNXB 0.686 HIST2H2BE LUM QSOX1 TNXB 0.686 HIST2H2BE LUM PEPD TNXB 0.686 COMP GP1BA PEPD SEPP1 0.686 APOC1 HIST2H2BE LUM QSOX1 0.686 APOE LUM MASP1 PEPD 0.686 APOE GP1BA LUM PEPD 0.686 APOE GP1BA LUM MASP1 0.686 APOE COMP HIST2H2BE SEPP1 0.686 APOC1 GP1BA LUM PEPD 0.686 MASP1 QSOX1 SEPP1 TNXB 0.686 APOE HIST2H2BE LUM TNXB 0.686 COMP LUM SEPP1 TNXB 0.685 COMP LUM PEPD TNXB 0.685 HIST2H2BE LUM SEPP1 TNXB 0.685 APOC1 HIST2H2BE LUM PEPD 0.684 COMP HIST2H2BE MASP1 PEPD 0.684 APOE COMP PEPD SEPP1 0.684 COMP GP1BA QSOX1 TNXB 0.684 APOE COMP GP1BA LUM 0.683 APOC1 MASP1 QSOX1 SEPP1 0.683 APOC1 LUM PEPD QSOX1 0.683 APOC1 LUM PEPD SEPP1 0.683 APOE HIST2H2BE MASP1 SELL 0.683 APOC1 LUM SEPP1 TNXB 0.683 COMP HIST2H2BE LUM QSOX1 0.683 APOE COMP GP1BA QSOX1 0.682 GP1BA LUM PEPD SEPP1 0.682 COMP LUM QSOX1 TNXB 0.682 COMP LUM QSOX1 SEPP1 0.682 APOE HIST2H2BE LUM MASP1 0.682 APOE COMP QSOX1 SEPP1 0.682 COMP HIST2H2BE LUM MASP1 0.682 APOE LUM QSOX1 TNXB 0.681 APOC1 APOE GP1BA LUM 0.681 COMP GP1BA QSOX1 SEPP1 0.681 COMP HIST2H2BE LUM PEPD 0.681 APOC1 APOE LUM QSOX1 0.680 APOC1 APOE LUM PEPD 0.680 APOC1 HIST2H2BE LUM SEPP1 0.680 COMP GP1BA HIST2H2BE PEPD 0.680 COMP GP1BA HIST2H2BE QSOX1 0.679 APOE COMP LUM PEPD 0.679 COMP GP1BA LUM SEPP1 0.679 APOC1 APOE LUM TNXB 0.679 GP1BA LUM QSOX1 SEPP1 0.678 HIST2H2BE LUM QSOX1 SEPP1 0.678 COMP PEPD QSOX1 TNXB 0.678 APOC1 HIST2H2BE QSOX1 TNXB 0.678 MASP1 PEPD SEPP1 TNXB 0.678 GP1BA HIST2H2BE LUM SEPP1 0.678 APOC1 APOE HIST2H2BE LUM 0.677 HIST2H2BE LUM PEPD SEPP1 0.677 GP1BA MASP1 PEPD TNXB 0.677 COMP HIST2H2BE PEPD QSOX1 0.677 APOE LUM SEPP1 TNXB 0.676 APOE LUM MASP1 QSOX1 0.676 APOC1 MASP1 SEPP1 TNXB 0.676 COMP GP1BA HIST2H2BE MASP1 0.676 COMP GP1BA LUM MASP1 0.676 COMP GP1BA LUM PEPD 0.675 LUM PEPD QSOX1 SEPP1 0.675 APOE COMP PEPD QSOX1 0.675 COMP GP1BA MASP1 PEPD 0.675 APOC1 GP1BA LUM SEPP1 0.674 APOC1 GP1BA QSOX1 TNXB 0.674 COMP LUM MASP1 PEPD 0.674 APOE COMP HIST2H2BE QSOX1 0.674 COMP GP1BA HIST2H2BE LUM 0.673 APOE COMP LUM SEPP1 0.673 COMP LUM PEPD SEPP1 0.673 APOC1 APOE MASP1 QSOX1 0.673 GP1BA HIST2H2BE LUM PEPD 0.673 APOE GP1BA LUM SEPP1 0.672 APOE GP1BA LUM QSOX1 0.672 APOC1 GP1BA LUM MASP1 0.672 HIST2H2BE MASP1 SEPP1 TNXB 0.671 APOE LUM PEPD QSOX1 0.671 APOE COMP LUM QSOX1 0.671 GP1BA LUM MASP1 PEPD 0.671 GP1BA HIST2H2BE PEPD TNXB 0.671 APOC1 MASP1 PEPD TNXB 0.671 APOC1 HIST2H2BE MASP1 SELL 0.670 GP1BA PEPD SEPP1 TNXB 0.670 GP1BA MASP1 SEPP1 TNXB 0.670 APOE HIST2H2BE LUM SEPP1 0.670 COMP PEPD QSOX1 SEPP1 0.670 APOC1 APOE LUM SEPP1 0.669 APOE HIST2H2BE LUM PEPD 0.669 APOE MASP1 QSOX1 TNXB 0.669 GP1BA LUM PEPD QSOX1 0.669 APOE GP1BA HIST2H2BE LUM 0.668 GP1BA PEPD QSOX1 TNXB 0.668 APOE MASP1 SEPP1 TNXB 0.668 GP1BA MASP1 QSOX1 TNXB 0.668 APOE LUM PEPD SEPP1 0.668 MASP1 PEPD QSOX1 TNXB 0.668 GP1BA MASP1 QSOX1 SEPP1 0.668 APOE HIST2H2BE LUM QSOX1 0.667 APOC1 HIST2H2BE MASP1 QSOX1 0.667 GP1BA HIST2H2BE QSOX1 TNXB 0.667 APOC1 GP1BA PEPD TNXB 0.666 COMP GP1BA MASP1 QSOX1 0.666 APOE MASP1 PEPD TNXB 0.666 HIST2H2BE QSOX1 SEPP1 TNXB 0.666 APOC1 PEPD QSOX1 TNXB 0.665 HIST2H2BE MASP1 QSOX1 TNXB 0.665 APOC1 GP1BA HIST2H2BE QSOX1 0.665 GP1BA QSOX1 SEPP1 TNXB 0.665 APOC1 APOE MASP1 TNXB 0.664 LUM MASP1 PEPD QSOX1 0.664 HIST2H2BE LUM MASP1 PEPD 0.664 APOC1 APOE HIST2H2BE SELL 0.664 HIST2H2BE MASP1 QSOX1 SEPP1 0.664 APOC1 QSOX1 SEPP1 TNXB 0.663 APOE LUM QSOX1 SEPP1 0.663 APOC1 MASP1 PEPD QSOX1 0.663 COMP GP1BA PEPD QSOX1 0.663 HIST2H2BE LUM PEPD QSOX1 0.663 APOC1 HIST2H2BE MASP1 TNXB 0.663 APOC1 GP1BA MASP1 QSOX1 0.663 COMP GP1BA LUM QSOX1 0.662 GP1BA HIST2H2BE SEPP1 TNXB 0.662 GP1BA HIST2H2BE LUM QSOX1 0.662 APOE GP1BA MASP1 SELL 0.661 COMP LUM PEPD QSOX1 0.661 COMP LUM MASP1 QSOX1 0.661 APOC1 APOE QSOX1 TNXB 0.661 APOE GP1BA QSOX1 TNXB 0.660 APOE GP1BA PEPD TNXB 0.659 HIST2H2BE LUM MASP1 QSOX1 0.659 APOC1 MASP1 PEPD SEPP1 0.659 APOC1 GP1BA MASP1 SELL 0.659 HIST2H2BE MASP1 PEPD TNXB 0.658 GP1BA MASP1 PEPD SEPP1 0.658 GP1BA LUM MASP1 QSOX1 0.658 APOC1 APOE GP1BA QSOX1 0.657 HIST2H2BE PEPD QSOX1 TNXB 0.656 COMP MASP1 PEPD QSOX1 0.656 APOC1 APOE GP1BA SELL 0.656 PEPD QSOX1 SEPP1 TNXB 0.654 APOC1 GP1BA HIST2H2BE TNXB 0.654 APOC1 APOE GP1BA TNXB 0.653 APOE HIST2H2BE MASP1 TNXB 0.652 APOC1 PEPD SEPP1 TNXB 0.651 APOE HIST2H2BE QSOX1 TNXB 0.649 APOC1 GP1BA QSOX1 SEPP1 0.649 APOC1 APOE PEPD TNXB 0.648 APOC1 HIST2H2BE PEPD TNXB 0.648 GP1BA HIST2H2BE LUM MASP1 0.648 APOC1 GP1BA MASP1 TNXB 0.648 HIST2H2BE PEPD SEPP1 TNXB 0.647 APOC1 GP1BA PEPD QSOX1 0.646 APOE GP1BA HIST2H2BE TNXB 0.646 MASP1 PEPD QSOX1 SEPP1 0.645 APOC1 GP1BA SEPP1 TNXB 0.645 APOC1 GP1BA HIST2H2BE PEPD 0.644 GP1BA HIST2H2BE QSOX1 SEPP1 0.643 APOE MASP1 PEPD SEPP1 0.643 APOE GP1BA MASP1 TNXB 0.643 APOC1 PEPD QSOX1 SEPP1 0.643 APOC1 APOE HIST2H2BE TNXB 0.643 APOC1 GP1BA MASP1 PEPD 0.643 APOE PEPD QSOX1 TNXB 0.643 APOE MASP1 QSOX1 SEPP1 0.643 APOE GP1BA SEPP1 TNXB 0.641 APOC1 HIST2H2BE QSOX1 SEPP1 0.640 APOC1 HIST2H2BE SEPP1 TNXB 0.638 HIST2H2BE MASP1 PEPD SEPP1 0.638 APOC1 GP1BA PEPD SEPP1 0.638 APOC1 HIST2H2BE MASP1 SEPP1 0.637 APOC1 APOE PEPD QSOX1 0.637 GP1BA HIST2H2BE MASP1 SEPP1 0.636 APOC1 HIST2H2BE PEPD QSOX1 0.635 APOC1 APOE SEPP1 TNXB 0.634 APOC1 APOE HIST2H2BE QSOX1 0.634 APOC1 GP1BA MASP1 SEPP1 0.634 APOE QSOX1 SEPP1 TNXB 0.633 GP1BA HIST2H2BE MASP1 SELL 0.633 APOC1 APOE QSOX1 SEPP1 0.633 GP1BA PEPD QSOX1 SEPP1 0.632 APOE HIST2H2BE PEPD TNXB 0.632 APOC1 GP1BA HIST2H2BE SELL 0.632 APOE HIST2H2BE SEPP1 TNXB 0.631 APOC1 APOE GP1BA PEPD 0.631 GP1BA HIST2H2BE MASP1 TNXB 0.629 APOC1 APOE MASP1 SEPP1 0.628 GP1BA HIST2H2BE PEPD SEPP1 0.627 APOE GP1BA QSOX1 SEPP1 0.627 APOE HIST2H2BE MASP1 SEPP1 0.626 APOE PEPD SEPP1 TNXB 0.625 APOE GP1BA MASP1 SEPP1 0.624 APOC1 APOE MASP1 PEPD 0.619 APOE GP1BA HIST2H2BE SELL 0.618 APOC1 GP1BA HIST2H2BE SEPP1 0.617 HIST2H2BE PEPD QSOX1 SEPP1 0.616 APOC1 HIST2H2BE MASP1 PEPD 0.614 GP1BA MASP1 PEPD QSOX1 0.613 APOE HIST2H2BE QSOX1 SEPP1 0.611 APOE GP1BA PEPD SEPP1 0.611 APOC1 HIST2H2BE PEPD SEPP1 0.609 GP1BA HIST2H2BE PEPD QSOX1 0.604 APOE GP1BA PEPD QSOX1 0.603 APOE GP1BA MASP1 QSOX1 0.603 APOC1 APOE GP1BA SEPP1 0.603 APOE MASP1 PEPD QSOX1 0.603 APOE PEPD QSOX1 SEPP1 0.599 APOE GP1BA HIST2H2BE SEPP1 0.598 APOE GP1BA MASP1 PEPD 0.597 APOC1 APOE PEPD SEPP1 0.596 APOE HIST2H2BE MASP1 QSOX1 0.595 HIST2H2BE MASP1 PEPD QSOX1 0.592 APOC1 APOE HIST2H2BE SEPP1 0.588 APOE GP1BA HIST2H2BE QSOX1 0.588 GP1BA HIST2H2BE MASP1 PEPD 0.584 APOC1 APOE HIST2H2BE PEPD 0.584 APOC1 APOE GP1BA HIST2H2BE 0.582 APOE GP1BA HIST2H2BE PEPD 0.581 GP1BA HIST2H2BE MASP1 QSOX1 0.581 APOE HIST2H2BE PEPD QSOX1 0.581 APOC1 APOE GP1BA MASP1 0.579 APOC1 APOE HIST2H2BE MASP1 0.576 APOE HIST2H2BE PEPD SEPP1 0.574 APOE HIST2H2BE MASP1 PEPD 0.559

TABLE 9 HIV+ panels Individual Candidate Biomarkers protein.1 AUC PGLYRP2 0.770 IGFBP6 0.766 SEPP1 0.704 TAGLN2 0.692 APOA1 0.681 CPN2 0.678 PFN1 0.672 APOA4 0.671 VASN 0.656 CD14 0.625 CD163 0.604 TLN1 0.599 VCAM1 0.595 CLU 0.592 S100A8 0.531 MST1 0.505 S100A9 0.463

TABLE 10 HIV+ panels Combination of Two Candidate Biomarkers protein.1 protein.2 AUC CPN2 MST1 0.860 VASN VCAM1 0.817 IGFBP6 PGLYRP2 0.816 PFN1 S100A8 0.803 PGLYRP2 TAGLN2 0.791 PFN1 PGLYRP2 0.790 CD14 CPN2 0.786 PGLYRP2 VASN 0.775 MST1 PGLYRP2 0.772 S100A8 S100A9 0.771 IGFBP6 TAGLN2 0.768 PFN1 S100A9 0.767 CD163 VASN 0.762 CD14 PFN1 0.760 CD14 PGLYRP2 0.758 IGFBP6 PFN1 0.752 CPN2 PGLYRP2 0.750 PGLYRP2 VCAM1 0.746 S100A8 TAGLN2 0.745 CPN2 IGFBP6 0.745 APOA1 PGLYRP2 0.743 PGLYRP2 SEPP1 0.742 CD163 PGLYRP2 0.742 PFN1 SEPP1 0.738 CD14 TAGLN2 0.738 SEPP1 TAGLN2 0.736 PGLYRP2 TLN1 0.735 APOA4 TAGLN2 0.735 APOA4 PGLYRP2 0.733 CD14 VASN 0.730 S100A9 TAGLN2 0.730 CD14 CLU 0.729 IGFBP6 MST1 0.729 IGFBP6 S100A8 0.728 CPN2 TLN1 0.725 CLU MST1 0.721 CD14 IGFBP6 0.720 SEPP1 TLN1 0.717 IGFBP6 S100A9 0.713 APOA4 PFN1 0.713 APOA1 MST1 0.709 IGFBP6 VASN 0.709 CD163 SEPP1 0.709 APOA1 PFN1 0.708 PGLYRP2 S100A9 0.703 APOA1 IGFBP6 0.703 APOA1 TAGLN2 0.702 CD163 IGFBP6 0.702 CD163 CPN2 0.699 APOA4 TLN1 0.699 APOA4 MST1 0.699 IGFBP6 SEPP1 0.698 MST1 SEPP1 0.697 MST1 VASN 0.696 CLU PGLYRP2 0.695 APOA4 CD14 0.692 IGFBP6 VCAM1 0.691 PGLYRP2 S100A8 0.688 CPN2 VCAM1 0.688 IGFBP6 TLN1 0.688 APOA1 CD163 0.687 APOA4 IGFBP6 0.685 CLU IGFBP6 0.684 MST1 TAGLN2 0.678 CD14 SEPP1 0.677 SEPP1 VCAM1 0.676 TAGLN2 VASN 0.674 APOA4 CD163 0.673 MST1 PFN1 0.673 APOA1 CD14 0.672 CPN2 PFN1 0.670 PFN1 VASN 0.670 APOA4 VCAM1 0.667 CPN2 SEPP1 0.666 CPN2 TAGLN2 0.666 TAGLN2 VCAM1 0.663 CLU PFN1 0.661 CD163 TAGLN2 0.657 TLN1 VASN 0.656 CD163 PFN1 0.655 PFN1 VCAM1 0.655 CLU TAGLN2 0.655 APOA1 TLN1 0.653 CD163 TLN1 0.653 CLU TLN1 0.650 APOA1 CPN2 0.649 CPN2 S100A8 0.649 APOA1 SEPP1 0.647 CLU VCAM1 0.646 S100A8 TLN1 0.645 SEPP1 VASN 0.644 CD163 CLU 0.644 APOA4 CPN2 0.641 APOA1 VASN 0.637 CLU SEPP1 0.632 APOA1 VCAM1 0.631 CPN2 S100A9 0.630 S100A8 VASN 0.629 APOA4 SEPP1 0.629 CPN2 VASN 0.624 CD14 TLN1 0.623 APOA4 VASN 0.618 TLN1 VCAM1 0.617 S100A8 SEPP1 0.616 S100A9 VASN 0.615 S100A9 SEPP1 0.613 APOA4 S100A8 0.608 APOA1 S100A8 0.607 S100A9 TLN1 0.606 PFN1 TAGLN2 0.602 APOA1 S100A9 0.598 CD14 VCAM1 0.597 APOA4 CLU 0.596 APOA4 S100A9 0.596 CD14 CD163 0.592 APOA1 APOA4 0.583 APOA1 CLU 0.581 TAGLN2 TLN1 0.580 CLU VASN 0.579 PFN1 TLN1 0.565 S100A8 VCAM1 0.563 CLU S100A8 0.562 CLU CPN2 0.552 CD14 S100A8 0.550 CD163 S100A8 0.549 CD163 MST1 0.547 CD14 S100A9 0.545 CD14 MST1 0.541 MST1 VCAM1 0.538 MST1 S100A8 0.538 MST1 TLN1 0.538 CD163 VCAM1 0.533 CLU S100A9 0.530 S100A9 VCAM1 0.527 CD163 S100A9 0.517 MST1 S100A9 0.489

TABLE 11 HIV+ panels Combination of Three Candidate Biomarkers protein.1 protein.2 protein.3 AUC APOA1 CPN2 MST1 1.000 CD163 S100A8 S100A9 1.000 CD163 TAGLN2 VASN 1.000 S100A8 S100A9 VCAM1 1.000 CPN2 MST1 SEPP1 1.000 CD163 TLN1 VASN 1.000 CD14 CPN2 PFN1 1.000 CD163 PFN1 VASN 1.000 CD14 CLU PFN1 1.000 PFN1 S100A8 SEPP1 1.000 CPN2 IGFBP6 MST1 1.000 CD14 CPN2 MST1 0.999 CPN2 MST1 PGLYRP2 0.999 CD14 CLU TAGLN2 0.999 CPN2 MST1 PFN1 0.999 CD14 CPN2 TAGLN2 0.999 PFN1 S100A9 SEPP1 0.999 CD14 PFN1 S100A8 0.996 CPN2 MST1 TLN1 0.972 IGFBP6 PFN1 S100A8 0.938 CPN2 MST1 VCAM1 0.920 CPN2 MST1 S100A8 0.919 PFN1 S100A8 VCAM1 0.912 PGLYRP2 TAGLN2 VCAM1 0.909 CD14 PFN1 PGLYRP2 0.906 CPN2 MST1 S100A9 0.903 CD14 CPN2 IGFBP6 0.899 CD14 PGLYRP2 TAGLN2 0.899 CPN2 IGFBP6 TLN1 0.899 IGFBP6 PFN1 S100A9 0.896 PFN1 PGLYRP2 S100A8 0.894 CD14 CPN2 TLN1 0.894 CD163 MST1 VASN 0.892 PFN1 PGLYRP2 VCAM1 0.889 APOA4 CPN2 MST1 0.889 APOA1 CD163 PFN1 0.887 CPN2 MST1 TAGLN2 0.886 PFN1 S100A8 S100A9 0.878 MST1 PFN1 S100A8 0.871 CD14 CLU TLN1 0.870 CD14 CPN2 S100A9 0.869 CD163 CPN2 TLN1 0.865 CD163 PFN1 S100A8 0.863 PFN1 S100A8 TAGLN2 0.862 MST1 PFN1 PGLYRP2 0.858 MST1 PGLYRP2 TAGLN2 0.858 CD163 IGFBP6 VASN 0.856 CD163 CPN2 MST1 0.856 CD14 TAGLN2 VASN 0.854 PGLYRP2 TAGLN2 VASN 0.852 TAGLN2 VASN VCAM1 0.849 PFN1 PGLYRP2 VASN 0.848 APOA1 CD14 PFN1 0.843 S100A8 S100A9 TAGLN2 0.842 APOA1 PFN1 S100A8 0.839 IGFBP6 PFN1 PGLYRP2 0.838 CPN2 PGLYRP2 TLN1 0.837 APOA4 CD14 PFN1 0.837 CD163 CLU TLN1 0.837 PFN1 VASN VCAM1 0.836 IGFBP6 PGLYRP2 TAGLN2 0.836 CD163 PFN1 PGLYRP2 0.836 CD14 CD163 CPN2 0.835 MST1 VASN VCAM1 0.833 CD14 PFN1 S100A9 0.833 CD14 CD163 VASN 0.833 CPN2 MST1 VASN 0.832 APOA1 PFN1 S100A9 0.831 CD14 IGFBP6 TAGLN2 0.830 APOA1 CD163 TAGLN2 0.829 CD14 CPN2 VASN 0.827 APOA4 PFN1 S100A8 0.826 CD163 PGLYRP2 VASN 0.826 CD163 CPN2 IGFBP6 0.825 CLU CPN2 MST1 0.823 IGFBP6 S100A8 TAGLN2 0.823 PFN1 S100A8 VASN 0.822 IGFBP6 VASN VCAM1 0.822 PFN1 S100A9 VCAM1 0.822 CPN2 PFN1 PGLYRP2 0.821 APOA1 CD14 TAGLN2 0.820 MST1 PFN1 S100A9 0.817 CD14 IGFBP6 PFN1 0.817 PGLYRP2 VASN VCAM1 0.817 PFN1 PGLYRP2 S100A9 0.816 CD14 CPN2 PGLYRP2 0.815 PFN1 S100A9 VASN 0.813 S100A8 TAGLN2 VCAM1 0.812 IGFBP6 S100A9 TAGLN2 0.812 PGLYRP2 S100A8 S100A9 0.811 CD163 SEPP1 TAGLN2 0.811 MST1 S100A8 TAGLN2 0.810 S100A8 SEPP1 TAGLN2 0.810 APOA1 S100A8 S100A9 0.809 CD14 CPN2 VCAM1 0.809 APOA4 CD14 TAGLN2 0.809 APOA4 PFN1 S100A9 0.809 IGFBP6 S100A8 S100A9 0.808 CPN2 PGLYRP2 TAGLN2 0.808 S100A9 SEPP1 TAGLN2 0.808 CPN2 IGFBP6 PGLYRP2 0.806 CPN2 PFN1 S100A8 0.805 CD163 PGLYRP2 TAGLN2 0.804 CPN2 PFN1 S100A9 0.803 CD14 S100A8 TAGLN2 0.797 PFN1 S100A9 TAGLN2 0.794 CD14 PFN1 SEPP1 0.793 CD163 CLU MST1 0.793 APOA4 CD14 CPN2 0.792 MST1 PFN1 SEPP1 0.792 CPN2 IGFBP6 VCAM1 0.791 CLU IGFBP6 MST1 0.790 CLU PFN1 S100A8 0.790 IGFBP6 PGLYRP2 VCAM1 0.790 PFN1 PGLYRP2 TAGLN2 0.790 CD163 PFN1 S100A9 0.789 CD14 VASN VCAM1 0.789 CD14 PFN1 VASN 0.789 APOA4 TAGLN2 VCAM1 0.788 CLU MST1 PGLYRP2 0.787 CPN2 IGFBP6 S100A9 0.787 CPN2 IGFBP6 S100A8 0.786 MST1 S100A8 S100A9 0.782 CD14 CPN2 S100A8 0.782 CD163 PFN1 SEPP1 0.781 CLU MST1 VCAM1 0.780 MST1 S100A9 TAGLN2 0.779 S100A9 TAGLN2 VCAM1 0.779 PFN1 PGLYRP2 SEPP1 0.778 CD14 SEPP1 TAGLN2 0.777 PGLYRP2 TLN1 VCAM1 0.774 APOA4 CD163 PFN1 0.774 CD163 IGFBP6 PGLYRP2 0.772 APOA1 IGFBP6 PGLYRP2 0.772 CD14 IGFBP6 PGLYRP2 0.772 S100A8 S100A9 TLN1 0.772 CPN2 PFN1 VCAM1 0.772 CD14 CLU MST1 0.771 CPN2 PGLYRP2 VASN 0.771 CD14 PGLYRP2 TLN1 0.771 IGFBP6 MST1 PGLYRP2 0.771 APOA1 PFN1 PGLYRP2 0.771 PFN1 PGLYRP2 TLN1 0.771 IGFBP6 PGLYRP2 TLN1 0.769 CPN2 S100A8 TAGLN2 0.769 PGLYRP2 SEPP1 TAGLN2 0.769 APOA4 CD163 TAGLN2 0.768 APOA4 PGLYRP2 TAGLN2 0.768 IGFBP6 PGLYRP2 SEPP1 0.767 IGFBP6 PGLYRP2 VASN 0.767 CD14 CLU IGFBP6 0.767 CD14 PGLYRP2 VASN 0.766 S100A8 S100A9 SEPP1 0.766 APOA4 CD163 TLN1 0.766 CD163 CPN2 PGLYRP2 0.766 APOA4 S100A8 S100A9 0.765 MST1 PGLYRP2 VASN 0.765 CLU CPN2 PGLYRP2 0.765 CD163 MST1 PGLYRP2 0.765 CD163 VASN VCAM1 0.764 APOA4 PFN1 PGLYRP2 0.764 APOA4 CD14 TLN1 0.764 APOA4 IGFBP6 PGLYRP2 0.764 CD14 S100A8 S100A9 0.763 TLN1 VASN VCAM1 0.763 CLU PFN1 S100A9 0.763 CPN2 IGFBP6 TAGLN2 0.763 MST1 PFN1 VASN 0.763 CPN2 IGFBP6 PFN1 0.762 CLU MST1 TAGLN2 0.761 IGFBP6 MST1 VASN 0.760 CD163 S100A8 TAGLN2 0.759 CPN2 S100A8 S100A9 0.759 CD14 CPN2 SEPP1 0.759 PGLYRP2 TLN1 VASN 0.759 CLU PGLYRP2 TLN1 0.759 MST1 PGLYRP2 SEPP1 0.758 APOA1 MST1 PGLYRP2 0.758 APOA1 CD163 VASN 0.755 CPN2 PGLYRP2 VCAM1 0.754 IGFBP6 TAGLN2 VCAM1 0.754 IGFBP6 PGLYRP2 S100A9 0.754 CD14 CD163 CLU 0.753 APOA4 CPN2 TLN1 0.753 S100A8 VASN VCAM1 0.753 APOA4 IGFBP6 MST1 0.751 APOA1 CD14 PGLYRP2 0.751 CD14 S100A9 TAGLN2 0.751 CD14 CLU VASN 0.751 APOA1 PGLYRP2 TAGLN2 0.750 CLU PFN1 PGLYRP2 0.750 APOA4 PGLYRP2 TLN1 0.749 CD14 MST1 PGLYRP2 0.748 CD14 PGLYRP2 VCAM1 0.747 CPN2 PGLYRP2 SEPP1 0.746 CD163 SEPP1 TLN1 0.745 PGLYRP2 SEPP1 VASN 0.745 CD14 IGFBP6 VASN 0.745 APOA4 CPN2 PGLYRP2 0.744 MST1 SEPP1 TAGLN2 0.744 CLU MST1 PFN1 0.744 IGFBP6 PFN1 VCAM1 0.744 APOA4 MST1 PGLYRP2 0.743 MST1 TAGLN2 VASN 0.743 CD163 PGLYRP2 TLN1 0.743 PFN1 S100A8 TLN1 0.743 CD14 CD163 PGLYRP2 0.742 CD163 IGFBP6 TAGLN2 0.742 PGLYRP2 S100A9 TAGLN2 0.740 IGFBP6 TAGLN2 VASN 0.740 MST1 PGLYRP2 TLN1 0.740 CD14 PGLYRP2 SEPP1 0.740 S100A9 VASN VCAM1 0.740 APOA4 MST1 PFN1 0.739 APOA4 PFN1 VCAM1 0.739 CLU IGFBP6 PGLYRP2 0.739 IGFBP6 MST1 PFN1 0.739 CPN2 S100A9 TAGLN2 0.739 CLU PGLYRP2 TAGLN2 0.739 PGLYRP2 SEPP1 TLN1 0.738 IGFBP6 S100A8 TLN1 0.738 APOA1 PGLYRP2 VASN 0.737 CPN2 S100A8 TLN1 0.737 CD163 IGFBP6 PFN1 0.737 CLU MST1 TLN1 0.737 APOA1 CD14 CPN2 0.737 APOA4 VASN VCAM1 0.737 APOA4 MST1 TAGLN2 0.736 MST1 PGLYRP2 VCAM1 0.736 APOA4 S100A8 TAGLN2 0.736 CD14 CLU CPN2 0.736 APOA4 CD14 PGLYRP2 0.736 PGLYRP2 S100A8 TAGLN2 0.735 IGFBP6 MST1 TAGLN2 0.735 CPN2 TAGLN2 VCAM1 0.734 IGFBP6 PGLYRP2 S100A8 0.733 CD163 MST1 SEPP1 0.733 CLU MST1 VASN 0.732 APOA1 S100A8 TAGLN2 0.732 S100A8 TAGLN2 VASN 0.731 S100A8 S100A9 VASN 0.730 CPN2 IGFBP6 VASN 0.730 SEPP1 TAGLN2 VCAM1 0.730 CPN2 PGLYRP2 S100A8 0.729 CD163 SEPP1 VASN 0.729 S100A9 TAGLN2 VASN 0.729 CPN2 VASN VCAM1 0.729 APOA1 IGFBP6 MST1 0.728 CLU S100A8 S100A9 0.728 CD163 CPN2 VASN 0.728 MST1 PGLYRP2 S100A9 0.727 APOA4 CD14 IGFBP6 0.727 CD14 CD163 TAGLN2 0.727 PFN1 SEPP1 VCAM1 0.727 CPN2 TLN1 VCAM1 0.727 APOA1 CPN2 PGLYRP2 0.726 CD163 PGLYRP2 S100A9 0.726 APOA1 CPN2 IGFBP6 0.726 CD163 S100A9 TAGLN2 0.726 CLU VASN VCAM1 0.726 APOA1 CD14 TLN1 0.726 CD14 CLU VCAM1 0.726 APOA4 TLN1 VCAM1 0.725 CD14 CLU SEPP1 0.725 APOA4 S100A8 TLN1 0.725 CD163 S100A8 VASN 0.724 PGLYRP2 TAGLN2 TLN1 0.724 CD14 CLU PGLYRP2 0.724 CPN2 PGLYRP2 S100A9 0.724 CLU CPN2 IGFBP6 0.723 CD14 S100A9 VASN 0.722 CD163 PGLYRP2 SEPP1 0.722 CLU MST1 SEPP1 0.722 CLU IGFBP6 S100A8 0.721 CD163 CLU VASN 0.721 CLU PGLYRP2 VASN 0.721 APOA1 PGLYRP2 S100A8 0.721 APOA4 S100A9 TAGLN2 0.721 CD14 CD163 PFN1 0.720 IGFBP6 PFN1 TAGLN2 0.720 IGFBP6 SEPP1 TAGLN2 0.719 CLU IGFBP6 S100A9 0.719 CD14 SEPP1 VASN 0.719 APOA4 PGLYRP2 VASN 0.717 CPN2 IGFBP6 SEPP1 0.717 APOA4 IGFBP6 TLN1 0.717 APOA1 IGFBP6 TAGLN2 0.717 APOA1 PGLYRP2 S100A9 0.717 PGLYRP2 S100A9 VASN 0.717 CLU MST1 S100A8 0.716 APOA1 TAGLN2 VCAM1 0.716 PGLYRP2 S100A8 VASN 0.715 CD163 S100A9 VASN 0.715 SEPP1 VASN VCAM1 0.715 APOA4 CD163 VASN 0.715 APOA4 CD14 VASN 0.715 CLU IGFBP6 TAGLN2 0.714 CD14 SEPP1 TLN1 0.713 MST1 PGLYRP2 S100A8 0.713 IGFBP6 PFN1 SEPP1 0.713 CLU IGFBP6 VCAM1 0.713 PGLYRP2 SEPP1 VCAM1 0.713 APOA1 VASN VCAM1 0.712 APOA4 CPN2 IGFBP6 0.712 APOA1 IGFBP6 PFN1 0.712 APOA1 CD163 MST1 0.712 APOA1 CD163 TLN1 0.711 APOA4 S100A9 TLN1 0.710 PFN1 S100A9 TLN1 0.710 APOA1 CD163 IGFBP6 0.710 IGFBP6 S100A8 VCAM1 0.709 CLU IGFBP6 TLN1 0.709 CLU S100A9 TAGLN2 0.709 APOA1 CD163 PGLYRP2 0.709 CPN2 SEPP1 TLN1 0.709 APOA1 IGFBP6 S100A9 0.709 IGFBP6 MST1 S100A8 0.709 CD163 CLU IGFBP6 0.709 APOA1 S100A9 TAGLN2 0.708 CLU PGLYRP2 VCAM1 0.708 CD14 S100A8 VASN 0.708 CLU S100A8 TAGLN2 0.708 CD163 IGFBP6 S100A8 0.707 IGFBP6 S100A8 VASN 0.707 APOA1 IGFBP6 S100A8 0.706 IGFBP6 S100A8 SEPP1 0.706 CD14 MST1 TAGLN2 0.705 CLU TLN1 VCAM1 0.705 IGFBP6 PFN1 VASN 0.705 CD14 TLN1 VASN 0.705 CD14 PFN1 TAGLN2 0.705 IGFBP6 S100A9 VASN 0.705 APOA4 MST1 TLN1 0.704 IGFBP6 MST1 SEPP1 0.704 APOA4 SEPP1 TLN1 0.704 APOA1 CD14 IGFBP6 0.704 CLU PFN1 VCAM1 0.704 APOA4 CLU TLN1 0.704 CLU IGFBP6 PFN1 0.703 APOA1 CLU MST1 0.703 APOA4 PGLYRP2 VCAM1 0.703 CD14 MST1 PFN1 0.703 PFN1 SEPP1 TLN1 0.703 APOA1 MST1 TAGLN2 0.703 APOA1 PFN1 VCAM1 0.702 APOA1 PGLYRP2 SEPP1 0.702 APOA1 APOA4 PGLYRP2 0.702 APOA4 CD163 PGLYRP2 0.702 CD14 CLU S100A9 0.702 CD163 CLU PGLYRP2 0.702 APOA4 IGFBP6 TAGLN2 0.702 APOA4 CD14 CLU 0.701 APOA4 IGFBP6 PFN1 0.701 APOA1 MST1 PFN1 0.701 MST1 SEPP1 TLN1 0.700 CD14 TAGLN2 VCAM1 0.700 MST1 SEPP1 VASN 0.699 CD14 PGLYRP2 S100A9 0.699 IGFBP6 TLN1 VASN 0.699 APOA1 PGLYRP2 TLN1 0.699 CD14 IGFBP6 S100A8 0.699 CD163 IGFBP6 SEPP1 0.698 CLU MST1 S100A9 0.697 CLU TAGLN2 VCAM1 0.697 APOA4 IGFBP6 S100A8 0.696 PGLYRP2 S100A9 TLN1 0.696 PGLYRP2 S100A8 VCAM1 0.696 CD14 IGFBP6 SEPP1 0.696 APOA4 PGLYRP2 S100A8 0.696 APOA1 MST1 S100A8 0.695 APOA4 PGLYRP2 S100A9 0.695 SEPP1 TAGLN2 TLN1 0.695 PGLYRP2 S100A9 VCAM1 0.695 S100A8 SEPP1 TLN1 0.694 APOA4 TAGLN2 TLN1 0.694 CD14 MST1 VASN 0.694 CD163 CPN2 SEPP1 0.694 IGFBP6 SEPP1 VCAM1 0.694 CD163 PGLYRP2 S100A8 0.693 CPN2 S100A9 TLN1 0.693 CD14 PFN1 VCAM1 0.693 CD163 PGLYRP2 VCAM1 0.693 IGFBP6 MST1 S100A9 0.693 MST1 S100A8 VASN 0.692 APOA4 PFN1 TLN1 0.692 IGFBP6 TAGLN2 TLN1 0.691 PGLYRP2 S100A8 TLN1 0.691 APOA1 CD163 CPN2 0.690 APOA1 CD14 CLU 0.689 APOA4 PGLYRP2 SEPP1 0.688 APOA4 IGFBP6 S100A9 0.687 SEPP1 TLN1 VCAM1 0.686 CD163 CPN2 PFN1 0.685 APOA4 IGFBP6 VCAM1 0.685 APOA1 PGLYRP2 VCAM1 0.684 CD14 IGFBP6 MST1 0.684 APOA4 MST1 SEPP1 0.683 CD14 PGLYRP2 S100A8 0.683 IGFBP6 SEPP1 TLN1 0.682 CD163 IGFBP6 MST1 0.682 CLU PGLYRP2 SEPP1 0.682 S100A9 SEPP1 TLN1 0.681 APOA1 CD14 VASN 0.681 PGLYRP2 S100A9 SEPP1 0.680 CD163 IGFBP6 TLN1 0.680 IGFBP6 S100A9 TLN1 0.680 APOA4 CD163 IGFBP6 0.680 IGFBP6 PFN1 TLN1 0.679 CD14 IGFBP6 TLN1 0.679 APOA4 CD163 CPN2 0.679 IGFBP6 S100A9 VCAM1 0.678 MST1 SEPP1 VCAM1 0.678 APOA1 MST1 VASN 0.678 MST1 S100A9 VASN 0.678 APOA4 CLU MST1 0.677 CD163 CPN2 TAGLN2 0.677 IGFBP6 TLN1 VCAM1 0.677 APOA4 TLN1 VASN 0.676 APOA4 MST1 VASN 0.676 CD14 CD163 SEPP1 0.676 CLU IGFBP6 VASN 0.675 CLU S100A8 TLN1 0.674 CD163 CLU PFN1 0.674 IGFBP6 MST1 VCAM1 0.674 S100A8 TAGLN2 TLN1 0.674 CPN2 S100A8 VCAM1 0.673 MST1 TLN1 VASN 0.673 APOA1 IGFBP6 VASN 0.673 CD14 CLU S100A8 0.673 APOA1 IGFBP6 VCAM1 0.672 CD14 PFN1 TLN1 0.672 S100A8 TLN1 VASN 0.672 MST1 S100A8 SEPP1 0.671 APOA1 MST1 SEPP1 0.671 APOA1 CD163 SEPP1 0.670 PGLYRP2 S100A8 SEPP1 0.670 CD14 IGFBP6 VCAM1 0.670 CPN2 PFN1 TLN1 0.669 CD14 CD163 IGFBP6 0.669 APOA4 CD163 MST1 0.668 APOA1 CPN2 TLN1 0.667 APOA4 CLU PGLYRP2 0.667 CLU PFN1 SEPP1 0.667 CD163 CPN2 S100A8 0.666 CD163 IGFBP6 S100A9 0.666 CPN2 SEPP1 TAGLN2 0.666 APOA4 MST1 VCAM1 0.665 APOA1 CLU PGLYRP2 0.665 APOA4 PFN1 SEPP1 0.665 CPN2 PFN1 SEPP1 0.664 CPN2 TAGLN2 TLN1 0.664 APOA4 CPN2 VCAM1 0.663 APOA4 CLU PFN1 0.663 APOA1 IGFBP6 TLN1 0.662 APOA4 CLU TAGLN2 0.662 APOA4 CD14 MST1 0.662 SEPP1 TLN1 VASN 0.661 CPN2 SEPP1 VCAM1 0.661 APOA1 APOA4 TLN1 0.661 IGFBP6 S100A9 SEPP1 0.661 APOA1 MST1 TLN1 0.661 CD163 CLU TAGLN2 0.660 APOA1 CLU IGFBP6 0.660 APOA1 PFN1 SEPP1 0.660 PFN1 SEPP1 TAGLN2 0.659 IGFBP6 MST1 TLN1 0.659 APOA1 CPN2 VCAM1 0.658 APOA4 SEPP1 TAGLN2 0.657 APOA1 CPN2 PFN1 0.657 CLU S100A9 TLN1 0.655 IGFBP6 SEPP1 VASN 0.655 CLU SEPP1 TLN1 0.655 CD14 TAGLN2 TLN1 0.654 CLU IGFBP6 SEPP1 0.654 APOA4 CD163 SEPP1 0.654 CLU PGLYRP2 S100A8 0.654 APOA1 PFN1 VASN 0.654 S100A8 TLN1 VCAM1 0.654 CLU SEPP1 TAGLN2 0.653 APOA4 CPN2 PFN1 0.652 CD163 S100A8 TLN1 0.652 MST1 S100A9 SEPP1 0.652 CD163 MST1 TAGLN2 0.651 APOA4 CLU IGFBP6 0.651 APOA1 SEPP1 VCAM1 0.651 CLU PGLYRP2 S100A9 0.651 CPN2 TLN1 VASN 0.651 SEPP1 TAGLN2 VASN 0.651 APOA1 SEPP1 TAGLN2 0.650 PFN1 SEPP1 VASN 0.650 APOA1 SEPP1 TLN1 0.650 CD163 CLU SEPP1 0.649 APOA1 MST1 S100A9 0.649 CD163 CPN2 S100A9 0.648 CD14 IGFBP6 S100A9 0.648 APOA4 TAGLN2 VASN 0.648 CPN2 S100A9 VCAM1 0.647 S100A9 TLN1 VASN 0.647 APOA1 CD14 MST1 0.646 APOA4 CPN2 TAGLN2 0.646 APOA1 PFN1 TAGLN2 0.646 APOA4 CD14 S100A9 0.645 CPN2 PFN1 TAGLN2 0.645 CD163 CPN2 VCAM1 0.644 CD163 MST1 PFN1 0.643 APOA1 IGFBP6 SEPP1 0.643 CD163 IGFBP6 VCAM1 0.642 APOA1 CD163 S100A8 0.642 APOA1 TLN1 VCAM1 0.642 APOA1 CD163 S100A9 0.641 APOA4 PFN1 VASN 0.640 APOA1 CPN2 TAGLN2 0.639 CD14 SEPP1 VCAM1 0.639 APOA1 CD14 CD163 0.638 CLU TAGLN2 TLN1 0.638 APOA4 CD14 S100A8 0.638 APOA1 APOA4 PFN1 0.638 MST1 PFN1 TAGLN2 0.638 APOA1 TAGLN2 VASN 0.637 APOA1 S100A8 TLN1 0.637 APOA4 IGFBP6 VASN 0.637 S100A9 TAGLN2 TLN1 0.636 APOA1 APOA4 MST1 0.636 CLU SEPP1 VCAM1 0.635 APOA4 CD163 CLU 0.635 APOA4 MST1 S100A8 0.633 APOA1 CD163 CLU 0.633 APOA1 CLU PFN1 0.633 APOA4 CD14 SEPP1 0.633 APOA1 PFN1 TLN1 0.632 APOA1 APOA4 IGFBP6 0.632 APOA1 TAGLN2 TLN1 0.632 APOA1 CD14 S100A9 0.632 APOA4 SEPP1 VCAM1 0.631 APOA4 PFN1 TAGLN2 0.631 MST1 TAGLN2 VCAM1 0.630 APOA4 CD163 S100A9 0.630 CLU TLN1 VASN 0.630 APOA1 CD14 SEPP1 0.629 APOA1 APOA4 TAGLN2 0.629 APOA4 CD14 VCAM1 0.627 APOA1 TLN1 VASN 0.627 APOA4 CD14 CD163 0.627 CD163 S100A8 SEPP1 0.626 APOA1 S100A9 TLN1 0.626 CD14 CD163 TLN1 0.625 APOA4 CD163 S100A8 0.625 CLU PFN1 VASN 0.624 CD163 SEPP1 VCAM1 0.624 CD14 S100A8 TLN1 0.623 CPN2 PFN1 VASN 0.622 CD163 S100A9 SEPP1 0.622 CD163 TAGLN2 TLN1 0.621 CD163 S100A9 TLN1 0.621 CLU S100A8 VCAM1 0.621 CPN2 S100A8 SEPP1 0.621 MST1 S100A8 TLN1 0.620 APOA4 CLU VCAM1 0.620 APOA4 MST1 S100A9 0.619 S100A9 TLN1 VCAM1 0.619 CPN2 TAGLN2 VASN 0.619 APOA4 IGFBP6 SEPP1 0.619 TAGLN2 TLN1 VASN 0.618 APOA1 CLU TAGLN2 0.618 CD14 MST1 SEPP1 0.618 APOA4 S100A9 VCAM1 0.618 CLU CPN2 VCAM1 0.617 CLU PFN1 TLN1 0.617 CPN2 S100A8 VASN 0.617 APOA1 APOA4 CD163 0.617 APOA4 S100A8 VCAM1 0.616 PFN1 TAGLN2 VASN 0.615 CLU CPN2 TLN1 0.614 APOA1 MST1 VCAM1 0.614 CD163 PFN1 TLN1 0.614 APOA1 CD14 S100A8 0.613 CPN2 S100A9 SEPP1 0.613 APOA1 SEPP1 VASN 0.612 CLU CPN2 PFN1 0.612 CLU TAGLN2 VASN 0.612 PFN1 TAGLN2 VCAM1 0.611 APOA1 CLU VCAM1 0.610 CD163 CLU CPN2 0.610 APOA1 CPN2 S100A8 0.610 CPN2 SEPP1 VASN 0.609 CD163 CLU VCAM1 0.608 PFN1 TLN1 VASN 0.608 APOA1 APOA4 CD14 0.608 MST1 PFN1 VCAM1 0.607 CPN2 S100A9 VASN 0.607 CD163 PFN1 TAGLN2 0.607 CD14 TLN1 VCAM1 0.605 S100A8 SEPP1 VASN 0.605 APOA4 CPN2 S100A8 0.604 CLU CPN2 TAGLN2 0.604 APOA1 CD14 VCAM1 0.604 APOA1 CD163 VCAM1 0.602 CD163 TAGLN2 VCAM1 0.602 APOA1 CLU TLN1 0.602 APOA1 S100A8 VASN 0.600 CLU PFN1 TAGLN2 0.600 CLU S100A9 VCAM1 0.599 APOA1 CPN2 VASN 0.599 APOA4 CD163 VCAM1 0.599 APOA4 CPN2 VASN 0.599 CD14 S100A9 SEPP1 0.598 APOA1 CPN2 S100A9 0.598 APOA4 CPN2 SEPP1 0.598 CD163 TLN1 VCAM1 0.598 CD163 CLU S100A8 0.598 CD14 S100A8 SEPP1 0.597 MST1 PFN1 TLN1 0.595 S100A8 SEPP1 VCAM1 0.594 APOA4 S100A8 SEPP1 0.594 S100A9 SEPP1 VASN 0.594 CD163 PFN1 VCAM1 0.592 CLU CPN2 SEPP1 0.591 S100A9 SEPP1 VCAM1 0.590 APOA1 APOA4 VCAM1 0.588 TAGLN2 TLN1 VCAM1 0.588 APOA1 CPN2 SEPP1 0.588 APOA4 S100A8 VASN 0.587 APOA1 S100A9 VASN 0.586 PFN1 TLN1 VCAM1 0.586 APOA4 CPN2 S100A9 0.585 CD14 S100A9 TLN1 0.585 APOA1 S100A8 VCAM1 0.584 APOA1 CLU CPN2 0.583 CD163 CLU S100A9 0.579 APOA4 S100A9 SEPP1 0.579 APOA1 S100A8 SEPP1 0.577 APOA4 S100A9 VASN 0.576 APOA4 SEPP1 VASN 0.576 MST1 TAGLN2 TLN1 0.575 CLU SEPP1 VASN 0.575 CLU S100A8 VASN 0.575 CD163 MST1 TLN1 0.574 CLU S100A8 SEPP1 0.574 MST1 S100A9 TLN1 0.572 APOA4 CLU SEPP1 0.569 APOA1 S100A9 VCAM1 0.569 APOA1 APOA4 SEPP1 0.568 CLU S100A9 VASN 0.567 APOA1 S100A9 SEPP1 0.567 PFN1 TAGLN2 TLN1 0.565 APOA1 APOA4 CPN2 0.565 APOA1 APOA4 S100A8 0.564 APOA4 CLU S100A8 0.562 CLU S100A9 SEPP1 0.559 APOA1 APOA4 S100A9 0.557 CLU CPN2 S100A8 0.555 APOA1 CLU SEPP1 0.552 APOA1 APOA4 VASN 0.551 APOA4 CLU CPN2 0.551 APOA4 CLU S100A9 0.551 APOA4 CLU VASN 0.551 CD14 MST1 VCAM1 0.551 CD14 CD163 VCAM1 0.550 CLU CPN2 VASN 0.549 CD14 S100A8 VCAM1 0.547 CD14 S100A9 VCAM1 0.545 APOA1 CLU S100A8 0.542 APOA1 CLU VASN 0.542 CD14 CD163 MST1 0.540 CD14 MST1 TLN1 0.540 MST1 S100A8 VCAM1 0.539 CLU CPN2 S100A9 0.533 MST1 TLN1 VCAM1 0.531 CD14 CD163 S100A8 0.530 APOA1 CLU S100A9 0.530 CD163 MST1 S100A8 0.530 APOA1 APOA4 CLU 0.529 CD14 CD163 S100A9 0.524 CD163 S100A8 VCAM1 0.518 CD14 MST1 S100A8 0.517 MST1 S100A9 VCAM1 0.507 CD14 MST1 S100A9 0.502 CD163 MST1 S100A9 0.499 CD163 MST1 VCAM1 0.493 CD163 S100A9 VCAM1 0.491

TABLE 12 HIV+ panels Combination of Four Candidate Biomarkers protein.1 protein.2 protein.3 protein.4 AUC APOA1 APOA4 CPN2 MST1 1.000 APOA1 CD14 CLU PFN1 1.000 APOA1 CD14 CPN2 MST1 1.000 APOA1 CD163 CPN2 MST1 1.000 APOA1 CD163 PFN1 S100A8 1.000 APOA1 CD163 PFN1 VASN 1.000 APOA1 CD163 S100A8 S100A9 1.000 APOA1 CD163 TAGLN2 VASN 1.000 APOA1 CD163 TLN1 VASN 1.000 APOA1 CPN2 IGFBP6 MST1 1.000 APOA1 CPN2 MST1 PGLYRP2 1.000 APOA1 CPN2 MST1 S100A8 1.000 APOA1 CPN2 MST1 S100A9 1.000 APOA1 CPN2 MST1 VASN 1.000 APOA1 CPN2 MST1 VCAM1 1.000 APOA1 PFN1 S100A8 VCAM1 1.000 APOA1 S100A8 S100A9 VCAM1 1.000 APOA4 CD163 S100A8 S100A9 1.000 APOA4 CD163 TAGLN2 VASN 1.000 APOA4 CD163 TLN1 VASN 1.000 APOA4 CPN2 MST1 SEPP1 1.000 APOA4 PFN1 S100A8 SEPP1 1.000 APOA4 PFN1 S100A8 VCAM1 1.000 APOA4 S100A8 S100A9 VCAM1 1.000 CD14 CD163 CLU PFN1 1.000 CD14 CD163 CLU TAGLN2 1.000 CD14 CD163 CPN2 MST1 1.000 CD14 CD163 CPN2 PFN1 1.000 CD14 CD163 CPN2 TAGLN2 1.000 CD14 CD163 PFN1 VASN 1.000 CD14 CD163 S100A8 S100A9 1.000 CD14 CD163 TAGLN2 VASN 1.000 CD14 CD163 TLN1 VASN 1.000 CD14 CLU CPN2 MST1 1.000 CD14 CLU IGFBP6 PFN1 1.000 CD14 CLU MST1 PFN1 1.000 CD14 CLU PFN1 PGLYRP2 1.000 CD14 CLU PFN1 SEPP1 1.000 CD14 CLU PFN1 VCAM1 1.000 CD14 CLU TAGLN2 VCAM1 1.000 CD14 CPN2 IGFBP6 MST1 1.000 CD14 CPN2 IGFBP6 PFN1 1.000 CD14 CPN2 IGFBP6 S100A8 1.000 CD14 CPN2 IGFBP6 TAGLN2 1.000 CD14 CPN2 MST1 PFN1 1.000 CD14 CPN2 MST1 PGLYRP2 1.000 CD14 CPN2 MST1 TLN1 1.000 CD14 CPN2 PFN1 PGLYRP2 1.000 CD14 CPN2 PFN1 VCAM1 1.000 CD14 CPN2 TAGLN2 VCAM1 1.000 CD14 PFN1 S100A8 S100A9 1.000 CD14 PFN1 S100A8 TAGLN2 1.000 CD14 S100A8 S100A9 VCAM1 1.000 CD163 CLU MST1 VASN 1.000 CD163 CLU S100A8 S100A9 1.000 CD163 CLU TAGLN2 VASN 1.000 CD163 CLU TLN1 VASN 1.000 CD163 CPN2 IGFBP6 MST1 1.000 CD163 CPN2 IGFBP6 TLN1 1.000 CD163 CPN2 MST1 SEPP1 1.000 CD163 CPN2 MST1 TLN1 1.000 CD163 CPN2 MST1 VASN 1.000 CD163 CPN2 TAGLN2 VASN 1.000 CD163 CPN2 TLN1 VASN 1.000 CD163 IGFBP6 S100A8 S100A9 1.000 CD163 IGFBP6 TAGLN2 VASN 1.000 CD163 IGFBP6 TLN1 VASN 1.000 CD163 MST1 TAGLN2 VASN 1.000 CD163 MST1 TLN1 VASN 1.000 CD163 PFN1 S100A8 S100A9 1.000 CD163 PFN1 S100A8 SEPP1 1.000 CD163 PFN1 S100A8 VASN 1.000 CD163 PFN1 S100A9 SEPP1 1.000 CD163 PFN1 S100A9 VASN 1.000 CD163 PFN1 TAGLN2 VASN 1.000 CD163 PGLYRP2 S100A8 S100A9 1.000 CD163 PGLYRP2 TAGLN2 VASN 1.000 CD163 PGLYRP2 TLN1 VASN 1.000 CD163 S100A8 S100A9 SEPP1 1.000 CD163 S100A8 S100A9 TAGLN2 1.000 CD163 S100A8 S100A9 TLN1 1.000 CD163 S100A8 S100A9 VASN 1.000 CD163 S100A8 S100A9 VCAM1 1.000 CD163 S100A9 TAGLN2 VASN 1.000 CD163 S100A9 TLN1 VASN 1.000 CD163 SEPP1 TAGLN2 VASN 1.000 CD163 SEPP1 TLN1 VASN 1.000 CD163 TAGLN2 TLN1 VASN 1.000 CD163 TAGLN2 VASN VCAM1 1.000 CLU CPN2 MST1 SEPP1 1.000 CLU PFN1 S100A8 VCAM1 1.000 CLU S100A8 S100A9 VCAM1 1.000 CPN2 IGFBP6 MST1 PFN1 1.000 CPN2 IGFBP6 MST1 PGLYRP2 1.000 CPN2 IGFBP6 MST1 S100A9 1.000 CPN2 IGFBP6 MST1 VCAM1 1.000 CPN2 IGFBP6 PFN1 S100A8 1.000 CPN2 MST1 PFN1 SEPP1 1.000 CPN2 MST1 PGLYRP2 SEPP1 1.000 CPN2 MST1 PGLYRP2 VASN 1.000 CPN2 MST1 PGLYRP2 VCAM1 1.000 CPN2 MST1 S100A8 VCAM1 1.000 CPN2 MST1 S100A9 SEPP1 1.000 CPN2 MST1 SEPP1 TAGLN2 1.000 CPN2 MST1 SEPP1 VASN 1.000 CPN2 MST1 SEPP1 VCAM1 1.000 CPN2 MST1 TAGLN2 VCAM1 1.000 CPN2 MST1 TLN1 VCAM1 1.000 CPN2 MST1 VASN VCAM1 1.000 CPN2 PFN1 S100A8 VCAM1 1.000 CPN2 S100A8 S100A9 VCAM1 1.000 IGFBP6 PFN1 S100A8 VCAM1 1.000 IGFBP6 S100A8 S100A9 VCAM1 1.000 IGFBP6 TAGLN2 VASN VCAM1 1.000 MST1 S100A8 S100A9 TAGLN2 1.000 MST1 S100A8 S100A9 VCAM1 1.000 PFN1 S100A8 S100A9 VCAM1 1.000 PFN1 S100A8 SEPP1 VCAM1 1.000 PFN1 S100A8 TAGLN2 VCAM1 1.000 PFN1 S100A8 VASN VCAM1 1.000 PFN1 S100A9 SEPP1 VCAM1 1.000 PFN1 S100A9 VASN VCAM1 1.000 PGLYRP2 S100A8 S100A9 VCAM1 1.000 PGLYRP2 TAGLN2 VASN VCAM1 1.000 S100A8 S100A9 SEPP1 VCAM1 1.000 S100A8 S100A9 TAGLN2 VCAM1 1.000 S100A8 S100A9 TLN1 VCAM1 1.000 S100A8 S100A9 VASN VCAM1 1.000 S100A8 SEPP1 TAGLN2 VCAM1 1.000 S100A8 TAGLN2 VASN VCAM1 1.000 S100A9 TAGLN2 VASN VCAM1 1.000 APOA1 CD163 PFN1 S100A9 1.000 APOA1 CPN2 MST1 PFN1 1.000 APOA1 CPN2 MST1 TAGLN2 1.000 APOA4 CPN2 MST1 VCAM1 1.000 CD163 TLN1 VASN VCAM1 1.000 CLU CPN2 MST1 PGLYRP2 1.000 CPN2 IGFBP6 MST1 TAGLN2 1.000 APOA1 CLU CPN2 MST1 1.000 CD163 S100A8 SEPP1 TAGLN2 1.000 CD163 IGFBP6 PFN1 S100A8 1.000 CPN2 TAGLN2 VASN VCAM1 1.000 CD163 CPN2 MST1 PGLYRP2 1.000 CD163 S100A8 TLN1 VASN 1.000 CPN2 IGFBP6 MST1 S100A8 1.000 CD14 CPN2 MST1 VASN 1.000 APOA1 CPN2 MST1 SEPP1 1.000 PFN1 PGLYRP2 S100A8 S100A9 1.000 CD163 MST1 PFN1 VASN 1.000 CD163 PFN1 PGLYRP2 VASN 1.000 PFN1 PGLYRP2 VASN VCAM1 1.000 CD14 IGFBP6 PFN1 S100A8 1.000 CPN2 PFN1 S100A8 SEPP1 1.000 CD163 IGFBP6 PFN1 VASN 1.000 APOA1 CPN2 MST1 TLN1 1.000 CPN2 MST1 S100A9 VCAM1 1.000 APOA1 CD14 PFN1 TLN1 1.000 CPN2 IGFBP6 MST1 TLN1 1.000 CD14 CPN2 IGFBP6 S100A9 1.000 CPN2 IGFBP6 PFN1 S100A9 1.000 CD14 CPN2 PFN1 S100A8 1.000 APOA4 CD163 PFN1 S100A8 1.000 APOA4 CD14 CPN2 PFN1 1.000 CD163 S100A8 TAGLN2 VASN 1.000 CD14 CLU CPN2 PFN1 1.000 CD14 CPN2 PFN1 TAGLN2 1.000 CD163 PFN1 TLN1 VASN 1.000 CD14 CPN2 MST1 VCAM1 1.000 CD14 CPN2 PGLYRP2 TAGLN2 1.000 APOA1 CD14 CPN2 PFN1 1.000 CD14 CPN2 PFN1 SEPP1 1.000 CD163 PFN1 SEPP1 VASN 1.000 CPN2 MST1 S100A8 S100A9 1.000 CPN2 S100A8 TAGLN2 VCAM1 1.000 CD14 CPN2 PFN1 VASN 1.000 CD14 CLU PFN1 S100A8 1.000 CD14 CLU PFN1 TAGLN2 1.000 CD163 CPN2 MST1 PFN1 1.000 PFN1 S100A8 S100A9 SEPP1 1.000 CD163 CPN2 S100A8 S100A9 1.000 APOA1 CD14 PFN1 S100A8 1.000 CD14 CLU PGLYRP2 TAGLN2 1.000 CD14 CLU PFN1 S100A9 1.000 CD163 CLU PFN1 VASN 1.000 CD163 CPN2 PFN1 VASN 1.000 APOA1 CD14 CLU TAGLN2 1.000 CPN2 MST1 PFN1 VCAM1 1.000 CD163 PFN1 S100A8 TAGLN2 1.000 CD14 CPN2 PFN1 S100A9 1.000 CPN2 PFN1 S100A9 VCAM1 1.000 APOA1 CD163 S100A8 TAGLN2 1.000 CPN2 MST1 SEPP1 TLN1 1.000 CLU PFN1 S100A9 VCAM1 1.000 CPN2 IGFBP6 MST1 SEPP1 1.000 CD14 CPN2 MST1 SEPP1 1.000 CD14 CPN2 MST1 TAGLN2 1.000 CPN2 MST1 S100A8 SEPP1 1.000 APOA4 CD163 CPN2 MST1 1.000 CPN2 IGFBP6 S100A8 S100A9 1.000 CD14 CLU IGFBP6 TAGLN2 1.000 CD14 CLU PFN1 VASN 1.000 APOA4 PFN1 S100A9 SEPP1 1.000 CPN2 IGFBP6 S100A8 TAGLN2 1.000 S100A9 SEPP1 TAGLN2 VCAM1 1.000 CD14 CPN2 IGFBP6 TLN1 1.000 IGFBP6 PFN1 S100A9 VASN 1.000 PFN1 PGLYRP2 S100A8 TAGLN2 1.000 CPN2 IGFBP6 S100A9 TAGLN2 1.000 IGFBP6 PFN1 S100A8 TAGLN2 1.000 CLU PFN1 S100A8 SEPP1 1.000 MST1 PFN1 S100A8 S100A9 1.000 CD163 PFN1 VASN VCAM1 1.000 APOA1 CD163 S100A9 TAGLN2 1.000 PFN1 S100A8 SEPP1 VASN 1.000 APOA4 CD14 CLU PFN1 1.000 IGFBP6 PFN1 S100A8 VASN 1.000 PGLYRP2 SEPP1 TAGLN2 VCAM1 1.000 CD14 IGFBP6 TAGLN2 VASN 1.000 IGFBP6 PFN1 S100A9 TAGLN2 1.000 APOA4 CD163 PFN1 VASN 1.000 CD14 CLU MST1 TAGLN2 1.000 PFN1 PGLYRP2 S100A9 VASN 1.000 CD163 MST1 S100A8 S100A9 1.000 CPN2 MST1 PFN1 TAGLN2 1.000 CD14 IGFBP6 PFN1 S100A9 1.000 PFN1 PGLYRP2 S100A8 VASN 1.000 APOA4 TAGLN2 VASN VCAM1 0.999 APOA1 PFN1 S100A8 SEPP1 0.999 CPN2 MST1 PGLYRP2 TLN1 0.999 CD14 PFN1 S100A8 SEPP1 0.999 PFN1 PGLYRP2 S100A8 VCAM1 0.999 IGFBP6 PFN1 S100A8 SEPP1 0.999 MST1 PFN1 S100A8 VASN 0.999 MST1 S100A8 TAGLN2 VASN 0.999 APOA1 CD14 CD163 TAGLN2 0.999 PFN1 PGLYRP2 S100A9 SEPP1 0.999 PFN1 S100A9 SEPP1 TAGLN2 0.999 MST1 S100A9 TAGLN2 VASN 0.999 PFN1 PGLYRP2 S100A8 SEPP1 0.999 CPN2 MST1 PGLYRP2 S100A9 0.999 CLU CPN2 MST1 PFN1 0.999 CD14 PFN1 S100A8 VASN 0.999 APOA4 CD14 CPN2 MST1 0.999 CD163 CPN2 MST1 S100A8 0.999 APOA4 CD163 PFN1 S100A9 0.999 CD14 CLU CPN2 IGFBP6 0.999 APOA4 CD14 CPN2 IGFBP6 0.999 APOA1 S100A8 TAGLN2 VCAM1 0.999 CPN2 MST1 S100A8 TLN1 0.999 MST1 PFN1 S100A9 SEPP1 0.999 APOA4 CD14 CLU TAGLN2 0.999 IGFBP6 PFN1 VASN VCAM1 0.999 MST1 PFN1 S100A8 SEPP1 0.999 APOA1 CD163 PGLYRP2 TAGLN2 0.999 CD14 CPN2 SEPP1 TAGLN2 0.999 CD14 CPN2 MST1 S100A8 0.999 CLU PFN1 S100A9 SEPP1 0.999 PFN1 PGLYRP2 S100A9 VCAM1 0.999 CD14 CPN2 TAGLN2 VASN 0.999 CD14 CPN2 S100A8 TAGLN2 0.999 CD14 CLU CPN2 TAGLN2 0.999 MST1 PFN1 S100A9 VASN 0.999 CD163 S100A9 SEPP1 TAGLN2 0.999 APOA1 MST1 PFN1 S100A8 0.999 APOA1 CD14 CPN2 TAGLN2 0.999 CLU S100A8 TAGLN2 VCAM1 0.999 IGFBP6 PFN1 S100A9 VCAM1 0.999 CPN2 PGLYRP2 TAGLN2 VCAM1 0.999 IGFBP6 PFN1 S100A9 SEPP1 0.999 APOA4 CPN2 MST1 PFN1 0.999 APOA1 PFN1 S100A9 VCAM1 0.999 CPN2 MST1 S100A8 TAGLN2 0.999 CD14 PFN1 S100A9 SEPP1 0.999 CPN2 MST1 PGLYRP2 S100A8 0.999 CPN2 IGFBP6 MST1 VASN 0.999 APOA1 CD163 MST1 PFN1 0.999 CD14 CLU SEPP1 TAGLN2 0.999 CD14 CLU TAGLN2 VASN 0.999 CD14 CPN2 S100A9 TAGLN2 0.999 APOA4 CPN2 MST1 TAGLN2 0.999 CPN2 PFN1 S100A9 SEPP1 0.999 CD14 CLU S100A8 TAGLN2 0.999 APOA4 CPN2 MST1 PGLYRP2 0.999 CPN2 IGFBP6 TLN1 VCAM1 0.998 CD14 CD163 PFN1 PGLYRP2 0.998 CPN2 MST1 PGLYRP2 TAGLN2 0.998 IGFBP6 PFN1 PGLYRP2 S100A8 0.998 CD14 CPN2 MST1 S100A9 0.998 CD14 CLU S100A9 TAGLN2 0.998 CD14 CD163 CPN2 TLN1 0.998 IGFBP6 PFN1 S100A8 S100A9 0.998 CD163 CPN2 MST1 TAGLN2 0.998 CD163 CPN2 PFN1 TLN1 0.998 CD14 CPN2 PFN1 TLN1 0.998 APOA1 PFN1 PGLYRP2 VASN 0.998 APOA4 CPN2 IGFBP6 MST1 0.998 SEPP1 TAGLN2 VASN VCAM1 0.998 APOA1 PFN1 S100A9 SEPP1 0.998 CLU TAGLN2 VASN VCAM1 0.998 APOA4 CD14 CPN2 TAGLN2 0.998 CD14 CPN2 TAGLN2 TLN1 0.998 PFN1 S100A8 SEPP1 TAGLN2 0.998 PFN1 TAGLN2 VASN VCAM1 0.998 APOA4 CD163 S100A8 TAGLN2 0.998 CPN2 MST1 S100A9 TLN1 0.998 CPN2 MST1 PFN1 PGLYRP2 0.998 CPN2 MST1 S100A9 TAGLN2 0.998 CPN2 MST1 PFN1 VASN 0.998 CD14 PFN1 PGLYRP2 TLN1 0.998 APOA4 CD14 PFN1 S100A8 0.998 PFN1 S100A9 SEPP1 VASN 0.998 CD163 CLU MST1 PFN1 0.998 APOA1 CD163 MST1 TAGLN2 0.998 CPN2 MST1 PFN1 TLN1 0.998 CD14 S100A8 S100A9 TAGLN2 0.998 CLU MST1 VASN VCAM1 0.997 CPN2 MST1 PFN1 S100A9 0.997 CD14 PFN1 S100A8 TLN1 0.997 CD14 CPN2 PGLYRP2 S100A9 0.997 CD14 CLU TAGLN2 TLN1 0.997 CPN2 MST1 PFN1 S100A8 0.997 CD14 PFN1 S100A8 VCAM1 0.997 CD14 CD163 S100A9 VASN 0.997 CD163 CPN2 TLN1 VCAM1 0.997 CD14 TAGLN2 TLN1 VASN 0.997 APOA4 CPN2 MST1 TLN1 0.997 CD14 MST1 PFN1 S100A8 0.997 APOA1 CD14 CD163 PFN1 0.997 CPN2 PGLYRP2 S100A8 S100A9 0.997 APOA1 CD14 TAGLN2 TLN1 0.997 CLU IGFBP6 PFN1 S100A8 0.997 CPN2 MST1 TLN1 VASN 0.997 CLU MST1 PFN1 S100A8 0.996 PFN1 S100A8 SEPP1 TLN1 0.996 CD163 PGLYRP2 SEPP1 VASN 0.996 CD163 CPN2 PFN1 S100A8 0.996 PFN1 S100A9 SEPP1 TLN1 0.996 CD163 PFN1 PGLYRP2 VCAM1 0.996 PFN1 PGLYRP2 S100A9 TAGLN2 0.996 CD14 PFN1 S100A9 VASN 0.996 CD14 CLU PFN1 TLN1 0.995 PGLYRP2 S100A8 S100A9 TAGLN2 0.995 IGFBP6 MST1 PFN1 S100A8 0.995 CLU PFN1 S100A8 TAGLN2 0.994 CD163 CLU PFN1 S100A8 0.994 CPN2 PGLYRP2 TAGLN2 VASN 0.994 APOA4 PFN1 PGLYRP2 VCAM1 0.994 CD14 CD163 S100A8 VASN 0.993 APOA1 CPN2 IGFBP6 TLN1 0.993 CLU CPN2 MST1 TLN1 0.991 CD14 CD163 PFN1 S100A8 0.991 CD14 CPN2 S100A8 S100A9 0.989 CD14 CD163 CPN2 IGFBP6 0.986 CLU CPN2 IGFBP6 MST1 0.982 CLU CPN2 MST1 VCAM1 0.972 CPN2 MST1 TAGLN2 TLN1 0.969 CLU IGFBP6 PFN1 S100A9 0.969 APOA1 IGFBP6 PFN1 S100A9 0.967 CD163 CPN2 PGLYRP2 TLN1 0.967 APOA4 IGFBP6 PFN1 S100A8 0.967 MST1 PFN1 S100A8 TAGLN2 0.967 APOA4 CPN2 IGFBP6 TLN1 0.966 CD163 PFN1 PGLYRP2 TLN1 0.966 CD14 CD163 CLU TLN1 0.966 APOA1 IGFBP6 PFN1 S100A8 0.965 CLU PGLYRP2 TAGLN2 VCAM1 0.964 CD14 IGFBP6 PFN1 VASN 0.959 CD163 IGFBP6 PFN1 S100A9 0.959 CD163 CLU CPN2 MST1 0.958 CPN2 IGFBP6 SEPP1 TLN1 0.957 APOA4 CD163 PGLYRP2 TAGLN2 0.956 APOA1 CD163 PFN1 TAGLN2 0.956 IGFBP6 PFN1 S100A8 TLN1 0.955 CD163 CLU PGLYRP2 TLN1 0.955 CLU S100A9 TAGLN2 VCAM1 0.955 CD163 PGLYRP2 SEPP1 TAGLN2 0.952 PFN1 PGLYRP2 TLN1 VCAM1 0.951 CPN2 IGFBP6 S100A8 TLN1 0.951 CD163 MST1 PFN1 PGLYRP2 0.950 APOA4 PFN1 VASN VCAM1 0.947 IGFBP6 PFN1 PGLYRP2 VCAM1 0.946 CLU PFN1 PGLYRP2 VCAM1 0.945 CD14 PFN1 PGLYRP2 S100A8 0.942 CD163 IGFBP6 PGLYRP2 TAGLN2 0.939 CD14 CPN2 IGFBP6 PGLYRP2 0.937 CD14 TAGLN2 VASN VCAM1 0.934 CD14 IGFBP6 PFN1 PGLYRP2 0.934 APOA1 PFN1 PGLYRP2 VCAM1 0.934 IGFBP6 PGLYRP2 TAGLN2 VCAM1 0.933 CD14 CPN2 PGLYRP2 S100A8 0.933 CD14 CPN2 IGFBP6 VCAM1 0.932 MST1 PFN1 S100A8 VCAM1 0.932 CD163 CPN2 MST1 S100A9 0.931 CD163 PFN1 S100A8 VCAM1 0.931 CD163 MST1 PFN1 S100A8 0.930 CD163 CPN2 S100A8 TLN1 0.929 IGFBP6 MST1 PFN1 S100A9 0.928 CLU MST1 PFN1 S100A9 0.928 CD14 PFN1 PGLYRP2 VASN 0.928 CD163 CLU MST1 TLN1 0.927 CLU PFN1 S100A9 TAGLN2 0.927 CD14 PFN1 VASN VCAM1 0.927 CD163 PFN1 PGLYRP2 S100A9 0.927 CLU CPN2 MST1 S100A8 0.925 CD163 PFN1 S100A9 TAGLN2 0.925 CD163 CLU MST1 TAGLN2 0.925 CD14 IGFBP6 PGLYRP2 TAGLN2 0.924 APOA4 CPN2 MST1 S100A9 0.924 CPN2 PFN1 PGLYRP2 VCAM1 0.924 APOA4 IGFBP6 PFN1 S100A9 0.924 CPN2 IGFBP6 TAGLN2 TLN1 0.923 IGFBP6 PFN1 PGLYRP2 S100A9 0.923 APOA1 CD14 IGFBP6 PFN1 0.923 CD14 CPN2 IGFBP6 SEPP1 0.923 CPN2 MST1 S100A8 VASN 0.922 APOA4 CPN2 MST1 S100A8 0.922 APOA4 CLU CPN2 MST1 0.922 APOA1 CD163 IGFBP6 TAGLN2 0.922 CPN2 PFN1 VASN VCAM1 0.922 PFN1 PGLYRP2 TAGLN2 VCAM1 0.922 MST1 S100A8 SEPP1 TAGLN2 0.921 CD163 IGFBP6 PFN1 PGLYRP2 0.920 APOA4 CD14 IGFBP6 PFN1 0.920 PFN1 S100A9 TAGLN2 VCAM1 0.920 CPN2 MST1 TAGLN2 VASN 0.920 APOA1 CD163 PFN1 PGLYRP2 0.920 CPN2 MST1 S100A9 VASN 0.919 IGFBP6 S100A8 S100A9 TAGLN2 0.919 CPN2 IGFBP6 PGLYRP2 TLN1 0.919 CD163 MST1 VASN VCAM1 0.918 CLU MST1 TLN1 VCAM1 0.918 APOA1 CD14 CPN2 IGFBP6 0.917 IGFBP6 PFN1 S100A9 TLN1 0.917 APOA4 CPN2 IGFBP6 PGLYRP2 0.917 CD14 PFN1 PGLYRP2 SEPP1 0.917 CLU CPN2 MST1 S100A9 0.916 PFN1 S100A8 TLN1 VCAM1 0.916 CPN2 PFN1 S100A9 TAGLN2 0.916 CD14 PFN1 PGLYRP2 VCAM1 0.915 CD163 CPN2 PFN1 PGLYRP2 0.915 CPN2 PFN1 PGLYRP2 S100A8 0.914 MST1 PFN1 PGLYRP2 VCAM1 0.913 APOA4 MST1 PFN1 S100A8 0.913 APOA1 CD14 IGFBP6 TAGLN2 0.913 PFN1 PGLYRP2 SEPP1 VCAM1 0.913 CD163 CLU PFN1 PGLYRP2 0.912 CD163 CPN2 SEPP1 TLN1 0.912 CPN2 IGFBP6 S100A9 TLN1 0.912 IGFBP6 S100A8 TAGLN2 VCAM1 0.911 CD163 CLU S100A8 TLN1 0.911 CD163 MST1 S100A9 VASN 0.910 APOA4 CD163 CPN2 TLN1 0.909 CD163 IGFBP6 S100A8 TAGLN2 0.909 PFN1 PGLYRP2 TLN1 VASN 0.909 CPN2 PFN1 PGLYRP2 S100A9 0.909 APOA1 CD14 CPN2 PGLYRP2 0.908 APOA4 CD14 PFN1 VASN 0.907 S100A8 S100A9 SEPP1 TAGLN2 0.906 CD14 CPN2 IGFBP6 VASN 0.906 CD163 CPN2 PGLYRP2 TAGLN2 0.906 CD163 CLU CPN2 TLN1 0.905 CD14 PGLYRP2 TAGLN2 VASN 0.904 APOA1 CD163 CLU PFN1 0.903 APOA1 CD14 PFN1 PGLYRP2 0.903 APOA4 CPN2 PGLYRP2 TLN1 0.903 CLU CPN2 MST1 TAGLN2 0.902 APOA1 CD163 MST1 VASN 0.902 APOA4 CD14 PFN1 PGLYRP2 0.901 APOA4 PGLYRP2 TAGLN2 VCAM1 0.900 CD14 CLU MST1 TLN1 0.900 APOA4 PFN1 S100A8 S100A9 0.899 CD163 PGLYRP2 TAGLN2 VCAM1 0.898 APOA4 CD163 CLU TLN1 0.898 CD14 CD163 CPN2 VASN 0.898 CD14 CD163 SEPP1 TAGLN2 0.897 CD14 IGFBP6 S100A8 TAGLN2 0.897 APOA1 APOA4 CD163 TAGLN2 0.896 APOA4 CD14 IGFBP6 TAGLN2 0.896 CD163 IGFBP6 S100A9 TAGLN2 0.896 CD14 PFN1 PGLYRP2 TAGLN2 0.896 PFN1 S100A8 S100A9 TLN1 0.895 PFN1 S100A8 S100A9 TAGLN2 0.895 PGLYRP2 S100A8 TAGLN2 VCAM1 0.894 CPN2 IGFBP6 PFN1 TLN1 0.894 CD14 S100A8 TAGLN2 VASN 0.894 CD163 CLU IGFBP6 TLN1 0.892 APOA1 CD163 PFN1 TLN1 0.892 APOA4 PFN1 S100A8 TAGLN2 0.892 CD14 S100A9 TAGLN2 VASN 0.892 APOA4 CD14 CPN2 TLN1 0.891 CPN2 S100A8 S100A9 SEPP1 0.891 CD14 IGFBP6 PFN1 SEPP1 0.891 CLU MST1 TAGLN2 VCAM1 0.891 CPN2 PFN1 PGLYRP2 TLN1 0.890 CD14 CD163 PGLYRP2 TAGLN2 0.890 APOA1 PGLYRP2 TAGLN2 VCAM1 0.890 APOA4 CD163 PFN1 PGLYRP2 0.890 CD163 CLU S100A9 TLN1 0.890 CD14 PFN1 PGLYRP2 S100A9 0.890 APOA4 S100A8 TAGLN2 VCAM1 0.889 CD14 PGLYRP2 TAGLN2 VCAM1 0.889 CD163 MST1 PGLYRP2 VASN 0.889 CD163 MST1 PGLYRP2 TAGLN2 0.888 CLU MST1 S100A8 TAGLN2 0.888 CPN2 S100A9 TAGLN2 VCAM1 0.888 CD14 IGFBP6 S100A9 TAGLN2 0.887 APOA1 CD14 PGLYRP2 TAGLN2 0.887 CPN2 PFN1 S100A8 TAGLN2 0.887 APOA1 PFN1 S100A8 TAGLN2 0.887 CD14 PFN1 S100A9 TAGLN2 0.887 CD14 PFN1 TAGLN2 VASN 0.887 CPN2 IGFBP6 TAGLN2 VCAM1 0.887 CD14 PFN1 SEPP1 TLN1 0.886 CD14 PGLYRP2 TAGLN2 TLN1 0.886 CD163 CPN2 MST1 VCAM1 0.886 CD14 IGFBP6 SEPP1 TAGLN2 0.886 CPN2 IGFBP6 TLN1 VASN 0.886 CD163 IGFBP6 MST1 VASN 0.884 CD163 PFN1 PGLYRP2 S100A8 0.884 CD14 MST1 PFN1 PGLYRP2 0.884 MST1 PFN1 S100A9 TAGLN2 0.884 APOA4 CD14 PGLYRP2 TAGLN2 0.883 CD163 MST1 S100A8 VASN 0.883 CPN2 PGLYRP2 S100A8 TAGLN2 0.883 CLU PFN1 VASN VCAM1 0.882 MST1 PFN1 PGLYRP2 S100A9 0.882 CD163 MST1 SEPP1 VASN 0.882 CLU PFN1 S100A8 S100A9 0.882 CD163 PFN1 PGLYRP2 SEPP1 0.882 PGLYRP2 S100A9 TAGLN2 VCAM1 0.881 CD14 CPN2 S100A8 TLN1 0.881 MST1 PFN1 PGLYRP2 S100A8 0.880 CPN2 IGFBP6 PFN1 VCAM1 0.880 CD14 MST1 TAGLN2 VASN 0.879 APOA1 PFN1 S100A9 TAGLN2 0.879 APOA1 CD14 PFN1 VASN 0.879 APOA1 PFN1 S100A8 S100A9 0.878 PFN1 S100A8 TAGLN2 VASN 0.878 CD14 SEPP1 TAGLN2 TLN1 0.878 MST1 PFN1 PGLYRP2 TAGLN2 0.878 APOA1 CD163 IGFBP6 PFN1 0.878 CD14 CPN2 TLN1 VASN 0.877 CPN2 S100A8 S100A9 TAGLN2 0.877 APOA1 TAGLN2 VASN VCAM1 0.877 MST1 S100A9 SEPP1 TAGLN2 0.877 CLU MST1 S100A9 TAGLN2 0.877 CPN2 IGFBP6 SEPP1 VCAM1 0.876 CLU MST1 PFN1 PGLYRP2 0.876 APOA4 S100A8 SEPP1 TAGLN2 0.876 CLU MST1 PFN1 VCAM1 0.876 MST1 PGLYRP2 TAGLN2 VASN 0.876 CLU MST1 PGLYRP2 TAGLN2 0.876 MST1 TAGLN2 VASN VCAM1 0.875 CLU CPN2 IGFBP6 TLN1 0.875 MST1 PFN1 S100A8 TLN1 0.875 MST1 S100A9 VASN VCAM1 0.875 APOA1 CD14 TAGLN2 VASN 0.875 MST1 PFN1 VASN VCAM1 0.874 IGFBP6 PFN1 PGLYRP2 VASN 0.874 CPN2 PFN1 PGLYRP2 VASN 0.874 MST1 PFN1 PGLYRP2 TLN1 0.874 CLU CPN2 IGFBP6 VCAM1 0.874 APOA1 CD14 CPN2 TLN1 0.874 MST1 PFN1 PGLYRP2 VASN 0.874 CD14 CLU S100A8 TLN1 0.874 PGLYRP2 TAGLN2 TLN1 VCAM1 0.874 CD163 CPN2 IGFBP6 PGLYRP2 0.873 APOA1 CD14 CLU TLN1 0.873 CPN2 IGFBP6 VASN VCAM1 0.873 APOA4 CD14 PFN1 SEPP1 0.873 CD14 CLU SEPP1 TLN1 0.872 CPN2 PFN1 S100A8 S100A9 0.872 MST1 PGLYRP2 TAGLN2 VCAM1 0.872 CD14 PGLYRP2 SEPP1 TAGLN2 0.872 CD14 CD163 CLU VASN 0.872 PGLYRP2 S100A8 S100A9 TLN1 0.872 CD14 CPN2 SEPP1 TLN1 0.872 IGFBP6 MST1 PGLYRP2 TAGLN2 0.872 CD163 CLU PFN1 TLN1 0.871 PFN1 S100A8 TAGLN2 TLN1 0.871 CD163 CPN2 S100A9 TLN1 0.871 CPN2 IGFBP6 PFN1 PGLYRP2 0.871 CD163 CPN2 TAGLN2 TLN1 0.871 APOA4 CD14 TAGLN2 VASN 0.871 CD14 IGFBP6 PFN1 TAGLN2 0.871 CD14 MST1 PGLYRP2 TAGLN2 0.871 CD14 CPN2 S100A9 TLN1 0.870 APOA4 CLU MST1 TAGLN2 0.870 CD14 PGLYRP2 S100A9 TAGLN2 0.870 APOA1 MST1 PFN1 S100A9 0.869 CD14 PGLYRP2 S100A8 TAGLN2 0.869 APOA1 CD163 CLU TAGLN2 0.869 APOA4 PFN1 S100A9 TAGLN2 0.869 APOA4 CD14 PFN1 S100A9 0.869 APOA1 MST1 PFN1 PGLYRP2 0.869 APOA1 S100A8 S100A9 TAGLN2 0.869 PFN1 SEPP1 VASN VCAM1 0.868 IGFBP6 MST1 S100A8 TAGLN2 0.868 CPN2 PFN1 PGLYRP2 TAGLN2 0.868 CLU PFN1 PGLYRP2 S100A8 0.868 APOA4 PFN1 PGLYRP2 VASN 0.868 IGFBP6 MST1 PFN1 PGLYRP2 0.868 MST1 PGLYRP2 SEPP1 TAGLN2 0.868 APOA4 CD14 CLU TLN1 0.867 CLU PFN1 PGLYRP2 VASN 0.867 CD14 CPN2 TLN1 VCAM1 0.867 CD14 PFN1 SEPP1 VASN 0.867 APOA1 MST1 S100A8 TAGLN2 0.867 APOA4 CD14 CPN2 S100A9 0.867 APOA1 IGFBP6 S100A8 S100A9 0.867 APOA4 CD163 MST1 VASN 0.867 CD14 CLU TLN1 VCAM1 0.867 APOA1 PFN1 PGLYRP2 S100A8 0.866 CD14 IGFBP6 MST1 PFN1 0.866 APOA1 CD14 PFN1 S100A9 0.866 APOA4 CLU MST1 PFN1 0.866 APOA1 MST1 S100A8 S100A9 0.866 APOA4 PFN1 PGLYRP2 S100A8 0.866 CD14 SEPP1 TAGLN2 VASN 0.866 CPN2 PGLYRP2 S100A9 TAGLN2 0.866 CD14 CD163 MST1 VASN 0.865 CD14 S100A8 SEPP1 TAGLN2 0.865 IGFBP6 S100A9 TAGLN2 VCAM1 0.865 CPN2 IGFBP6 PGLYRP2 TAGLN2 0.865 APOA4 CPN2 MST1 VASN 0.865 APOA4 CD163 S100A9 TAGLN2 0.864 APOA4 CLU PFN1 S100A8 0.864 CD14 CLU IGFBP6 TLN1 0.864 CD14 CLU S100A9 TLN1 0.864 APOA1 CPN2 PGLYRP2 TLN1 0.863 APOA1 CD163 TAGLN2 TLN1 0.863 PFN1 PGLYRP2 TAGLN2 VASN 0.863 CD14 CLU TLN1 VASN 0.862 CD14 CPN2 PGLYRP2 TLN1 0.862 CLU IGFBP6 MST1 PFN1 0.862 IGFBP6 S100A8 TAGLN2 VASN 0.862 CD163 IGFBP6 S100A8 VASN 0.862 MST1 PGLYRP2 TAGLN2 TLN1 0.862 MST1 PFN1 PGLYRP2 SEPP1 0.862 CD163 PFN1 PGLYRP2 TAGLN2 0.862 PFN1 PGLYRP2 S100A8 TLN1 0.861 APOA1 S100A9 TAGLN2 VCAM1 0.861 CD163 CPN2 IGFBP6 VASN 0.861 APOA4 CD14 SEPP1 TAGLN2 0.861 PGLYRP2 S100A8 S100A9 VASN 0.861 APOA1 PFN1 VASN VCAM1 0.860 MST1 PGLYRP2 S100A9 TAGLN2 0.859 PFN1 PGLYRP2 S100A9 TLN1 0.859 CD14 CD163 CPN2 S100A9 0.859 CLU CPN2 IGFBP6 PGLYRP2 0.859 APOA4 MST1 PFN1 S100A9 0.859 CD163 IGFBP6 S100A9 VASN 0.859 CD14 CLU CPN2 TLN1 0.858 APOA1 CPN2 PFN1 S100A8 0.858 APOA4 CD14 CPN2 S100A8 0.858 APOA1 APOA4 CD163 PFN1 0.857 IGFBP6 S100A8 S100A9 TLN1 0.857 CD163 PGLYRP2 TAGLN2 TLN1 0.857 CD14 CD163 CPN2 S100A8 0.857 IGFBP6 PGLYRP2 S100A8 TAGLN2 0.857 PFN1 PGLYRP2 SEPP1 VASN 0.857 MST1 PGLYRP2 S100A8 TAGLN2 0.856 CD14 CPN2 PGLYRP2 SEPP1 0.856 APOA1 CD163 CPN2 PFN1 0.856 APOA1 PGLYRP2 S100A8 S100A9 0.856 CD14 CLU PGLYRP2 TLN1 0.856 CLU S100A8 SEPP1 TAGLN2 0.856 PGLYRP2 TAGLN2 TLN1 VASN 0.855 APOA1 PFN1 S100A8 TLN1 0.855 CPN2 IGFBP6 PGLYRP2 VCAM1 0.855 PGLYRP2 TLN1 VASN VCAM1 0.854 MST1 TLN1 VASN VCAM1 0.854 APOA1 CD163 PFN1 VCAM1 0.853 APOA1 CD163 PFN1 SEPP1 0.853 CD163 CLU IGFBP6 TAGLN2 0.853 APOA4 MST1 S100A8 TAGLN2 0.853 CD14 CLU MST1 VCAM1 0.853 CD14 PFN1 TLN1 VASN 0.853 CD14 CPN2 S100A9 VCAM1 0.852 CD14 CPN2 S100A9 VASN 0.852 APOA1 PFN1 S100A9 TLN1 0.852 CPN2 S100A8 SEPP1 TAGLN2 0.852 APOA4 PFN1 PGLYRP2 S100A9 0.852 CD163 CLU TAGLN2 TLN1 0.851 APOA4 CD163 IGFBP6 VASN 0.851 CD14 CPN2 S100A9 SEPP1 0.851 CD14 CPN2 S100A8 VASN 0.851 APOA4 CPN2 S100A8 S100A9 0.851 CD163 IGFBP6 SEPP1 VASN 0.851 CD163 CLU SEPP1 TLN1 0.851 CLU S100A9 SEPP1 TAGLN2 0.850 APOA4 PFN1 S100A9 VCAM1 0.850 IGFBP6 S100A8 SEPP1 TAGLN2 0.850 APOA1 CD14 S100A8 S100A9 0.850 CD14 CD163 CLU MST1 0.850 APOA1 MST1 S100A9 TAGLN2 0.850 APOA1 PFN1 S100A8 VASN 0.850 CPN2 IGFBP6 S100A9 VCAM1 0.849 APOA4 CD14 CPN2 PGLYRP2 0.849 APOA4 S100A8 S100A9 TAGLN2 0.849 APOA1 PFN1 PGLYRP2 S100A9 0.849 CLU IGFBP6 MST1 VCAM1 0.849 CD14 PFN1 S100A9 VCAM1 0.849 APOA4 CPN2 IGFBP6 VCAM1 0.849 IGFBP6 MST1 S100A9 TAGLN2 0.849 CD14 CD163 PFN1 SEPP1 0.848 CPN2 PGLYRP2 TAGLN2 TLN1 0.848 APOA4 PGLYRP2 S100A8 S100A9 0.848 APOA4 CD163 PFN1 SEPP1 0.848 APOA1 CLU PFN1 S100A8 0.848 CD163 CPN2 IGFBP6 S100A9 0.848 APOA1 CD163 CPN2 TLN1 0.847 CLU IGFBP6 S100A8 TAGLN2 0.847 IGFBP6 MST1 TAGLN2 VASN 0.847 CLU IGFBP6 S100A9 TAGLN2 0.846 APOA4 CD163 PGLYRP2 VASN 0.846 CD163 CLU TLN1 VCAM1 0.846 CD14 CPN2 PGLYRP2 VASN 0.846 CD14 S100A9 SEPP1 TAGLN2 0.846 CLU MST1 PGLYRP2 VCAM1 0.846 MST1 PGLYRP2 VASN VCAM1 0.846 CD163 IGFBP6 PGLYRP2 VASN 0.845 APOA4 CD163 IGFBP6 TAGLN2 0.845 CPN2 IGFBP6 S100A8 VCAM1 0.845 CD14 CLU CPN2 S100A9 0.845 CPN2 PGLYRP2 TLN1 VCAM1 0.845 CLU MST1 SEPP1 TAGLN2 0.845 CLU PGLYRP2 S100A8 S100A9 0.844 CD14 CPN2 S100A8 VCAM1 0.844 APOA1 CLU PFN1 S100A9 0.844 CD14 CD163 IGFBP6 VASN 0.844 CD163 CLU PGLYRP2 TAGLN2 0.844 CD14 CD163 CPN2 PGLYRP2 0.843 CD14 CPN2 PGLYRP2 VCAM1 0.843 APOA4 CD14 PFN1 TLN1 0.843 MST1 PFN1 SEPP1 VASN 0.843 CLU IGFBP6 MST1 TAGLN2 0.843 PFN1 S100A9 TAGLN2 VASN 0.842 APOA1 CD14 S100A9 TAGLN2 0.842 CLU MST1 S100A8 TLN1 0.842 CLU MST1 S100A9 TLN1 0.842 APOA4 PFN1 S100A8 VASN 0.842 IGFBP6 PGLYRP2 S100A8 S100A9 0.842 CPN2 PGLYRP2 SEPP1 TLN1 0.841 APOA1 CD14 S100A8 TAGLN2 0.840 APOA1 PGLYRP2 TAGLN2 VASN 0.840 CLU MST1 S100A8 S100A9 0.840 APOA1 CD14 CPN2 S100A9 0.840 MST1 S100A8 VASN VCAM1 0.839 CD163 CLU IGFBP6 MST1 0.839 CD163 CPN2 IGFBP6 S100A8 0.839 APOA1 CD163 IGFBP6 VASN 0.839 APOA4 CLU PFN1 S100A9 0.839 APOA4 CD163 CLU MST1 0.839 CPN2 S100A9 SEPP1 TAGLN2 0.839 CD14 CD163 VASN VCAM1 0.838 PFN1 S100A8 S100A9 VASN 0.838 CD163 CLU MST1 PGLYRP2 0.838 CD163 CLU IGFBP6 PFN1 0.838 S100A8 S100A9 SEPP1 TLN1 0.838 CD14 CPN2 VASN VCAM1 0.838 S100A8 SEPP1 TAGLN2 TLN1 0.837 CD14 CD163 IGFBP6 PFN1 0.837 APOA1 CD163 PGLYRP2 VASN 0.836 APOA4 CPN2 IGFBP6 S100A8 0.836 APOA4 CD14 S100A8 TAGLN2 0.836 CD163 IGFBP6 VASN VCAM1 0.836 IGFBP6 MST1 VASN VCAM1 0.835 CLU CPN2 PFN1 PGLYRP2 0.835 APOA4 CD14 CD163 TAGLN2 0.835 CLU IGFBP6 PFN1 VCAM1 0.835 APOA4 MST1 VASN VCAM1 0.835 APOA4 CD14 CD163 PFN1 0.835 APOA4 CPN2 TAGLN2 VCAM1 0.834 APOA4 CD163 PGLYRP2 TLN1 0.833 CD14 S100A8 TAGLN2 VCAM1 0.833 CD14 MST1 PFN1 SEPP1 0.832 CD163 CPN2 PFN1 SEPP1 0.832 IGFBP6 PFN1 PGLYRP2 SEPP1 0.831 APOA1 MST1 PGLYRP2 TAGLN2 0.831 PGLYRP2 SEPP1 TAGLN2 VASN 0.830 CPN2 PGLYRP2 SEPP1 TAGLN2 0.830 CD163 MST1 SEPP1 TAGLN2 0.830 IGFBP6 PGLYRP2 TAGLN2 VASN 0.830 APOA1 CD163 SEPP1 TAGLN2 0.829 CPN2 IGFBP6 PGLYRP2 SEPP1 0.829 APOA4 CD163 MST1 TAGLN2 0.829 PGLYRP2 SEPP1 VASN VCAM1 0.829 IGFBP6 S100A9 TAGLN2 VASN 0.829 APOA1 CPN2 S100A8 S100A9 0.829 CD163 CLU IGFBP6 VASN 0.829 CD163 PGLYRP2 S100A8 VASN 0.829 CD163 PGLYRP2 S100A9 TAGLN2 0.828 CLU S100A8 S100A9 TAGLN2 0.828 S100A8 S100A9 TAGLN2 TLN1 0.828 CD14 CD163 PGLYRP2 VASN 0.828 CD14 PGLYRP2 TLN1 VASN 0.828 CD163 PGLYRP2 S100A9 TLN1 0.827 PGLYRP2 S100A9 TAGLN2 VASN 0.827 CLU PGLYRP2 TAGLN2 VASN 0.827 CPN2 PFN1 PGLYRP2 SEPP1 0.827 CPN2 PGLYRP2 S100A9 TLN1 0.827 APOA4 MST1 PFN1 PGLYRP2 0.827 MST1 SEPP1 TAGLN2 VASN 0.827 APOA4 MST1 PFN1 VASN 0.827 CPN2 PGLYRP2 TLN1 VASN 0.827 APOA1 APOA4 S100A8 S100A9 0.827 CPN2 S100A8 S100A9 TLN1 0.827 APOA1 CD14 CPN2 VASN 0.827 CLU IGFBP6 TLN1 VCAM1 0.826 APOA4 CPN2 IGFBP6 S100A9 0.826 IGFBP6 MST1 PFN1 VASN 0.825 S100A9 SEPP1 TAGLN2 TLN1 0.825 CLU PFN1 S100A8 VASN 0.824 CD163 PGLYRP2 S100A9 VASN 0.824 CD163 CPN2 IGFBP6 PFN1 0.824 CD163 PFN1 SEPP1 TLN1 0.824 APOA1 MST1 VASN VCAM1 0.824 CLU MST1 PFN1 SEPP1 0.824 CD14 IGFBP6 PFN1 VCAM1 0.824 APOA4 CD163 MST1 PFN1 0.823 APOA4 CD163 SEPP1 TAGLN2 0.823 CPN2 PGLYRP2 S100A8 TLN1 0.823 MST1 S100A8 TAGLN2 VCAM1 0.823 CD163 MST1 PFN1 SEPP1 0.823 APOA4 SEPP1 TAGLN2 VCAM1 0.823 CD14 CLU CPN2 PGLYRP2 0.823 APOA1 PFN1 S100A9 VASN 0.822 CD14 CLU CPN2 VASN 0.822 APOA4 PFN1 S100A9 VASN 0.822 CD14 CD163 CPN2 SEPP1 0.822 MST1 PGLYRP2 TLN1 VASN 0.822 APOA4 CD163 IGFBP6 PFN1 0.821 CD163 CLU CPN2 PGLYRP2 0.821 CD14 CLU SEPP1 VCAM1 0.821 APOA1 CD14 CD163 CPN2 0.821 APOA1 CPN2 PFN1 PGLYRP2 0.821 APOA4 S100A9 TAGLN2 VCAM1 0.821 APOA1 S100A8 S100A9 SEPP1 0.821 CD14 CD163 IGFBP6 TAGLN2 0.821 CD14 MST1 S100A8 TAGLN2 0.820 CPN2 S100A8 S100A9 VASN 0.820 IGFBP6 PFN1 PGLYRP2 TAGLN2 0.820 CD14 CD163 PFN1 S100A9 0.820 PGLYRP2 S100A8 TAGLN2 VASN 0.820 CD14 IGFBP6 TAGLN2 TLN1 0.820 CPN2 PFN1 TAGLN2 VCAM1 0.820 IGFBP6 PGLYRP2 S100A9 TAGLN2 0.820 MST1 PFN1 TAGLN2 VASN 0.820 APOA1 IGFBP6 PFN1 PGLYRP2 0.819 CD14 TLN1 VASN VCAM1 0.819 APOA4 PFN1 S100A8 TLN1 0.819 APOA4 MST1 PGLYRP2 TAGLN2 0.819 CLU MST1 PGLYRP2 TLN1 0.819 CD163 CLU PFN1 S100A9 0.819 APOA4 CPN2 PFN1 PGLYRP2 0.819 APOA4 IGFBP6 TAGLN2 VCAM1 0.819 CD14 CD163 CPN2 VCAM1 0.819 APOA4 IGFBP6 PFN1 PGLYRP2 0.819 CD14 MST1 PFN1 S100A9 0.819 IGFBP6 TLN1 VASN VCAM1 0.818 APOA4 MST1 PFN1 SEPP1 0.818 APOA1 CPN2 IGFBP6 PGLYRP2 0.818 S100A8 S100A9 TAGLN2 VASN 0.818 CPN2 PFN1 S100A8 TLN1 0.818 APOA1 CD14 PFN1 SEPP1 0.817 APOA1 CD163 CPN2 TAGLN2 0.817 CLU CPN2 PGLYRP2 TAGLN2 0.817 APOA4 CD163 SEPP1 TLN1 0.817 APOA1 IGFBP6 PGLYRP2 TAGLN2 0.817 CD163 SEPP1 TAGLN2 TLN1 0.817 CLU IGFBP6 TAGLN2 VCAM1 0.816 APOA4 IGFBP6 PGLYRP2 TAGLN2 0.816 IGFBP6 S100A9 SEPP1 TAGLN2 0.816 CD14 MST1 VASN VCAM1 0.816 APOA1 APOA4 PFN1 S100A8 0.816 MST1 SEPP1 VASN VCAM1 0.816 CD14 IGFBP6 MST1 TAGLN2 0.816 TAGLN2 TLN1 VASN VCAM1 0.816 IGFBP6 PGLYRP2 SEPP1 TAGLN2 0.815 APOA4 CD14 TAGLN2 TLN1 0.815 APOA1 CPN2 IGFBP6 VCAM1 0.815 CD14 CD163 SEPP1 VASN 0.815 IGFBP6 SEPP1 VASN VCAM1 0.815 IGFBP6 PGLYRP2 VASN VCAM1 0.815 APOA1 CD14 PGLYRP2 TLN1 0.815 CD163 CPN2 PFN1 S100A9 0.814 CPN2 IGFBP6 PGLYRP2 VASN 0.814 APOA4 PGLYRP2 SEPP1 TAGLN2 0.814 CD14 IGFBP6 PFN1 TLN1 0.814 CLU CPN2 PGLYRP2 VCAM1 0.814 CPN2 PFN1 S100A8 VASN 0.814 APOA4 CD14 PGLYRP2 TLN1 0.814 APOA1 CD14 CD163 VASN 0.814 APOA1 CD14 CPN2 VCAM1 0.813 CD14 CLU MST1 VASN 0.813 CD14 IGFBP6 TAGLN2 VCAM1 0.813 APOA1 CD163 CPN2 IGFBP6 0.813 CD163 PFN1 S100A8 TLN1 0.813 CLU IGFBP6 S100A8 S100A9 0.812 APOA4 IGFBP6 MST1 PFN1 0.812 CD163 CLU PGLYRP2 VASN 0.812 CLU MST1 PFN1 VASN 0.812 APOA4 PFN1 PGLYRP2 SEPP1 0.812 CD163 MST1 S100A8 TAGLN2 0.812 APOA4 MST1 S100A9 TAGLN2 0.812 APOA4 S100A9 SEPP1 TAGLN2 0.812 CD163 CPN2 IGFBP6 TAGLN2 0.811 APOA4 CD14 CPN2 VASN 0.811 CPN2 IGFBP6 PGLYRP2 S100A9 0.811 CD14 CLU MST1 PGLYRP2 0.811 CD14 MST1 PFN1 VASN 0.811 APOA1 PGLYRP2 VASN VCAM1 0.811 MST1 PFN1 S100A9 VCAM1 0.811 APOA1 APOA4 CD14 CPN2 0.810 CLU CPN2 IGFBP6 PFN1 0.810 APOA1 IGFBP6 S100A8 TAGLN2 0.810 CD14 PFN1 SEPP1 VCAM1 0.810 APOA4 PFN1 PGLYRP2 TLN1 0.810 APOA4 PGLYRP2 TLN1 VCAM1 0.810 CD163 PGLYRP2 S100A8 TAGLN2 0.810 CLU IGFBP6 PGLYRP2 TAGLN2 0.810 IGFBP6 PFN1 PGLYRP2 TLN1 0.809 CLU CPN2 MST1 VASN 0.809 APOA4 IGFBP6 S100A8 S100A9 0.809 APOA4 PGLYRP2 TAGLN2 VASN 0.809 PGLYRP2 S100A8 SEPP1 TAGLN2 0.809 APOA4 CD14 CD163 VASN 0.809 PFN1 TLN1 VASN VCAM1 0.808 CLU CPN2 PGLYRP2 TLN1 0.808 APOA1 IGFBP6 VASN VCAM1 0.808 CD14 IGFBP6 VASN VCAM1 0.808 APOA4 S100A8 S100A9 SEPP1 0.808 APOA1 CLU S100A8 S100A9 0.808 CD14 MST1 SEPP1 TAGLN2 0.807 CD163 CLU CPN2 IGFBP6 0.807 CD14 CLU IGFBP6 MST1 0.807 CD14 CD163 CLU CPN2 0.806 CD14 PFN1 S100A9 TLN1 0.805 APOA1 CD14 CLU MST1 0.805 APOA4 CLU CPN2 PGLYRP2 0.805 APOA4 MST1 S100A8 S100A9 0.805 CD163 CPN2 PGLYRP2 VASN 0.805 CD163 CPN2 IGFBP6 VCAM1 0.805 CD14 CPN2 SEPP1 VASN 0.804 CD14 CLU S100A9 VCAM1 0.804 APOA4 CPN2 PFN1 S100A8 0.804 PGLYRP2 S100A8 S100A9 SEPP1 0.804 CLU PGLYRP2 TLN1 VCAM1 0.804 APOA4 PGLYRP2 SEPP1 TLN1 0.804 APOA4 IGFBP6 PGLYRP2 TLN1 0.803 CD14 CD163 PGLYRP2 S100A9 0.803 APOA1 CD163 IGFBP6 S100A9 0.803 CPN2 PFN1 SEPP1 VCAM1 0.803 CLU CPN2 PGLYRP2 S100A9 0.803 CD163 PGLYRP2 VASN VCAM1 0.803 CPN2 IGFBP6 PGLYRP2 S100A8 0.802 CLU IGFBP6 PFN1 PGLYRP2 0.802 CD14 S100A8 S100A9 TLN1 0.802 APOA4 CD163 TAGLN2 TLN1 0.802 APOA4 S100A8 S100A9 TLN1 0.802 APOA4 CD14 IGFBP6 TLN1 0.801 CLU CPN2 PFN1 S100A8 0.801 MST1 PFN1 SEPP1 TLN1 0.801 APOA4 CD14 CD163 CPN2 0.801 APOA1 CD14 SEPP1 TAGLN2 0.800 MST1 PGLYRP2 S100A8 S100A9 0.800 CD14 CLU MST1 SEPP1 0.800 CD163 IGFBP6 PFN1 TLN1 0.800 CPN2 PFN1 S100A9 VASN 0.800 APOA4 CD14 TLN1 VASN 0.799 CLU IGFBP6 MST1 TLN1 0.799 APOA1 S100A8 S100A9 TLN1 0.799 APOA1 CD14 TLN1 VASN 0.798 CD163 PFN1 S100A9 VCAM1 0.798 CD163 IGFBP6 PGLYRP2 S100A9 0.798 PFN1 S100A9 TLN1 VCAM1 0.798 APOA1 CD14 TAGLN2 VCAM1 0.798 CLU MST1 PGLYRP2 VASN 0.798 CLU CPN2 PGLYRP2 VASN 0.797 APOA1 CLU PGLYRP2 TLN1 0.797 IGFBP6 S100A9 VASN VCAM1 0.797 APOA4 CLU TAGLN2 VCAM1 0.797 APOA4 CD163 PFN1 TLN1 0.797 APOA1 CPN2 PFN1 VCAM1 0.797 APOA4 MST1 TAGLN2 TLN1 0.797 APOA1 CD14 MST1 PFN1 0.797 CD14 CLU IGFBP6 S100A9 0.797 S100A8 SEPP1 TAGLN2 VASN 0.796 APOA1 CD14 PFN1 TAGLN2 0.796 APOA1 IGFBP6 S100A9 TAGLN2 0.796 CD163 IGFBP6 PFN1 SEPP1 0.796 APOA4 CLU MST1 VCAM1 0.796 APOA1 CD14 PFN1 VCAM1 0.796 APOA1 S100A8 S100A9 VASN 0.796 CD14 CPN2 SEPP1 VCAM1 0.796 CD163 IGFBP6 PGLYRP2 S100A8 0.796 APOA4 CPN2 PFN1 VCAM1 0.796 CLU MST1 S100A8 VCAM1 0.796 APOA4 CD14 CPN2 SEPP1 0.796 APOA1 CD163 CLU TLN1 0.796 CD14 CPN2 S100A8 SEPP1 0.796 CLU CPN2 PGLYRP2 S100A8 0.796 APOA1 APOA4 CD14 PFN1 0.795 CD163 CPN2 IGFBP6 SEPP1 0.795 APOA1 CPN2 IGFBP6 TAGLN2 0.795 IGFBP6 S100A8 S100A9 SEPP1 0.795 CLU IGFBP6 VASN VCAM1 0.795 CPN2 S100A8 TAGLN2 TLN1 0.795 CLU MST1 SEPP1 VCAM1 0.795 IGFBP6 MST1 PFN1 SEPP1 0.794 CD163 IGFBP6 SEPP1 TAGLN2 0.794 CD163 MST1 PFN1 S100A9 0.794 APOA4 MST1 PFN1 TLN1 0.794 CLU CPN2 IGFBP6 TAGLN2 0.794 CD14 CLU PGLYRP2 S100A9 0.793 S100A9 SEPP1 TAGLN2 VASN 0.793 CLU PFN1 PGLYRP2 TLN1 0.793 CLU S100A8 S100A9 TLN1 0.793 APOA4 CPN2 PFN1 S100A9 0.793 S100A8 TLN1 VASN VCAM1 0.793 APOA4 CD14 MST1 PFN1 0.793 APOA4 MST1 SEPP1 TAGLN2 0.792 CPN2 PFN1 TLN1 VCAM1 0.792 CD163 PFN1 SEPP1 TAGLN2 0.792 CD14 CLU CPN2 S100A8 0.792 CLU MST1 PGLYRP2 SEPP1 0.792 APOA4 IGFBP6 VASN VCAM1 0.792 APOA4 CD14 PFN1 TAGLN2 0.792 APOA1 APOA4 PFN1 PGLYRP2 0.791 APOA4 IGFBP6 S100A8 TAGLN2 0.791 PGLYRP2 S100A9 SEPP1 TAGLN2 0.791 APOA1 APOA4 PFN1 S100A9 0.791 IGFBP6 SEPP1 TAGLN2 VCAM1 0.791 APOA4 PFN1 S100A9 TLN1 0.790 APOA4 CD14 S100A9 TAGLN2 0.790 APOA4 CD14 CLU MST1 0.790 APOA1 S100A8 SEPP1 TAGLN2 0.790 APOA4 CLU IGFBP6 TLN1 0.790 APOA4 CD14 PFN1 VCAM1 0.790 PFN1 PGLYRP2 SEPP1 TAGLN2 0.789 APOA4 IGFBP6 S100A8 TLN1 0.789 APOA1 APOA4 CD163 VASN 0.789 CD14 CLU IGFBP6 VCAM1 0.789 IGFBP6 S100A8 VASN VCAM1 0.789 S100A9 TLN1 VASN VCAM1 0.789 CPN2 PFN1 S100A9 TLN1 0.789 APOA1 CPN2 PFN1 S100A9 0.789 MST1 S100A8 S100A9 TLN1 0.789 CD163 MST1 PGLYRP2 S100A9 0.789 CD163 SEPP1 TAGLN2 VCAM1 0.788 CD163 CLU MST1 S100A9 0.788 CPN2 S100A8 TLN1 VCAM1 0.788 CD163 CLU MST1 S100A8 0.787 CD163 PGLYRP2 SEPP1 TLN1 0.787 CD163 CLU S100A8 TAGLN2 0.787 CD163 PFN1 S100A9 TLN1 0.787 CD163 CLU SEPP1 TAGLN2 0.787 APOA4 CD163 CLU PFN1 0.787 APOA4 CD14 TAGLN2 VCAM1 0.787 APOA1 CPN2 TAGLN2 VCAM1 0.787 APOA4 MST1 PGLYRP2 TLN1 0.787 IGFBP6 MST1 SEPP1 TAGLN2 0.787 CD14 PGLYRP2 VASN VCAM1 0.787 CPN2 IGFBP6 PFN1 TAGLN2 0.786 APOA4 CD163 IGFBP6 TLN1 0.786 APOA1 IGFBP6 MST1 TAGLN2 0.786 CD163 CPN2 S100A8 TAGLN2 0.786 CLU S100A8 TLN1 VCAM1 0.786 CD163 CLU PFN1 SEPP1 0.786 CPN2 PGLYRP2 VASN VCAM1 0.785 MST1 S100A8 TLN1 VASN 0.785 APOA1 CD163 TAGLN2 VCAM1 0.785 IGFBP6 S100A8 TAGLN2 TLN1 0.785 PGLYRP2 S100A9 VASN VCAM1 0.785 IGFBP6 S100A8 S100A9 VASN 0.784 CPN2 IGFBP6 PFN1 VASN 0.784 APOA4 IGFBP6 MST1 TAGLN2 0.784 IGFBP6 MST1 S100A8 S100A9 0.784 CLU PFN1 S100A8 TLN1 0.784 APOA4 IGFBP6 S100A9 TLN1 0.784 CLU CPN2 IGFBP6 S100A8 0.784 APOA4 CD14 S100A8 S100A9 0.783 APOA4 IGFBP6 MST1 TLN1 0.783 APOA1 CD163 CLU MST1 0.783 S100A8 S100A9 SEPP1 VASN 0.783 S100A8 S100A9 TLN1 VASN 0.783 APOA4 CPN2 PGLYRP2 TAGLN2 0.783 IGFBP6 PGLYRP2 TAGLN2 TLN1 0.783 APOA1 CD14 MST1 TAGLN2 0.783 APOA1 CPN2 IGFBP6 PFN1 0.783 MST1 SEPP1 TAGLN2 VCAM1 0.782 MST1 S100A8 S100A9 SEPP1 0.782 APOA1 MST1 PFN1 SEPP1 0.782 APOA1 PGLYRP2 S100A8 TAGLN2 0.781 CD14 CLU S100A8 S100A9 0.781 PFN1 PGLYRP2 TAGLN2 TLN1 0.781 CLU IGFBP6 MST1 PGLYRP2 0.781 MST1 PFN1 SEPP1 VCAM1 0.781 CLU IGFBP6 S100A8 TLN1 0.781 CLU MST1 PGLYRP2 S100A9 0.781 APOA1 MST1 TAGLN2 VASN 0.781 CD14 CD163 CLU IGFBP6 0.781 APOA4 PGLYRP2 S100A8 TAGLN2 0.780 APOA4 CPN2 S100A8 TAGLN2 0.780 CLU PFN1 S100A9 VASN 0.780 MST1 PFN1 S100A9 TLN1 0.780 APOA1 IGFBP6 MST1 PFN1 0.780 CD163 CLU MST1 SEPP1 0.779 APOA4 CD163 CPN2 IGFBP6 0.779 CLU SEPP1 TAGLN2 VCAM1 0.779 CLU MST1 PFN1 TAGLN2 0.779 APOA1 PGLYRP2 S100A9 TAGLN2 0.779 MST1 S100A9 TLN1 VASN 0.779 MST1 S100A8 TAGLN2 TLN1 0.779 APOA4 CLU S100A8 TAGLN2 0.779 APOA1 APOA4 CD14 TAGLN2 0.779 MST1 S100A8 S100A9 VASN 0.778 PFN1 S100A8 TLN1 VASN 0.778 CLU MST1 PGLYRP2 S100A8 0.778 APOA1 CD163 PGLYRP2 TLN1 0.778 APOA1 S100A9 SEPP1 TAGLN2 0.778 IGFBP6 PFN1 SEPP1 VCAM1 0.778 APOA4 TLN1 VASN VCAM1 0.778 APOA4 IGFBP6 TLN1 VASN 0.777 IGFBP6 PGLYRP2 TLN1 VCAM1 0.777 APOA4 PGLYRP2 S100A9 TLN1 0.777 CD163 CPN2 SEPP1 TAGLN2 0.777 CPN2 S100A8 TAGLN2 VASN 0.776 CD14 CD163 S100A8 TAGLN2 0.776 APOA4 CD163 TAGLN2 VCAM1 0.776 CLU PFN1 TLN1 VCAM1 0.775 APOA4 TAGLN2 TLN1 VCAM1 0.775 PGLYRP2 S100A8 VASN VCAM1 0.775 CLU IGFBP6 MST1 S100A8 0.775 IGFBP6 MST1 PFN1 TAGLN2 0.775 CLU PFN1 PGLYRP2 S100A9 0.775 CD163 PGLYRP2 S100A8 TLN1 0.775 CLU MST1 S100A9 VCAM1 0.774 CLU MST1 S100A8 VASN 0.774 CLU PGLYRP2 VASN VCAM1 0.774 APOA1 CD163 TLN1 VCAM1 0.774 CD163 CPN2 S100A9 TAGLN2 0.774 CPN2 S100A9 TAGLN2 TLN1 0.774 APOA4 PGLYRP2 S100A8 TLN1 0.774 APOA1 CPN2 PGLYRP2 TAGLN2 0.774 APOA4 CLU PGLYRP2 TLN1 0.774 APOA4 CD163 CPN2 PFN1 0.773 APOA4 MST1 TAGLN2 VASN 0.773 APOA1 CPN2 IGFBP6 S100A9 0.773 CLU IGFBP6 PGLYRP2 TLN1 0.773 CPN2 PGLYRP2 SEPP1 VCAM1 0.773 CD14 SEPP1 TAGLN2 VCAM1 0.773 APOA1 CD14 CPN2 SEPP1 0.773 CD163 S100A8 TAGLN2 VCAM1 0.773 APOA4 CD14 MST1 TAGLN2 0.773 CLU PGLYRP2 TAGLN2 TLN1 0.773 CD14 S100A8 S100A9 SEPP1 0.772 CD163 MST1 PGLYRP2 SEPP1 0.772 S100A8 TAGLN2 TLN1 VCAM1 0.772 CLU MST1 PFN1 TLN1 0.772 CLU IGFBP6 MST1 VASN 0.772 CD14 CLU VASN VCAM1 0.771 APOA4 IGFBP6 S100A9 TAGLN2 0.771 CLU MST1 SEPP1 VASN 0.771 CD163 CLU MST1 VCAM1 0.771 APOA1 MST1 PFN1 VASN 0.771 CD14 PGLYRP2 SEPP1 TLN1 0.771 APOA1 CPN2 IGFBP6 S100A8 0.771 CLU MST1 S100A9 VASN 0.770 APOA4 CPN2 S100A9 TAGLN2 0.770 CLU CPN2 PFN1 S100A9 0.770 CD14 PGLYRP2 S100A8 S100A9 0.770 CD14 CLU PGLYRP2 SEPP1 0.770 IGFBP6 S100A9 TAGLN2 TLN1 0.770 APOA4 MST1 PFN1 VCAM1 0.770 CLU PFN1 S100A9 TLN1 0.770 CPN2 SEPP1 TAGLN2 VCAM1 0.770 CPN2 IGFBP6 S100A8 SEPP1 0.769 APOA4 PFN1 SEPP1 VCAM1 0.769 CPN2 IGFBP6 S100A9 SEPP1 0.769 CD14 CLU IGFBP6 S100A8 0.769 CD14 PGLYRP2 S100A9 TLN1 0.769 CD14 CD163 S100A9 TAGLN2 0.769 CPN2 PGLYRP2 S100A8 VCAM1 0.769 CLU CPN2 IGFBP6 S100A9 0.768 APOA1 CD163 SEPP1 VASN 0.768 CD14 PFN1 SEPP1 TAGLN2 0.768 MST1 SEPP1 TLN1 VASN 0.768 CD163 S100A8 SEPP1 TLN1 0.768 APOA4 PGLYRP2 S100A9 TAGLN2 0.767 IGFBP6 MST1 TLN1 VASN 0.767 CD163 CLU SEPP1 VASN 0.767 PFN1 S100A9 TAGLN2 TLN1 0.767 CD14 S100A8 S100A9 VASN 0.767 CLU IGFBP6 S100A9 TLN1 0.767 MST1 PGLYRP2 SEPP1 TLN1 0.767 APOA4 CD14 CPN2 VCAM1 0.767 CD163 CLU IGFBP6 PGLYRP2 0.766 APOA4 PGLYRP2 VASN VCAM1 0.766 CD163 MST1 S100A9 TAGLN2 0.766 APOA4 CD14 CLU CPN2 0.766 APOA4 CLU S100A9 TAGLN2 0.766 APOA4 MST1 TAGLN2 VCAM1 0.766 APOA1 CD14 CPN2 S100A8 0.766 APOA4 IGFBP6 PFN1 VCAM1 0.766 CD163 PFN1 SEPP1 VCAM1 0.766 CD14 CLU IGFBP6 SEPP1 0.766 CPN2 IGFBP6 TAGLN2 VASN 0.766 CLU PGLYRP2 SEPP1 TLN1 0.765 CD14 S100A9 TAGLN2 VCAM1 0.765 CD14 CLU CPN2 VCAM1 0.765 CD14 PGLYRP2 S100A8 TLN1 0.764 CD163 IGFBP6 PGLYRP2 SEPP1 0.764 CLU S100A8 S100A9 VASN 0.764 CD163 IGFBP6 PGLYRP2 TLN1 0.764 CD14 MST1 S100A9 TAGLN2 0.764 CLU IGFBP6 MST1 SEPP1 0.764 APOA4 PFN1 PGLYRP2 TAGLN2 0.764 APOA1 CD163 IGFBP6 MST1 0.763 APOA4 CD14 CLU S100A9 0.763 CLU PGLYRP2 TLN1 VASN 0.763 MST1 PFN1 SEPP1 TAGLN2 0.763 CPN2 IGFBP6 S100A9 VASN 0.763 CD163 IGFBP6 MST1 SEPP1 0.763 CPN2 S100A9 TAGLN2 VASN 0.763 CLU MST1 TAGLN2 VASN 0.763 CD163 IGFBP6 TAGLN2 TLN1 0.763 APOA1 CD14 CLU IGFBP6 0.762 CLU PGLYRP2 S100A8 TAGLN2 0.762 APOA1 IGFBP6 TAGLN2 VCAM1 0.762 APOA4 CPN2 SEPP1 TLN1 0.762 CLU IGFBP6 MST1 S100A9 0.762 IGFBP6 MST1 PGLYRP2 VASN 0.762 CD14 CD163 PGLYRP2 TLN1 0.762 CD14 CLU PGLYRP2 S100A8 0.762 CD14 CLU IGFBP6 PGLYRP2 0.762 CPN2 IGFBP6 S100A8 VASN 0.762 APOA1 PGLYRP2 SEPP1 VCAM1 0.761 APOA1 SEPP1 TAGLN2 VCAM1 0.761 CD14 IGFBP6 S100A8 S100A9 0.761 APOA1 CPN2 S100A8 TAGLN2 0.761 APOA1 CD163 CLU VASN 0.761 CLU TAGLN2 TLN1 VCAM1 0.761 APOA1 APOA4 PGLYRP2 TAGLN2 0.760 CLU CPN2 S100A8 S100A9 0.760 CPN2 PGLYRP2 S100A9 VASN 0.760 APOA4 CPN2 TLN1 VCAM1 0.760 CLU IGFBP6 PFN1 TLN1 0.760 CPN2 PGLYRP2 S100A8 VASN 0.760 CPN2 TLN1 VASN VCAM1 0.760 CLU TLN1 VASN VCAM1 0.759 APOA4 CD163 CPN2 VASN 0.759 APOA1 CLU IGFBP6 MST1 0.759 CD14 S100A9 TLN1 VASN 0.759 CD14 IGFBP6 PGLYRP2 TLN1 0.759 CLU PGLYRP2 SEPP1 TAGLN2 0.759 APOA4 CLU MST1 TLN1 0.759 APOA1 CLU MST1 PGLYRP2 0.759 CLU IGFBP6 S100A9 VCAM1 0.758 APOA4 PFN1 TLN1 VCAM1 0.758 CD163 S100A8 TAGLN2 TLN1 0.758 APOA4 PGLYRP2 TLN1 VASN 0.758 APOA1 CD163 PGLYRP2 SEPP1 0.758 CD14 CD163 CLU PGLYRP2 0.758 CLU MST1 TLN1 VASN 0.758 CPN2 PGLYRP2 SEPP1 VASN 0.758 APOA4 IGFBP6 TLN1 VCAM1 0.758 CD14 CD163 CLU S100A9 0.758 PFN1 S100A9 TLN1 VASN 0.758 CD163 PGLYRP2 TLN1 VCAM1 0.758 CD14 S100A8 TLN1 VASN 0.757 CLU PGLYRP2 S100A9 TAGLN2 0.757 APOA1 CD163 PGLYRP2 S100A9 0.757 APOA4 CLU TLN1 VCAM1 0.757 CPN2 S100A8 SEPP1 TLN1 0.757 APOA1 PFN1 PGLYRP2 SEPP1 0.757 APOA1 PGLYRP2 TLN1 VCAM1 0.757 APOA4 PFN1 TAGLN2 VCAM1 0.757 CD14 CD163 CLU SEPP1 0.757 MST1 S100A9 TAGLN2 VCAM1 0.757 APOA4 CD14 CLU IGFBP6 0.756 CLU IGFBP6 PGLYRP2 VCAM1 0.756 APOA1 PFN1 PGLYRP2 TAGLN2 0.756 PGLYRP2 SEPP1 TLN1 VASN 0.756 APOA4 S100A8 S100A9 VASN 0.756 APOA4 CPN2 PGLYRP2 VASN 0.756 CPN2 PGLYRP2 S100A8 SEPP1 0.756 PGLYRP2 SEPP1 TLN1 VCAM1 0.756 CD163 IGFBP6 MST1 TAGLN2 0.756 APOA4 CD163 CLU TAGLN2 0.755 CD14 CLU S100A9 VASN 0.755 APOA1 CPN2 S100A9 TAGLN2 0.755 APOA1 MST1 PGLYRP2 TLN1 0.755 CD14 CLU PGLYRP2 VCAM1 0.755 CD163 CPN2 PGLYRP2 S100A9 0.755 CD163 CLU S100A9 TAGLN2 0.755 CD14 MST1 PGLYRP2 VASN 0.754 APOA1 APOA4 VASN VCAM1 0.754 IGFBP6 PGLYRP2 TLN1 VASN 0.754 IGFBP6 S100A8 TLN1 VASN 0.754 CD14 MST1 PGLYRP2 TLN1 0.754 PGLYRP2 S100A9 TLN1 VCAM1 0.754 APOA1 CD163 IGFBP6 S100A8 0.754 CD14 S100A8 TAGLN2 TLN1 0.753 PGLYRP2 S100A8 TLN1 VCAM1 0.753 CD163 CPN2 PGLYRP2 SEPP1 0.753 IGFBP6 MST1 PGLYRP2 TLN1 0.753 CD14 CLU PGLYRP2 VASN 0.753 APOA4 S100A8 SEPP1 TLN1 0.752 APOA1 PGLYRP2 SEPP1 TAGLN2 0.752 APOA4 CD14 SEPP1 TLN1 0.752 CLU MST1 SEPP1 TLN1 0.752 IGFBP6 PGLYRP2 SEPP1 VCAM1 0.751 APOA1 CD14 CLU S100A9 0.751 CD14 S100A9 VASN VCAM1 0.751 CLU IGFBP6 S100A8 VCAM1 0.751 CD163 S100A9 SEPP1 TLN1 0.751 APOA4 CLU MST1 PGLYRP2 0.751 IGFBP6 MST1 SEPP1 VASN 0.751 APOA1 CD163 MST1 PGLYRP2 0.751 CPN2 S100A9 TLN1 VCAM1 0.751 CD14 IGFBP6 TLN1 VASN 0.751 PGLYRP2 SEPP1 TAGLN2 TLN1 0.751 APOA4 MST1 SEPP1 TLN1 0.751 CD163 CLU IGFBP6 S100A8 0.750 APOA4 CD163 S100A8 TLN1 0.750 CD14 PGLYRP2 SEPP1 VASN 0.750 APOA4 MST1 TLN1 VASN 0.750 PFN1 PGLYRP2 SEPP1 TLN1 0.750 CD163 IGFBP6 MST1 PFN1 0.750 APOA4 CPN2 PGLYRP2 S100A9 0.750 CD163 IGFBP6 PFN1 TAGLN2 0.749 CLU CPN2 S100A8 TAGLN2 0.749 CD14 S100A8 VASN VCAM1 0.749 CD14 MST1 S100A8 S100A9 0.749 CD14 CLU MST1 S100A9 0.749 APOA4 CD163 PGLYRP2 S100A9 0.749 CPN2 TAGLN2 TLN1 VCAM1 0.749 APOA1 CLU PFN1 PGLYRP2 0.749 APOA1 APOA4 TAGLN2 VCAM1 0.749 APOA1 CPN2 PGLYRP2 SEPP1 0.749 APOA1 CD14 PGLYRP2 VASN 0.748 APOA1 PGLYRP2 TLN1 VASN 0.748 APOA1 CD14 IGFBP6 TLN1 0.748 APOA4 CLU PFN1 PGLYRP2 0.748 APOA4 S100A8 TAGLN2 TLN1 0.748 CD14 CLU S100A8 VASN 0.748 CD163 CPN2 PGLYRP2 S100A8 0.747 CD14 PGLYRP2 TLN1 VCAM1 0.747 APOA4 CD14 VASN VCAM1 0.747 APOA1 IGFBP6 PFN1 VCAM1 0.747 CD14 CLU CPN2 SEPP1 0.747 CD14 IGFBP6 MST1 VASN 0.747 APOA1 CLU MST1 TAGLN2 0.747 CD14 CD163 CLU S100A8 0.747 CD14 SEPP1 TLN1 VASN 0.747 PGLYRP2 S100A9 SEPP1 TLN1 0.747 APOA1 CD163 IGFBP6 PGLYRP2 0.747 APOA1 PFN1 SEPP1 VCAM1 0.746 APOA1 APOA4 CPN2 PGLYRP2 0.746 CD14 IGFBP6 PGLYRP2 SEPP1 0.746 APOA4 PGLYRP2 TAGLN2 TLN1 0.746 CD163 CPN2 S100A8 VASN 0.746 CD14 PGLYRP2 S100A9 VASN 0.746 CD14 IGFBP6 PGLYRP2 VASN 0.745 APOA4 CD14 PGLYRP2 S100A9 0.745 APOA1 CLU IGFBP6 TLN1 0.745 IGFBP6 S100A8 TLN1 VCAM1 0.745 APOA1 CD163 MST1 S100A8 0.745 CD14 CLU IGFBP6 VASN 0.745 CPN2 PGLYRP2 S100A9 VCAM1 0.745 APOA1 CPN2 PGLYRP2 VASN 0.745 IGFBP6 PGLYRP2 SEPP1 TLN1 0.745 CLU PFN1 PGLYRP2 TAGLN2 0.745 IGFBP6 PGLYRP2 S100A9 VCAM1 0.745 CD163 CLU IGFBP6 S100A9 0.745 CLU PFN1 PGLYRP2 SEPP1 0.745 APOA1 CPN2 S100A8 TLN1 0.745 APOA1 MST1 PGLYRP2 VASN 0.744 CLU CPN2 PGLYRP2 SEPP1 0.744 APOA1 CD14 CLU PGLYRP2 0.744 APOA1 IGFBP6 MST1 TLN1 0.744 CPN2 S100A8 VASN VCAM1 0.744 APOA1 IGFBP6 PGLYRP2 VASN 0.744 APOA4 CD163 S100A9 TLN1 0.744 MST1 PGLYRP2 SEPP1 VASN 0.744 CLU S100A9 TLN1 VCAM1 0.744 APOA4 CD163 CPN2 TAGLN2 0.744 APOA1 CD163 CPN2 PGLYRP2 0.743 CLU CPN2 S100A9 TAGLN2 0.743 APOA1 CLU MST1 S100A9 0.743 CD163 PGLYRP2 S100A9 SEPP1 0.743 APOA1 CD163 CPN2 VASN 0.742 IGFBP6 MST1 PGLYRP2 SEPP1 0.742 CLU PGLYRP2 S100A8 TLN1 0.742 CD163 IGFBP6 SEPP1 TLN1 0.742 CD14 CD163 CLU VCAM1 0.742 APOA1 CD163 IGFBP6 TLN1 0.742 APOA1 CLU MST1 S100A8 0.742 CD163 IGFBP6 MST1 PGLYRP2 0.742 APOA4 IGFBP6 MST1 PGLYRP2 0.742 PGLYRP2 S100A8 SEPP1 TLN1 0.742 CLU CPN2 PFN1 VCAM1 0.741 IGFBP6 PGLYRP2 S100A9 VASN 0.741 APOA1 CD14 CD163 CLU 0.741 APOA4 CD14 CD163 TLN1 0.741 APOA4 CLU IGFBP6 VCAM1 0.741 IGFBP6 MST1 TAGLN2 VCAM1 0.741 APOA1 CD14 PGLYRP2 S100A9 0.741 APOA1 CD14 VASN VCAM1 0.741 APOA4 CLU PGLYRP2 TAGLN2 0.741 CLU S100A8 S100A9 SEPP1 0.741 CD163 CLU VASN VCAM1 0.741 CD14 SEPP1 VASN VCAM1 0.740 APOA4 IGFBP6 MST1 VCAM1 0.740 IGFBP6 MST1 S100A8 VASN 0.740 APOA1 CPN2 PGLYRP2 S100A8 0.740 IGFBP6 MST1 PGLYRP2 VCAM1 0.740 APOA4 CPN2 S100A8 TLN1 0.740 APOA1 MST1 PGLYRP2 SEPP1 0.740 APOA4 CD14 CLU PGLYRP2 0.740 PGLYRP2 S100A8 TLN1 VASN 0.740 CD14 CD163 MST1 PFN1 0.740 APOA4 CD14 CLU VCAM1 0.740 APOA1 CD14 IGFBP6 PGLYRP2 0.740 APOA4 CPN2 PFN1 TLN1 0.739 IGFBP6 PFN1 TAGLN2 VCAM1 0.739 APOA1 CPN2 PGLYRP2 S100A9 0.739 CD163 IGFBP6 PGLYRP2 VCAM1 0.739 CD14 CLU MST1 S100A8 0.739 IGFBP6 PGLYRP2 SEPP1 VASN 0.739 APOA4 CLU IGFBP6 MST1 0.739 APOA4 CD163 IGFBP6 MST1 0.739 IGFBP6 S100A9 TLN1 VASN 0.738 APOA1 APOA4 PGLYRP2 TLN1 0.738 APOA4 S100A9 TAGLN2 TLN1 0.738 APOA1 CLU PGLYRP2 TAGLN2 0.738 APOA4 CPN2 PGLYRP2 S100A8 0.738 APOA1 CD14 CLU VCAM1 0.738 CPN2 IGFBP6 SEPP1 TAGLN2 0.738 MST1 SEPP1 TAGLN2 TLN1 0.738 CD163 MST1 PGLYRP2 TLN1 0.738 APOA1 CLU TLN1 VCAM1 0.738 CD163 CPN2 VASN VCAM1 0.737 APOA1 APOA4 CD163 TLN1 0.737 APOA4 CD14 CD163 CLU 0.737 APOA4 CD163 TLN1 VCAM1 0.737 APOA1 CD14 CLU SEPP1 0.737 APOA4 CLU PFN1 VCAM1 0.737 APOA4 CPN2 PGLYRP2 VCAM1 0.737 IGFBP6 PGLYRP2 S100A8 VASN 0.737 MST1 PGLYRP2 S100A8 VASN 0.737 APOA4 IGFBP6 SEPP1 TLN1 0.736 APOA1 IGFBP6 MST1 VASN 0.736 MST1 PGLYRP2 TLN1 VCAM1 0.736 CD14 CD163 PGLYRP2 S100A8 0.736 APOA4 CPN2 S100A9 TLN1 0.736 CLU PGLYRP2 S100A9 TLN1 0.736 APOA4 CD14 CLU S100A8 0.736 APOA1 CPN2 PGLYRP2 VCAM1 0.736 APOA1 CD163 MST1 S100A9 0.736 CD163 S100A9 TAGLN2 VCAM1 0.736 APOA4 CD163 MST1 TLN1 0.735 APOA1 CLU CPN2 IGFBP6 0.735 CD14 IGFBP6 PGLYRP2 VCAM1 0.735 CPN2 IGFBP6 PFN1 SEPP1 0.735 APOA4 CD14 IGFBP6 PGLYRP2 0.735 APOA1 PFN1 PGLYRP2 TLN1 0.735 PGLYRP2 S100A9 TLN1 VASN 0.734 CLU S100A8 VASN VCAM1 0.734 APOA4 CD163 CPN2 PGLYRP2 0.734 APOA4 CD14 CD163 S100A9 0.734 CD163 MST1 S100A8 SEPP1 0.734 APOA1 CLU CPN2 PGLYRP2 0.734 APOA1 CD163 MST1 VCAM1 0.734 APOA4 S100A9 SEPP1 TLN1 0.734 APOA1 CLU MST1 PFN1 0.734 IGFBP6 PGLYRP2 S100A8 TLN1 0.733 CD14 CLU S100A8 SEPP1 0.733 CD163 S100A9 TAGLN2 TLN1 0.733 APOA1 CLU MST1 VCAM1 0.733 MST1 PGLYRP2 SEPP1 VCAM1 0.733 APOA4 CD14 PGLYRP2 VASN 0.733 CD163 CPN2 PGLYRP2 VCAM1 0.732 APOA1 IGFBP6 MST1 PGLYRP2 0.732 APOA4 SEPP1 TAGLN2 TLN1 0.732 CD14 IGFBP6 MST1 PGLYRP2 0.732 MST1 PGLYRP2 S100A9 VASN 0.732 APOA1 TLN1 VASN VCAM1 0.731 CD163 IGFBP6 S100A8 TLN1 0.731 CLU IGFBP6 TAGLN2 TLN1 0.731 CLU MST1 TAGLN2 TLN1 0.731 IGFBP6 S100A8 SEPP1 TLN1 0.731 S100A9 TAGLN2 TLN1 VCAM1 0.731 APOA1 MST1 SEPP1 TAGLN2 0.731 IGFBP6 MST1 PGLYRP2 S100A9 0.731 CD163 IGFBP6 TAGLN2 VCAM1 0.731 CD163 MST1 PGLYRP2 S100A8 0.731 CD14 PGLYRP2 S100A8 VASN 0.730 CD163 CPN2 PFN1 VCAM1 0.730 CD163 MST1 SEPP1 TLN1 0.730 APOA1 CD163 MST1 TLN1 0.730 APOA4 CLU MST1 S100A9 0.730 IGFBP6 MST1 S100A8 TLN1 0.730 CD14 S100A9 TAGLN2 TLN1 0.730 APOA4 IGFBP6 MST1 VASN 0.730 CD14 CLU S100A9 SEPP1 0.730 CPN2 PFN1 SEPP1 TLN1 0.730 IGFBP6 PGLYRP2 S100A9 TLN1 0.730 APOA4 MST1 PGLYRP2 SEPP1 0.730 IGFBP6 MST1 S100A9 VASN 0.729 S100A8 SEPP1 VASN VCAM1 0.729 APOA4 CLU MST1 S100A8 0.729 APOA1 CD163 MST1 SEPP1 0.729 CD14 CD163 IGFBP6 PGLYRP2 0.729 APOA4 CLU S100A8 S100A9 0.729 APOA4 CD163 IGFBP6 PGLYRP2 0.729 CLU S100A9 VASN VCAM1 0.729 APOA1 IGFBP6 PGLYRP2 SEPP1 0.729 SEPP1 TLN1 VASN VCAM1 0.729 APOA1 MST1 PGLYRP2 S100A9 0.729 APOA1 CD163 SEPP1 TLN1 0.728 PFN1 SEPP1 TLN1 VCAM1 0.728 APOA4 IGFBP6 PGLYRP2 VCAM1 0.728 CLU MST1 S100A8 SEPP1 0.728 CLU IGFBP6 PGLYRP2 VASN 0.728 APOA1 CD163 CLU PGLYRP2 0.728 APOA1 CLU MST1 TLN1 0.727 CPN2 S100A9 VASN VCAM1 0.727 APOA4 MST1 S100A8 TLN1 0.727 CD14 CLU SEPP1 VASN 0.727 APOA1 IGFBP6 PGLYRP2 TLN1 0.727 IGFBP6 MST1 SEPP1 VCAM1 0.727 APOA1 CD14 CD163 IGFBP6 0.727 IGFBP6 MST1 PGLYRP2 S100A8 0.727 APOA4 CD14 PGLYRP2 S100A8 0.727 APOA1 CD163 VASN VCAM1 0.726 APOA1 APOA4 CD14 CLU 0.726 IGFBP6 PGLYRP2 S100A9 SEPP1 0.726 APOA4 CPN2 IGFBP6 TAGLN2 0.726 APOA1 APOA4 CD14 TLN1 0.726 APOA4 MST1 PGLYRP2 VASN 0.726 IGFBP6 MST1 PFN1 VCAM1 0.726 APOA4 CD163 PFN1 VCAM1 0.726 CD14 CD163 PGLYRP2 SEPP1 0.726 APOA1 CD14 IGFBP6 MST1 0.726 S100A8 TAGLN2 TLN1 VASN 0.725 IGFBP6 PGLYRP2 S100A8 SEPP1 0.725 APOA4 IGFBP6 PGLYRP2 S100A9 0.725 CD163 IGFBP6 S100A8 SEPP1 0.725 APOA4 CLU SEPP1 TLN1 0.725 CLU IGFBP6 PGLYRP2 SEPP1 0.725 APOA1 CD14 MST1 PGLYRP2 0.725 APOA4 IGFBP6 PGLYRP2 VASN 0.725 APOA4 IGFBP6 S100A9 VCAM1 0.725 CPN2 S100A8 TLN1 VASN 0.724 APOA4 IGFBP6 PGLYRP2 S100A8 0.724 CD14 PGLYRP2 S100A9 VCAM1 0.724 APOA4 SEPP1 TLN1 VCAM1 0.724 APOA1 S100A8 TAGLN2 VASN 0.724 CLU IGFBP6 SEPP1 VCAM1 0.724 APOA4 S100A8 TAGLN2 VASN 0.724 CD14 CD163 SEPP1 TLN1 0.723 MST1 S100A8 SEPP1 VASN 0.723 APOA4 CD14 CLU SEPP1 0.723 CPN2 PGLYRP2 S100A9 SEPP1 0.723 APOA1 CD163 S100A8 TLN1 0.723 APOA1 CPN2 IGFBP6 VASN 0.723 APOA1 IGFBP6 MST1 S100A9 0.723 APOA1 PGLYRP2 S100A9 VCAM1 0.723 CD163 S100A9 VASN VCAM1 0.723 CD163 IGFBP6 PFN1 VCAM1 0.722 APOA1 IGFBP6 PGLYRP2 VCAM1 0.722 APOA1 CD14 IGFBP6 S100A9 0.722 CD163 MST1 S100A9 SEPP1 0.722 APOA4 PGLYRP2 S100A9 VCAM1 0.722 APOA4 CD163 MST1 PGLYRP2 0.722 APOA1 CD163 S100A9 VASN 0.722 APOA4 CD163 VASN VCAM1 0.722 CD163 CPN2 SEPP1 VASN 0.722 APOA4 CLU MST1 VASN 0.722 APOA4 CPN2 TAGLN2 TLN1 0.721 SEPP1 TAGLN2 TLN1 VCAM1 0.721 APOA4 CLU S100A8 TLN1 0.721 APOA4 CD163 PFN1 TAGLN2 0.721 APOA1 IGFBP6 MST1 S100A8 0.721 CD163 SEPP1 VASN VCAM1 0.721 APOA4 CD14 IGFBP6 MST1 0.721 APOA4 MST1 SEPP1 VCAM1 0.721 PFN1 SEPP1 TAGLN2 VCAM1 0.721 APOA1 PGLYRP2 SEPP1 VASN 0.721 CD14 PGLYRP2 S100A9 SEPP1 0.721 APOA1 CPN2 IGFBP6 SEPP1 0.720 CLU PFN1 SEPP1 VCAM1 0.720 APOA1 CD14 IGFBP6 VASN 0.720 IGFBP6 PGLYRP2 S100A8 VCAM1 0.720 APOA4 CLU VASN VCAM1 0.720 APOA1 CLU IGFBP6 PGLYRP2 0.719 APOA1 IGFBP6 PGLYRP2 S100A9 0.719 APOA1 MST1 S100A8 TLN1 0.719 APOA1 CD163 PGLYRP2 S100A8 0.719 MST1 S100A9 TAGLN2 TLN1 0.719 CD14 MST1 PGLYRP2 VCAM1 0.719 CPN2 SEPP1 TAGLN2 TLN1 0.719 CLU CPN2 IGFBP6 VASN 0.719 APOA4 S100A8 TLN1 VASN 0.719 APOA1 CD163 CLU IGFBP6 0.719 CLU CPN2 IGFBP6 SEPP1 0.718 MST1 PGLYRP2 S100A8 SEPP1 0.718 APOA1 CPN2 TLN1 VCAM1 0.718 APOA4 CPN2 IGFBP6 PFN1 0.718 MST1 S100A9 SEPP1 VASN 0.718 APOA4 CD14 PGLYRP2 SEPP1 0.718 MST1 PGLYRP2 S100A9 SEPP1 0.717 CD14 CD163 MST1 PGLYRP2 0.717 APOA1 CD14 PGLYRP2 SEPP1 0.717 CLU IGFBP6 TAGLN2 VASN 0.717 CD14 IGFBP6 PGLYRP2 S100A9 0.717 APOA4 IGFBP6 PGLYRP2 SEPP1 0.717 CD163 PGLYRP2 S100A8 SEPP1 0.717 CD14 CD163 MST1 TAGLN2 0.716 APOA1 CD14 CD163 TLN1 0.716 APOA4 CD14 CD163 PGLYRP2 0.716 CLU IGFBP6 TLN1 VASN 0.716 APOA4 IGFBP6 MST1 SEPP1 0.716 APOA4 CPN2 PGLYRP2 SEPP1 0.716 S100A8 SEPP1 TLN1 VASN 0.716 CD14 PGLYRP2 SEPP1 VCAM1 0.716 APOA4 CD14 S100A8 TLN1 0.716 APOA1 CLU TAGLN2 VCAM1 0.716 APOA1 PGLYRP2 TAGLN2 TLN1 0.716 APOA4 CD14 S100A9 TLN1 0.716 APOA1 CLU S100A8 TAGLN2 0.716 APOA4 CD14 CLU VASN 0.715 APOA4 MST1 PGLYRP2 VCAM1 0.715 APOA1 CLU MST1 VASN 0.715 APOA4 CD14 MST1 TLN1 0.715 CD14 IGFBP6 SEPP1 VASN 0.715 APOA1 MST1 S100A8 VASN 0.715 CD14 MST1 S100A9 VASN 0.715 CD163 PGLYRP2 S100A8 VCAM1 0.715 APOA1 CD163 S100A8 VASN 0.715 APOA4 CD163 PGLYRP2 S100A8 0.715 CD163 SEPP1 TLN1 VCAM1 0.715 MST1 PGLYRP2 S100A9 TLN1 0.714 APOA4 CD163 IGFBP6 S100A9 0.714 CD163 S100A8 VASN VCAM1 0.714 APOA1 MST1 PGLYRP2 S100A8 0.713 CPN2 IGFBP6 SEPP1 VASN 0.713 APOA1 CD14 PGLYRP2 S100A8 0.713 APOA4 S100A8 TLN1 VCAM1 0.713 CLU S100A8 TAGLN2 VASN 0.713 APOA4 CLU S100A9 TLN1 0.712 CD14 IGFBP6 S100A8 TLN1 0.712 APOA1 CLU IGFBP6 VCAM1 0.712 CD14 CLU S100A8 VCAM1 0.712 CD14 MST1 PGLYRP2 S100A9 0.712 APOA1 IGFBP6 PGLYRP2 S100A8 0.712 APOA1 SEPP1 VASN VCAM1 0.712 APOA4 MST1 S100A9 TLN1 0.712 CLU IGFBP6 PGLYRP2 S100A9 0.712 APOA4 CD14 IGFBP6 S100A9 0.712 APOA4 CLU IGFBP6 PGLYRP2 0.711 CD14 MST1 PFN1 VCAM1 0.711 CPN2 SEPP1 TLN1 VCAM1 0.711 IGFBP6 TAGLN2 TLN1 VCAM1 0.711 IGFBP6 MST1 S100A9 VCAM1 0.711 CLU IGFBP6 PFN1 VASN 0.711 CD14 CD163 PGLYRP2 VCAM1 0.711 APOA4 S100A9 TAGLN2 VASN 0.711 MST1 PGLYRP2 S100A9 VCAM1 0.711 APOA1 IGFBP6 S100A8 TLN1 0.711 APOA1 IGFBP6 S100A9 VCAM1 0.711 APOA4 CPN2 IGFBP6 VASN 0.711 APOA1 APOA4 CPN2 IGFBP6 0.711 IGFBP6 TAGLN2 TLN1 VASN 0.711 CD163 PGLYRP2 S100A9 VCAM1 0.710 APOA1 CD14 S100A8 TLN1 0.710 MST1 PGLYRP2 S100A8 TLN1 0.710 APOA4 IGFBP6 TAGLN2 TLN1 0.710 APOA4 IGFBP6 MST1 S100A8 0.710 CD14 IGFBP6 S100A9 VASN 0.710 APOA1 CLU PFN1 VCAM1 0.710 APOA1 CD14 CD163 PGLYRP2 0.709 APOA4 CD14 MST1 PGLYRP2 0.709 APOA4 CD163 CLU VASN 0.709 APOA1 CD14 CLU VASN 0.709 APOA1 S100A8 VASN VCAM1 0.708 IGFBP6 PFN1 TAGLN2 VASN 0.708 APOA4 S100A9 TLN1 VASN 0.708 CD14 MST1 S100A8 VASN 0.708 IGFBP6 PFN1 TLN1 VCAM1 0.708 APOA1 CD163 PGLYRP2 VCAM1 0.708 S100A9 SEPP1 TLN1 VASN 0.707 APOA4 CLU CPN2 IGFBP6 0.707 APOA1 APOA4 IGFBP6 PGLYRP2 0.707 APOA4 CD14 TLN1 VCAM1 0.707 APOA4 CD14 MST1 VASN 0.707 APOA1 MST1 S100A9 TLN1 0.707 APOA1 MST1 S100A9 VASN 0.707 APOA4 CD14 S100A9 VASN 0.707 APOA4 IGFBP6 S100A8 VCAM1 0.707 IGFBP6 S100A8 SEPP1 VCAM1 0.707 IGFBP6 MST1 S100A8 SEPP1 0.706 APOA4 CD14 IGFBP6 SEPP1 0.706 CD163 MST1 PGLYRP2 VCAM1 0.706 CD163 CLU CPN2 VASN 0.706 CD163 IGFBP6 TLN1 VCAM1 0.706 APOA4 CD163 CLU IGFBP6 0.706 APOA1 S100A9 TAGLN2 VASN 0.706 CD14 MST1 PGLYRP2 SEPP1 0.706 APOA4 PFN1 TAGLN2 TLN1 0.706 IGFBP6 MST1 S100A8 VCAM1 0.706 APOA4 IGFBP6 MST1 S100A9 0.705 APOA4 CLU MST1 SEPP1 0.705 CLU MST1 S100A9 SEPP1 0.705 APOA4 PGLYRP2 S100A8 VCAM1 0.705 APOA4 PFN1 SEPP1 TLN1 0.705 APOA1 MST1 SEPP1 VASN 0.705 APOA4 CD14 CD163 IGFBP6 0.705 APOA4 CPN2 TLN1 VASN 0.705 APOA4 SEPP1 VASN VCAM1 0.705 APOA4 MST1 TLN1 VCAM1 0.705 IGFBP6 MST1 SEPP1 TLN1 0.705 APOA4 CD163 MST1 SEPP1 0.705 MST1 PGLYRP2 S100A8 VCAM1 0.704 MST1 SEPP1 TLN1 VCAM1 0.704 CD163 CPN2 S100A9 VASN 0.704 APOA4 CD163 IGFBP6 S100A8 0.704 CPN2 S100A9 TLN1 VASN 0.704 CD14 IGFBP6 SEPP1 TLN1 0.704 CLU IGFBP6 SEPP1 TLN1 0.704 APOA1 APOA4 PGLYRP2 SEPP1 0.704 APOA1 CPN2 VASN VCAM1 0.704 APOA4 CPN2 VASN VCAM1 0.704 APOA1 PGLYRP2 S100A8 VCAM1 0.703 APOA1 IGFBP6 TAGLN2 VASN 0.703 CLU CPN2 S100A8 TLN1 0.703 APOA1 CD14 IGFBP6 SEPP1 0.703 CPN2 S100A9 SEPP1 TLN1 0.703 CLU S100A9 TAGLN2 VASN 0.703 APOA1 APOA4 CPN2 TLN1 0.703 APOA1 CD14 MST1 TLN1 0.703 APOA4 MST1 PGLYRP2 S100A9 0.703 APOA1 IGFBP6 S100A9 TLN1 0.703 APOA1 IGFBP6 PFN1 VASN 0.703 CD163 CLU PGLYRP2 SEPP1 0.702 PGLYRP2 S100A8 TAGLN2 TLN1 0.702 APOA1 APOA4 IGFBP6 MST1 0.702 APOA1 PGLYRP2 S100A9 TLN1 0.702 APOA1 PGLYRP2 S100A9 VASN 0.702 APOA1 CD14 PGLYRP2 VCAM1 0.702 CLU IGFBP6 PFN1 TAGLN2 0.701 APOA4 CLU CPN2 TLN1 0.701 APOA1 CPN2 SEPP1 TLN1 0.701 CD14 IGFBP6 S100A8 VASN 0.701 APOA1 CD14 S100A9 VASN 0.701 CD14 IGFBP6 PGLYRP2 S100A8 0.701 CD14 PGLYRP2 S100A8 VCAM1 0.701 CD14 CD163 IGFBP6 SEPP1 0.700 CD163 CLU IGFBP6 SEPP1 0.700 APOA1 CD14 CLU S100A8 0.700 CD163 CLU S100A9 VASN 0.700 CD14 MST1 SEPP1 VASN 0.700 APOA4 CD14 IGFBP6 VASN 0.700 CD14 MST1 PGLYRP2 S100A8 0.700 APOA1 PGLYRP2 S100A8 TLN1 0.700 APOA1 MST1 PFN1 TLN1 0.700 APOA4 PGLYRP2 S100A9 VASN 0.700 CLU S100A8 TAGLN2 TLN1 0.700 PGLYRP2 S100A9 TAGLN2 TLN1 0.700 CLU S100A8 SEPP1 TLN1 0.699 S100A9 TAGLN2 TLN1 VASN 0.699 IGFBP6 PFN1 TLN1 VASN 0.699 CLU PFN1 TAGLN2 VCAM1 0.699 APOA1 CD14 CLU CPN2 0.699 APOA1 IGFBP6 S100A8 VCAM1 0.699 APOA1 CD163 IGFBP6 SEPP1 0.698 CLU IGFBP6 PGLYRP2 S100A8 0.698 APOA1 APOA4 MST1 PGLYRP2 0.698 APOA4 IGFBP6 PFN1 TLN1 0.698 APOA1 CD163 S100A9 TLN1 0.698 APOA1 MST1 TAGLN2 TLN1 0.698 APOA1 IGFBP6 PFN1 TAGLN2 0.698 APOA1 APOA4 MST1 TLN1 0.698 CD163 CPN2 TAGLN2 VCAM1 0.697 APOA1 CLU IGFBP6 S100A8 0.697 CD14 IGFBP6 MST1 VCAM1 0.697 CLU IGFBP6 S100A8 SEPP1 0.697 CLU PGLYRP2 S100A8 VASN 0.697 CLU IGFBP6 S100A9 SEPP1 0.697 IGFBP6 S100A9 TLN1 VCAM1 0.697 APOA4 CD163 S100A8 VASN 0.697 CD163 IGFBP6 MST1 VCAM1 0.697 MST1 S100A8 SEPP1 TLN1 0.697 APOA4 CD163 S100A9 VASN 0.697 CD163 CLU S100A8 VASN 0.697 APOA1 APOA4 IGFBP6 TLN1 0.697 MST1 TAGLN2 TLN1 VASN 0.697 APOA1 APOA4 CD163 PGLYRP2 0.697 CD163 IGFBP6 MST1 S100A8 0.697 APOA4 PGLYRP2 SEPP1 VASN 0.696 CLU PGLYRP2 SEPP1 VASN 0.696 APOA4 CLU IGFBP6 S100A8 0.696 APOA1 APOA4 PFN1 VCAM1 0.696 APOA1 APOA4 CD14 PGLYRP2 0.696 APOA1 PGLYRP2 SEPP1 TLN1 0.696 CLU CPN2 TAGLN2 VCAM1 0.696 APOA4 CD14 IGFBP6 S100A8 0.696 APOA1 CPN2 PFN1 TLN1 0.695 IGFBP6 PFN1 SEPP1 TAGLN2 0.695 APOA1 IGFBP6 S100A8 VASN 0.695 APOA4 CD14 IGFBP6 VCAM1 0.695 APOA1 CD14 IGFBP6 S100A8 0.695 APOA4 MST1 PFN1 TAGLN2 0.695 PGLYRP2 S100A9 SEPP1 VASN 0.694 CD163 CLU IGFBP6 VCAM1 0.694 IGFBP6 PFN1 TAGLN2 TLN1 0.694 APOA4 S100A9 TLN1 VCAM1 0.694 APOA4 CLU IGFBP6 PFN1 0.694 APOA1 APOA4 PGLYRP2 VASN 0.694 APOA1 APOA4 TLN1 VCAM1 0.694 CD14 PGLYRP2 S100A8 SEPP1 0.694 APOA4 CD163 SEPP1 VASN 0.694 CLU SEPP1 TLN1 VCAM1 0.693 APOA1 CD163 CLU CPN2 0.693 APOA4 PGLYRP2 S100A9 SEPP1 0.693 CLU PGLYRP2 S100A9 VASN 0.693 CLU PGLYRP2 SEPP1 VCAM1 0.693 APOA1 CLU S100A9 TAGLN2 0.693 APOA1 MST1 PGLYRP2 VCAM1 0.692 APOA1 CLU MST1 SEPP1 0.692 APOA1 PGLYRP2 S100A9 SEPP1 0.692 APOA4 MST1 S100A9 VASN 0.692 CLU IGFBP6 S100A8 VASN 0.692 APOA1 CLU IGFBP6 S100A9 0.692 APOA1 CLU PGLYRP2 VCAM1 0.692 APOA1 CPN2 TAGLN2 TLN1 0.692 APOA4 CD14 PGLYRP2 VCAM1 0.692 IGFBP6 SEPP1 TLN1 VCAM1 0.691 PGLYRP2 S100A8 SEPP1 VASN 0.691 CD14 CD163 S100A8 SEPP1 0.691 CD14 CD163 S100A9 SEPP1 0.691 APOA1 CLU IGFBP6 PFN1 0.691 APOA1 IGFBP6 MST1 VCAM1 0.691 APOA1 APOA4 MST1 PFN1 0.691 APOA1 S100A9 VASN VCAM1 0.691 APOA1 MST1 S100A8 SEPP1 0.691 APOA4 MST1 PGLYRP2 S100A8 0.691 APOA4 CD163 IGFBP6 SEPP1 0.690 APOA1 APOA4 S100A8 TAGLN2 0.690 CD14 IGFBP6 MST1 S100A8 0.690 APOA4 MST1 S100A8 VASN 0.690 CD14 CD163 PFN1 TAGLN2 0.690 APOA4 CD163 PGLYRP2 SEPP1 0.689 APOA4 PGLYRP2 S100A8 VASN 0.689 APOA1 CLU IGFBP6 TAGLN2 0.689 APOA1 CD163 CPN2 SEPP1 0.688 APOA1 CD14 SEPP1 TLN1 0.688 APOA1 CD14 CD163 S100A8 0.688 APOA4 CLU IGFBP6 TAGLN2 0.688 IGFBP6 MST1 TAGLN2 TLN1 0.688 APOA1 APOA4 S100A8 TLN1 0.688 APOA1 APOA4 S100A9 TAGLN2 0.688 CLU S100A9 TAGLN2 TLN1 0.688 APOA4 CD163 CLU PGLYRP2 0.688 IGFBP6 MST1 PFN1 TLN1 0.687 CLU CPN2 VASN VCAM1 0.687 APOA4 S100A9 VASN VCAM1 0.687 APOA1 CPN2 S100A9 TLN1 0.687 APOA1 PGLYRP2 S100A8 VASN 0.687 APOA1 MST1 SEPP1 VCAM1 0.687 APOA1 MST1 TAGLN2 VCAM1 0.687 APOA1 MST1 SEPP1 TLN1 0.686 CD163 IGFBP6 MST1 S100A9 0.686 CD14 CD163 TAGLN2 VCAM1 0.686 APOA4 CLU PGLYRP2 VASN 0.686 CD14 MST1 SEPP1 TLN1 0.685 CPN2 SEPP1 VASN VCAM1 0.685 CD163 IGFBP6 S100A8 VCAM1 0.685 IGFBP6 SEPP1 TAGLN2 TLN1 0.685 APOA1 APOA4 S100A9 TLN1 0.685 IGFBP6 PFN1 SEPP1 TLN1 0.685 APOA4 IGFBP6 TAGLN2 VASN 0.684 APOA1 MST1 TLN1 VASN 0.684 APOA1 S100A8 TAGLN2 TLN1 0.684 CLU PGLYRP2 S100A9 VCAM1 0.684 CD14 S100A8 SEPP1 VASN 0.683 IGFBP6 S100A8 SEPP1 VASN 0.683 CD163 IGFBP6 S100A9 TLN1 0.683 APOA4 CPN2 IGFBP6 SEPP1 0.683 APOA4 CD14 S100A8 VASN 0.683 APOA1 IGFBP6 S100A9 VASN 0.683 CLU SEPP1 VASN VCAM1 0.682 CLU IGFBP6 SEPP1 TAGLN2 0.682 APOA4 CLU IGFBP6 S100A9 0.682 APOA1 PFN1 TAGLN2 VCAM1 0.682 CD163 S100A9 SEPP1 VASN 0.682 CD14 MST1 TLN1 VASN 0.682 APOA1 CLU VASN VCAM1 0.682 CD14 IGFBP6 S100A8 SEPP1 0.682 MST1 S100A9 SEPP1 TLN1 0.682 CLU IGFBP6 S100A9 VASN 0.682 APOA1 TAGLN2 TLN1 VCAM1 0.682 APOA4 CLU PGLYRP2 VCAM1 0.682 CD14 S100A9 SEPP1 VASN 0.682 APOA1 IGFBP6 TLN1 VCAM1 0.682 CLU CPN2 TLN1 VCAM1 0.682 APOA4 IGFBP6 PFN1 VASN 0.681 CD163 CPN2 PFN1 TAGLN2 0.681 APOA4 MST1 SEPP1 VASN 0.681 IGFBP6 SEPP1 TAGLN2 VASN 0.681 APOA4 PGLYRP2 S100A8 SEPP1 0.681 APOA4 SEPP1 TLN1 VASN 0.681 CD163 CLU PGLYRP2 S100A9 0.681 APOA1 APOA4 CLU TLN1 0.681 CD163 S100A8 SEPP1 VASN 0.681 APOA1 APOA4 SEPP1 TLN1 0.681 CD163 CPN2 S100A8 SEPP1 0.681 APOA1 IGFBP6 SEPP1 TAGLN2 0.681 APOA1 CD14 S100A8 VASN 0.680 APOA1 APOA4 PGLYRP2 VCAM1 0.680 APOA1 CLU PGLYRP2 VASN 0.680 APOA1 CLU PGLYRP2 S100A8 0.680 IGFBP6 MST1 S100A9 TLN1 0.680 APOA1 APOA4 MST1 TAGLN2 0.680 APOA1 CD163 CPN2 S100A8 0.679 APOA1 PGLYRP2 S100A8 SEPP1 0.679 APOA1 CLU PGLYRP2 S100A9 0.679 APOA1 IGFBP6 SEPP1 VCAM1 0.679 APOA1 IGFBP6 MST1 SEPP1 0.679 APOA4 IGFBP6 SEPP1 VCAM1 0.678 CLU IGFBP6 PFN1 SEPP1 0.678 CD163 CPN2 S100A9 SEPP1 0.678 APOA1 CD14 CD163 MST1 0.678 APOA1 CD14 CD163 S100A9 0.677 APOA4 PGLYRP2 SEPP1 VCAM1 0.677 CD14 CD163 MST1 SEPP1 0.677 APOA1 CD14 TLN1 VCAM1 0.677 APOA4 CD14 SEPP1 VASN 0.676 APOA1 APOA4 CD14 IGFBP6 0.676 APOA4 PFN1 TLN1 VASN 0.676 CD14 CD163 PFN1 VCAM1 0.676 APOA1 PFN1 TLN1 VCAM1 0.675 IGFBP6 S100A9 SEPP1 TLN1 0.675 CD14 IGFBP6 MST1 SEPP1 0.675 PFN1 SEPP1 TAGLN2 TLN1 0.675 CLU PGLYRP2 S100A8 VCAM1 0.675 APOA1 CD14 SEPP1 VASN 0.675 CD163 PGLYRP2 SEPP1 VCAM1 0.674 APOA4 CLU PGLYRP2 S100A9 0.674 IGFBP6 PFN1 SEPP1 VASN 0.674 CPN2 PFN1 TAGLN2 TLN1 0.674 CLU S100A9 SEPP1 TLN1 0.674 CD14 IGFBP6 SEPP1 VCAM1 0.674 APOA4 IGFBP6 S100A8 VASN 0.673 CD14 S100A8 SEPP1 TLN1 0.672 APOA4 TAGLN2 TLN1 VASN 0.672 APOA4 IGFBP6 PFN1 TAGLN2 0.672 APOA4 S100A8 VASN VCAM1 0.672 IGFBP6 S100A9 SEPP1 VASN 0.672 MST1 S100A8 SEPP1 VCAM1 0.672 APOA1 APOA4 CD163 MST1 0.672 S100A8 SEPP1 TLN1 VCAM1 0.672 APOA1 CD14 S100A9 TLN1 0.672 CD14 IGFBP6 TLN1 VCAM1 0.672 CD14 MST1 PFN1 TAGLN2 0.671 CD14 IGFBP6 S100A8 VCAM1 0.671 CD163 IGFBP6 S100A9 SEPP1 0.671 CD163 CLU PGLYRP2 S100A8 0.670 APOA1 MST1 PFN1 VCAM1 0.670 APOA4 CLU PGLYRP2 S100A8 0.670 CD14 SEPP1 TLN1 VCAM1 0.670 APOA4 CD163 CPN2 SEPP1 0.670 APOA1 MST1 PFN1 TAGLN2 0.669 IGFBP6 SEPP1 TLN1 VASN 0.669 APOA1 IGFBP6 S100A9 SEPP1 0.669 CD14 PFN1 TAGLN2 VCAM1 0.669 APOA4 CD14 CD163 S100A8 0.669 APOA1 IGFBP6 TLN1 VASN 0.668 APOA1 IGFBP6 PFN1 SEPP1 0.668 APOA4 CLU TLN1 VASN 0.668 CD163 CLU PGLYRP2 VCAM1 0.667 APOA1 IGFBP6 S100A8 SEPP1 0.667 CD163 MST1 SEPP1 VCAM1 0.667 IGFBP6 MST1 S100A9 SEPP1 0.667 CLU S100A8 TLN1 VASN 0.667 APOA1 CLU S100A8 TLN1 0.667 APOA1 APOA4 CLU PGLYRP2 0.666 APOA4 IGFBP6 S100A9 VASN 0.666 APOA1 CLU SEPP1 TLN1 0.666 APOA1 MST1 S100A8 VCAM1 0.666 APOA1 APOA4 PGLYRP2 S100A9 0.666 CD14 CD163 IGFBP6 S100A8 0.666 APOA4 IGFBP6 S100A9 SEPP1 0.665 APOA1 CD14 MST1 S100A8 0.665 APOA1 S100A9 TAGLN2 TLN1 0.665 APOA4 IGFBP6 S100A8 SEPP1 0.665 PGLYRP2 S100A8 SEPP1 VCAM1 0.665 CPN2 S100A8 SEPP1 VASN 0.664 APOA4 IGFBP6 SEPP1 TAGLN2 0.664 APOA1 CD14 CD163 SEPP1 0.664 APOA1 CD14 IGFBP6 VCAM1 0.664 MST1 PFN1 TLN1 VASN 0.664 CPN2 SEPP1 TLN1 VASN 0.664 APOA1 APOA4 IGFBP6 TAGLN2 0.664 S100A9 SEPP1 VASN VCAM1 0.664 IGFBP6 S100A9 SEPP1 VCAM1 0.663 APOA1 SEPP1 TLN1 VCAM1 0.663 APOA1 CD163 CPN2 S100A9 0.663 CD163 CPN2 S100A8 VCAM1 0.663 APOA1 APOA4 CLU MST1 0.663 CD14 TAGLN2 TLN1 VCAM1 0.663 CD14 MST1 TAGLN2 VCAM1 0.661 APOA1 APOA4 CD163 CPN2 0.661 APOA1 CD163 IGFBP6 VCAM1 0.661 CD14 CD163 TAGLN2 TLN1 0.660 CPN2 PFN1 SEPP1 TAGLN2 0.660 APOA1 IGFBP6 PFN1 TLN1 0.660 APOA4 CD14 S100A9 VCAM1 0.660 APOA4 CLU PFN1 TLN1 0.659 CD14 IGFBP6 S100A9 TLN1 0.659 APOA1 APOA4 IGFBP6 PFN1 0.659 CLU CPN2 SEPP1 TLN1 0.659 PFN1 SEPP1 TLN1 VASN 0.658 CD14 IGFBP6 MST1 TLN1 0.658 CLU CPN2 PFN1 SEPP1 0.658 APOA4 CLU TAGLN2 TLN1 0.658 APOA4 PFN1 SEPP1 TAGLN2 0.658 APOA4 MST1 S100A8 SEPP1 0.657 APOA1 APOA4 CD163 IGFBP6 0.657 CD163 IGFBP6 SEPP1 VCAM1 0.657 APOA4 CD163 CPN2 S100A8 0.657 CD163 CLU PFN1 VCAM1 0.657 CD14 CD163 IGFBP6 TLN1 0.657 APOA1 APOA4 PGLYRP2 S100A8 0.657 CD14 PFN1 TLN1 VCAM1 0.656 PGLYRP2 S100A9 SEPP1 VCAM1 0.656 APOA1 S100A8 SEPP1 TLN1 0.656 CD14 S100A9 SEPP1 TLN1 0.656 APOA1 APOA4 CD14 VASN 0.656 APOA4 CD14 CD163 SEPP1 0.656 APOA4 MST1 S100A9 SEPP1 0.655 CLU PGLYRP2 S100A8 SEPP1 0.655 APOA4 CPN2 PFN1 SEPP1 0.655 APOA4 CD163 CPN2 S100A9 0.655 APOA1 CD14 SEPP1 VCAM1 0.655 CLU PFN1 SEPP1 TLN1 0.654 APOA4 CD163 PGLYRP2 VCAM1 0.654 IGFBP6 MST1 TLN1 VCAM1 0.654 CD163 IGFBP6 S100A9 VCAM1 0.654 S100A9 SEPP1 TLN1 VCAM1 0.653 APOA1 S100A8 TLN1 VCAM1 0.653 APOA1 IGFBP6 TAGLN2 TLN1 0.653 APOA1 APOA4 IGFBP6 S100A9 0.652 CD14 MST1 SEPP1 VCAM1 0.652 APOA1 CPN2 TLN1 VASN 0.652 CD163 CPN2 SEPP1 VCAM1 0.652 CLU CPN2 SEPP1 TAGLN2 0.651 APOA1 APOA4 IGFBP6 S100A8 0.651 APOA1 APOA4 MST1 VASN 0.651 APOA1 APOA4 TAGLN2 TLN1 0.651 APOA1 APOA4 MST1 S100A8 0.651 SEPP1 TAGLN2 TLN1 VASN 0.651 APOA4 IGFBP6 PFN1 SEPP1 0.650 APOA1 CPN2 S100A9 VCAM1 0.650 CD163 CLU TAGLN2 VCAM1 0.650 CD163 IGFBP6 MST1 TLN1 0.649 APOA1 MST1 S100A9 SEPP1 0.649 CD163 CPN2 S100A9 VCAM1 0.649 APOA1 CPN2 S100A8 VCAM1 0.649 APOA4 CLU PGLYRP2 SEPP1 0.648 APOA1 CD14 MST1 S100A9 0.648 MST1 S100A9 SEPP1 VCAM1 0.647 APOA4 CLU PFN1 SEPP1 0.647 CD14 CD163 IGFBP6 MST1 0.647 APOA1 CLU PGLYRP2 SEPP1 0.647 APOA1 APOA4 MST1 SEPP1 0.647 CLU SEPP1 TAGLN2 TLN1 0.647 CLU PGLYRP2 S100A9 SEPP1 0.647 CD14 PFN1 TAGLN2 TLN1 0.646 APOA1 SEPP1 TLN1 VASN 0.646 APOA1 CD163 S100A9 SEPP1 0.646 CLU S100A9 TLN1 VASN 0.646 APOA4 CD163 MST1 S100A8 0.645 APOA1 APOA4 TLN1 VASN 0.645 APOA1 CLU CPN2 PFN1 0.645 APOA4 CPN2 S100A8 VCAM1 0.645 APOA1 APOA4 MST1 S100A9 0.645 APOA1 CD14 MST1 VASN 0.645 APOA1 CPN2 SEPP1 VCAM1 0.645 CPN2 S100A8 SEPP1 VCAM1 0.644 APOA1 CD163 CPN2 VCAM1 0.644 APOA4 CD14 MST1 SEPP1 0.643 APOA4 CPN2 SEPP1 VCAM1 0.643 APOA1 APOA4 CPN2 VCAM1 0.643 APOA1 CLU IGFBP6 VASN 0.642 CPN2 PFN1 TLN1 VASN 0.642 APOA4 CD163 MST1 S100A9 0.642 APOA4 CLU SEPP1 TAGLN2 0.642 CD14 MST1 PFN1 TLN1 0.641 APOA1 IGFBP6 SEPP1 TLN1 0.641 APOA1 S100A9 TLN1 VCAM1 0.641 APOA1 S100A8 TLN1 VASN 0.641 APOA1 PFN1 SEPP1 TLN1 0.641 CLU PFN1 SEPP1 TAGLN2 0.641 APOA1 PFN1 SEPP1 TAGLN2 0.640 APOA4 CPN2 SEPP1 TAGLN2 0.640 APOA4 CD163 S100A9 SEPP1 0.639 CD163 CLU CPN2 TAGLN2 0.639 APOA4 CPN2 PFN1 TAGLN2 0.639 APOA4 CD163 IGFBP6 VCAM1 0.638 CD14 IGFBP6 S100A9 VCAM1 0.638 CD163 CLU PFN1 TAGLN2 0.638 APOA1 CD14 S100A8 SEPP1 0.638 APOA4 CPN2 S100A9 VCAM1 0.638 APOA1 APOA4 CD163 S100A9 0.638 APOA1 CPN2 PFN1 TAGLN2 0.637 APOA1 APOA4 CD163 SEPP1 0.637 APOA1 APOA4 PFN1 TLN1 0.636 CPN2 S100A9 SEPP1 VCAM1 0.636 CD163 CLU CPN2 SEPP1 0.636 CLU IGFBP6 SEPP1 VASN 0.636 APOA1 CLU S100A9 TLN1 0.636 CD14 IGFBP6 S100A9 SEPP1 0.636 APOA4 CD163 MST1 VCAM1 0.635 CD163 CLU CPN2 PFN1 0.635 CD14 CD163 PFN1 TLN1 0.635 APOA1 PFN1 SEPP1 VASN 0.635 APOA1 CD163 S100A8 SEPP1 0.634 APOA1 S100A9 SEPP1 TLN1 0.634 CD14 CD163 IGFBP6 VCAM1 0.634 APOA4 CD163 S100A8 SEPP1 0.634 APOA1 MST1 TLN1 VCAM1 0.633 APOA1 CPN2 PFN1 SEPP1 0.633 APOA4 CLU IGFBP6 VASN 0.633 APOA4 CD14 CD163 MST1 0.632 APOA1 APOA4 PFN1 TAGLN2 0.632 APOA4 CD163 CPN2 VCAM1 0.632 APOA1 CD163 CLU SEPP1 0.631 APOA1 CLU CPN2 TLN1 0.631 APOA4 CD14 S100A8 VCAM1 0.631 CPN2 TAGLN2 TLN1 VASN 0.631 APOA1 CLU IGFBP6 SEPP1 0.630 CLU CPN2 S100A9 TLN1 0.630 APOA1 SEPP1 TAGLN2 VASN 0.630 APOA4 MST1 S100A8 VCAM1 0.630 APOA1 CLU CPN2 TAGLN2 0.629 CLU PFN1 TAGLN2 TLN1 0.629 APOA1 CD14 S100A8 VCAM1 0.628 APOA1 APOA4 CLU IGFBP6 0.628 APOA1 PFN1 TLN1 VASN 0.628 APOA4 PFN1 TAGLN2 VASN 0.627 APOA4 MST1 S100A9 VCAM1 0.627 APOA4 CLU PFN1 VASN 0.627 APOA1 APOA4 CD14 S100A9 0.626 CD163 CLU CPN2 S100A8 0.626 APOA1 S100A9 TLN1 VASN 0.625 CD14 IGFBP6 MST1 S100A9 0.625 CLU CPN2 TAGLN2 TLN1 0.625 APOA1 SEPP1 TAGLN2 TLN1 0.624 APOA4 CLU CPN2 PFN1 0.624 CD163 S100A8 TLN1 VCAM1 0.624 APOA4 CD14 SEPP1 VCAM1 0.624 APOA1 CD163 SEPP1 VCAM1 0.624 CD14 CD163 SEPP1 VCAM1 0.623 APOA1 IGFBP6 SEPP1 VASN 0.623 APOA1 CD14 MST1 SEPP1 0.623 APOA1 APOA4 CD163 S100A8 0.623 APOA4 CD163 CLU CPN2 0.623 CD14 CD163 IGFBP6 S100A9 0.623 APOA4 CLU CPN2 VCAM1 0.623 APOA4 CD163 CLU S100A8 0.623 APOA1 APOA4 IGFBP6 VCAM1 0.623 APOA4 CLU SEPP1 VCAM1 0.622 APOA1 MST1 S100A9 VCAM1 0.621 APOA4 CD14 S100A9 SEPP1 0.621 CD14 MST1 TAGLN2 TLN1 0.621 APOA4 CLU PFN1 TAGLN2 0.620 CLU SEPP1 TLN1 VASN 0.620 CLU TAGLN2 TLN1 VASN 0.620 APOA1 CLU PFN1 SEPP1 0.619 APOA4 CPN2 TAGLN2 VASN 0.619 APOA4 PFN1 SEPP1 VASN 0.619 APOA1 PFN1 TAGLN2 TLN1 0.619 CD14 CD163 S100A8 TLN1 0.618 CLU PFN1 SEPP1 VASN 0.618 CLU CPN2 PFN1 TLN1 0.618 APOA4 CPN2 PFN1 VASN 0.618 APOA1 CLU SEPP1 VCAM1 0.618 APOA4 CD163 CLU S100A9 0.618 APOA1 APOA4 PFN1 SEPP1 0.617 CPN2 SEPP1 TAGLN2 VASN 0.617 APOA4 CLU CPN2 TAGLN2 0.616 APOA4 CLU TAGLN2 VASN 0.616 CD14 S100A8 TLN1 VCAM1 0.616 APOA4 CLU IGFBP6 SEPP1 0.616 APOA1 APOA4 PFN1 VASN 0.615 PFN1 SEPP1 TAGLN2 VASN 0.615 CPN2 S100A9 SEPP1 VASN 0.615 APOA1 S100A8 SEPP1 VCAM1 0.615 APOA4 CD163 S100A9 VCAM1 0.615 APOA4 CD163 CLU SEPP1 0.615 CPN2 PFN1 SEPP1 VASN 0.614 CPN2 PFN1 TAGLN2 VASN 0.614 APOA4 CLU S100A8 VCAM1 0.614 CLU CPN2 TLN1 VASN 0.614 APOA1 APOA4 CD14 CD163 0.614 APOA1 CD14 S100A9 VCAM1 0.613 APOA4 CD14 S100A8 SEPP1 0.613 APOA1 CPN2 SEPP1 TAGLN2 0.613 CLU CPN2 PFN1 TAGLN2 0.613 CLU CPN2 PFN1 VASN 0.613 APOA1 CD14 S100A9 SEPP1 0.611 APOA1 APOA4 CPN2 PFN1 0.611 CD163 CLU S100A9 SEPP1 0.610 APOA1 APOA4 IGFBP6 VASN 0.610 APOA1 PFN1 TAGLN2 VASN 0.610 CLU SEPP1 TAGLN2 VASN 0.609 APOA1 CD163 CLU S100A8 0.609 CD14 S100A9 SEPP1 VCAM1 0.609 APOA1 APOA4 CD14 S100A8 0.608 CLU CPN2 SEPP1 VCAM1 0.608 APOA4 CD14 MST1 VCAM1 0.608 CLU CPN2 S100A8 VCAM1 0.608 APOA1 CD14 CD163 VCAM1 0.608 CD163 CLU S100A8 SEPP1 0.608 APOA4 IGFBP6 SEPP1 VASN 0.608 APOA1 CPN2 PFN1 VASN 0.608 CD14 S100A8 SEPP1 VCAM1 0.607 MST1 S100A8 TLN1 VCAM1 0.607 APOA4 CD14 MST1 S100A9 0.607 APOA4 SEPP1 TAGLN2 VASN 0.606 APOA1 CLU CPN2 VCAM1 0.606 CD163 MST1 PFN1 TAGLN2 0.606 APOA1 TAGLN2 TLN1 VASN 0.606 APOA1 APOA4 CD163 CLU 0.605 CLU S100A8 SEPP1 VCAM1 0.605 APOA1 CD163 S100A8 VCAM1 0.604 APOA4 CD14 MST1 S100A8 0.604 APOA1 CLU PFN1 TAGLN2 0.603 APOA1 CLU S100A8 VCAM1 0.603 APOA1 CLU PFN1 TLN1 0.603 APOA1 CLU SEPP1 TAGLN2 0.603 APOA4 CLU S100A9 VCAM1 0.603 APOA1 CLU PFN1 VASN 0.602 APOA4 S100A9 SEPP1 VCAM1 0.602 APOA1 APOA4 SEPP1 TAGLN2 0.601 APOA1 CD163 CLU VCAM1 0.601 CLU PFN1 TLN1 VASN 0.601 APOA1 CPN2 TAGLN2 VASN 0.600 APOA4 CD14 CD163 VCAM1 0.600 APOA1 S100A9 SEPP1 VCAM1 0.600 CLU CPN2 TAGLN2 VASN 0.600 APOA1 CD163 S100A9 VCAM1 0.600 APOA1 APOA4 MST1 VCAM1 0.600 APOA1 APOA4 SEPP1 VCAM1 0.600 CD163 CLU CPN2 S100A9 0.600 APOA1 CD163 CLU S100A9 0.599 APOA4 CPN2 S100A8 SEPP1 0.599 APOA1 CD14 MST1 VCAM1 0.599 APOA1 APOA4 S100A9 VCAM1 0.599 APOA4 CD163 S100A8 VCAM1 0.599 APOA1 APOA4 CD14 MST1 0.598 PFN1 TAGLN2 TLN1 VASN 0.598 CD14 CD163 TLN1 VCAM1 0.598 APOA4 S100A8 SEPP1 VCAM1 0.598 APOA1 CPN2 S100A8 VASN 0.598 CD163 CLU SEPP1 VCAM1 0.597 CD163 MST1 S100A8 TLN1 0.597 APOA4 CPN2 S100A8 VASN 0.597 APOA1 CLU TAGLN2 TLN1 0.595 APOA1 APOA4 CLU PFN1 0.594 CD163 MST1 TAGLN2 VCAM1 0.594 APOA1 APOA4 IGFBP6 SEPP1 0.593 APOA1 CPN2 S100A9 VASN 0.593 CD14 CD163 S100A9 TLN1 0.593 APOA1 CLU TLN1 VASN 0.593 APOA1 APOA4 TAGLN2 VASN 0.592 APOA1 APOA4 CD14 SEPP1 0.591 APOA1 APOA4 CLU VCAM1 0.591 APOA1 APOA4 CPN2 S100A8 0.590 CD163 S100A9 TLN1 VCAM1 0.589 APOA1 APOA4 S100A8 VCAM1 0.589 APOA4 CPN2 S100A9 VASN 0.588 APOA1 APOA4 CPN2 TAGLN2 0.588 CD14 MST1 S100A8 SEPP1 0.588 CD14 MST1 S100A9 SEPP1 0.588 CD163 CLU CPN2 VCAM1 0.587 APOA1 APOA4 CLU TAGLN2 0.587 CD14 S100A9 TLN1 VCAM1 0.587 CLU S100A9 SEPP1 VCAM1 0.586 CLU CPN2 S100A9 VCAM1 0.586 CD163 PFN1 TAGLN2 TLN1 0.585 MST1 PFN1 TAGLN2 VCAM1 0.585 APOA1 CPN2 SEPP1 VASN 0.585 CD163 CLU S100A8 VCAM1 0.584 APOA4 CD163 SEPP1 VCAM1 0.584 CD163 TAGLN2 TLN1 VCAM1 0.584 APOA4 CPN2 S100A9 SEPP1 0.584 CLU CPN2 S100A8 SEPP1 0.583 APOA4 CD163 CLU VCAM1 0.582 CLU PFN1 TAGLN2 VASN 0.581 CD163 PFN1 TAGLN2 VCAM1 0.581 APOA1 CPN2 S100A8 SEPP1 0.581 APOA4 CPN2 SEPP1 VASN 0.580 APOA1 CLU S100A9 VCAM1 0.580 APOA1 APOA4 CPN2 S100A9 0.579 APOA1 APOA4 CD14 VCAM1 0.578 APOA1 CLU TAGLN2 VASN 0.578 CD14 MST1 S100A8 TLN1 0.577 CD163 MST1 PFN1 TLN1 0.576 CD163 MST1 PFN1 VCAM1 0.576 CLU CPN2 S100A9 SEPP1 0.576 APOA1 APOA4 CD163 VCAM1 0.575 APOA1 S100A8 SEPP1 VASN 0.574 CD163 MST1 TAGLN2 TLN1 0.574 APOA1 CPN2 S100A9 SEPP1 0.571 CD163 PFN1 TLN1 VCAM1 0.570 CLU S100A8 SEPP1 VASN 0.570 APOA4 S100A8 SEPP1 VASN 0.570 CLU CPN2 SEPP1 VASN 0.569 CD163 CLU S100A9 VCAM1 0.569 APOA4 S100A9 SEPP1 VASN 0.569 MST1 PFN1 TAGLN2 TLN1 0.568 MST1 S100A9 TLN1 VCAM1 0.567 CLU S100A9 SEPP1 VASN 0.566 MST1 TAGLN2 TLN1 VCAM1 0.566 APOA1 S100A9 SEPP1 VASN 0.566 CD163 MST1 S100A9 TLN1 0.564 APOA1 CLU CPN2 VASN 0.564 CD14 CD163 MST1 TLN1 0.564 PFN1 TAGLN2 TLN1 VCAM1 0.563 CD163 S100A8 SEPP1 VCAM1 0.562 APOA1 CLU CPN2 S100A8 0.562 CD163 S100A9 SEPP1 VCAM1 0.561 APOA1 CLU SEPP1 VASN 0.559 APOA1 APOA4 CPN2 VASN 0.558 APOA1 APOA4 S100A8 SEPP1 0.556 CLU CPN2 S100A8 VASN 0.556 CD14 MST1 TLN1 VCAM1 0.552 APOA4 CLU CPN2 S100A8 0.550 APOA1 CLU CPN2 S100A9 0.550 APOA1 CLU CPN2 SEPP1 0.550 APOA4 CLU CPN2 SEPP1 0.549 APOA1 APOA4 S100A9 SEPP1 0.547 APOA1 APOA4 S100A8 VASN 0.547 APOA1 APOA4 SEPP1 VASN 0.546 MST1 PFN1 TLN1 VCAM1 0.545 APOA4 CLU SEPP1 VASN 0.544 APOA1 APOA4 CPN2 SEPP1 0.544 CD14 MST1 S100A8 VCAM1 0.543 APOA4 CLU CPN2 S100A9 0.543 APOA1 APOA4 S100A9 VASN 0.543 APOA1 APOA4 CLU CPN2 0.543 APOA1 CLU S100A8 SEPP1 0.542 APOA4 CLU S100A8 SEPP1 0.542 CLU CPN2 S100A9 VASN 0.542 CD14 MST1 S100A9 TLN1 0.540 APOA4 CLU CPN2 VASN 0.540 APOA4 CLU S100A9 SEPP1 0.537 APOA4 CLU S100A8 VASN 0.536 CD163 MST1 TLN1 VCAM1 0.530 APOA4 CLU S100A9 VASN 0.529 CD14 MST1 S100A9 VCAM1 0.529 APOA1 CLU S100A9 SEPP1 0.529 APOA1 CLU S100A8 VASN 0.523 CD14 CD163 S100A8 VCAM1 0.519 CD14 CD163 MST1 S100A8 0.514 APOA1 CLU S100A9 VASN 0.514 CD14 CD163 S100A9 VCAM1 0.513 APOA1 APOA4 CLU S100A8 0.511 APOA1 APOA4 CLU SEPP1 0.509 APOA1 APOA4 CLU S100A9 0.508 CD163 MST1 S100A8 VCAM1 0.507 CD14 CD163 MST1 VCAM1 0.504 APOA1 APOA4 CLU VASN 0.502 CD14 CD163 MST1 S100A9 0.490 CD163 MST1 S100A9 VCAM1 0.471

EQUIVALENTS

In describing exemplary embodiments, specific terminology is used for the sake of clarity. For purposes of description, each specific term is intended to at least include all technical and functional equivalents that operate in a similar manner to accomplish a similar purpose. Additionally, in some instances where a particular exemplary embodiment includes a plurality of system elements or method steps, those elements or steps may be replaced with a single element or step. Likewise, a single element or step may be replaced with a plurality of elements or steps that serve the same purpose. Further, where parameters for various properties are specified herein for exemplary embodiments, those parameters may be adjusted up or down by 1/20th, 1/10th, ⅕th, ⅓rd, ½, etc., or by rounded-off approximations thereof, unless otherwise specified. Moreover, while exemplary embodiments have been shown and described with references to particular embodiments thereof, those of ordinary skill in the art will understand that various substitutions and alterations in form and details may be made therein without departing from the scope of the invention. Further still, other aspects, functions and advantages are also within the scope of the invention.

Exemplary flowcharts are provided herein for illustrative purposes and are non-limiting examples of methods. One of ordinary skill in the art will recognize that exemplary methods may include more or fewer steps than those illustrated in the exemplary flowcharts, and that the steps in the exemplary flowcharts may be performed in a different order than shown.

INCORPORATION BY REFERENCE

The contents of all references, including patents and patent applications, cited throughout this application are hereby incorporated herein by reference in their entirety. The appropriate components and methods of those references may be selected for the invention and embodiments thereof. Still further, the components and methods identified in the Background section are integral to this disclosure and can be used in conjunction with or substituted for components and methods described elsewhere in the disclosure within the scope of the invention.

Claims

1. A method for determining whether a subject has active tuberculosis (TB), the method comprising

determining the level of one or more markers listed in Table 1 in a sample(s) from the subject;
comparing the level of the one or more markers in the subject sample(s) with a level of the one or more markers in a control sample(s), wherein a difference in the level of the one or more markers in the subject sample(s) as compared to the level of the one or more markers in the control sample(s) indicates that the subject has active TB.

2. A method for monitoring the effectiveness of a treatment in a subject having active tuberculosis (TB), the method comprising

determining the level of one or more markers listed in Table 1 in a first sample(s) from the subject prior to the initiation of the treatment;
determining the level of one or more markers listed in Table 1 in a second sample(s) from the subject after at least a portion of the treatment has been administered;
comparing the level of the one or more markers in the first sample(s) with a level of the one or more markers in the second sample(s), wherein a difference in the level of the one or more markers in the first sample(s) as compared to the level of the one or more markers in the second sample(s) indicates that the treatment is effective.

3. The method of claim 1 or 2, wherein the level in the subject sample(s) is determined by mass spectrometry or immunoassay.

4. The method of claim 1 or 2, wherein the sample(s) from the subject is a fluid sample(s) or a tissue sample(s).

5. The method of claim 1 or 2, wherein the subject is HIV negative (HIV−) or HIV positive (HIV+).

6. The method of claim 1 or 2, wherein the subject resides in North America or Europe.

7. The method of claim 1 or 2, wherein the one or more markers is selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, PGLYRP2, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS.

8. The method of claim 7, further comprising determining the level of one or more markers selected from the group consisting of CPB2, GP1BA, GPS, GPX3, PROCR, VWF, ATRN, CD14, DBH, SELL, VCAM1, S100A8, S100A9, CD163, CPN1, FCN3, HIST2H2BE, KNG1, MASP1, MASP2, PROS1, YWHAZ, CAL ORM1, PDLIM1, PGLYRP2, LCAT, LPA, PCSK9, PON1, PTGDS, APOA1, APOA4, APOC1, APOC3, APOE, ANPEP, BCHE, BTD, CDHS, CLEC3B, CLU, CNTN1, ECM1, GPLD1, HABP2, HGFAC, HYOU1, IGFALS, IGFBP3, IGFBP6, LCP1, LGALS3BP, LUM, MINPP1, MST1, NCAM1, NID1, PEPD, PFN1, PRG4, QSOX1, SEPP1, SHBG, SPARC, TGFBI, THBS1, TLN1, TNXB, VASN, VTN, YWHAE, CA2, CKM, CNDP1, COMP, IGF2, LRG1, PI16, PRDX2, PTPRG, SPP2, TAGLN2, ZYX, MTB81, MTB51, CACNA2D1, CPN2, and MAN1A1.

9. A kit for determining whether a subject has active tuberculosis (TB), the kit comprising reagents for determining the level of one or more markers listed in Table 1 in a subject sample(s) and instructions for use of the kit to determine whether the subject has active TB.

10. A kit of monitoring the effectiveness of a treatment in a subject having active TB the kit comprising reagents for determining the level of one or more markers listed in Table 1 in a subject sample(s) and instructions for use of the kit to monitor the effectiveness of the treatment.

11. The kit of any of claim 9 or 10, further comprising reagents for determining the level of one or more additional markers selected from the group consisting of APOE, SELL, TNXB, COMP, LUM, PGLYRP2, HABP2, LRG1, QSOX1, S100A8, APOC3, LCP1, VASN, PFN1, IGFBP6, LRG1, PGLYRP2, APOA4, BCHE, PI16, SEPP1, APOA1, IGFALS, CD14, TAGLN2, CPN2, APOC1, PEPD, GP1BA and PTGDS in a sample(s) from the subject.

12.-19. (canceled)

Patent History
Publication number: 20180172699
Type: Application
Filed: Nov 16, 2017
Publication Date: Jun 21, 2018
Inventors: Eustache Paramithiotis (Boucherville), Pascal Croteau (Laval), Jacqueline Michele Achkar (Brooklyn, NY)
Application Number: 15/814,554
Classifications
International Classification: G01N 33/68 (20060101); G01N 33/569 (20060101);