ACVR2A-SPECIFIC ANTIBODY AND METHOD OF USE THEREOF

Abstract

The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B, as well as methods for using the same. The antibodies may be used for the treatment of a number of conditions associated with muscle atrophy, as well as other conditions.

Description

CROSS-REFERENCING

This application claims the benefit of U.S. provisional application Ser. No. 62/477,911, filed on Mar. 28, 2017, which application is incorporated herein in its entirety.

BACKGROUND

The activin receptor, type II A (ACVR2A) is a high affinity receptor for the activin proteins as well as other members of the TGF-beta superfamily. ACVR2A is generally thought to transduce signals that lead to the phosphorylation of one or more SMAD transcription factors, particularly SMADs 1, 2, 3 and 5. ACVR2A has been implicated in the regulation of a wide range of biological processes, including bone formation, muscle formation, red blood cell formation, tumor growth, immune function and the production of reproductive hormones.

There is a need for reagents, e.g., antibodies, that specifically bind to ACVR2A and inhibit ACVR2A signaling.

SUMMARY OF THE INVENTION

The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B. The antibodies are useful in various treatment, diagnostic, and monitoring applications. In some embodiments, an antibody may comprise: (a) a variable domain comprising: i. heavy chain CDR1, CDR2 and CDR3 regions that are identical the heavy chain CDR1, CDR2 and CDR3 regions of an antibody selected from any of Tables 2A-2F; and ii. light chain CDR1, CDR2 and CDR3 regions that are identical the light chain CDR1, CDR2 and CDR3 regions of the antibody selected from any of Tables 2A-2F; or (b) a variant of said variable domain of (a) that is otherwise identical to said antibody variable domain except for up to 15 amino acid substitutions in said CDR regions.

In some embodiments, an antibody may comprise: (a) a heavy chain variable domain comprising a heavy chain framework, a CDR1 region, a CDR2 region, and a CDR3 region of sequence ARSATWHDTXLD (SEQ ID NO:6538) or a variant of ARSATWHDTXLD (SEQ ID NO:6538) that comprises up to three amino acid substitutions, and (b) a light chain variable domain comprising a light chain framework, a CDR1 region, a CDR2 region, and a CDR3 region.

Definitions

The terms “antibodies” and “immunoglobulin” include antibodies or immunoglobulins of any isotype, fragments of antibodies which retain specific binding to antigen, including, but not limited to, Fab, Fv, scFv, and Fd fragments, chimeric antibodies, humanized antibodies, single-chain antibodies, and fusion proteins comprising an antigen-binding portion of an antibody and a non-antibody protein. The antibodies may be detectably labeled, e.g., with a radioisotope, an enzyme which generates a detectable product, a fluorescent protein, and the like. The antibodies may be further conjugated to other moieties, such as members of specific binding pairs, e.g., biotin (member of biotin-avidin specific binding pair), and the like. The antibodies may also be bound to a solid support, including, but not limited to, polystyrene plates or beads, and the like. Also encompassed by the term are Fab′, Fv, F(ab′)₂, and or other antibody fragments that retain specific binding to antigen, and monoclonal antibodies. An antibody may be monovalent or bivalent.

“Antibody fragments” comprise a portion of an intact antibody, for example, the antigen binding or variable region of the intact antibody. Examples of antibody fragments include Fab, Fab′, F(ab′)₂, and Fv fragments; diabodies; linear antibodies (Zapata et al., Protein Eng. 8(10): 1057-1062 (1995)); single-chain antibody molecules; and multispecific antibodies formed from antibody fragments. Papain digestion of antibodies produces two identical antigen-binding fragments, called “Fab” fragments, each with a single antigen-binding site, and a residual “Fc” fragment, a designation reflecting the ability to crystallize readily. Pepsin treatment yields an F(ab′)₂ fragment that has two antigen combining sites and is still capable of cross-linking antigen.

“Fv” is the minimum antibody fragment which contains a complete antigen-recognition and -binding site. This region consists of a dimer of one heavy- and one light-chain variable domain in tight, non-covalent association. It is in this configuration that the three CDRS of each variable domain interact to define an antigen-binding site on the surface of the V_H-V_L dimer. Collectively, the six CDRs confer antigen-binding specificity to the antibody. However, even a single variable domain (or half of an Fv comprising only three CDRs specific for an antigen) has the ability to recognize and bind antigen, although at a lower affinity than the entire binding site.

The “Fab” fragment also contains the constant domain of the light chain and the first constant domain (CH₁) of the heavy chain. Fab fragments differ from Fab′ fragments by the addition of a few residues at the carboxyl terminus of the heavy chain CH₁ domain including one or more cysteines from the antibody hinge region. Fab′-SH is the designation herein for Fab′ in which the cysteine residue(s) of the constant domains bear a free thiol group. F(ab′)₂ antibody fragments originally were produced as pairs of Fab′ fragments which have hinge cysteines between them. Other chemical couplings of antibody fragments are also known.

The “light chains” of antibodies (immunoglobulins) from any vertebrate species can be assigned to one of two clearly distinct types, called kappa and lambda, based on the amino acid sequences of their constant domains. Depending on the amino acid sequence of the constant domain of their heavy chains, immunoglobulins can be assigned to different classes. There are five major classes of immunoglobulins: IgA, IgD, IgE, IgG, and IgM, and several of these may be further divided into subclasses (isotypes), e.g., IgG1, IgG2, IgG3, IgG4, IgA, and IgA2.

“Single-chain Fv” or “sFv” antibody fragments comprise the V_H and V_L domains of antibody, wherein these domains are present in a single polypeptide chain. In some embodiments, the Fv polypeptide further comprises a polypeptide linker between the V_H and V_L domains, which enables the sFv to form the desired structure for antigen binding. For a review of sFv, see Pluckthun in The Pharmacology of Monoclonal Antibodies, vol. 113, Rosenburg and Moore eds., Springer-Verlag, New York, pp. 269-315 (1994).

The term “diabodies” refers to small antibody fragments with two antigen-binding sites, which fragments comprise a heavy-chain variable domain (V_H) connected to a light-chain variable domain (V_L) in the same polypeptide chain (V_H—V_L). By using a linker that is too short to allow pairing between the two domains on the same chain, the domains are forced to pair with the complementary domains of another chain and create two antigen-binding sites. Diabodies are described more fully in, for example, EP 404,097; WO 93/11161; and Hollinger et al., Proc. Natl. Acad. Sci. USA, 90:6444-6448 (1993).

As used herein, the term “affinity” refers to the equilibrium constant for the reversible binding of two agents and is expressed as a dissociation constant (Kd). Affinity can be at least 1-fold greater, at least 2-fold greater, at least 3-fold greater, at least 4-fold greater, at least 5-fold greater, at least 6-fold greater, at least 7-fold greater, at least 8-fold greater, at least 9-fold greater, at least 10-fold greater, at least 20-fold greater, at least 30-fold greater, at least 40-fold greater, at least 50-fold greater, at least 60-fold greater, at least 70-fold greater, at least 80-fold greater, at least 90-fold greater, at least 100-fold greater, or at least 1000-fold greater, or more, than the affinity of an antibody for unrelated amino acid sequences. Affinity of an antibody to a target protein can be, for example, from about 100 nanomolar (nM) to about 0.1 nM, from about 100 nM to about 1 picomolar (pM), or from about 100 nM to about 1 femtomolar (fM) or more. As used herein, the term “avidity” refers to the resistance of a complex of two or more agents to dissociation after dilution. The terms “immunoreactive” and “preferentially binds” are used interchangeably herein with respect to antibodies and/or antigen-binding fragments.

The term “binding” refers to a direct association between two molecules, due to, for example, covalent, electrostatic, hydrophobic, and ionic and/or hydrogen-bond interactions, including interactions such as salt bridges and water bridges. An ACVR2A-specific antibody antibodies binds specifically to an epitope within a ACVR2A polypeptide. Non-specific binding would refer to binding with an affinity of less than about 10⁻⁷ M, e.g., binding with an affinity of 10⁻⁶ M, 10⁻⁵ M, 10⁻⁴ M, etc.

As used herein, the term “CDR” or “complementarity determining region” is intended to mean the non-contiguous antigen combining sites found within the variable region of both heavy and light chain polypeptides. CDRs have been described by Kabat et al., J. Biol. Chem. 252:6609-6616 (1977); Kabat et al., U.S. Dept. of Health and Human Services, “Sequences of proteins of immunological interest” (1991); by Chothia et al., J. Mol. Biol. 196:901-917 (1987); and MacCallum et al., J. Mol. Biol. 262:732-745 (1996), where the definitions include overlapping or subsets of amino acid residues when compared against each other. Nevertheless, application of either definition to refer to a CDR of an antibody or grafted antibodies or variants thereof is intended to be within the scope of the term as defined and used herein. The amino acid residues which encompass the CDRs as defined by each of the above cited references are set forth below in Table 1 as a comparison.

TABLE 1
CDR Definitions
		Kabat1	Chothia2	MacCallum3
	VH CDR1	31-35	26-32	30-35
	VH CDR2	50-65	53-55	47-58
	VH CDR3	95-102	96-101	93-101
	VL CDR1	24-34	26-32	30-36
	VL CDR2	50-56	50-52	46-55
	VL CDR3	89-97	91-96	89-96
	1Residue numbering follows the nomenclature of Kabat et al., supra
	2Residue numbering follows the nomenclature of Chothia et al., supra
	3Residue numbering follows the nomenclature of MacCallum et al., supra

As used herein, the term “framework” when used in reference to an antibody variable region is intended to mean all amino acid residues outside the CDR regions within the variable region of an antibody. A variable region framework is generally a discontinuous amino acid sequence between about 100-120 amino acids in length but is intended to reference only those amino acids outside of the CDRs. As used herein, the term “framework region” is intended to mean each domain of the framework that is separated by the CDRs.

An “isolated” antibody is one that has been identified and separated and/or recovered from a component of its natural environment. Contaminant components of its natural environment are materials that would interfere with diagnostic or therapeutic uses for the antibody, and may include enzymes, hormones, and other proteinaceous or nonproteinaceous solutes. In some embodiments, the antibody will be purified (1) to greater than 90%, greater than 95%, or greater than 98%, by weight of antibody as determined by the Lowry method, for example, more than 99% by weight, (2) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (3) to homogeneity by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under reducing or nonreducing conditions using Coomassie blue or silver stain. Isolated antibody includes the antibody in situ within recombinant cells since at least one component of the antibody's natural environment will not be present. In some instances, isolated antibody will be prepared by at least one purification step.

As used herein, the terms “treatment,” “treating,” and the like, refer to obtaining a desired pharmacologic and/or physiologic effect. The effect may be prophylactic in terms of completely or partially preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete cure for a disease and/or adverse effect attributable to the disease. “Treatment,” as used herein, covers any treatment of a disease in a mammal, particularly in a human, and includes: (a) preventing the disease from occurring in a subject which may be predisposed to the disease but has not yet been diagnosed as having it; (b) inhibiting the disease, i.e., arresting its development; and (c) relieving the disease, i.e., causing regression of the disease.

The terms “individual,” “subject,” “host,” and “patient,” used interchangeably herein, refer to a mammal, including, but not limited to, murines (rats, mice), non-human primates, humans, canines, felines, ungulates (e.g., equines, bovines, ovines, porcines, caprines), etc.

A “therapeutically effective amount” or “efficacious amount” refers to the amount of an ACVR2A-specific antibody that, when administered to a mammal or other subject for treating a disease, is sufficient to effect such treatment for the disease. The “therapeutically effective amount” will vary depending on the ACVR2A-specific antibody, the disease and its severity and the age, weight, etc., of the subject to be treated.

A “biological sample” encompasses a variety of sample types obtained from an individual and can be used in a diagnostic or monitoring assay. The definition encompasses blood and other liquid samples of biological origin, solid tissue samples such as a biopsy specimen or tissue cultures or cells derived therefrom and the progeny thereof. The definition also includes samples that have been manipulated in any way after their procurement, such as by treatment with reagents, solubilization, or enrichment for certain components, such as polynucleotides. The term “biological sample” encompasses a clinical sample, and also includes cells in culture, cell supernatants, cell lysates, serum, plasma, biological fluid, and tissue samples.

The present disclosure may make use of consensus sequences. If an amino acid sequence is indicated as being “of sequence Y”, where Y is a consensus sequence, the amino acid sequence falls within the consensus sequence. In a consensus sequence, the amino acid “X” can be any amino acid.

Before the present invention is further described, it is to be understood that this invention is not limited to particular embodiments described, as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.

Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges, and are also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the invention.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, the preferred methods and materials are now described. All publications mentioned herein are incorporated herein by reference to disclose and describe the methods and/or materials in connection with which the publications are cited.

It must be noted that as used herein and in the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to “an antibody” includes a plurality of such antibodies and reference to “the ACVR2A-specific antibody” includes reference to one or more ACVR2A-specific antibodies and equivalents thereof known to those skilled in the art, and so forth. It is further noted that the claims may be drafted to exclude any optional element. As such, this statement is intended to serve as antecedent basis for use of such exclusive terminology as “solely,” “only” and the like in connection with the recitation of claim elements, or use of a “negative” limitation.

The publications discussed herein are provided solely for their disclosure prior to the filing date of the present application. Nothing herein is to be construed as an admission that the present invention is not entitled to antedate such publication by virtue of prior invention. Further, the dates of publication provided may be different from the actual publication dates which may need to be independently confirmed.

DETAILED DESCRIPTION

The present disclosure provides antibodies that specifically bind to and block signaling by ACVR2A, i.e., ACVR2A but not ACVR2B. In some embodiments, the antibody may comprise (a) a variable domain comprising: i. heavy chain CDR1, CDR2 and CDR3 regions that are identical the heavy chain CDR1, CDR2 and CDR3 regions of an antibody selected from any of Tables 2A-2F; and ii. light chain CDR1, CDR2 and CDR3 regions that are identical the light chain CDR1, CDR2 and CDR3 regions of the antibody selected from any of Tables 2A-2F; or (b) a variant of the variable domain of (a) that is otherwise identical to the antibody variable domain of (a) except for up to 15 amino acid substitutions in the CDR regions, e.g., up to 15, up to 14, up to 13, up to 12, up to 11, up to 10, up to 9, up to 8, up to 7, up to 6, up to 5, up to 4, up to 3, up to 2 amino acid substitutions in the CDR regions.

In some embodiments, the antibody may comprise: a heavy chain variable domain comprising: a heavy chain framework, a CDR1 region, a CDR2 region, and a CDR3 region of sequence AxxAxWHDTxLD; and a light chain variable domain comprising: a light chain framework, a CDR1 region, a CDR2 region, and a CDR3 region. For example, in some embodiments, the heavy chain variable domain of the antibody may comprise a CDR3 region of sequence ARSATWHDTxLD (SEQ ID NO: 6538) (e.g., ARAANWHDTA/HLD (SEQ ID NO: 6539)), ARAATWHDTxLD (SEQ ID NO: 6540) (e.g., ARAATWHDTH/ALD (SEQ ID NO: 6541)), ARGANWHDTxLD (SEQ ID NO: 6542) (e.g., ARGANWHDTA/HLD (SEQ ID NO: 6543)), ARGATWHDTxLD (SEQ ID NO: 6544) (e.g., ARGATWHDTH/ALD (SEQ ID NO: 6545)), ARSANWHDTxLD (SEQ ID NO: 6546) (e.g., AR/KSANWHDTA/HLD (SEQ ID NO: 6547)) or ARSATWHDTxLD (SEQ ID NO: 6548) (e.g., ARSATWHDTH/ALD (SEQ ID NO: 6549)).

As will be shown below, there is considerable diversity in the heavy chain CDR1, heavy chain CDR2, light chain CDR1, light chain CDR2 and light chain CDR3 regions in the present antibodies. Therefore, consistent with Barrios et al (Mol. Recognit. 2004 17: 332-8) and Bowers et al (J. Biol. Chem. 2013 288: 7688-96) the heavy chain CDR3 is believed primarily responsible for antigen binding in the present antibody.

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6551), and iii. a CDR3 region that has a sequence of ARAANWHDTA/HLD (SEQ ID NO: 6552); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XXYL/VNWY (SEQ ID NO: 6553) (e.g., L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6554)), ii. a CDR2 region that has a sequence of LV/LIYXXXS/NR/LX (SEQ ID NO: 6555)(e.g., LV/LIYA/Y/VA/V/TT/S/NS/NR/LA/H/Q/P (SEQ ID NO: 6556)), and iii. a CDR3 region that has a sequence of QQ/HSY/DXXPL (SEQ ID NO: 6557) (e.g., QQ/HSY/DD/E/S/NL/N/S/TPL (SEQ ID NO: 6558)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6551), and iii. a CDR3 region that has a sequence of ARAATWHDTH/ALD (SEQ ID NO: 6559); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6560) (e.g., L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561)), ii. a CDR2 region that has a sequence of LL/VIYA/YXXS/NR/LX (SEQ ID NO: 6562)(e.g., LL/VIYA/YA/T/VT/S/NS/NR/LA/P/Q (SEQ ID NO: 6563)), and iii. a CDR3 region that has a sequence of QQSY/D/NXXPL (SEQ ID NO: 6564) (e.g., QQSY/D/ND/E/S/NL/S/T/NPL (SEQ ID NO: 6565)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6566), ii. a CDR2 region that has a sequence of WVS/AG/S/NINYNG/SGYT/KS/G (SEQ ID NO: 6567), and iii. a CDR3 region that has a sequence of ARGANWHDTA/HLD (SEQ ID NO: 6543); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6568) (e.g., L/V/S/IS/TYL/VNWY (SEQ ID NO: 6569)), ii. a CDR2 region that has a sequence of LL/VIYAXT/SSR/LX (SEQ ID NO: 6570) (e.g., LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/S/NS/T/N/LPL (SEQ ID NO: 6573)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6574), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6575), and iii. a CDR3 region that has a sequence of ARGATWHDTH/ALD (SEQ ID NO: 6544); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6568) (e.g., L/I/V/SS/TYL/VNWY (SEQ ID NO: 6576)), ii. a CDR2 region that has a sequence of LL/VIYAXT/SSR/LX (SEQ ID NO: 6570) (e.g., LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/S/NT/S/N/LPL (SEQ ID NO: 6577)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYG/SMN/H (SEQ ID NO: 6578), ii. a CDR2 region that has a sequence of WVS/AG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6579), and iii. a CDR3 region that has a sequence of AR/KSANWHDTA/HLD (SEQ ID NO: 6580); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XS/TYL/VNWY (SEQ ID NO: 6568) (e.g., L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561)), ii. a CDR2 region that has a sequence of LL/VIYA/YXT/SS/NR/LX (SEQ ID NO: 6581) (e.g., LL/VIYA/YA/V/TT/SS/NR/LA/H/Q (SEQ ID NO: 6582)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/N/S S/T/L/NPL (SEQ ID NO: 6583)).

In some embodiments, the antibody may comprise a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYS/GMN/H (SEQ ID NO: 6584), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6585), and iii. a CDR3 region that has a sequence of ARSATWHDTH/ALD (SEQ ID NO: 6586); and a light chain variable domain comprising: i. a CDR1 region that has a sequence of XXYL/VNWY (SEQ ID NO: 6587) (e.g., L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6588)), ii. a CDR2 region that has a sequence of LL/VIYA/YXT/SS/NR/LX (SEQ ID NO: 6589) (e.g., LL/VIYA/YA/V/TT/SS/NR/LA/H/Q (SEQ ID NO: 6590)), and iii. a CDR3 region that has a sequence of QQSY/DXXPL (SEQ ID NO: 6572) (e.g., QQSY/DD/E/S/NL/N/T/SPL (SEQ ID NO: 6591)).

In some embodiments the antibody may comprise: a heavy chain variable domain comprising an amino acid sequence that is at least 80% identical to (e.g., at least 90%, at least 95%, at least 98%, at least 99%, or 100% identical to) the amino acid sequence of the heavy chain variable domain of an antibody selected from any of Tables 2A-2F; and a light chain variable domain comprising an amino acid sequence that is at least 80% identical to (e.g., at least 90%, at least 95%, at least 98%, at least 99%, or 100% identical to) the light chain variable domain of the antibody selected from any of Tables 2A-2F.

Tables 2A-2F provides the amino acid sequences of the heavy and light variable domains of some examples of the present antibody.

TABLE 2A
Group I Antibody Sequences
Ab	VH sequence	VL sequence
365_B04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNSGYTSYADSV	PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSDESPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 58)
	NO: 1)
365_B10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILRYLNWYQQK
	SMHWVRQAPGKGLEWVASINYNSGYKGYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSDNLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 59)
	NO: 2)
365_C03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK
	GMHWVRQAPGKGLEWVAGINYNSGYKGYADSV	PGKAPKLVIYATTSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 60)
	NO: 3)
365_C06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQK
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	PGKAPKLLIYAVTSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 61)
	NO: 4)
365_D04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQK
	GMHWVRQAPGKGLEWVAGINYNGGYKSYADSV	PGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 62)
	NO: 5)
365_E04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYKSYADSV	PGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 63)
	NO: 6)
365_F11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK
	SMNWVRQAPGKGLEWVSGINYNSGYKGYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 64)
	NO: 7)
365_G07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK
	GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 65)
	NO: 8)
365_H08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYKSYADSV	PGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 66)
	NO: 9)
366_A02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK
	GMNWVRQAPGKGLEWVASINYNSGYKGYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 67)
	NO: 10)
366_A04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 68)
	NO: 11)
366_D01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK
	GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 69)
	NO: 12)
366 D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 70)
	NO: 13)
366_F10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK
	SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 71)
	NO: 14)
366_G06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTGYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 72)
	NO: 15)
367_B09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 73)
	NO: 16)
367_B11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK
	SMHWVRQAPGKGLEWVANINYNSGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 74)
	NO: 17)
367_C09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 75)
	NO: 18)
367_D11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK
	GMHWVRQAPGKGLEWVSNINYNGGYKSYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 76)
	NO: 19)
367_F06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQK
	GMNWVRQAPGKGLEWVSSINYNSGYTSYADSV	PGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 77)
	NO: 20)
367_H01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 78)
	NO: 21)
368_A02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK
	GMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 79)
	NO: 22)
368_A06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	SMHWVRQAPGKGLEWVAGINYNSGYKGYADSV	PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 80)
	NO: 23)
368_A12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	SMHWVRQAPGKGLEWVSSINYNSGYKGYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 81)
	NO: 24)
368_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQHSYENPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 82)
	NO: 25)
368_B08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK
	GMNWVRQAPGKGLEWVSSINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 83)
	NO: 26)
368_B10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSDELPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 84)
	NO: 27)
368_B11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK
	GMHWVRQAPGKGLEWVSGINYNGGYKSYADSV	PGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 85)
	NO: 28)
368_C09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK
	SMHWVRQAPGKGLEWVSNINYNGGYTGYADSV	PGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 86)
	NO: 29)
368 D09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK
	GMHWVRQAPGKGLEWVAGINYNSGYKSYADSV	PGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 87)
	NO: 30)
368_F02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK
	GMNWVRQAPGKGLEWVASINYNSGYTSYADSV	PGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 88)
	NO: 31)
368_F10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK
	GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 89)
	NO: 32)
369_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 90)
	NO: 33)
369_G10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 91)
	NO: 34)
369_H03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK
	SMHWVRQAPGKGLEWVASINYNSGYKSYADSV	PGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 92)
	NO: 35)
370_B01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVSGINYNGGYKSYADSV	PGKAPKLLIYVASSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 93)
	NO: 36)
370_D06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK
	GMNWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 94)
	NO: 37)
370_G04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVSGINYNGGYTGYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 95)
	NO: 38)
370_H08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 96)
	NO: 39)
371_A04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMNWVRQAPGKGLEWVSSINYNSGYTGYADSV	PGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 97)
	NO: 40)
371_A09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVNWYQQK
	GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 98)
	NO: 41)
371_D07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMNWVRQAPGKGLEWVANINYNGGYKGYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 99)
	NO: 42)
371_D12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK
	GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 100)
	NO: 43)
371_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 101)
	NO: 44)
372_A09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQK
	GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 102)
	NO: 45)
372_B11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQK
	SMHWVRQAPGKGLEWVAGINYNSGYTSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 103)
	NO: 46)
372_E02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK
	GMNWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 104)
	NO: 47)
373_E11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 105)
	NO: 48)
373_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQK
	GMHWVRQAPGKGLEWVAGINYNSGYTSYADSV	PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYXNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 106)
	NO: 49)
374_B02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQK
	SMHWVRQAPGKGLEWVAGINYNSGYTSYADSV	PGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 107)
	NO: 50)
374_F03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQK
	GMNWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 108)
	NO: 51)
375_A04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	PGKAPKLVIYYVNNLPSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 109)
	NO: 52)
375_A11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQK
	GMHWVRQAPGKGLEWVSSINYNSGYKSYADSV	PGKAPKLLIYYVTNLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 110)
	NO: 53)
375_C10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAASSLQSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 111)
	NO: 54)
375_F12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	PGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSDELPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 112)
	NO: 55)
375_H01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQK
	SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	PGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTHLDYWGQGTLVTVSS (SEQ ID	NO: 113)
	NO: 56)
376_G02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISRYLNWYQQK
	GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	PGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTISSL
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	QPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ ID
	ARAANWHDTALDYWGQGTLVTVSS (SEQ ID	NO: 114)
	NO: 57)

Table 3A provides the amino acid sequences of the CDRs of the antibodies shown in Table 2A.

TABLE 3A
CDR sequences for Group I antibodies
Ab	HCDR1	HCDR2	HCDR3	LCDR1	LCDR2	LCDR3
365_B04	SSYGMH	WVASINYNSGYTS	ARAANWHDTALD	LTYLNWY	LLIYAATSRH	QQSDESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	172)	229)	NO:	NO: 343)	NO: 400)
	115)			286)
365_B10	DDYSMH	WVASINYNSGYKG	ARAANWHDTALD	LRYLNWY	LLIYAATSRA	QQSDNLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	173)	230)	NO:	NO: 344)	NO: 401)
	116)			287)
365_C03	SSYGMH	WVAGINYNSGYKG	ARAANWHDTHLD	LTYVNWY	LVIYATTSLA	QQSYNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	174)	231)	NO:	NO: 345)	NO: 402)
	117)			288)
365_C06	SDYGMH	WVSGINYNGGYTS	ARAANWHDTALD	STYVNWY	LLIYAVTSLA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	175)	232)	NO:	NO: 346)	NO: 403)
	118)			289)
365_D04	SDYGMH	WVAGINYNGGYKS	ARAANWHDTALD	SSYLNWY	LVIYAVTSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	176)	233)	NO:	NO: 347)	NO: 404)
	119)			290)
365_E04	DSYGMH	WVASINYNGGYKS	ARAANWHDTALD	LSYVNWY	LLIYAATSLA	QQSYELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	177)	234)	NO:	NO: 348)	NO: 405)
	120)			291)
365_F11	DSYSMN	WVSGINYNSGYKG	ARAANWHDTHLD	ISYVNWY	LLIYAATSRA	QQSYNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	178)	235)	NO:	NO: 349)	NO: 406)
	121)			292)
365_G07	DSYGMH	WVSSINYNGGYTS	ARAANWHDTALD	VSYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	179)	236)	NO:	NO: 350)	NO: 407)
	122)			293)
365_H08	SSYGMH	WVASINYNGGYKS	ARAANWHDTALD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	180)	237)	NO:	NO: 351)	NO: 408)
	123)			294)
366_A02	DSYGMN	WVASINYNSGYKG	ARAANWHDTHLD	VSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	181)	238)	NO:	NO: 352)	NO: 409)
	124)			295)
366_A04	SSYGMN	WVAGINYNGGYTS	ARAANWHDTALD	LTYLNWY	LVIYAATSLA	QQSDDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	182)	239)	NO:	NO: 353)	NO: 410)
	125)			296)
366_D01	SSYGMH	WVSSINYNGGYTG	ARAANWHDTHLD	LTYVNWY	LLIYAATSRA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	183)	240)	NO:	NO: 354)	NO: 411)
	126)			297)
366_D03	DSYGMH	WVSSINYNGGYTG	ARAANWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	184)	241)	NO:	NO: 355)	NO: 412)
	127)			298)
366_F10	DSYSMN	WVAGINYNGGYTG	ARAANWHDTHLD	VSYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	185)	242)	NO:	NO: 356)	NO: 413)
	128)			299)
366_G06	SSYGMH	WVASINYNGGYTG	ARAANWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	186)	243)	NO:	NO: 357)	NO: 414)
	129)			300)
367_B09	DSYGMH	WVASINYNGGYTS	ARAANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	187)	244)	NO:	NO: 358)	NO: 415)
	130)			301)
367_B11	SDYSMH	WVANINYNSGYTS	ARAANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	188)	245)	NO:	NO: 359)	NO: 416)
	131)			302)
367_C09	DSYGMH	WVASINYNGGYTS	ARAANWHDTHLD	LVIYAATSRH	LSYVNWY	QQSYNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	189)	246)	NO:	NO: 360)	NO: 417)
	132)			303)
367_D11	DSYGMH	WVSNINYNGGYKS	ARAANWHDTALD	ISYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	190)	247)	NO:	NO: 361)	NO: 418)
	133)			304)
367_F06	SSYGMN	WVSSINYNSGYTS	ARAANWHDTALD	SSYVNWY	LLIYAVTSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	191)	248)	NO:	NO: 362)	NO: 419)
	134)			305)
367_H01	DSYGMN	WVSGINYNGGYKS	ARAANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	192)	249)	NO:	NO: 363)	NO: 420)
	135)			306)
368_A02	DSYGMN	WVAGINYNGGYKS	ARAANWHDTHLD	ISYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	193)	250)	NO:	NO: 364)	NO: 421)
	136)			307)
368_A06	DSYSMH	WVAGINYNSGYKG	ARAANWHDTHLD	LSYVNWY	LLIYAATSRH	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	194)	251)	NO:	NO: 365)	NO: 422)
	137)			308)
368_Al2	DSYSMH	WVSSINYNSGYKG	ARAANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	195)	252)	NO:	NO: 366)	NO: 423)
	138)			309)
368_B03	DDYGMN	WVSGINYNGGYTS	ARAANWHDTALD	LTYLNWY	LVIYAATSLA	QHSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	196)	253)	NO:	NO: 367)	NO: 424)
	139)			310)
368_B08	DSYGMN	WVSSINYNGGYTS	ARAANWHDTHLD	LTYVNWY	LVIYAATSRA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	197)	254)	NO:	NO: 368)	NO: 425)
	140)			311)
368_B10	DSYGMH	WVASINYNGGYTS	ARAANWHDTALD	LTYLNWY	LVIYAATSRA	QQSDELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	198)	255)	NO:	NO: 369)	NO: 426)
	141)			312)
368_B11	DSYGMH	WVSGINYNGGYKS	ARAANWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	199)	256)	NO:	NO: 370)	NO: 427)
	142)			313)
368_C09	SSYSMH	WVSNINYNGGYTG	ARAANWHDTHLD	LTYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	200)	257)	NO:	NO: 371)	NO: 428)
	143)			314)
368_D09	DSYGMH	WVAGINYNSGYKS	ARAANWHDTHLD	VSYVNWY	LLIYAATSLA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	201)	258)	NO:	NO: 372)	NO: 429)
	144)			315)
368_F02	SSYGMN	WVASINYNSGYTS	ARAANWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSYSLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	202)	259)	NO:	NO: 373)	NO: 430)
	145)			316)
368_F10	SSYGMN	WVAGINYNSGYTS	ARAANWHDTHLD	VSYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	203)	260)	NO:	NO: 374)	NO: 431)
	146)			317)
369_B03	SSYGMH	WVAGINYNGGYTS	ARAANWHDTALD	LTYVNWY	LVIYAATSLA	QQSYELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	204)	261)	NO:	NO: 375)	NO: 432)
	147)			318)
369_G10	SSYGMH	WVASINYNGGYTS	ARAANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	205)	262)	NO:	NO: 376)	NO: 433)
	148)			319)
369_H03	SSYSMH	WVASINYNSGYKS	ARAANWHDTALD	VSYLNWY	LLIYATTSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	206)	263)	NO:	NO: 377)	NO: 434)
	149)			320)
370_B01	DDYGMH	WVSGINYNGGYKS	ARAANWHDTALD	LSYVNWY	LLIYVASSRA	QQSYSLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	207)	264)	NO:	NO: 378)	NO: 435)
	150)			321)
370_D06	SSYGMN	WVASINYNGGYTS	ARAANWHDTHLD	ISYLNWY	LVIYAATSLA	QQSYSSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	208)	265)	NO:	NO: 379)	NO: 436)
	151)			322)
370_G04	SSYGMH	WVSGINYNGGYTG	ARAANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	209)	266)	NO:	NO: 380)	NO: 437)
	152)			323)
370_H08	SSYGMH	WVASINYNGGYTS	ARAANWHDTHLD	LSYVNWY	LLIYAATSRH	QQSYSLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	210)	267)	NO:	NO: 381)	NO: 438)
	153)			324)
371_A04	D SYGMN	WVSSINYNSGYTG	ARAANWHDTALD	LTYLNWY	LLIYAVTSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	211)	268)	NO:	NO: 382)	NO: 439)
	154)			325)
371_A09	SSYGMN	WVSGINYNGGYKS	ARAANWHDTALD	VTYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	212)	269)	NO:	NO: 383)	NO: 440)
	155)			326)
371_D07	DDYGMN	WVANINYNGGYKG	ARAANWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	213)	270)	NO:	NO: 384)	NO: 441)
	156)			327)
371_D12	DSYGMN	WVSGINYNGGYKS	ARAANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	214)	271)	NO:	NO: 385)	NO: 442)
	157)			328)
371_H02	DDYSMN	WVSGINYNGGYKS	ARAANWHDTHLD	ISYLNWY	LVIYAATSLA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	215)	272)	NO:	NO: 386)	NO: 443)
	158)			329)
372_A09	DSYGMN	WVSGINYNGGYTS	ARAANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	216)	273)	NO:	NO: 387)	NO: 444)
	159)			330)
372_B11	SSYSMH	WVAGINYNSGYTS	ARAANWHDTHLD	LTYVNWY	LVIYAATSLA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	217)	274)	NO:	NO: 388)	NO: 445)
	160)			331)
372_E02	SSYGMN	WVASINYNGGYTS	ARAANWHDTALD	ISYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	218)	275)	NO:	NO: 389)	NO: 446)
	161)			332)
373_E11	DSYGMH	WVASINYNGGYTS	ARAANWHDTALD	VSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	219)	276)	NO:	NO: 390)	NO: 447)
	162)			333)
373_H02	SSYGMH	WVAGINYNSGYTS	ARAANWHDTALD	VSYVNWY	LLIYAATSRH	QQSYXNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	220)	277)	NO:	NO: 391)	NO: 448)
	163)			334)
374_B02	DSYSMH	WVAGINYNSGYTS	ARAANWHDTHLD	ISYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	221)	278)	NO:	NO: 392)	NO: 449)
	164)			335)
374_F03	SSYGMN	WVASINYNGGYTS	ARAANWHDTHLD	ISYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	222)	279)	NO:	NO: 393)	NO: 450)
	165)			336)
375_A04	DSYGMN	WVAGINYNGGYKS	ARAANWHDTALD	LTYLNWY	LVIYYVNNLP	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	223)	280)	NO:	NO: 394)	NO: 451)
	166)			337)
375_A11	SDYGMH	WVSSINYNSGYKS	ARAANWHDTALD	VSYLNWY	LLIYYVTNLA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	224)	281)	NO:	NO: 395)	NO: 452)
	167)			338)
375_C10	SSYGMH	WVASINYNGGYTS	ARAANWHDTALD	STYLNWY	LVIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	225)	282)	NO:	NO: 396)	NO: 453)
	168)			339)
375_F12	DSYGMH	WVASINYNGGYTS	ARAANWHDTALD	LTYLNWY	LVIYAATSRA	QQSDELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	226)	283)	NO:	NO: 397)	NO: 454)
	169)			340)
375_H01	SDYSMN	WVAGINYNSGYTS	ARAANWHDTHLD	LTYLNWY	LLIYAATSRH	QQSYSNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	227)	284)	NO:	NO: 398)	NO: 455)
	170)			341)
376_G02	SDYGMN	WVSGINYNGGYTS	ARAANWHDTALD	SRYLNWY	LVIYAATSLA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID	NO: 228)	285)	NO:	NO: 399)	NO: 456)
	171)			342)

The consensus sequences for each of these CDRs shown in FIG. 3A are as follows:

HCDR1:
(SEQ ID NO: 6550)
D/SS/DYG/SMH/N
HCDR2:
(SEQ ID NO: 6551)
WVA/SS/G/NINYNG/SGYT/KS/G
HCDR3:
(SEQ ID NO: 6552)
ARAANWHDTA/HLD
LCDR1:
(SEQ ID NO: 6554)
L/V/I/SS/T/RYL/VNWY
LCDR2:
(SEQ ID NO: 6592)
LV/LIYA/Y/VA/V/TT/S/NS/NR/LA/H/Q/P
LCDR3
(SEQ ID NO: 6593)
QQ/HSY/DD/E/S/NL/N/S/TPL

TABLE 2B
Group II Antibody Sequences
Ab	VH sequence	VL sequence
365_A05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 528)
	NO: 457)
365_B08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNSGYKGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 529)
	NO: 458)
365_B12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAVTSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 530)
	NO: 459)
365_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMHWVRQAPGKGLEWVASINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 531)
	NO: 460)
365_D08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ
	SMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 532)
	NO: 461)
365_E06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 533)
	NO: 462)
365_F10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 534)
	NO: 463)
365_G06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 535)
	NO: 464)
365_G08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 536)
	NO: 465)
366_B09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNSGYKSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 537)
	NO: 466)
366_C05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 538)
	NO: 467)
366_E07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDNSPLTFGGGTKVEIK (SEQ
	ARAATWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 539)
	NO: 468)
366_G02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDDNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 540)
	NO: 469)
366_H01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMHWVRQAPGKGLEWVANINYNGGYTSYADSV	KPGKAPKLVIYATTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 541)
	NO: 470)
367_C06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMHWVRQAPGKGLEWVASINYNGGYKSYADSV	KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 542)
	NO: 471)
367_C12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYATTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 543)
	NO: 472)
367_E08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 544)
	NO: 473)
367_E10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 545)
	NO: 474)
367_F08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSSINYNSGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSNELPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 546)
	NO: 475)
367_F10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 547)
	NO: 476)
367_G03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMHWVRQAPGKGLEWVANINYNGGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 548)
	NO: 477)
367_G11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 549)
	NO: 478)
367_H08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMNWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 550)
	NO: 479)
368_B04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 551)
	NO: 480)
368_B12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 552)
	NO: 481)
368_C04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 553)
	NO: 482)
368_C07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 554)
	NO: 483)
368_C12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 555)
	NO: 484)
368_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ
	SMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 556)
	NO: 485)
368_D06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 557)
	NO: 486)
368 D07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTGYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 558)
	NO: 487)
368_E05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMHWVRQAPGKGLEWVSSINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 559)
	NO: 488)
368_E08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVANINYNSGYTGYADSV	KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 560)
	NO: 489)
368_G11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDNTPLTFGGGTKVEIK (SEQ
	ARAATWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 561)
	NO: 490)
368_H03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMHWVRQAPGKGLEWVASINYNGGYTGYADSV	KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 562)
	NO: 491)
369_A04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYKSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 563)
	NO: 492)
369_A12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMHWVRQAPGKGLEWVASINYNSGYTGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 564)
	NO: 493)
369_B07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVANINYNGGYKSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 565)
	NO: 494)
369_B08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 566)
	NO: 495)
369_C06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMHWVRQAPGKGLEWVSSINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 567)
	NO: 496)
369_C09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 568)
	NO: 497)
369_C11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 569)
	NO: 498)
369_E03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 570)
	NO: 499)
370_B06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 571)
	NO: 500)
370_B07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMHWVRQAPGKGLEWVANINYNSGYKSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 572)
	NO: 501)
370_E12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 573)
	NO: 502)
370_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 574)
	NO: 503)
371_A05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVSNINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDNLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 575)
	NO: 504)
371_B02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 576)
	NO: 505)
371_B11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMHWVRQAPGKGLEWVASINYNSGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 577)
	NO: 506)
371_C02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNSGYTGYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 578)
	NO: 507)
371_D05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 579)
	NO: 508)
371_F07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 580)
	NO: 509)
371_G07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 581)
	NO: 510)
372_D07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 582)
	NO: 511)
373_B01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 583)
	NO: 512)
373_D11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMHWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 584)
	NO: 513)
373_G06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVASINYNSGYTGYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 585)
	NO: 514)
374_A10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 586)
	NO: 515)
374_A12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 587)
	NO: 516)
374_B01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 588)
	NO: 517)
374_B07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYKSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 589)
	NO: 518)
374_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 590)
	NO: 519)
375_C03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 591)
	NO: 520)
375_C05	EVQLLESGGGLVQPGGSLRLSCAASGFTFXSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVASINYNGGYKGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 592)
	NO: 521)
375_D02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 593)
	NO: 522)
375_G08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 594)
	NO: 523)
375_H04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVAGINYNSGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 595)
	NO: 524)
376_D08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVANINYNSGYKSYADSV	KPGKAPKLVIYYANNRPSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ
	ARAATWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 596)
	NO: 525)
376_F09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMHWVRQAPGKGLEWVSSINYNGGYKSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 597)
	NO: 526)
376_H12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARAATWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 598)
	NO: 527)

Table 3B provides the amino acid sequences of the CDRs of the antibodies shown in Table 2B.

TABLE 3B
CDR sequences for Group II antibodies
Ab	HCDR1	HCDR2	HCDR3	LCDR1	LCDR2	LCDR3
365_A05	SSYGMH	WVSSINYNGGYTS	ARAATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 670)	(SEQ ID NO: 742)	(SEQ ID NO: 813)	(SEQ ID NO: 884)	(SEQ ID NO: 955)
	NO: 599)
365_B08	DSYGMN	WVSNINYNSGYKG	ARAATWHDTHLD	VTYLNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 671)	(SEQ ID NO: 743)	(SEQ ID NO: 814)	(SEQ ID NO: 885)	(SEQ ID NO: 956)
	NO: 600)
365_B12	SDYGMH	WVSGINYNGGYTS	ARAATWHDTHLD	STYVNWY	LLIYAVTSLH	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 672)	(SEQ ID NO: 744)	(SEQ ID NO: 815)	(SEQ ID NO: 886)	(SEQ ID NO: 957)
	NO: 601)
365_D03	DDYSMH	WVASINYNGGYKS	ARAATWHDTHLD	VSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 673)	(SEQ ID NO: 745)	(SEQ ID NO: 816)	(SEQ ID NO: 887)	(SEQ ID NO: 958)
	NO: 602)
365_D08	DSYSMH	WVSSINYNGGYTS	ARAATWHDTHLD	ITYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 674)	(SEQ ID NO: 746)	(SEQ ID NO: 817)	(SEQ ID NO: 888)	(SEQ ID NO: 959)
	NO: 603)
365_E06	DSYGMN	WVSGINYNGGYTG	ARAATWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYNTPL
	(SEQ ID	(SEQ ID NO: 675)	(SEQ ID NO: 747)	(SEQ ID NO: 818)	(SEQ ID NO: 889)	(SEQ ID NO: 960)
	NO: 604)
365_F10	DDYGMH	WVSGINYNGGYTS	ARAATWHDTHLD	VTYVNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 676)	(SEQ ID NO: 748)	(SEQ ID NO: 819)	(SEQ ID NO: 890)	(SEQ ID NO: 961)
	NO: 605)
365_G06	DSYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	LSYLNWY	LLIYAATSLA	QQSDSTPL
	(SEQ ID	(SEQ ID NO: 677)	(SEQ ID NO: 749)	(SEQ ID NO: 820)	(SEQ ID NO: 891)	(SEQ ID NO: 962)
	NO: 606)
365_G08	SSYGMH	WVASINYNGGYTS	ARAATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYETPL
	(SEQ ID	(SEQ ID NO: 678)	(SEQ ID NO: 750)	(SEQ ID NO: 821)	(SEQ ID NO: 892)	(SEQ ID NO: 963)
	NO: 607)
366_B09	SDYGMH	WVSSINYNSGYKS	ARAATWHDTHLD	LTYLNWY	LVIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 679)	(SEQ ID NO: 751)	(SEQ ID NO: 822)	(SEQ ID NO: 893)	(SEQ ID NO: 964)
	NO: 608)
366_C05	DDYGMH	WVSSINYNGGYTG	ARAATWHDTHLD	ISYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 680)	(SEQ ID NO: 752)	(SEQ ID NO: 823)	(SEQ ID NO: 894)	(SEQ ID NO: 965)
	NO: 609)
366_E07	DSYGMH	WVAGINYNGGYTS	ARAATWHDTALD	LTYLNWY	LVIYAATSRH	QQSDNSPL
	(SEQ ID	(SEQ ID NO: 681)	(SEQ ID NO: 753)	(SEQ ID NO: 824)	(SEQ ID NO: 895)	(SEQ ID NO: 966)
	NO: 610)
366_G02	DSYGMH	WVSSINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRH	QQSDDNPL
	(SEQ ID	(SEQ ID NO: 682)	(SEQ ID NO: 754)	(SEQ ID NO: 825)	(SEQ ID NO: 896)	(SEQ ID NO: 967)
	NO: 611)
366_H01	DDYSMH	WVANINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LVIYATTSRH	QQSYESPL
	(SEQ ID	(SEQ ID NO: 683)	(SEQ ID NO: 755)	(SEQ ID NO: 826)	(SEQ ID NO: 897)	(SEQ ID NO: 968)
	NO: 612)
367_C06	DSYSMH	WVASINYNGGYKS	ARAATWHDTHLD	LTYLNWY	LVIYAATSLH	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 684)	(SEQ ID NO: 756)	(SEQ ID NO: 827)	(SEQ ID NO: 898)	(SEQ ID NO: 969)
	NO: 613)
367_C12	SSYGMH	WVSGINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYATTSRH	QQSYESPL
	(SEQ ID	(SEQ ID NO: 685)	(SEQ ID NO: 757)	(SEQ ID NO: 828)	(SEQ ID NO: 899)	(SEQ ID NO: 970)
	NO: 614)
367_E08	SDYGMN	WVASINYNGGYTS	ARAATWHDTHLD	LSYLNWY	LLIYATTSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 686)	(SEQ ID NO: 758)	(SEQ ID NO: 829)	(SEQ ID NO: 900)	(SEQ ID NO: 971)
	NO: 615)
367_E10	SSYGMH	WVSSINYNGGYTG	ARAATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 687)	(SEQ ID NO: 759)	(SEQ ID NO: 830)	(SEQ ID NO: 901)	(SEQ ID NO: 972)
	NO: 616)
367_F08	SSYGMH	WVSSINYNSGYTS	ARAATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSNELPL
	(SEQ ID	(SEQ ID NO: 688)	(SEQ ID NO: 760)	(SEQ ID NO: 831)	(SEQ ID NO: 902)	(SEQ ID NO: 973)
	NO: 617)
367_F10	DSYGMN	WVSGINYNSGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 689)	(SEQ ID NO: 761)	(SEQ ID NO: 832)	(SEQ ID NO: 903)	(SEQ ID NO: 974)
	NO: 618)
367_G03	DSYSMH	WVANINYNGGYTS	ARAATWHDTHLD	VSYVNWY	LVIYAATSRH	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 690)	(SEQ ID NO: 762)	(SEQ ID NO: 833)	(SEQ ID NO: 904)	(SEQ ID NO: 975)
	NO: 619)
367_G11	SSYGMH	WVASINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRH	QQSDDSPL
	(SEQ ID	(SEQ ID NO: 691)	(SEQ ID NO: 763)	(SEQ ID NO: 834)	(SEQ ID NO: 905)	(SEQ ID NO: 976)
	NO: 620)
367_H08	DSYGMN	WVSSINYNGGYTS	ARAATWHDTHLD	LTYVNWY	LLIYAATSRH	QQSYNLPL
	(SEQ ID	(SEQ ID NO: 692)	(SEQ ID NO: 764)	(SEQ ID NO: 835)	(SEQ ID NO: 906)	(SEQ ID NO: 977)
	NO: 621)
368_B04	DSYGMH	WVSSINYNGGYTS	ARAATWHDTHLD	VSYLNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 693)	(SEQ ID NO: 765)	(SEQ ID NO: 836)	(SEQ ID NO: 907)	(SEQ ID NO: 978)
	NO: 622)
368_B12	DSYGMH	WVSGINYNSGYTS	ARAATWHDTHLD	VSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 694)	(SEQ ID NO: 766)	(SEQ ID NO: 837)	(SEQ ID NO: 908)	(SEQ ID NO: 979)
	NO: 623)
368_C04	DSYGMH	WVSNINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 695)	(SEQ ID NO: 767)	(SEQ ID NO: 838)	(SEQ ID NO: 909)	(SEQ ID NO: 980)
	NO: 624)
368_C07	SSYGMH	WVAGINYNSGYTS	ARAATWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 696)	(SEQ ID NO: 768)	(SEQ ID NO: 839)	(SEQ ID NO: 910)	(SEQ ID NO: 981)
	NO: 625)
368_C12	DSYGMH	WVASINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSDSNPL
	(SEQ ID	(SEQ ID NO: 697)	(SEQ ID NO: 769)	(SEQ ID NO: 840)	(SEQ ID NO: 911)	(SEQ ID NO: 982)
	NO: 626)
368_D03	SDYSMH	WVASINYNGGYTS	ARAATWHDTHLD	ITYVNWY	LLIYATTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 698)	(SEQ ID NO: 770)	(SEQ ID NO: 841)	(SEQ ID NO: 912)	(SEQ ID NO: 983)
	NO: 627)
368_D06	SSYGMN	WVSNINYNGGYTG	ARAATWHDTHLD	LSYVNWY	LVIYAATSRH	QQSYENPL
	(SEQ ID	(SEQ ID NO: 699)	(SEQ ID NO: 771)	(SEQ ID NO: 842)	(SEQ ID NO: 913)	(SEQ ID NO: 984)
	NO: 628)
368_D07	DSYGMH	WVASINYNGGYTG	ARAATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 700)	(SEQ ID NO: 772)	(SEQ ID NO: 843)	(SEQ ID NO: 914)	(SEQ ID NO: 985)
	NO: 629)
368_E05	DSYSMH	WVSSINYNGGYKS	ARAATWHDTHLD	LSYLNWY	LVIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 701)	(SEQ ID NO: 773)	(SEQ ID NO: 844)	(SEQ ID NO: 915)	(SEQ ID NO: 986)
	NO: 630)
368_E08	DSYGMH	WVANINYNSGYTG	ARAATWHDTHLD	LSYVNWY	LVIYAATSLH	QQSYETPL
	(SEQ ID	(SEQ ID NO: 702)	(SEQ ID NO: 774)	(SEQ ID NO: 845)	(SEQ ID NO: 916)	(SEQ ID NO: 987)
	NO: 631)
368_G11	DSYGMH	WVSGINYNSGYKS	ARAATWHDTALD	LTYLNWY	LLIYAATSRA	QQSDNTPL
	(SEQ ID	(SEQ ID NO: 703)	(SEQ ID NO: 775)	(SEQ ID NO: 846)	(SEQ ID NO: 917)	(SEQ ID NO: 988)
	NO: 632)
368_H03	DDYSMH	WVASINYNGGYTG	ARAATWHDTHLD	LSYVNWY	LVIYAVTSRH	QQSYSNPL
	(SEQ ID	(SEQ ID NO: 704)	(SEQ ID NO: 776)	(SEQ ID NO: 847)	(SEQ ID NO: 918)	(SEQ ID NO: 989)
	NO: 633)
369_A04	DSYGMH	WVASINYNGGYKS	ARAATWHDTHLD	VSYVNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 705)	(SEQ ID NO: 777)	(SEQ ID NO: 848)	(SEQ ID NO: 919)	(SEQ ID NO: 990)
	NO: 634)
369_A12	SSYSMH	WVASINYNSGYTG	ARAATWHDTHLD	LTYLNWY	LLIYAATSRH	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 706)	(SEQ ID NO: 778)	(SEQ ID NO: 849)	(SEQ ID NO: 920)	(SEQ ID NO: 991)
	NO: 635)
369_B07	DSYGMH	WVANINYNGGYKS	ARAATWHDTHLD	VSYVNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 707)	(SEQ ID NO: 779)	(SEQ ID NO: 850)	(SEQ ID NO: 921)	(SEQ ID NO: 992)
	NO: 636)
369_B08	DSYGMH	WVSSINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 708)	(SEQ ID NO: 780)	(SEQ ID NO: 851)	(SEQ ID NO: 922)	(SEQ ID NO: 993)
	NO: 637)
369_C06	SSYSMH	WVSSINYNGGYKS	ARAATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 709)	(SEQ ID NO: 781)	(SEQ ID NO: 852)	(SEQ ID NO: 923)	(SEQ ID NO: 994)
	NO: 638)
369_C09	SSYGMH	WVSSINYNGGYTG	ARAATWHDTHLD	VSYLNWY	LVIYAATSRH	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 710)	(SEQ ID NO: 782)	(SEQ ID NO: 853)	(SEQ ID NO: 924)	(SEQ ID NO: 995)
	NO: 639)
369_C11	SDYGMH	WVAGINYNGGYTG	ARAATWHDTHLD	LSYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 711)	(SEQ ID NO: 783)	(SEQ ID NO: 854)	(SEQ ID NO: 925)	(SEQ ID NO: 996)
	NO: 640)
369_E03	SSYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYAATSLA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 712)	(SEQ ID NO: 784)	(SEQ ID NO: 855)	(SEQ ID NO: 926)	(SEQ ID NO: 997)
	NO: 641)
370_B06	SSYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 713)	(SEQ ID NO: 785)	(SEQ ID NO: 856)	(SEQ ID NO: 927)	(SEQ ID NO: 998)
	NO: 642)
370_B07	SSYGMH	WVANINYNSGYKS	ARAATWHDTHLD	LTYVNWY	LLIYAATSRH	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 714)	(SEQ ID NO: 786)	(SEQ ID NO: 857)	(SEQ ID NO: 928)	(SEQ ID NO: 999)
	NO: 643)
370_E12	DSYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 715)	(SEQ ID NO: 787)	(SEQ ID NO: 858)	(SEQ ID NO: 929)	(SEQ ID NO: 1000)
	NO: 644)
370_H05	SSYGMH	WVSNINYNGGYTS	ARAATWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSDSLPL
	(SEQ ID	(SEQ ID NO: 716)	(SEQ ID NO: 788)	(SEQ ID NO: 859)	(SEQ ID NO: 930)	(SEQ ID NO: 1001)
	NO: 645)
371_A05	SSYGMH	WVSNINYNGGYKS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSDNLPL
	(SEQ ID	(SEQ ID NO: 717)	(SEQ ID NO: 789)	(SEQ ID NO: 860)	(SEQ ID NO: 931)	(SEQ ID NO: 1002)
	NO: 646)
371_B02	DSYGMN	WVSNINYNGGYTS	ARAATWHDTHLD	LTYVNWY	LVIYAATSLA	QQSYNNPL
	(SEQ ID	(SEQ ID NO: 718)	(SEQ ID NO: 790)	(SEQ ID NO: 861)	(SEQ ID NO: 932)	(SEQ ID NO: 1003)
	NO: 647)
371_B11	SSYSMH	WVASINYNSGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 719)	(SEQ ID NO: 791)	(SEQ ID NO: 862)	(SEQ ID NO: 933)	(SEQ ID NO: 1004)
	NO: 648)
371_C02	DSYGMH	WVAGINYNSGYTG	ARAATWHDTHLD	LTYVNWY	LLIYAASSLQ	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 720)	(SEQ ID NO: 792)	(SEQ ID NO: 863)	(SEQ ID NO: 934)	(SEQ ID NO: 1005)
	NO: 649)
371_D05	DDYGMH	WVSGINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAASSLQ	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 721)	(SEQ ID NO: 793)	(SEQ ID NO: 864)	(SEQ ID NO: 935)	(SEQ ID NO: 1006)
	NO: 650)
371_F07	SSYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSDSNPL
	(SEQ ID	(SEQ ID NO: 722)	(SEQ ID NO: 794)	(SEQ ID NO: 865)	(SEQ ID NO: 936)	(SEQ ID NO: 1007)
	NO: 651)
371_G07	SDYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYSLPL
	(SEQ ID	(SEQ ID NO: 723)	(SEQ ID NO: 795)	(SEQ ID NO: 866)	(SEQ ID NO: 937)	(SEQ ID NO: 1008)
	NO: 652)
372_D07	SSYGMN	WVAGINYNGGYTS	ARAATWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 724)	(SEQ ID NO: 796)	(SEQ ID NO: 867)	(SEQ ID NO: 938)	(SEQ ID NO: 1009)
	NO: 653)
373_B01	DSYGMH	WVSGINYNGGYKS	ARAATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 725)	(SEQ ID NO: 797)	(SEQ ID NO: 868)	(SEQ ID NO: 939)	(SEQ ID NO: 1010)
	NO: 654)
373_D11	SSYGMH	WVAGINYNGGYTS	ARAATWHDTHLD	LTYVNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 726)	(SEQ ID NO: 798)	(SEQ ID NO: 869)	(SEQ ID NO: 940)	(SEQ ID NO: 1011)
	NO: 655)
373_G06	SSYGMH	WVASINYNSGYTG	ARAATWHDTHLD	LSYVNWY	LLIYAATSLA	QQSYNLPL
	(SEQ ID	(SEQ ID NO: 727)	(SEQ ID NO: 799)	(SEQ ID NO: 870)	(SEQ ID NO: 941)	(SEQ ID NO: 1012)
	NO: 656)
374_A10	SSYGMH	WVSGINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 728)	(SEQ ID NO: 800)	(SEQ ID NO: 871)	(SEQ ID NO: 942)	(SEQ ID NO: 1013)
	NO: 657)
374_A12	DSYGMH	WVSSINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSDSNPL
	(SEQ ID	(SEQ ID NO: 729)	(SEQ ID NO: 801)	(SEQ ID NO: 872)	(SEQ ID NO: 943)	(SEQ ID NO: 1014)
	NO: 658)
374_B01	DSYGMH	WVAGINYNSGYTS	ARAATWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 730)	(SEQ ID NO: 802)	(SEQ ID NO: 873)	(SEQ ID NO: 944)	(SEQ ID NO: 1015)
	NO: 659)
374_B07	SSYGMH	WVSSINYNGGYKS	ARAATWHDTHLD	ISYLNWY	LLIYAATSLA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 731)	(SEQ ID NO: 803)	(SEQ ID NO: 874)	(SEQ ID NO: 945)	(SEQ ID NO: 1016)
	NO: 660)
374_H02	SSYGMH	WVASINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 732)	(SEQ ID NO: 804)	(SEQ ID NO: 875)	(SEQ ID NO: 946)	(SEQ ID NO: 1017)
	NO: 661)
375_C03	DSYSMH	WVSGINYNGGYTS	ARAATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 733)	(SEQ ID NO: 805)	(SEQ ID NO: 876)	(SEQ ID NO: 947)	(SEQ ID NO: 1018)
	NO: 662)
375_C05	XSYGMN	WVASINYNGGYKG	ARAATWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 734)	(SEQ ID NO: 806)	(SEQ ID NO: 877)	(SEQ ID NO: 948)	(SEQ ID NO: 1019)
	NO: 663)
375_D02	SSYSMN	WVSNINYNGGYTS	ARAATWHDTHLD	LTYLNWY	LLIYAASSLQ	QQSYELPL
	(SEQ ID	(SEQ ID NO: 735)	(SEQ ID NO: 807)	(SEQ ID NO: 878)	(SEQ ID NO: 949)	(SEQ ID NO: 1020)
	NO: 664)
375_G08	SSYGMH	WVSGINYNGGYTS	ARAATWHDTHLD	SSYVNWY	LLIYAVTSRA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 736)	(SEQ ID NO: 808)	(SEQ ID NO: 879)	(SEQ ID NO: 950)	(SEQ ID NO: 1021)
	NO: 665)
375_H04	SSYGMH	WVAGINYNSGYTG	ARAATWHDTHLD	LSYLNWY	LVIYAATSRA	QQSYSNPL
	(SEQ ID	(SEQ ID NO: 737)	(SEQ ID NO: 809)	(SEQ ID NO: 880)	(SEQ ID NO: 951)	(SEQ ID NO: 1022)
	NO: 666)
376_D08	DSYGMN	WVANINYNSGYKS	ARAATWHDTALD	LTYLNWY	LVIYYANNRP	QQSYSNPL
	(SEQ ID	(SEQ ID NO: 738)	(SEQ ID NO: 810)	(SEQ ID NO: 881)	(SEQ ID NO: 952)	(SEQ ID NO: 1023)
	NO: 667)
376_F09	DSYSMH	WVSSINYNGGYKS	ARAATWHDTHLD	LTYVNWY	LLIYAVTSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 739)	(SEQ ID NO: 811)	(SEQ ID NO: 882)	(SEQ ID NO: 953)	(SEQ ID NO: 1024)
	NO: 668)
376_H12	SDYGMH	WVASINYNGGYTS	ARAATWHDTHLD	ITYLNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 740)	(SEQ ID NO: 812)	(SEQ ID NO: 883)	(SEQ ID NO: 954)	(SEQ ID NO: 1025)
	NO: 669)

The consensus sequences for each of these CDRs shown in FIG. 3B are as follows:

HCDR1:
(SEQ ID NO: 6550)
D/SS/DYG/SMH/N
HCDR2:
(SEQ ID NO: 6551)
WVA/SS/G/NINYNG/SGYT/KS/G
HCDR3:
(SEQ ID NO: 6559)
ARAATWHDTH/ALD
LCDR1:
(SEQ ID NO: 6561)
L/V/I/SS/TYL/VNWY
LCDR2:
(SEQ ID NO: 6563)
LL/VIYA/YA/T/VT/S/NS/NR/LA/P/Q
LCDR3:
(SEQ ID NO: 6565)
QQSY/D/ND/E/S/NL/S/T/NPL

TABLE 2C
Group III Antibody Sequences
Ab	VH sequence	VL sequence
365_C05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1205)
	NO: 1026)
365_E10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYKGYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1206)
	NO: 1027)
365_E12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1207)
	NO: 1028)
365_F02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1208)
	NO: 1029)
365_F03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1209)
	NO: 1030)
365_G03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNSGYKGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1210)
	NO: 1031)
365_G04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1211)
	NO: 1032)
365_G05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYKGYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1212)
	NO: 1033)
365_G09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1213)
	NO: 1034)
365_H07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1214)
	NO: 1035)
366_A06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	SMNWVRQAPGKGLEWVASINYNGGYKSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1215)
	NO: 1036)
366_A08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1216)
	NO: 1037)
366_B05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1217)
	NO: 1038)
366_B07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1218)
	NO: 1039)
366_E01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1219)
	NO: 1040)
366_E08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1220)
	NO: 1041)
366_F02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYTGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1221)
	NO: 1042)
366_G12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVSGINYNSGYKGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1222)
	NO: 1043)
366_H04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1223)
	NO: 1044)
367_A03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYATTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1224)
	NO: 1045)
367_A06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMNWVRQAPGKGLEWVASINYNGGYKGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1225)
	NO: 1046)
367_A08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1226)
	NO: 1047)
367_A10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ
	GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1227)
	NO: 1048)
367_A12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAATSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1228)
	NO: 1049)
367_B01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1229)
	NO: 1050)
367_B04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1230)
	NO: 1051)
367_B12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYKSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1231)
	NO: 1052)
367_C07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1232)
	NO: 1053)
367_C10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1233)
	NO: 1054)
367_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1234)
	NO: 1055)
367_D06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1235)
	NO: 1056)
367_D08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1236)
	NO: 1057)
367_D12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1237)
	NO: 1058)
367_E05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1238)
	NO: 1059)
367_F01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYKSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1239)
	NO: 1060)
367_G01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMNWVRQAPGKGLEWVASINYNSGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1240)
	NO: 1061)
367_G04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1241)
	NO: 1062)
367_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMNWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1242)
	NO: 1063)
367_H03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVNWYQQ
	GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1243)
	NO: 1064)
368_A03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTGYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1244)
	NO: 1065)
368_A04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1245)
	NO: 1066)
368_B09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYKGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1246)
	NO: 1067)
368_C02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYVNWYQQ
	SMNWVRQAPGKGLEWVANINYNGGYKGYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1247)
	NO: 1068)
368_C08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1248)
	NO: 1069)
368_E12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1249)
	NO: 1070)
368_F09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1250)
	NO: 1071)
368_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1251)
	NO: 1072)
368_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVANINYNGGYKSYADSV	KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1252)
	NO: 1073)
369_A07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1253)
	NO: 1074)
369_B05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1254)
	NO: 1075)
369_C05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYATTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1255)
	NO: 1076)
369_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1256)
	NO: 1077)
369_D07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1257)
	NO: 1078)
369_D09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1258)
	NO: 1079)
369_E06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1259)
	NO: 1080)
369_F08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1260)
	NO: 1081)
369_G08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYKGYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1261)
	NO: 1082)
370_A02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1262)
	NO: 1083)
370_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVANINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1263)
	NO: 1084)
370_B11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQGYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1264)
	NO: 1085)
370_B12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV	KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1265)
	NO: 1086)
370_D01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1266)
	NO: 1087)
370_D05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYKGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1267)
	NO: 1088)
370_F03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMNWVRQAPGKGLEWVSSINYNSGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1268)
	NO: 1089)
370_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1269)
	NO: 1090)
370_H07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1270)
	NO: 1091)
371_A10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1271)
	NO: 1092)
371_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1272)
	NO: 1093)
371_B04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1273)
	NO: 1094)
371_B09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYTGYADSV	KPGKAPKLVIYATTSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1274)
	NO: 1095)
371_B12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1275)
	NO: 1096)
371_C01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMHWVRQAPGKGLEWVSSINYNGGYTGYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1276)
	NO: 1097)
371_C04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYKGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1277)
	NO: 1098)
371_C05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMHWVRQAPGKGLEWVANINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1278)
	NO: 1099)
371_C12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1279)
	NO: 1100)
371_D02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1280)
	NO: 1101)
371_D04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1281)
	NO: 1102)
371_E06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAVTSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1282)
	NO: 1103)
371_E07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1283)
	NO: 1104)
371_E10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1284)
	NO: 1105)
371_F10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1285)
	NO: 1106)
371_F11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1286)
	NO: 1107)
371_G02	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1287)
	NO: 1108)
371_G04	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLLIYAATSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1288)
	NO: 1109)
371_G09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVANINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1289)
	NO: 1110)
371_G11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMNWVRQAPGKGLEWVSNINYNSGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1290)
	NO: 1111)
371_H04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1291)
	NO: 1112)
371_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1292)
	NO: 1113)
371_H06	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1293)
	NO: 1114)
371_H08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ
	GMNWVRQAPGKGLEWVASINYNGGYKGYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1294)
	NO: 1115)
371_H10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1295)
	NO: 1116)
372_B02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAVTSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1296)
	NO: 1117)
372_C06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1297)
	NO: 1118)
372_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV	KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1298)
	NO: 1119)
372_E01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1299)
	NO: 1120)
372_G12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1300)
	NO: 1121)
373_A01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLVIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1301)
	NO: 1122)
373_A03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVANINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1302)
	NO: 1123)
373_A05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1303)
	NO: 1124)
373_A09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1304)
	NO: 1125)
373_A11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSNY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVANINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1305)
	NO: 1126)
373_A12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1306)
	NO: 1127)
373_B05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1307)
	NO: 1128)
373_B07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1308)
	NO: 1129)
373_C03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1309)
	NO: 1130)
373_C07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1310)
	NO: 1131)
373_C10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1311)
	NO: 1132)
373_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1312)
	NO: 1133)
373_D12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYKGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1313)
	NO: 1134)
373_E10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1314)
	NO: 1135)
373_F08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1315)
	NO: 1136)
373_F11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMHWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNLPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1316)
	NO: 1137)
373_F12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1317)
	NO: 1138)
373_G08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1318)
	NO: 1139)
373_H03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLLIYATTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1319)
	NO: 1140)
373_H07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1320)
	NO: 1141)
373_H09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLNWYQQ
	GMNWVRQAPGKGLEWVASINYNSGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1321)
	NO: 1142)
374_A06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1322)
	NO: 1143)
374_A09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSSINYNGGYKGYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1323)
	NO: 1144)
374_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1324)
	NO: 1145)
374_B05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1325)
	NO: 1146)
374_B08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1326)
	NO: 1147)
374_B10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYTSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1327)
	NO: 1148)
374_C01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1328)
	NO: 1149)
374_C09	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	GMNWVRQAPGKGLEWVSSINYNGGYKGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1329)
	NO: 1150)
374_C12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1330)
	NO: 1151)
374_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1331)
	NO: 1152)
374_D05	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1332)
	NO: 1153)
374_D06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1333)
	NO: 1154)
374_D07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1334)
	NO: 1155)
374_D10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMHWVRQAPGKGLEWVASINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1335)
	NO: 1156)
374_E10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1336)
	NO: 1157)
374_E12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1337)
	NO: 1158)
374_F06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1338)
	NO: 1159)
374_F07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVASINYNGGYTGYADSV	KPGKAPKLVIYAVTSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1339)
	NO: 1160)
374_F08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1340)
	NO: 1161)
374_G03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1341)
	NO: 1162)
374_G08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1342)
	NO: 1163)
374_G09	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1343)
	NO: 1164)
374_G10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYTSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1344)
	NO: 1165)
374_G11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1345)
	NO: 1166)
374_H01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYENPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1346)
	NO: 1167)
374_H11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSLHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1347)
	NO: 1168)
375_A01	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1348)
	NO: 1169)
375_A07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSSINYNSGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1349)
	NO: 1170)
375_A08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1350)
	NO: 1171)
375_A12	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNSGYKSYADSV	KPGKAPKLVIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1351)
	NO: 1172)
375_B12	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1352)
	NO: 1173)
375_C04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1353)
	NO: 1174)
375_D01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1354)
	NO: 1175)
375_D10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1355)
	NO: 1176)
375_E02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1356)
	NO: 1177)
375_E03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVANINYNGGYTGYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1357)
	NO: 1178)
375_E05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1358)
	NO: 1179)
375_E06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYKSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1359)
	NO: 1180)
375_E10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1360)
	NO: 1181)
375_F02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVASINYNSGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1361)
	NO: 1182)
375_F07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1362)
	NO: 1183)
375_F08	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	GMNWVRQAPGKGLEWVSSINYNSGYKSYADSV	KPGKAPKLLIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1363)
	NO: 1184)
375_G04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMNWVRQAPGKGLEWVASINYNSGYTGYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1364)
	NO: 1185)
375_G05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAVTSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID No: 1365)
	NO: 1186)
375_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1366)
	NO: 1187)
375_H07	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1367)
	NO: 1188)
376_A03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1368)
	NO: 1189)
376_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYKSYADSV	KPGKAPKLVIYAVTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDSPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1369)
	NO: 1190)
376_B10	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLVIYAATSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1370)
	NO: 1191)
376_C04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLLIYAVTSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDNPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1371)
	NO: 1192)
376_C08	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNSGYTGYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1372)
	NO: 1193)
376_D07	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1373)
	NO: 1194)
376_E02	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLVIYAATSRHSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSDNTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1374)
	NO: 1195)
376_E11	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVSGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYELPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1375)
	NO: 1196)
376_F01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKSYADSV	KPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1376)
	NO: 1197)
376_F06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	GMNWVRQAPGKGLEWVSGINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYETPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1377)
	NO: 1198)
376_G05	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1378)
	NO: 1199)
376_G06	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYNSPLTFGGGTKVEIK (SEQ
	ARGANWHDTHLDYWGQGTLVTVSS (SEQ ID	ID NO: 1379)
	NO: 1200)
376_G10	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVNWYQQ
	GMNWVRQAPGKGLEWVAGINYNGGYTSYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1380)
	NO: 1201)
376_H01	EVQLLESGGGLVQPGGSLRLSCAASGFTFSDY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLLIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYSTPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1381)
	NO: 1202)
376_H04	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSY	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVNWYQQ
	SMNWVRQAPGKGLEWVAGINYNGGYKGYADSV	KPGKAPKLVIYAATSRASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYDLPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1382)
	NO: 1203)
376_H11	EVQLLESGGGLVQPGGSLRLSCAASGFTFDSY	DIQMTQSPSSLSASVGDRVTITCRASQSISRYLNWYQQ
	SMNWVRQAPGKGLEWVSNINYNGGYTGYADSV	KPGKAPKLLIYAVTSLASGVPSRFSGSGSGTDFTLTIS
	KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYC	SLQPEDFATYYCQQSYESPLTFGGGTKVEIK (SEQ
	ARGANWHDTALDYWGQGTLVTVSS (SEQ ID	ID NO: 1383)
	NO: 1204)

Table 3C provides the amino acid sequences of the CDRs of the antibodies shown in Table 2C.

TABLE 3C
CDR sequences for Group III antibodies
Ab	HCDR1	HCDR2	HCDR3	LCDR1	LCDR2	LCDR3
365_C05	SDYSMN	WVSGINYNGGYKG	ARGANWHDTHLD	LTYLNWY	LLIYAATSRH	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5643)	(SEQ ID NO: 5822)	(SEQ ID NO: 6001)	(SEQ ID NO: 6180)	(SEQ ID NO: 6359)
	NO: 5464)
365_E10	DSYSMN	WVSSINYNSGYKG	ARGANWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5644)	(SEQ ID NO: 5823)	(SEQ ID NO: 6002)	(SEQ ID NO: 6181)	(SEQ ID NO: 6360)
	NO: 5465)
365_E12	SDYGMN	WVSNINYNGGYTG	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5645)	(SEQ ID NO: 5824)	(SEQ ID NO: 6003)	(SEQ ID NO: 6182)	(SEQ ID NO: 6361)
	NO: 5466)
365_F02	SSYSMN	WVSGINYNGGYKG	ARGANWHDTHLD	LTYVNWY	LLIYAATSRH	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5646)	(SEQ ID NO: 5825)	(SEQ ID NO: 6004)	(SEQ ID NO: 6183)	(SEQ ID NO: 6362)
	NO: 5467)
365_F03	DSYSMN	WVSSINYNGGYTS	ARGANWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5647)	(SEQ ID NO: 5826)	(SEQ ID NO: 6005)	(SEQ ID NO: 6184)	(SEQ ID NO: 6363)
	NO: 5468)
365_G03	SSYGMN	WVAGINYNSGYKG	ARGANWHDTHLD	VSYLNWY	LLIYAATSRA	QQSYNTPL
	(SEQ ID	(SEQ ID NO: 5648)	(SEQ ID NO: 5827)	(SEQ ID NO: 6006)	(SEQ ID NO: 6185)	(SEQ ID NO: 6364)
	NO: 5469)
365_G04	DSYSMN	WVAGINYNGGYTG	ARGANWHDTHLD	VSYVNWY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5649)	(SEQ ID NO: 5828)	(SEQ ID NO: 6007)	(SEQ ID NO: 6186)	(SEQ ID NO: 6365)
	NO: 5470)
365_G05	SSYGMN	WVSGINYNGGYKG	ARGANWHDTALD	LSYLNWY	LVIYAATSLA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5650)	(SEQ ID NO: 5829)	(SEQ ID NO: 6008)	(SEQ ID NO: 6187)	(SEQ ID NO: 6366)
	NO: 5471)
365_G09	SSYSMN	WVSGINYNGGYKS	ARGANWHDTHLD	ITYLNWY	LVIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5651)	(SEQ ID NO: 5830)	(SEQ ID NO: 6009)	(SEQ ID NO: 6188)	(SEQ ID NO: 6367)
	NO: 5472)
365_H07	DSYSMN	WVSGINYNGGYTS	ARGANWHDTHLD	STYVNWY	LLIYAATSRH	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5652)	(SEQ ID NO: 5831)	(SEQ ID NO: 6010)	(SEQ ID NO: 6189)	(SEQ ID NO: 6368)
	NO: 5473)
366_A06	SDYSMN	WVASINYNGGYKS	ARGANWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5653)	(SEQ ID NO: 5832)	(SEQ ID NO: 6011)	(SEQ ID NO: 6190)	(SEQ ID NO: 6369)
	NO: 5474)
366_A08	DDYSMN	WVSGINYNSGYKG	ARGANWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5654)	(SEQ ID NO: 5833)	(SEQ ID NO: 6012)	(SEQ ID NO: 6191)	(SEQ ID NO: 6370)
	NO: 5475)
366_B05	SDYSMN	WVSGINYNSGYKS	ARGANWHDTALD	SSYLNWY	LVIYAVTSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5655)	(SEQ ID NO: 5834)	(SEQ ID NO: 6013)	(SEQ ID NO: 6192)	(SEQ ID NO: 6371)
	NO: 5476)
366_B07	SDYGMN	WVSGINYNGGYTS	ARGANWHDTHLD	VSYLNWY	LVIYATTSRA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5656)	(SEQ ID NO: 5835)	(SEQ ID NO: 6014)	(SEQ ID NO: 6193)	(SEQ ID NO: 6372)
	NO: 5477)
366_E01	DSYGMN	WVSNINYNGGYKS	ARGANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 5657)	(SEQ ID NO: 5836)	(SEQ ID NO: 6015)	(SEQ ID NO: 6194)	(SEQ ID NO: 6373)
	NO: 5478)
366_E08	SDYSMN	WVSNINYNGGYTS	ARGANWHDTHLD	VTYLNWY	LLIYAATSRH	QQSYSNPL
	(SEQ ID	(SEQ ID NO: 5658)	(SEQ ID NO: 5837)	(SEQ ID NO: 6016)	(SEQ ID NO: 6195)	(SEQ ID NO: 6374)
	NO: 5479)
366_F02	SSYGMN	WVSGINYNSGYTG	ARGANWHDTHLD	LTYLNWY	LVIYAATSRH	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5659)	(SEQ ID NO: 5838)	(SEQ ID NO: 6017)	(SEQ ID NO: 6196)	(SEQ ID NO: 6375)
	NO: 5480)
366_G12	SSYGMH	WVSGINYNSGYKG	ARGANWHDTHLD	LSYLNWY	LLIYAATSRH	QQSYNTPL
	(SEQ ID	(SEQ ID NO: 5660)	(SEQ ID NO: 5839)	(SEQ ID NO: 6018)	(SEQ ID NO: 6197)	(SEQ ID NO: 6376)
	NO: 5481)
366_H04	DSYGMN	WVSNINYNGGYKS	ARGANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 5661)	(SEQ ID NO: 5840)	(SEQ ID NO: 6019)	(SEQ ID NO: 6198)	(SEQ ID NO: 6377)
	NO: 5482)
367_A03	DSYGMN	WVAGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LLIYATTSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5662)	(SEQ ID NO: 5841)	(SEQ ID NO: 6020)	(SEQ ID NO: 6199)	(SEQ ID NO: 6378)
	NO: 5483)
367_A06	DSYGMN	WVASINYNGGYKG	ARGANWHDTHLD	LSYVNWY	LLIYAATSRH	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5663)	(SEQ ID NO: 5842)	(SEQ ID NO: 6021)	(SEQ ID NO: 6200)	(SEQ ID NO: 6379)
	NO: 5484)
367_A08	DSYGMN	WVAGINYNGGYTS	ARGANWHDTHLD	LTYLNWY	LLIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5664)	(SEQ ID NO: 5843)	(SEQ ID NO: 6022)	(SEQ ID NO: 6201)	(SEQ ID NO: 6380)
	NO: 5485)
367_A10	SSYGMN	WVAGINYNSGYTS	ARGANWHDTHLD	ITYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5665)	(SEQ ID NO: 5844)	(SEQ ID NO: 6023)	(SEQ ID NO: 6202)	(SEQ ID NO: 6381)
	NO: 5486)
367_A12	SSYGMN	WVSGINYNSGYTS	ARGANWHDTHLD	LSYLNWY	LLIYAATSLH	QQSYNNPL
	(SEQ ID	(SEQ ID NO: 5666)	(SEQ ID NO: 5845)	(SEQ ID NO: 6024)	(SEQ ID NO: 6203)	(SEQ ID NO: 6382)
	NO: 5487)
367_B01	SSYSMN	WVAGINYNGGYKG	ARGANWHDTALD	SSYVNWY	LVIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5667)	(SEQ ID NO: 5846)	(SEQ ID NO: 6025)	(SEQ ID NO: 6204)	(SEQ ID NO: 6383)
	NO: 5488)
367_B04	DSYSMN	WVSGINYNSGYKS	ARGANWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5668)	(SEQ ID NO: 5847)	(SEQ ID NO: 6026)	(SEQ ID NO: 6205)	(SEQ ID NO: 6384)
	NO: 5489)
367_B12	SSYGMH	WVASINYNGGYKS	ARGANWHDTHLD	LSYVNWY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5669)	(SEQ ID NO: 5848)	(SEQ ID NO: 6027)	(SEQ ID NO: 6206)	(SEQ ID NO: 6385)
	NO: 5490)
367_C07	SSYSMN	WVSSINYNSGYTG	ARGANWHDTHLD	LTYVNWY	LLIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID NO: 5670)	(SEQ ID NO: 5849)	(SEQ ID NO: 6028)	(SEQ ID NO: 6207)	(SEQ ID NO: 6386)
	NO: 5491)
367_C10	DSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	VSYVNWY	LLIYAVTSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5671)	(SEQ ID NO: 5850)	(SEQ ID NO: 6029)	(SEQ ID NO: 6208)	(SEQ ID NO: 6387)
	NO: 5492)
367_D03	DSYSMN	WVSSINYNGGYTG	ARGANWHDTHLD	ITYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5672)	(SEQ ID NO: 5851)	(SEQ ID NO: 6030)	(SEQ ID NO: 6209)	(SEQ ID NO: 6388)
	NO: 5493)
367_D06	DSYSMN	WVAGINYNGGYTS	ARGANWHDTHLD	STYLNWY	LVIYAATSLA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5673)	(SEQ ID NO: 5852)	(SEQ ID NO: 6031)	(SEQ ID NO: 6210)	(SEQ ID NO: 6389)
	NO: 5494)
367_D08	SDYSMN	WVAGINYNGGYTS	ARGANWHDTHLD	LSYLNWY	LVIYAATSRH	QQSDDLPL
	(SEQ ID	(SEQ ID NO: 5674)	(SEQ ID NO: 5853)	(SEQ ID NO: 6032)	(SEQ ID NO: 6211)	(SEQ ID NO: 6390)
	NO: 5495)
367_D12	SSYSMN	WVSSINYNGGYTG	ARGANWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5675)	(SEQ ID NO: 5854)	(SEQ ID NO: 6033)	(SEQ ID NO: 6212)	(SEQ ID NO: 6391)
	NO: 5496)
367_E05	SSYGMN	WVAGINYNGGYTS	ARGANWHDTHLD	LSYLNWY	LLIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5676)	(SEQ ID NO: 5855)	(SEQ ID NO: 6034)	(SEQ ID NO: 6213)	(SEQ ID NO: 6392)
	NO: 5497)
367_F01	DSYSMN	WVSNINYNGGYKS	ARGANWHDTHLD	ISYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5677)	(SEQ ID NO: 5856)	(SEQ ID NO: 6035)	(SEQ ID NO: 6214)	(SEQ ID NO: 6393)
	NO: 5498)
367_G01	DSYGMN	WVASINYNSGYTG	ARGANWHDTHLD	SSYLNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5678)	(SEQ ID NO: 5857)	(SEQ ID NO: 6036)	(SEQ ID NO: 6215)	(SEQ ID NO: 6394)
	NO: 5499)
367_G04	SSYSMN	WVAGINYNSGYTS	ARGANWHDTHLD	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5679)	(SEQ ID NO: 5858)	(SEQ ID NO: 6037)	(SEQ ID NO: 6216)	(SEQ ID NO: 6395)
	NO: 5500)
367_H02	DSYGMN	WVSSINYNGGYTG	ARGANWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5680)	(SEQ ID NO: 5859)	(SEQ ID NO: 6038)	(SEQ ID NO: 6217)	(SEQ ID NO: 6396)
	NO: 5501)
367_H03	SSYGMN	WVAGINYNSGYTS	ARGANWHDTHLD	ITYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5681)	(SEQ ID NO: 5860)	(SEQ ID NO: 6039)	(SEQ ID NO: 6218)	(SEQ ID NO: 6397)
	NO: 5502)
368_A03	SSYSMN	WVSGINYNGGYTG	ARGANWHDTHLD	ISYLNWY	LLIYAVTSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5682)	(SEQ ID NO: 5861)	(SEQ ID NO: 6040)	(SEQ ID NO: 6219)	(SEQ ID NO: 6398)
	NO: 5503)
368_A04	DDYSMN	WVAGINYNGGYKS	ARGANWHDTHLD	LTYLNWY	LVIYAVTSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5683)	(SEQ ID NO: 5862)	(SEQ ID NO: 6041)	(SEQ ID NO: 6220)	(SEQ ID NO: 6399)
	NO: 5504)
368_B09	DSYGMN	WVSNINYNGGYKG	ARGANWHDTHLD	LSYLNWY	LLIYAATSRH	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5684)	(SEQ ID NO: 5863)	(SEQ ID NO: 6042)	(SEQ ID NO: 6221)	(SEQ ID NO: 6400)
	NO: 5505)
368_C02	DDYSMN	WVANINYNGGYKG	ARGANWHDTHLD	STYVNWY	LLIYAATSLA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5685)	(SEQ ID NO: 5864)	(SEQ ID NO: 6043)	(SEQ ID NO: 6222)	(SEQ ID NO: 6401)
	NO: 5506)
368_C08	SDYSMN	WVSGINYNGGYTS	ARGANWHDTHLD	LTYVNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5686)	(SEQ ID NO: 5865)	(SEQ ID NO: 6044)	(SEQ ID NO: 6223)	(SEQ ID NO: 6402)
	NO: 5507)
368_E12	SDYGMN	WVAGINYNGGYTS	ARGANWHDTHLD	VSYVNWY	LVIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5687)	(SEQ ID NO: 5866)	(SEQ ID NO: 6045)	(SEQ ID NO: 6224)	(SEQ ID NO: 6403)
	NO: 5508)
368_F09	SSYGMN	WVSGINYNSGYTS	ARGANWHDTHLD	LTYLNWY	LLIYAASSLQ	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5688)	(SEQ ID NO: 5867)	(SEQ ID NO: 6046)	(SEQ ID NO: 6225)	(SEQ ID NO: 6404)
	NO: 5509)
368_H02	SSYGMN	WVAGINYNSGYTS	ARGANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5689)	(SEQ ID NO: 5868)	(SEQ ID NO: 6047)	(SEQ ID NO: 6226)	(SEQ ID NO: 6405)
	NO: 5510)
368_H05	SSYSMN	WVANINYNGGYKS	ARGANWHDTHLD	VSYVNWY	LVIYATTSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5690)	(SEQ ID NO: 5869)	(SEQ ID NO: 6048)	(SEQ ID NO: 6227)	(SEQ ID NO: 6406)
	NO: 5511)
369_A07	SSYSMN	WVAGINYNGGYKG	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5691)	(SEQ ID NO: 5870)	(SEQ ID NO: 6049)	(SEQ ID NO: 6228)	(SEQ ID NO: 6407)
	NO: 5512)
369_B05	DSYSMN	WVSGINYNGGYKS	ARGANWHDTHLD	ISYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5692)	(SEQ ID NO: 5871)	(SEQ ID NO: 6050)	(SEQ ID NO: 6229)	(SEQ ID NO: 6408)
	NO: 5513)
369_C05	DSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	SSYVNWY	LVIYATTSRH	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5693)	(SEQ ID NO: 5872)	(SEQ ID NO: 6051)	(SEQ ID NO: 6230)	(SEQ ID NO: 6409)
	NO: 5514)
369_D03	SSYSMN	WVSGINYNGGYTS	ARGANWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5694)	(SEQ ID NO: 5873)	(SEQ ID NO: 6052)	(SEQ ID NO: 6231)	(SEQ ID NO: 6410)
	NO: 5515)
369_D07	SSYGMN	WVSGINYNGGYKS	ARGANWHDTHLD	VSYLNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5695)	(SEQ ID NO: 5874)	(SEQ ID NO: 6053)	(SEQ ID NO: 6232)	(SEQ ID NO: 6411)
	NO: 5516)
369_D09	SDYGMN	WVSNINYNGGYTS	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5696)	(SEQ ID NO: 5875)	(SEQ ID NO: 6054)	(SEQ ID NO: 6233)	(SEQ ID NO: 6412)
	NO: 5517)
369_E06	SSYGMN	WVSGINYNGGYTS	ARGANWHDTALD	ISYLNWY	LVIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5697)	(SEQ ID NO: 5876)	(SEQ ID NO: 6055)	(SEQ ID NO: 6234)	(SEQ ID NO: 6413)
	NO: 5518)
369_F08	SDYGMH	WVSGINYNSGYTS	ARGANWHDTALD	LSYLNWY	LLIYAASSLQ	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5698)	(SEQ ID NO: 5877)	(SEQ ID NO: 6056)	(SEQ ID NO: 6235)	(SEQ ID NO: 6414)
	NO: 5519)
369_G08	DSYSMN	WVSSINYNGGYKG	ARGANWHDTHLD	LTYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5699)	(SEQ ID NO: 5878)	(SEQ ID NO: 6057)	(SEQ ID NO: 6236)	(SEQ ID NO: 6415)
	NO: 5520)
370_A02	DSYGMN	WVAGINYNGGYTG	ARGANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5700)	(SEQ ID NO: 5879)	(SEQ ID NO: 6058)	(SEQ ID NO: 6237)	(SEQ ID NO: 6416)
	NO: 5521)
370_B03	SSYSMN	WVANINYNGGYTG	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYNNPL
	(SEQ ID	(SEQ ID NO: 5701)	(SEQ ID NO: 5880)	(SEQ ID NO: 6059)	(SEQ ID NO: 6238)	(SEQ ID NO: 6417)
	NO: 5522)
370_B11	DSYSMN	WVSGINYNSGYTS	ARGANWHDTHLD	LSYLNWY	LVIYAATSRH	QQGYDLPL
	(SEQ ID	(SEQ ID NO: 5702)	(SEQ ID NO: 5881)	(SEQ ID NO: 6060)	(SEQ ID NO: 6239)	(SEQ ID NO: 6418)
	NO: 5523)
370_B12	SDYSMN	WVSGINYNGGYKG	ARGANWHDTALD	LSYVNWY	LVIYATTSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5703)	(SEQ ID NO: 5882)	(SEQ ID NO: 6061)	(SEQ ID NO: 6240)	(SEQ ID NO: 6419)
	NO: 5524)
370_D01	SSYSMN	WVSSINYNGGYTG	ARGANWHDTALD	LSYLNWY	LLIYAATSRH	QQSYNTPL
	(SEQ ID	(SEQ ID NO: 5704)	(SEQ ID NO: 5883)	(SEQ ID NO: 6062)	(SEQ ID NO: 6241)	(SEQ ID NO: 6420)
	NO: 5525)
370_D05	DDYSMN	WVSNINYNGGYKG	ARGANWHDTALD	ITYLNWY	LVIYAATSRH	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5705)	(SEQ ID NO: 5884)	(SEQ ID NO: 6063)	(SEQ ID NO: 6242)	(SEQ ID NO: 6421)
	NO: 5526)
370_F03	SSYGMN	WVSSINYNSGYKS	ARGANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5706)	(SEQ ID NO: 5885)	(SEQ ID NO: 6064)	(SEQ ID NO: 6243)	(SEQ ID NO: 6422)
	NO: 5527)
370_H02	DSYSMN	WVSGINYNSGYTS	ARGANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5707)	(SEQ ID NO: 5886)	(SEQ ID NO: 6065)	(SEQ ID NO: 6244)	(SEQ ID NO: 6423)
	NO: 5528)
370_H07	SSYSMN	WVAGINYNGGYKS	ARGANWHDTALD	LSYLNWY	LLIYAATSLA	QQSDSSPL
	(SEQ ID	(SEQ ID NO: 5708)	(SEQ ID NO: 5887)	(SEQ ID NO: 6066)	(SEQ ID NO: 6245)	(SEQ ID NO: 6424)
	NO: 5529)
371_A10	DDYSMN	WVSGINYNGGYKG	ARGANWHDTALD	VSYLNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5709)	(SEQ ID NO: 5888)	(SEQ ID NO: 6067)	(SEQ ID NO: 6246)	(SEQ ID NO: 6425)
	NO: 5530)
371_B03	SSYGMH	WVASINYNGGYTS	ARGANWHDTHLD	LSYVNWY	LLIYATTSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5710)	(SEQ ID NO: 5889)	(SEQ ID NO: 6068)	(SEQ ID NO: 6247)	(SEQ ID NO: 6426)
	NO: 5531)
371_B04	SSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	LSYLNWY	LVIYAVTSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5711)	(SEQ ID NO: 5890)	(SEQ ID NO: 6069)	(SEQ ID NO: 6248)	(SEQ ID NO: 6427)
	NO: 5532)
371_B09	SSYSMN	WVAGINYNSGYTG	ARGANWHDTHLD	LSYVNWY	LVIYATTSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5712)	(SEQ ID NO: 5891)	(SEQ ID NO: 6070)	(SEQ ID NO: 6249)	(SEQ ID NO: 6428)
	NO: 5533)
371_B12	SDYSMN	WVAGINYNSGYTS	ARGANWHDTALD	VTYLNWY	LVIYAATSRH	QQSYNNPL
	(SEQ ID	(SEQ ID NO: 5713)	(SEQ ID NO: 5892)	(SEQ ID NO: 6071)	(SEQ ID NO: 6250)	(SEQ ID NO: 6429)
	NO: 5534)
371_C01	SSYGMH	WVSSINYNGGYTG	ARGANWHDTHLD	VSYLNWY	LLIYAATSRH	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5714)	(SEQ ID NO: 5893)	(SEQ ID NO: 6072)	(SEQ ID NO: 6251)	(SEQ ID NO: 6430)
	NO: 5535)
371_C04	DSYGMN	WVSGINYNSGYKG	ARGANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5715)	(SEQ ID NO: 5894)	(SEQ ID NO: 6073)	(SEQ ID NO: 6252)	(SEQ ID NO: 6431)
	NO: 5536)
371_C05	SDYGMH	WVANINYNGGYTG	ARGANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5716)	(SEQ ID NO: 5895)	(SEQ ID NO: 6074)	(SEQ ID NO: 6253)	(SEQ ID NO: 6432)
	NO: 5537)
371_C12	SSYSMN	WVAGINYNSGYKS	ARGANWHDTHLD	VSYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5717)	(SEQ ID NO: 5896)	(SEQ ID NO: 6075)	(SEQ ID NO: 6254)	(SEQ ID NO: 6433)
	NO: 5538)
371_D02	DDYSMN	WVAGINYNGGYKS	ARGANWHDTALD	VTYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5718)	(SEQ ID NO: 5897)	(SEQ ID NO: 6076)	(SEQ ID NO: 6255)	(SEQ ID NO: 6434)
	NO: 5539)
371_D04	DDYSMN	WVAGINYNGGYTG	ARGANWHDTHLD	VSYVNWY	LLIYAATSLA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5719)	(SEQ ID NO: 5898)	(SEQ ID NO: 6077)	(SEQ ID NO: 6256)	(SEQ ID NO: 6435)
	NO: 5540)
371_E06	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	STYLNWY	LLIYAVTSLH	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5720)	(SEQ ID NO: 5899)	(SEQ ID NO: 6078)	(SEQ ID NO: 6257)	(SEQ ID NO: 6436)
	NO: 5541)
371_E07	DSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	ISYLNWY	LLIYAATSLA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5721)	(SEQ ID NO: 5900)	(SEQ ID NO: 6079)	(SEQ ID NO: 6258)	(SEQ ID NO: 6437)
	NO: 5542)
371_E10	DSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	STYLNWY	LLIYAVTSRA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5722)	(SEQ ID NO: 5901)	(SEQ ID NO: 6080)	(SEQ ID NO: 6259)	(SEQ ID NO: 6438)
	NO: 5543)
371_F10	DSYGMN	WVSGINYNSGYTS	ARGANWHDTALD	SSYLNWY	LVIYAVTSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5723)	(SEQ ID NO: 5902)	(SEQ ID NO: 6081)	(SEQ ID NO: 6260)	(SEQ ID NO: 6439)
	NO: 5544)
371_F11	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	ISYVNWY	LLIYAVTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5724)	(SEQ ID NO: 5903)	(SEQ ID NO: 6082)	(SEQ ID NO: 6261)	(SEQ ID NO: 6440)
	NO: 5545)
371_G02	DSYGMN	WVASINYNGGYTS	ARGANWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5725)	(SEQ ID NO: 5904)	(SEQ ID NO: 6083)	(SEQ ID NO: 6262)	(SEQ ID NO: 6441)
	NO: 5546)
371_G04	DSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	LSYLNWY	LLIYAATSLH	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5726)	(SEQ ID NO: 5905)	(SEQ ID NO: 6084)	(SEQ ID NO: 6263)	(SEQ ID NO: 6442)
	NO: 5547)
371_G09	SSYSMN	WVANINYNGGYTG	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSDSTPL
	(SEQ ID	(SEQ ID NO: 5727)	(SEQ ID NO: 5906)	(SEQ ID NO: 6085)	(SEQ ID NO: 6264)	(SEQ ID NO: 6443)
	NO: 5548)
371_G11	SSYGMN	WVSNINYNSGYTS	ARGANWHDTALD	LSYVNWY	LLIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5728)	(SEQ ID NO: 5907)	(SEQ ID NO: 6086)	(SEQ ID NO: 6265)	(SEQ ID NO: 6444)
	NO: 5549)
371_H04	SSYGMN	WVSNINYNGGYTG	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5729)	(SEQ ID NO: 5908)	(SEQ ID NO: 6087)	(SEQ ID NO: 6266)	(SEQ ID NO: 6445)
	NO: 5550)
371_H05	SSYGMN	WVSGINYNSGYKS	ARGANWHDTALD	ISYLNWY	LLIYAATSLA	QQSYSLPL
	(SEQ ID	(SEQ ID NO: 5730)	(SEQ ID NO: 5909)	(SEQ ID NO: 6088)	(SEQ ID NO: 6267)	(SEQ ID NO: 6446)
	NO: 5551)
371_H06	DSYGMN	WVSGINYNGGYTS	ARGANWHDTALD	SSYLNWY	LVIYAVTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5731)	(SEQ ID NO: 5910)	(SEQ ID NO: 6089)	(SEQ ID NO: 6268)	(SEQ ID NO: 6447)
	NO: 5552)
371_H08	SSYGMN	WVASINYNGGYKG	ARGANWHDTHLD	ISYVNWY	LVIYAVTSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5732)	(SEQ ID NO: 5911)	(SEQ ID NO: 6090)	(SEQ ID NO: 6269)	(SEQ ID NO: 6448)
	NO: 5553)
371_H10	SSYSMN	WVAGINYNSGYKS	ARGANWHDTHLD	STYLNWY	LLIYAATSRH	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5733)	(SEQ ID NO: 5912)	(SEQ ID NO: 6091)	(SEQ ID NO: 6270)	(SEQ ID NO: 6449)
	NO: 5554)
372_B02	SSYSMN	WVSGINYNSGYTS	ARGANWHDTALD	LSYVNWY	LLIYAVTSLA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5734)	(SEQ ID NO: 5913)	(SEQ ID NO: 6092)	(SEQ ID NO: 6271)	(SEQ ID NO: 6450)
	NO: 5555)
372_C06	SDYSMN	WVSGINYNGGYTS	ARGANWHDTALD	VSYVNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 5735)	(SEQ ID NO: 5914)	(SEQ ID NO: 6093)	(SEQ ID NO: 6272)	(SEQ ID NO: 6451)
	NO: 5556)
372_D03	SSYSMN	WVAGINYNSGYKS	ARGANWHDTALD	LSYVNWY	LVIYAVTSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5736)	(SEQ ID NO: 5915)	(SEQ ID NO: 6094)	(SEQ ID NO: 6273)	(SEQ ID NO: 6452)
	NO: 5557)
372_E01	DDYSMN	WVSGINYNGGYKG	ARGANWHDTALD	VSYLNWY	LVIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5737)	(SEQ ID NO: 5916)	(SEQ ID NO: 6095)	(SEQ ID NO: 6274)	(SEQ ID NO: 6453)
	NO: 5558)
372_G12	DSYSMN	WVAGINYNGGYTG	ARGANWHDTHLD	LTYLNWY	LVIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5738)	(SEQ ID NO: 5917)	(SEQ ID NO: 6096)	(SEQ ID NO: 6275)	(SEQ ID NO: 6454)
	NO: 5559)
373_A01	SSYGMN	WVSNINYNGGYTG	ARGANWHDTHLD	VTYLNWY	LVIYATTSRA	QQSYNLPL
	(SEQ ID	(SEQ ID NO: 5739)	(SEQ ID NO: 5918)	(SEQ ID NO: 6097)	(SEQ ID NO: 6276)	(SEQ ID NO: 6455)
	NO: 5560)
373_A03	SDYSMN	WVANINYNGGYTG	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5740)	(SEQ ID NO: 5919)	(SEQ ID NO: 6098)	(SEQ ID NO: 6277)	(SEQ ID NO: 6456)
	NO: 5561)
373_A05	SDYSMN	WVSGINYNSGYKS	ARGANWHDTHLD	LSYVNWY	LVIYAATSRH	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5741)	(SEQ ID NO: 5920)	(SEQ ID NO: 6099)	(SEQ ID NO: 6278)	(SEQ ID NO: 6457)
	NO: 5562)
373_A09	DSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LTYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5742)	(SEQ ID NO: 5921)	(SEQ ID NO: 6100)	(SEQ ID NO: 6279)	(SEQ ID NO: 6458)
	NO: 5563)
373_A11	SNYGMN	WVANINYNGGYTG	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5743)	(SEQ ID NO: 5922)	(SEQ ID NO: 6101)	(SEQ ID NO: 6280)	(SEQ ID NO: 6459)
	NO: 5564)
373_A12	SSYSMN	WVSSINYNGGYTS	ARGANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5744)	(SEQ ID NO: 5923)	(SEQ ID NO: 6102)	(SEQ ID NO: 6281)	(SEQ ID NO: 6460)
	NO: 5565)
373_B05	SDYSMN	WVSNINYNGGYKS	ARGANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYSNPL
	(SEQ ID	(SEQ ID NO: 5745)	(SEQ ID NO: 5924)	(SEQ ID NO: 6103)	(SEQ ID NO: 6282)	(SEQ ID NO: 6461)
	NO: 5566)
373_B07	DSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5746)	(SEQ ID NO: 5925)	(SEQ ID NO: 6104)	(SEQ ID NO: 6283)	(SEQ ID NO: 6462)
	NO: 5567)
373_C03	SSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5747)	(SEQ ID NO: 5926)	(SEQ ID NO: 6105)	(SEQ ID NO: 6284)	(SEQ ID NO: 6463)
	NO: 5568)
373_C07	DSYSMN	WVAGINYNSGYTS	ARGANWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5748)	(SEQ ID NO: 5927)	(SEQ ID NO: 6106)	(SEQ ID NO: 6285)	(SEQ ID NO: 6464)
	NO: 5569)
373_C10	SSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5749)	(SEQ ID NO: 5928)	(SEQ ID NO: 6107)	(SEQ ID NO: 6286)	(SEQ ID NO: 6465)
	NO: 5570)
373_D03	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	VSYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5750)	(SEQ ID NO: 5929)	(SEQ ID NO: 6108)	(SEQ ID NO: 6287)	(SEQ ID NO: 6466)
	NO: 5571)
373_D12	DSYSMN	WVSSINYNSGYKG	ARGANWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYSLPL
	(SEQ ID	(SEQ ID NO: 5751)	(SEQ ID NO: 5930)	(SEQ ID NO: 6109)	(SEQ ID NO: 6288)	(SEQ ID NO: 6467)
	NO: 5572)
373_E10	SDYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LVIYAATSRH	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5752)	(SEQ ID NO: 5931)	(SEQ ID NO: 6110)	(SEQ ID NO: 6289)	(SEQ ID NO: 6468)
	NO: 5573)
373_F08	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5753)	(SEQ ID NO: 5932)	(SEQ ID NO: 6111)	(SEQ ID NO: 6290)	(SEQ ID NO: 6469)
	NO: 5574)
373_F11	DSYGMH	WVSGINYNSGYTS	ARGANWHDTHLD	VSYVNWY	LLIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID NO: 5754)	(SEQ ID NO: 5933)	(SEQ ID NO: 6112)	(SEQ ID NO: 6291)	(SEQ ID NO: 6470)
	NO: 5575)
373_F12	SSYSMN	WVSNINYNGGYTG	ARGANWHDTALD	STYLNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5755)	(SEQ ID NO: 5934)	(SEQ ID NO: 6113)	(SEQ ID NO: 6292)	(SEQ ID NO: 6471)
	NO: 5576)
373_G08	DSYSMN	WVSNINYNGGYTS	ARGANWHDTALD	LTYLNWY	LLIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5756)	(SEQ ID NO: 5935)	(SEQ ID NO: 6114)	(SEQ ID NO: 6293)	(SEQ ID NO: 6472)
	NO: 5577)
373_H03	SSYSMN	WVSGINYNSGYKS	ARGANWHDTALD	LSYLNWY	LLIYATTSRA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5757)	(SEQ ID NO: 5936)	(SEQ ID NO: 6115)	(SEQ ID NO: 6294)	(SEQ ID NO: 6473)
	NO: 5578)
373_H07	SSYSMN	WVAGINYNGGYTS	ARGANWHDTHLD	VTYLNWY	LLIYAASSLQ	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5758)	(SEQ ID NO: 5937)	(SEQ ID NO: 6116)	(SEQ ID NO: 6295)	(SEQ ID NO: 6474)
	NO: 5579)
373_H09	SSYGMN	WVASINYNSGYKS	ARGANWHDTHLD	ITYLNWY	LVIYAATSRA	QQSDDSPL
	(SEQ ID	(SEQ ID NO: 5759)	(SEQ ID NO: 5938)	(SEQ ID NO: 6117)	(SEQ ID NO: 6296)	(SEQ ID NO: 6475)
	NO: 5580)
374_A06	SSYSMN	WVSSINYNSGYTS	ARGANWHDTHLD	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5760)	(SEQ ID NO: 5939)	(SEQ ID NO: 6118)	(SEQ ID NO: 6297)	(SEQ ID NO: 6476)
	NO: 5581)
374_A09	SSYSMN	WVSSINYNGGYKG	ARGANWHDTHLD	LTYVNWY	LLIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5761)	(SEQ ID NO: 5940)	(SEQ ID NO: 6119)	(SEQ ID NO: 6298)	(SEQ ID NO: 6477)
	NO: 5582)
374_B03	DSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5762)	(SEQ ID NO: 5941)	(SEQ ID NO: 6120)	(SEQ ID NO: 6299)	(SEQ ID NO: 6478)
	NO: 5583)
374_B05	DSYSMN	WVSGINYNSGYTS	ARGANWHDTALD	VSYLNWY	LLIYAATSRH	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5763)	(SEQ ID NO: 5942)	(SEQ ID NO: 6121)	(SEQ ID NO: 6300)	(SEQ ID NO: 6479)
	NO: 5584)
374_B08	DSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	VSYVNWY	LLIYAATSRH	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5764)	(SEQ ID NO: 5943)	(SEQ ID NO: 6122)	(SEQ ID NO: 6301)	(SEQ ID NO: 6480)
	NO: 5585)
374_B10	SSYSMN	WVSSINYNSGYTS	ARGANWHDTHLD	LTYVNWY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5765)	(SEQ ID NO: 5944)	(SEQ ID NO: 6123)	(SEQ ID NO: 6302)	(SEQ ID NO: 6481)
	NO: 5586)
374_C01	DSYGMN	WVSGINYNSGYKS	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5766)	(SEQ ID NO: 5945)	(SEQ ID NO: 6124)	(SEQ ID NO: 6303)	(SEQ ID NO: 6482)
	NO: 5587)
374_C09	DSYGMN	WVSSINYNGGYKG	ARGANWHDTHLD	VSYLNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5767)	(SEQ ID NO: 5946)	(SEQ ID NO: 6125)	(SEQ ID NO: 6304)	(SEQ ID NO: 6483)
	NO: 5588)
374_C12	SSYSMN	WVAGINYNGGYKS	ARGANWHDTALD	LTYLNWY	LVIYAATSRA	QQSDNSPL
	(SEQ ID	(SEQ ID NO: 5768)	(SEQ ID NO: 5947)	(SEQ ID NO: 6126)	(SEQ ID NO: 6305)	(SEQ ID NO: 6484)
	NO: 5589)
374_D03	DSYSMN	WVAGINYNGGYKS	ARGANWHDTHLD	VTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5769)	(SEQ ID NO: 5948)	(SEQ ID NO: 6127)	(SEQ ID NO: 6306)	(SEQ ID NO: 6485)
	NO: 5590)
374_D05	DSYSMN	WVSGINYNSGYTG	ARGANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5770)	(SEQ ID NO: 5949)	(SEQ ID NO: 6128)	(SEQ ID NO: 6307)	(SEQ ID NO: 6486)
	NO: 5591)
374_D06	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5771)	(SEQ ID NO: 5950)	(SEQ ID NO: 6129)	(SEQ ID NO: 6308)	(SEQ ID NO: 6487)
	NO: 5592)
374_D07	DSYSMN	WVSGINYNSGYKS	ARGANWHDTALD	VSYLNWY	LVIYAATSLA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5772)	(SEQ ID NO: 5951)	(SEQ ID NO: 6130)	(SEQ ID NO: 6309)	(SEQ ID NO: 6488)
	NO: 5593)
374_D10	SSYGMH	WVASINYNGGYTS	ARGANWHDTHLD	LTYVNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5773)	(SEQ ID NO: 5952)	(SEQ ID NO: 6131)	(SEQ ID NO: 6310)	(SEQ ID NO: 6489)
	NO: 5594)
374_E10	SSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	LSYLNWY	LLIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5774)	(SEQ ID NO: 5953)	(SEQ ID NO: 6132)	(SEQ ID NO: 6311)	(SEQ ID NO: 6490)
	NO: 5595)
374_E12	SSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5775)	(SEQ ID NO: 5954)	(SEQ ID NO: 6133)	(SEQ ID NO: 6312)	(SEQ ID NO: 6491)
	NO: 5596)
374_F06	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	ISYVNWY	LVIYAATSLH	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5776)	(SEQ ID NO: 5955)	(SEQ ID NO: 6134)	(SEQ ID NO: 6313)	(SEQ ID NO: 6492)
	NO: 5597)
374_F07	DSYSMN	WVASINYNGGYTG	ARGANWHDTHLD	LSYLNWY	LVIYAVTSLA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5777)	(SEQ ID NO: 5956)	(SEQ ID NO: 6135)	(SEQ ID NO: 6314)	(SEQ ID NO: 6493)
	NO: 5598)
374_F08	DSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	LTYVNWY	LVIYAVTSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5778)	(SEQ ID NO: 5957)	(SEQ ID NO: 6136)	(SEQ ID NO: 6315)	(SEQ ID NO: 6494)
	NO: 5599)
374_G03	SDYSMN	WVSGINYNGGYTS	ARGANWHDTALD	SSYLNWY	LVIYAATSRA	QQSDDTPL
	(SEQ ID	(SEQ ID NO: 5779)	(SEQ ID NO: 5958)	(SEQ ID NO: 6137)	(SEQ ID NO: 6316)	(SEQ ID NO: 6495)
	NO: 5600)
374_G08	DSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5780)	(SEQ ID NO: 5959)	(SEQ ID NO: 6138)	(SEQ ID NO: 6317)	(SEQ ID NO: 6496)
	NO: 5601)
374_G09	SSYSMN	WVAGINYNGGYKG	ARGANWHDTHLD	VRYLNWY	LVIYAATSLA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5781)	(SEQ ID NO: 5960)	(SEQ ID NO: 6139)	(SEQ ID NO: 6318)	(SEQ ID NO: 6497)
	NO: 5602)
374_G10	SSYSMN	WVSSINYNSGYTS	ARGANWHDTHLD	VSYLNWY	LVIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5782)	(SEQ ID NO: 5961)	(SEQ ID NO: 6140)	(SEQ ID NO: 6319)	(SEQ ID NO: 6498)
	NO: 5603)
374_G11	SDYSMN	WVSGINYNGGYTS	ARGANWHDTALD	ISYVNWY	LVIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5783)	(SEQ ID NO: 5962)	(SEQ ID NO: 6141)	(SEQ ID NO: 6320)	(SEQ ID NO: 6499)
	NO: 5604)
374_H01	DSYSMN	WVAGINYNGGYTS	ARGANWHDTHLD	LSYLNWY	LVIYAATSLA	QQSYENPL
	(SEQ ID	(SEQ ID NO: 5784)	(SEQ ID NO: 5963)	(SEQ ID NO: 6142)	(SEQ ID NO: 6321)	(SEQ ID NO: 6500)
	NO: 5605)
374_H11	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	ISYVNWY	LVIYAATSLH	QQSYSNPL
	(SEQ ID	(SEQ ID NO: 5785)	(SEQ ID NO: 5964)	(SEQ ID NO: 6143)	(SEQ ID NO: 6322)	(SEQ ID NO: 6501)
	NO: 5606)
375_A01	DSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYNTPL
	(SEQ ID	(SEQ ID NO: 5786)	(SEQ ID NO: 5965)	(SEQ ID NO: 6144)	(SEQ ID NO: 6323)	(SEQ ID NO: 6502)
	NO: 5607)
375_A07	DSYSMN	WVSSINYNSGYTG	ARGANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5787)	(SEQ ID NO: 5966)	(SEQ ID NO: 6145)	(SEQ ID NO: 6324)	(SEQ ID NO: 6503)
	NO: 5608)
375_A08	SSYSMN	WVAGINYNGGYTG	ARGANWHDTALD	VTYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5788)	(SEQ ID NO: 5967)	(SEQ ID NO: 6146)	(SEQ ID NO: 6325)	(SEQ ID NO: 6504)
	NO: 5609)
375_A12	SSYSMN	WVSGINYNSGYKS	ARGANWHDTALD	LSYLNWY	LVIYAVTSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5789)	(SEQ ID NO: 5968)	(SEQ ID NO: 6147)	(SEQ ID NO: 6326)	(SEQ ID NO: 6505)
	NO: 5610)
375_B12	DSYSMN	WVAGINYNGGYKS	ARGANWHDTALD	VTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5790)	(SEQ ID NO: 5969)	(SEQ ID NO: 6148)	(SEQ ID NO: 6327)	(SEQ ID NO: 6506)
	NO: 5611)
375_C04	SDYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5791)	(SEQ ID NO: 5970)	(SEQ ID NO: 6149)	(SEQ ID NO: 6328)	(SEQ ID NO: 6507)
	NO: 5612)
375_D01	SSYSMN	WVSGINYNGGYTG	ARGANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5792)	(SEQ ID NO: 5971)	(SEQ ID NO: 6150)	(SEQ ID NO: 6329)	(SEQ ID NO: 6508)
	NO: 5613)
375_D10	SSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LLIYAATSRA	QQSDDSPL
	(SEQ ID	(SEQ ID NO: 5793)	(SEQ ID NO: 5972)	(SEQ ID NO: 6151)	(SEQ ID NO: 6330)	(SEQ ID NO: 6509)
	NO: 5614)
375_E02	SDYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 5794)	(SEQ ID NO: 5973)	(SEQ ID NO: 6152)	(SEQ ID NO: 6331)	(SEQ ID NO: 6510)
	NO: 5615)
375_E03	SDYSMN	WVANINYNGGYTG	ARGANWHDTHLD	LTYLNWY	LVIYAATSLA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5795)	(SEQ ID NO: 5974)	(SEQ ID NO: 6153)	(SEQ ID NO: 6332)	(SEQ ID NO: 6511)
	NO: 5616)
375_E05	SSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LSYLNWY	LVIYAATSLA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 5796)	(SEQ ID NO: 5975)	(SEQ ID NO: 6154)	(SEQ ID NO: 6333)	(SEQ ID NO: 6512)
	NO: 5617)
375_E06	SSYSMN	WVSGINYNGGYKS	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5797)	(SEQ ID NO: 5976)	(SEQ ID NO: 6155)	(SEQ ID NO: 6334)	(SEQ ID NO: 6513)
	NO: 5618)
375_E10	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5798)	(SEQ ID NO: 5977)	(SEQ ID NO: 6156)	(SEQ ID NO: 6335)	(SEQ ID NO: 6514)
	NO: 5619)
375_F02	SSYSMN	WVASINYNSGYTS	ARGANWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5799)	(SEQ ID NO: 5978)	(SEQ ID NO: 6157)	(SEQ ID NO: 6336)	(SEQ ID NO: 6515)
	NO: 5620)
375_F07	SDYSMN	WVSNINYNGGYTG	ARGANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5800)	(SEQ ID NO: 5979)	(SEQ ID NO: 6158)	(SEQ ID NO: 6337)	(SEQ ID NO: 6516)
	NO: 5621)
375_F08	SSYGMN	WVSSINYNSGYKS	ARGANWHDTHLD	LSYLNWY	LLIYAATSRH	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5801)	(SEQ ID NO: 5980)	(SEQ ID NO: 6159)	(SEQ ID NO: 6338)	(SEQ ID NO: 6517)
	NO: 5622)
375_G04	SSYGMN	WVASINYNSGYTG	ARGANWHDTHLD	VSYVNWY	LLIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5802)	(SEQ ID NO: 5981)	(SEQ ID NO: 6160)	(SEQ ID NO: 6339)	(SEQ ID NO: 6518)
	NO: 5623)
375_G05	SSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	VSYLNWY	LLIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5803)	(SEQ ID NO: 5982)	(SEQ ID NO: 6161)	(SEQ ID NO: 6340)	(SEQ ID NO: 6519)
	NO: 5624)
375_H05	SSYSMN	WVSNINYNGGYTG	ARGANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID NO: 5804)	(SEQ ID NO: 5983)	(SEQ ID NO: 6162)	(SEQ ID NO: 6341)	(SEQ ID NO: 6520)
	NO: 5625)
375_H07	SSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	LSYLNWY	LLIYAATSLA	QQSYSSPL
	(SEQ ID	(SEQ ID NO: 5805)	(SEQ ID NO: 5984)	(SEQ ID NO: 6163)	(SEQ ID NO: 6342)	(SEQ ID NO: 6521)
	NO: 5626)
376_A03	SSYGMN	WVAGINYNGGYTG	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5806)	(SEQ ID NO: 5985)	(SEQ ID NO: 6164)	(SEQ ID NO: 6343)	(SEQ ID NO: 6522)
	NO: 5627)
376_B03	SSYSMN	WVAGINYNSGYKS	ARGANWHDTALD	LSYVNWY	LVIYAVTSRH	QQSYDSPL
	(SEQ ID	(SEQ ID NO: 5807)	(SEQ ID NO: 5986)	(SEQ ID NO: 6165)	(SEQ ID NO: 6344)	(SEQ ID NO: 6523)
	NO: 5628)
376_B10	SDYSMN	WVAGINYNGGYKG	ARGANWHDTALD	LSYLNWY	LVIYAATSLA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5808)	(SEQ ID NO: 5987)	(SEQ ID NO: 6166)	(SEQ ID NO: 6345)	(SEQ ID NO: 6524)
	NO: 5629)
376_C04	SSYGMN	WVSNINYNGGYTG	ARGANWHDTALD	LSYVNWY	LLIYAVTSRH	QQSYDNPL
	(SEQ ID	(SEQ ID NO: 5809)	(SEQ ID NO: 5988)	(SEQ ID NO: 6167)	(SEQ ID NO: 6346)	(SEQ ID NO: 6525)
	NO: 5630)
376_C08	DSYSMN	WVAGINYNSGYTG	ARGANWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5810)	(SEQ ID NO: 5989)	(SEQ ID NO: 6168)	(SEQ ID NO: 6347)	(SEQ ID NO: 6526)
	NO: 5631)
376_D07	DSYSMN	WVSGINYNGGYTS	ARGANWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5811)	(SEQ ID NO: 5990)	(SEQ ID NO: 6169)	(SEQ ID NO: 6348)	(SEQ ID NO: 6527)
	NO: 5632)
376_E02	SSYSMN	WVAGINYNGGYKG	ARGANWHDTALD	LSYVNWY	LVIYAATSRH	QQSDNTPL
	(SEQ ID	(SEQ ID NO: 5812)	(SEQ ID NO: 5991)	(SEQ ID NO: 6170)	(SEQ ID NO: 6349)	(SEQ ID NO: 6528)
	NO: 5633)
376_E11	SSYSMN	WVSGINYNGGYTS	ARGANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID NO: 5813)	(SEQ ID NO: 5992)	(SEQ ID NO: 6171)	(SEQ ID NO: 6350)	(SEQ ID NO: 6529)
	NO: 5634)
376_F01	SDYSMN	WVAGINYNGGYKS	ARGANWHDTALD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5814)	(SEQ ID NO: 5993)	(SEQ ID NO: 6172)	(SEQ ID NO: 6351)	(SEQ ID NO: 6530)
	NO: 5635)
376_F06	SSYGMN	WVSGINYNGGYTG	ARGANWHDTHLD	LTYVNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID NO: 5815)	(SEQ ID NO: 5994)	(SEQ ID NO: 6173)	(SEQ ID NO: 6352)	(SEQ ID NO: 6531)
	NO: 5636)
376_G05	SSYSMN	WVAGINYNGGYTS	ARGANWHDTALD	ISYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5816)	(SEQ ID NO: 5995)	(SEQ ID NO: 6174)	(SEQ ID NO: 6353)	(SEQ ID NO: 6532)
	NO: 5637)
376_G06	SSYGMN	WVAGINYNGGYTG	ARGANWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID NO: 5817)	(SEQ ID NO: 5996)	(SEQ ID NO: 6175)	(SEQ ID NO: 6354)	(SEQ ID NO: 6533)
	NO: 5638)
376_G10	DSYGMN	WVAGINYNGGYTS	ARGANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5818)	(SEQ ID NO: 5997)	(SEQ ID NO: 6176)	(SEQ ID NO: 6355)	(SEQ ID NO: 6534)
	NO: 5639)
376_H01	SDYSMN	WVAGINYNGGYKG	ARGANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID NO: 5819)	(SEQ ID NO: 5998)	(SEQ ID NO: 6177)	(SEQ ID NO: 6356)	(SEQ ID NO: 6535)
	NO: 5640)
376_H04	SSYSMN	WVAGINYNGGYKG	ARGANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID NO: 5820)	(SEQ ID NO: 5999)	(SEQ ID NO: 6178)	(SEQ ID NO: 6357)	(SEQ ID NO: 6536)
	NO: 5641)
376_H11	DSYSMN	WVSNINYNGGYTG	ARGANWHDTALD	SRYLNWY	LLIYAVTSLA	QQSYESPL
	(SEQ ID	(SEQ ID NO: 5821)	(SEQ ID NO: 6000)	(SEQ ID NO: 6179)	(SEQ ID NO: 6358)	(SEQ ID NO: 6537)
	NO: 5642)

The consensus sequences for each of these CDRs shown in FIG. 3C are as follows:

HCDR1:
(SEQ ID NO: 6566)
S/DS/DYS/GMN/H
HCDR2:
(SEQ ID NO: 6594)
WVS/AG/S/NINYNG/SGYT/KS/G
HCDR3:
(SEQ ID NO: 6543)
ARGANWHDTA/HLD
LCDR1:
(SEQ ID NO: 6569)
L/V/S/IS/TYL/VNWY
LCDR2:
(SEQ ID NO:)
LL/VIYAA/V/TT/SSR/LA/H/Q
LCDR3:
(SEQ ID NO: 6571)
QQSY/DD/E/S/NS/T/N/LPL

TABLE 2D
Group IV Antibody Sequences
Ab	VH sequence	VL sequence
365_A08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	SSYSMNWVRQAPGKGLEWVASINYNGGYK	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1477)
	TVSS (SEQ ID NO: 1384)
365_A09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYGMHWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1478)
	TVSS (SEQ ID NO: 1385)
365_C02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN
	DSYSMNWVRQAPGKGLEWVSNINYNGGYK	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1479)
	TVSS (SEQ ID NO: 1386)
365_C04	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	DSYSMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1480)
	TVSS (SEQ ID NO: 1387)
365_D02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	SSYSMHWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1481)
	TVSS (SEQ ID NO: 1388)
365_D07	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	SSYGMNWVRQAPGKGLEWVSSINYNSGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1482)
	TVSS (SEQ ID NO: 1389)
365_D10	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1483)
	TVSS (SEQ ID NO: 1390)
365_E11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	DDYSMNWVRQAPGKGLEWVSSINYNGGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1484)
	TVSS (SEQ ID NO: 1391)
365_F05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	SSYGMNWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1485)
	TVSS (SEQ ID NO: 1392)
365_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	SSYGMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1486)
	TVSS (SEQ ID NO: 1393)
366_D08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYGMHWVRQAPGKGLEWVSNINYNGGYK	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1487)
	TVSS (SEQ ID NO: 1394)
366_F08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	SSYGMNWVRQAPGKGLEWVSSINYNGGYT	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1488)
	TVSS (SEQ ID NO: 1395)
366_G09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	DDYSMNWVRQAPGKGLEWVASINYNSGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1489)
	TVSS (SEQ ID NO: 1396)
367_A02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	DSYGMNWVRQAPGKGLEWVSSINYNSGYK	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1490)
	TVSS (SEQ ID NO: 1397)
367_B06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	SSYSMNWVRQAPGKGLEWVANINYNGGYT	WYQQKPGKAPKLVIYAATSLHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1491)
	TVSS (SEQ ID NO: 1398)
367_C08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	DSYSMHWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSDSNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1492)
	TVSS (SEQ ID NO: 1399)
367_D05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	SDYSMNWVRQAPGKGLEWVSSINYNGGYK	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1493)
	TVSS (SEQ ID NO: 1400)
367_D09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	DSYGMNWVRQAPGKGLEWVASINYNGGYK	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1494)
	TVSS (SEQ ID NO: 1401)
367_E07	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SDYSMNWVRQAPGKGLEWVSSINYNGGYK	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1495)
	TVSS (SEQ ID NO: 1402)
367_E12	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	SSYGMHWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1496)
	TVSS (SEQ ID NO: 1403)
367_F09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	DSYSMHWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSDSNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1497)
	TVSS (SEQ ID NO: 1404)
367_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYGMHWVRQAPGKGLEWVASINYNSGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1498)
	TVSS (SEQ ID NO: 1405)
367_H10	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYGMNWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1499)
	TVSS (SEQ ID NO: 1406)
368_B02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	SSYGMNWVRQAPGKGLEWVSGINYNSGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1500)
	TVSS (SEQ ID NO: 1407)
368_C11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	SDYSMNWVRQAPGKGLEWVSSINYNSGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1501)
	TVSS (SEQ ID NO: 1408)
368_D02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN
	DDYGMNWVRQAPGKGLEWVSNINYNGGYT	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1502)
	TVSS (SEQ ID NO: 1409)
368_D12	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYGMNWVRQAPGKGLEWVSSINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1503)
	TVSS (SEQ ID NO: 1410)
368_F06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	DDYSMHWVRQAPGKGLEWVANINYNSGYT	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1504)
	TVSS (SEQ ID NO: 1411)
368_G03	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SSYSMNWVRQAPGKGLEWVSGINYNSGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTALDYWGQGTLV	KVEIK (SEQ ID NO: 1505)
	TVSS (SEQ ID NO: 1412)
368_G10	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	SSYSMHWVRQAPGKGLEWVSSINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1506)
	TVSS (SEQ ID NO: 1413)
368_H06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	DSYGMHWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1507)
	TVSS (SEQ ID NO: 1414)
368_H11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	DSYGMHWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSDDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1508)
	TVSS (SEQ ID NO: 1415)
369_A11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	DSYGMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1509)
	TVSS (SEQ ID NO: 1416)
369_C12	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYGMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1510)
	TVSS (SEQ ID NO: 1417)
369_D08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SDYSMNWVRQAPGKGLEWVASINYNGGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1511)
	TVSS (SEQ ID NO: 1418)
369_E05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SDYGMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1512)
	TVSS (SEQ ID NO: 1419)
369_E08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	SSYSMNWVRQAPGKGLEWVASINYNSGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1513)
	TVSS (SEQ ID NO: 1420)
369_F05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQGYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1514)
	TVSS (SEQ ID NO: 1421)
369_F09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	SSYGMHWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1515)
	TVSS (SEQ ID NO: 1422)
369_G05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1516)
	TVSS (SEQ ID NO: 1423)
369_H02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	DDYSMNWVRQAPGKGLEWVSNINYNGGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1517)
	TVSS (SEQ ID NO: 1424)
369_H08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYSMNWVRQAPGKGLEWVAGINYNSGYK	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1518)
	TVSS (SEQ ID NO: 1425)
369_H12	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYK	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1519)
	TVSS (SEQ ID NO: 1426)
370_B08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SDYSMNWVRQAPGKGLEWVANINYNGGYT	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1520)
	TVSS (SEQ ID NO: 1427)
370_C06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	SSYSMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1521)
	TVSS (SEQ ID NO: 1428)
370_C07	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SSYSMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1522)
	TVSS (SEQ ID NO: 1429)
370_C10	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	DSYSMNWVRQAPGKGLEWVSNINYNSGYK	WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1523)
	TVSS (SEQ ID NO: 1430)
370_D03	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	SSYSMNWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1524)
	TVSS (SEQ ID NO: 1431)
370_D09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	SDYSMNWVRQAPGKGLEWVSGINYNSGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1525)
	TVSS (SEQ ID NO: 1432)
370_E04	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYAVTSLHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1526)
	TVSS (SEQ ID NO: 1433)
370_E05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN
	SSYGMNWVRQAPGKGLEWVSNINYNGGYK	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1527)
	TVSS (SEQ ID NO: 1434)
370_F01	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	SSYGMNWVRQAPGKGLEWVSNINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1528)
	TVSS (SEQ ID NO: 1435)
370_F02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	DSYGMNWVRQAPGKGLEWVANINYNGGYT	WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1529)
	TVSS (SEQ ID NO: 1436)
370_F12	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SDYSMNWVRQAPGKGLEWVANINYNGGYT	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1530)
	TVSS (SEQ ID NO: 1437)
370_G08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SDYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1531)
	TVSS (SEQ ID NO: 1438)
370_H04	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYSMNWVRQAPGKGLEWVSNINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1532)
	TVSS (SEQ ID NO: 1439)
370_H06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	DDYSMNWVRQAPGKGLEWVANINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1533)
	TVSS (SEQ ID NO: 1440)
371_B01	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	DSYSMNWVRQAPGKGLEWVSNINYNSGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1534)
	TVSS (SEQ ID NO: 1441)
371_C06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	SSYSMNWVRQAPGKGLEWVSSINYNGGYT	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1535)
	TVSS (SEQ ID NO: 1442)
371_C07	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	DSYGMNWVRQAPGKGLEWVSNINYNGGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTALDYWGQGTLV	KVEIK (SEQ ID NO: 1536)
	TVSS (SEQ ID NO: 1443)
371_E05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1537)
	TVSS (SEQ ID NO: 1444)
371_E08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	SSYSMNWVRQAPGKGLEWVSNINYNSGYK	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1538)
	TVSS (SEQ ID NO: 1445)
371_E09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SDYSMNWVRQAPGKGLEWVSGINYNSGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1539)
	TVSS (SEQ ID NO: 1446)
371_E12	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	DSYSMNWVRQAPGKGLEWVSGINYNSGYK	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1540)
	TVSS (SEQ ID NO: 1447)
371_F03	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYT	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1541)
	TVSS (SEQ ID NO: 1448)
371_F09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1542)
	TVSS (SEQ ID NO: 1449)
371_G01	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SDYSMNWVRQAPGKGLEWVSNINYNGGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1543)
	TVSS (SEQ ID NO: 1450)
371_H11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYK	WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1544)
	TVSS (SEQ ID NO: 1451)
372_B09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVSSINYNSGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1545)
	TVSS (SEQ ID NO: 1452)
372_E08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	SDYSMNWVRQAPGKGLEWVSNINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1546)
	TVSS (SEQ ID NO: 1453)
372_F02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYGMHWVRQAPGKGLEWVASINYNGGYT	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1547)
	TVSS (SEQ ID NO: 1454)
372_H11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYGMHWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1548)
	TVSS (SEQ ID NO: 1455)
373_A06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1549)
	TVSS (SEQ ID NO: 1456)
373_B09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	DSYSMNWVRQAPGKGLEWVSGINYNGGYK	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1550)
	TVSS (SEQ ID NO: 1457)
373_D06	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1551)
	TVSS (SEQ ID NO: 1458)
373_F07	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SSYSMNWVRQAPGKGLEWVSGINYNSGYK	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1552)
	TVSS (SEQ ID NO: 1459)
373_G02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1553)
	TVSS (SEQ ID NO: 1460)
374_A04	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1554)
	TVSS (SEQ ID NO: 1461)
374_A05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLN
	SDYGMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1555)
	TVSS (SEQ ID NO: 1462)
374_C10	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	SSYSMNWVRQAPGKGLEWVSSINYNGGYK	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1556)
	TVSS (SEQ ID NO: 1463)
374_D04	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1557)
	TVSS (SEQ ID NO: 1464)
374_D09	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	DSYGMNWVRQAPGKGLEWVANINYNGGYK	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1558)
	TVSS (SEQ ID NO: 1465)
374_G05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	SSYSMNWVRQAPGKGLEWVSNINYNSGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1559)
	TVSS (SEQ ID NO: 1466)
374_H05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1560)
	TVSS (SEQ ID NO: 1467)
375_A03	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	DSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1561)
	TVSS (SEQ ID NO: 1468)
375_B03	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYT	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1562)
	TVSS (SEQ ID NO: 1469)
375 C01	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	SSYGMNWVRQAPGKGLEWVSSINYNGGYK	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1563)
	TVSS (SEQ ID NO: 1470)
375_C11	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	SSYSMNWVRQAPGKGLEWVSSINYNGGYT	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1564)
	TVSS (SEQ ID NO: 1471)
375_F10	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYT	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1565)
	TVSS (SEQ ID NO: 1472)
375_H08	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYT	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1566)
	TVSS (SEQ ID NO: 1473)
376_A02	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	SSYSMNWVRQAPGKGLEWVAGINYNGGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1567)
	TVSS (SEQ ID NO: 1474)
376_A05	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVAGINYNSGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	GYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1568)
	TVSS (SEQ ID NO: 1475)
376_A07	EVQLLESGGGLVQPGGSLRLSCAASGFTF	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	SSYSMNWVRQAPGKGLEWVSGINYNGGYK	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	SYADSVKGRFTISRDNSKNTLYLQMNSLR	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	AEDTAVYYCARGATWHDTHLDYWGQGTLV	KVEIK (SEQ ID NO: 1569)
	TVSS (SEQ ID NO: 1476)

Table 3D provides the amino acid sequences of the CDRs of the antibodies shown in Table 2D.

TABLE 3D
CDR sequences for Group IV antibodies
Ab	HCDR1	HCDR2	HCDR3	LCDR1	LCDR2	LCDR3
365_A08	SSYSMN	WVASINYNGGYKS	ARGATWHDTHLD	ITYLNWY	LVIYAATSRA	QQSDNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1663)	1756)	NO:	NO: 1942)	NO:
	1570)			1849)		2035)
365_A09	SSYGMH	WVASINYNGGYTS	ARGATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1664)	1757)	NO:	NO: 1943)	NO:
	1571)			1850)		2036)
365_C02	DSYSMN	WVSNINYNGGYKG	ARGATWHDTHLD	STYLNWY	LVIYAATSRH	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1665)	1758)	NO:	NO: 1944)	NO:
	1572)			1851)		2037)
365_C04	DSYSMN	WVANINYNGGYKG	ARGATWHDTHLD	LTYLNWY	LVIYAATSLA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1666)	1759)	NO:	NO: 1945)	NO:
	1573)			1852)		2038)
365_D02	SSYSMH	WVASINYNGGYTS	ARGATWHDTHLD	VTYLNWY	LLIYAATSLA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1667)	1760)	NO:	NO: 1946)	NO:
	1574)			1853)		2039)
365_D07	SSYGMN	WVSSINYNSGYKS	ARGATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1668)	1761)	NO:	NO: 1947)	NO:
	1575)			1854)		2040)
365_D10	SSYSMN	WVAGINYNGGYTG	ARGATWHDTHLD	STYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1669)	1762)	NO:	NO: 1948)	NO:
	1576)			1855)		2041)
365_E11	DDYSMN	WVSSINYNGGYKS	ARGATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1670)	1763)	NO:	NO: 1949)	NO:
	1577)			1856)		2042)
365_F05	SSYGMN	WVASINYNGGYTS	ARGATWHDTHLD	VTYVNWY	LLIYAATSRA	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1671)	1764)	NO:	NO: 1950)	NO:
	1578)			1857)		2043)
365_H05	SSYGMN	WVAGINYNGGYTS	ARGATWHDTHLD	LTYVNWY	LLIYAATSLH	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1672)	1765)	NO:	NO: 1951)	NO:
	1579)			1858)		2044)
366_D08	SSYGMH	WVSNINYNGGYKS	ARGATWHDTHLD	LSYVNWY	LVIYAATSLA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1673)	1766)	NO:	NO: 1952)	NO:
	1580)			1859)		2045)
366_F08	SSYGMN	WVSSINYNGGYTS	ARGATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1674)	1767)	NO:	NO: 1953)	NO:
	1581)			1860)		2046)
366_G09	DDYSMN	WVASINYNSGYTG	ARGATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1675)	1768)	NO:	NO: 1954)	NO:
	1582)			1861)		2047)
367_A02	DSYGMN	WVSSINYNSGYKG	ARGATWHDTHLD	ISYLNWY	LLIYAVTSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1676)	1769)	NO:	NO: 1955)	NO:
	1583)			1862)		2048)
367_B06	SSYSMN	WVANINYNGGYTG	ARGATWHDTHLD	ISYVNWY	LVIYAATSLH	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1677)	1770)	NO:	NO: 1956)	NO:
	1584)			1863)		2049)
367_C08	DSYSMH	WVAGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSDSNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1678)	1771)	NO:	NO: 1957)	NO:
	1585)			1864)		2050)
367_D05	SDYSMN	WVSSINYNGGYKS	ARGATWHDTHLD	ISYVNWY	LVIYAATSLA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1679)	1772)	NO:	NO: 1958)	NO:
	1586)			1865)		2051)
367_D09	DSYGMN	WVASINYNGGYKS	ARGATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1680)	1773)	NO:	NO: 1959)	NO:
	1587)			1866)		2052)
367_E07	SDYSMN	WVSSINYNGGYKG	ARGATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1681)	1774)	NO:	NO: 1960)	NO:
	1588)			1867)		2053)
367_E12	SSYGMH	WVASINYNGGYTS	ARGATWHDTHLD	LTYVNWY	LLIYAASSLQ	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1682)	1775)	NO:	NO: 1961)	NO:
	1589)			1868)		2054)
367_F09	DSYSMH	WVAGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSDSNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1683)	1776)	NO:	NO: 1962)	NO:
	1590)			1869)		2055)
367 H05	SSYGMH	WVASINYNSGYKS	ARGATWHDTHLD	LSYVNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	NO:	NO:	1870)	NO: 1963)	2056)
	1591)	1684)	1777)
367_H10	SSYGMN	WVASINYNGGYTG	ARGATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1685)	1778)	NO:	NO: 1964)	NO:
	1592)			1871)		2057)
368_B02	SSYGMN	WVSGINYNSGYKS	ARGATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1686)	1779)	NO:	NO: 1965)	NO:
	1593)			1872)		2058)
368_C11	SDYSMN	WVSSINYNSGYKS	ARGATWHDTHLD	ISYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1687)	1780)	NO:	NO: 1966)	NO:
	1594)			1873)		2059)
368_D02	DDYGMN	WVSNINYNGGYTG	ARGATWHDTHLD	STYLNWY	LVIYAATSRH	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1688)	1781)	NO:	NO: 1967)	NO:
	1595)			1874)		2060)
368_D12	SSYGMN	WVSSINYNGGYTS	ARGATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYNNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1689)	1782)	NO:	NO: 1968)	NO:
	1596)			1875)		2061)
368_F06	DDYSMH	WVANINYNSGYTG	ARGATWHDTHLD	LSYLNWY	LVIYATTSRA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1690)	1783)	NO:	NO: 1969)	NO:
	1597)			1876)		2062)
368_G03	SSYSMN	WVSGINYNSGYTS	ARGATWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1691)	1784)	NO:	NO: 1970)	NO:
	1598)			1877)		2063)
368_G10	SSYSMH	WVSSINYNGGYTS	ARGATWHDTHLD	VSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1692)	1785)	NO:	NO: 1971)	NO:
	1599)			1878)		2064)
368_H06	DSYGMH	WVANINYNGGYKS	ARGATWHDTHLD	LTYVNWY	LLIYATTSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1693)	1786)	NO:	NO: 1972)	NO:
	1600)			1879)		2065)
368_H11	DSYGMH	WVASINYNGGYTS	ARGATWHDTHLD	LSYLNWY	LLIYAATSRA	QQSDDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1694)	1787)	NO:	NO: 1973)	NO:
	1601)			1880)		2066)
369_A11	DSYGMN	WVANINYNGGYKG	ARGATWHDTHLD	ITYLNWY	LVIYAATSRH	QQSYESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1695)	1788)	NO:	NO: 1974)	NO:
	1602)			1881)		2067)
369_C12	SSYGMN	WVANINYNGGYKG	ARGATWHDTHLD	LTYLNWY	LLIYAATSRH	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1696)	1789)	NO:	NO: 1975)	NO:
	1603)			1882)		2068)
369_D08	SDYSMN	WVASINYNGGYKG	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1697)	1790)	NO:	NO: 1976)	NO:
	1604)			1883)		2069)
369_E05	SDYGMN	WVANINYNGGYKS	ARGATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1698)	1791)	NO:	NO: 1977)	NO:
	1605)			1884)		2070)
369_E08	SSYSMN	WVASINYNSGYTG	ARGATWHDTHLD	LTYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1699)	1792)	NO:	NO: 1978)	NO:
	1606)			1885)		2071)
369_F05	SSYSMN	WVSGINYNGGYKS	ARGATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQGYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1700)	1793)	NO:	NO: 1979)	NO:
	1607)			1886)		2072)
369_F09	SSYGMH	WVAGINYNGGYTS	ARGATWHDTHLD	LTYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1701)	1794)	NO:	NO: 1980)	NO:
	1608)			1887)		2073)
369_G05	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	VSYLNWY	LLIYAATSRH	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1702)	1795)	NO:	NO: 1981)	NO:
	1609)			1888)		2074)
369_H02	DDYSMN	WVSNINYNGGYKS	ARGATWHDTHLD	ISYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1703)	1796)	NO:	NO: 1982)	NO:
	1610)			1889)		2075)
369_H08	SSYSMN	WVAGINYNSGYKS	ARGATWHDTHLD	LSYVNWY	LVIYAATSLA	QQSYESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1704)	1797)	NO:	NO: 1983)	NO:
	1611)			1890)		2076)
369_H12	SSYSMN	WVAGINYNGGYKS	ARGATWHDTHLD	VTYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1705)	1798)	NO:	NO: 1984)	NO:
	1612)			1891)		2077)
370_B08	SDYSMN	WVANINYNGGYTG	ARGATWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1706)	1799)	NO:	NO: 1985)	NO:
	1613)			1892)		2078)
370_C06	SSYSMN	WVANINYNGGYKS	ARGATWHDTHLD	LTYVNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1707)	1800)	NO:	NO: 1986)	NO:
	1614)			1893)		2079)
370_C07	SSYSMN	WVANINYNGGYKS	ARGATWHDTHLD	LSYLNWY	LLIYAATSRH	QQSYESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1708)	1801)	NO:	NO: 1987)	NO:
	1615)			1894)		2080)
370_C10	DSYSMN	WVSNINYNSGYKG	ARGATWHDTHLD	VSYVNWY	LLIYATTSRA	QQSYSSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1709)	1802)	NO:	NO: 1988)	NO:
	1616)			1895)		2081)
370_D03	SSYSMN	WVASINYNGGYTS	ARGATWHDTHLD	ITYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1710)	1803)	NO:	NO: 1989)	NO:
	1617)			1896)		2082)
370_D09	SDYSMN	WVSGINYNSGYTS	ARGATWHDTHLD	VTYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1711)	1804)	NO:	NO: 1990)	NO:
	1618)			1897)		2083)
370_E04	SSYSMN	WVANINYNGGYKG	ARGATWHDTHLD	LTYLNWY	LLIYAVTSLH	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1712)	1805)	NO:	NO: 1991)	NO:
	1619)			1898)		2084)
370_E05	SSYGMN	WVSNINYNGGYKG	ARGATWHDTHLD	STYLNWY	LVIYAVTSRA	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1713)	1806)	NO:	NO: 1992)	NO:
	1620)			1899)		2085)
370_F01	SSYGMN	WVSNINYNGGYTS	ARGATWHDTHLD	VSYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1714)	1807)	NO:	NO: 1993)	NO:
	1621)			1900)		2086)
370_F02	DSYGMN	WVANINYNGGYTG	ARGATWHDTHLD	LSYLNWY	LLIYAVTSRH	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1715)	1808)	NO:	NO: 1994)	NO:
	1622)			1901)		2087)
370_F12	SDYSMN	WVANINYNGGYTG	ARGATWHDTHLD	LSYLNWY	LLIYAASSLQ	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1716)	1809)	NO:	NO: 1995)	NO:
	1623)			1902)		2088)
370_G08	SDYSMN	WVAGINYNGGYTG	ARGATWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1717)	1810)	NO:	NO: 1996)	NO:
	1624)			1903)		2089)
370_H04	SSYSMN	WVSNINYNGGYTG	ARGATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1718)	1811)	NO:	NO: 1997)	NO:
	1625)			1904)		2090)
370_H06	DDYSMN	WVANINYNGGYTG	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1719)	1812)	NO:	NO: 1998)	NO:
	1626)			1905)		2091)
371_B01	DSYSMN	WVSNINYNSGYTG	ARGATWHDTHLD	LSYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1720)	1813)	NO:	NO: 1999)	NO:
	1627)			1906)		2092)
371_C06	SSYSMN	WVSSINYNGGYTS	ARGATWHDTHLD	SSYLNWY	LLIYAVTSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1721)	1814)	NO:	NO: 2000)	NO:
	1628)			1907)		2093)
371_C07	DSYGMN	WVSNINYNGGYTG	ARGATWHDTALD	LSYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1722)	1815)	NO:	NO: 2001)	NO:
	1629)			1908)		2094)
371_E05	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	ISYLNWY	LVIYAATSRA	QQSYSSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1723)	1816)	NO:	NO: 2002)	NO:
	1630)			1909)		2095)
371_E08	SSYSMN	WVSNINYNSGYKS	ARGATWHDTHLD	VSYVNWY	LVIYAATSRH	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1724)	1817)	NO:	NO: 2003)	NO:
	1631)			1910)		2096)
371_E09	SDYSMN	WVSGINYNSGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYNSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1725)	1818)	NO:	NO: 2004)	NO:
	1632)			1911)		2097)
371_E12	DSYSMN	WVSGINYNSGYKS	ARGATWHDTHLD	LSYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1726)	1819)	NO:	NO: 2005)	NO:
	1633)			1912)		2098)
371_F03	SSYSMN	WVSGINYNGGYTS	ARGATWHDTHLD	ITYLNWY	LLIYAATSLH	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1727)	1820)	NO:	NO: 2006)	NO:
	1634)			1913)		2099)
371_F09	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1728)	1821)	NO:	NO: 2007)	NO:
	1635)			1914)		2100)
371_G01	SDYSMN	WVSNINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1729)	1822)	NO:	NO: 2008)	NO:
	1636)			1915)		2101)
371_H11	SSYSMN	WVSGINYNGGYKG	ARGATWHDTHLD	LTYLNWY	LLIYATTSRH	QQSYESPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1730)	1823)	NO:	NO: 2009)	NO:
	1637)			1916)		2102)
372_B09	SSYSMN	WVSSINYNSGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1731)	1824)	NO:	NO: 2010)	NO:
	1638)			1917)		2103)
372_E08	SDYSMN	WVSNINYNGGYTS	ARGATWHDTHLD	ITYLNWY	LLIYAATSRA	QQSYNLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1732)	1825)	NO:	NO: 2011)	NO:
	1639)			1918)		2104)
372_F02	SSYGMH	WVASINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LVIYAATSRH	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1733)	1826)	NO:	NO: 2012)	NO:
	1640)			1919)		2105)
372_H11	SSYGMH	WVAGINYNGGYTS	ARGATWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYENPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1734)	1827)	NO:	NO: 2013)	NO:
	1641)			1920)		2106)
373_A06	SSYSMN	WVSGINYNGGYKS	ARGATWHDTHLD	VTYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1735)	1828)	NO:	NO: 2014)	NO:
	1642)			1921)		2107)
373_B09	DSYSMN	WVSGINYNGGYKS	ARGATWHDTHLD	LSYLNWY	LVIYAATSLA	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1736)	1829)	NO:	NO: 2015)	NO:
	1643)			1922)		2108)
373_D06	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	VTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1737)	1830)	NO:	NO: 2016)	NO:
	1644)			1923)		2109)
373_F07	SSYSMN	WVSGINYNSGYKS	ARGATWHDTHLD	LSYLNWY	LLIYAATSLA	QQSYETPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1738)	1831)	NO:	NO: 2017)	NO:
	1645)			1924)		2110)
373_G02	SSYSMN	WVSGINYNGGYTS	ARGATWHDTHLD	ITYLNWY	LLIYAATSRA	QQSYSSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1739)	1832)	NO:	NO: 2018)	NO:
	1646)			1925)		2111)
374_A04	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1740)	1833)	NO:	NO: 2019)	NO:
	1647)			1926)		2112)
374_A05	SDYGMN	WVANINYNGGYKG	ARGATWHDTHLD	VRYLNWY	LVIYAATSLA	QQSYELPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1741)	1834)	NO:	NO: 2020)	NO:
	1648)			1927)		2113)
374_C10	SSYSMN	WVSSINYNGGYKG	ARGATWHDTHLD	VTYLNWY	LLIYAATSLA	QQSYNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1742)	1835)	NO:	NO: 2021)	NO:
	1649)			1928)		2114)
374_D04	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	LSYLNWY	LVIYAATSRH	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1743)	1836)	NO:	NO: 2022)	NO:
	1650)			1929)		2115)
374_D09	DSYGMN	WVANINYNGGYKG	ARGATWHDTHLD	ISYVNWY	LLIYAATSLA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1744)	1837)	NO:	NO: 2023)	NO:
	1651)			1930)		2116)
374_G05	SSYSMN	WVSNINYNSGYKG	ARGATWHDTHLD	ISYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1745)	1838)	NO:	NO: 2024)	NO:
	1652)			1931)		2117)
374_H05	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1746)	1839)	NO:	NO: 2025)	NO:
	1653)			1932)		2118)
375_A03	DSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSRH	QQSYDNPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1747)	1840)	NO:	NO: 2026)	NO:
	1654)			1933)		2119)
375_B03	SSYSMN	WVAGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1748)	1841)	NO:	NO: 2027)	NO:
	1655)			1934)		2120)
375_C01	SSYGMN	WVSSINYNGGYKG	ARGATWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1749)	1842)	NO:	NO: 2028)	NO:
	1656)			1935)		2121)
375_C11	SSYSMN	WVSSINYNGGYTS	ARGATWHDTHLD	LSYVNWY	LLIYAATSRH	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1750)	1843)	NO:	NO: 2029)	NO:
	1657)			1936)		2122)
375_F10	SSYSMN	WVSGINYNGGYTG	ARGATWHDTHLD	LTYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1751)	1844)	NO:	NO: 2030)	NO:
	1658)			1937)		2123)
375_H08	SSYSMN	WVSGINYNGGYTS	ARGATWHDTHLD	LTYLNWY	LLIYAATSLA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1752)	1845)	NO:	NO: 2031)	NO:
	1659)			1938)		2124)
376_A02	SSYSMN	WVAGINYNGGYKS	ARGATWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1753)	1846)	NO:	NO: 2032)	NO:
	1660)			1939)		2125)
376_A05	SSYSMN	WVAGINYNSGYKG	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYNTPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1754)	1847)	NO:	NO: 2033)	NO:
	1661)			1940)		2126)
376_A07	SSYSMN	WVSGINYNGGYKS	ARGATWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	(SEQ ID NO:	(SEQ ID NO:	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	1755)	1848)	NO:	NO: 2034)	NO:
	1662)			1941)		2127)

The consensus sequences for each of these CDRs shown in FIG. 3D are as follows:

HCDR1:
(SEQ ID NO: 6574)
S/DS/DYS/GMN/H
HCDR2:
(SEQ ID NO: 6575)
WVA/SG/N/SINYNG/SGYT/KS/G
HCDR3:
(SEQ ID NO: 6595)
ARGATWHDTH/ALD
LCDR1:
(SEQ ID NO: 6596)
L/I/V/SS/TYL/VNWY
LCDR2:
(SEQ ID NO: 6571)
LL/VIYAA/V/TT/SSR/LA/H/Q
LCDR3:
(SEQ ID NO: 6577)
QQSY/DD/E/S/NT/S/N/LPL

TABLE 2E
Group V Antibody Sequences
Ab	VH sequence	VL sequence
365_A03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2376)
	GTLVTVSS (SEQ ID NO: 2128)
365_A11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDDYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2377)
	GTLVTVSS (SEQ ID NO: 2129)
365_A12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMHWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2378)
	GTLVTVSS (SEQ ID NO: 2130)
365_B01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FDSYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2379)
	GTLVTVSS (SEQ ID NO: 2131)
365_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYGMHWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2380)
	GTLVTVSS (SEQ ID NO: 2132)
365_B07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2381)
	GTLVTVSS (SEQ ID NO: 2133)
365_B11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYGMHWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYATTSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2382)
	GTLVTVSS (SEQ ID NO: 2134)
365_C01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2383)
	GTLVTVSS (SEQ ID NO: 2135)
365_C10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2384)
	GTLVTVSS (SEQ ID NO: 2136)
365_C11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2385)
	GTLVTVSS (SEQ ID NO: 2137)
365_C12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2386)
	GTLVTVSS (SEQ ID NO: 2138)
365_D09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMHWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2387)
	GTLVTVSS (SEQ ID NO: 2139)
365_D11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2388)
	GTLVTVSS (SEQ ID NO: 2140)
365_D12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2389)
	GTLVTVSS (SEQ ID NO: 2141)
365_E01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSDYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2390)
	GTLVTVSS (SEQ ID NO: 2142)
365_E05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMHWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2391)
	GTLVTVSS (SEQ ID NO: 2143)
365_E07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYGMHWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2392)
	GTLVTVSS (SEQ ID NO: 2144)
365_E09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2393)
	GTLVTVSS (SEQ ID NO: 2145)
365_F01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2394)
	GTLVTVSS (SEQ ID NO: 2146)
365_F06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2395)
	GTLVTVSS (SEQ ID NO: 2147)
365_F12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSDYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2396)
	GTLVTVSS (SEQ ID NO: 2148)
365_G01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2397)
	GTLVTVSS (SEQ ID NO: 2149)
365_G11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2398)
	GTLVTVSS (SEQ ID NO: 2150)
365_H02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2399)
	GTLVTVSS (SEQ ID NO: 2151)
365_H03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSLHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2400)
	GTLVTVSS (SEQ ID NO: 2152)
365_H06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2401)
	GTLVTVSS (SEQ ID NO: 2153)
365_H10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	FDSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2402)
	GTLVTVSS (SEQ ID NO: 2154)
365_H11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2403)
	GTLVTVSS (SEQ ID NO: 2155)
365_H12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2404)
	GTLVTVSS (SEQ ID NO: 2156)
366_A07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2405)
	GTLVTVSS (SEQ ID NO: 2157)
366_B08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2406)
	GTLVTVSS (SEQ ID NO: 2158)
366_B10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2407)
	GTLVTVSS (SEQ ID NO: 2159)
366_B12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2408)
	GTLVTVSS (SEQ ID NO: 2160)
366_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2409)
	GTLVTVSS (SEQ ID NO: 2161)
366_E10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2410)
	GTLVTVSS (SEQ ID NO: 2162)
366_F04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYATTSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2411)
	GTLVTVSS (SEQ ID NO: 2163)
366_F05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2412)
	GTLVTVSS (SEQ ID NO: 2164)
366_F07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSDYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2413)
	GTLVTVSS (SEQ ID NO: 2165)
	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
366_G04	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2414)
	GTLVTVSS (SEQ ID NO: 2166)
	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
366_G05	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2415)
	GTLVTVSS (SEQ ID NO: 2167)
366_H06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2416)
	GTLVTVSS (SEQ ID NO: 2168)
366_H07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSSYGMHWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2417)
	GTLVTVSS (SEQ ID NO: 2169)
366_H08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYGMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2418)
	GTLVTVSS (SEQ ID NO: 2170)
366_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2419)
	GTLVTVSS (SEQ ID NO: 2171)
367_A04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2420)
	GTLVTVSS (SEQ ID NO: 2172)
367_A05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2421)
	GTLVTVSS (SEQ ID NO: 2173)
367_B02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2422)
	GTLVTVSS (SEQ ID NO: 2174)
367_B03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2423)
	GTLVTVSS (SEQ ID NO: 2175)
367_B07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSDYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2424)
	GTLVTVSS (SEQ ID NO: 2176)
367_B08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2425)
	GTLVTVSS (SEQ ID NO: 2177)
367_C01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDDYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYATTSLHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2426)
	GTLVTVSS (SEQ ID NO: 2178)
367_C05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2427)
	GTLVTVSS (SEQ ID NO: 2179)
367_C11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2428)
	GTLVTVSS (SEQ ID NO: 2180)
367_D10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2429)
	GTLVTVSS (SEQ ID NO: 2181)
367_E01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYATTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2430)
	GTLVTVSS (SEQ ID NO: 2182)
367_E04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYSMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2431)
	GTLVTVSS (SEQ ID NO: 2183)
367_E06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2432)
	GTLVTVSS (SEQ ID NO: 2184)
367_E09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYGMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2433)
	GTLVTVSS (SEQ ID NO: 2185)
367_E11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2434)
	GTLVTVSS (SEQ ID NO: 2186)
367_F03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2435)
	GTLVTVSS (SEQ ID NO: 2187)
367_F07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDSYGMHWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2436)
	GTLVTVSS (SEQ ID NO: 2188)
367_F11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2437)
	GTLVTVSS (SEQ ID NO: 2189)
367_G05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSDYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2438)
	GTLVTVSS (SEQ ID NO: 2190)
367_G06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYATTSLHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2439)
	GTLVTVSS (SEQ ID NO: 2191)
367_G10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDDYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2440)
	GTLVTVSS (SEQ ID NO: 2192)
367_H06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2441)
	GTLVTVSS (SEQ ID NO: 2193)
367_H11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2442)
	GTLVTVSS (SEQ ID NO: 2194)
368_A01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2443)
	GTLVTVSS (SEQ ID NO: 2195)
368_A05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2444)
	GTLVTVSS (SEQ ID NO: 2196)
368_A07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSNELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2445)
	GTLVTVSS (SEQ ID NO: 2197)
368_A09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2446)
	GTLVTVSS (SEQ ID NO: 2198)
368_B01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2447)
	GTLVTVSS (SEQ ID NO: 2199)
368_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYGMHWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2448)
	GTLVTVSS (SEQ ID NO: 2200)
368_B07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSDYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2449)
	GTLVTVSS (SEQ ID NO: 2201)
368_C05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDSNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2450)
	GTLVTVSS (SEQ ID NO: 2202)
368_D01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMHWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2451)
	GTLVTVSS (SEQ ID NO: 2203)
368_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISTYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAVTSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2452)
	GTLVTVSS (SEQ ID NO: 2204)
368_D05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2453)
	GTLVTVSS (SEQ ID NO: 2205)
368_D11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDDYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2454)
	GTLVTVSS (SEQ ID NO: 2206)
368_E01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2455)
	GTLVTVSS (SEQ ID NO: 2207)
368_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2456)
	GTLVTVSS (SEQ ID NO: 2208)
368_E04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2457)
	GTLVTVSS (SEQ ID NO: 2209)
368_E06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYGMHWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYGATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2458)
	GTLVTVSS (SEQ ID NO: 2210)
368_E07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2459)
	GTLVTVSS (SEQ ID NO: 2211)
368_F03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2460)
	GTLVTVSS (SEQ ID NO: 2212)
368_F11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2461)
	GTLVTVSS (SEQ ID NO: 2213)
368_G01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2462)
	GTLVTVSS (SEQ ID NO: 2214)
368_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FSSYGMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2463)
	GTLVTVSS (SEQ ID NO: 2215)
368_H04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2464)
	GTLVTVSS (SEQ ID NO: 2216)
369_A02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2465)
	GTLVTVSS (SEQ ID NO: 2217)
369_A03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAVTSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQGYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2466)
	GTLVTVSS (SEQ ID NO: 2218)
369_B01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2467)
	GTLVTVSS (SEQ ID NO: 2219)
369_C02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2468)
	GTLVTVSS (SEQ ID NO: 2220)
369_C03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2469)
	GTLVTVSS (SEQ ID NO: 2221)
369_C04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYTTTSLHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2470)
	GTLVTVSS (SEQ ID NO: 2222)
369_D01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2471)
	GTLVTVSS (SEQ ID NO: 2223)
369_D02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2472)
	GTLVTVSS (SEQ ID NO: 2224)
369_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2473)
	GTLVTVSS (SEQ ID NO: 2225)
369_D12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2474)
	GTLVTVSS (SEQ ID NO: 2226)
369_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2475)
	GTLVTVSS (SEQ ID NO: 2227)
369_E11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2476)
	GTLVTVSS (SEQ ID NO: 2228)
369_E12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2477)
	GTLVTVSS (SEQ ID NO: 2229)
369_F01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2478)
	GTLVTVSS (SEQ ID NO: 2230)
369_F02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYGMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2479)
	GTLVTVSS (SEQ ID NO: 2231)
369_F03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2480)
	GTLVTVSS (SEQ ID NO: 2232)
369_F06	EVQLLESGGGLVQPGGSLRLSCAASGFT
	FDDYSMNWVRQAPGKGLEWVAGINYNGG	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	YKGYADSVKGRFTISRDNSKNTLYLQMN	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	SLRAEDTAVYYCARSANWHDTALDYWGQ	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	GTLVTVSS (SEQ ID NO: 2233)	KVEIK (SEQ ID NO: 2481)
369_F10	EVQLLESGGGLVQPGGSLRLSCAASGFT
	FDSYGMNWVRQAPGKGLEWVSNINYNSG	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	YKSYADSVKGRFTISRDNSKNTLYLQMN	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	SLRAEDTAVYYCARSANWHDTALDYWGQ	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	GTLVTVSS (SEQ ID NO: 2234)	KVEIK (SEQ ID NO: 2482)
369_F11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2483)
	GTLVTVSS (SEQ ID NO: 2235)
369_G01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2484)
	GTLVTVSS (SEQ ID NO: 2236)
369_G04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2485)
	GTLVTVSS (SEQ ID NO: 2237)
369_G06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2486)
	GTLVTVSS (SEQ ID NO: 2238)
369_G11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2487)
	GTLVTVSS (SEQ ID NO: 2239)
369_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2488)
	GTLVTVSS (SEQ ID NO: 2240)
369_H05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2489)
	GTLVTVSS (SEQ ID NO: 2241)
369_H06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2490)
	GTLVTVSS (SEQ ID NO: 2242)
369_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2491)
	GTLVTVSS (SEQ ID NO: 2243)
370_A01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2492)
	GTLVTVSS (SEQ ID NO: 2244)
370_A03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2493)
	GTLVTVSS (SEQ ID NO: 2245)
370_A04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2494)
	GTLVTVSS (SEQ ID NO: 2246)
370_A12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2495)
	GTLVTVSS (SEQ ID NO: 2247)
370_C01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2496)
	GTLVTVSS (SEQ ID NO: 2248)
370_C03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYYVTNRQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2497)
	GTLVTVSS (SEQ ID NO: 2249)
370_C05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2498)
	GTLVTVSS (SEQ ID NO: 2250)
370_C08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISNYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2499)
	GTLVTVSS (SEQ ID NO: 2251)
370_C09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2500)
	GTLVTVSS (SEQ ID NO: 2252)
370_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2501)
	GTLVTVSS (SEQ ID NO: 2253)
370_D11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2502)
	GTLVTVSS (SEQ ID NO: 2254)
370_E03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYYASNRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2503)
	GTLVTVSS (SEQ ID NO: 2255)
370_E06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2504)
	GTLVTVSS (SEQ ID NO: 2256)
370_E09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDSSMHWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2505)
	GTLVTVSS (SEQ ID NO: 2257)
370_F05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2506)
	GTLVTVSS (SEQ ID NO: 2258)
370_F07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2507)
	GTLVTVSS (SEQ ID NO: 2259)
370_F10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2508)
	GTLVTVSS (SEQ ID NO: 2260)
370_G02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSDYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2509)
	GTLVTVSS (SEQ ID NO: 2261)
370_G03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2510)
	GTLVTVSS (SEQ ID NO: 2262)
370_G06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYGMHWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2511)
	GTLVTVSS (SEQ ID NO: 2263)
370_G09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2512)
	GTLVTVSS (SEQ ID NO: 2264)
370_G10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FSDYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYVVNNRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2513)
	GTLVTVSS (SEQ ID NO: 2265)
370_G11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2514)
	GTLVTVSS (SEQ ID NO: 2266)
370_H01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2515)
	GTLVTVSS (SEQ ID NO: 2267)
370_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2516)
	GTLVTVSS (SEQ ID NO: 2268)
371_A03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2517)
	GTLVTVSS (SEQ ID NO: 2269)
371_A06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2518)
	GTLVTVSS (SEQ ID NO: 2270)
371_A07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2519)
	GTLVTVSS (SEQ ID NO: 2271)
371_A08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMHWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2520)
	GTLVTVSS (SEQ ID NO: 2272)
371_A12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2521)
	GTLVTVSS (SEQ ID NO: 2273)
371_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2522)
	GTLVTVSS (SEQ ID NO: 2274)
371_B07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2523)
	GTLVTVSS (SEQ ID NO: 2275)
371_C03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2524)
	GTLVTVSS (SEQ ID NO: 2276)
371_D06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDDYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2525)
	GTLVTVSS (SEQ ID NO: 2277)
371_D09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2526)
	GTLVTVSS (SEQ ID NO: 2278)
371_F01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2527)
	GTLVTVSS (SEQ ID NO: 2279)
371_F04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2528)
	GTLVTVSS (SEQ ID NO: 2280)
371_F06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2529)
	GTLVTVSS (SEQ ID NO: 2281)
371_F08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDDYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2530)
	GTLVTVSS (SEQ ID NO: 2282)
371_G05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2531)
	GTLVTVSS (SEQ ID NO: 2283)
371_G10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2532)
	GTLVTVSS (SEQ ID NO: 2284)
371_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2533)
	GTLVTVSS (SEQ ID NO: 2285)
372_A04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2534)
	GTLVTVSS (SEQ ID NO: 2286)
372_B04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2535)
	GTLVTVSS (SEQ ID NO: 2287)
372_C07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2536)
	GTLVTVSS (SEQ ID NO: 2288)
372_D02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMHWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2537)
	GTLVTVSS (SEQ ID NO: 2289)
372_F03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2538)
	GTLVTVSS (SEQ ID NO: 2290)
372_F06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2539)
	GTLVTVSS (SEQ ID NO: 2291)
372_F08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSDYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2540)
	GTLVTVSS (SEQ ID NO: 2292)
372_F09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2541)
	GTLVTVSS (SEQ ID NO: 2293)
373_A02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2542)
	GTLVTVSS (SEQ ID NO: 2294)
373_A08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2543)
	GTLVTVSS (SEQ ID NO: 2295)
373_A10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2544)
	GTLVTVSS (SEQ ID NO: 2296)
373_B04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2545)
	GTLVTVSS (SEQ ID NO: 2297)
373_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSDYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2546)
	GTLVTVSS (SEQ ID NO: 2298)
373_B10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2547)
	GTLVTVSS (SEQ ID NO: 2299)
373_B12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2548)
	GTLVTVSS (SEQ ID NO: 2300)
373_C02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2549)
	GTLVTVSS (SEQ ID NO: 2301)
373_C04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2550)
	GTLVTVSS (SEQ ID NO: 2302)
373_C06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2551)
	GTLVTVSS (SEQ ID NO: 2303)
373_C08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2552)
	GTLVTVSS (SEQ ID NO: 2304)
373_C11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2553)
	GTLVTVSS (SEQ ID NO: 2305)
373_D01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2554)
	GTLVTVSS (SEQ ID NO: 2306)
373_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2555)
	GTLVTVSS (SEQ ID NO: 2307)
373_D05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2556)
	GTLVTVSS (SEQ ID NO: 2308)
373_D08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2557)
	GTLVTVSS (SEQ ID NO: 2309)
373_D10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2558)
	GTLVTVSS (SEQ ID NO: 2310)
373_E01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2559)
	GTLVTVSS (SEQ ID NO: 2311)
373_B05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2560)
	GTLVTVSS (SEQ ID NO: 2312)
373_E07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2561)
	GTLVTVSS (SEQ ID NO: 2313)
373_E12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2562)
	GTLVTVSS (SEQ ID NO: 2314)
373_G10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2563)
	GTLVTVSS (SEQ ID NO: 2315)
373_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2564)
	GTLVTVSS (SEQ ID NO: 2316)
373_H01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2565)
	GTLVTVSS (SEQ ID NO: 2317)
373_H05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSDYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2566)
	GTLVTVSS (SEQ ID NO: 2318)
374_A07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2567)
	GTLVTVSS (SEQ ID NO: 2319)
374_B04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2568)
	GTLVTVSS (SEQ ID NO: 2320)
374_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2569)
	GTLVTVSS (SEQ ID NO: 2321)
374_B12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2570)
	GTLVTVSS (SEQ ID NO: 2322)
374_C03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2571)
	GTLVTVSS (SEQ ID NO: 2323)
374_C06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDDYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2572)
	GTLVTVSS (SEQ ID NO: 2324)
374_D01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2573)
	GTLVTVSS (SEQ ID NO: 2325)
374_D08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2574)
	GTLVTVSS (SEQ ID NO: 2326)
374_E01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2575)
	GTLVTVSS (SEQ ID NO: 2327)
374_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2576)
	GTLVTVSS (SEQ ID NO: 2328)
374_E05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSFVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2577)
	GTLVTVSS (SEQ ID NO: 2329)
374_E07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN
	FSDYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2578)
	GTLVTVSS (SEQ ID NO: 2330)
374_E08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2579)
	GTLVTVSS (SEQ ID NO: 2331)
374_E11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2580)
	GTLVTVSS (SEQ ID NO: 2332)
374_F01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2581)
	GTLVTVSS (SEQ ID NO: 2333)
374_F02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2582)
	GTLVTVSS (SEQ ID NO: 2334)
374_F04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2583)
	GTLVTVSS (SEQ ID NO: 2335)
374_F10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2584)
	GTLVTVSS (SEQ ID NO: 2336)
374_F11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2585)
	GTLVTVSS (SEQ ID NO: 2337)
374_G04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2586)
	GTLVTVSS (SEQ ID NO: 2338)
374_G06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2587)
	GTLVTVSS (SEQ ID NO: 2339)
374_G07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2588)
	GTLVTVSS (SEQ ID NO: 2340)
374_H03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2589)
	GTLVTVSS (SEQ ID NO: 2341)
374_H04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2590)
	GTLVTVSS (SEQ ID NO: 2342)
374_H06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2591)
	GTLVTVSS (SEQ ID NO: 2343)
374_H07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2592)
	GTLVTVSS (SEQ ID NO: 2344)
374_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2593)
	GTLVTVSS (SEQ ID NO: 2345)
375_A05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2594)
	GTLVTVSS (SEQ ID NO: 2346)
375_C06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDDYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2595)
	GTLVTVSS (SEQ ID NO: 2347)
375_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDSSMHWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCAKSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2596)
	GTLVTVSS (SEQ ID NO: 2348)
375_D05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTHLDYWGQ	KVEIK (SEQ ID NO: 2597)
	GTLVTVSS (SEQ ID NO: 2349)
375_D07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSSYGMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2598)
	GTLVTVSS (SEQ ID NO: 2350)
375_D08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSDYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2599)
	GTLVTVSS (SEQ ID NO: 2351)
375_D12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2600)
	GTLVTVSS (SEQ ID NO: 2352)
375_E01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2601)
	GTLVTVSS (SEQ ID NO: 2353)
375_E07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSDYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYVVTNRESGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2602)
	GTLVTVSS (SEQ ID NO: 2354)
375_H12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYYVTNRQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSIPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2603)
	GTLVTVSS (SEQ ID NO: 2355)
376_A04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2604)
	GTLVTVSS (SEQ ID NO: 2356)
376_A10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYGMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2605)
	GTLVTVSS (SEQ ID NO: 2357)
376_A12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2606)
	GTLVTVSS (SEQ ID NO: 2358)
376_B04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2607)
	GTLVTVSS (SEQ ID NO: 2359)
376_B05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2608)
	GTLVTVSS (SEQ ID NO: 2360)
376_B09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2609)
	GTLVTVSS (SEQ ID NO: 2361)
376_B11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2610)
	GTLVTVSS (SEQ ID NO: 2362)
376_C01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2611)
	GTLVTVSS (SEQ ID NO: 2363)
376_C02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2612)
	GTLVTVSS (SEQ ID NO: 2364)
376_C12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2613)
	GTLVTVSS (SEQ ID NO: 2365)
376_D05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2614)
	GTLVTVSS (SEQ ID NO: 2366)
376_D11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2615)
	GTLVTVSS (SEQ ID NO: 2367)
376_E03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2616)
	GTLVTVSS (SEQ ID NO: 2368)
376_E08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2617)
	GTLVTVSS (SEQ ID NO: 2369)
376_F03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN
	FDSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2618)
	GTLVTVSS (SEQ ID NO: 2370)
376_F04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2619)
	GTLVTVSS (SEQ ID NO: 2371)
376_G08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2620)
	GTLVTVSS (SEQ ID NO: 2372)
376_G09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISYYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2621)
	GTLVTVSS (SEQ ID NO: 2373)
376_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSDYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYYVSNLPSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2622)
	GTLVTVSS (SEQ ID NO: 2374)
376_H10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSANWHDTALDYWGQ	KVEIK (SEQ ID NO: 2623)
	GTLVTVSS (SEQ ID NO: 2375)

Table 3E provides the amino acid sequences of the CDRs of the antibodies shown in Table 2E.

TABLE 3E
CDR sequences for Group V antibodies
Ab	HCDR1	HCDR2	HCDR3	LCDR1	LCDR2	LCDR3
365_A03	SSYSMN	WVAGINYNSGYKG	ARSANWHDTALD	LSYLNWY	LVIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2624)	NO: 2872)	NO: 3120)	NO: 3368)	NO: 3616)	NO: 3864)
365_A11	DDYGMN	WVSGINYNSGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSLA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2625)	NO: 2873)	NO: 3121)	NO: 3369)	NO: 3617)	NO: 3865)
365_A12	SSYGMH	WVAGINYNGGYTS	AKSANWHDTHLD	LTYVNWY	LLIYAATSRH	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2626)	NO: 2874)	NO: 3122)	NO: 3370)	NO: 3618)	NO: 3866)
365_B01	DSYGMH	WVASINYNSGYTS	ARSANWHDTALD	SSYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2627)	NO: 2875)	NO: 3123)	NO: 3371)	NO: 3619)	NO: 3867)
365_B06	DSYGMH	WVSNINYNGGYKS	ARSANWHDTALD	LTYVNWY	LLIYATTSLA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2628)	NO: 2876)	NO: 3124)	NO: 3372)	NO: 3620)	NO: 3868)
365_B07	SSYGMH	WVASINYNSGYTS	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2629)	NO: 2877)	NO: 3125)	NO: 3373)	NO: 3621)	NO: 3869)
365_B11	SSYGMH	WVAGINYNGGYTS	ARSABWGDTALD	ISYLNWY	LVIYATTSRH	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2630)	NO: 2878)	NO: 3126)	NO: 3374)	NO: 3622)	NO: 3870)
365_C01	DSYGMN	WVSSINYNSGYKS	ARSANWHDTHLD	VSYLNWY	LVIYAVTSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2631)	NO: 2879)	NO: 3127)	NO: 3375)	NO: 3623)	NO: 3871)
365_C10	SSYGMH	WVASINYNGGYTS	ARSANWHDTALD	LSYVNWY	LLIYAATSLA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2632)	NO: 2880)	NO: 3128)	NO: 3376)	NO: 3624)	NO: 3872)
365_C11	SSYSMN	WVAGINYNGGYKS	ARSANWHDTHLD	ITYLNWY	LVIYAVTSRA	QQSYSLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2633)	NO: 2881)	NO: 3129)	NO: 3377)	NO: 3625)	NO: 3873)
365_C12	SSYGMN	WVAGINYNSGYKS	ARSANWHDTALD	VSYVNWY	LVIYAVTSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2634)	NO: 2882)	NO: 3130)	NO: 3378)	NO: 2626)	NO: 3874)
365_D09	SSYGMH	WVSGINYNSGYTS	ARSANWHDTALD	LSYLNWY	LLIYAATSRA	QQSDESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2635)	NO: 2883)	NO: 3131)	NO: 3379)	NO: 3627)	NO: 3875)
365_D11	DSYGMN	WVSNINYNSGYTS	ARSANWHDTALD	VSYLNWY	LVIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2636)	NO: 2884)	NO: 3132)	NO: 3380)	NO: 3628)	NO: 3876)
365_D12	DSYGMN	WVSNINYNGGYTG	ARSANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2637)	NO: 2885)	NO: 3133)	NO: 3381)	NO: 3629)	NO: 3877)
365_E01	SDYSMN	WVSGINYNSGYKG	ARSANWHDTALD	ISYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2638)	NO: 2886)	NO: 3134)	NO: 3382)	NO: 3630)	NO: 3878)
365_E05	SSYGMH	WVAGINYNGGYTS	ARSANWHDTALD	VSYVNWY	LLIYAATSLA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2639)	NO: 2887)	NO: 3135)	NO: 3383)	NO: 3631)	NO: 3879)
365_E07	DSYGMH	WVSGINYNSGYTS	AKSANWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2640)	NO: 2888)	NO: 3136)	NO: 3384)	NO: 3632)	NO: 3880)
365_E09	SSYGMH	WVASINYNSGYKS	ARSANWHDTALD	LTYVNWY	LVIYAATSRA	QQSDDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2641)	NO: 2889)	NO: 3137)	NO: 3385)	NO: 3633)	NO: 3881)
365_F01	DSYSMN	WVSGINYNSGYKG	ARSANWHDTHLD	VSYLNWY	LVIYAATSLA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2642)	NO: 2890)	NO: 3138)	NO: 3386)	NO: 3634)	NO: 3882)
365_F06	SSYGMN	WVAGINYNSGYKS	ARSANWHDTALD	LSYVNWY	LLIYAATSRA	QQSDNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2643)	NO: 2891)	NO: 3139)	NO: 3387)	NO: 3635)	NO: 3883)
365_F12	SDYSMN	WVSGINYNGGYTS	ARSANWHDTHLD	LTYVNWY	LVIYAATSRH	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2644)	NO: 2892)	NO: 3140)	NO: 3388)	NO: 3636)	NO: 3884)
365_G01	DSYGMN	WVAGINYNSGYKS	ARSANWHDTALD	LTYVNWY	LLIYATTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2645)	NO: 2893)	NO: 3141)	NO: 3389)	NO: 3637)	NO: 3885)
365_G11	SSYGMN	WVANINYNGGYTG	ARSANWHDTALD	ITYVNWY	LLIYAVTSRH	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2646)	NO: 2894)	NO: 3142)	NO: 3390)	NO: 3638)	NO: 3886)
365_H02	SDYGMN	WVSSINYNGGYTG	ARSANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2647)	NO: 2895)	NO: 3143)	NO: 3391)	NO: 3639)	NO: 3887)
365_H03	DDYGMN	WVAGINYNGGYKS	ARSANWHDTALD	LSYVNWY	LVIYAATSLH	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2648)	NO: 2896)	NO: 3144)	NO: 3392)	NO: 3640)	NO: 3888)
365_H06	SSYGMN	WVSGINYNSGYTG	ARSANWHDTALD	SSYVNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2649)	NO: 2897)	NO: 3145)	NO: 3393)	NO: 3641)	NO: 3889)
365_H10	DSYGMN	WVAGINYNSGYKS	ARSANWHDTHLD	VTYVNWY	LVIYAATSLA	QQSYNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2650)	NO: 2898)	NO: 3146)	NO: 3394)	NO: 3642)	NO: 3890)
365_H11	SSYSMN	WVSGINYNSGYTG	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2651)	NO: 2899)	NO: 3147)	NO: 3395)	NO: 3643)	NO: 3891)
365_H12	SSYSMN	WVSNINYNGGYKS	ARSANWHDTHLD	ITYVNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2652)	NO: 2900)	NO: 3148)	NO: 3396)	NO: 3644)	NO: 3892)
366_A07	SSYGMH	WVASINYNGGYTG	ARSANWHDTALD	VSYVNWY	LVIYAATSRH	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2653)	NO: 2901)	NO: 3149)	NO: 3397)	NO: 3645)	NO: 3893)
366_B08	DSYGMN	WVSNINYNGGYKG	ARSANWHDTHLD	VSYLNWY	LLIYAATSRH	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2654)	NO: 2902)	NO: 3150)	NO: 3398)	NO: 3646)	NO: 3894)
366_B10	SSYGMN	WVSGINYNSGYTS	ARSANWHDTALD	ISYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2655)	NO: 2903)	NO: 3151)	NO: 3399)	NO: 3647)	NO: 3895)
366_B12	SSYSMN	WVAGINYNSGYKG	ARSANWHDTALD	LTYVNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2656)	NO: 2904)	NO: 3152)	NO: 3400)	NO: 3648)	NO: 3896)
366_D04	SSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	SSYVNWY	LLIYATTSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2657)	NO: 2905)	NO: 3153)	NO: 3401)	NO: 3649)	NO: 3897)
366_E10	DSYGMN	WVSGINYNGGYKG	ARSANWHDTHLD	LSYVNWY	LVIYAATSRH	QQSYSLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2658)	NO: 2906)	NO: 3154)	NO: 3402)	NO: 3650)	NO: 3898)
366_F04	SDYGMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYVNWY	LVIYATTSRH	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2659)	NO: 2907)	NO: 3155)	NO: 3403)	NO: 3651)	NO: 3899)
366_F05	SSYSMN	WVANINYNSGYKS	ARSANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSDNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2660)	NO: 2908)	NO: 3156)	NO: 3404)	NO: 3652)	NO: 3900)
366_F07	SDYSMN	WVAGINYNSGYTS	ARSANWHDTHLD	ITYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2661)	NO: 2909)	NO: 3157)	NO: 3405)	NO: 3653)	NO: 3901)
366_G04	SSYSMN	WVSGINYNSGYTS	ARSANWHDTALD	ITYLNWY	LLIYAATSRA	QQSDDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2662)	NO: 2910)	NO: 3158)	NO: 3406)	NO: 3654)	NO: 3902)
366_G05	DSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	ISYVNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2663)	NO: 2911)	NO: 3159)	NO: 3407)	NO: 3655)	NO: 3903)
366_H06	SSYGMN	WVSSINYNGGYTG	ARSANWHDTALD	LSYLNWY	LLIYATTSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2664)	NO: 2912)	NO: 3160)	NO: 3408)	NO: 3656)	NO: 3904)
366_H07	SSYGMH	WVSGINYNGGYTS	ARSANWHDTALD	ISYVNWY	LVIYAVTSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2665)	NO: 2913)	NO: 3161)	NO: 3409)	NO: 3657)	NO: 3905)
366_H08	SDYGMN	WVASINYNSGYTS	ARSANWHDTHLD	LSYVNWY	LLIYAATSRH	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2666)	NO: 2914)	NO: 3162)	NO: 3410)	NO: 3658)	NO: 3906)
366_H09	DSYGMN	WVSNINYNSGYKG	ARSANWHDTALD	VSYVNWY	LVIYATTSRA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2667)	NO: 2915)	NO: 3163)	NO: 3411)	NO: 3659)	NO: 3907)
367_A04	SSYSMN	WVSNINYNSGYKS	ARSANWHDTALD	ITYLNWY	LLIYAATSRA	QQSDDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2668)	NO: 2916)	NO: 3164)	NO: 3412)	NO: 3660)	NO: 3908)
367_A05	SDYGMN	WVSSINYNGGYKG	ARSANWHDTALD	LSYLNWY	LVIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2669)	NO: 2917)	NO: 3165)	NO: 3413)	NO: 3661)	NO: 3909)
367_B02	DSYGMN	WVSSINYNGGYTS	ARSANWHDTALD	VTYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2670)	NO: 2918)	NO: 3166)	NO: 3414)	NO: 3662)	NO: 3910)
367_B03	SSYGMN	WVAGINYNGGYKS	ARSANWHDTALD	LTYLNWY	LLIYAATSLA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2671)	NO: 2919)	NO: 3167)	NO: 3415)	NO: 3663)	NO: 3911)
367_B07	SDYSMN	WVAGINYNSGYTG	ARSANWHDTHLD	ISYVNWY	LLIYAATSLA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2672)	NO: 2920)	NO: 3168)	NO: 3416)	NO: 3664)	NO: 3912)
367_B08	SDYGMN	WVSGINYNGGYKG	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2673)	NO: 2921)	NO: 3169)	NO: 3417)	NO: 3665)	NO: 3913)
367_C01	DDYSMN	WVSGINYNGGYKS	ARSANWHDTHLD	LTYLNWY	LVIYATTSLH	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2674)	NO: 2922)	NO: 3170)	NO: 3418)	NO: 3666)	NO: 3914)
367_C05	DDYGMN	WVSSINYNGGYTG	ARSANWHDTHLD	LSYVNWY	LVIYAATSRH	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2675)	NO: 2923)	NO: 3171)	NO: 3419)	NO: 3667)	NO: 3915)
367_C11	DSYSMN	WVSSINYNSGYTG	ARSANWHDTHLD	LSYLNWY	LVIYAATSRH	QQSYNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2676)	NO: 2924)	NO: 3172)	NO: 3420)	NO: 3668)	NO: 3916)
367_D10	DSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	ISYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2677)	NO: 2925)	NO: 3173)	NO: 3421)	NO: 3669)	NO: 3917)
367_E01	SSYGMN	WVAGINYNGGYKS	ARSANWHDTALD	LSYVNWY	LLIYTTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2678)	NO: 2926)	NO: 3174)	NO: 3422)	NO: 3670)	NO: 3918)
367_E04	SDYSMN	WVSSINYNGGYKG	ARSANWHDTHLD	LSYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2679)	NO: 2927)	NO: 3175)	NO: 3423)	NO: 3671)	NO: 3919)
367_E06	DSYSMN	WVSSINYNSGYKG	ARSANWHDTHLD	SYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2680)	NO: 2928)	NO: 3176)	NO: 3424)	NO: 3672)	NO: 3920)
367_E09	SDYGMN	WVASINYNSGYKG	ARSANWHDTALD	LSYLNWY	LVIYATTSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2681)	NO: 2929)	NO: 3177)	NO: 3425)	NO: 3673)	NO: 3921)
367_E11	DSYGMN	WVSSINYNSGYKG	ARSANWHDTHLD	VSYVNWY	LVIYAATSRH	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2682)	NO: 2930)	NO: 3178)	NO: 3426)	NO: 3674)	NO: 3922)
367_F03	SSYSMN	WVAGINYNSGYKS	ARSANWHDTALD	LSYVNWY	LVIYAATSLA	QQSDDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2683)	NO: 2931)	NO: 3179)	NO: 3427)	NO: 3675)	NO: 3923)
367_F07	DSYGMH	WVANINYNGGYTG	ARSANWHDTALD	ISYVNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2684)	NO: 2932)	NO: 3180)	NO: 3428)	NO: 3676)	NO: 3924)
367_F11	SSYSMN	WVAGINYNSGYTG	ARSANWHDTHLD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2685)	NO: 2933)	NO: 3181)	NO: 3429)	NO: 3677)	NO: 3925)
367_G05	SDYGMN	WVANINYNGGYTS	ARSANWHDTALD	VSYLNWY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2686)	NO: 2934)	NO: 3182)	NO: 3430)	NO: 3678)	NO: 3926)
367_G06	SSYGMN	WVSGINYNSGYKS	ARSANWHDTHLD	LTYVNWY	LLIYATTSLH	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2687)	NO: 2935)	NO: 3183)	NO: 3431)	NO: 3679)	NO: 3927)
367_G10	DDYGMN	WVSGINYNGGYTS	ARSANWHDTALD	ISYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2688)	NO: 2936)	NO: 3184)	NO: 3432)	NO: 3680)	NO: 3928)
367_H06	SSYGMN	WVSNINYNGGYTG	ARSANWHDTHLD	ITYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2689)	NO: 2937)	NO: 3185)	NO: 3433)	NO: 3681)	NO: 3929)
367_H11	SSYGMN	WVAINYNGGYKG	ARSANWHDTALD	ISYVNWY	LVIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2690)	NO: 2938)	NO: 3186)	NO: 3434)	NO: 3682)	NO: 3930)
368_A01	SSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	ISYLNWY	LLIYAATSRH	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2691)	NO: 2939)	NO: 3187)	NO: 3435)	NO: 3683)	NO: 3931)
368_A05	SSYSMN	WVAGINYNSGYTG	ARSANWHDTALD	VSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2692)	NO: 2940)	NO: 3188)	NO: 3436)	NO: 3684)	NO: 3932)
368_A07	SSYSMN	WVAGINYNSGYTS	ARSANWHDTHLD	LTYLNWY	LVIYATTSRA	QQSNELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2693)	NO: 2941)	NO: 3189)	NO: 3437)	NO: 3685)	NO: 3933)
368_A09	DSYSMN	WVSGINYNGGYTS	ARSANWHDTHLD	LSYVNWY	LLIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2694)	NO: 2942)	NO: 3190)	NO: 3438)	NO: 3686)	NO: 3934)
368_B01	SSYGMN	WVSGINYNSGYKS	ARSANWHDTALD	SSYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2695)	NO: 2943)	NO: 3191)	NO: 3439)	NO: 3687)	NO: 3935)
368_B06	DSYGMH	WVSGINYNSGYTS	ARSANWHDTALD	ISYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2696)	NO: 2944)	NO: 3192)	NO: 3440)	NO: 3688)	NO: 3936)
368_B07	SDYSMN	WVSNINYNGGYKS	ARSANWHDTALD	VSYLNWY	LLIYAATSLA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2697)	NO: 2945)	NO: 3193)	NO: 3441)	NO: 3689)	NO: 3937)
368_C05	DSYGMN	WVSGINYNSGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSDSNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2698)	NO: 2946)	NO: 3194)	NO: 3442)	NO: 3690)	NO: 3938)
368_D01	SSYGMH	WVANINYNGGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSDSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2699)	NO: 2947)	NO: 3195)	NO: 3443)	NO: 3691)	NO: 3939)
368_D04	SSYGMN	WVSGINYNGGYKS	ARSANWHDTALD	STYVNWY	LVIYAVTSRH	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2700)	NO: 2948)	NO: 3196)	NO: 3444)	NO: 3692)	NO: 3940)
368_D05	SSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSDDPSL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2701)	NO: 2949)	NO: 3197)	NO: 3445)	NO: 3693)	NO: 3941)
368_D11	SSYGMN	WVSNINYNGGYKS	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2702)	NO: 2950)	NO: 3198)	NO: 3446)	NO: 3694)	NO: 3942)
368_E01	SSYSMN	WVASINYNSGYTG	ARSANWHDTHLD	LSYLNWY	LVIYAVTSRH	QQSYSLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2703)	NO: 2951)	NO: 3199)	NO: 3447)	NO: 3695)	NO: 3943)
368_E02	DSYSMN	WVAGINYNSGYTS	ARSANWHDTHLD	LTYLNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2704)	NO: 2952)	NO: 3200)	NO: 3448)	NO: 3696)	NO: 3944)
368_E04	SSYSMN	WVANINYNSGYTG	ARSANWHDTALD	LSYVNWY	LLIYAATSRH	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2705)	NO: 2953)	NO: 3201)	NO: 3449)	NO: 3697)	NO: 3945)
368_E06	SDYGMH	WVSGINYNGGYTG	ARSANWHDTALD	LSYLNWY	LVIYGATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2706)	NO: 2954)	NO: 3202)	NO: 3450)	NO: 3698)	NO: 3946)
368_E07	SSYGMN	WVAGINYNGGYTS	AKSANWHDTALD	LSYLNWY	LLIYAVTSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2707)	NO: 2955)	NO: 3203)	NO: 3451)	NO: 3699)	NO: 3947)
368_F03	DSYSMN	WVAGINYNSGYTG	AKSANWHDTALD	ISYLNWY	LVIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2708)	NO: 2956)	NO: 3204)	NO: 3452)	NO: 3700)	NO: 3948)
368_F11	SDYGMN	WVSGINYNGGYTS	ARSANWHDTHLD	VWYVNWY	LVIYAATSRA	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2709)	NO: 2957)	NO: 3205)	NO: 3453)	NO: 3701)	NO: 3949)
368_G01	SDYGMH	WVASINYNSGYTS	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2710)	NO: 2959)	NO: 3206)	NO: 3454)	NO: 3702)	NO: 3950)
368_G12	SSYGMN	WVASINYNSGYTG	ARSANWHDTALD	SSYVNWY	LVIYAVTSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2711)	NO: 2959)	NO: 3207)	NO: 3455)	NO: 3703)	NO: 3951)
368_H04	SSYSMN	WVAGINYNSGYKG	AKSANWHDTHLD	VSYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2712)	NO: 2960)	NO: 3208)	NO: 3456)	NO: 3704)	NO: 3952)
369_A02	SSYSMN	WVAGINYNSGYTG	ARSANWHDTHLD	LSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2713)	NO: 2961)	NO: 3209)	NO: 3457)	NO: 3705)	NO: 3953)
369_A03	SSYGMN	WVSNINYNGGYTG	ARSANWHDTALD	LTYLNWY	LLIYAVTSRH	QQGYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2714)	NO: 2962)	NO: 3210)	NO: 3458)	NO: 3706)	NO: 3954)
369_B01	SSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYLNWY	LLIYAVTSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2715)	NO: 2963)	NO: 3211)	NO: 3459)	NO: 3707)	NO: 3955)
369_B01	DSYSMN	WVSNINYNGGYKS	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2716)	NO: 2964)	NO: 3212)	NO: 3460)	NO: 3708)	NO: 3956)
369_C03	SSYGMN	WVSNINYNGGYKS	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2717)	NO: 2965)	NO: 3213)	NO: 3461)	NO: 3709)	NO: 3957)
369_C04	SSYSMN	WVSNINYNGGYTG	ARSANWHDTALD	LTYVNWY	LLIYTTTSLH	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2718)	NO: 2966)	NO: 3214)	NO: 3462)	NO: 3710)	NO: 3958)
369_D01	SDYGMN	WVASINYNGGYTG	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYSNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2719)	NO: 2967)	NO: 3215)	NO: 3463)	NO: 3711)	NO: 3959)
369_D02	SDYSMN	WVSNINYNSGYTG	ARSANWHDTALD	LSYLNWY	LVIYAVTSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2720)	NO: 2968)	NO: 3216)	NO: 3464)	NO: 3712)	NO: 3960)
369_D04	DSYGMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2721)	NO: 2969)	NO: 3217)	NO: 3465)	NO: 3713)	NO: 3961)
369_D12	DSYSMN	WVAGINYNSGYTS	ARSANWHDTALD	LSYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2722)	NO: 2970)	NO: 3218)	NO: 3466)	NO: 3714)	NO: 3962)
369_E02	DSYGMN	WVSNINYNGGYTG	ARSANWHDTALD	VSYVNWY	LLIYATTSRH	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2723)	NO: 2971)	NO: 3219)	NO: 3467)	NO: 3715)	NO: 3963)
369_E11	SSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	ISYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2724)	NO: 2972)	NO: 3220)	NO: 3468)	NO: 3716)	NO: 3964)
369_E12	SSYGMH	WVASINYNSGYTS	ARSANWHDTALD	ISYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2725)	NO: 2973)	NO: 3221)	NO: 3469)	NO: 3717)	NO: 3965)
369_F01	SSYGMN	WVSGINYNGGYKS	ARSANWHDTALD	LTYVNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2726)	NO: 2974)	NO: 3222)	NO: 3470)	NO: 3718)	NO: 3966)
369_F02	SSYGMN	WVASINYNSGYKS	ARSANWHDTALD	VSYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2727)	NO: 2975)	NO: 3223)	NO: 3471)	NO: 3719)	NO: 3967)
369_F03	SSYGMN	WVSGINYNSGYTS	ARSANWHDTALD	VSYVNWY	LVIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2728)	NO: 2976)	NO: 3224)	NO: 3472)	NO: 3720)	NO: 3968)
369_F06	DDYSMN	WVAGINYNGGYKG	ARSANWHDTALD	VSYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2729)	NO: 2977)	NO: 3225)	NO: 3473)	NO: 3721)	NO: 3969)
369_F10	DSYGMN	WVSNINYNSGYKS	ARSANWHDTALD	VTYLNWY	LLIYAVTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2730)	NO: 2978)	NO: 3226)	NO: 3474)	NO: 3722)	NO: 3970)
369_F11	DSYGMN	WVSNINYNSGYKS	ARSANWHDTALD	ISYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2731)	NO: 2979)	NO: 3227)	NO: 3475)	NO: 3723)	NO: 3971)
369_G01	SSYSMN	WVSNINYNSGYKS	ARSANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2732)	NO: 2980)	NO: 3228)	NO: 3476)	NO: 3724)	NO: 3972)
369_G04	DSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LTYVNWY	LLIYATTSRH	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2733)	NO: 2981)	NO: 3229)	NO: 3477)	NO: 3725)	NO: 3973)
369_G06	DSYGMN	WVAGINYNGGYTS	ARSANWHDTALD	LYSVNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2734)	NO: 2982)	NO: 3230)	NO: 3478)	NO: 3726)	NO: 3974)
369_G11	SSYSMN	WVANINYNSGYKG	ARSANWHDTALD	LTYLNWY	LLIYAATSLA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2735)	NO: 2983)	NO: 3231)	NO: 3479)	NO: 3727)	NO: 3975)
369_G12	SSYSMN	WVANINYNGGYTG	ARSANWHDTALD	LTYVNWY	LVIYAATSRH	QQSDNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2736)	NO: 2984)	NO: 3232)	NO: 3480)	NO: 3728)	NO: 3976)
369_H05	SSYGMN	WVANINYNGGYTG	ARSANWHDTALD	VSYVNWY	LLIYAATSRA	QQSYSNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2737)	NO: 2985)	NO: 3233)	NO: 3481)	NO: 3729)	NO: 3977)
369_H06	SSYGMN	WVANINYNGGYKS	ARSANWHDTALD	VSYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2738)	NO: 2986)	NO: 3234)	NO: 3482)	NO: 3730)	NO: 3978)
369_H09	DDYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYVNWY	LLIYAVTSLA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2739)	NO: 2987)	NO: 3235)	NO: 3483)	NO: 3731)	NO: 3979)
370_A01	SSYSMN	WVSGINYNSGYKS	ARSANWHDTALD	STYLNWY	LVIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2740)	NO: 2988)	NO: 3236)	NO: 3484)	NO: 3732)	NO: 3980)
370_A03	SSYSMN	WVSNINYNGGYTS	ARSANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2741)	NO: 2989)	NO: 3237)	NO: 3485)	NO: 3733)	NO: 3981)
370_A04	DSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	ITYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2742)	NO: 2990)	NO: 3238)	NO: 3486)	NO: 3734)	NO: 3982)
370_A12	SSYGMN	WVAGINYNGGYTS	ARSANWHDTALD	LTYLNWY	LLIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2743)	NO: 2991)	NO: 3239)	NO: 3487)	NO: 3735)	NO: 3983)
370_C01	DSYSMN	WVSGINYNSGYTG	ARSANWHDTALD	LTYLNWY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2744)	NO: 2992)	NO: 3240)	NO: 3488)	NO: 3736)	NO: 3984)
370_C03	SSYGMN	WVAGINYNGGYKG	ARSANWHDTALD	LTYLNWY	LLIYYVTNRQ	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2745)	NO: 2993)	NO: 3241)	NO: 3489)	NO: 3737)	NO: 3985)
370_C05	SSYSMN	WVAGINYNSGYTG	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2746)	NO: 2994)	NO: 3242)	NO: 3490)	NO: 3738)	NO: 3986)
370_C08	SSYGMN	WVAGINYNGGYKG	ARSANWHDTALD	SNYLNWY	LLIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2747)	NO: 2995)	NO: 3243)	NO: 3491)	NO: 3739)	NO: 3987)
370_C09	DSYGMN	WVSGINYNGGYTS	ARSANWHDTALD	ISYLNWY	LVIYAATSLA	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2748)	NO: 2996)	NO: 3244)	NO: 3492)	NO: 3740)	NO: 3988)
370_D04	DSYSMN	WVANINYNSGYKG	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2749)	NO: 2997)	NO: 3245)	NO: 3493)	NO: 3741)	NO: 3989)
370_D11	DSYSMN	WVSGINYNGGYTG	ARSANWHDTALD	VSYLNWY	LLIYAASTRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2750)	NO: 2998)	NO: 3246)	NO: 3494)	NO: 3742)	NO: 3990)
370_E03	SSYGMN	WVSSINYNGGYKG	ARSANWHDTALD	LTYLNWY	LVIYYASNRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2751)	NO: 2999)	NO: 3247)	NO: 3495)	NO: 3743)	NO: 3991)
370_E06	SSYGMN	WVSGINYNSGYKS	ARSANWHDTALD	LSYLNWY	LVIYATTSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2752)	NO: 3000)	NO: 3248)	NO: 3496)	NO: 3744)	NO: 3992)
370_E09	DDSSMH	WVSNINYNGGYTG	AKSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2753)	NO: 3001)	NO: 3249)	NO: 3497)	NO: 3745)	NO: 3993)
370_F05	SSYGMN	WVSGINYNSGYTS	ARSANWHDTALD	VSYVNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2754)	NO: 3002)	NO: 3250)	NO: 3498)	NO: 3746)	NO: 3994)
370_F07	DSYSMN	WVSNINYNGGYKG	ARSANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2755)	NO: 3003)	NO: 3251)	NO: 3499)	NO: 3747)	NO: 3995)
370_F10	SSYSMN	WVAGINYNGGYTS	ARSANWHDTALD	VSYLNWY	LVIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2756)	NO: 3004)	NO: 3252)	NO: 3500)	NO: 3748)	NO: 3996)
370_G02	SDYSMN	WVANINYNGGYKG	ARSANWHDTALD	VSYLNWY	LLIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2757)	NO: 3005)	NO: 3253)	NO: 3501)	NO: 3749)	NO: 3997)
370_G03	SSYSMN	WVANINYNGGYTG	ARSANWHDTALD	LTYVNWY	LVIYATTSRA	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2758)	NO: 3006)	NO: 3254)	NO: 3502)	NO: 3750)	NO: 3998)
370_G06	SDYGMH	WVSSINYNGGYTS	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSDNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2759)	NO: 3007)	NO: 3255)	NO: 3503)	NO: 3751)	NO: 3999)
370_G09	SSYGMN	WVAGINYNGGYKS	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2760)	NO: 3008)	NO: 3256)	NO: 3504)	NO: 3752)	NO: 4000)
370_G10	SDYGMN	WVSGINYNSGYTS	ARSANWHDTALD	SSYLNWY	LLIYVVNNRA	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2761)	NO: 3009)	NO: 3257)	NO: 3505)	NO: 3753)	NO: 4001)
370_G11	SSYSMN	WVASINYNSGYTS	ARSANWHDTHLD	VSYLNWY	LVIYAATSRA	QQSYSLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2762)	NO: 3010)	NO: 3258)	NO: 3506)	NO: 3754)	NO: 4002)
370_H01	SSYSMN	WVSGINYNSGYKG	ARSANWHDTALD	ISYLNWY	LLIYAVTSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2763)	NO: 3011)	NO: 3259)	NO: 3607)	NO: 3755)	NO: 4003)
370_H09	SSYGMN	WVANINYNGGYTS	ARSANWHDTALD	VSYVNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2764)	NO: 3012)	NO: 3260)	NO: 3508)	NO: 3756)	NO: 4004)
371_A03	SDYGMN	WVANINYNGGYTG	ARSANWHDTALD	LSYLNWY	LVIYATTSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2765)	NO: 3013)	NO: 3261)	NO: 3509)	NO: 3757)	NO: 4005)
371_A06	SSYGMN	WVAGINYNGGYTS	ARSANWHDTALD	LTYLNWY	LVIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2766)	NO: 3014)	NO: 3262)	NO: 3510)	NO: 3758)	NO: 4006)
371_A07	SDYSMN	WVSNINYNGGYKS	ARSANWHDTALD	LSYLNWY	LVIYATTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2767)	NO: 3015)	NO: 3263)	NO: 3511)	NO: 3759)	NO: 4007)
371_A08	SSYGMH	WVSSINYNGGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2768)	NO: 3016)	NO: 3264)	NO: 3512)	NO: 3760)	NO: 4008)
371_A12	DSYSMN	WVAGINYNSGYTS	ARSANWHDTALD	LSYVNWTY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2769)	NO: 3017)	NO: 3265)	NO: 3513)	NO: 3761)	NO: 4009)
371_B06	DSYSMN	WVAGINYNGGYKS	ARSANWHDTALD	LTYVNWY	LVIYAATSRH	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2770)	NO: 3018)	NO: 3266)	NO: 3514)	NO: 3762)	NO: 4010)
371_B07	DSYSMN	WVAGINYNGGYTS	ARSANWHDTALD	LTYVNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2771)	NO: 3019)	NO: 3267)	NO: 3515)	NO: 3763)	NO: 4011)
371_C03	SSYSMN	WVSNINYNGGYKG	ARSANWHDTALD	LSYLNWY	LVIYATTSRA	QQSTSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2772)	NO: 3020)	NO: 3268)	NO: 3516)	NO: 3764)	NO: 4012)
371_D06	DDYSMN	WVAGINYNGGYTS	ARSANWHDTALD	ISYVNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2773)	NO: 3021)	NO: 3269)	NO: 3517)	NO: 3765)	NO: 4013)
371_D09	SSYSMN	WVSNINYNSGYTG	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2774)	NO: 3022)	NO: 3270)	NO: 3518)	NO: 3766)	NO: 4014)
371_F01	SSYSMN	WVAGINYNGGYTG	ARSANWHDTALD	LTYVNWY	LVIYAATSLA	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2775)	NO: 3023)	NO: 3271)	NO: 3519)	NO: 3767)	NO: 4015)
371_F04	DSYSMN	WVAGINYNSGYKG	ARSANWHDTALD	LSYLNWY	LLIYAATSRH	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2776)	NO: 3024)	NO: 3272)	NO: 3520)	NO: 3768)	NO: 4016)
371_F06	DSYSMN	WVANINYNGGYTS	ARSANWHDTALD	VSYLNWY	LVIYAATSRH	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2777)	NO: 3025)	NO: 3273)	NO: 3521)	NO: 3769)	NO: 4017)
371_F08	DDSYMN	WVSGINYNGGYTG	ARSANWHDTALD	VSYVNWY	LVIYAATSRH	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2778)	NO: 3026)	NO: 3274)	NO: 3522)	NO: 3770)	NO: 4018)
371_G05	DSYSMN	WVSGINYNSGYTG	ARSANWHDTALD	SSYLNWY	LLIYAVTSRA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2779)	NO: 3027)	NO: 3275)	NO: 3523)	NO: 3771)	NO: 4019)
371_G10	SSYSMN	WVSGINYNGGYKS	ARSANWHDTALD	SSYVNWY	LLIYAATSRH	QQDDDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2780)	NO: 3028)	NO: 3276)	NO: 3524)	NO: 3772)	NO: 4020)
371_H09	DSYSMN	WVSNINYNGGYTS	ARSANWHDTALD	LTYVNWY	LVIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2781)	NO: 3029)	NO: 3277)	NO: 3525)	NO: 3773)	NO: 4021)
372_A04	DSYSMN	WVSGINYNSGYTS	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2782)	NO: 3030)	NO: 3278)	NO: 3526)	NO: 3774)	NO: 4022)
372_B04	DSYGMN	WVANINYNGGYTS	ARSANWHDTALD	LSYVNWY	LVIYAATSLA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2783)	NO: 3031)	NO: 3279)	NO: 3527)	NO: 3775)	NO: 4023)
272_C07	SDYSMN	WVSNINYNSGYTS	ARSANWHDTHLD	LSYLNWY	LVIYAATSRH	QQSDNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2784)	NO: 3032)	NO: 3280)	NO: 3528)	NO: 3776)	NO: 4024)
372_D02	SSYGMN	WVAGINYNGGYTG	ARSANWHDTALD	LTYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2785)	NO: 3033)	NO: 3281)	NO: 3529)	NO: 3777)	NO: 4025)
372_F03	SSYGMN	WVAGINYNGGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2786)	NO: 3034)	NO: 3282)	NO: 3530)	NO: 3778)	NO: 4026)
372_F06	SDYGMN	WVAGINYNGGYKS	ARSANWHDTALD	LSYVNWY	LLIYAATSLA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2787)	NO: 3035)	NO: 3283)	NO: 3531)	NO: 3779)	NO: 4027)
372_F08	SDYSMN	WVSNINYNSGYTG	ARSANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2788)	NO: 3036)	NO: 3284)	NO: 3532)	NO: 3780)	NO: 4028)
372_F09	DSYSMN	WVANINYNSGYKG	ARSANWHDTALD	LTYLNWY	LVIYAATSLA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2789)	NO: 3037)	NO: 3285)	NO: 3533)	NO: 3781)	NO: 4029)
373_A02	DSYGMN	WVSGINYNGGYKG	ARSANWHDTALD	LSYVNWY	LVIYATTSLA	QQSYNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2790	NO: 3038)	NO: 3286)	NO: 3534)	NO: 3782)	NO: 4030)
373_A08	DSYGMN	WVSNINYNGGYTG	ARSANWHDTALD	VSYVNWY	LLIYAATSLA	QQSYSLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2791)	NO: 3039)	NO: 3287)	NO: 3535)	NO: 3783)	NO: 4031)
373_A10	SSYGMN	WVSGINYNSGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2792)	NO: 3040)	NO: 3288)	NO: 3536)	NO: 3784)	NO: 3032)
373_B04	SSYGMN	WVAGINYNSGYKG	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2793)	NO: 3041)	NO: 3289)	NO: 3537)	NO: 3785)	NO: 4033)
373_B06	SDYSMN	WVAGINYNGGYTG	ARSANWHDTALD	LTYVNWY	LVIYAATSRH	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2794)	NO: 3042)	NO: 3290)	NO: 3538)	NO: 3786)	NO: 4034)
373_B10	DSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	LSYLNWY	LLIYAATSRA	QQSTDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2795)	NO: 3043)	NO: 3292)	NO: 3539)	NO: 3787)	NO: 4035)
373_B12	DSYGMN	WVSSINYNSGYTS	ARSANWHDTALD	VSYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2796)	NO: 3044)	NO: 3292)	NO: 3540)	NO: 3788)	NO: 4036)
373_C02	DDYSMN	WVSGINYNSGYKG	ARSANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2797)	NO: 3045)	NO: 3293)	NO: 3541)	NO: 3789)	NO: 4037)
373_C04	SSYSMN	WVANINYNSGYTG	ARSANWHTALD	ISYVNWY	LVIYAVTSRA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2798)	NO: 3046)	NO: 3294)	NO: 3542)	NO: 3790)	NO: 4038)
373_C06	SSYSMN	WVAGINYNGGYTG	ARSANWHDTALD	VSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2799)	NO: 3047)	NO: 3295)	NO: 3543)	NO: 3791)	NO: 4039)
373_C08	SSYSMN	WVANINYNGGYTS	ARSANWHDTALD	ISYLNWY	LLIYAASSLQ	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2800)	NO: 3048)	NO: 3296)	NO: 3544)	NO: 3792)	NO: 4040)
373_C11	SSYSMN	WVSGINYNSGYTG	ARSANWHDTALD	LTYVNWY	LVIYAVTSRA	QSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2801)	NO: 3049)	NO: 3297)	NO: 3545)	NO: 3793)	NO: 4041)
373_D01	DSYSMN	WVSGINYNSGYKS	ARSANWHDTHLD	LSYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2802)	NO: 3050)	NO: 3298)	NO: 3546)	NO: 3794)	NO: 4042)
373_D04	DSYSMN	WVSGINYNSGYKG	ARSANWHDTALD	LSYLNWY	LLIYAATSRH	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2803)	NO: 3051)	NO: 3299)	NO: 3547)	NO: 3795)	NO: 4043)
373_D05	SSYSMN	WVSGINYNSGYKG	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2804)	NO: 3052)	NO: 3300)	NO: 3548)	NO: 3796)	NO: 4044)
373_D08	DDYSMN	WVSGINYNGGYKS	ARSANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2805)	NO: 3053)	NO: 3301)	NO: 3549)	NO: 3797)	NO: 4045)
373_D10	DSYSMN	WVSNINYNSGYKG	ARSANWHDTALD	LSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2806)	NO: 3054)	NO: 3302)	NO: 3550)	NO: 3798)	NO: 4046)
373_E01	SSYGMN	WVSGINYNGGYKG	ARSANWHDTALD	VYSVNWY	LLIYAATSRH	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2807)	NO: 3055)	NO: 3303)	NO: 3551)	NO: 3799)	NO: 4047)
373_E05	DSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	LSYVNWY	LLIYAVTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2808)	NO: 3056)	NO: 3304)	NO: 3552)	NO: 3800)	NO: 4048)
373_E07	SSYGMN	WVANINYNGGYTS	ARSANWHDTALD	LTYVNWY	LLIYAATSLA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2809)	NO: 3057)	NO: 3305)	NO: 3553)	NO: 3801)	NO: 4049)
373_E12	SSYSMN	WVANINYNGGYTG	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 3810)	NO: 3058)	NO: 3306)	NO: 3554)	NO: 3802)	NO: 4050)
373_G10	SDYGMN	WVSNINYNGGYKS	ARSANWHDTALD	VSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2811)	NO: 3059)	NO: 3307)	NO: 3555)	NO: 3803)	NO: 4051)
373_G12	SSYSMN	WVSNINYNGGYTS	ARSANWHDTALD	LSYLNWY	LLIYATTSLA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2812)	NO: 3060)	NO: 3308)	NO: 3556)	NO: 3804)	NO: 4052)
373_H01	DSYSMN	WVANINYNGGYTG	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2813)	NO: 3061)	NO: 3309)	NO: 3557)	NO: 3805)	NO: 4053)
373_H05	SDYSMN	WVANINYNGGYKG	ARSANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2814)	NO: 3062)	NO: 3310)	NO: 3558)	NO: 3806)	NO: 4054)
374_A07	SSYSMN	WVSGINYNSGYKG	ARSANWHDTALD	LSYVNWY	LLIYAVTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2815)	NO: 3063)	NO: 3311)	NO: 3559)	NO: 3807)	NO: 4055)
374_B04	SSYSMN	WVSNINYNSGYTG	ARSANWHDTALD	VSYLNWY	LLIYAVTSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2816)	NO: 3064)	NO: 3312)	NO: 3560)	NO: 3808)	NO: 4056)
374_B06	DSYSMN	WVAGINYNSGYKG	ARSANEHDTHLD	LTYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2817)	NO: 3065)	NO: 3313)	NO: 3561)	NO: 3809)	NO: 4057)
374_B12	DSYSMN	WVAGINYNGGYTG	ARSANWHDTHLD	SSYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2818)	NO: 3066)	NO: 3314)	NO: 3562)	NO: 3810)	NO: 4058)
374_C03	DSYSMN	WVSGINYNSGYTS	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2819)	NO: 3067)	NO: 3315)	NO: 3563)	NO: 3811)	NO: 4059)
374_C06	DDYSMN	WVSSINYNSGYKG	ARSANWHDTALD	LTYVNWY	LLIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2820)	NO: 3068)	NO: 3316)	NO: 3564)	NO: 3812)	NO: 4060)
374_D01	DSYSMN	WVSGINYNSGYKG	ARSANWHDTALD	ITYVNWY	LLIYAATSLA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2821)	NO: 3069)	NO: 3317)	NO: 3565)	NO: 3813)	NO: 4061)
374_D08	DSYGMN	WVSGINYNSGYTG	ARSANWHDTHLD	LTYLNWY	LLIYAATSRH	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2822)	NO: 3070)	NO: 3318)	NO: 3566)	NO: 3814)	NO: 4062)
374_E01	SSYGMN	WVAGINYNGGYTS	ARSANWHDTALD	SSYVNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2823)	NO: 3071)	NO: 3319)	NO: 3567)	NO: 3815)	NO: 4063)
374_E02	SSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYLNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2824)	NO: 3072)	NO: 3320)	NO: 3568)	NO: 3816)	NO: 4064)
374_E05	SSYSMN	WVAGINYNGGYTS	ARSANWHDTALD	LSFVNWY	LVIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2825)	NO: 3073)	NO: 3321)	NO: 3569)	NO: 3817)	NO: 4065)
374_E07	SDYSMN	WVAGINYNGGYTS	ARSANWHDTALD	ITYVNWY	LVIYAATSRA	QQSYNTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2826)	NO: 3074)	NO: 3322)	NO: 3570)	NO: 3818)	NO: 4066)
374_E08	SSYGMN	WVAGINYNGGYKS	ARSANEHDTALD	LSYLNWY	LLIYAATSRH	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2827)	NO: 3075)	NO: 3323)	NO: 3571)	NO: 3819)	NO: 4067)
374_E11	SSYGMN	WVSNINYNGGYTS	ARSANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2828)	NO: 3076)	NO: 3324)	NO: 3572)	NO: 3820)	NO: 4068)
374_F01	DSYSMN	WVSNINYNGGYTG	ARSANWHDTALD	LSYVNWY	LVIYAATSRH	QQSYENPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2829)	NO: 3077)	NO: 3325)	NO: 3573)	NO: 3821)	NO: 4069)
374_F02	DSYSMN	WVANINYNSGYTS	ARSANWHDTALD	VSYLNWY	LLIYAASSLQ	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2830	NO: 3078)	NO: 3326)	NO: 3574)	NO: 3822)	NO: 4070)
374_F04	SSYGMN	WVSGINYNSGYKS	ARSANWHDTALD	LTYVNWY	LLIYAATSRA	QQSYNSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2831)	NO: 3079)	NO: 3327)	NO: 3575)	NO: 3823)	NO: 4071)
374_F10	SSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2832)	NO: 3080)	NO: 3328)	NO: 3576)	NO: 3824)	NO: 4072)
374_F11	DSYSMN	WVSNINYNGGYTG	ARSANWHDTALD	LSYLNWY	LLIYAVTSLA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2933)	NO: 3081)	NO: 3329)	NO: 3577)	NO: 3825)	NO: 4073)
374_G04	SSYSMN	WVAGINYNGGYTG	ARSANWHDTALD	LTYLNWY	LVIYAATSLA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2834)	NO: 3082)	NO: 3330)	NO: 3578)	NO: 3826)	NO: 4074)
374_G06	SSYGMH	WVASINYNGGYTS	ARSANWHDTALD	LSYLNWY	LLIYAVTSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2835)	NO: 3083)	NO: 3331)	NO: 3579)	NO: 3827)	NO: 4075)
374_G07	SSYSMN	WVSGINYNSGYKS	ARSANWHDTALD	ISYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2836)	NO: 3084)	NO: 3332)	NO: 3580)	NO: 3828)	NO: 4076)
374_H03	SSYGMN	WVSGINYNSGYKS	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2837	NO: 3085)	NO: 3333)	NO: 3581)	NO: 3829)	NO: 4077)
374_H04	DSYSMN	WVSGINYNSGYTS	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2838	NO: 3086)	NO: 3334)	NO: 3582)	NO: 3830)	NO: 4078)
374_H06	SSYGMN	WVSNINYNGGYTG	ARSANWHDTALD	VSYVNWY	LVIYAATSRA	QQSYNLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2839)	NO: 3087)	NO: 3335)	NO: 3583)	NO: 3831)	NO: 4079)
374_H07	DSYGMN	WVANINYNGGYTG	ARSANWHDTALD	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2840)	NO: 3088)	NO: 3336)	NO: 3584)	NO: 3832)	NO: 4080)
374_H09	SSYSMN	WVANINYNSGYKS	ARSANWHDTALD	LSYLNWY	LVIYAVTSLA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2841)	NO: 3089)	NO: 3337)	NO: 3585)	NO: 3833)	NO: 4081)
375_A05	SSYGMN	WVANINYNGGYKG	ARSANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2842)	NO: 3090)	NO: 3338)	NO: 3586)	NO: 3834)	NO: 4082)
375_C06	DDYGMH	WVASINYNSGYTS	ARSANWHDTALD	LTYVNWY	LVIYATTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2843)	NO: 3091)	NO: 3339)	NO: 3587)	NO: 3835)	NO: 4083)
375_D04	DDSSMH	WVSNINYNGGYTG	AKSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2844)	NO: 3092)	NO: 3340)	NO: 3588)	NO: 3836)	NO: 4084)
375_D05	SSYSMN	WVASINYNSGYTS	ARSANWHDTHLD	VSYLNWY	LLIYAATSLH	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2845)	NO: 3093)	NO: 3341)	NO: 3589)	NO: 3837)	NO: 4085)
375_D07	SSYGMN	WVANINYNSGYTG	ARSANWHDTALD	ITYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2846)	NO: 3094)	NO: 3342)	NO: 3590)	NO: 3838)	NO: 4086)
375_D08	SDYGMN	WVSGINYNSGYKG	ARSANWHDTALD	ITYLNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2847)	NO: 3095)	NO: 3343)	NO: 3591)	NO: 3839)	NO: 4087)
375_D12	DSYGMN	WVSSINYNSGYTS	ARSANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2848)	NO: 3096)	NO: 3344)	NO: 3592)	NO: 3840)	NO: 4088)
375_E01	SSYSMN	WVSGINYNSGYKS	ARSANWHDTLAD	LTYLNWY	LVIYAATSRA	QQSDDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2849)	NO: 3097)	NO: 3345)	NO: 3593)	NO: 3841)	NO: 4089)
375_E07	SDYSMN	WVAGINYNSGYKG	ARSANWHDTALD	VTYLNWY	LLIYVVTNRE	AASYETPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2850)	NO: 3098)	NO: 3346)	NO: 3594)	NO: 3842)	NO: 4090)
375_H12	SSYGMN	WVAGINYNGGYKG	ARSANWHDTALD	LTYLNWY	LLIYYVTNRQ	QQSYSIPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2851)	NO: 3099)	NO: 3347)	NO: 3595)	NO: 3843)	NO: 4091)
376_A04	DSYSMN	WVSNINYNGGYTS	ARSANWHDTALD	VTYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2852)	NO: 3100)	NO: 3348)	NO: 3596)	NO: 3844)	NO: 4092)
376_A10	SDYGMN	WVSNINYNSGYKG	ARSANWHDTALD	LSYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2853)	NO: 3101)	NO: 3349)	NO: 3597)	NO: 3845)	NO: 4093)
376_A12	SSYSMN	WVANINYNSGYKG	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2854)	NO: 3102)	NO: 3350)	NO: 3598)	NO: 3846)	NO: 4094)
376_B04	DSYGMH	WVASINYNGGYTG	ARSANWHDTALD	VSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2855)	NO: 3103)	NO: 3351)	NO: 3599)	NO: 3847)	NO: 4095)
376_B05	SSYSMN	WVANINYNGGYTG	ARSANWHDTALD	ISYVNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2856)	NO: 3104)	NO: 3352)	NO: 3600)	NO: 3848)	NO: 4096)
376_B09	DSYSMN	WVANINYNSGYKG	ARSANWHDTALD	LTYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2857)	NO: 3105)	NO: 3353)	NO: 3601)	NO: 3849)	NO: 4097)
376_B11	SSYSMN	WVSGINYNGGYTS	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2858)	NO: 3106)	NO: 3354)	NO: 3602)	NO: 3850)	NO: 4098)
376_C01	DSYSMN	WVAGINYNGGYTS	ARSANWHDTALD	LTYLNWY	LLIYAATSLA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2859)	NO: 3107)	NO: 3355)	NO: 3603)	NO: 3851)	NO: 4099)
376_C02	DSYGMN	WVSGINYNSGYTS	ARSANWHDTALD	VSYLNWY	LVIYAVTSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2860)	NO: 3108)	NO: 3356)	NO: 3604)	NO: 3852)	NO: 4100)
376_C12	SSYSMN	WVAGINYNGGYTG	ARSANWHDTALD	LTYVNWY	LLIYAATSRA	QQDYSDPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2861)	NO: 3109)	NO: 3357)	NO: 3605)	NO: 3853)	NO: 4101)
376_D05	SSYSMN	WVSNINYNGGYKG	ARSANWHDTALD	VSYVNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2862)	NO: 3110)	NO: 3358)	NO: 3606)	NO: 3854)	NO: 4102)
376_D11	SSYGMN	WVANINYNGGYTG	ARSANWHDTALD	LSYLNWY	LVIYAATSRA	QQSYNNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2863)	NO: 3111)	NO: 3359)	NO: 3607)	NO: 3855)	NO: 4103)
376_E03	SSYGMN	WVANINYNGGYTG	ARSANWHDTALD	LSYVNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2864)	NO: 3112)	NO: 3360)	NO: 3608)	NO: 3856)	NO: 4101)
376_E08	SDYGMN	WVAGININGGYTS	ARSANWHDTALD	VSYVNWY	LVIYAATSRA	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2865)	NO: 3113)	NO: 3361)	NO: 3609)	NO: 3857)	NO: 4105)
376_F03	DSYGMN	WVANINYNGGYTG	ARSANWHDTALD	ITYVNWY	LVIYATTLSA	QQSYSSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2866)	NO: 3114)	NO: 3362)	NO: 3610)	NO: 3858)	NO: 4106)
376_F04	DSYSMN	WVSNINYNSGYTG	ARSANWHDTALD	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2867)	NO: 3115)	NO: 3363)	NO: 3611)	NO: 3859)	NO: 4107)
376_G08	DSYGMN	WVANINYNGGYTS	ARSANWHDTALD	LSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2868)	NO: 3116)	NO: 3364)	NO: 3612)	NO: 3860)	NO: 4108)
376_G09	DAYSMN	WVSGINYNSGYKG	ARSANWHDTALD	SYYLNWY	LLIYAVTSRA	QQSYDNPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2869)	NO: 3117)	NO: 3365)	NO: 3613)	NO: 3861)	NO: 4109)
376_H09	SDYSMN	WVANINYNGGYTG	ARSANWHDTALD	ITYLNWY	LVIYYVSNLP	QQSYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2870)	NO: 3118)	NO: 3366)	NO: 3614)	NO: 3862)	NO: 4110)
376_H10	DSYSMN	WVSGINYNSGYKS	ARSANWHDTALD	LTYLNWY	LVIYAATSRH	QQDYDSPL
	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 2871)	NO: 3119)	NO: 3367)	NO: 3615)	NO: 3863)	NO: 4111)

The consensus sequences for each of these CDRs shown in FIG. 3E are as follows:

HCDR1:
(SEQ ID NO: 6578)
S/DS/DYG/SMN/H
HCDR2:
(SEQ ID NO: 6579)
WVS/AG/N/SINYNG/SGYT/KS/G
HCDR3:
(SEQ ID NO: 6597)
AR/KSANWHDTA/HLD
LCDR1:
(SEQ ID NO: 6561)
L/V/I/SS/TYLNNWY
LCDR2:
(SEQ ID NO: 6582)
LL/VIYA/YA/V/TT/SS/NR/LA/H/Q
LCDR3:
(SEQ ID NO: 6598)
QQSY/DD/E/N/SS/T/L/NPL

TABLE 2F
Group IV Antibody Sequences
Ab	VH sequence	VL sequence
365_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCAKSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4281)
	GTLVTVSS (SEQ ID NO: 4112)
370_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4282)
	GTLVTVSS (SEQ ID NO: 4113)
368_C01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FDSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4283)
	GTLVTVSS (SEQ ID NO: 4114)
376_C06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4284)
	GTLVTVSS (SEQ ID NO: 4115)
368_D10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4285)
	GTLVTVSS (SEQ ID NO: 4116)
365_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4286)
	GTLVTVSS (SEQ ID NO: 4117)
367_C03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4287)
	GTLVTVSS (SEQ ID NO: 4118)
367_H07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYATTSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4288)
	GTLVTVSS (SEQ ID NO: 4119)
371_D03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4289)
	GTLVTVSS (SEQ ID NO: 4120)
369_C10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDSLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4290)
	GTLVTVSS (SEQ ID NO: 4121)
367_F05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4291)
	GTLVTVSS (SEQ ID NO: 4122)
365_C07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYGMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4292)
	GTLVTVSS (SEQ ID NO: 4123)
374_C08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4293)
	GTLVTVSS (SEQ ID NO: 4124)
376_A06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYYVSNRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4294)
	GTLVTVSS (SEQ ID NO: 4125)
376_B07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYYVSNRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4295)
	GTLVTVSS (SEQ ID NO: 4126)
365_F07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4296)
	GTLVTVSS (SEQ ID NO: 4127)
369_E10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4297)
	GTLVTVSS (SEQ ID NO: 4128)
373_E03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTALDYWGQ	KVEIK (SEQ ID NO: 4298)
	GTLVTVSS (SEQ ID NO: 4129)
366_B04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4299)
	GTLVTVSS (SEQ ID NO: 4130)
376_F12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDDYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4300)
	GTLVTVSS (SEQ ID NO: 4131)
369_F07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4301)
	GTLVTVSS (SEQ ID NO: 4132)	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
368_C06	EVQLLESGGGLVQPGGSLRLSCAASGFT	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	YKSYADSVKGRFTISRDNSKNTLYLQMN	KVEIK (SEQ ID NO: 4302)
	SLRAEDTAVYYCARSATWHDTHLDYWGQ
	GTLVTVSS (SEQ ID NO: 4133)
376_E12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4303)
	GTLVTVSS (SEQ ID NO: 4134)
371_H01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4304)
	GTLVTVSS (SEQ ID NO: 4135)
367_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4305)
	GTLVTVSS (SEQ ID NO: 4136)
365_F04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	FSSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4306)
	GTLVTVSS (SEQ ID NO: 4137)
370_A09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4307)
	GTLVTVSS (SEQ ID NO: 4138)
365_B03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4308)
	GTLVTVSS (SEQ ID NO: 4139)
369_A05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4309)
	GTLVTVSS (SEQ ID NO: 4140)
373_H10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4310)
	GTLVTVSS (SEQ ID NO: 4141)
367_A09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4311)
	GTLVTVSS (SEQ ID NO: 4142)
370_F08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4312)
	GTLVTVSS (SEQ ID NO: 4143)
376_B01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4313)
	GTLVTVSS (SEQ ID NO: 4144)
365_D05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4314)
	GTLVTVSS (SEQ ID NO: 4145)
373_E04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4315)
	GTLVTVSS (SEQ ID NO: 4146)
368_G05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4316)
	GTLVTVSS (SEQ ID NO: 4147)
365_A01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSDYGMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4317)
	GTLVTVSS (SEQ ID NO: 4148)
373_H06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSSYGMHWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4318)
	GTLVTVSS (SEQ ID NO: 4149)
369_G07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4319)
	GTLVTVSS (SEQ ID NO: 4150)
373_G05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4320)
	GTLVTVSS (SEQ ID NO: 4151)
372_F07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDDYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4321)
	GTLVTVSS (SEQ ID NO: 4152)
370_H03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4322)
	GTLVTVSS (SEQ ID NO: 4153)
366_A03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4323)
	GTLVTVSS (SEQ ID NO: 4154)
365_A07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYGMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4324)
	GTLVTVSS (SEQ ID NO: 4155)
376_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4325)
	GTLVTVSS (SEQ ID NO: 4156)
374_C11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4326)
	GTLVTVSS (SEQ ID NO: 4157)
375_A06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4327)
	GTLVTVSS (SEQ ID NO: 4158)
365_B09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILRYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4328)
	GTLVTVSS (SEQ ID NO: 4159)
373_E06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILRYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4329)
	GTLVTVSS (SEQ ID NO: 4160)
374_C05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIIRYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4330)
	GTLVTVSS (SEQ ID NO: 4161)
376_C11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4331)
	GTLVTVSS (SEQ ID NO: 4162)
373_C09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4332)
	GTLVTVSS (SEQ ID NO: 4163)
368_H01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4333)
	GTLVTVSS (SEQ ID NO: 4164)
373_B03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4334)
	GTLVTVSS (SEQ ID NO: 4165)
374_C04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4335)
	GTLVTVSS (SEQ ID NO: 4166)
371_F05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4336)
	GTLVTVSS (SEQ ID NO: 4167)
369_A10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4337)
	GTLVTVSS (SEQ ID NO: 4168)
366_A05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4338)
	GTLVTVSS (SEQ ID NO: 4169)
375_G07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4339)
	GTLVTVSS (SEQ ID NO: 4170)
374_D02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISTYVN
	FDSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4340)
	GTLVTVSS (SEQ ID NO: 4171)
365_A10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMHWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4341)
	GTLVTVSS (SEQ ID NO: 4172)
375_A02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FSSYSMNWVRQAPGKGLEWVAGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4342)
	GTLVTVSS (SEQ ID NO: 4173)
371_G03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	FSSYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4343)
	GTLVTVSS (SEQ ID NO: 4174)
370_E07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4344)
	GTLVTVSS (SEQ ID NO: 4175)
375_B04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4345)
	GTLVTVSS (SEQ ID NO: 4176)
367_G07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4346)
	GTLVTVSS (SEQ ID NO: 4177)
366_C02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSDYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4347)
	GTLVTVSS (SEQ ID NO: 4178)
375_C12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4348)
	GTLVTVSS (SEQ ID NO: 4179)
365_F08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDYGMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4349)
	GTLVTVSS (SEQ ID NO: 4180)
368_G09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYGMHWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4350)
	GTLVTVSS (SEQ ID NO: 4181)
368_E11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDSYGMHWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4351)
	GTLVTVSS (SEQ ID NO: 4182)
367_F02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDSYSMNWVRQAPGKGLEWVANINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4352)
	GTLVTVSS (SEQ ID NO: 4183)
373_B08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4353)
	GTLVTVSS (SEQ ID NO: 4184)
374_A11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4354)
	GTLVTVSS (SEQ ID NO: 4185)
373_B11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4355)
	GTLVTVSS (SEQ ID NO: 4186)
373_F03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4356)
	GTLVTVSS (SEQ ID NO: 4187)
372_D04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVANINYNSG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4357)
	GTLVTVSS (SEQ ID NO: 4188)
366_C01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSDYGMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSPASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4358)
	GTLVTVSS (SEQ ID NO: 4189)
367_A01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4359)
	GTLVTVSS (SEQ ID NO: 4190)
366_H05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4360)
	GTLVTVSS (SEQ ID NO: 4191)
369_B09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4361)
	GTLVTVSS (SEQ ID NO: 4192)
366_D07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4362)
	GTLVTVSS (SEQ ID NO: 4193)
369_D11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYGMHWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4363)
	GTLVTVSS (SEQ ID NO: 4194)
370_B05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYGMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4364)
	GTLVTVSS (SEQ ID NO: 4195)
366_D02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVASINYNGG	WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4365)
	GTLVTVSS (SEQ ID NO: 4196)
368_H12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4366)
	GTLVTVSS (SEQ ID NO: 4197)
368_F12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDDYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4367)
	GTLVTVSS (SEQ ID NO: 4198)
370_A06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSSYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4368)
	GTLVTVSS (SEQ ID NO: 4199)
369_F12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FSSYSMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAVTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4369)
	GTLVTVSS (SEQ ID NO: 4200)
366_A09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4370)
	GTLVTVSS (SEQ ID NO: 4201)
368_H07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMHWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4371)
	GTLVTVSS (SEQ ID NO: 4202)
370_C04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYGMNWVRQAPGKGLEWVASINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4372)
	GTLVTVSS (SEQ ID NO: 4203)
373_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLN
	FDSYGMHWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4373)
	GTLVTVSS (SEQ ID NO: 4204)
374_E09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSDYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4374)
	GTLVTVSS (SEQ ID NO: 4205)
371_C09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4375)
	GTLVTVSS (SEQ ID NO: 4206)
369_B12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYATTSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4376)
	GTLVTVSS (SEQ ID NO: 4207)
369_B02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4377)
	GTLVTVSS (SEQ ID NO: 4208)
365_C09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4378)
	GTLVTVSS (SEQ ID NO: 4209)
374_B09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVRYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4379)
	GTLVTVSS (SEQ ID NO: 4210)
374_D12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4380)
	GTLVTVSS (SEQ ID NO: 4211)
374_C02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4381)
	GTLVTVSS (SEQ ID NO: 4212)
374_H08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4382)
	GTLVTVSS (SEQ ID NO: 4213)
369_D06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4383)
	GTLVTVSS (SEQ ID NO: 4214)
366_B06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYAAPSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYXTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4384)
	GTLVTVSS (SEQ ID NO: 4215)
367_A11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMHWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLVIYATTSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4385)
	GTLVTVSS (SEQ ID NO: 4216)
369_F04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FSSYGMNWVRQAPGKGLEWVSGINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4386)
	GTLVTVSS (SEQ ID NO: 4217)
369_A01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4387)
	GTLVTVSS (SEQ ID NO: 4218)
373_H12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4388)
	GTLVTVSS (SEQ ID NO: 4219)
376_C07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4389)
	GTLVTVSS (SEQ ID NO: 4220)
366_E02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4390)
	GTLVTVSS (SEQ ID NO: 4221)
376_G01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FDDYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAVTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4391)
	GTLVTVSS (SEQ ID NO: 4222)
373_F02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4392)
	GTLVTVSS (SEQ ID NO: 4223)
376_E09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4393)
	GTLVTVSS (SEQ ID NO: 4224)
365_H04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSDYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4394)
	GTLVTVSS (SEQ ID NO: 4225)
369_E04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4395)
	GTLVTVSS (SEQ ID NO: 4226)
374_B11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4396)
	GTLVTVSS (SEQ ID NO: 4227)
376_G11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4397)
	GTLVTVSS (SEQ ID NO: 4228)
374_E04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4398)
	GTLVTVSS (SEQ ID NO: 4229)
373_B08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAVTSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4399)
	GTLVTVSS (SEQ ID NO: 4230)
375_B10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4400)
	GTLVTVSS (SEQ ID NO: 4231)
365_E08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYVN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4401)
	GTLVTVSS (SEQ ID NO: 4232)
374_G02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4402)
	GTLVTVSS (SEQ ID NO: 4233)
373_D09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4403)
	GTLVTVSS (SEQ ID NO: 4234)
365_A04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSDYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4404)
	GTLVTVSS (SEQ ID NO: 4235)
371_B05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSSYSMNWVRQAPGKGLEWVSGINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDETPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4405)
	GTLVTVSS (SEQ ID NO: 4236)
376_H08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDSLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4406)
	GTLVTVSS (SEQ ID NO: 4237)
367_G08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4407)
	GTLVTVSS (SEQ ID NO: 4238)
372_H03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIITYVN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4408)
	GTLVTVSS (SEQ ID NO: 4239)
366_E03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4409)
	GTLVTVSS (SEQ ID NO: 4240)
371_F12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSNNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4410)
	GTLVTVSS (SEQ ID NO: 4241)
366_C03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4411)
	GTLVTVSS (SEQ ID NO: 4242)
376_A01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4412)
	GTLVTVSS (SEQ ID NO: 4243)
365_E03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDERPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4413)
	GTLVTVSS (SEQ ID NO: 4244)
371_B10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4414)
	GTLVTVSS (SEQ ID NO: 4245)
369_G09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4415)
	GTLVTVSS (SEQ ID NO: 4246)
369_A06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4416)
	GTLVTVSS (SEQ ID NO: 4247)
369_C08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FSDYGMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4417)
	GTLVTVSS (SEQ ID NO: 4248)
373_A07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4418)
	GTLVTVSS (SEQ ID NO: 4249)
367_D02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYVN
	FDDYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYENPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4419)
	GTLVTVSS (SEQ ID NO: 4250)
374_C07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIISYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4420)
	GTLVTVSS (SEQ ID NO: 4251)
374_A03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4421)
	GTLVTVSS (SEQ ID NO: 4252)
365_A02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4422)
	GTLVTVSS (SEQ ID NO: 4253)
365_D06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4423)
	GTLVTVSS (SEQ ID NO: 4254)
366_C07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNGG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4424)
	GTLVTVSS (SEQ ID NO: 4255)
367_F12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDDYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4425)
	GTLVTVSS (SEQ ID NO: 4256)
369_E09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4426)
	GTLVTVSS (SEQ ID NO: 4257)
365_G02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSDYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAVTSLHSGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYELPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4427)
	GTLVTVSS (SEQ ID NO: 4258)
373_D02	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4428)
	GTLVTVSS (SEQ ID NO: 4259)
374_E03	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4429)
	GTLVTVSS (SEQ ID NO: 4260)
374_D11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYLN
	FDSYGMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4430)
	GTLVTVSS (SEQ ID NO: 4261)
370_D07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSSYGMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYESPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4431)
	GTLVTVSS (SEQ ID NO: 4262)
374_A08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4432)
	GTLVTVSS (SEQ ID NO: 4263)
374_G01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDSYSMNWVRQAPGKGLEWVSNINYNSG	WYQQKPGKAPKLLIYATTSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4433)
	GTLVTVSS (SEQ ID NO: 4264)
374_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FDDYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAATSLASGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNSPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4434)
	GTLVTVSS (SEQ ID NO: 4265)
375_G10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FSSYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4435)
	GTLVTVSS (SEQ ID NO: 4266)
369_H11	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FSDYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4436)
	GTLVTVSS (SEQ ID NO: 4267)
375_G12	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDSYGMHWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4437)
	GTLVTVSS (SEQ ID NO: 4268)
366_F06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISTYLN
	FSDYGMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4438)
	GTLVTVSS (SEQ ID NO: 4269)
368_G07	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYSMHWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4439)
	GTLVTVSS (SEQ ID NO: 4270)
367_H04	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILTYVN
	FSSYSMNWVRQAPGKGLEWVSSINYNGG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSDNNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4440)
	GTLVTVSS (SEQ ID NO: 4271)
374_E06	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYLN
	FDSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4441)
	GTLVTVSS (SEQ ID NO: 4272)
370_A10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSILSYVN
	FSDYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAATSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4442)
	GTLVTVSS (SEQ ID NO: 4273)
368_H10	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FSSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAVTSLASGVPSRFSGSGSG
	YKGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYETPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4443)
	GTLVTVSS (SEQ ID NO: 4274)
368_G08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYVN
	FDDYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAATSRHSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYNNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4444)
	GTLVTVSS (SEQ ID NO: 4275)
365_H09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FSSYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YKSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4445)
	GTLVTVSS (SEQ ID NO: 4276)
370_A08	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVTYLN
	FDSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDLPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4446)
	GTLVTVSS (SEQ ID NO: 4277)
368_B05	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYLN
	FDSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4447)
	GTLVTVSS (SEQ ID NO: 4278)
375_F01	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSIVSYLN
	FSSYSMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLVIYAATSRASGVPSRFSGSGSG
	YTGYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYDNPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4448)
	GTLVTVSS (SEQ ID NO: 4279)
374_F09	EVQLLESGGGLVQPGGSLRLSCAASGFT	DIQMTQSPSSLSASVGDRVTITCRASQSISSYVN
	FSSYGMNWVRQAPGKGLEWVSSINYNSG	WYQQKPGKAPKLLIYAATSRASGVPSRFSGSGSG
	YTSYADSVKGRFTISRDNSKNTLYLQMN	TDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGT
	SLRAEDTAVYYCARSATWHDTHLDYWGQ	KVEIK (SEQ ID NO: 4449)
	GTLVTVSS (SEQ ID NO: 4280)

Table 3F provides the amino acid sequences of the CDRs of the antibodies shown in Table 2F.

TABLE 3F
CDR sequences for Group VI antibodies
Ab	HCDR1	HCDR2	HCDR3	LCDR1	LCDR2	LCDR3
365_E02	SSYSMN	WVANINY	AKSATW	ISYLNWY	LLIYAATSRA	QQSYENPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5126)	NO:
	4450)	NO:	NO:	4957)		5295)
		4619)	4788)
370_G12	SSYSMN	WVAGINY	ARSATW	ITYLNWY	LLIYAATSLA	QQSDESPL
	(SEQ	NGGYKG	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5127)	NO:
	4451)	NO:	NO:	4958)		5296)
		4620)	4789)
368_C01	DSYGMN	WVAGINY	ARSATWH	ITYLNWY	LLIYAATSRA	QQSYDSPL
	(SEQ	NGGYTG	DTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5128)	NO:
	4452)	NO:	NO:	4959)		5297)
		4621)	4790)
376_C06	SSYGMN	WVAGINY	ARSATWH	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	NGGYTS	DTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5129)	NO:
	4453)	NO:	NO:	4960)		5298)
		4622)	4791)
368_D10	DSYGMN	WVAGINY	ARSATWH	LSYLNWY	LVIYAATSRA	QQSYDSPL
	(SEQ	NSGYTS	DTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5130)	NO:
	4454)	NO:	NO:	4961)		5299)
		4623)	4792)
365_G12	SSYGMN	WVAGINY	ARSATWH	LSYVNWY	LVIYAATSRA	QQSYSNPL
	(SEQ	NSGYTS	DTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5131)	NO:
	4455)	NO:	NO:	4962)		5300)
		4624)	4793)
367_C03	SSYSMN	WVANINY	ARSATW	LSYVNWY	LVIYATTSRA	QQSYENPL
	(SEQ	NGGYTG	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5132)	NO:
	4456)	NO:	NO:	4963)		5301)
		4625)	4794)
367_H07	SSYSMN	WVANINY	ARSATWH	LSYVNWY	LVIYATTSRA	QQSYENPL
	(SEQ	NGGYTG	DTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5133)	NO:
	4457)	NO:	NO:	4964)		5302)
		4626)	4795)
371_D03	DSYGMN	WVANINY	ARSATW	LTYVNWY	LVIYAATSLA	QQSYNTPL
	(SEQ	NGGYTS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5134)	NO:
	4458)	NO:	NO:	4965)		5303)
		4627)	4796)
369_C10	SSYSMN	WVANINY	ARSATW	VTYLNWY	LLIYAATSLH	QQSDSLPL
	(SEQ	NGGYTS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5135)	NO:
	4459)	NO:	NO:	4966)		5304)
		4628)	4797)
367_F05	SSYGMN	WVASINY	ARSATW	LSYVNWY	LLIYAATSRA	QQSYSSPL
	(SEQ	NGGYTG	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5136)	NO:
	4460)	NO:	NO:	4967)		5305)
		4629)	4798)
365_C07	SDYGMN	WVASINY	ARSATW	VSYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ	NGGYTS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5137)	NO:
	4461)	NO:	NO:	4968)		5306)
		4630)	4799)
374_C08	DSYGMN	WVSGINY	ARSATW	LSYVNWY	LLIYAVTSRA	QQSYDSPL
	(SEQ	NSGYKS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5138)	NO:
	4462)	NO:	NO:	4969)		5307)
		4631)	4800)
376_A06	DSYSMN	WVSGINY	ARSATW	LSYLNWY	LVIYYVSNRA	QQSYDNPL
	(SEQ	NSGYTS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5139)	NO:
	4463)	NO:	NO:	4970)		5308)
		4632)	4801)
376_B07	DSYSMN	WVSGINY	ARSATW	LSYLNWY	LVIYYVSNRA	QQSYDNPL
	(SEQ	NSGYTS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5140)	NO:
	4464)	NO:	NO:	4971)		5309)
		4633)	4802)
365_F07	SSYSMN	WVSNINY	ARSATW	LSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ	NGGYKS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5141)	NO:
	4465)	NO:	NO:	4972)		5310)
		4634)	4803)
369_E10	SSYSMN	WVSNINY	ARSATW	LSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ	NGGYKS	HDTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5142)	NO:
	4466)	NO:	NO:	4973)		5311)
		4635)	4804)
373_E03	DSYGMN	WVSNINY	ARSATWH	LSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ	NGGYTG	DTALD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5143)	NO:
	4467)	NO:	NO:	4974)		5312)
		4636)	4805)
366_B04	DSYSMN	WVAGINY	ARSATWH	LTYVNWY	LVIYAATSRH	QQSYDTPL
	(SEQ	NGGYKG	DTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5144)	NO:
	4468)	NO:	NO:	4975)		5313)
		4637)	4806)
376_F12	DDYSMN	WVAGINY	ARSATW	ISYVNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	NGGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5145)	NO:
	4469)	NO:	NO:	4976)		5314)
		4638)	4807)
369_F07	DSYSMN	WVAGIN	ARSATW	LSYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ	YNGGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5146)	NO:
	4470)	NO:	NO:	4977)		5315)
		4639)	4808)
368_C06	DSYSMN	WVAGINY	ARSATW	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	NGGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5147)	NO:
	4471)	NO:	NO:	4978)		5316)
		4640)	4809)
376_E12	SSYSMN	WVAGINY	ARSATW	LSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	NGGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5148)	NO:
	4472)	NO:	NO:	4979)		5317)
		4641)	4810)
371_H01	DSYSMN	WVAGINY	ARSATW	ITYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5149)	NO:
	4473)	NO:	NO:	4980)		5318)
		4642)	4811)
367_E02	DSYSMN	WVAGINY	ARSATW	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5150)	NO:
	4474)	NO:	NO:	4981)		5319)
		4643)	4812)
365_F04	SSYGMN	WVAGINY	ARSATW	VTYVNWY	LLIYAATSRA	QQSYDTPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5151)	NO:
	4475)	NO:	NO:	4982)		5320)
		4644)	4813)
370_A09	SSYSMN	WVAGINY	ARSATW	LTYLNWY	LVIYAATSRA	QQSYDTPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5152)	NO:
	4476)	NO:	NO:	4983)		5321)
		4645)	4814)
365_B03	SSYSMN	WVAGINY	ARSATW	VSYLNWY	LLIYAATSRA	QQSYENPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5153)	NO:
	4477)	NO:	NO:	4984)		5322)
		4646)	4815)
369_A05	SSYSMN	WVAGINY	ARSATW	LTYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5154)	NO:
	4478)	NO:	NO:	4985)		5323)
		4647)	4816)
373_H10	SSYSMN	WVAGINY	ARSATW	LSYVNWY	LLIYAATSRA	QQSYSLPL
	(SEQ	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5155)	NO:
	4479)	NO:	NO:	4986)		5324)
		4648)	4817)
367_A09	DSYGMN	WVAGINY	ARSATW	LSYVNWY	LVIYAATSRH	QQSYDTPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5156)	NO:
	4480)	NO:	NO:	4987)		5325)
		4649)	4818)
370_F08	DSYSMN	WVAGINY	ARSATW	ISYVNWY	LLIYAATSRH	QQSYNLPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5157)	NO:
	4481)	NO:	NO:	4988)		5326)
		4650)	4819)
376_B01	DSYSMN	WVAGINY	ARSATW	LTYVNWY	LVIYAATSRA	QQSYNLPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5158)	NO:
	4482)	NO:	NO:	4989)		5327)
		4651)	4820)
365_D05	DSYSMN	WVAGINY	ARSATW	LTYVNWY	LLIYAATSRA	QQSYNSPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5159)	NO:
	4483)	NO:	NO:	4990)		5328)
		4652)	4821)
373_E04	DSYSMN	WVAGINY	ARSATW	LTYVNWY	LLIYAATSRA	QQSYNSPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5160)	NO:
	4484)	NO:	NO:	4991)		5329)
		4653)	4822)
368_G05	DSYSMN	WVAGINY	ARSATW	LTYVNWY	LLIYAATSLH	QQSYNTPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5161)	NO:
	4485)	NO:	NO:	4992)		5330)
		4654)	4823)
365_A01	SDYGMN	WVAGINY	ARSATW	LTYVNWY	LVIYATTSLA	QQSYSTPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5162)	NO:
	4486)	NO:	NO:	4993)		5331)
		4655)	4824)
373_H06	SSYGMH	WVAGINY	ARSATW	ISYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5163)	NO:
	4487)	NO:	NO:	4994)		5332)
		4656)	4825)
369_G07	SSYSMN	WVAGINY	ARSATW	LTYVNWY	LVIYAATSRA	QQSYDNPL
	(SEQ	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	ID NO:	(SEQ ID	(SEQ ID	NO:	NO: 5164)	NO:
	4488)	NO:	NO:	4995)		5333)
		4657)	4826)
373_G05	SSYSMN	WVAGINY	ARSATW	LSYLNWY	LLIYAATSLA	QQSYELPL
	(SEQ ID	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4489)	(SEQ ID	(SEQ ID	NO: 4996)	NO: 5165)	NO:
		NO:	NO: 4827)			5334)
		4658)
372_F07	DDYSMN	WVAGINY	ARSATW	LTYLNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4490)	(SEQ ID	(SEQ ID	NO: 4997)	NO: 5166)	NO: 5335)
		NO:	NO: 4828)
		4659)
370_H03	DSYSMN	WVAGINY	ARSATW	LTYLNWY	LLIYAATSLA	QQSYDTPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4491)	(SEQ ID	(SEQ ID	NO: 4998)	NO: 5167)	NO: 5336)
		NO:	NO: 4829)
		4660)
366_A03	DSYSMN	WVAGINY	ARSATW	SSYLNWY	LLIYAATSLA	QQSYSNPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4492)	(SEQ ID	(SEQ ID	NO: 4999)	NO: 5168)	NO: 5337)
		NO:	NO: 4830)
		4661)
365_A07	SSYGMN	WVAGINY	ARSATW	VSYLNWY	LLIYAATSRA	QQSYNLPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4493)	(SEQ ID	(SEQ ID	NO: 5000)	NO: 5169)	NO: 5338)
		NO:	NO: 4831)
		4662)
376_B06	SSYSMN	WVAGINY	ARSATW	LTYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4494)	(SEQ ID	(SEQ ID	NO: 5001)	NO: 5170)	NO: 5339)
		NO:	NO: 4832)
		4663)
374_C11	SSYSMN	WVAGINY	ARSATW	LTYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4495)	(SEQ ID	(SEQ ID	NO: 5002)	NO: 5171)	NO: 5340)
		NO:	NO: 4833)
		4664)
375_A06	SSYSMN	WVAGINY	ARSATW	LTYVNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4496)	(SEQ ID	(SEQ ID	NO: 5003)	NO: 5172)	NO: 5341)
		NO:	NO: 4834)
		4665)
365_B09	DSYSMN	WVAGINY	ARSATW	LRYLNWY	LLIYAATSLH	QQSYDNPL
	(SEQ ID	NSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4497)	(SEQ ID	(SEQ ID	NO: 5004)	NO: 5173)	NO: 5342)
		NO:	NO: 4835)
		4666)
373_E06	DSYSMN	WVAGINY	ARSATW	LRYLNWY	LLIYAATSLH	QQSYDNPL
	(SEQ ID	NSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO: 4498)	(SEQ ID	(SEQ ID	NO: 5005)	NO: 5174)	NO: 5343)
		NO:	NO: 4836)
		4667)
374_C05	DSYSMN	WVAGINY	ARSAT	IRYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4499)	NO:	NO:	5006)	5175)	5344)
		4668)	4837)
376_C11	DSYSMN	WVAGINY	ARSAT	LTYLNWY	LVIYAATSRA	QQSYDNPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4500)	NO:	NO:	5007)	5176)	5345)
		4669)	4838)
373_C09	DSYSMN	WVAGINY	ARSAT	LTYLNWY	LVIYAATSRA	QQSYELPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4501)	NO:	NO:	5008)	5177)	5346)
		4670)	4839)
368_H01	SSYSMN	WVAGINY	ARSAT	LSYLNWY	LLIYATTSLA	QQSYDNPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4502)	NO:	NO:	5009)	5178)	5347)
		4671)	4840)
373_B03	SSYSMN	WVAGINY	ARSAT	LTYLNWY	LVIYAATSLA	QQSYDNPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4503)	NO:	NO:	5010)	5179)	5348)
		4672)	4841)
374__C04	SSYSMN	WVAGINY	ARSAT	LTYLNWY	LLIYAASSLQ	QQSYELPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4504)	NO:	NO:	5011)	5180)	5349)
		4673)	4842)
371_F05	SSYSMN	WVAGINY	ARSAT	LSYLNWY	LLIYAATSRH	QQSYENPL
	(SEQ ID	NSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4505)	NO:	NO:	5012)	5181)	5350)
		4674)	4843)
369__A10	DSYSMN	WVAGINY	ARSAT	LSYLNWY	LLIYAATSRA	QQSYELPL
	(SEQ ID	NSGY	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	TG	(SEQ ID	NO:	NO:	NO:
	4506)	(SEQ ID	NO:	5013)	5182)	5351)
		NO:	4844)
		4675)
366_A05	SSYSMN	WVAGINY	ARSAT	LTYVNWY	LVIYAATSLA	QQSYNTPL
	(SEQ ID	NSGY	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	TG	(SEQ ID	NO:	NO:	NO:
	4507)	(SEQ ID	NO:	5014)	5183)	5352)
		NO:	4845)
		4676)
375_G07	DSYSMN	WVAGINY	ARSAT	LSYLNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	NSGY	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	TS	(SEQ ID	NO:	NO:	NO:
	4508)	(SEQ ID	NO:	5015)	5184)	5353)
		NO:	4846)
		4677)
374_D02	DSYSMN	WVAGINY	ARSAT	STYVNWY	LLIYAVTSLA	QQSYDSPL
	(SEQ ID	NSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO: 5354)
	4509)	NO:	NO:	5016)	5185)
		4678)	4847)
365_A10	SSYGMH	WVAGINY	ARSAT	LTYLNWY	LVIYAVTSLA	QQSYDSPL
	(SEQ ID	NSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5017)	NO:	NO: 5355)
	4510)	NO:	NO:		5186)
		4679)	4848)
375_A02	SSYSMN	WVAGINY	ARSAT	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	NSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5018)	NO:	NO: 5356)
	4511)	NO:	NO:		5187)
		4680)	4849)
371_G03	SSYGMN	WVANINY	ARSAT	VTYVNWY	LVIYAATSLA	QQSYNLPL
	(SEQ ID	NGGYKG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5019)	NO:	NO: 5357)
	4512)	NO:	NO:		5188)
		4681)	4850)
370_E07	DSYSMN	WVANINY	ARSAT	LTYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	NGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5020)	NO:	NO: 5358)
	4513)	NO:	NO:		5189)
		4682)	4851)
375_B04	DSYSMN	WVANINY	ARSAT	LTYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	NGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5021)	NO:	NO:
	4514)	NO:	NO:		5190)	5359)
		4683)	4852)
367_G07	DSYSMN	WVANINY	ARSAT	LTYVNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	NGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5022)	NO:	NO: 5360)
	4515)	NO:	NO:		5191)
		4684)	4853)
366_C02	SDYSMN	WVANINY	ARSAT	VSYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	NGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5023)	NO:	NO: 5361)
	4516)	NO:	NO:		5192)
		4685)	4854)
375_C12	SSYSMN	WVANINY	ARSAT	LTYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	NGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5024)	NO:	NO: 5362)
	4517)	NO:	NO:		5193)
		4686)	4855)
365_F08	DDYGMN	WVANINY	ARSAT	LSYVNWY	LLIYAATSRH	QQSYSLPL
	(SEQ ID	NGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO: 5025)	NO:	NO: 5363)
	4518)	NO:	NO:		5194)
		4687)	4856)
368_G09	DSYGMH	WVANIN	ARSAT	VSYLN	LVIYAATSRA	QQSYDTPL
	(SEQ ID	YNGGYTS	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4519)	NO:	NO:	NO:	5195)	5364)
		4688)	4857)	5026)
368_E11	DSYGMH	WVANIN	ARSAT	ISYVN	LLIYAATSRH	QQSYELPL
	(SEQ ID	YNGGYTS	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4520)	NO:	NO:	NO:	5196)	5365)
		4689)	4858)	5027)
367_F02	DSYSMN	WVANIN	ARSAT	ISYVN	LLIYAATSRH	QQSYESPL
	(SEQ ID	YNGGYTS	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4521)	NO:	NO:	NO:	5197)	5366)
		4690)	4859)	5028)
373_B08	DSYSMN	WVANIN	ARSAT	LTYLN	LVIYAATSLA	QQSYENPL
	(SEQ ID	YNSGYKG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4522)	NO:	NO:	NO:	5198)	5367)
		4691)	4860)	5029)
374_A11	SDYSMN	WVANIN	ARSAT	LSYVN	LVIYAATSRA	QQSYSSPL
	(SEQ ID	YNSGYKG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4523)	NO:	NO:	NO:	5199)	5368)
		4692)	4861)	5030)
373_B11	SSYSMN	WVANIN	ARSAT	LSYLN	LLIYAATSRA	QQSYDNPL
	(SEQ ID	YNSGYKG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4524)	NO:	NO:	NO:	5200)	5369)
		4693)	4862)	5031)
373_F03	DSYSMN	WVANIN	ARSAT	LTYVN	LLIYAATSRH	QQSYDSPL
	(SEQ ID	YNSGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4525)	NO:	NO:	NO:	5201)	5370)
		4694)	4863)	5032)
372_D04	SSYSMN	WVANIN	ARSAT	LTYLN	LLIYAATSLH	QQSYDLPL
	(SEQ ID	YNSGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4526)	NO:	NO:	NO:	5202)	5371)
		4695)	4864)	5033)
366_C01	SDYGMN	WVASIN	ARSAT	VTYLN	LLIYAATSPA	QQSYELPL
	(SEQ ID	YNGGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4527)	NO:	NO:	NO:	5203)	5372)
		4696)	4865)	5034)
367_A01	SSYSMN	WVASIN	ARSAT	LTYLN	LLIYAATSRA	QQSYDLPL
	(SEQ ID	YNGGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4528)	NO:	NO:	NO:	5204)	5373)
		4697)	4866)	5035)
366_H05	DSYGMH	WVASIN	ARSAT	LSYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4529)	NO:	NO:	5036)	5205)	5374)
		4698)	4867)
369_B09	DSYGMH	WVASIN	ARSAT	LTYLNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4530)	NO:	NO:	5037)	5206)	5375)
		4699)	4868)
366_D07	SDYGMH	WVASIN	ARSAT	LTYLNWY	LLIYAATSLA	QQSYSSPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4531)	NO:	NO:	5038)	5207)	5376)
		4700)	4869)
369_D11	SSYGMH	WVASIN	ARSAT	LTYLNWY	LVIYAATSLA	QQSDELPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4532)	NO:	NO:	5039)	5208)	5377)
		4701)	4870)
370_B05	SSYGMN	WVASIN	ARSAT	LTYVNWY	LVIYAATSRA	QQSYENPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4533)	NO:	NO:	5040)	5209)	5378)
		4702)	4871)
366_D02	SSYSMN	WVASIN	ARSAT	LSYVNWY	LLIYATTSLA	QQSYDLPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4534)	NO:	NO:	5041)	5210)	5379)
		4703)	4872)
368_H12	DSYSMN	WVASIN	ARSAT	VTYLNWY	LLIYAATSRA	QQSYESPL
	(SEQ ID	YNSGYKG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4535)	NO:	NO:	5042)	5211)	5380)
		4704)	4873)
368_F12	DDYSMN	WVASIN	ARSAT	VTYLNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	YNSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4536)	NO:	NO:	5043)	5212)	5381)
		4705)	4874)
370_A06	SSYSMN	WVASIN	ARSAT	VTYLNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	YNSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4537)	NO:	NO:	5044)	5213)	5382)
		4706)	4875)
369_F12	SSYSMN	WVASIN	ARSAT	ISYLNWY	LLIYAVTSLA	QQSYENPL
	(SEQ ID	YNSGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4538)	NO:	NO:	5045)	5214)	5383)
		4707)	4876)
366_A09	SDYGMH	WVAS	ARSATW	LTYLNW	LLIYAATSRH	QQSYETPL
	(SEQ ID	INYN	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	SGYTS	(SEQ ID	(SEQ ID	NO:	NO:
	4539)	(SEQ ID	NO:	NO:	5215)	5384)
		NO:	4877)	5046)
		4708)
368_H07	SSYCMH	WVAS	ARSATW	LSYLNW	LLIYAATSRA	QQSYENPL
	(SEQ ID	INYN	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	SGYTS	(SEQ ID	(SEQ ID	NO:	NO:
	4540)	(SEQ ID	NO:	NO:	5216)	5385)
		NO:	4878)	5047)
		4709)
370_C04	SSYGMN	WVAS	ARSATW	LSYLNW	LLIYAASSLQ	QQSYENPL
	(SEQ ID	INYN	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	SGYTS	(SEQ ID	(SEQ ID	NO:	NO:
	4541)	(SEQ ID	NO:	NO:	5217)	5386)
		NO:	4879)	5048)
		4710)
373_E02	DSYGMH	WVSG	ARSATW	VRYLNW	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	INYNG	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	GYKG	(SEQ ID	(SEQ ID	NO:	NO:
	4542)	(SEQ ID	NO:	NO:	5218)	5387)
		NO:	4880)	5049)
		4711)
374_E09	SDYSMN	WVSG	ARSATW	VTYLNW	LVIYAATSRA	QQSYDSPL
	(SEQ ID	INYNG	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	GYKG	(SEQ ID	(SEQ ID	NO:	NO:
	4543)	(SEQ ID	NO:	NO:	5219)	5388)
		NO:	4881)	5050)
		4712)
371_C09	DSYSMN	WVSG	ARSATW	LTYVNW	LLIYAASSLQ	QQSYDNPL
	(SEQ ID	INYNG	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	GYKS	(SEQ ID	(SEQ ID	NO:	NO:
	4544)	(SEQ ID	NO:	NO:	5220)	5389)
		NO:	4882)	5051)
		4713)
369_B12	DSYSMN	WVS	ARSATW	LTYVNW	LLIYATTSLA	QQSYDSPL
	(SEQ ID	GINYN	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	GGYKS	(SEQ ID	(SEQ ID	NO:	NO:
	4545)	(SEQ ID	NO:	NO:	5221)	5390)
		NO:	4883)	5052)
		4714)
369_B02	DSYSMN	WVSG	ARSATW	LSYLNW	LVIYAATSRA	QQSYNLPL
	(SEQ ID	INYN	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	GGYKS	(SEQ ID	(SEQ ID	NO:	NO:
	4546)	(SEQ ID	NO:	NO:	5222)	5391)
		NO:	4884)	5053)
		4715)
365_C09	SDYGMN	W	ARSATW	VSYVNW	LLIYAATSRA	QQSYDTPL
	(SEQ ID	VSGIN	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	YNGGYKS	(SEQ ID	(SEQ ID	NO:	NO:
	4547)	(SEQ ID	NO:	NO:	5223)	5392)
		NO:	4885)	5054)
		4716)
374_B09	SSYSMN	WVSGIN	ARSATW	VRYLNW	LVIYAATSLA	QQSYELPL
	(SEQ ID	YNGGYKS	HDTHLD	Y	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4548)	NO:	NO:	NO:	5224)	5393)
		4717)	4886)	5055)
374_D12	DSYSMN	WVSGINY	ARSATW	VSYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4549)	NO:	NO:	5056)	5225)	5394)
		4718)	4887)
374_C02	DSYSMN	WVSGINY	ARSATW	LSYLNWY	LLIYAATSRH	QQSYDSPL
	(SEQ ID	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4550)	NO:	NO:	5057)	5226)	5395)
		4719)	4888)
374_H08	DSYSMN	WVSGINY	ARSATW	LSYLNWY	LLIYAATSLH	QQSYENPL
	(SEQ ID	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4551)	NO:	NO:	5058)	5227)	5396)
		4720)	4889)
369_D06	DSYSMN	WVSGINY	ARSATW	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	NGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4552)	NO:	NO:	5059)	5228)	5397)
		4721)	4890)
366_B06	DSYSMN	WVSGINY	ARSATW	LTYVNWY	LVIYAAPSLA	QQSYXTPL
	(SEQ ID	NGGYTS		(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	HDTHLD	NO:	NO:	NO:
	4553)	NO:	(SEQ ID	5060)	5229)	5398)
		4722)	NO:
			4891)
367_A11	SSYGMH	WVSGINY	ARSATW	LSYVNWY	LVIYATTSLA	QQSY
	(SEQ ID	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	NSPL
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	(SEQ ID
	4554)	NO:	NO:	5061)	5230)	NO:
		4723)	4892)			5399)
369_F04	SSYGMN	WVSGINY	ARSATW	ISYVNWY	LLIYAATSRH	QQSYDNPL
	(SEQ ID	NGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4555)	NO:	NO:	5062)	5231)	5400)
		4724)	4893)
369_A01	DSYSMN	WVSGINY	ARSATW	LTYVNWY	LVIYAATSLA	QQSYELPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4556)	NO:	NO:	5063)	5232)	5401)
		4725)	4894)
373_H12	SDYSMN	WVSGINY	ARSATW	LTYLNWY	LLIYAATSRA	QQSY
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	NSPL
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	(SEQ ID
	4557)	NO:	NO:	5064)	5233)	NO:
		4726)	4895)			5402)
376_C07	SSYSMN	WVSGINY	ARSATW	LSYVNWY	LLIYAATSRH	QQSYDLPL
	(SEQ ID	NSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4558)	NO:	NO:	5065)	5234)	5403)
		4727)	4896)
366_E02	SSYSMN	WVSGIN	ARSATW	SSYLNWY	LLIYAASSLQ	QQSYNSPL
	(SEQ ID	YNSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4559)	NO:	NO:	5066)	5235)	5404)
		4728)	4897)
376_G01	DDYSMN	WVSGIN	ARSATW	LSYVNWY	LVIYAVTSRA	QQSYELPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4560)	NO:	NO:	5067)	5236)	5405)
		4729)	4898)
373_F02	DSYSMN	WVSGIN	ARSATW	LTYLNWY	LLIYAATSRA	QQSYDTPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4561)	NO:	NO:	5068)	5237)	5406)
		4730)	4899)
376_E09	DSYSMN	WVSGIN	ARSATW	LTYLNWY	LLIYAATSRH	QQSYDTPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4562)	NO:	NO:	5069)	5238)	5407)
		4731)	4900)
365_H04	SDYGMN	WVSGIN	ARSATW	LTYVNWY	LVIYAATSRA	QQSYESPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4563)	NO:	NO:	5070)	5239)	5408)
		4732)	4901)
369_E04	SDYSMN	WVSGIN	ARSATW	LSYVNWY	LVIYAATSRA	QQSYSLPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4564)	NO:	NO:	5071)	5240)	5409)
		4733)	4902)
374_B11	SSYSMN	WVSGIN	ARSATW	LTYVNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4565)	NO:	NO:	5072)	5241)	5410)
		4734)	4903)
376_G11	SSYSMN	WVSGIN	ARSATW	VTYVNWY	LVIYAATSLA	QQSYNLPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4566)	NO:	NO:	5073)	5242)	5411)
		4735)	4904)
374_E04	SSYSMN	WVSGIN	ARSATW	LSYLNWY	LLIYAVTSRA	QQSYNNPL
	(SEQ ID	YNSGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4567)	NO:	NO:	5074)	5243)	5412)
		4736)	4905)
373_E08	DSYGMN	WVSGIN	ARSATW	VSYVNWY	LLIYAVTSRA	QQSYESPL
	(SEQ ID	YNSGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4568)	NO:	NO:	5075)	5244)	5413)
		4737)	4906)
375_B10	DSYSMN	WVSGIN	ARSAT	LSYLNWY	LLIYAATSRH	QQSYDLPL
	(SEQ ID	YNSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4569)	NO:	NO:	5076)	5245)	5414)
		4738)	4907)
365_E08	DSYSMN	WVSGIN	ARSAT	ISYVNWY	LVIYAATSLA	QQSYDLPL
	(SEQ ID	YNSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4570)	NO:	NO:	5077)	5246)	5415)
		4739)	4908)
374_G02	DSYSMN	WVSGIN	ARSAT	LTYLNWY	LLIYAASSLQ	QQSYDTPL
	(SEQ ID	YNSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4571)	NO:	NO:	5078)	5247)	5416)
		4740)	4909)
373_D09	DSYSMN	WVSGIN	ARSAT	LTYLNWY	LVIYAATSRH	QQSYENPL
	(SEQ ID	YNSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4572)	NO:	NO:	5079)	5248)	5417)
		4741)	4910)
365_A04	SDYSMN	WVSGIN	ARSAT	VSYVNWY	LVIYAATSLA	QQSYSTPL
	(SEQ ID	YNSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4573)	NO:	NO:	5080)	5249)	5418)
		4742)	4911)
371_B05	SSYSMN	WVSGIN	ARSAT	LTYLNWY	LVIYAATSLA	QQSDETPL
	(SEQ ID	YNSGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4574)	NO:	NO:	5081)	5250)	5419)
		4743)	4912)
376_H08	DSYGMN	WVSNIN	ARSAT	LTYLNWY	LLIYAATSRH	QQSDSLPL
	(SEQ ID	YNGGYKG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4575)	NO:	NO:	5082)	5251)	5420)
		4744)	4913)
367_G08	DSYGMN	WVSNIN	ARSAT	LSYLNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	YNGGYKG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4576)	NO:	NO:	5083)	5252)	5421)
		4745)	4914)
372_H03	DSYGMN	WVSNIN	ARSAT	ITYVNWY	LLIYAATSLA	QQSYNLPL
	(SEQ ID	YNGGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4577)	NO:	NO:	5084)	5253)	5422)
		4746)	4915)
366_E03	DSYGMN	WVSNIN	ARSAT	LTYLNWY	LVIYAATSRH	QQSYSNPL
	(SEQ ID	YNGGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4578)	NO:	NO:	5085)	5254)	5423)
		4747)	4916)
371_F12	DSYSMN	WVSNIN	ARSAT	ISYLNWY	LLIYAATSRA	QQSNNLPL
	(SEQ ID	YNGGYKS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4579)	NO:	NO:	5086)	5255)	5424)
		4748)	4917)
366_C03	DSYGMN	WVSNIN	ARSAT	LSYLNWY	LVIYAATSRA	QQSYSNPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4580)	NO:	NO:	5087)	5256)	5425)
		4749)	4918)
376_A01	DSYGMN	WVSNIN	ARSAT	VSYLNWY	LLIYAATSRA	QQSYSTPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4581)	NO:	NO:	5088)	5257)	5426)
		4750)	4919)
365_E03	DSYSMN	WVSNIN	ARSAT	LTYVNWY	LLIYAATSLH	QQSDERPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4582)	NO:	NO:	5089)	5258)	5427)
		4751)	4920)
371_B10	DSYSMN	WVSNIN	ARSAT	VSYVNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4583)	NO:	NO:	5090)	5259)	5428)
		4752)	4921)
369_G09	DSYSMN	WVSNIN	ARSAT	VTYLNWY	LLIYAATSRA	QQSYDLPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4584)	NO:	NO:	5091)	5260)	5429)
		4753)	4922)
369_A06	SDYGMN	WVSNIN	ARSAT	LSYVNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4585)	NO:	NO:	5092)	5261)	5430)
		4754)	4923)
369_C08	SDYGMN	WVSNIN	ARSAT	LTYLNWY	LVIYAATSLA	QQSYENPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4586)	NO:	NO:	5093)	5262)	5431)
		4755)	4924)
373_A07	SSYSMN	WVSNIN	ARSAT	LTYVNWY	LLIYAATSRA	QQSDNLPL
	(SEQ ID	YNGGYTG	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4587)	NO:	NO:	5094)	5263)	5432)
		4756)	4925)
367_D02	DDYSMN	WVSNIN	ARSAT	VTYVNWY	LLIYAATSRA	QQSYENPL
	(SEQ ID	YNGGYTS	WHDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4588)	NO:	NO:	5095)	5264)	5433)
		4757)	4926)
374_C07	DSYSMN	WVSNIN	ARSATW	ISYLNWY	LLIYAATSRA	QQSDELPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4589)	NO:	NO:	5096)	5265)	5434)
		4758)	4927)
374_A03	DSYSMN	WVSNIN	ARSATW	LTYLNWY	LLIYAATSRA	QQSYDNPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4590)	NO:	NO:	5097)	5266)	5435)
		4759)	4928)
365_A02	DSYSMN	WVSNIN	ARSATW	LTYVNWY	LLIYAATSRA	QQSYNSPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4591)	NO:	NO:	5098)	5267)	5436)
		4760)	4929)
365_D06	DSYSMN	WVSNIN	ARSATW	LTYVNWY	LLIYAATSRA	QQSYSLPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4592)	NO:	NO:	5099)	5268)	5437)
		4761)	4930)
366_C07	SSYSMN	WVSNIN	ARSATW	LTYVNWY	LLIYAATSRA	QQSYNSPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4593)	NO:	NO:	5100)	5269)	5438)
		4762)	4931)
367_F12	DDYSMN	WVSNIN	ARSATW	SSYLNWY	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	YNSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4594)	NO:	NO:	5101)	5270)	5439)
		4763)	4932)
369_E09	DSYSMN	WVSNIN	ARSATW	LSYLNWY	LVIYAATSRA	QQSYDLPL
	(SEQ ID	YNSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4595)	NO:	NO:	5102)	5271)	5440)
		4764)	4933)
365_G02	SDYSMN	WVSNIN	ARSATW	VTYLNWY	LVIYAVTSLH	QQSYELPL
	(SEQ ID	YNSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4596)	NO:	NO:	5103)	5272)	5441)
		4765)	4934)
373_D02	SSYSMN	WVSNIN	ARSATW	LSYLNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	YNSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4597)	NO:	NO:	5104)	5273)	5442)
		4766)	4935)
374_E03	SSYSMN	WVSNIN	ARSATW	LTYVNWY	LVIYAATSLA	QQSYDTPL
	(SEQ ID	YNSGYKG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4598)	NO:	NO:	5105)	5274)	5443)
		4767)	4936)
374_D11	DSYGMN	WVSNIN	ARSATW	LTYLNWY	LLIYAATSRA	QQSYETPL
	(SEQ ID	YNSGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4599)	NO:	NO:	5106)	5275)	5444)
		4768)	4937)
370_D07	SSYGMN	WVSNIN	ARSATW	LSYVNWY	LVIYAATSLA	QQSYESPL
	(SEQ ID	YNSGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4600)	NO:	NO:	5107)	5276)	5445)
		4769)	4938)
374_A08	DSYSMN	WVSNIN	ARSATW	VTYLNWY	LLIYAATSLA	QQSYDLPL
	(SEQ ID	YNSGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4601)	NO:	NO:	5108)	5277)	5446)
		4770)	4939)
374_G01	DSYSMN	WVSNIN	ARSATW	LTYVNWY	LLIYATTSRH	QQSYNLPL
	(SEQ ID	YNSGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4602)	NO:	NO:	5109)	5278)	5447)
		4771)	4940)
374_G12	DDYGMN	WVSSIN	ARSATW	LTYVNWY	LVIYAATSLA	QQSYNSPL
	(SEQ ID	YNGGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4603)	NO:	NO:	5110)	5279)	5448)
		4772)	4941)
375_G10	SSYGMN	WVSSIN	ARSATW	VTYLNWY	LVIYAATSRH	QQSYDTPL
	(SEQ ID	YNGGYKS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4604)	NO:	NO:	5111)	5280)	5449)
		4773)	4942)
369_H11	SDYGMN	WVSSIN	ARSATW	LSYLNWY	LLIYAATSRH	QQSYDLPL
	(SEQ ID	YNGGYTG	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4605)	NO:	NO:	5112)	5281)	5450)
		4774)	4943)
375_G12	DSYGMH	WVSSIN	ARSATW	VSYVNWY	LLIYAATSRH	QQSYDTPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4606)	NO:	NO:	5113)	5282)	5451)
		4775)	4944)
366_F06	SDYGMN	WVSSIN	ARSATW	STYLNWY	LLIYAATSLA	QQSYSNPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4607)	NO:	NO:	5114)	5283)	5452)
		4776)	4945)
368_G07	SSYSMH	WVSSIN	ARSATW	VSYVNWY	LVIYAATSRA	QQSYDTPL
	(SEQ ID	YNGGYTS	HDTHLD	(SEQ ID	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	NO:	NO:	NO:
	4608)	NO:	NO:	5115)	5284)	5453)
		4777)	4946)
367_H04	SSYSMN	WVSSINY	ARSAT	LTYVN	LLIYAATSRH	QQSDNNPL
	(SEQ ID	NGGYTS	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4609)	NO:	NO:	NO:	5285)	5454)
		4778)	4947)	5116)
374_E06	DSYSMN	WVSSINY	ARSAT	LSYLN	LLIYAATSRA	QQSYDLPL
	(SEQ ID	NSGYKG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4610)	NO:	NO:	NO:	5286)	5455)
		4779)	4948)	5117)
370_A10	SDYSMN	WVSSINY	ARSAT	LSYVN	LLIYAATSLA	QQSYDTPL
	(SEQ ID	NSGYKG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4611)	NO:	NO:	NO:	5287)	5456)
		4780)	4949)	5118)
368_H10	SSYSMN	WVSSINY	ARSAT	VSYVN	LVIYAVTSLA	QQSYETPL
	(SEQ ID	NSGYKG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4612)	NO:	NO:	NO:	5288)	5457)
		4781)	4950)	5119)
368_G08	DDYGMN	WVSSINY	ARSAT	VSYVN	LLIYAATSRH	QQSY
	(SEQ ID	NSGYKS	WHDTHLD	WY	(SEQ ID	NNPL
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	(SEQ ID
	4613)	NO:	NO:	NO:	5289)	NO:
		4782)	4951)	5120)		5458)
365_H09	SSYGMN	WVSSINY	ARSAT	SSYLN	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	NSGYKS	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4614)	NO:	NO:	NO:	5290)	5459)
		4783)	4952)	5121)
370_A08	DSYSMN	WVSSINY	ARSAT	VTYLN	LVIYAATSRA	QQSYDLPL
	(SEQ ID	NSGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4615)	NO:	NO:	NO:	5291)	5460)
		4784)	4953)	5122)
368_B05	DSYSMN	WVSSINY	ARSAT	SSYLN	LLIYAASSLQ	QQSYSTPL
	(SEQ ID	NSGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4616)	NO:	NO:	NO:	5292)	5461)
		4785)	4954)	5123)
375_F01	SSYSMN	WVSSINY	ARSAT	VSYLN	LVIYAATSRA	QQSYDNPL
	(SEQ ID	NSGYTG	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4617)	NO:	NO:	NO:	5293)	5462)
		4786)	4955)	5124)
374_F09	SSYGMN	WVSSINY	ARSAT	SSYVN	LLIYAATSRA	QQSYSTPL
	(SEQ ID	NSGYTS	WHDTHLD	WY	(SEQ ID	(SEQ ID
	NO:	(SEQ ID	(SEQ ID	(SEQ ID	NO:	NO:
	4618)	NO:	NO:	NO:	5294)	5463)
		4787)	4956)	5125)

The consensus sequences for each of these CDRs shown in FIG. 3F are as follows:

HCDR1:
(SEQ ID NO: 6584)
D/SS/DYS/GMN/H
HCDR2:
(SEQ ID NO: 6585)
WVA/SG/N/SINYNG/SGYT/KS/G
HCDR3:
(SEQ ID NO: 6586)
ARSATWHDTH/ALD
LCDR1:
(SEQ ID NO: 6588)
L/V/I/SS/T/RYL/VNWY
LCDR2:
(SEQ ID NO: 6590)
LL/VIYA/YA/V/TT/SS/NR/LA/H/Q
LCDR3:
(SEQ ID NO: 6591)
QQSY/DD/E/S/NL/N/T/SPL

The present antibody may exhibit high affinity binding to ACVR2A. For example, the antibody may binds to ACVR2 with an affinity of at least about 10⁻⁷ M, at least about 10⁻⁸M, at least about 10⁻⁹ M, at least about 10⁻¹⁰ M, at least about 10⁻¹¹ M, or at least about 10⁻¹² M, or greater than 10⁻¹² M. The present antibody binds to ACVR2A with a substantially lower affinity, e.g., at least 10 fold, 50 fold, 100 fold, 500 fold, 1000 fold, 5000 fold, 10,000 fold, 50,000 fold 100,000, or 500,000 fold lower affinity.

The present antibody may reduce binding of ACVR2A to GDF8 and/or other activins. For example, the antibody may reduce binding of ACVR2A to GDF8 and/or other activins by at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, or more, compared to the degree of binding between ACVR2A and GDF8 and/or other activins in the absence of the antibody.

In some embodiments, an antibody comprises one or more (e.g., one or two) heavy chain variable regions (VH) and/or one or more (e.g., one or two) light chain variable regions (VL), or subfragments thereof capable of binding an epitope. The VH and VL regions can be further subdivided into regions of hypervariability, termed “complementarity determining regions (CDR)”, interspersed with regions that are more conserved, termed “framework regions (FR)”. The extent of the FR and CDRs has been precisely defined (see, Kabat, et al. (1991) Sequences of Proteins of Immunological Interest, Fifth Edition, U.S. Department of Health and Human Services, NIH Publication No. 91-3242; Chothia et al. (1987) J. Mol. Biol. 196: 901-917). A VH can comprise three CDRs and four FRs arranged from N-terminus to C-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4. Similarly, a VL can comprise three CDRs and four FRs arranged from N-terminus to C-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4.

The VH or VL chain of an antibody can further include all or part of a heavy or light chain constant region, to thereby form a heavy or light immunoglobulin chain, respectively. In one embodiment, the antibody is a tetramer of two heavy and two light chains, wherein the heavy and light chains are interconnected by, for example, disulphide bonds. The heavy chain constant region is comprised of three domains, CH1, CH2 and CH3. The light chain constant region is comprised of one domain, CL. The variable regions of the heavy and light chains comprise binding regions that interact with antigen. The constant regions of the antibodies typically mediate the binding of the antibody to host tissues and factors, including various cells of the immune system and the first component of the complement system. The term “antibody” includes intact immunoglobulins of types IgA, IgG, IgE, IgD, IgM and subtypes thereof. In some embodiments, a subject antibody is an IgG isotype.

As used herein the term “immunoglobulin” refers to a protein consisting of one or more polypeptides substantially encoded by immunoglobulin genes. The recognized human immunoglobulin genes include the kappa, lambda, alpha (IgA1 and IgA2), gamma (IgG1, IgG2, IgG3, IgG4), delta, epsilon and mu constant region genes; and numerous immunoglobulin variable region genes. Full-length immunoglobulin light chains (about 25 kD or 214 amino acids) are encoded by a variable region gene at the N-terminus (about 110 amino acids) and a kappa or lambda constant region at the C-terminus. Full-length immunoglobulin heavy chains (about 50 kD or 446 amino acids) are encoded by a variable region gene at the N-terminus (about 116 amino acids) and one of the other aforementioned constant region genes at the C-terminus, e.g. gamma (encoding about 330 amino acids). In some embodiments, a subject antibody comprises full-length immunoglobulin heavy chain and a full-length immunoglobulin light chain.

In some embodiments, a subject antibody does not comprise a full-length immunoglobulin heavy chain and a full-length immunoglobulin light chain, and instead comprises antigen-binding fragments of a full-length immunoglobulin heavy chain and a full-length immunoglobulin light chain. In some embodiments, the antigen-binding fragments are contained on separate polypeptide chains; in other embodiments, the antigen-binding fragments are contained within a single polypeptide chain. The term “antigen-binding fragment” refers to one or more fragments of a full-length antibody that are capable of specifically binding to ACVR2A as described above. Examples of binding fragments include (i) a Fab fragment (a monovalent fragment consisting of the VL, VH, CL and CH1 domains; (ii) a F(ab′)₂ fragment (a bivalent fragment comprising two Fab fragments linked by a disulfide bridge at the hinge region; (iii) a Fd fragment (consisting of the VH and CH1 domains); (iv) a Fv fragment (consisting of the VH and VL domains of a single arm of an antibody); (v) a dAb fragment (consisting of the VH domain); (vi) an isolated CDR; (vii) a single chain Fv (scFv) (consisting of the VH and VL domains of a single arm of an antibody joined by a synthetic linker using recombinant means such that the VH and VL domains pair to form a monovalent molecule); (viii) diabodies (consisting of two scFvs in which the VH and VL domains are joined such that they do not pair to form a monovalent molecule; the VH of each one of the scFv pairs with the VL domain of the other scFv to form a bivalent molecule); (ix) bi-specific antibodies (consisting of at least two antigen binding regions, each region binding a different epitope). In some embodiments, a subject antibody fragment is a Fab fragment. In some embodiments, a subject antibody fragment is a single-chain antibody (scFv).

In some embodiments, a subject antibody is a recombinant or modified antibody, e.g., a chimeric, humanized, deimmunized or an in vitro generated antibody. The term “recombinant” or “modified” antibody as used herein is intended to include all antibodies that are prepared, expressed, created, or isolated by recombinant means, such as (i) antibodies expressed using a recombinant expression vector transfected into a host cell; (ii) antibodies isolated from a recombinant, combinatorial antibody library; (iii) antibodies isolated from an animal (e.g. a mouse) that is transgenic for human immunoglobulin genes; or (iv) antibodies prepared, expressed, created, or isolated by any other means that involves splicing of human immunoglobulin gene sequences to other DNA sequences. Such recombinant antibodies include humanized, CDR grafted, chimeric, deimmunized, and in vitro generated antibodies; and can optionally include constant regions derived from human germline immunoglobulin sequences.

In some embodiments, a subject antibody comprises, in order from N-terminus to C-terminus: a light chain FR1 region; a CDR1; a light chain FR2 region; a CDR2; a light chain FR3 region; a CDR3; optionally a light chain FR4 region; a linker region; optionally a heavy chain FR1 region; a CDR1; a heavy chain FR2 region; a CDR2; a heavy chain FR3 region; a CDR3; and a heavy chain FR4 region. In some of these embodiments, each of the FR regions is a human FR region. The linker region can be from about 5 amino acids to about 50 amino acids in length, e.g., from about 5 aa to about 10 aa, from about 10 aa to about 15 aa, from about 15 aa to about 20 aa, from about 20 aa to about 25 aa, from about 25 aa to about 30 aa, from about 30 aa to about 35 aa, from about 35 aa to about 40 aa, from about 40 aa to about 45 aa, or from about 45 aa to about 50 aa in length.

Linkers suitable for use a subject antibody include “flexible linkers”. If present, the linker molecules are generally of sufficient length to permit some flexible movement between linked regions. The linker molecules are generally about 6-50 atoms long. The linker molecules may also be, for example, aryl acetylene, ethylene glycol oligomers containing 2-10 monomer units, diamines, diacids, amino acids, or combinations thereof. Other linker molecules which can bind to polypeptides may be used in light of this disclosure.

Suitable linkers can be readily selected and can be of any of a suitable of different lengths, such as from 1 amino acid (e.g., Gly) to 20 amino acids, from 2 amino acids to 15 amino acids, from 3 amino acids to 12 amino acids, including 4 amino acids to 10 amino acids, 5 amino acids to 9 amino acids, 6 amino acids to 8 amino acids, or 7 amino acids to 8 amino acids, and may be 1, 2, 3, 4, 5, 6, or 7 amino acids.

Exemplary flexible linkers include glycine polymers (G)_n, glycine-serine polymers (including, for example, (GS)_n, GSGGS_n (SEQ ID NO: 6599) and GGGS_n(SEQ ID NO: 6600), where n is an integer of at least one), glycine-alanine polymers, alanine-serine polymers, and other flexible linkers known in the art. Glycine and glycine-serine polymers are of interest since both of these amino acids are relatively unstructured, and therefore may serve as a neutral tether between components. Glycine polymers are of particular interest since glycine accesses significantly more phi-psi space than even alanine, and is much less restricted than residues with longer side chains (see Scheraga, Rev. Computational Chem. 11173-142 (1992)). Exemplary flexible linkers include, but are not limited GGSG (SEQ ID NO:6601), GGSGG (SEQ ID NO:6602), GSGSG (SEQ ID NO: 6603), GSGGG (SEQ ID NO:6604), GGGSG (SEQ ID NO: 6605), GSSSG (SEQ ID NO: 6606), and the like. The ordinarily skilled artisan will recognize that design of a peptide conjugated to any elements described above can include linkers that are all or partially flexible, such that the linker can include a flexible linker as well as one or more portions that confer less flexible structure.

In some embodiments, a subject antibody is “humanized” The term “humanized antibody” refers to an antibody comprising at least one chain comprising variable region framework residues substantially from a human antibody chain (referred to as the acceptor immunoglobulin or antibody) and at least one CDR substantially from a mouse antibody, (referred to as the donor immunoglobulin or antibody). See, Queen et al., Proc. Natl. Acad. Sci. USA 86:10029 10033 (1989), U.S. Pat. Nos. 5,530,101, 5,585,089, 5,693,761, WO 90/07861, and U.S. Pat. No. 5,225,539. The constant region(s), if present, can also be substantially or entirely from a human immunoglobulin. In some embodiments, a subject antibody may comprise one or more CDRs and one or more FR regions from a human antibody. Methods of making humanized antibodies are known in the art. See, e.g., U.S. Pat. No. 7,256,273.

The substitution of mouse CDRs into a human variable domain framework can result in retention of their correct spatial orientation where, e.g., the human variable domain framework adopts the same or similar conformation to the mouse variable framework from which the CDRs originated. This can be achieved by obtaining the human variable domains from human antibodies whose framework sequences exhibit a high degree of sequence identity with the murine variable framework domains from which the CDRs were derived. The heavy and light chain variable framework regions can be derived from the same or different human antibody sequences. The human antibody sequences can be the sequences of naturally occurring human antibodies or can be consensus sequences of several human antibodies. See Kettleborough et al., Protein Engineering 4:773 (1991); Kolbinger et al., Protein Engineering 6:971 (1993).

Having identified the complementarity determining regions of the murine donor immunoglobulin and appropriate human acceptor immunoglobulins, the next step is to determine which, if any, residues from these components should be substituted to optimize the properties of the resulting humanized antibody. In general, substitution of human amino acid residues with murine should be minimized, because introduction of murine residues increases the risk of the antibody eliciting a human-anti-mouse-antibody (HAMA) response in humans. Art-recognized methods of determining immune response can be performed to monitor a HAMA response in a particular patient or during clinical trials. Patients administered humanized antibodies can be given an immunogenicity assessment at the beginning and throughout the administration of the therapy. The HAMA response is measured, for example, by detecting antibodies to the humanized therapeutic reagent, in serum samples from the patient using a method known to one in the art, including surface plasmon resonance technology (BIACORE) and/or solid-phase ELISA analysis. In many embodiments, a subject humanized antibody does not substantially elicit a HAMA response in a human subject.

Certain amino acids from the human variable region framework residues are selected for substitution based on their possible influence on CDR conformation and/or binding to antigen. The unnatural juxtaposition of murine CDR regions with human variable framework region can result in unnatural conformational restraints, which, unless corrected by substitution of certain amino acid residues, lead to loss of binding affinity.

The selection of amino acid residues for substitution can be determined, in part, by computer modeling. Computer hardware and software for producing three-dimensional images of immunoglobulin molecules are known in the art. In general, molecular models are produced starting from solved structures for immunoglobulin chains or domains thereof. The chains to be modeled are compared for amino acid sequence similarity with chains or domains of solved three-dimensional structures, and the chains or domains showing the greatest sequence similarity is/are selected as starting points for construction of the molecular model. Chains or domains sharing at least 50% sequence identity are selected for modeling, and preferably those sharing at least 60%, 70%, 80%, 90% sequence identity or more are selected for modeling. The solved starting structures are modified to allow for differences between the actual amino acids in the immunoglobulin chains or domains being modeled, and those in the starting structure. The modified structures are then assembled into a composite immunoglobulin. Finally, the model is refined by energy minimization and by verifying that all atoms are within appropriate distances from one another and that bond lengths and angles are within chemically acceptable limits.

CDR and framework regions are as defined by Kabat, Sequences of Proteins of Immunological Interest (National Institutes of Health, Bethesda, Md., 1987 and 1991). An alternative structural definition has been proposed by Chothia et al., J. Mol. Biol. 196:901 (1987); Nature 342:878 (1989); and J. Mol. Biol. 186:651 (1989) (collectively referred to as “Chothia”). When framework residues, as defined by Kabat, supra, constitute structural loop residues as defined by Chothia, supra, the amino acids present in the mouse antibody may be selected for substitution into the humanized antibody. Residues which are “adjacent to a CDR region” include amino acid residues in positions immediately adjacent to one or more of the CDRs in the primary sequence of the humanized immunoglobulin chain, for example, in positions immediately adjacent to a CDR as defined by Kabat, or a CDR as defined by Chothia (See e.g., Chothia and Lesk JMB 196:901 (1987)). These amino acids are particularly likely to interact with the amino acids in the CDRs and, if chosen from the acceptor, to distort the donor CDRs and reduce affinity. Moreover, the adjacent amino acids may interact directly with the antigen (Amit et al., Science, 233:747 (1986)) and selecting these amino acids from the donor may be desirable to keep all the antigen contacts that provide affinity in the original antibody.

In some embodiments, a subject antibody comprises scFv multimers. For example, in some embodiments, a subject antibody is an scFv dimer (e.g., comprises two tandem scFv (scFv₂)), an scFv trimer (e.g., comprises three tandem scFv (scFv₃)), an scFv tetramer (e.g., comprises four tandem scFv (scFv₄)), or is a multimer of more than four scFv (e.g., in tandem). The scFv monomers can be linked in tandem via linkers of from about 2 amino acids to about 10 amino acids in length, e.g., 2 aa, 3 aa, 4 aa, 5 aa, 6 aa, 7 aa, 8 aa, 9 aa, or 10 aa in length. Suitable linkers include, e.g., (Gly)_x, where x is an integer from 2 to 10. Other suitable linkers are those discussed above. In some embodiments, each of the scFv monomers in a subject scFV multimer is humanized, as described above.

In some embodiments, a subject antibody comprises a constant region of an immunoglobulin (e.g., an Fc region). The Fc region, if present, can be a human Fc region. If constant regions are present, the antibody can contain both light chain and heavy chain constant regions. Suitable heavy chain constant region include CH1, hinge, CH2, CH3, and CH4 regions. The antibodies described herein include antibodies having all types of constant regions, including IgM, IgG, IgD, IgA and IgE, and any isotype, including IgG1, IgG2, IgG3 and IgG4. An example of a suitable heavy chain Fc region is a human isotype IgG1 Fc. Light chain constant regions can be lambda or kappa. A subject antibody (e.g., a subject humanized antibody) can comprise sequences from more than one class or isotype. Antibodies can be expressed as tetramers containing two light and two heavy chains, as separate heavy chains, light chains, as Fab, Fab′ F(ab′)2, and Fv, or as single chain antibodies in which heavy and light chain variable domains are linked through a spacer.

In some embodiments, a subject antibody comprises a free thiol (—SH) group at the carboxyl terminus, where the free thiol group can be used to attach the antibody to a second polypeptide (e.g., another antibody, including a subject antibody), a scaffold, a carrier, etc.

In some embodiments, a subject antibody comprises one or more non-naturally occurring amino acids. In some embodiments, the non-naturally encoded amino acid comprises a carbonyl group, an acetyl group, an aminooxy group, a hydrazine group, a hydrazide group, a semicarbazide group, an azide group, or an alkyne group. See, e.g., U.S. Pat. No. 7,632,924 for suitable non-naturally occurring amino acids. Inclusion of a non-naturally occurring amino acid can provide for linkage to a polymer, a second polypeptide, a scaffold, etc. For example, a subject antibody linked to a water-soluble polymer can be made by reacting a water-soluble polymer (e.g., PEG) that comprises a carbonyl group to an the subject antibody that comprises a non-naturally encoded amino acid that comprises an aminooxy, hydrazine, hydrazide or semicarbazide group. As another example, a subject antibody linked to a water-soluble polymer can be made by reacting a subject antibody that comprises an alkyne-containing amino acid with a water-soluble polymer (e.g., PEG) that comprises an azide moiety; in some embodiments, the azide or alkyne group is linked to the PEG molecule through an amide linkage. A “non-naturally encoded amino acid” refers to an amino acid that is not one of the 20 common amino acids or pyrolysine or selenocysteine. Other terms that may be used synonymously with the term “non-naturally encoded amino acid” are “non-natural amino acid,” “unnatural amino acid,” “non-naturally-occurring amino acid,” and variously hyphenated and non-hyphenated versions thereof. The term “non-naturally encoded amino acid” also includes, but is not limited to, amino acids that occur by modification (e.g. post-translational modifications) of a naturally encoded amino acid (including but not limited to, the 20 common amino acids or pyrolysine and selenocysteine) but are not themselves naturally incorporated into a growing polypeptide chain by the translation complex. Examples of such non-naturally-occurring amino acids include, but are not limited to, N-acetylglucosaminyl-L-serine, N-acetylglucosaminyl-L-threonine, and O-phosphotyrosine.

In some embodiments, a subject antibody is linked (e.g., covalently linked) to a polymer (e.g., a polymer other than a polypeptide). Suitable polymers include, e.g., biocompatible polymers, and water-soluble biocompatible polymers. Suitable polymers include synthetic polymers and naturally-occurring polymers. Suitable polymers include, e.g., substituted or unsubstituted straight or branched chain polyalkylene, polyalkenylene or polyoxyalkylene polymers or branched or unbranched polysaccharides, e.g. a homo- or hetero-polysaccharide. Suitable polymers include, e.g., ethylene vinyl alcohol copolymer (commonly known by the generic name EVOH or by the trade name EVAL); polybutylmethacrylate; poly(hydroxyvalerate); poly(L-lactic acid); polycaprolactone; poly(lactide-co-glycolide); poly(hydroxybutyrate); poly(hydroxybutyrate-co-valerate); polydioxanone; polyorthoester; polyanhydride; poly(glycolic acid); poly(D,L-lactic acid); poly(glycolic acid-co-trimethylene carbonate); polyphosphoester; polyphosphoester urethane; poly(amino acids); cyanoacrylates; poly(trimethylene carbonate); poly(iminocarbonate); copoly(ether-esters) (e.g., poly(ethylene oxide)-poly(lactic acid) (PEO/PLA) co-polymers); polyalkylene oxalates; polyphosphazenes; biomolecules, such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid; polyurethanes; silicones; polyesters; polyolefins; polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; polyoxymethylenes; polyimides; polyethers; epoxy resins; polyurethanes; rayon; rayon-triacetate; cellulose; cellulose acetate; cellulose butyrate; cellulose acetate butyrate; cellophane; cellulose nitrate; cellulose propionate; cellulose ethers; amorphous Teflon; poly(ethylene glycol); and carboxymethyl cellulose.

Suitable synthetic polymers include unsubstituted and substituted straight or branched chain poly(ethyleneglycol), poly(propyleneglycol) poly(vinylalcohol), and derivatives thereof, e.g., substituted poly(ethyleneglycol) such as methoxypoly(ethyleneglycol), and derivatives thereof. Suitable naturally-occurring polymers include, e.g., albumin, amylose, dextran, glycogen, and derivatives thereof.

Suitable polymers can have an average molecular weight in a range of from 500 Da to 50000 Da, e.g., from 5000 Da to 40000 Da, or from 25000 to 40000 Da. For example, in some embodiments, where a subject antibody comprises a poly(ethylene glycol) (PEG) or methoxypoly(ethyleneglycol) polymer, the PEG or methoxypoly(ethyleneglycol) polymer can have a molecular weight in a range of from about 0.5 kiloDaltons (kDa) to 1 kDa, from about 1 kDa to 5 kDa, from 5 kDa to 10 kDa, from 10 kDa to 25 kDa, from 25 kDa to 40 kDa, or from 40 kDa to 60 kDa.

As noted above, in some embodiments, a subject antibody is covalently linked to a PEG polymer. In some embodiments, a subject scFv multimer is covalently linked to a PEG polymer. See, e.g., Albrecht et al. (2006) J. Immunol. Methods 310:100. Methods and reagents suitable for PEGylation of a protein are well known in the art and may be found in, e.g., U.S. Pat. No. 5,849,860. PEG suitable for conjugation to a protein is generally soluble in water at room temperature, and has the general formula R(O—CH₂—CH₂)_nO—R, where R is hydrogen or a protective group such as an alkyl or an alkanol group, and where n is an integer from 1 to 1000. Where R is a protective group, it generally has from 1 to 8 carbons.

The PEG conjugated to the subject antibody can be linear. The PEG conjugated to the subject protein may also be branched. Branched PEG derivatives such as those described in U.S. Pat. No. 5,643,575, “star-PEG's” and multi-armed PEG's such as those described in Shearwater Polymers, Inc. catalog “Polyethylene Glycol Derivatives 1997-1998.” Star PEGs are described in the art including, e.g., in U.S. Pat. No. 6,046,305.

A subject antibody can be glycosylated, e.g., comprise a covalently linked carbohydrate or polysaccharide moiety. Glycosylation of antibodies is typically either N-linked or O-linked. N-linked refers to the attachment of the carbohydrate moiety to the side chain of an asparagine residue. The tripeptide sequences asparagine-X-serine and asparagine-X-threonine, where X is any amino acid except proline, are the recognition sequences for enzymatic attachment of the carbohydrate moiety to the asparagine side chain. Thus, the presence of either of these tripeptide sequences in a polypeptide creates a potential glycosylation site. O-linked glycosylation refers to the attachment of one of the sugars N-acetylgalactosamine, galactose, or xylose to a hydroxyamino acid, most commonly serine or threonine, although 5-hydroxyproline or 5-hydroxylysine may also be used.

Addition of glycosylation sites to an antibody is conveniently accomplished by altering the amino acid sequence such that it contains one or more of the above-described tripeptide sequences (for N-linked glycosylation sites). The alteration may also be made by the addition of, or substitution by, one or more serine or threonine residues to the sequence of the original antibody (for O-linked glycosylation sites). Similarly, removal of glycosylation sites can be accomplished by amino acid alteration within the native glycosylation sites of an antibody.

A subject antibody will in some embodiments comprise a “radiopaque” label, e.g. a label that can be easily visualized using for example x-rays. Radiopaque materials are well known to those of skill in the art. The most common radiopaque materials include iodide, bromide or barium salts. Other radiopaque materials are also known and include, but are not limited to organic bismuth derivatives (see, e.g., U.S. Pat. No. 5,939,045), radiopaque multiurethanes (see U.S. Pat. No. 5,346,981), organobismuth composites (see, e.g., U.S. Pat. No. 5,256,334), radiopaque barium multimer complexes (see, e.g., U.S. Pat. No. 4,866,132), and the like.

A subject antibody can be covalently linked to a second moiety (e.g., a lipid, a polypeptide other than a subject antibody, a synthetic polymer, a carbohydrate, and the like) using for example, glutaraldehyde, a homobifunctional cross-linker, or a heterobifunctional cross-linker. Glutaraldehyde cross-links polypeptides via their amino moieties. Homobifunctional cross-linkers (e.g., a homobifunctional imidoester, a homobifunctional N-hydroxysuccinimidyl (NHS) ester, or a homobifunctional sulfhydryl reactive cross-linker) contain two or more identical reactive moieties and can be used in a one step reaction procedure in which the cross-linker is added to a solution containing a mixture of the polypeptides to be linked. Homobifunctional NHS ester and imido esters cross-link amine containing polypeptides. In a mild alkaline pH, imido esters react only with primary amines to form imidoamides, and overall charge of the cross-linked polypeptides is not affected. Homobifunctional sulfhydryl reactive cross-linkers includes bismaleimidhexane (BMH), 1,5-difluoro-2,4-dinitrobenzene (DFDNB), and 1,4-di-(3′,2′-pyridyldithio) propinoamido butane (DPDPB).

Heterobifunctional cross-linkers have two or more different reactive moieties (e.g., amine reactive moiety and a sulfhydryl-reactive moiety) and are cross-linked with one of the polypeptides via the amine or sulfhydryl reactive moiety, then reacted with the other polypeptide via the non-reacted moiety. Multiple heterobifunctional haloacetyl cross-linkers are available, as are pyridyl disulfide cross-linkers. Carbodiimides are a classic example of heterobifunctional cross-linking reagents for coupling carboxyls to amines, which results in an amide bond.

A subject antibody can be immobilized on a solid support. Suitable supports are well known in the art and comprise, inter alia, commercially available column materials, polystyrene beads, latex beads, magnetic beads, colloid metal particles, glass and/or silicon chips and surfaces, nitrocellulose strips, nylon membranes, sheets, duracytes, wells of reaction trays (e.g., multi-well plates), plastic tubes, etc. A solid support can comprise any of a variety of substances, including, e.g., glass, polystyrene, polyvinyl chloride, polypropylene, polyethylene, polycarbonate, dextran, nylon, amylose, natural and modified celluloses, polyacrylamides, agaroses, and magnetite. Suitable methods for immobilizing a subject antibody onto a solid support are well known and include, but are not limited to ionic, hydrophobic, covalent interactions and the like. Solid supports can be soluble or insoluble, e.g., in aqueous solution. In some embodiments, a suitable solid support is generally insoluble in an aqueous solution.

A subject antibody will in some embodiments comprise a detectable label. Suitable detectable labels include any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means. Suitable include, but are not limited to, magnetic beads (e.g. Dynabeads™), fluorescent dyes (e.g., fluorescein isothiocyanate, texas red, rhodamine, a green fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, and the like), radiolabels (e.g., ³H, ¹²⁵I ³⁵S, ¹⁴C, or ³²P), enzymes (e.g., horse radish peroxidase, alkaline phosphatase, luciferase, and others commonly used in an enzyme-linked immunosorbent assay (ELISA)), and colorimetric labels such as colloidal gold or colored glass or plastic (e.g. polystyrene, polypropylene, latex, etc.) beads.

In some embodiments, a subject antibody comprises a contrast agent or a radioisotope, where the contrast agent or radioisotope is one that is suitable for use in imaging, e.g., imaging procedures carried out on humans. Non-limiting examples of labels include radioisotope such as ¹²³¹I (iodine), ¹⁸F (fluorine), ⁹⁹Tc (technetium), ¹¹¹In (indium), and ⁶⁷Ga (gallium), and contrast agent such as gadolinium (Gd), dysprosium, and iron. Radioactive Gd isotopes (¹⁵³Gd) also are available and suitable for imaging procedures in non-human mammals. A subject antibody can be labeled using standard techniques. For example, a subject antibody can be iodinated using chloramine T or 1,3,4,6-tetrachloro-3α,6α-dephenylglycouril. For fluorination, fluorine is added to a subject antibody during the synthesis by a fluoride ion displacement reaction. See, Muller-Gartner, H., TIB Tech., 16:122-130 (1998) and Saji, H., Crit. Rev. Ther. Drug Carrier Syst., 16(2):209-244 (1999) for a review of synthesis of proteins with such radioisotopes. A subject antibody can also be labeled with a contrast agent through standard techniques. For example, a subject antibody can be labeled with Gd by conjugating low molecular Gd chelates such as Gd diethylene triamine pentaacetic acid (GdDTPA) or Gd tetraazacyclododecanetetraacetic (GdDOTA) to the antibody. See, Caravan et al., Chem. Rev. 99:2293-2352 (1999) and Lauffer et al., J. Magn. Reson. Imaging, 3:11-16 (1985). A subject antibody can be labeled with Gd by, for example, conjugating polylysine-Gd chelates to the antibody. See, for example, Curtet et al., Invest. Radiol., 33(10):752-761 (1998). Alternatively, a subject antibody can be labeled with Gd by incubating paramagnetic polymerized liposomes that include Gd chelator lipid with avidin and biotinylated antibody. See, for example, Sipkins et al., Nature Med., 4:623-626 (1998).

Suitable fluorescent proteins that can be linked to a subject antibody include, but are not limited to, a green fluorescent protein from Aequoria victoria or a mutant or derivative thereof e.g., as described in U.S. Pat. Nos. 6,066,476; 6,020,192; 5,985,577; 5,976,796; 5,968,750; 5,968,738; 5,958,713; 5,919,445; 5,874,304; e.g., Enhanced GFP, many such GFP which are available commercially, e.g., from Clontech, Inc.; a red fluorescent protein; a yellow fluorescent protein; any of a variety of fluorescent and colored proteins from Anthozoan species, as described in, e.g., Matz et al. (1999) Nature Biotechnol. 17:969-973; and the like.

A subject antibody will in some embodiments be linked to (e.g., covalently or non-covalently linked) a fusion partner, e.g., a ligand; an epitope tag; a peptide; a protein other than an antibody; and the like. Suitable fusion partners include peptides and polypeptides that confer enhanced stability in vivo (e.g., enhanced serum half-life); provide ease of purification, e.g., (His)_n, e.g., 6His, and the like; provide for secretion of the fusion protein from a cell; provide an epitope tag, e.g., GST, hemagglutinin (HA; e.g., CYPYDVPDYA; SEQ ID NO:6607), FLAG (e.g., DYKDDDDK; SEQ ID NO:6608), c-myc (e.g., CEQKLISEEDL; SEQ ID NO:6609), and the like; provide a detectable signal, e.g., an enzyme that generates a detectable product (e.g., β-galactosidase, luciferase), or a protein that is itself detectable, e.g., a green fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, etc.; provides for multimerization, e.g., a multimerization domain such as an Fc portion of an immunoglobulin; and the like.

The fusion may also include an affinity domain, including peptide sequences that can interact with a binding partner, e.g., such as one immobilized on a solid support, useful for identification or purification. Consecutive single amino acids, such as histidine, when fused to a protein, can be used for one-step purification of the fusion protein by high affinity binding to a resin column, such as nickel sepharose. Exemplary affinity domains include His5 (HHHHH) (SEQ ID NO:6610), HisX6 (HHHHHH) (SEQ ID NO:6611), C-myc (EQKLISEEDL) (SEQ ID NO:6612), Flag (DYKDDDDK) (SEQ ID NO:6608), StrepTag (WSHPQFEK) (SEQ ID NO:6613), hemagglutinin, e.g., HA Tag (YPYDVPDYA; SEQ ID NO:6614), glutathinone-S-transferase (GST), thioredoxin, cellulose binding domain, RYIRS (SEQ ID NO:6615), Phe-His-His-Thr (SEQ ID NO:6616), chitin binding domain, S-peptide, T7 peptide, SH2 domain, C-end RNA tag, WEAAAREACCRECCARA (SEQ ID NO:6617), metal binding domains, e.g., zinc binding domains or calcium binding domains such as those from calcium-binding proteins, e.g., calmodulin, troponin C, calcineurin B, myosin light chain, recoverin, S-modulin, visinin, VILIP, neurocalcin, hippocalcin, frequenin, caltractin, calpain large-subunit, 5100 proteins, parvalbumin, calbindin D9K, calbindin D28K, and calretinin, inteins, biotin, streptavidin, MyoD, leucine zipper sequences, and maltose binding protein.

A subject antibody will in some embodiments be fused to a polypeptide that binds to an endogenous blood brain barrier (BBB) receptor Linking a subject antibody to a polypeptide that binds to an endogenous BBB receptor facilitates crossing the BBB, e.g., in a subject treatment method (see below) involving administration of a subject antibody to an individual in need thereof. Suitable polypeptides that bind to an endogenous BBB include antibodies, e.g., monoclonal antibodies, or antigen-binding fragments thereof, that specifically bind to an endogenous BBB receptor. Suitable endogenous BBB receptors include, but are not limited to, an insulin receptor, a transferrin receptor, a leptin receptor, a lipoprotein receptor, and an insulin-like growth factor receptor. See, e.g., U.S. Patent Publication No. 2009/0156498.

In some embodiments, a subject antibody comprises a polyamine modification. Polyamine modification of a subject antibody enhances permeability of the modified antibody at the BBB. A subject antibody can be modified with polyamines that are either naturally occurring or synthetic. See, for example, U.S. Pat. No. 5,670,477. Useful naturally occurring polyamines include putrescine, spermidine, spermine, 1,3-deaminopropane, norspermidine, syn-homospermidine, thermine, thermospermine, caldopentamine, homocaldopentamine, and canavalmine. Putrescine, spermidine and spermine are particularly useful. Synthetic polyamines are composed of the empirical formula C_xH_yN_z, can be cyclic or acyclic, branched or unbranched, hydrocarbon chains of 3-12 carbon atoms that further include 1-6 NR or N(R)₂ moieties, wherein R is H, (C₁-C₄) alkyl, phenyl, or benzyl. Polyamines can be linked to an antibody using any standard crosslinking method.

In some embodiments, a subject antibody is modified to include a carbohydrate moiety, where the carbohydrate moiety can be covalently linked to the antibody. In some embodiments, a subject antibody is modified to include a lipid moiety, where the lipid moiety can be covalently linked to the antibody. Suitable lipid moieties include, e.g., an N-fatty acyl group such as N-lauroyl, N-oleoyl, etc.; a fatty amine such as dodecyl amine, oleoyl amine, etc.; a C3-C16 long-chain aliphatic lipid; and the like. See, e.g., U.S. Pat. No. 6,638,513). In some embodiments, a subject antibody is incorporated into a liposome.

Methods of Producing a Subject Antibody

The present antibody can be produced by any known method, e.g., conventional synthetic methods for protein synthesis; recombinant DNA methods; etc.

Where a subject antibody is a single chain polypeptide, it can synthesized using standard chemical peptide synthesis techniques. Where a polypeptide is chemically synthesized, the synthesis may proceed via liquid-phase or solid-phase. Solid phase polypeptide synthesis (SPPS), in which the C-terminal amino acid of the sequence is attached to an insoluble support followed by sequential addition of the remaining amino acids in the sequence, is an example of a suitable method for the chemical synthesis of a subject antibody. Various forms of SPPS, such as Fmoc and Boc, are available for synthesizing a subject antibody. Techniques for solid phase synthesis are described by Barany and Merrifield, Solid-Phase Peptide Synthesis; pp. 3-284 in The Peptides: Analysis, Synthesis, Biology. Vol. 2: Special Methods in Peptide Synthesis, Part A., Merrifield, et al. J. Am. Chem. Soc., 85: 2149-2156 (1963); Stewart et al., Solid Phase Peptide Synthesis, 2nd ed. Pierce Chem. Co., Rockford, Ill. (1984); and Ganesan A. 2006 Mini Rev. Med Chem. 6:3-10 and Camarero J A et al. 2005 Protein Pept Lett. 12:723-8. Briefly, small insoluble, porous beads are treated with functional units on which peptide chains are built. After repeated cycling of coupling/deprotection, the free N-terminal amine of a solid-phase attached is coupled to a single N-protected amino acid unit. This unit is then deprotected, revealing a new N-terminal amine to which a further amino acid may be attached. The peptide remains immobilized on the solid-phase and undergoes a filtration process before being cleaved off.

Standard recombinant methods can be used for production of a subject antibody. For example, nucleic acids encoding light and heavy chain variable regions, optionally linked to constant regions, are inserted into expression vectors. The light and heavy chains can be cloned in the same or different expression vectors. The DNA segments encoding immunoglobulin chains are operably linked to control sequences in the expression vector(s) that ensure the expression of immunoglobulin polypeptides. Expression control sequences include, but are not limited to, promoters (e.g., naturally-associated or heterologous promoters), signal sequences, enhancer elements, and transcription termination sequences. The expression control sequences can be eukaryotic promoter systems in vectors capable of transforming or transfecting eukaryotic host cells (e.g., COS or CHO cells). Once the vector has been incorporated into the appropriate host, the host is maintained under conditions suitable for high level expression of the nucleotide sequences, and the collection and purification of the antibodies.

Because of the degeneracy of the code, a variety of nucleic acid sequences can encode each immunoglobulin amino acid sequence. The desired nucleic acid sequences can be produced by de novo solid-phase DNA synthesis or by polymerase chain reaction (PCR) mutagenesis of an earlier prepared variant of the desired polynucleotide. Oligonucleotide-mediated mutagenesis is an example of a suitable method for preparing substitution, deletion and insertion variants of target polypeptide DNA. See Adelman et al., DNA 2:183 (1983). Briefly, the target polypeptide DNA is altered by hybridizing an oligonucleotide encoding the desired mutation to a single-stranded DNA template. After hybridization, a DNA polymerase is used to synthesize an entire second complementary strand of the template that incorporates the oligonucleotide primer, and encodes the selected alteration in the target polypeptide DNA.

Suitable expression vectors are typically replicable in the host organisms either as episomes or as an integral part of the host chromosomal DNA. Commonly, expression vectors contain selection markers (e.g., ampicillin-resistance, hygromycin-resistance, tetracycline resistance, kanamycin resistance or neomycin resistance) to permit detection of those cells transformed with the desired DNA sequences.

Escherichia coli is an example of a prokaryotic host cell that can be used for cloning a subject antibody-encoding polynucleotide. Other microbial hosts suitable for use include bacilli, such as Bacillus subtilis, and other enterobacteriaceae, such as Salmonella, Serratia, and various Pseudomonas species. In these prokaryotic hosts, one can also make expression vectors, which will typically contain expression control sequences compatible with the host cell (e.g., an origin of replication). In addition, any number of a variety of well-known promoters will be present, such as the lactose promoter system, a tryptophan (trp) promoter system, a beta-lactamase promoter system, or a promoter system from phage lambda. The promoters will typically control expression, optionally with an operator sequence, and have ribosome binding site sequences and the like, for initiating and completing transcription and translation.

Other microbes, such as yeast, are also useful for expression. Saccharomyces (e.g., S. cerevisiae) and Pichia are examples of suitable yeast host cells, with suitable vectors having expression control sequences (e.g., promoters), an origin of replication, termination sequences and the like as desired. Typical promoters include 3-phosphoglycerate kinase and other glycolytic enzymes. Inducible yeast promoters include, among others, promoters from alcohol dehydrogenase, isocytochrome C, and enzymes responsible for maltose and galactose utilization.

In addition to microorganisms, mammalian cells (e.g., mammalian cells grown in in vitro cell culture) can also be used to express and produce the polypeptides of the present invention (e.g., polynucleotides encoding immunoglobulins or fragments thereof). See Winnacker, From Genes to Clones, VCH Publishers, N.Y., N.Y. (1987). Suitable mammalian host cells include CHO cell lines, various Cos cell lines, HeLa cells, myeloma cell lines, and transformed B-cells or hybridomas. Expression vectors for these cells can include expression control sequences, such as an origin of replication, a promoter, and an enhancer (Queen et al., Immunol. Rev. 89:49 (1986)), and necessary processing information sites, such as ribosome binding sites, RNA splice sites, polyadenylation sites, and transcriptional terminator sequences. Examples of suitable expression control sequences are promoters derived from immunoglobulin genes, SV40, adenovirus, bovine papilloma virus, cytomegalovirus and the like. See Co et al., J. Immunol. 148:1149 (1992).

Once synthesized (either chemically or recombinantly), the whole antibodies, their dimers, individual light and heavy chains, or other forms of a subject antibody (e.g., scFv, etc.) can be purified according to standard procedures of the art, including ammonium sulfate precipitation, affinity columns, column chromatography, high performance liquid chromatography (HPLC) purification, gel electrophoresis, and the like (see generally Scopes, Protein Purification (Springer-Verlag, N.Y., (1982)). A subject antibody can be substantially pure, e.g., at least about 80% to 85% pure, at least about 85% to 90% pure, at least about 90% to 95% pure, or 98% to 99%, or more, pure, e.g., free from contaminants such as cell debris, macromolecules other than a subject antibody, etc.

Compositions

The present disclosure provides a composition comprising a subject antibody. A subject antibody composition can comprise, in addition to a subject antibody, one or more of: a salt, e.g., NaCl, MgCl₂, KCl, MgSO₄, etc.; a buffering agent, e.g., a Tris buffer, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid) (HEPES), 2-(N-Morpholino)ethanesulfonic acid (MES), 2-(N-Morpholino)ethanesulfonic acid sodium salt (MES), 3-(N-Morpholino)propanesulfonic acid (MOPS), N-tris[Hydroxymethyl]methyl-3-aminopropanesulfonic acid (TAPS), etc.; a solubilizing agent; a detergent, e.g., a non-ionic detergent such as Tween-20, etc.; a protease inhibitor; glycerol; and the like.

Nucleic Acids

The present disclosure provides nucleic acids comprising nucleotide sequences encoding a subject antibody. A nucleotide sequence encoding a subject antibody can be operably linked to one or more regulatory elements, such as a promoter and enhancer, that allow expression of the nucleotide sequence in the intended target cells (e.g., a cell that is genetically modified to synthesize the encoded antibody).

Suitable promoter and enhancer elements are known in the art. For expression in a bacterial cell, suitable promoters include, but are not limited to, lad, lacZ, T3, T7, gpt, lambda P and trc. For expression in a eukaryotic cell, suitable promoters include, but are not limited to, light and/or heavy chain immunoglobulin gene promoter and enhancer elements; cytomegalovirus immediate early promoter; herpes simplex virus thymidine kinase promoter; early and late SV40 promoters; promoter present in long terminal repeats from a retrovirus; mouse metallothionein-I promoter; and various art-known tissue specific promoters.

In some embodiments, e.g., for expression in a yeast cell, a suitable promoter is a constitutive promoter such as an ADH1 promoter, a PGK1 promoter, an ENO promoter, a PYK1 promoter and the like; or a regulatable promoter such as a GAL1 promoter, a GAL10 promoter, an ADH2 promoter, a PHO5 promoter, a CUP1 promoter, a GAL7 promoter, a MET25 promoter, a MET3 promoter, a CYC1 promoter, a HIS3 promoter, an ADH1 promoter, a PGK promoter, a GAPDH promoter, an ADC1 promoter, a TRP1 promoter, a URA3 promoter, a LEU2 promoter, an ENO promoter, a TP1 promoter, and AOX1 (e.g., for use in Pichia). Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art.

Suitable promoters for use in prokaryotic host cells include, but are not limited to, a bacteriophage T7 RNA polymerase promoter; a trp promoter; a lac operon promoter; a hybrid promoter, e.g., a lac/tac hybrid promoter, a tac/trc hybrid promoter, a trp/lac promoter, a T7/lac promoter; a trc promoter; a tac promoter, and the like; an araBAD promoter; in vivo regulated promoters, such as an ssaG promoter or a related promoter (see, e.g., U.S. Patent Publication No. 20040131637), a pagC promoter (Pulkkinen and Miller, J. Bacteriol., 1991: 173(1): 86-93; Alpuche-Aranda et al., PNAS, 1992; 89(21): 10079-83), a nirB promoter (Harborne et al. (1992) Mol. Micro. 6:2805-2813), and the like (see, e.g., Dunstan et al. (1999) Infect. Immun. 67:5133-5141; McKelvie et al. (2004) Vaccine 22:3243-3255; and Chatfield et al. (1992) Biotechnol. 10:888-892); a sigma70 promoter, e.g., a consensus sigma70 promoter (see, e.g., GenBank Accession Nos. AX798980, AX798961, and AX798183); a stationary phase promoter, e.g., a dps promoter, an spy promoter, and the like; a promoter derived from the pathogenicity island SPI-2 (see, e.g., WO96/17951); an actA promoter (see, e.g., Shetron-Rama et al. (2002) Infect. Immun. 70:1087-1096); an rpsM promoter (see, e.g., Valdivia and Falkow (1996). Mol. Microbiol. 22:367); a tet promoter (see, e.g., Hillen,W. and Wissmann,A. (1989) In Saenger,W. and Heinemann,U. (eds), Topics in Molecular and Structural Biology, Protein—Nucleic Acid Interaction. Macmillan, London, UK, Vol. 10, pp. 143-162); an SP6 promoter (see, e.g., Melton et al. (1984) Nucl. Acids Res. 12:7035); and the like. Suitable strong promoters for use in prokaryotes such as Escherichia coli include, but are not limited to Trc, Tac, T5, T7, and P_Lambda. Non limiting examples of operators for use in bacterial host cells include a lactose promoter operator (Lad repressor protein changes conformation when contacted with lactose, thereby preventing the Lad repressor protein from binding to the operator), a tryptophan promoter operator (when complexed with tryptophan, TrpR repressor protein has a conformation that binds the operator; in the absence of tryptophan, the TrpR repressor protein has a conformation that does not bind to the operator), and a tac promoter operator (see, for example, deBoer et al. (1983) Proc. Natl. Acad. Sci. U.S.A. 80:21-25).

A nucleotide sequence encoding a subject antibody can be present in an expression vector and/or a cloning vector. Where a subject antibody comprises two separate polypeptides, nucleotide sequences encoding the two polypeptides can be cloned in the same or separate vectors. An expression vector can include a selectable marker, an origin of replication, and other features that provide for replication and/or maintenance of the vector.

Large numbers of suitable vectors and promoters are known to those of skill in the art; many are commercially available for generating a subject recombinant constructs. The following vectors are provided by way of example. Bacterial: pBs, phagescript, PsiX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene, La Jolla, Calif., USA); pTrc99A, pKK223-3, pKK233-3, pDR540, and pRIT5 (Pharmacia, Uppsala, Sweden). Eukaryotic: pWLneo, pSV2cat, pOG44, PXR1, pSG (Stratagene) pSVK3, pBPV, pMSG and pSVL (Pharmacia).

Expression vectors generally have convenient restriction sites located near the promoter sequence to provide for the insertion of nucleic acid sequences encoding heterologous proteins. A selectable marker operative in the expression host may be present. Suitable expression vectors include, but are not limited to, viral vectors (e.g. viral vectors based on vaccinia virus; poliovirus; adenovirus (see, e.g., Li et al., Invest Opthalmol Vis Sci 35:2543 2549, 1994; Borras et al., Gene Ther 6:515 524, 1999; Li and Davidson, PNAS 92:7700 7704, 1995; Sakamoto et al., H Gene Ther 5:1088 1097, 1999; WO 94/12649, WO 93/03769; WO 93/19191; WO 94/28938; WO 95/11984 and WO 95/00655); adeno-associated virus (see, e.g., Ali et al., Hum Gene Ther 9:81 86, 1998, Flannery et al., PNAS 94:6916 6921, 1997; Bennett et al., Invest Opthalmol Vis Sci 38:2857 2863, 1997; Jomary et al., Gene Ther 4:683 690, 1997, Rolling et al., Hum Gene Ther 10:641 648, 1999; Ali et al., Hum Mol Genet 5:591 594, 1996; Srivastava in WO 93/09239, Samulski et al., J. Vir. (1989) 63:3822-3828; Mendelson et al., Virol. (1988) 166:154-165; and Flotte et al., PNAS (1993) 90:10613-10617); SV40; herpes simplex virus; human immunodeficiency virus (see, e.g., Miyoshi et al., PNAS 94:10319 23, 1997; Takahashi et al., J Virol 73:7812 7816, 1999); a retroviral vector (e.g., Murine Leukemia Virus, spleen necrosis virus, and vectors derived from retroviruses such as Rous Sarcoma Virus, Harvey Sarcoma Virus, avian leukosis virus, human immunodeficiency virus, myeloproliferative sarcoma virus, and mammary tumor virus); and the like.

As noted above, a subject nucleic acid comprises a nucleotide sequence encoding a subject antibody. A subject nucleic acid can comprise a nucleotide sequence encoding heavy- and light-chain CDRs. In some embodiments, a subject nucleic acid comprises a nucleotide sequence encoding heavy- and light-chain CDRs, where the CDR-encoding sequences are interspersed with FR-encoding nucleotide sequences. In some embodiments, the FR-encoding nucleotide sequences are human FR-encoding nucleotide sequences.

In some embodiments, a subject nucleic acid comprises a nucleotide sequence having at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 98%, at least about 99%, or 100%, nucleotide sequence identity to the nucleotide sequence set forth in herein. In some embodiments, a subject nucleic acid comprises a nucleotide sequence having at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 98%, at least about 99%, or 100%, nucleotide sequence identity to the nucleotide sequence set forth in herein.

Cells

The present disclosure provides isolated genetically modified host cells (e.g., in vitro cells) that are genetically modified with a subject nucleic acid. In some embodiments, a subject isolated genetically modified host cell can produce a subject antibody.

Suitable host cells include eukaryotic host cells, such as a mammalian cell, an insect host cell, a yeast cell; and prokaryotic cells, such as a bacterial cell. Introduction of a subject nucleic acid into the host cell can be effected, for example by calcium phosphate precipitation, DEAE dextran mediated transfection, liposome-mediated transfection, electroporation, or other known method.

Suitable mammalian cells include primary cells and immortalized cell lines. Suitable mammalian cell lines include human cell lines, non-human primate cell lines, rodent (e.g., mouse, rat) cell lines, and the like. Suitable mammalian cell lines include, but are not limited to, HeLa cells (e.g., American Type Culture Collection (ATCC) No. CCL-2), CHO cells (e.g., ATCC Nos. CRL9618, CCL61, CRL9096), 293 cells (e.g., ATCC No. CRL-1573), Vero cells, NIH 3T3 cells (e.g., ATCC No. CRL-1658), Huh-7 cells, BHK cells (e.g., ATCC No. CCL10), PC12 cells (ATCC No. CRL1721), COS cells, COS-7 cells (ATCC No. CRL1651), RAT1 cells, mouse L cells (ATCC No. CCLI.3), human embryonic kidney (HEK) cells (ATCC No. CRL1573), HLHepG2 cells, and the like.

Suitable yeast cells include, but are not limited to, Pichia pastoris, Pichia finlandica, Pichia trehalophila, Pichia koclamae, Pichia membranaefaciens, Pichia opuntiae, Pichia thermotolerans, Pichia salictaria, Pichia guercuum, Pichia pijperi, Pichia stiptis, Pichia methanolica, Pichia sp., Saccharomyces cerevisiae, Saccharomyces sp., Hansenula polymorpha, Kluyveromyces sp., Kluyveromyces lactis, Candida albicans, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Trichoderma reesei, Chrysosporium lucknowense, Fusarium sp., Fusarium gramineum, Fusarium venenatum, Neurospora crassa, Chlamydomonas reinhardtii, and the like.

Suitable prokaryotic cells include, but are not limited to, any of a variety of laboratory strains of Escherichia coli, Lactobacillus sp., Salmonella sp., Shigella sp., and the like. See, e.g., Carrier et al. (1992) J. Immunol. 148:1176-1181; U.S. Pat. No. 6,447,784; and Sizemore et al. (1995) Science 270:299-302. Examples of Salmonella strains which can be employed in the present invention include, but are not limited to, Salmonella typhi and S. typhimurium. Suitable Shigella strains include, but are not limited to, Shigella flexneri, Shigella sonnei, and Shigella disenteriae. Typically, the laboratory strain is one that is non-pathogenic. Non-limiting examples of other suitable bacteria include, but are not limited to, Bacillus subtilis, Pseudomonas pudita, Pseudomonas aeruginosa, Pseudomonas mevalonii, Rhodobacter sphaeroides, Rhodobacter capsulatus, Rhodospirillum rubrum, Rhodococcus sp., and the like. In some embodiments, the host cell is Escherichia coli.

Compositions

The present disclosure provides compositions, including pharmaceutical compositions, comprising a subject antibody. In general, a formulation comprises an effective amount of a subject antibody. An “effective amount” means a dosage sufficient to produce a desired result, e.g., an increase of muscle mass or amelioration of a symptom of a disease. Generally, the desired result is at least a reduction in a symptom of an ACVR2A-associated conditino, as compared to a control. A subject antibody can be delivered in such a manner as to avoid the blood-brain barrier, as described in more detail below. A subject antibody can be formulated and/or modified to enable the antibody to cross the blood-brain barrier.

Formulations

In the subject methods, a subject antibody can be administered to the host using any convenient means capable of resulting in the desired therapeutic effect or diagnostic effect. Thus, the agent can be incorporated into a variety of formulations for therapeutic administration. More particularly, a subject antibody can be formulated into pharmaceutical compositions by combination with appropriate, pharmaceutically acceptable carriers or diluents, and may be formulated into preparations in solid, semi-solid, liquid or gaseous forms, such as tablets, capsules, powders, granules, ointments, solutions, suppositories, injections, inhalants and aerosols.

In pharmaceutical dosage forms, a subject antibody can be administered in the form of their pharmaceutically acceptable salts, or they may also be used alone or in appropriate association, as well as in combination, with other pharmaceutically active compounds. The following methods and excipients are merely exemplary and are in no way limiting.

For oral preparations, a subject antibody can be used alone or in combination with appropriate additives to make tablets, powders, granules or capsules, for example, with conventional additives, such as lactose, mannitol, corn starch or potato starch; with binders, such as crystalline cellulose, cellulose derivatives, acacia, corn starch or gelatins; with disintegrators, such as corn starch, potato starch or sodium carboxymethylcellulose; with lubricants, such as talc or magnesium stearate; and if desired, with diluents, buffering agents, moistening agents, preservatives and flavoring agents.

A subject antibody can be formulated into preparations for injection by dissolving, suspending or emulsifying them in an aqueous or nonaqueous solvent, such as vegetable or other similar oils, synthetic aliphatic acid glycerides, esters of higher aliphatic acids or propylene glycol; and if desired, with conventional additives such as solubilizers, isotonic agents, suspending agents, emulsifying agents, stabilizers and preservatives.

Pharmaceutical compositions comprising a subject antibody are prepared by mixing the antibody having the desired degree of purity with optional physiologically acceptable carriers, excipients, stabilizers, surfactants, buffers and/or tonicity agents. Acceptable carriers, excipients and/or stabilizers are nontoxic to recipients at the dosages and concentrations employed, and include buffers such as phosphate, citrate, and other organic acids; antioxidants including ascorbic acid, glutathione, cysteine, methionine and citric acid; preservatives (such as ethanol, benzyl alcohol, phenol, m-cresol, p-chlor-m-cresol, methyl or propyl parabens, benzalkonium chloride, or combinations thereof); amino acids such as arginine, glycine, ornithine, lysine, histidine, glutamic acid, aspartic acid, isoleucine, leucine, alanine, phenylalanine, tyrosine, tryptophan, methionine, serine, proline and combinations thereof; monosaccharides, disaccharides and other carbohydrates; low molecular weight (less than about 10 residues) polypeptides; proteins, such as gelatin or serum albumin; chelating agents such as EDTA; sugars such as trehalose, sucrose, lactose, glucose, mannose, maltose, galactose, fructose, sorbose, raffinose, glucosamine, N-methylglucosamine, galactosamine, and neuraminic acid; and/or non-ionic surfactants such as Tween, Brij Pluronics, Triton-X, or polyethylene glycol (PEG).

The pharmaceutical composition may be in a liquid form, a lyophilized form or a liquid form reconstituted from a lyophilized form, wherein the lyophilized preparation is to be reconstituted with a sterile solution prior to administration. The standard procedure for reconstituting a lyophilized composition is to add back a volume of pure water (typically equivalent to the volume removed during lyophilization); however solutions comprising antibacterial agents may be used for the production of pharmaceutical compositions for parenteral administration; see also Chen (1992) Drug Dev Ind Pharm 18, 1311-54.

Exemplary antibody concentrations in a subject pharmaceutical composition may range from about 1 mg/mL to about 200 mg/ml or from about 50 mg/mL to about 200 mg/mL, or from about 150 mg/mL to about 200 mg/mL.

An aqueous formulation of the antibody may be prepared in a pH-buffered solution, e.g., at pH ranging from about 4.0 to about 7.0, or from about 5.0 to about 6.0, or alternatively about 5.5. Examples of buffers that are suitable for a pH within this range include phosphate-, histidine-, citrate-, succinate-, acetate-buffers and other organic acid buffers. The buffer concentration can be from about 1 mM to about 100 mM, or from about 5 mM to about 50 mM, depending, e.g., on the buffer and the desired tonicity of the formulation.

A tonicity agent may be included in the antibody formulation to modulate the tonicity of the formulation. Exemplary tonicity agents include sodium chloride, potassium chloride, glycerin and any component from the group of amino acids, sugars as well as combinations thereof. In some embodiments, the aqueous formulation is isotonic, although hypertonic or hypotonic solutions may be suitable. The term “isotonic” denotes a solution having the same tonicity as some other solution with which it is compared, such as physiological salt solution or serum. Tonicity agents may be used in an amount of about 5 mM to about 350 mM, e.g., in an amount of 100 mM to 350 nM.

A surfactant may also be added to the antibody formulation to reduce aggregation of the formulated antibody and/or minimize the formation of particulates in the formulation and/or reduce adsorption. Exemplary surfactants include polyoxyethylensorbitan fatty acid esters (Tween), polyoxyethylene alkyl ethers (Brij), alkylphenylpolyoxyethylene ethers (Triton-X), polyoxyethylene-polyoxypropylene copolymer (Poloxamer, Pluronic), and sodium dodecyl sulfate (SDS). Examples of suitable polyoxyethylenesorbitan-fatty acid esters are polysorbate 20, (sold under the trademark Tween 20™) and polysorbate 80 (sold under the trademark Tween 80™). Examples of suitable polyethylene-polypropylene copolymers are those sold under the names Pluronic® F68 or Poloxamer 188™. Examples of suitable Polyoxyethylene alkyl ethers are those sold under the trademark Brij™. Exemplary concentrations of surfactant may range from about 0.001% to about 1% w/v.

A lyoprotectant may also be added in order to protect the labile active ingredient (e.g. a protein) against destabilizing conditions during the lyophilization process. For example, known lyoprotectants include sugars (including glucose and sucrose); polyols (including mannitol, sorbitol and glycerol); and amino acids (including alanine, glycine and glutamic acid). Lyoprotectants can be included in an amount of about 10 mM to 500 nM.

In some embodiments, a subject formulation includes a subject antibody, and one or more of the above-identified agents (e.g., a surfactant, a buffer, a stabilizer, a tonicity agent) and is essentially free of one or more preservatives, such as ethanol, benzyl alcohol, phenol, m-cresol, p-chlor-m-cresol, methyl or propyl parabens, benzalkonium chloride, and combinations thereof. In other embodiments, a preservative is included in the formulation, e.g., at concentrations ranging from about 0.001 to about 2% (w/v).

For example, a subject formulation can be a liquid or lyophilized formulation suitable for parenteral administration, and can comprise: about 1 mg/mL to about 200 mg/mL of a subject antibody; about 0.001% to about 1% of at least one surfactant; about 1 mM to about 100 mM of a buffer; optionally about 10 mM to about 500 mM of a stabilizer; and about 5 mM to about 305 mM of a tonicity agent; and has a pH of about 4.0 to about 7.0.

As another example, a subject parenteral formulation is a liquid or lyophilized formulation comprising: about 1 mg/mL to about 200 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM Sucrose; and has a pH of 5.5.

As another example, a subject parenteral formulation comprises a lyophilized formulation comprising: 1) 15 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM sucrose; and has a pH of 5.5; or 2) 75 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM sucrose; and has a pH of 5.5; or 3) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM Sucrose; and has a pH of 5.5; or 4) 75 mg/mL of a subject antibody; 0.04% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5; or 6) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5.

As another example, a subject parenteral formulation is a liquid formulation comprising: 1) 7.5 mg/mL of a subject antibody; 0.022% Tween 20 w/v; 120 mM L-histidine; and 250 125 mM sucrose; and has a pH of 5.5; or 2) 37.5 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 10 mM L-histidine; and 125 mM sucrose; and has a pH of 5.5; or 3) 37.5 mg/mL of a subject antibody; 0.01% Tween 20 w/v; 10 mM L-histidine; and 125 mM sucrose; and has a pH of 5.5; or 4) 37.5 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 10 mM L-histidine; 125 mM trehalose; and has a pH of 5.5; or 5) 37.5 mg/mL of a subject antibody; 0.01% Tween 20 w/v; 10 mM L-histidine; and 125 mM trehalose; and has a pH of 5.5; or 6) 5 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5; or 7) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM mannitol; and has a pH of 5.5; or 8) 75 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L histidine; and 140 mM sodium chloride; and has a pH of 5.5; or 9) 150 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM trehalose; and has a pH of 5.5; or 10) 150 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 250 mM mannitol; and has a pH of 5.5; or 11) 150 mg/mL of a subject antibody; 0.02% Tween 20 w/v; 20 mM L-histidine; and 140 mM sodium chloride; and has a pH of 5.5; or 12) 10 mg/mL of a subject antibody; 0.01% Tween 20 w/v; 20 mM L-histidine; and 40 mM sodium chloride; and has a pH of 5.5.

A subject antibody can be utilized in aerosol formulation to be administered via inhalation. A subject antibody can be formulated into pressurized acceptable propellants such as dichlorodifluoromethane, propane, nitrogen and the like.

Furthermore, a subject antibody can be made into suppositories by mixing with a variety of bases such as emulsifying bases or water-soluble bases. A subject antibody can be administered rectally via a suppository. The suppository can include vehicles such as cocoa butter, carbowaxes and polyethylene glycols, which melt at body temperature, yet are solidified at room temperature.

Unit dosage forms for oral or rectal administration such as syrups, elixirs, and suspensions may be provided wherein each dosage unit, for example, teaspoonful, tablespoonful, tablet or suppository, contains a predetermined amount of the composition containing one or more inhibitors. Similarly, unit dosage forms for injection or intravenous administration may comprise a subject antibody in a composition as a solution in sterile water, normal saline or another pharmaceutically acceptable carrier.

The term “unit dosage form,” as used herein, refers to physically discrete units suitable as unitary dosages for human and animal subjects, each unit containing a predetermined quantity of compounds of the present invention calculated in an amount sufficient to produce the desired effect in association with a pharmaceutically acceptable diluent, carrier or vehicle. The specifications for a subject antibody may depend on the particular antibody employed and the effect to be achieved, and the pharmacodynamics associated with each antibody in the host.

Other modes of administration will also find use with the subject invention. For instance, a subject antibody can be formulated in suppositories and, in some cases, aerosol and intranasal compositions. For suppositories, the vehicle composition will include traditional binders and carriers such as, polyalkylene glycols, or triglycerides. Such suppositories may be formed from mixtures containing the active ingredient in the range of about 0.5% to about 10% (w/w), e.g., about 1% to about 2%.

Intranasal formulations will usually include vehicles that neither cause irritation to the nasal mucosa nor significantly disturb ciliary function. Diluents such as water, aqueous saline or other known substances can be employed with the subject invention. The nasal formulations may also contain preservatives such as, but not limited to, chlorobutanol and benzalkonium chloride. A surfactant may be present to enhance absorption of the subject proteins by the nasal mucosa.

A subject antibody can be administered as an injectable formulation. Typically, injectable compositions are prepared as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. The preparation may also be emulsified or the antibody encapsulated in liposome vehicles.

Suitable excipient vehicles are, for example, water, saline, dextrose, glycerol, ethanol, or the like, and combinations thereof. In addition, if desired, the vehicle may contain minor amounts of auxiliary substances such as wetting or emulsifying agents or pH buffering agents. Actual methods of preparing such dosage forms are known, or will be apparent, to those skilled in the art. See, e.g., Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pa., 17th edition, 1985. The composition or formulation to be administered will, in any event, contain a quantity of a subject antibody adequate to achieve the desired state in the subject being treated.

The pharmaceutically acceptable excipients, such as vehicles, adjuvants, carriers or diluents, are readily available to the public. Moreover, pharmaceutically acceptable auxiliary substances, such as pH adjusting and buffering agents, tonicity adjusting agents, stabilizers, wetting agents and the like, are readily available to the public.

In some embodiments, a subject antibody is formulated in a controlled release formulation. Sustained-release preparations may be prepared using methods well known in the art. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing the antibody in which the matrices are in the form of shaped articles, e.g. films or microcapsules. Examples of sustained-release matrices include polyesters, copolymers of L-glutamic acid and ethyl-L-glutamate, non-degradable ethylene-vinyl acetate, hydrogels, polylactides, degradable lactic acid-glycolic acid copolymers and poly-D-(−)-3-hydroxybutyric acid. Possible loss of biological activity and possible changes in immunogenicity of antibodies comprised in sustained-release preparations may be prevented by using appropriate additives, by controlling moisture content and by developing specific polymer matrix compositions.

Controlled release within the scope of this invention can be taken to mean any one of a number of extended release dosage forms. The following terms may be considered to be substantially equivalent to controlled release, for the purposes of the present invention: continuous release, controlled release, delayed release, depot, gradual release, long-term release, programmed release, prolonged release, proportionate release, protracted release, repository, retard, slow release, spaced release, sustained release, time coat, timed release, delayed action, extended action, layered-time action, long acting, prolonged action, repeated action, slowing acting, sustained action, sustained-action medications, and extended release. Further discussions of these terms may be found in Lesczek Krowczynski, Extended-Release Dosage Forms, 1987 (CRC Press, Inc.).

The various controlled release technologies cover a very broad spectrum of drug dosage forms. Controlled release technologies include, but are not limited to physical systems and chemical systems.

Physical systems include, but are not limited to, reservoir systems with rate-controlling membranes, such as microencapsulation, macroencapsulation, and membrane systems; reservoir systems without rate-controlling membranes, such as hollow fibers, ultra microporous cellulose triacetate, and porous polymeric substrates and foams; monolithic systems, including those systems physically dissolved in non-porous, polymeric, or elastomeric matrices (e.g., nonerodible, erodible, environmental agent ingression, and degradable), and materials physically dispersed in non-porous, polymeric, or elastomeric matrices (e.g., nonerodible, erodible, environmental agent ingression, and degradable); laminated structures, including reservoir layers chemically similar or dissimilar to outer control layers; and other physical methods, such as osmotic pumps, or adsorption onto ion-exchange resins.

Chemical systems include, but are not limited to, chemical erosion of polymer matrices (e.g., heterogeneous, or homogeneous erosion), or biological erosion of a polymer matrix (e.g., heterogeneous, or homogeneous). Additional discussion of categories of systems for controlled release may be found in Agis F. Kydonieus, Controlled Release Technologies: Methods, Theory and Applications, 1980 (CRC Press, Inc.).

There are a number of controlled release drug formulations that are developed for oral administration. These include, but are not limited to, osmotic pressure-controlled gastrointestinal delivery systems; hydrodynamic pressure-controlled gastrointestinal delivery systems; membrane permeation-controlled gastrointestinal delivery systems, which include microporous membrane permeation-controlled gastrointestinal delivery devices; gastric fluid-resistant intestine targeted controlled-release gastrointestinal delivery devices; gel diffusion-controlled gastrointestinal delivery systems; and ion-exchange-controlled gastrointestinal delivery systems, which include cationic and anionic drugs. Additional information regarding controlled release drug delivery systems may be found in Yie W. Chien, Novel Drug Delivery Systems, 1992 (Marcel Dekker, Inc.).

Dosages

A suitable dosage can be determined by an attending physician or other qualified medical personnel, based on various clinical factors. As is well known in the medical arts, dosages for any one patient depend upon many factors, including the patient's size, body surface area, age, the particular compound to be administered, sex of the patient, time, and route of administration, general health, and other drugs being administered concurrently. A subject antibody may be administered in amounts between 1 ng/kg body weight and 20 mg/kg body weight per dose, e.g. between 0.1 mg/kg body weight to 10 mg/kg body weight, e.g. between 0.5 mg/kg body weight to 5 mg/kg body weight; however, doses below or above this exemplary range are envisioned, especially considering the aforementioned factors. If the regimen is a continuous infusion, it can also be in the range of 1 μg to 10 mg per kilogram of body weight per minute.

Those of skill will readily appreciate that dose levels can vary as a function of the specific antibody, the severity of the symptoms and the susceptibility of the subject to side effects. Preferred dosages for a given compound are readily determinable by those of skill in the art by a variety of means.

Routes of Administration

A subject antibody is administered to an individual using any available method and route suitable for drug delivery, including in vivo and ex vivo methods, as well as systemic and localized routes of administration.

Conventional and pharmaceutically acceptable routes of administration include intranasal, intramuscular, intratracheal, subcutaneous, intradermal, topical application, intravenous, intraarterial, rectal, nasal, oral, and other enteral and parenteral routes of administration. Routes of administration may be combined, if desired, or adjusted depending upon the antibody and/or the desired effect. A subject antibody composition can be administered in a single dose or in multiple doses. In some embodiments, a subject antibody composition is administered orally. In some embodiments, a subject antibody composition is administered via an inhalational route. In some embodiments, a subject antibody composition is administered intranasally. In some embodiments, a subject antibody composition is administered locally. In some embodiments, a subject antibody composition is administered intracranially. In some embodiments, a subject antibody composition is administered intravenously.

The agent can be administered to a host using any available conventional methods and routes suitable for delivery of conventional drugs, including systemic or localized routes. In general, routes of administration contemplated by the invention include, but are not necessarily limited to, enteral, parenteral, or inhalational routes.

Parenteral routes of administration other than inhalation administration include, but are not necessarily limited to, topical, transdermal, subcutaneous, intramuscular, intraorbital, intracapsular, intraspinal, intrasternal, and intravenous routes, i.e., any route of administration other than through the alimentary canal. Parenteral administration can be carried to effect systemic or local delivery of a subject antibody. Where systemic delivery is desired, administration typically involves invasive or systemically absorbed topical or mucosal administration of pharmaceutical preparations.

A subject antibody can also be delivered to the subject by enteral administration. Enteral routes of administration include, but are not necessarily limited to, oral and rectal (e.g., using a suppository) delivery.

By treatment is meant at least an amelioration of the symptoms associated with the pathological condition afflicting the host, where amelioration is used in a broad sense to refer to at least a reduction in the magnitude of a parameter, e.g. symptom, associated with the pathological condition being treated, such as muscle atrophy. As such, treatment also includes situations where the pathological condition, or at least symptoms associated therewith, are completely inhibited, e.g. prevented from happening, or stopped, e.g. terminated, such that the host no longer suffers from the pathological condition, or at least the symptoms that characterize the pathological condition.

In some embodiments, a subject antibody is administered by injection and/or delivery, e.g., to a site in a brain artery or directly into brain tissue. A subject antibody can also be administered directly to a target site e.g., by biolistic delivery to the target site.

A variety of hosts (wherein the term “host” is used interchangeably herein with the terms “subject,” “individual,” and “patient”) are treatable according to the subject methods. Generally such hosts are “mammals” or “mammalian,” where these terms are used broadly to describe organisms which are within the class mammalia, including the orders carnivore (e.g., dogs and cats), rodentia (e.g., mice, guinea pigs, and rats), and primates (e.g., humans, chimpanzees, and monkeys). In some embodiments, the hosts will be humans.

Kits with unit doses of a subject antibody, e.g. in oral or injectable doses, are provided. In such kits, in addition to the containers containing the unit doses will be an informational package insert describing the use and attendant benefits of the antibody in treating pathological condition of interest. Preferred compounds and unit doses are those described herein above.

Treatment Methods

The present disclosure provides methods of treating an ACVR2A-associated condition, the methods generally involving administering to an individual in need thereof (e.g., an individual having a ACVR2A-associated condition) an effective amount of a subject antibody, alone (e.g., in monotherapy) or in combination (e.g., in combination therapy) with one or more additional therapeutic agents. In certain embodiments, an ACVR2A-specific antibody can be used for treating or preventing a disease or condition that can be treated by decreasing ACVR2A signaling. In certain embodiments, the present invention provides methods of treating or preventing a disease, disorder, or condition in an individual in need thereof through administering to the individual a therapeutically effective amount of an ACVR2A-specific antibody as described above. These methods are particularly aimed at therapeutic and prophylactic treatments of animals, and more particularly, humans.

Mice genetically deficient in the inhibin-α subunit are deficient in inhibin A and inhibin B, have gonadal tumors that overexpress activins A and B (Matzuk et al., 1992, Nature 360:313-319; Matzuk et al., 1994, Proc Natl Acad Sci USA 91:8817-8821). All such mice develop these tumors and eventually die of a cancer cachexia-like syndrome mediated by high levels of tumor-derived activin acting through ACVR2A (Coerver et al., 1996, Mol Endocrinol 10:534-543). While not wishing to limit the present invention, an antibody that specifically blocks binding of a ligand to ACVR2A may be useful for treating a variety of conditions that are related to muscle atrophy. For example, an ACVR2A-specific antibody may be used to reduce the effects of activin-producing tumors, alleviating activin-mediated cachexia, and prolonging patient survival. In some embodiments, the subject may have a muscle-wasting disorder such as insufficient lean body mass, a decrease in muscle mass or muscle function, cachexia or sarcopenia.

ACVR2A and ACVR2A-ligand complexes play essential roles in tissue growth as well as early developmental processes such as the correct formation of various structures or in one or more post-developmental capacities including sexual development, pituitary hormone production, and creation of bone and cartilage. Thus, ACVR2A-associated conditions include abnormal tissue growth and developmental defects. In addition, ACVR2A-associated conditions include, but are not limited to, disorders of cell growth and differentiation such as inflammation, allergy, autoimmune diseases, infectious diseases, and tumors.

Exemplary ACVR2A-associated conditions include neuromuscular disorders (e.g., muscular dystrophy and muscle atrophy), congestive obstructive pulmonary disease or pulmonary emphysema (and associated muscle wasting), muscle wasting syndrome, sarcopenia, cachexia, adipose tissue disorders (e.g., obesity), type 2 diabetes, and bone degenerative disease (e.g., osteoporosis). Other exemplary ACVR2A-associated conditions include musculodegenerative and neuromuscular disorders, tissue repair (e.g., wound healing), neurodegenerative diseases (e.g., amyotrophic lateral sclerosis), immunologic disorders (e.g., disorders related to abnormal proliferation or function of lymphocytes), and obesity or disorders related to abnormal proliferation of adipocytes.

In certain embodiments, an ACVR2A-specific antibody may be used as part of a treatment for a muscular dystrophy. The term “muscular dystrophy” refers to a group of degenerative muscle diseases characterized by gradual weakening and deterioration of skeletal muscles and sometimes the heart and respiratory muscles. Muscular dystrophies are genetic disorders characterized by progressive muscle wasting and weakness that begin with microscopic changes in the muscle. As muscles degenerate over time, the person's muscle strength declines. Exemplary muscular dystrophies that can be treated with a regimen including the subject ACVR2A-specific antibodies include: Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), Emery-Dreifuss muscular dystrophy (EDMD), limb-girdle muscular dystrophy (LGMD), fascioscapulohumeral muscular dystrophy (FSH or FSHD) (also known as Landouzy-Dejerine), myotonic muscular dystrophy (MMD) (also known as Steinert's Disease), oculopharyngeal muscular dystrophy (OPMD), distal muscular dystrophy (DD), congenital muscular dystrophy (CMD), and scapulohumeral muscular dystrophy (SMD).

Duchenne muscular dystrophy (DMD) was first described by the French neurologist Guillaume Benjamin Amand Duchenne in the 1860s. Becker muscular dystrophy (BMD) is named after the German doctor Peter Emil Becker, who first described this variant of DMD in the 1950s. DMD is one of the most frequent inherited diseases in males, affecting one in 3,500 boys. DMD occurs when the dystrophin gene, located on the short arm of the X chromosome, is broken. Since males only carry one copy of the X chromosome, they only have one copy of the dystrophin gene. Without the dystrophin protein, muscle is easily damaged during cycles of contraction and relaxation. While early in the disease muscle compensates by regeneration, later on muscle progenitor cells cannot keep up with the ongoing damage and healthy muscle is replaced by non-functional fibro-fatty tissue.

In other embodiments, ACVR2A-specific antibodies may also be used to treat or prevent muscular atrophy due to myopathies, examples of which include inflammatory myopathy, metabolic myopathy, and myotonia. Subject ACVR2A-specific antibodies have application in treating congenital myopathies such as myotubular myopathy, nemalene myopathy, and mitochondrial myopathy. The subject ACVR2A-specific antibodies may be used to treat inclusion body myositis, myoglobinurias, rhabdomyolysis, myositis ossificans, polymyositis, or dermatomyositis. In addition, ACVR2A-specific antibodies may treat or prevent muscle atrophy arising from glucocorticoid treatment, sarcopenia, prolonged bed rest, skeletal immobilization, sepsis, or congestive heart failure.

An ACVR2A-specific antibody may provide an effective means to increase muscle mass in other neuromuscular diseases or conditions that are in need of muscle growth. For example, amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease or motor neuron disease) is a chronic, incurable, and unstoppable CNS disorder that attacks the motor neurons, components of the CNS that connect the brain to the skeletal muscles. In ALS, the motor neurons deteriorate and eventually die, and though a person's brain normally remains fully functioning and alert, the command to move cannot reach the muscles, Most people who develop ALS are between 40 and 70 years old. The first motor neurons that weaken are those leading to the arms or legs. Those with ALS may have trouble walking, they may drop things, fall, slur their speech, and laugh or cry uncontrollably. Eventually the muscles in the limbs begin to atrophy from disuse. This muscle weakness will become debilitating and a person will need a wheel chair or become unable to function out of bed. Most ALS patients die from respiratory failure or from complications of ventilator assistance like pneumonia, 3-5 years from disease onset. Other neuromuscular diseases in which ACVR2A-specific antibodies may be useful include paralysis due to spinal cord injury or stroke; denervation due to trauma or degenerative, metabolic, or inflammatory neuropathy; adult motor neuron disease; autoimmune motor neuropathy with multifocal conductor block; and infantile or juvenile spinal muscular atrophy.

Increased muscle mass induced by ACVR2A-specific antibodies might also benefit those suffering from muscle wasting diseases. Gonzalez-Cadavid et al. (1998, Proc. Natl. Acad. Sci. USA 95:14938-43) reported that that GDF8 expression correlates inversely with fat-free mass in humans and that increased expression of the GDF8 gene is associated with weight loss in men with AIDS wasting syndrome. By inhibiting the function of GDF8 in AIDS patients, at least certain symptoms of AIDS may be alleviated, if not completely eliminated, thus significantly improving quality of life in AIDS patients.

The cancer anorexia-cachexia syndrome is among the most debilitating and life-threatening aspects of cancer. Progressive weight loss in cancer anorexia-cachexia syndrome is a common feature of many types of cancer and is responsible not only for a poor quality of life and poor response to chemotherapy, but also a shorter survival time than is found in patients with comparable tumors without weight loss. Associated with anorexia, fat and muscle tissue wasting, psychological distress, and a lower quality of life, cachexia arises from a complex interaction between the cancer and the host. It is one of the most common causes of death among cancer patients and is present in 80% at death. It is a complex example of metabolic chaos effecting protein, carbohydrate, and fat metabolism. Tumors produce both direct and indirect abnormalities, resulting in anorexia and weight loss. Currently, there is no treatment to control or reverse the process. Cancer anorexia-cachexia syndrome affects cytokine production, release of lipid-mobilizing and proteolysis-inducing factors, and alterations in intermediary metabolism. Although anorexia is common, a decreased food intake alone is unable to account for the changes in body composition seen in cancer patients, and increasing nutrient intake is unable to reverse the wasting syndrome. Cachexia is generally suspected in patients with cancer if an involuntary weight loss of greater than five percent of premorbid weight occurs within a six-month period.

Since systemic overexpression of GDF8 in adult mice was found to induce profound muscle and fat loss analogous to that seen in human cachexia syndromes (Zimmers et al., 2002, Science 296:1486-1488), the subject ACVR2A-specific antibodies can be, beneficially used to prevent, treat, or alleviate the symptoms of the cachexia syndrome, where muscle growth is desired. This would include cachexia associated with cancer as well as cachexia associated with rheumatoid arthritis.

Combination Therapy

In some embodiments, a subject treatment method involves administering a subject antibody and one or more additional therapeutic agents. Suitable additional therapeutic agents include, but are not limited to, anabolic steroids, deacetylase inhibitors and selective adrenergic receptor modulators (SARMs).

Subjects Suitable for Treatment

A variety of subjects are suitable for treatment with a subject method. Suitable subjects include any individual, e.g., a human, who has an ACVR2A-associated condition, who has been diagnosed with an ACVR2A-associated condition, who is at risk for developing an ACVR2A-associated condition, who has had an ACVR2A-associated condition and is at risk for recurrence of the an ACVR2A-associated condition, or who is recovering from an ACVR2A-associated condition.

EXAMPLES

The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the scope of what the inventors regard as their invention nor are they intended to represent that the experiments below are all or the only experiments performed. Efforts have been made to ensure accuracy with respect to numbers used (e.g. amounts, temperature, etc.) but some experimental errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, molecular weight is weight average molecular weight, temperature is in degrees Celsius, and pressure is at or near atmospheric. Standard abbreviations may be used, e.g., bp, base pair(s); kb, kilobase(s); pl, picoliter(s); s or sec, second(s); min, minute(s); h or hr, hour(s); aa, amino acid(s); kb, kilobase(s); bp, base pair(s); nt, nucleotide(s); i.m., intramuscular(ly); i.p., intraperitoneal(ly); s.c., subcutaneous(ly); and the like.

Example 1

Phage Display Screening

Phagemid expression of diversified monovalent Fab libraries was accomplished by standard methods. TG-1 cells transformed with expression plasmids were grown to mid log (O.D. 600.about.0.3) in 2-YT media supplemented with 100 mcg/ml ampicillin and 2% glucose repression and then infected with m13K07 helper phage and grown overnight in 2-YT media supplemented with 100 mcg ampicillin, 70 mcg/ml kanamycin, and 200 micromolar IPTG. Phage containing supernatants were precipitated using polyethylene glycol and PBS resuspended phage were used to pan on immobilized ACVR2.

Panning of the libraries was performed by using recombinant soluble extracellular domains of ACVR2 (Peprotech or R&D Systems) immobilized on the wells of a microtiter dish or biotinylated ACVR2 immobilized on streptavidin derivatized magnetic beads (Dynal-Life Technologies).

To identify phage clones that encoded ACVR2-binding monovalent Fabs, a portion of the eluted phage were used to infect E. coli HB2151 allowing expression of periplasmic phage-encoded monovalent Fabs. Individual clones were picked into deep-well plates and grown overnight in 2YT containing ampicillin and 0.2 mM IPTG. Bacteria were lysed in BPERII and the lysates were applied to ACVR2 coated plates. Following washing, binding of antibodies was detected using an HRP-conjugated anti-human kappa and lambda light chain antibody (Bethyl). Daughter plates were also inoculated and grown in 2YT-Amp-glucose for Sanger-based sequencing to determine the antibody heavy and light chain sequences.

Example 2

Initial ELISA Assays

The binding of ACVR2A-specific monoclonal antibodies to human ACVR2A, mouse ACVR2A, biotinylated goat anti-human kappa light chain (positive control) and human Fc (negative control) were determined by ELISA.

The results of this assay are shown in Table 4 below. The values shown are optical densities. The data in this table shows that the antibodies listed I specifically bind to ACVR2A. The sequences of the heavy and light chains of the antibodies listed in Table 4 are shown above in FIGS. 2A-2F.

TABLE 4
			Goat
			anti-
	Human	Mouse	Human	Human
Ab	ACVR2A	ACVR2A	Kappa	Fc
365_B04	1.993	2.179	3.121	0.271
365_B10	2.819	2.782	3.212	0.322
365_C03	2.257	2.648	3.499	0.332
365_C06	1.785	2.229	3.447	0.318
365_D04	2.269	2.389	3.517	0.316
365_E04	2.342	2.401	3.54	0.46
365_F11	2.01	2.141	3.502	0.302
365_G07	2.424	2.596	3.467	0.331
365_H08	2.674	2.607	3.589	0.488
366_A02	2.448	2.687	3.583	0.336
366_A04	1.823	1.988	3.397	0.319
366_D01	2.361	2.46	3.484	0.374
366_D03	2.233	2.375	3.475	0.318
366_F10	2.048	2.211	3.518	0.28
366_G06	2.676	2.818	3.407	0.341
367_B09	2.422	2.429	3.365	0.476
367_B11	2.34	2.463	3.598	0.37
367_C09	2.413	2.771	3.445	0.263
367_D11	2.395	2.54	3.39	0.304
367_F06	2.008	2.045	3.345	0.265
367_H01	2.817	2.695	3.654	0.388
368_A02	2.573	2.741	3.691	0.376
368_A06	2.249	2.515	3.282	0.483
368_A12	3.009	2.781	3.693	0.425
368_B03	2.045	2.045	3.377	0.297
368_B08	1.979	2.182	3.208	0.314
368_B10	2.349	2.417	3.024	0.412
368_B11	2.14	2.35	3.607	0.286
368_C09	2.478	2.611	3.461	0.341
368_D09	2.194	2.11	3.461	0.212
368_F02	2.184	2.272	3.653	0.317
368_F10	2.254	2.602	3.522	0.328
369_B03	3.321	3.314	3.521	0.62
369_G10	3.37	3.295	3.491	0.423
369_H03	2.829	3.085	3.469	0.498
370_B01	3.375	3.473	3.752	0.47
370_D06	2.257	2.658	3.483	0.334
370_G04	1.825	2.125	3.513	0.423
370_H08	2.937	3.24	3.647	0.538
371_A04	1.008	1.173	3.532	0.315
371_A09	1.855	1.998	3.617	0.302
371_D07	2.661	2.902	3.59	0.299
371_D12	1.89	1.999	3.435	0.337
371_H02	1.881	2.026	3.623	0.388
372_A09	2.433	2.56	3.498	0.31
372_B11	2.309	2.575	3.73	0.438
372_E02	2.841	2.743	3.581	0.431
373_E11	3.301	3.361	3.172	0.243
373_H02	3.245	3.257	3.239	0.287
374_B02	3.421	3.537	3.024	0.179
374_F03	3.532	3.617	3.233	0.185
375_A04	3.72	3.734	3.101	0.177
375_A11	3.729	3.696	3.047	0.176
375_C10	3.459	3.596	3.333	0.294
375_F12	2.951	3.143	3.17	0.175
375_H01	2.787	3.059	3.104	0.216
376_G02	3.694	3.696	3.546	0.285
365_A05	2.34	2.229	3.454	0.331
365_B08	1.137	1.257	3.037	0.229
365_B12	2.334	2.289	3.427	0.307
365_D03	2.351	2.484	3.526	0.346
365_D08	2.264	2.355	3.614	0.35
365_E06	1.988	2.063	3.295	0.301
365_F10	2.752	2.789	3.655	0.386
365_G06	2.198	2.021	3.343	0.32
365_G08	2.527	2.581	3.498	0.346
366_B09	2.304	2.532	3.386	0.283
366_C05	2.007	2.362	3.405	0.269
366_E07	1.677	1.856	3.144	0.262
366_G02	2.163	2.316	3.565	0.357
366_H01	2.794	2.775	3.715	0.384
367_C06	2.119	2.513	3.496	0.29
367_C12	2.065	2.103	3.576	0.31
367_E08	2.042	2.372	3.426	0.299
367_E10	2.765	2.975	3.481	0.271
367_F08	2.079	2.193	3.539	0.299
367_F10	2.215	2.357	3.425	0.253
367_G03	2.591	2.632	3.595	0.341
367_G11	2.559	2.672	3.557	0.305
367_H08	2.266	2.473	3.544	0.312
368_B04	2.266	2.729	3.292	0.304
368_B12	2.514	2.471	3.486	0.567
368_C04	2.485	2.474	3.67	0.302
368_C07	2.577	2.367	3.309	0.282
368_C12	2.488	2.446	3.617	0.346
368_D03	2.394	2.552	3.494	0.374
368_D06	2.027	2.109	3.407	0.265
368_D07	2.2	2.463	3.262	0.309
368_E05	1.868	2.067	3.369	0.266
368_E08	2.267	2.669	3.5	0.255
368_G11	2.105	2.368	3.502	0.306
368_H03	2.44	2.727	3.558	0.343
369_A04	2.761	2.858	3.505	0.353
369_A12	3.175	3.243	3.721	0.461
369_B07	2.631	2.898	3.386	0.319
369_B08	2.751	2.879	3.29	0.309
369_C06	2.755	3.065	3.175	0.414
369_C09	2.883	3.054	3.412	0.32
369_C11	2.799	2.912	3.484	0.378
369_E03	3.147	3.356	3.373	0.63
370_B06	2.876	3.092	3.371	0.441
370_B07	1.914	2.196	3.482	0.336
370_E12	3.388	3.435	3.658	0.656
370_H05	2.939	3.138	3.612	0.364
371_A05	3.047	3.24	3.605	0.369
371_B02	2	2.279	3.59	0.449
371_B11	3.182	3.261	3.594	0.549
371_C02	2.918	2.877	3.656	0.372
371_D05	2.718	3.112	3.438	0.339
371_F07	2.784	2.893	3.342	0.425
371_G07	2.8	2.988	3.413	0.548
372_D07	2.684	2.993	3.704	0.472
373_B01	3.258	3.584	3.114	0.197
373_D11	3.572	3.546	3.202	0.364
373_G06	3.397	3.525	3.231	0.196
374_A10	3.557	3.587	2.999	0.23
374_A12	3.312	3.256	3.063	0.308
374_B01	3.143	3.369	2.918	0.173
374_B07	3.713	3.705	3.295	0.25
374_H02	3.263	3.257	3.183	0.197
375_C03	3.001	3.243	3.162	0.217
375_C05	3.457	3.584	3.316	0.193
375_D02	3.629	3.558	3.202	0.191
375_G08	3.332	3.432	3.267	0.259
375_H04	3.106	3.159	3.148	0.181
376_D08	3.815	3.711	3.471	0.232
376_F09	3.501	3.588	3.353	0.25
376_H12	3.234	3.082	3.487	0.344
365_C05	2.564	2.808	3.527	0.271
365_E10	1.823	2.053	3.337	0.273
365_E12	3.321	3.276	3.522	0.338
365_F02	2.781	3.049	3.396	0.326
365_F03	2.631	2.99	3.574	0.347
365_G03	2.242	2.543	3.543	0.321
365_G04	2.096	2.48	3.295	0.295
365_G05	2.442	2.539	3.352	0.319
365_G09	2.617	2.933	3.671	0.288
365_H07	2.514	2.745	3.431	0.33
366_A06	1.97	2.254	3.24	0.334
366_A08	1.653	1.734	3.23	0.243
366_B05	2.385	2.461	2.955	0.24
366_B07	1.796	1.915	3.222	0.215
366_E01	2.693	2.717	3.66	0.397
366_E08	1.973	2.002	3.349	0.272
366_F02	2.149	2.108	3.597	0.371
366_G12	2.713	2.828	3.586	0.372
366_H04	2.69	2.829	3.524	0.359
367_A03	2.576	2.451	3.438	0.347
367_A06	2.339	2.566	3.358	0.378
367_A08	2.057	2.091	3.337	0.252
367_A10	1.892	2.163	3.392	0.315
367_A12	2.439	2.416	3.647	0.39
367_B01	2.839	2.907	3.674	0.408
367_B04	2.664	3.099	3.342	0.265
367_B12	3.015	3.028	3.745	0.414
367_C07	2.468	2.516	3.414	0.387
367_C10	2.529	2.61	3.386	0.233
367_D03	2.594	2.451	3.455	0.29
367_D06	2.045	2.353	3.25	0.283
367_D08	2.183	2.373	3.501	0.237
367_D12	2.435	2.689	3.569	0.309
367_E05	2.353	2.639	3.466	0.333
367_F01	2.425	2.757	3.724	0.33
367_G01	1.8	1.944	3.578	0.356
367_G04	2.978	3.042	3.356	0.287
367_H02	1.077	1.199	3.616	0.378
367_H03	2.041	2.2	3.341	0.377
368_A03	2.834	2.833	3.411	0.348
368_A04	2.349	2.352	3.565	0.283
368_B09	2.543	2.808	3.434	0.258
368_C02	1.377	1.488	3.513	0.321
368_C08	2.259	2.432	3.383	0.289
368_E12	1.286	1.554	3.652	0.347
368_F09	2.389	2.449	3.578	0.242
368_H02	2.406	2.544	3.578	0.348
368_H05	1.954	2.197	3.342	0.277
369_A07	3.548	3.564	3.421	0.288
369_B05	2.777	3.057	3.44	0.314
369_C05	2.545	2.718	3.022	0.32
369_D03	3.277	3.554	3.606	0.391
369_D07	3.069	2.914	3.259	0.363
369_D09	3.303	3.051	3.446	0.287
369_E06	3.134	3.109	3.515	0.306
369_F08	0.503	0.589	3.099	0.302
369_G08	3.297	3.492	3.582	0.312
370_A02	2.901	2.907	3.624	0.425
370_B03	3.714	3.567	3.607	0.3
370_B11	2.076	2.449	3.685	0.326
370_B12	2.925	3.077	3.563	0.478
370_D01	3.137	3.17	3.664	0.382
370_D05	2.976	3.125	3.49	0.333
370_F03	1.136	1.25	3.301	0.373
370_H02	3.301	3.39	3.667	0.386
370_H07	3	3.245	3.511	0.403
371_A10	2.812	2.779	3.477	0.338
371_B03	1.634	1.935	3.482	0.367
371_B04	2.465	3.129	2.269	0.295
371_B09	0.825	0.827	2.702	0.292
371_B12	2.555	2.4	3.483	0.378
371_C01	2.001	2.273	3.594	0.402
371_C04	2.049	2.246	3.453	0.314
371_C05	1.24	1.355	3.079	0.269
371_C12	3.099	3.196	3.683	0.544
371_D02	2.939	2.991	3.578	0.385
371_D04	1.023	1.295	3.3	0.276
371_E06	3.003	3.029	3.443	0.33
371_E07	3.091	3.348	3.437	0.337
371_E10	3.062	3.052	3.486	0.341
371_F10	2.339	2.31	3.529	0.299
371_F11	3.039	3.253	3.676	0.331
371_G02	3.118	3.06	3.673	0.514
371_G04	3.625	3.577	3.544	0.325
371_G09	2.745	3.066	3.577	0.315
371_G11	2.84	2.752	3.666	0.399
371_H04	3.258	3.507	3.576	0.35
371_H05	1.202	1.245	3.271	0.321
371_H06	3.027	3.111	3.698	0.346
371_H08	1.662	2.039	3.472	0.309
371_H10	2.189	2.553	3.548	0.358
372_B02	3.172	3.509	3.665	0.371
372_C06	3.206	3.536	3.491	0.489
372_D03	3.042	3.289	3.603	0.319
372_E01	3.341	3.34	3.598	0.409
372_G12	2.409	2.725	3.495	0.439
373_A01	3.177	3.477	2.952	0.177
373_A03	3.647	3.634	3.079	0.189
373_A05	3.45	3.423	3.033	0.172
373_A09	3.66	3.615	3.107	0.248
373_A11	3.763	3.679	3.086	0.184
373_A12	3.59	3.315	3.093	0.179
373_B05	3.586	3.526	3.233	0.184
373_B07	3.661	3.61	3.304	0.208
373_C03	3.69	3.654	3.304	0.171
373_C07	3.569	3.578	3.298	0.206
373_C10	3.653	3.645	3.235	0.318
373_D03	3.745	3.694	3.18	0.18
373_D12	3.398	3.207	3.212	0.224
373_E10	3.722	3.636	3.2	0.188
373_F08	3.76	3.701	3.215	0.202
373_F11	3.354	3.46	3.319	0.204
373_F12	3.245	3.217	3.063	0.158
373_G08	3.651	3.673	3.284	0.172
373_H03	3.268	3.289	3.221	0.172
373_H07	3.253	3.27	3.233	0.199
373_H09	0.93	1.354	3.084	0.166
374_A06	3.775	3.747	2.999	0.173
374_A09	3.583	3.644	2.971	0.231
374_B03	3.687	3.697	3.066	0.166
374_B05	3.681	3.652	3.164	0.168
374_B08	3.6	3.629	3.124	0.188
374_B10	3.711	3.686	3.004	0.17
374_C01	2.685	2.929	3.078	0.167
374_C09	3.431	3.509	3.14	0.154
374_C12	3.667	3.326	3.145	0.308
374_D03	3.3	3.48	3.025	0.216
374_D05	3.434	3.565	3.148	0.171
374_D06	3.776	3.674	3.123	0.172
374_D07	3.71	3.684	3.26	0.176
374_D10	3.562	3.638	3.273	0.329
374_E10	3.736	3.768	3.375	0.165
374_E12	3.613	3.284	3.293	0.177
374_F06	3.723	3.704	3.179	0.201
374_F07	3.467	3.542	3.209	0.176
374_F08	3.671	3.676	3.176	0.211
374_G03	3.791	3.64	3.219	0.193
374_G08	3.706	3.704	3.211	0.206
374_G09	3.656	3.598	3.258	0.223
374_G10	3.681	3.737	3.233	0.173
374_G11	3.651	3.597	3.245	0.179
374_H01	3.084	3.261	3.068	0.251
374_H11	3.275	3.285	3.15	0.169
375_A01	3.281	3.676	2.908	0.196
375_A07	3.575	3.644	3.11	0.188
375_A08	3.676	3.687	3.14	0.205
375_A12	3.657	3.347	3.137	0.174
375_B12	3.654	3.338	3.28	0.223
375_C04	3.677	3.675	3.207	0.221
375_D01	3.298	3.608	3.1	0.182
375_D10	3.258	3.454	3.207	0.228
375_E02	3.582	3.691	3.199	0.496
375_E03	3.568	3.638	3.184	0.181
375_E05	3.669	3.709	3.283	0.296
375_E06	3.846	3.672	3.328	0.188
375_E10	3.689	3.792	3.293	0.187
375_F02	3.605	3.646	3.203	0.205
375_F07	3.675	3.707	3.216	0.172
375_F08	3.502	3.581	3.315	0.201
375_G04	2.909	3.294	3.193	0.161
375_G05	3.712	3.745	3.264	0.21
375_H05	3.355	3.331	3.171	0.167
375_H07	3.304	3.293	3.273	0.346
376_A03	3.613	3.65	3.231	0.328
376_B03	3.678	3.668	3.519	0.253
376_B10	3.595	3.665	3.457	0.232
376_C04	3.63	3.654	3.397	0.219
376_C08	3.612	3.627	3.462	0.246
376_D07	3.381	3.444	3.436	0.318
376_E02	3.298	3.376	3.408	0.222
376_E11	3.682	3.646	3.471	0.268
376_F01	2.769	3.015	3.177	0.199
376_F06	3.525	3.649	3.469	0.284
376_G05	3.745	3.773	3.489	0.252
376_G06	3.424	3.58	3.489	0.267
376_G10	3.545	3.524	3.542	0.321
376_H01	3.113	3.308	3.277	0.607
376_H04	3.309	3.338	3.513	0.34
376_H11	3.293	3.309	3.433	0.325
365_A08	1.584	1.593	3.2	0.256
365_A09	2.449	2.479	3.302	0.339
365_C02	2.155	2.332	3.447	0.362
365_C04	2.262	2.673	3.551	0.305
365_D02	2.539	2.699	3.518	0.486
365_D07	1.831	2.058	3.382	0.302
365_D10	2.393	2.236	3.272	0.641
365_E11	1.741	1.736	3.568	0.301
365_F05	2.141	2.232	3.416	0.376
365_H05	2.102	2.195	3.46	0.361
366_D08	2.166	2.463	3.65	0.312
366_F08	1.862	2.004	3.468	0.316
366_G09	1.855	2.041	3.435	0.291
367_A02	2.231	2.416	3.581	0.305
367_B06	1.817	1.889	3.019	0.378
367_C08	1.119	1.218	3.054	0.278
367_D05	1.26	1.373	3.341	0.265
367_D09	2.147	2.045	3.372	0.381
367_E07	1.935	2.055	3.215	0.221
367_E12	2.695	2.913	3.706	0.453
367_F09	1.795	1.818	3.455	0.289
367_H05	2.439	2.698	3.59	0.51
367_H10	2.577	2.353	3.55	0.326
368_B02	2.075	2.24	3.606	0.337
368_C11	2.027	2.209	3.558	0.275
368_D02	1.925	2.26	3.522	0.321
368_D12	2.254	2.283	3.568	0.329
368_F06	1.599	1.68	3.315	0.249
368_G03	2.726	2.746	3.392	0.312
368_G10	2.064	2.283	3.454	0.356
368_H06	2.351	2.654	3.612	0.311
368_H11	1.954	2.129	3.511	0.355
369_A11	2.643	2.774	3.286	0.366
369_C12	3.43	3.447	3.742	0.418
369_D08	2.942	3.127	3.063	0.241
369_E05	1.405	1.642	1.904	0.282
369_E08	1.028	1.227	1.116	0.272
369_F05	0.796	0.931	3.46	0.331
369_F09	3.227	3.381	3.601	0.5
369_G05	3.036	3.278	3.309	0.384
369_H02	3.088	3.29	3.572	0.408
369_H08	3.159	3.231	3.556	0.389
369_H12	3.463	3.42	3.652	0.414
370_B08	3.131	3.247	3.353	0.302
370_C06	3.141	3.414	3.55	0.303
370_C07	3.351	3.369	3.299	0.316
370_C10	1.3	1.383	3.352	0.332
370_D03	3.135	3.249	3.582	0.57
370_D09	2.924	2.531	3.484	0.287
370_E04	2.572	2.721	3.398	0.292
370_E05	2.585	2.768	3.519	0.427
370_F01	3.004	3.136	3.669	0.407
370_F02	2.682	2.891	3.627	0.376
370_F12	3.551	3.572	3.644	0.457
370_G08	3.212	3.326	3.564	0.364
370_H04	3.484	3.558	3.615	0.596
370_H06	3.22	3.394	3.514	0.358
371_B01	3.26	3.271	3.584	0.464
371_C06	2.486	3.012	3.435	0.308
371_C07	1.391	1.446	3.359	0.287
371_E05	2.989	3.178	3.446	0.59
371_E08	2.114	2.267	2.64	0.251
371_E09	2.078	2.283	3.155	0.306
371_E12	3.09	2.993	3.622	0.398
371_F03	1.19	1.302	1.819	0.252
371_F09	3.369	3.57	3.597	0.602
371_G01	2.014	2.242	1.786	0.375
371_H11	2.89	3.121	3.597	0.363
372_B09	3.108	3.011	3.502	0.308
372_E08	2.559	2.816	3.507	0.369
372_F02	3.006	3.094	3.695	0.411
372_H11	2.616	2.86	3.645	0.392
373_A06	3.636	3.624	3.073	0.193
373_B09	3.6	3.621	3.242	0.172
373_D06	3.633	3.574	3.208	0.192
373_F07	3.613	3.62	3.129	0.172
373_G02	3.59	3.559	3.223	0.226
374_A04	3.654	3.682	2.99	0.275
374_A05	3.604	3.6	2.923	0.159
374_C10	3.567	3.671	3.08	0.174
374_D04	3.629	3.649	3.053	0.179
374_D09	3.609	3.646	3.096	0.171
374_G05	3.658	3.667	3.003	0.158
374_H05	3.315	3.297	3.042	0.257
375_A03	3.615	3.619	3.087	0.203
375_B03	3.678	3.7	3.241	0.209
375_C01	2.962	3.27	3.136	0.191
375_C11	3.589	3.613	3.263	0.199
375_F10	3.691	3.767	3.295	0.21
375_H08	3.308	3.28	3.324	0.204
376_A02	3.716	3.634	3.194	0.22
376_A05	3.648	3.644	3.184	0.256
376_A07	3.7	3.722	3.193	0.221
365_A03	3.4	3.243	3.443	0.342
365_A11	2.039	1.937	3.267	0.299
365_A12	2.674	2.871	3.668	0.422
365_B01	2.386	2.646	3.491	0.445
365_B06	2.246	2.418	3.277	0.281
365_B07	2.112	2.213	3.229	0.269
365_B11	2.844	2.755	3.581	0.305
365_C01	2.869	3.025	3.626	0.376
365_C10	2.451	2.441	3.413	0.397
365_C11	2.656	2.781	3.668	0.296
365_C12	1.924	2.04	3.576	0.332
365_D09	1.523	1.35	3.375	0.302
365_D11	2.342	2.224	3.382	0.299
365_D12	2.567	2.613	3.53	0.34
365_E01	2.906	2.837	3.542	0.363
365_E05	2.181	2.437	3.36	0.379
365_E07	2.383	2.701	3.513	0.302
365_E09	1.906	2.16	3.474	0.322
365_F01	2.51	2.471	3.509	0.341
365_F06	1.953	2.082	3.397	0.329
365_F12	2.913	2.828	3.633	0.411
365_G01	2.483	2.647	3.447	0.39
365_G11	1.745	1.785	3.473	0.278
365_H02	2.732	2.908	3.58	0.407
365_H03	2.322	2.654	3.269	0.366
365_H06	2.244	2.459	3.437	0.367
365_H10	2.677	2.823	3.513	0.349
365_H11	3.239	3.353	3.614	0.375
365_H12	2.968	2.908	3.778	0.451
366_A07	2.417	2.679	3.365	0.309
366_B08	2.148	2.376	3.054	0.403
366_B10	2.328	2.444	3.059	0.424
366_B12	3.244	2.989	3.444	0.311
366_D04	2.079	2.125	3.463	0.338
366_E10	2.354	2.389	3.454	0.271
366_F04	1.726	1.912	3.366	0.281
366_F05	2.191	2.668	3.245	0.279
366_F07	2.386	2.534	3.473	0.353
366_G04	1.851	2.176	3.286	0.31
366_G05	2.212	2.496	3.262	0.28
366_H06	2.289	2.591	3.386	0.285
366_H07	2.526	2.673	3.605	0.285
366_H08	2.593	2.77	3.551	0.417
366_H09	2.095	2.437	3.423	0.328
367_A04	2.142	2.202	3.303	0.267
367_A05	2.218	2.384	3.381	0.269
367_B02	2.288	2.422	3.533	0.302
367_B03	2.479	2.659	3.445	0.318
367_B07	1.419	1.488	3.337	0.236
367_B08	2.128	2.245	3.033	0.37
367_C01	2.617	2.987	3.71	0.348
367_C05	2.215	2.856	3.424	0.255
367_C11	2.329	2.545	3.449	0.45
367_D10	2.699	2.667	3.38	0.251
367_E01	2.546	2.523	3.607	0.351
367_E04	2.406	2.573	3.501	0.284
367_E06	2.022	2.313	3.477	0.271
367_E09	1.664	1.81	3.329	0.249
367_E11	2.395	2.909	3.607	0.244
367_F03	2.1	2.392	3.446	0.301
367_F07	2.126	2.246	3.261	0.242
367_F11	1.714	1.873	3.477	0.267
367_G05	2.41	2.711	3.371	0.283
367_G06	2.641	2.81	3.348	0.28
367_G10	2.115	2.316	3.448	0.286
367_H06	2.695	3.083	3.651	0.313
367_H11	2.371	2.693	3.609	0.323
368_A01	2.994	2.9	3.683	0.396
368_A05	2.708	2.696	3.459	0.285
368_A07	2.11	2.312	3.65	0.261
368_A09	2.51	2.628	3.549	0.277
368_B01	2.607	2.588	3.705	0.365
368_B06	2.059	2.341	3.157	0.393
368_B07	1.909	2.065	3.135	0.344
368_C05	1.818	2.018	3.359	0.246
368_D01	2.751	2.971	3.647	0.319
368_D04	2.461	2.699	3.666	0.338
368_D05	2.857	2.868	3.385	0.282
368_D11	2.796	2.96	3.487	0.297
368_E01	2.566	2.849	3.736	0.392
368_E02	2.5	2.788	3.679	0.424
368_E04	3.08	3.232	3.476	0.32
368_E06	2.328	2.339	3.505	0.325
368_E07	1.067	1.169	3.453	0.251
368_F03	2.352	2.601	3.604	0.323
368_F11	2.578	2.726	3.526	0.338
368_G01	2.646	2.824	3.622	0.431
368_G12	2.457	2.535	3.518	0.341
368_H04	1.063	1.362	3.513	0.319
369_A02	3.147	3.457	3.493	0.383
369_A03	0.451	0.561	3.169	0.347
369_B01	3.358	3.457	3.588	0.487
369_C02	3.6	3.517	3.543	0.369
369_C03	3.371	3.649	3.516	0.323
369_C04	1.639	1.649	2.459	0.248
369_D01	3.127	3.317	3.63	0.595
369_D02	3.287	3.436	3.527	0.407
369_D04	3.054	2.968	3.589	0.435
369_D12	3.041	3.105	3.533	0.425
369_E02	2.144	2.341	3.429	0.365
369_E11	2.889	3.202	3.694	0.343
369_E12	2.464	2.692	3.667	0.452
369_F01	3.278	3.418	3.469	0.554
369_F02	3.071	3.35	3.556	0.478
369_F03	2.575	2.749	3.438	0.389
369_F06	3.109	3.066	3.51	0.353
369_F10	3.048	3.225	3.667	0.361
369_F11	3.196	3.373	3.657	0.37
369_G01	3.567	3.666	3.439	0.403
369_G04	2.365	2.685	3.316	0.385
369_G06	2.98	2.914	3.378	0.474
369_G11	3.028	3.06	2.594	0.331
369_G12	1.768	1.882	2.652	0.353
369_H05	3.249	3.342	3.54	0.457
369_H06	3.235	3.555	3.5	0.347
369_H09	2.364	2.643	3.507	0.365
370_A01	2.859	2.955	3.622	0.637
370_A03	3.544	3.633	3.564	0.424
370_A04	2.566	2.736	3.476	0.377
370_A12	3.062	3.188	3.719	0.674
370_C01	3.285	3.38	3.615	0.403
370_C03	3.592	3.773	3.571	0.35
370_C05	3.208	3.546	3.557	0.346
370_C08	2.73	2.967	3.111	0.381
370_C09	1.974	2.248	3.483	0.292
370_D04	3.59	3.737	3.6	0.371
370_D11	2.721	2.794	3.381	0.34
370_E03	3.636	3.738	3.57	0.361
370_E06	2.903	3.025	3.608	0.375
370_E09	3.45	3.555	3.597	0.338
370_F05	2.758	2.913	3.536	0.406
370_F07	3.451	3.534	3.515	0.384
370_F10	3.145	3.216	3.636	0.441
370_G02	2.982	3.22	3.625	0.388
370_G03	3.103	3.435	3.579	0.421
370_G06	2.191	2.334	3.408	0.356
370_G09	3.006	3.136	3.641	0.393
370_G10	2.985	2.744	3.49	0.315
370_G11	2.975	3.07	3.72	0.529
370_H01	3.31	3.179	3.651	0.436
370_H09	2.948	3.277	3.542	0.348
371_A03	2.843	2.622	3.563	0.354
371_A06	2.65	2.786	3.51	0.337
371_A07	2.875	3.059	3.651	0.336
371_A08	1.061	1.161	2.442	0.304
371_A12	3.168	3.299	3.631	0.483
371_B06	2.692	2.712	3.296	0.356
371_B07	2.779	3.045	3.329	0.308
371_C03	3.013	3.241	3.598	0.311
371_D06	1.477	1.555	3.322	0.295
371_D09	2.889	2.936	2.168	0.268
371_F01	2.41	2.618	3.678	0.41
371_F04	2.946	3.102	3.66	0.345
371_F06	2.414	2.795	3.456	0.289
371_F08	2.196	2.546	3.427	0.301
371_G05	1.249	1.329	3.082	0.313
371_G10	1.646	1.922	3.406	0.439
371_H09	2.962	3.225	3.656	0.32
372_A04	3.204	3.404	3.643	0.339
372_B04	2.611	3.122	3.59	0.333
372_C07	2.409	2.638	3.462	0.279
372_D02	2.657	2.907	3.579	0.433
372_F03	3.192	3.308	3.595	0.438
372_F06	2.259	2.539	3.483	0.38
372_F08	3.382	3.217	3.445	0.335
372_F09	3.166	3.043	3.474	0.268
373_A02	2.803	2.974	2.955	0.159
373_A08	3.301	3.309	3.112	0.195
373_A10	3.544	3.55	3.096	0.175
373_B04	3.605	3.617	3.255	0.176
373_B06	3.441	3.43	3.236	0.221
373_B10	3.655	3.597	3.15	0.174
373_B12	3.122	3.075	3.27	0.172
373_C02	3.452	3.466	3.146	0.17
373_C04	3.356	3.502	3.196	0.157
373_C06	3.545	3.531	3.163	0.163
373_C08	3.048	3.193	3.189	0.16
373_C11	3.49	3.468	3.168	0.171
373_D01	3.235	3.574	3.041	0.174
373_D04	3.678	3.646	3.154	0.168
373_D05	3.683	3.734	3.253	0.179
373_D08	3.656	3.665	3.241	0.182
373_D10	3.61	3.61	3.114	0.189
373_E01	2.347	2.56	2.986	0.16
373_E05	3.545	3.592	3.24	0.176
373_E07	3.483	3.536	3.231	0.294
373_E12	3.627	3.333	3.116	0.17
373_G10	3.538	3.563	3.261	0.2
373_G12	3.472	3.288	3.259	0.174
373_H01	3.104	3.28	3.123	0.198
373_H05	3.286	3.295	3.216	0.201
374_A07	3.624	3.712	3.072	0.206
374_B04	3.67	3.641	3.3	0.222
374_B06	3.482	3.595	3.084	0.157
374_B12	3.489	3.326	3.054	0.257
374_C03	3.583	3.612	3.056	0.208
374_C06	3.715	3.712	3.236	0.18
374_D01	3.244	3.578	2.935	0.198
374_D08	3.503	3.591	3.017	0.201
374_E01	3.238	3.556	3.037	0.235
374_E02	3.235	3.329	3.176	0.527
374_E05	3.561	3.568	3.176	0.244
374_E07	3.632	3.581	3.203	0.3
374_E08	3.496	3.524	3.263	0.251
374_E11	3.607	3.586	3.343	0.186
374_F01	3.291	3.597	3.026	0.165
374_F02	3.565	3.586	3.157	0.169
374_F04	3.576	3.645	3.228	0.163
374_F10	3.211	3.453	3.283	0.524
374_F11	3.657	3.608	3.151	0.191
374_G04	2.096	2.317	3.025	0.161
374_G06	3.256	3.421	3.289	0.25
374_G07	3.631	3.723	3.257	0.214
374_H03	3.265	3.268	3.065	0.162
374_H04	3.277	3.31	3.189	0.167
374_H06	3.297	3.264	3.081	0.166
374_H07	3.241	3.251	2.973	0.163
374_H09	3.249	3.264	3.039	0.158
375_A05	3.721	3.685	3.12	0.202
375_C06	2.646	3.212	3.289	0.2
375_D04	3.691	3.699	3.166	0.182
375_D05	3.465	3.609	3.215	0.202
375_D07	3.563	3.633	3.253	0.176
375_D08	3.287	3.403	3.302	0.234
375_D12	3.24	3.156	3.23	0.193
375_E01	3.159	3.627	3.111	0.164
375_E07	3.683	3.81	3.06	0.158
375_H12	3.256	3.104	3.263	0.188
376_A04	3.587	3.578	3.123	0.245
376_A10	3.676	3.642	3.174	0.279
376_A12	3.696	3.341	3.217	0.22
376_B04	3.409	3.479	3.577	0.293
376_B05	3.646	3.778	3.519	0.242
376_B09	3.777	3.717	3.506	0.227
376_B11	3.69	3.753	3.608	0.261
376_C01	3.264	3.599	3.198	0.324
376_C02	3.445	3.529	3.443	0.222
376_C12	3.698	3.322	3.391	0.438
376_D05	3.599	3.707	3.337	0.215
376_D11	3.698	3.621	3.433	0.267
376_E03	3.788	3.744	3.425	0.234
376_E08	3.64	3.638	3.473	0.332
376_F03	3.289	3.471	3.443	0.261
376_F04	3.066	3.29	3.415	0.222
376_G08	3.695	3.637	3.473	0.22
376_G09	3.678	3.646	3.446	0.23
376_H09	3.318	3.299	3.455	0.281
376_H10	3.28	3.293	3.538	0.318
365_E02	2.446	2.609	3.503	0.357
370_G12	1.337	1.6	3.523	0.418
368_C01	2.607	2.922	3.714	0.41
376_C06	3.487	3.563	3.43	0.29
368_D10	2.245	2.449	3.258	0.245
365_G12	2.742	2.748	3.548	0.556
367_C03	2.301	2.808	3.513	0.275
367_H07	2.719	2.684	3.463	0.297
371_D03	1.54	1.826	3.57	0.333
369_C10	2.48	2.456	3.373	0.32
367_F05	2.269	2.485	3.44	0.386
365_C07	1.943	1.917	3.171	0.311
374_C08	3.295	3.417	3.178	0.178
376_A06	3.694	3.742	3.162	0.262
376_B07	3.732	3.714	3.526	0.234
365_F07	3.122	3.184	3.393	0.331
369_E10	3.36	3.534	3.594	0.412
373_E03	3.465	3.465	3.247	0.194
366_B04	2.805	3.046	3.397	0.331
376_F12	3.131	3.247	3.441	0.323
369_F07	3.431	3.43	3.47	0.335
368_C06	0.738	1.034	3.524	0.255
376_E12	3.61	3.316	3.416	0.306
371_H01	3.027	2.995	3.693	0.471
367_E02	1.871	2.026	3.438	0.37
365_F04	2.26	2.509	3.471	0.403
370_A09	3.461	3.269	3.576	0.361
365_B03	2.645	2.53	3.377	0.444
369_A05	3.285	3.25	3.48	0.588
373_H10	3.243	3.251	3.189	0.2
367_A09	2.178	2.41	3.454	0.259
370_F08	2.339	2.994	3.587	0.495
376_B01	3.278	3.67	3.242	0.308
365_D05	2.578	2.72	3.514	0.357
373_E04	3.556	3.546	3.301	0.251
368_G05	2.175	2.421	3.354	0.245
365_A01	2.765	2.9	3.508	0.528
373_H06	3.004	3.151	3.3	0.2
369_G07	3.322	3.369	2.976	0.32
373_G05	3.612	3.615	3.224	0.273
372_F07	3.248	3.241	3.401	0.296
370_H03	3.426	3.565	3.558	0.381
366_A03	1.152	1.119	3.314	0.303
365_A07	2.244	2.255	3.407	0.284
376_B06	3.697	3.773	3.457	0.222
374_C11	3.641	3.593	3.215	0.471
375_A06	3.653	3.707	3.114	0.298
365_B09	3.264	3.319	3.282	0.272
373_E06	3.706	3.639	3.221	0.187
374_C05	3.698	3.693	3.176	0.175
376_C11	3.704	3.626	3.46	0.23
373_C09	3.64	3.597	3.22	0.17
368_H01	3.027	3.142	3.693	0.374
373_B03	3.638	3.621	3.161	0.18
374_C04	3.741	3.741	3.166	0.201
371_F05	2.89	3.149	3.33	0.297
369_A10	3.375	3.139	3.414	0.348
366_A05	2.624	2.596	3.477	0.284
375_G07	3.633	3.672	3.197	0.178
374_D02	3.06	3.2	2.994	0.204
365_A10	2.185	2.492	3.451	0.293
375_A02	2.977	3.178	3.066	0.186
371_G03	3.121	3.267	3.593	0.359
370_E07	3.442	3.496	3.453	0.379
375_B04	3.693	3.73	3.259	0.19
367_G07	3.019	3.197	3.287	0.295
366_C02	3.033	3.04	3.43	0.341
375_C12	3.662	3.328	3.266	0.197
365_F08	2.246	2.611	3.626	0.437
368_G09	2.438	2.815	3.62	0.281
368_E11	2.573	2.923	3.73	0.341
367_F02	2.375	2.268	3.522	0.315
373_B08	3.698	3.663	3.218	0.17
374_A11	3.645	3.722	2.806	0.15
373_B11	3.719	3.652	3.217	0.178
373_F03	3.652	3.603	3.213	0.179
372_D04	3.401	3.408	3.384	0.419
366_C01	2.307	2.406	3.601	0.382
367_A01	3.182	3.284	3.51	0.391
366_H05	2.445	2.737	3.47	0.418
369_B09	1.624	1.577	2.216	0.253
366_D07	2.413	2.623	3.383	0.418
369_D11	2.988	2.99	3.454	0.35
370_B05	2.839	3.111	3.492	0.593
366_D02	2.274	2.549	3.567	0.349
368_H12	2.636	2.693	3.572	0.381
368_F12	1.689	1.702	3.515	0.349
370_A06	2.594	2.769	3.471	0.331
369_F12	2.732	2.819	3.596	0.434
366_A09	1.787	1.926	3.277	0.266
368_H07	2.707	2.864	3.553	0.421
370_C04	2.319	2.632	3.6	0.334
373_E02	3.612	3.643	2.921	0.158
374_E09	3.671	3.578	3.157	0.162
371_C09	3.369	3.289	3.393	0.308
369_B12	2.666	2.759	3.562	0.4
369_B02	3.4	3.546	3.522	0.456
365_C09	2.052	2.178	3.272	0.266
374_B09	3.621	3.652	3.194	0.172
374_D12	3.55	3.28	3.087	0.235
374_C02	3.676	3.64	3.059	0.167
374_H08	3.307	3.271	3.089	0.199
369_D06	3.438	3.346	3.11	0.324
366_B06	2.474	2.453	3.104	0.415
367_A11	2.344	2.521	3.611	0.3
369_F04	1.949	2.171	3.459	0.369
369_A01	3.6	3.66	3.546	0.456
373_H12	3.061	2.985	3.004	0.162
376_C07	3.697	3.714	3.419	0.265
366_E02	2.257	2.581	3.456	0.37
376_G01	3.341	3.663	3.18	0.227
373_F02	3.623	3.6	3.149	0.175
376_E09	3.741	3.76	3.483	0.246
365_H04	2.471	2.588	3.495	0.371
369_E04	2.883	3.304	3.516	0.387
374_B11	3.692	3.657	3.175	0.17
376_G11	3.646	3.604	3.538	0.285
374_E04	3.74	3.716	3.187	0.169
373_E08	2.966	3.235	3.199	0.165
375_B10	3.651	3.74	3.138	0.17
365_E08	2.591	2.585	3.331	0.298
374_G02	3.515	3.538	3.174	0.175
373_D09	3.463	3.505	3.043	0.16
365_A04	1.487	1.405	3.28	0.25
371_B05	1.051	1.243	1.653	0.246
376_H08	3.305	3.279	3.527	0.274
367_G08	2.686	2.779	3.319	0.33
372_H03	2.322	2.697	3.642	0.437
366_E03	2.551	2.724	3.536	0.384
371_F12	2.474	2.304	3.616	0.413
366_C03	2.414	2.736	3.549	0.274
376_A01	3.243	3.661	2.985	0.239
365_E03	2.559	2.692	3.332	0.314
371_B10	3.313	3.36	3.441	0.387
369_G09	3.36	3.269	3.605	0.395
369_A06	2.891	3.012	3.32	0.394
369_C08	2.32	2.325	2.797	0.241
373_A07	3.525	3.594	3.114	0.177
367_D02	2.464	2.464	3.462	0.321
374_C07	3.651	3.698	3.22	0.225
374_A03	3.58	3.71	3.05	0.178
365_A02	3.028	2.962	3.492	0.374
365_D06	2.953	3.075	3.421	0.319
366_C07	3.016	3.06	3.368	0.301
367_F12	2.38	2.285	3.599	0.355
369_E09	3.627	3.767	3.483	0.278
365_G02	1.984	2.155	3.447	0.325
373_D02	3.729	3.645	3.187	0.18
374_E03	3.716	3.789	3.127	0.176
374_D11	3.639	3.579	2.905	0.162
370_D07	2.806	3.141	3.384	0.309
374_A08	3.589	3.673	2.944	0.16
374_G01	3.344	3.595	2.922	0.161
374_G12	3.195	3.215	3.149	0.214
375_G10	3.481	3.639	3.302	0.175
369_H11	1.445	1.639	2.21	0.382
375_G12	3.356	3.29	3.304	0.199
366_F06	1.874	2.155	3.445	0.394
368_G07	1.788	2.048	3.164	0.29
367_H04	1.623	1.849	3.395	0.289
374_E06	3.844	3.755	3.245	0.191
370_A10	2.581	2.878	3.467	0.434
368_H10	2.281	2.156	3.359	0.281
368_G08	1.603	1.752	3.291	0.329
365_H09	2.384	2.563	3.53	0.365
370_A08	2.406	2.335	3.522	0.319
368_B05	1.732	1.755	3.257	0.281
375_F01	3.16	3.455	2.956	0.166
374_F09	3.533	3.617	3.142	0.157

Example 3

Ligand Competition Assays

The ability of several of the antibodies identified in Example 2 to block Activin A and GDF8 binding to ACVR2A or ACVR2B was assessed by ELISA. Activin A (R&D systems) and GDF8 (R&D systems) were coated on 384-well Immunolon plates in 1× coating buffer (SurModics) at 0.5 μg/mL. Antibodies were serially diluted in a 10-point curve starting at 1 μM in 3-fold steps. ACVR2A and ACVR2B proteins were purchased from R&D Systems and biotinylated using the EZ-Link NHS-PEG4-biotin kit (Thermo Fisher). The antibodies were pre-incubated with biotinylated human ACVR2A-Fc, mouse ACVR2A-Fc, human ACVR2B-Fc, or mouse ACVR2B-Fc at a concentration of 500 ng/mL in 1% BSA in PBST for 1 hour. The mixtures of antibodies and biotinylated receptors were added to the Activin A/GDF8-coated plates for 1 hour. The inhibition of ligand-receptor interaction was detected with streptavidin-HRP (Jackson ImmunoResearch) at a concentration of 10 ng/mL and TMB.

The results of this assay are shown in columns A-D of Table 5 below. The values shown are IC50 values. The data in this table shows that the antibodies can specifically block Activin A and GDF8 binding to ACVR2A.

Example 4

ALK5/ACVR2B DIMERIZATION ASSAY

The ability of several of the antibodies identified in Example 2 to specifically block GDF8-induced dimerization between ACVR2A and ALK5 in U2OS cells was assessed using the DiscoverX receptor dimerization assay. In these assays, two receptors are tagged with ProLink™ (PK) or Enzyme Acceptor (EA). Upon ligand-induced activation, the receptors dimerize forcing the two β-gal components to complement and create an active enzyme. Active β-gal generates a chemiluminescent signal in the presence of substrate. In these assays, approximately 5000 U2OS cells were transferred into each well in total volume of 20 ul, antibody was dispensed into each well in total volume of 5 ul, the treated cells were incubated for 3 hr at 37° C., 5 ul of GDF8 was dispensed into wells in total volume of 5 ul (final conc 100 ng/ml), the cells were incubated for 16 hr at 37° C. and 30 ul of 1× Flash detection reagent was added to each well. The reactions were incubated for 1 hr at room temperature and then read on a plate reader.

The results of this assay are shown in columns E and F of Table 5 below. The values shown are IC50 values. The data in this table shows that the antibodies block GDF8-induced dimerization of ALK5/ACVR2A but not ALK5/ACVR2B.

Example 5

Quantitative ELISA Assays

The binding of several of the antibodies identified in Example 2 to human ACVR2A, mouse ACVR2A, human ACVR2B, and mouse ACVR2B were quantified by ELISA. His-tagged recombinant proteins (Sino Biological, Inc.) were His-tagged Human ACVR2A, Mouse ACVR2A, Human ACVR2B, or Mouse ACVR2B were coated on Immunolon 384-well plates at a concentration of 0.5 μg/mL in 1× coating buffer (SurModics). Antibodies were diluted to 1 μM in PBS buffer containing 1% BSA and diluted 3-fold in a 10-point curve. Detection of the antibody binding to the antigen was performed using biotinylated goat anti-human kappa light chain (Bethyl Laboratories). Detection of the secondary antibody was determined using streptavidin-HRP and TMB reagent. All assays were performed at room temperature. Curve-fitting software was used to determine the EC50 for each antibody (MatLab).

The results of this assay are shown in columns G-L of Table 5 below. The values shown are EC50 values. The data in this table shows that the antibodies specifically bind to ACVR2A, not ACVR2B.

Example 6

Activity on Skeletal Muscle Cells

The ability of several of the antibodies identified in Example 2 to alter SMAD3 activity in muscle cells was tested. Primary human myoblasts (Lonza) cultured in Ham's F-10 supplemented with SkGM-2 Single-Quots (Lonza). Myoblasts were differentiated in DMEM/F-12K (50:50) supplemented with 2% horse serum (Corning) and 1% Penicillin/Streptomycin. After 4 days of differentiation, myotubes were pre-treated with antibodies for 1 hour at a starting concentration of 1 μM and diluted serially 3-fold in a 10-point curve. GDF8 (R&D) was added for 1 hour at 100 ng/mL. Cells were lysed in 30 μL of PBS+0.1% Triton-X+lx Halt Protease/Phosphastase inhibitors (Thermo Fisher). Phospho-SMAD3 (Ser423/425) activity was assessed in primary human myotubes by AlphaLisa (Perkin-Elmer) according to manufacturer's instructions.

The results of this assay are shown in column M of Table 5 below. The data in this table shows that the antibodies reduce GDF8-induced SMAD3 phosphorylation in muscle cells.

Example 7

Smad Reporter 293 Assay

The ability of several of the antibodies identified in Example 2 to specifically inhibit GDF8-induced SMAD activation in HEK293 was tested cells using a smad2/3 luciferase reporter construct. In these experiments, a smad2/3 luciferase reporter (SBI #TR203VA-P) was introduced into HEK293 cells. Endogenous ACVR2A and ACVR2B function was knocked out using custom made CRISPR/CAS9 targeting sequences. Finally, individual reporter lines were generated by reintroduction of ACVR2A or ACVR2B expression vectors. This method involved dispensing 30,000 cells into each well in total volume of 80 ul, dispensing antibody into each well in total volume of 10 ul, incubating the treated cells for 1 hr at 37° C., dispensing GDF8 into wells in total volume of 10 ul (final conc. 100 ng/ml), incubating the stimulated cells for 24 hr at 37° C., adding 100 ul of 1X ONE-Glo detection reagent to each well, incubate the plate for 5 min at room temperature and then reading luminescence using a plate reader.

The results of this assay are shown in column N of Table 5 below. The values shown are IC50 values. The data in this table shows that the antibodies inhibit GDF8-induced SMAD3 phosphorylation in HEK293 cells.

Example 8

Smad Reporter 4E1 Assay

The ability of several of the antibodies identified in Example 2 to specifically inhibit GDF8-induced SMAD activation was tested cells using the following protocol. In this assay, HEK293 cells were infected with a lentiviral SMAD2/3/4 reporter (pGF-SMAD2/3/4-mCMV-EF1-Puro System Biosciences). The lentiviral based reporter expresses both GFP and luciferase under the control of a Smad3-responsive element (CAGA)₁₂. Cells were sorted for their responsiveness to GDF8 based on their GFP expression. Single cell clones were expanded and transcriptional activation was tested by GDF8-induced luciferase activity. Clone 4E1 was unresponsive to GDF8 or Activin A. This clone was further transfected with Human or Mouse ACVR2A or ACVR2B plasmids. The ability of the antibodies to inhibit luciferase induction by GDF8 or Activin A in these cell lines was tested.

The results of this assay are shown in column 0 of Table 5 below. These values are IC50 values. The data in this table shows that the antibodies inhibit GDF8 and Activin A-mediated induction of SMAD2/3/4 in HEK293 cells.

TABLE 5
	A	B	C	D	E	F	G	H	I	J	K	L	M
	Comp ELISA	Comp ELISA	Comp ELISA	Comp ELISA	Dimer	Dimer	ELISA	ELISA-	ELISA-	ELISA	ELISA	ELISA	Phospho-	N	O
	Human	Human	Mouse	Mouse	ALK5/	ALK5/	Human	Human	Human	Mouse	Mouse	Mouse	SMAD3	SMAD 2/3/4	Clone 4E1 +
	ACVR2A	ACVR2A	ACVR2A	ACVR2A	ACVR2A	ACVR2B	ACVR2A	ACVR2A	ACVR2B	ACVR2A	ACVR2A	ACVR2B	Human Skeletal	Reporter	Human ACVR2A,
Ab	Activin A	GDF8	Activin A	GDF8	GDF8	GDF8	(10 pt)	(8 pt)	(10 pt)	(10 pt)	(8 pt)	(10 pt)	Muscle GDF8	HEK293	Activin A, 10pt
365_B10	0.0819	0.0009	0.0066	0.0002	0.6247	9999	0.0013	0.001	9999	0.001	0.0009	9999	0.031	0.3643	0.0364
365_E04								0.004			0.0048
365_H08	0.4151	0.0116	0.1949	0.0044	9999	9999	0.1963	0.0089	9999	0.0959	0.0055	9999		9999	9999
366_D01	0.338	0.0292	0.2896	0.0133	6.372	9999	0.0017		9999	0.0011		9999	0.1323	0.4973	0.1006
366_G06								0.0059			0.0041
367_H01	0.0363	0.0035	0.0125	0.0014	6.578	9999	0.0064	0.0009	9999	0.0054	0.0025	9999	0.0248	3.679	0.3607
368_A02								0.008			0.008
368_A12	0.081	0.002	0.0348	0.0007	2.303	9999	0.0016	0.0028	9999	0.0015	0.0024	9999	0.046	0.9454	0.1142
368_B10	0.0077	0.0025	0.0084	0.0032	0.4969	9999	0.0053	0.0043	9999	0.0053	0.0045	9999	0.0469	1.387	0.0632
368_F10	0.1033	0.0069	0.1028	0.004	3.946	9999	0.0039		9999	0.0022		9999	0.2567	0.8681	0.2092
369_B03	0.0164	0.0044	0.0115	0.0033	1.761	9999	0.0051	0.0031	9999	0.006	0.0024	9999	0.0157	0.3055	0.1569
369_H03	0.1782	0.0017	0.0246	0.0001	8.179	9999	0.0073	0.003	9999	0.0052	0.01	9999	0.3262	9999	0.0957
370_B01	0.0036	0.0006	0.0027	0.0004	0.1589	9999	0.0004	0.0011	9999	0.0004	0.001	9999	0.0121	0.0535	0.0154
371_D07	0.0271	0.0032	0.0344	0.0035	1.182	9999	0.0093	0.013	9999	0.0057	0.01	9999	0.1265	4.187	0.2217
372_B11	0.0623	0.0059	0.0718	7.11E−05	2.191	9999	0.0042		9999	0.0032		9999	0.3973	4.276	0.2726
373_E11	0.0208	0.0012	0.021	8.31E−05	0.9392	9999	0.0013		9999	0.0012		9999	0.0229	0.4333	0.1403
373_H02	0.01	0.0036	0.006	0.0032	0.7633	9999	0.0032	0.001	9999	0.003	0.0011	9999	0.0145	0.3413	0.0251
374_B02	0.1374	0.0206	0.0771	0.0112	5.938	9999	0.0653	0.01	9999	0.0378	0.0032	9999	0.1183	9999	0.1766
375_A04	0.0025	0.0015	0.0018	0.0011	0.0481	9999	0.0007	0.0006	9999	0.0007	0.0004	9999	0.0076	0.0551	0.0071
375_A11	0.0167	0.0082	0.0105	0.0047	0.939	9999	0.0047	0.0009	9999	0.003	0.0007	9999	0.0127	0.5299	0.0359
375_H01								0.015			0.015
376_G02	0.0144	0.0051	0.0111	0.0041	0.8281	9999	0.0029	0.0018	9999	0.002	0.002	9999	0.1901	0.3337	0.0836
365_G06	0.0151	0.0034	0.0226	0.0028	0.4743	9999	0.0035	0.0026	9999	0.0031	0.0073	9999	0.0875	0.2124	0.0309
367_F10	0.0186	0.0035	0.0168	0.0026	2.249	9999	0.0019	0.0136	9999	0.0017	0.0119	9999	0.1176	0.4684	0.369
368_B12	0.0074	0.0035	0.0128	0.0033	0.4249	9999	0.0047	0.0053	9999	0.0051	0.006	9999	0.0918	1.746	0.1613
369_A12	0.0205	0.0005	0.0119	0.0002	0.3311	9999	0.001	0.0017	9999	0.0008	0.0014	9999	0.0119	0.0948	0.0311
369_E03	0.0777	0.0006	0.0346	0.0049	0.8456	9999	0.001	0.0059	9999	0.0009	0.0043	5.543	0.0235	1.043	0.1305
370_B06	0.018	0.0007	0.0107	0.0002	0.9481	9999	0.0032	0.0018	9999	0.0023	0.0015	9999	0.0061	0.3843	0.0467
371_B11	0.0268	0.0038	0.0147	0.157	0.3699	9999	0.0011	0.0012	9999	0.001	0.0011	9999	0.015	0.2384	0.0316
371_C02	0.0519	0.0043	0.0577	0.0087	3.394	9999	0.0025	0.0045	9999	0.0021	0.0045	9999	0.0488	1.01	0.0956
373_D11	0.0037	0.0005	0.004	0.0001	0.1968	9999	0.0003		9999	0.0003		9999	0.0081	0.3066	0.0225
373_G06	0.0478	0.0053	0.0325	0.0044	9999	9999	0.0052	0.0009	9999	0.0047	0.0021	9999	0.0231	1.969	0.0383
376_D08	0.0027	0.0007	0.0019	0.0007	0.075	9999	0.0006		9999	0.0005		9999	0.0065	0.0343	0.41
376_F09	0.0094	0.0015	0.0101	0.0016	0.3541	9999	0.0046	0.0046	9999	0.0041	0.0028	9999	0.0855	0.4007	0.0407
365_E12								0.0019			0.0017
365_F02	0.0077	0.0022	0.0078	0.0014	0.2793	9999	0.0006	0.0005	9999	0.0006	0.0005	9999	0.026	0.8487	0.0639
365_G05								0.0073			0.0072
367_A03								0.0136			0.0132
367_C07	0.0298	0.0042	0.03	0.0041	1.082	9999	0.0008		9999	0.0007		9999	0.0716	9999	0.1569
369_A07	0.0056	0.0039	0.0029	0.0013	0.5726	9999	0.001	0.0005	9999	0.0008	0.0006	9999	0.0149	0.1323	0.0155
369_B05								0.0027			0.0018
370_A02								0.0022			0.005
370_H02	0.0254	0.0005	0.0123	1.00E−14	0.9495	9999	0.0009	0.0016	9999	0.0008	0.0012	9999	0.0226	0.6343	0.0355
371_A10								0.0058			0.0056
371_C12	0.043	0.0004	0.024	0.0043	0.3096	9999	0.0006	0.0011	9999	0.0005	0.0007	9999	0.0206	0.5658	0.0187
371_D02								0.0028			0.0017
371_G09								0.0019			0.0019
371_G11	0.0062	0.0004	0.0066	0.0045	7.363	9999	0.0042	0.0039	9999	0.0034	0.0031	9999	0.1361	9999	0.3384
372_B02	0.0099	0.0001	0.0045	0.0004	2.192	9999	0.0019	0.0026	9999	0.0014	0.0017	9999	0.1605	1.675	0.1778
372_D03	0.003	0.0004	0.0013	0.0006	0.7064	9999	0.0011	0.0012	9999	0.0009	0.0009	9999	0.058	0.1379	0.0466
373_A03	0.0053	0.0023	0.0031	0.0021	0.2914	9999	0.001	0.001	9999	0.0008	0.0007	9999	0.0148	0.559	0.009
373_A05								0.0032			0.0022
373_A09								0.0012			0.0009
373_A11								0.0009			0.0006
373_B05								0.0022			0.0021
373_C07	0.0126	0.004	0.0087	0.0011	1.215	9999	0.0028	0.0015	9999	0.0025	0.0014	9999	0.0048	1.208	0.0686
373_F08	0.0022	0.0015	0.0017	0.0004	0.0919	9999	0.0006	0.0007	2.32	0.0004	0.0005	2	0.005	0.3677	0.0315
373_F12								0.0016			0.0009
373_G08	0.0041	0.0012	0.0033	0.001	0.2649	9999	0.0009	0.001	9999	0.0007	0.0009	9999	0.0057	0.3073	0.0711
373_H03	0.0199	0.0074	0.0117	0.0066	2.093	9999	0.003		9999	0.0024		9999	0.0129	0.808	0.1144
374_B03	0.0031	0.0015	0.002	0.0006	0.2057	9999	0.0008	0.0009	9999	0.0008	0.0006	9999	0.027	0.2394	0.0399
374_C01	0.3127	0.0191	0.2885	0.0033	9999	9999	0.022		9999	0.0263		9999	1.115	0.8145	4.942
374_C09	0.0467	0.0088	0.0496	0.0047	1.402	9999	0.011	0	9999	0.007	0.004	9999	0.1888	0.7011	0.2959
374_C12	0.0045	0.0023	0.0038	0.0026	0.2619	9999	0.0016	0.0005	0.4162	0.0012	0.0005	0.397	0.027	0.1579	0.083
374_D05	0.0392	0.0065	0.0258	0.0068	1.646	9999	0.0074	0.0022	9999	0.0066	0.0018	9999	0.0177	1.697	0.0851
374_D10	0.0781	0.0038	0.0653	0.0027	3.186	9999	0.0032		1.021	0.0022		1.053	0.1264	9999	4.658
374_G08	0.0056	0.0025	0.0056	0.0017	0.608	9999	0.0018	0.0009	9999	0.0014	0.0009	9999	0.034	0.542	0.0781
375_A01								0.0012			0.001
375_A07	0.0097	0.0025	0.0221	0.0025	0.4117	9999	0.001		9999	0.001		9999	0.014	0.0154	0.0922
375_A12	0.0047	0.0011	0.0033	0.0003	0.3345	9999	0.0007		9999	0.0005		9999	0.0469	1.051	0.0415
375_D10								0.0023			0.0019
375_E05								0.0009			0.0007
375_E10	0.0036	0.002	0.0023	0.0009	0.2255	9999	0.0007	0.0006	9999	0.0007	0.0006	9999	0.0091	0.2237	0.0215
375_F02	0.0288	0.0034	0.0184	0.006	0.8957	9999	0.0037		9999	0.0028		9999	0.0076	0.6181	0.0247
375_G05	0.0008	0.0005	0.001	0.0004	0.1347	9999	0.0005	0.0007	2.852	0.0004	0.0005	2	0.0052	0.0108	0.0668
375_H05	0.0067	0.0019	0.0043	9.34E−05	0.4237	9999	0.0008	0.0006	9999	0.0007	0.0005	9999	0.0346	0.2948	0.0342
376_A03								0.0022			0.0014
376_B10								0.0021			0.0017
376_C08	0.0243	0.0046	0.0272	0.0046	0.9254	9999	0.0044		9999	0.0048		9999	0.0605	1.353	0.1794
376_F01	0.1328	0.0177	0.1264	0.0177	2.893	9999	0.0076	0.0082	0.0922	0.008	0.003	0.0924	0.5947	9999	0.6449
376_F06	0.0352	0.0032	0.021	0.002	0.5714	9999	0.0034	0.0024	9999	0.0032	0.0017	9999	0.0544	9999	0.1295
375_G05	0.0081	0.0036	0.008	0.0032	0.9329	9999	0.0017	0.0006	9999	0.0014	0.0005	9999	0.0658	0.3712	0.0755
376_G10								0.0031			0.0032
376_H01	0.005	0.0025	0.0044	0.0013	0.5641	9999	0.001	0.0012	0.1094	0.0009	0.001	0.0981	0.0562	0.6002	0.0329
376_H11	0.0008	0.0007	0.0013	0.0007	0.0368	9999	0.0004	0.0005	9999	0.0004	0.0004	9999	0.0042	0.0775	0.0084
367_A02	0.0685	0.0168	0.0757	0.0117	1.404	9999	0.0099		9999	0.0053		9999	0.1591	2.765	0.065
368_G03	0.1025	0.0013	0.0477	0.0003	5.011	9999	0.0033	0.0068	9999	0.0026	0.008	9999	0.299	1.678	0.4619
368_H06								0.0138			0.0023
369_C12	0.0022	0.0007	0.0016	0.0006	0.137	9999	0.0007	0.0008	9999	0.0007	0.0005	9999	0.0094	0.0821	0.0435
369_E08								0.0028			0.0023
369_F09	0.0204	0.0007	0.0196	0.0004	0.793	9999	0.0012		2	0.001		2	0.0325	1.095	0.1356
369_H08	0.0721	0.0014	0.0431	0.0002	1.385	9999	0.0013	0.0034	9999	0.001	0.0025	9999	0.0308	0.7511	0.074
369_H12	0.0154	0.001	0.0112	0.0001	1.812	9999	0.0006	0.0011	9999	0.0005	0.001	9999	0.0303	0.3774	0.0815
370_C06	0.0148	0.0005	0.0083	6.83E−05	0.7631	9999	0.0005	0.0009	9999	0.0005	0.0008	9999	0.0111	4999	0.05
370_C07	0.0219	0.0011	0.0064	0.0006	0.3774	9999	0.0006	0.0006	9999	0.0006	0.0005	9999	0.0044	0.1452	0.0213
370_D03	0.0163	0.0025	0.0103	0.0042	0.8872	9999	0.0023	0.0017	9999	0.0017	0.0015	9999	0.0165	0.4708	0.0649
370_E04	0.0067	0.0023	0.0065	0.0005	0.8152	9999	0.0008	0.0007	9999	0.0008	0.0005	9999	0.0136	0.5966	0.0416
370_F12	0.005	0.0002	0.0025	2.65E−05	0.3859	9999	0.0009	0.0006	9999	0.0007	0.0005	9999	0.0066	0.1268	0.0096
371_B01	0.003	0.0006	0.0024	0.0002	0.1059	9999	0.0005	0.0017	9999	0.0005	0.0018	9999	0.0076	0.0454	0.0091
371_E12	0.0023	0.0043	0.0022	0.0024	0.5962	9999	0.0012		9999	0.0011		9999	0.0374	0.3155	0.1173
371_F09	0.0054	0.0006	0.0047	0.0003	0.2882	9999	0.0006		9999	0.0005		9999	0.0311	0.31	0.0405
371_G01								0.0013			0.0012
371_H11								0.0011			0.0008
372_B09	0.0022	0.0002	0.0007	0.0003	0.6034	9999	0.0006	0.0009	9999	0.0006	0.0008	9999	0.0182	0.4639	0.055
372_D06	0.0085	0.001	0.0083	0.0003	0.3887	9999	0.0004		9999	0.0003		9999	0.0303	0.4069	0.0807
373_F07	0.0091	0.002	0.0056	0.0039	3.811	9999	0.0015		9999	0.0014		9999	0.0069	0.397	0.0413
374_A05	0.0023	0.0002	0.0021	0.0005	0.0998	9999	0.0003	0.0008	9999	0.0003	0.0006	9999	0.0081	0.2057	0.0166
374_C10	0.0137	0.003	0.0064	0.0023	0.4673	9999	0.001	0.0013	9999	0.0007	0.001	9999	0.0582	0.0544	0.3012
374_G05	0.0074	0.002	0.0042	0.0027	0.5471	9999	0.0021	0.0006	9999	0.0017	0.0006	9999	0.0132	0.4163	0.0192
365_A12	0.3112	0.0015	0.1194	5.64E−05	9999	9999	0.0103	0.0084	0.7569	0.0059	0.0071	0.3945	0.9032	5.406	1.133
365_B11								0.003			0.0032
365_E05	0.0435	0.0098	0.0528	0.0071	0.8445	9999	0.0045		9999	0.0042		9999	0.2437	0.367	0.0548
365_E07	0.3702	0.0105	0.1501	0.0122	9999	9999	0.011	0.008	9999	0.0048	0.0101	9999	0.5183	9999	0.9486
366_B12	0.0304	0.0115	0.0185	0.0114	0.8558	9999	0.0012	0.0013	9999	0.0009	0.001	9999	0.0392	0.3748	0.053
367_F03								0.01			0.007
367_H06	0.0744	0.0035	0.0653	0.0034	0.8666	9999	0.0018		9999	0.0012		9999	0.108	0.9681	0.3781
367_H11	0.0389	0.0044	0.0258	0.0035	0.4515	9999	0.0057	0.004	9999	0.003	0.0008	9999	0.0703	1.207	0.118
368_F03	0.4171	0.0005	0.0323	0.0001	9999	9999	0.022	0.1	9999	0.0189	0.1503	9999	0.8118	3.259	3.216
369_D02	0.0031	0.0006	0.0039	2.58E−05	0.2671	9999	0.0004		9999	0.0004		9999	0.0135	0.1746	0.0252
369_F01	0.0147	0.0013	0.0147	0.0002	0.4998	9999	0.0008		9999	0.0007		9999	0.0317	0.5266	0.1112
369_F06								0.0038			0.0032
369_G01	0.0112	0.0008	0.0061	0.0001	0.7538	9999	0.0004		9999	0.0004		9999	0.0116	0.1187	0.0275
369_H06	0.0106	0.0028	0.0082	3.81E−05	9999	9999	0.0005	0.0004	9999	0.0005	0.0002	9999	0.0068	9999	0.0225
370_A01								0.0045			0.0039
370_A12	0.0061	0.0023	0.0136	0.0024	0.1245	9999	0.0009	0.0016	9999	0.0008	0.0015	9999	0.0632	0.031	0.0036
370_C01								0.0017			0.0015
370_C03	0.0007	0.0004	0.0006	0.0004	0.0388	9999	0.0004	0.0003	9999	0.0004	0.0004	9999	0.0029	0.0133	0.0035
370_C05	0.0053	0.0032	0.0036	0.0024	0.927	9999	0.0012	0.0033	9999	0.0011	0.0024	9999	0.0082	0.2655	0.0343
370_C08								0.021			0.0016
370_D04	0.0055	0.0012	0.0038	0.0013	0.1029	9999	0.0005	0.0007	9999	0.0004	0.0006	9999	0.0074	0.0452	0.0153
370_E09	0.0043	0.0009	0.0021	0.0006	0.2656	9999	0.0006	0.0007	9999	0.0005	0.0006	9999	0.0093	0.1226	0.009
370_H01	0.0084	0.0006	0.0056	2.61E−05	2.84	9999	0.0005	0.0004	9999	0.0005	0.0003	9999	0.0093	4999	0.039
371_A06								0.0014			0.0014
371_B07	0.0161	0.0023	0.0155	0.0003	1.236	9999	0.0012	0.0014	1.77	0.0011	0.0012	9999	0.0402	0.4951	0.0734
371_F01								0.005			0.0046
371_F04								0.0023			0.0022
372_A04	0.0031	0.0028	0.0051	0.0022	0.3792	9999	0.0008		9999	0.0007		9999	0.0193	0.0367	0.0423
372_D02								0.0029			0.0027
372_F03	0.0047	0.0005	0.0041	0.0002	0.1903	9999	0.0003	0.0008	9999	0.0004	0.0008	9999	0.0646	0.1972	0.0233
372_F08	0.0031	0.0113	0.0026	0.0113	0.371	9999	0.0009		9999	0.0008		9999	0.023	0.3148	0.0248
372_F09	0.0053	0.0002	0.0113	0.0029	1.012	9999	0.001	0.0009	9999	0.0009	0.0008	9999	0.018	1.8	0.087
373_A10	0.0028	0.002	0.0055	0.0018	0.3578	2.53	0.0006		9999	0.0006		9999	0.0111	0.0965	0.0534
373_B04	0.0186	0.0023	0.0103	0.0031	1.268	9999	0.0026	0.0018	9999	0.0027	0.0013	9999	0.0093	1.028	0.1154
373_C02	0.0302	0.0052	0.0179	0.0022	3.29	9999	0.0053		9999	0.0052		9999	0.0083	1.389	0.1045
373_C06								0.001			0.001
373_D04	0.0019	0.0013	0.0023	0.0012	0.1467	9999	0.0006		9999	0.0005		9999	0.0078	0.137	0.0189
373_D10	0.0069	0.0018	0.0033	0.0004	0.2803	9999	0.0015	0.0008	9999	0.0012	0.0005	9999	0.006	0.0821	0.0176
374_B04	0.0043	0.0018	0.0029	0.0016	0.2473	9999	0.0014	0.0003	9999	0.0015	0.0003	9999	0.0093	0.1014	0.0156
374_B06	0.0614	0.0041	0.0513	0.0001	0.5987	9999	0.0011	0.004	9999	0.0009	0.004	9999	0.0407	0.3649	0.0717
374_C03	0.0016	0.001	0.0026	0.0007	0.1284	9999	0.0005		9999	0.0004		9999	0.0094	0.0468	0.0144
374_C06	0.0105	0.0039	0.0059	0.0032	0.5205	9999	0.0019	0.0008	9999	0.0015	0.0007	9999	0.0138	0.296	0.015
374_D08	0.9536	0.0698	0.6104	0.0621	9999	9999	0.3558	0.01	9999	0.2008	0.01	9999	0.2299	9999	1.286
374_E01								0.0013			0.001
374_E05	0.0074	0.0023	0.0079	0.0019	0.3051	9999	0.0013	0.0016	0.1534	0.0014	0.0011	0.1414	0.0497	0.6496	2.729
365_E02	0.4962	0.0046	0.1616	0.0012	12.07	9999	0.0095	0.008	9999	0.0047	0.0013	9999	0.3412	9999	0.4773
376_C06	0.0349	0.0049	0.0238	0.0053	0.711	9999	0.0042	0.0016	9999	0.0022	0.001	9999	0.0107	0.1983	0.0817
368_D10	0.0119	0.0045	0.0195	0.0033	0.4824	9999	0.0019		9999	0.0014		9999	0.0601	0.2942	0.0389
374_C08	0.182	0.0325	0.194	0.0223	9999	9999	0.0462		9999	0.0285		9999	0.5848	9999	9999
376_A06	0.0011	0.0006	0.0009	0.0004	0.0189	9999	0.0004	0.0004	9999	0.0004	0.0003	9999	0.0043	0.0203	0.0037
365_F07	0.0044	0.0017	0.0037	0.0006	0.136	9999	0.0012	0.0006	9999	0.0013	0.0007	9999	0.011	0.0925	0.0354
376_B01	0.0035	0.0006	0.0039	8.50E−05	0.2036	9999	0.0004		9999	0.0004		9999	0.0086	0.369	0.0283
365_D05	0.0146	0.0025	0.0149	0.0009	0.9169	9999	0.0008		9999	0.0008		9999	0.0209	0.6678	0.1817
369_G07	0.0068	0.001	0.0075	0.0001	9999	9999	0.0007		9999	0.0006		9999	0.012	0.0327	0.1333
373_G05	0.0023	0.0002	0.0021	0.0002	0.1636	9999	0.0003		9999	0.0002		9999	0.0059	0.1546	0.0202
376_B06	0.0016	0.001	0.0014	0.0007	0.0381	9999	0.0005	0.0006	9999	0.0005	0.0004	9999	0.0042	0.0005	0.0164
374_C11	0.0192	0.0015	0.0105	0.0034	0.9402	9999	0.0018		0.3945	0.0015		0.3304	0.0266	0.6324	0.0328
375_A06	0.0032	0.0016	0.0025	0.0013	0.1302	9999	0.0012	0.0005	9999	0.0011	0.0004	9999	0.0318	0.1546	0.014
373_E06	0.0002	0.0002	0.0002	0.0001	0.0082	9999	0.0002	0.0002	9999	0.0002	0.0002	9999	0.0005	0.0089	0.0022
374_C05	0.0009	0.0005	0.0011	0.0004	0.1344	9999	0.0007	0.0005	9999	0.0007	0.0004	9999	0.0124	0.0142	9999
368_H01								0.0017			0.0014
373_B03								0.0006			0.0005
369_A10	0.017	0.0005	0.0077	8.47E−05	5000	9999	0.001	0.0015	9999	0.001	0.0005	9999	0.0076	5000	0.071
366_A05					0.7418	9999	0.0004	0.0006	9999	0.0005	0.0005	9999	0.0244	0.6492	0.0524
375_G07	0.0085	0.0032	0.0053	0.0031	0.7814	9999	0.0022	0.0012	9999	0.0016	0.001	9999	0.0112	0.2215	0.0786
371_G03								0.001			0.001
370_E07	0.0009	0.0005	0.0013	0.0005	0.1001	9999	0.0007	0.0003	9999	0.0008	0.0003	9999	0.0046	0.0764	0.013
367_G07	0.0007	0.0009	0.0011	0.0007	0.1113	9999	0.0011	0.0005	9999	0.0009	0.0004	9999	0.0068	0.0843	0.0124
375_C12	0.0006	0.0003	0.0007	0.0004	0.0414	9999	0.0004	0.0003	0.4421	0.0004	0.0003	0.4194	0.0063	0.0237	0.2784
373_B08	0.003	0.0012	0.002	0.0012	0.3478	9999	0.0015	0.0005	9999	0.0017	0.0004	9999	0.0102	0.1201	0.017
374_A11	0.0038	0.0015	0.0027	0.0015	0.6038	9999	0.0013	0.0004	9999	0.0011	0.0003	9999	0.0086	0.079	0.0188
373_B11	0.0003	0.0002	0.0005	0.0003	0.0185	9999	0.0002		9999	0.0003		9999	0.0008	0.024	0.0036
372_D04	0.0022	0.0008	0.0026	0.0317	0.1255	9999	0.0009	0.0005	9999	0.0009	0.0005	9999	0.0114	0.0938	0.0179
367_A01	0.0021	0.0009	0.0041	0.0011	0.1471	9999	0.0012	0.0009	9999	0.0011	0.0007	9999	0.0065	0.1617	0.0355
373_E02	0.0034	0.0013	0.0021	0.0013	4999	9999	0.0012	0.0006	9999	0.0012	0.0005	9999	0.0049	4999	4999

While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto.

Claims

1. An antibody that specifically binds to ACVR2A, wherein the antibody comprises:

(a) a variable domain comprising: i. heavy chain CDR1, CDR2 and CDR3 regions that are identical the heavy chain CDR1, CDR2 and CDR3 regions of an antibody selected from any of Tables 2A-2F; and ii. light chain CDR1, CDR2 and CDR3 regions that are identical the light chain CDR1, CDR2 and CDR3 regions of the antibody selected from any of Tables 2A-2F; or

(b) a variant of said variable domain of (a) that is otherwise identical to said antibody variable domain except for up to 15 amino acid substitutions in said CDR regions.

2. An antibody that specifically binds to ACVR2A, wherein the antibody comprises:

a heavy chain variable domain comprising: a heavy chain framework, a CDR1 region, a CDR2 region, and a CDR3 region of sequence AxxAxWHDTxLD (SEQ ID NO: 6618); and

a light chain variable domain comprising: a light chain framework, a CDR1 region, a CDR2 region, and a CDR3 region.

3. The antibody of claim 1, wherein the heavy chain variable domain comprises a CDR3 region of sequence ARSATWHDTxLD (SEQ ID NO: 6549), ARAATWHDTxLD (SEQ ID NO: 6540), ARGANWHDTxLD (SEQ ID NO: 6542), ARGATWHDTxLD (SEQ ID NO: 6544), ARSANWHDTxLD (SEQ ID NO: 6546) or ARSATWHDTxLD (SEQ ID NO: 6548).

4. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6619), and iii. a CDR3 region that has a sequence of ARAANWHDTA/HLD (SEQ ID NO: 6620); and

a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6554), ii. a CDR2 region that has a sequence of LV/LIYA/YNA/V/TT/S/NS/NR/LA/H/Q/P (SEQ ID NO: 6621), and iii. a CDR3 region that has a sequence of QQ/HSY/DD/E/S/NL/N/S/TPL (SEQ ID NO: 6593).

5. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYG/SMH/N (SEQ ID NO: 6550), ii. a CDR2 region that has a sequence of WVA/SS/G/NINYNG/SGYT/KS/G (SEQ ID NO: 6551), and iii. a CDR3 region that has a sequence of ARAATWHDTH/ALD (SEQ ID NO: 6559); and

a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561), ii. a CDR2 region that has a sequence of LL/VIYA/YA/T/VT/S/NS/NR/LA/P/Q (SEQ ID NO: 6563), and iii. a CDR3 region that has a sequence of QQSY/D/ND/E/S/NL/S/T/NPL (SEQ ID NO: 6565).

6. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6566), ii. a CDR2 region that has a sequence of WVS/AG/S/NINYNG/SGYT/KS/G (SEQ ID NO: 6567), and iii. a CDR3 region that has a sequence of ARGANWHDTA/HLD (SEQ ID NO: 6543); and

a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/S/IS/TYL/VNWY (SEQ ID NO: 6569), ii. a CDR2 region that has a sequence of LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571), and iii. a CDR3 region that has a sequence of QQSY/DD/E/S/NS/T/N/LPL (SEQ ID NO: 6573).

7. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYS/GMN/H (SEQ ID NO: 6574), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6575), and iii. a CDR3 region that has a sequence of ARGATWHDTH/ALD (SEQ ID NO: 6595); and

a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/I/V/SS/TYL/VNWY (SEQ ID NO: 6596), ii. a CDR2 region that has a sequence of LL/VIYAA/V/TT/SSR/LA/H/Q (SEQ ID NO: 6571), and iii. a CDR3 region that has a sequence of QQSY/DD/E/S/NT/S/N/LPL (SEQ ID NO: 6577).

8. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of S/DS/DYG/SMN/H (SEQ ID NO: 6578), ii. a CDR2 region that has a sequence of WVS/AG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6579), and iii. a CDR3 region that has a sequence of AR/KSANWHDTA/HLD (SEQ ID NO: 6580); and

a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/TYL/VNWY (SEQ ID NO: 6561), ii. a CDR2 region that has a sequence of LL/VIYA/YAN/TT/SS/NR/LA/H/Q (SEQ ID NO: 6582), and iii. a CDR3 region that has a sequence of QQSY/DD/E/N/SS/T/L/NPL (SEQ ID NO: 6598).

9. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising: i. a CDR1 region that has a sequence of D/SS/DYS/GMN/H (SEQ ID NO: 6584), ii. a CDR2 region that has a sequence of WVA/SG/N/SINYNG/SGYT/KS/G (SEQ ID NO: 6585), and iii. a CDR3 region that has a sequence of ARSATWHDTH/ALD (SEQ ID NO: 6586); and

a light chain variable domain comprising: i. a CDR1 region that has a sequence of L/V/I/SS/T/RYL/VNWY (SEQ ID NO: 6588), ii. a CDR2 region that has a sequence of LL/VIYA/YAN/TT/SS/NR/LA/H/Q (SEQ ID NO: 6590), and iii. a CDR3 region that has a sequence of QQSY/DD/E/S/NL/N/T/SPL (SEQ ID NO: 6591).

10. The antibody of claim 1, wherein the antibody comprises:

a heavy chain variable domain comprising an amino acid sequence that is at least 80% identical to the amino acid sequence of the heavy chain variable domain of an antibody selected from any of Tables 2A-2F; and

a light chain variable domain comprising an amino acid sequence that is at least 80% identical to the light chain variable domain of the antibody selected from any of Tables 2A-2F.

11. The antibody of claim 1, wherein the heavy chain variable domain and the light chain variable domain are present in separate polypeptides.

12. The antibody of claim 1, wherein the heavy chain variable domain and the light chain variable domain are present in a single polypeptide.

13. The antibody of claim 1, wherein the antibody binds ACVR2A with an affinity in the range of 107 M−1 to 1012 M−1.

14. The antibody of claim 1, wherein the antibody comprises a covalently linked non-peptide synthetic polymer.

15. The antibody of claim 14, wherein the synthetic polymer is poly(ethylene glycol) polymer.

16. The antibody of claim 1, wherein the antibody comprises a covalently linked lipid or fatty acid moiety.

17. The antibody of claim 1, wherein the antibody comprises a covalently linked polysaccharide or carbohydrate moiety.

18. The antibody of claim 1, wherein the antibody is a single chain Fv (scFv) antibody.

19. The antibody of claim 18, wherein the scFv is multimerized.

20-22. (canceled)

23. A method of treating a condition in a patient comprising administering to a patient in need thereof an effective amount of the antibody of claim 1.

24. The method according to claim 23, wherein the condition is associated with muscle atrophy.

25. The method according to claim 23, wherein the condition is characterized by a decrease in muscle mass or muscle function, or insufficient lean body mass.

26. The method according to claim 23, wherein the condition is cachexia or sarcopenia.