PROCESS FOR THE PREPARATION OF ALPHA,OMEGA-ALKANEDIOL MONONITRATE

The invention relates to a safe and efficient process for the hydrolysis of α,ω-C3-10alkanediol mononitrate monoacylates. The process is safer to operators and allows to obtain advantageous yields on industrial scale.

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Description

The invention relates to a safe and efficient process for the manufacture of ω-nitrooxy-C3-10alkane-1-ols.

Global temperature is increasing, a process referred to as global warming or climate change. One of the main focuses to reduce this warming effect is to reduce the amount of greenhouse gases emitted into the atmosphere. Greenhouse gases are emitted from several different sources, both natural and anthropogenic; however, the two sources with the biggest impact are the agricultural and fossil fuel industries. Within agriculture, ruminants and in particular cattle are the major contributors to the biogenic methane formation, and it has been estimated that the prevention of methane formation from ruminants would almost stabilize atmospheric methane concentrations.

3-Nitrooxypropanol (3-NOP, also known as 3-nitrooxy-propan-1-ol or 1,3-propanediol mononitrate) has been reported to be highly efficient in reducing the formation of methane in ruminants without affecting microbial fermentation in a way that would be detrimental to the host animal (WO-2012/084629). Furthermore, WO-2012/084629 discloses the preparation of 3-nitrooxypropanol by reacting 3-bromopropanol in acetonitrile with silver nitrate, a process which is, however, not economical in industrial scale production.

A potential route for industrial scale production of ω-nitrooxy-C3-10alkane-1-ols involves direct nitrate ester formation of the respective α,ω-alkanediols. This reaction, however, is often poorly selective and leads to the formation of significant amounts of dinitrated alkanediols. Furthermore, this route requires high safety measures since organic nitrates and even more dinitrates are explosive and therefore difficult to handle, even in diluted solution.

An alternative to the direct nitrate ester formation of α,ω-alkanediols is a three-step process encompassing the interim protection of one of the two alcohol groups prior to nitrate ester formation, e.g. by acetylation, followed by nitrate ester formation and consecutive removal of the respective protecting group after the nitrate ester formation step. However, even though the safety and the selectivity may thus be increased, the additional reaction steps normally lead to a significant loss in the overall yield and a substantial increase in processing cost.

Thus, there is an ongoing need for the optimization of the three-step process allowing safe and economical production of ω-nitrooxy-C3-10alkane-1-ols in large quantities starting from α,ω-alkanediols. Furthermore, there is a need for workup strategies to allow a quantitative recovery of reactants as well as solvents.

Surprisingly it has now been found that ω-nitrooxy-C3-10alkane-1-ols such as in particular 3-nitrooxypropanol can be obtained in high yields in a highly specialized three-step process, while at the same time maintaining the reaction stability and thus ensuring process safety.

Said process encompasses the consecutive steps of (a) acylation of the corresponding α,ω-alkanediol with an acylating agent, (b) nitrate ester formation of the resulting α,ω-C3-10 alkanediol monoacylate with a nitrating agent to form a α,ω-C3-10alkanediol mononitrate monoacylate followed by (c) hydrolysis of the acyl group to obtain the respective α,ω-C3-10alkanediol mononitrate and optionally (d) solvent work-up.

The individual steps (a) to (d) are novel.

Thus, in a first embodiment, the present invention relates to

    • (C) A continuous process for the two-phase hydrolysis of an α,ω-C3-10alkanediol mononitrate monoacylate, preferably 1,3-propanediol mononitrate monoacetate, said process comprising continuously feeding a base and a solution comprising the α,ω-C3-10alkanediol mononitrate monoacylate and an inert solvent, preferably an inert halogenated solvent, such as in particular dichloromethane (DCM), into a stirred cascade reactor.

In a further embodiment the present invention relates to a process for the preparation of an α,ω-C3-10alkanediol mononitrate, preferably of propanediol mononitrate, said process comprising next to step (C) outlined above the following steps: (A) and (B) before and optionally (D) after said step (C), said steps being

    • (A) Acylation of an α,ω-alkanediol with an acylation agent (acylation reaction), said acylation comprising the step of re-feeding recycled reaction components comprising α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate back into said acylation reaction, with the proviso that in the acylation reaction per mole recycled acylate groups 0.5 to 1.5 mole of water is present and that the molar ratio of the (molar) sum of the acylating agent, α,ω-C3-10alkanediol monoacylate and 2 times of α,ω-C3-10alkanediol diacylate to the sum of the α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate is selected in the range 0.5 to 1.1 mol per mol of α,ω-C3-10alkanediol, preferably in the range from 0.6 to 1 mol, most preferably in the range from 0.75 to 1 mol,
    • (B) Continuous nitrate ester formation of the α,ω-C3-10alkanediol monoacylate by reacting a nitrating agent with a solution comprising the α,ω-C3-10alkanediol monoacylate and an inert solvent in a group of pieces of equipment comprising at least two reactors in series by simultaneously feeding said solution into the first and the second reactor to obtain the respective α,ω-C3-10 alkanediol mononitrate monoacylate,
    • (D) Removal and recovery of the inert solvent from the solution by distillation, said distillation comprising partial condensation and continuous back-feeding of liquid fractions comprising mixtures of inert solvent and α,ω-C3-10 alkanediol mononitrate into said distillation.

Definition of Terms

The term ‘α,ω-C3-10alkanediols’ as used herein refers to linear α,ω-alkanediols having 3 to 10 carbon atoms such as 1,3-propanediol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,7-heptanediol, 1,8-octanediol, 1,9-nonanediol and 1,10-decanediol. The most preferred α,ω-C3-10alkanediol in all embodiments according to the present invention is 1,3-propanediol (also referred to herein as PD).

The term ‘α,ω-C3-10alkanediol monoacylate’ as used herein refers to the linear α,ω-alkanediols as defined above, wherein one of the hydroxyl groups has been esterified. Preferably, the acyl moiety is a linear or branched C1-6 acyl group, more preferably a linear or branched C1-4 acyl group such as most preferably acetyl (—C(═O)—CH3). Particularly preferred in all embodiments according to the present invention are the 1,3-propanediol monoacylates. The most preferred α,ω-C3-10alkanediol monoacylate in all embodiments of the present invention is 1,3-propanediol monoacetate (also referred to herein as PDMA).

The term ‘α,ω-C3-10alkanediol diacylate’ as used herein refers to the linear α,ω-alkanediols as defined above, wherein both of the hydroxyl groups have been esterified. Particularly preferred in all embodiments according to the present invention are the 1,3-propanediol diacylates. The most preferred α,ω-C3-10alkanediol diacylate in all embodiments of the present invention is 1,3-propanediol diacetate (also referred to herein as PDDA).

The term ‘α,ω-C3-10alkanediol mononitrate’ as used herein refers to the linear α,ω-alkanediols as defined above wherein one of the hydroxyl groups has been nitrated such 3-nitrooxypropane-1-ol (also referred to as 3-nitrooxypropanol or 3-hydroxypropyl-1-nitrate), 4-nitrooxybutane-1-ol, 5-nitrooxypentane-1-ol, 6-nitrooxyhexane-1-ol, 7-nitrooxyheptane-1-ol, 8-nitrooxyoctane-1-ol, 9-nitrooxynonane-1-ol and 10-nitrooxydecane-1-ol. Particularly preferred in all embodiments according to the present invention is 3-nitrooxypropane-1-ol (also referred to herein as propanediol mononitrate or PDMN).

The term ‘α,ω-C3-10alkanediol mononitrate monoacylate’ as used herein refers to the α,ω-C3-10alkanediol monoacylates as defined above wherein the remaining hydroxyl group has been nitrated. Particularly preferred in all embodiments according to the present invention are the 1,3-propanediol mononitrate monoacylates. The most preferred α,ω-C3-10alkanediol mononitrate monoacylate in all embodiments according to the present invention is 1,3-propanediol mononitrate monoacetate (also referred herein to as PDMNMA).

The term ‘α,ω-alkanedioldinitrates’ as used herein refers to the linear α,ω-alkanediols as defined above wherein both hydroxyl groups have been nitrated, such as 1,3-propanediol dinitrate, 1,4-butanediol dinitrate, 1,5-pentanediol dinitrate, 1,6-hexanediol dinitrate, 1,7-heptanediol dinitrate, 1,8-octanediol dinitrate, 1,9-nonanediol dinitrate and 1,10-decanediol dinitrate. Particularly preferred in all embodiments according to the present invention is 1,3-propanediol dinitrate (also referred herein to as PDDN).

The term ‘inert solvent’ (also abbreviated as ‘S’) as used herein is understood as meaning a solvent which does not take part in a chemical reaction in the reaction medium and under the operating conditions, and which is inert to both the reactants and the reaction products. In a preferred embodiment, the inert solvent is a halogenated solvent. The term ‘halogenated solvent’ means a solvent containing one or more halogen atoms and refers to any solvent selected from, but is not limited to, dichloromethane, diiodomethane, carbon tetrachloride, dichloroethane, or chloroform. Most preferably in all embodiments of the present invention, the inert solvent is dichloromethane (also referred to herein as DCM).

The term ‘consisting essentially of’ as used according to the present invention means that besides the listed components/ingredients/solvents etc. no further components are purposively added. It is however not excluded that small amount of impurities introduced by the respective raw materials may be present.

Hydrolysis

The present invention relates to a process for a two-phase hydrolysis of an α,ω-C3-10alkanediol mononitrate monoacylate (to the respective α,ω-C3-10alkanediol mononitrate), preferably of 1,3-propanediol mononitrate monoacetate to 1,3-propanediol mononitrate, said process comprising continuously feeding a base and a solution comprising an α,ω-C3-10alkanediol mononitrate monoacylate and an inert solvent such as in particular dichloromethane (DCM) into a stirred cascade reactor.

In the following, the solution comprising an α,ω-C3-10alkanediol mononitrate monoacylate and an inert solvent is also referred to as HS-I (e.g. in FIG. 3).

The hydrolysis processes according to the present invention can be carried out batch wise or continuously. Preferably, the hydrolysis process is a (fully) continuous process.

In a particular advantageous embodiment, said hydrolysis process comprises the following consecutive steps:

    • (H-1) Provision of a vertical, stirred cascade reactor setup,
    • (H-2) Continuous feeding of a solution comprising an α,ω-C3-10alkanediol mononitrate monoacylate and an inert solvent together with a base to the first (bottom) chamber (hydrolysis reactor C1 in FIG. 3),
    • (H-3) Transferring the hydrolysis reaction mixture (also referred to herein as HRM) comprising α,ω-C3-10alkanediol mononitrate, the inert solvent and the remaining base solution into a decanter or vessel (FIG. 3: C2) for phase separation to obtain an organic solution (I) comprising the α,ω-C3-10alkanediol mononitrate and the inert solvent (also referred to herein as HS-II) and an aqueous solution (also referred to herein as HS-III), followed by
    • (H-4) Collecting the organic solution (I) comprising the α,ω-C3-10alkanediol mononitrate and the inert solvent (i.e. HS-II), optionally followed by
    • (H-5) Evaporating the inert solvent from the organic solution (I) by distillation.

An exemplary (while preferred) hydrolysis according to the present invention is illustrated in FIG. 3.

In a preferred embodiment, the hydrolysis process according to the present invention further contains an additional step (H-6), comprising the steps

    • (H-6a) extracting the aqueous phase (HS-II) obtained in step (H-3) with an additional amount of the inert solvent to recover further α,ω-C3-10alkanediol mononitrate to yield an additional organic phase (II) (also referred to herein as HS-IV), and
    • (H-6b) Co-feeding said organic phase (II) into step (H-5).

The hydrolysis process is preferably carried out in (continuously) in a vessel cascade set-up or a cascade reactor, more preferably in a vertical, stirred cascade reactor. In a preferred embodiment of the invention, the hydrolysis process is performed in a vertical, stirred cascade reactor with at least 10 chambers.

For the purpose of hydrolysis process a vertical, stirred cascade reactor is a vertical reactor, that is also a stirred reactor. The term “vertical reactor” or “horizontal reactor vessel”, as used herein, means a reactor vessel having a longitudinal axis which is substantially vertical. The term “stirred reactor” as used herein, means a reactor having a means for agitating the reaction material in addition to the agitation caused by the flow (e.g., turbulent flow of the reaction material).

In a preferred embodiment of the present invention, the base used for the hydrolysis reaction of the α,ω-C3-10alkanediol mononitrate monoacylate is aqueous NaOH, the concentration of which in water is preferably selected in the range from 1 and 50 wt.-%, more preferably from 5 and 30 wt.-%, most preferably from 7.5 and 15 wt.-%.

Advantageously, the reaction temperature for the hydrolysis reaction is selected in the range from 20 to 70° C., preferably from 30 to 60° C., most preferably from 40 to 60° C.

It is furthermore advantageous that 1 to 1.5 mol equivalents, more preferably 1.1 to 1.3 mol equivalents and most preferably 1.2 to 1.3 mol equivalents of base, preferably NaOH, based on the α,ω- C3-10alkanediol mononitrate monoacylate, is used for the hydrolysis reaction.

The hydrolysis reaction is preferably carried out for a reaction time ranging from about 2 to about 6 hours, preferably from about 3 to about 5 hours, most preferably for about 4 hours.

Acylation

In a preferred embodiment, the process according to the present invention also comprises a step (A) which precedes step (C), which step (A) is directed to the acylation of an α,ω-alkanediol with an acylation agent (acylation reaction), said acylation comprising the step of re-feeding recycled reaction components into said acylation reaction as outlined above.

It is well understood, that the acylation may further comprise the steps of isolation and/or purification of the obtained α,ω-C3-10alkanediol monoacylate by the methods disclosed herein or any other suitable method in the art.

It is well understood, that the term ‘reaction components’ as used herein refers to components of the acylation reaction which take part in the acylation reaction, i.e. the α,ω-alkanediol, the α,ω-C3-10alkanediol monoacylate and the α,ω-C3-10alkanediol diacylate as well as the acylating agent and water, not encompassing, however, any solvents or other inert ingredients or additives.

In all embodiments of the present invention, the term ‘recycled reaction components’ (also abbreviated as RRC) refers to unreacted α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate as well as water and acylating agent.

It is furthermore well understood, that the recycled reaction components can be isolated separately or as any mixture thereof and thus be re-fed individually or as any mixture thereof. Preferably, the recycled reaction components consist essentially of

    • (1) a mixture of α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate (RCC-(I))
    • (2) unreacted α,ω-C3-10alkanediol (RCC-(ll)) as well as
    • (3) a mixture of water and acylating agent (RCC-(III)).

In all embodiments of the present invention it is preferred that at least the recycled reaction components RCC-(I) and RCC-(II) are admixed before being re-fed into the acylation reaction (see FIG. 1).

The acylation according to the present invention can be carried out batch wise or continuously.

Preferably, the acylation of the α,ω-alkanediols with an acylation agent according to the present invention is carried out in a reactor into which the recycled reaction components are (continuously) re-fed.

Suitable reactors include any type of vessel, such as stirred tank reactors, cascade reactors, loop reactors, tubular reactors, without being limited thereto.

In a particular embodiment, the acylation according to the present invention further comprises the step of separation of the obtained α,ω-C3-10alkanediol monoacylate by distillation, preferably in a way such that

    • the amount of α,ω-C3-10alkanediol in the α,ω-C3-10alkanediol monoacylate is less than 0.5 wt.-%, preferably less than 0.1 wt.-%, based on the α,ω-C3-10alkanediol monoacylate and
    • the amount of the α,ω-C3-10alkanediol diacylate in the α,ω-C3-10alkanediol monoacylate is less than 5 wt. %, preferably less than 2.5 wt.-%, based on the α,ω-C3-10alkanediol monoacylate.

It is furthermore preferred that during said separation the reaction components to be recycled are collected.

Preferably, in all embodiments of the present invention, the acylation and the consecutive separation of the α,ω-C3-10alkanediol monoacylate is a (fully) continuous process carried out in a vessel cascade set-up or a cascade reactor as e.g. outlined in FIG. 1).

A vessel cascade set-up (also called reactor cascade set-up) for the purpose of the invention is a setup that comprises at least two consecutive vessels, in which the reaction can be performed and wherein each step can only be performed after the previous one. The vessels/reactors can be of the same or different types. It is well understood by a person skilled in the art that the vessel cascade set-up may include devices for separation and/or distillation.

A cascade reactor for the purpose of the invention is a setup that comprises an outer reactor shell with at least one inlet at one end and at least one outlet at the opposite end, optional additional outlets for vapor and/or by-product removal, and optional ports for monitoring, sampling and/or mixing. Within the reactor, a series of two or more segmented reaction chambers (corresponding to at least two consecutive vessels) may be defined by partitions, in which the reaction can be performed and wherein each chamber/partition can only be flown through after the previous one. The reactor is preferably suitable for multiple different chemical reactions and need not be custom-made for a particular reaction. The cascade reactor may, for example be a flow reactor.

In a particular embodiment of the present invention, the acylation (including the subsequent separation of the obtained α,ω-C3-10alkanediol monoacylate) is a process encompassing the steps of

    • (A-1) Acylation of an α,ω-C3-10,1kanediol with an acylating agent (acylation reaction) in an initial vessel, with the proviso that in said acylation reaction per mole recycled acylate groups 0.5 to 1.5 mole of water is present and the molar ratio of the (molar) sum of the acylating agent, α,ω-C3-10alkanediol monoacylate and 2 times of α,ω-C3-10alkanediol diacylate to the sum of the α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate is selected in the range from 0.5 to 1.1 mol per mol of α,ω-C3-10alkanediol (also referred to as acetylation reaction mixture or ARM),
    • (A-2) Removal of the acylating agent and water to form a mixture comprising unreacted α,ω-C3-10alkanediol as well as mono- and diacylated α,ω- C3-10alkanediol (also referred to as AM-I),
    • (A-3) Separation of the α,ω-C3-10alkanediol monoacylate from said mixture (i.e. from AM-I) by distillation such that the thus obtained α,ω-C3-10alkanediol monoacylate contains less than 0.5 wt.-% of α,ω-C3-10alkanediol and less than 5 wt.-% of α,ω-C3-10alkanediol diacylate,
    • (A-4) Collecting the reaction components to be recycled, and
    • (A-5) Re-feeding the recycled reaction components comprising at least α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate into the initial vessel.

In all embodiments of the present invention it is preferred that within the acylation reaction, such as in particular in step (A-1)

    • per mole recycled acylate groups preferably 0.75 to 1.25 mole, most preferably 0.85 to 1.1 mole such as in particular 0.95 to 1.05 mole of water is present, and
    • the molar ratio of the (molar) sum of the acylating agent, α,ω-C3-10alkanediol monoacylate and 2 times α,ω-C3-10alkanediol diacylate to the sum of the α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate is preferably selected in the range from 0.6 to 1 mol, most preferably in the range from 0.7 to 1 mol, such as in particular in the range from 0.75 to 1 mol.

The term ‘per mole acylate groups’ as used herein refers to the sum of acylate groups from the α,ω-C3-10alkanediol monoacylate and the α,ω-C3-10alkanediol diacylate (i.e. 1 mol for each α,ω-C3-10alkanediol monoacylate and two moles for each α,ω-C3-10alkanediol diacylate).

As already outlined above, the reaction components to be recycled in step (A-5) consist essentially of α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate. However, it is not excluded by the present invention that the acylating agent and/or the water removed in step (A-2) can also be recycled and re-fed as deemed appropriate.

It is furthermore well understood, that, to adjust the ratios and amounts as defined herein, fresh α,ω-C3-10alkanediol, water and/or acylating agent are added as needed.

Suitable acylating agents (also referred to herein to as AA) for the acylation processes according to the present invention are carboxylic acids and derivatives thereof such as e.g. the respective, esters and acyl halides thereof. Preferably, the acylating agent is selected from the group consisting of linear or branched C1-6 alkanoic acids respectively, esters or acid chlorides thereof, more preferably from linear C1-4 carboxylic acids such as for example acetic acid, propanoic acid, butanoic acid and pentanoic acid. The most preferred acylating agent is acetic acid. Any acetic acid, i.e. also aqueous solutions thereof can be used in all embodiments of the acylation. It is however understood, that the water content has to be adjusted accordingly to comply with the requirements according to the present invention.

The reaction temperature for the acylation reaction is preferably selected in the range from 80 to 200° C., more preferably in the range from 100 to 160° C., most preferably in the range of 120 to 150° C. It is well understood, that the pressure has eventually to be adjusted according to the desired reaction temperature.

The reaction time for the acylation reaction (such as in particular in step (A-1)) is preferably selected in the range from 1 to 10 hours, preferably in the range from 2 to 8 hours, most preferably in the range from 3 to 6 hours.

The removal of the acylation agent and reaction water in step (A-2) is preferably performed by distillation at reduced pressure and heating, which can be easily adjusted by a person skilled in the art. Suitable pressures include 40 to 120 mbar abs.

The separation of the α,ω-C3-10alkanediol monoacylate from the reaction mixture (i.e. from AM-I) is preferably performed such, that the amount of α,ω-C3-10alkanediol diacylate therein is less than 4 wt.-%, more preferably less than 3 wt.-%, most preferably less than 2.5 wt.-% such as less than 1 wt.-%, and the amount of the respective α,ω-C3-10alkanediol therein is less than 0.4 wt.-%, more preferably, less than 0.25 wt.-%, most preferably less than 0.2 wt.-%, such as in particular less than 0.1 wt.-% (all amounts based on the amount of the α,ω-C3-10alkanediol monoacylate).

The amount of residual α,ω-C3-10alkanediol diacylate and α,ω-C3-10alkanediol in the isolated (distilled) α,ω-C3-10alkanediol monoacylate is generally determined by GC chromatography using a FID detector.

In a particularly advantageous embodiment, the separation/purification of the α,ω-C3-10alkanediol monoacylate (i.e. Step (A-3)) is performed in two consecutive steps, i.e.

    • Step (A-3′) consisting of distilling off the majority of the α,ω-C3-10alkanediol diacylate from the mixture (AM-I) obtained in step (A-2) until a mixture (AM-Ia) is obtained, which consists essentially of α,ω-C3-10alkanediol and α,ω-C3-10alkanediol monoacetate followed by
    • Step (A-3″) consisting of distilling off the α,ω-C3-10alkanediol monoacylate from the mixture (AM-Ia) such that the amount of α,ω-C3-10alkanediol in the distilled α,ω-C3-10alkanediol monoacetate is as defined herein, while preferably recovering unreacted α,ω-C3-10alkanediol.

The term consisting essentially in Step (A-3′) does not exclude the presence of small amounts of α,ω-C3-10alkanediol diacetate, which amounts however have to be controlled such, that the final amount of α,ω-C3-10alkanediol diacetate in the α,ω-C3-10alkanediol monoacetate is as defined herein. Preferably, said amount does however not exceed 3 mole.-%.

It is even more preferred, that step (A-3′) and step (A-3″) are performed in two distinct vessels (distillation set-ups).

In an even more preferred embodiment step (A-3′) and step (A-3″) are performed using two separate distillation columns.

In a particular embodiment, the mixture (AM-I) consists essentially of 40 to 60 mol-% of α,ω-C3-10alkanediol, 30 to 50 mol-% of α,ω-C3-10alkanediol monoacylate and 5-15 mol-% α,ω-C3-10alkanediol diacylate.

In another particular embodiment, the mixture (AM-Ia) consists essentially of 50 to 70 mol-% of α,ω-C3-10alkanediol and 30 to 50 mol-% of α,ω-C3-10alkanediol monoacylate and up to 3 mol.-% of α,ω-C3-10alkanediol diacylate.

The reaction components to be recycled, i.e. which are re-fed into the acylation reaction such as in particular into step (A-1) above generally consist of the distillate of step (A-3′) consisting essentially of α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate and the sump of step (A-3″) consisting essentially of unreacted α,ω-C3-10alkanediol.

Preferably, the distillate of step (A-3′) consists essentially of 10 to 40 wt.-% of α,ω-C3-10alkanediol monoacylate and 60 to 90 wt.-% of α,ω-C3-10alkanediol diacylate and up to 5 wt.-% α,ω-C3-10alkanediol.

Preferably the sump of step (A-3″) consists essentially of more than 95 wt.-% of α,ω-C3-10alkanediol, more preferably of more than 97 wt. %, most preferably of more than 99 wt.-%.

The α,ω-C3-10alkanediol monoacylate obtained in step (A-3″) preferably exhibits a purity of more than 95 wt.-%, preferably of more than 97 wt.-%, most preferably of more than 98.5 wt.-% as determined by GC analysis using a FID detector.

In a particular advantageous embodiment of the present invention, the acylation (including the subsequent separation of the obtained α,ω-C3-10alkanediol monoacylate) is a process as outlined in FIG. 1 encompassing the steps of

    • (A-0) Provision of a vessel cascade setup,
    • (A-1′) Acylation of the α,ω-C3-10alkanediol with an acylating agent with all the definitions and preferences as given herein by loading the first vessel (V1) with the α,ω-C3-10alkanediol, the acylating agent and the recycled reaction components to form a reaction mixture (ARM), followed by
    • (A-2′) Feeding the reaction mixture (ARM) onto a first distillation column (V2) and distilling off the acylating agent and water to form a mixture (AM-I) consisting essentially of unreacted α,ω-C3-10alkanediol and mono- and diacylated α,ω-C3-10alkanediol, followed by
    • (A-3′) Feeding the mixture (AM-I) onto a second distillation column (V3) and distilling off a mixture of α,ω-C3-10alkanediol mono and diacylate (i.e. RRC-(I)) to form a mixture (AM-Ia) consisting essentially of α,ω-C3-10alkanediol and α,ω-C3-10alkanediol monoacetate,
    • (A-3″) Feeding the mixture (AM-Ia) onto a third distillation column (V4) and distilling off the α,ω-C3-10alkanediol monoacylate such that the amount of α,ω-C3-10alkanediol in the distilled α,ω-C3-10alkanediol monoacetate is less than 0.1 wt.-% and while recovering the α,ω-C3-10alkanediol from the sump (i.e. RCC-(II)),
    • (A-4′) Collecting and optionally mixing the reaction components to be recycled, and
    • (A-5′) Re-feeding the optionally admixed recycled reaction components RRC-(I) and RRC-(II) from step (iv) and (v) into the first reaction vessel (V1),
    • with the proviso that in the first reactor vessel
      • (a) per mole recycled acylate groups 0.5 to 1.5 mole, preferably 0.75 to 1.25 mole, most preferably 0.85 to 1.1 mole, such as in particular 0.95 to 1.05 mole of water is present, and
      • (b) the molar ratio of the (molar) sum of the acylating agent, α,ω-C3-10alkanediol monoacylate and 2 times of α,ω-C3-10alkanediol diacylate to the sum of the α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and the α,ω-C3-10alkanediol diacylate is adjusted in the range 0.5 to 1.1 mol per mol of α,ω-C3-10alkanediol, preferably in the range from 0.6 to 1 mol, most preferably in the range of 0.7 to 1 mol such as in the range from 0.75 to 1 mol.

It is well understood, that the recycled reaction components (I) may contain α,ω-C3-10alkanediol monoacylate such as in amounts of up to 45 wt.-% as determined by e.g. GC-analysis using FID detector.

Preferably, in all embodiments the recycled reaction components (II) consists of more than 90 wt.-% of α,ω-C3-10alkanediol, more preferably of more than 95 wt. %, most preferably of more than 98 wt.-% of α,ω-C3-10alkanediol, as determined by e.g. GC-analysis using a FID detector.

It is, of course, well understood, that all the definitions and preferences for the acylation (including the acylation reaction and separation) herein also apply to the processes comprising the steps (A-1) to (A-5) as well as (A-0) to (A-5′).

Nitrate Ester Formation

In a preferred embodiment, the process according to the present invention also comprises a step (B), following step (A) and preceding step (C) directed to a continuous nitrate ester formation process for the preparation of α,ω-C3-10alkanediol mononitrate monoacylates, said process comprising reacting a nitrating agent with a solution comprising the respective α,ω-C3-10alkanediol monoacylate and an inert solvent (in the following also referred to as (B-I)) in a group of pieces of equipment comprising at least two reactors in series, characterized in that the solution is simultaneously fed into the first (also referred to as reactor B1) and the second (also referred to as reactor B2) reactor (see FIG. 2).

Preferably, the nitrate ester formation is carried out continuously in a flow-reactor as e.g. depicted in FIG. 2.

A flow reactor according to this invention is a device in which chemical reactions take place in channels or tubes. The flow reactor is generally operated continuously (in contrast with/to a batch reactor) and has channels/tubes in which the reaction takes place (such as the reactors B1 and B2 in FIG. 2). The reaction stoichiometry is defined by the concentration of reagents and the ratio of their flow rate. The (mean) residence time is given by the ratio of volume of the reactor and the overall flow rate. The flow reactor preferably comprises (static) mixing elements, such as SMX mixer or Kenics mixer.

The term “residence time” as used herein refers to the volume of the reaction zone divided by the outlet volumetric flow rate of reactants at the reaction system's temperature and pressure. In a specific embodiment of the invention the mean residence time is calculated with the density of the respective outlet temperature of the reactor.

Preferably, the mass flow ratio of the solution (B-I) into the first reactor is selected in the range of 40 to 60% of the total mass flow of the solution (B-I), the remaining is fed to the second reactor.

The term “mass flow” or “mass flow rate” as used herein may include not only the actual or measured mass flow rate, but also the calculated mass flow rate. It generally refers to the mass flow rate of a reaction solution as measured in the corresponding feed lines. This mass flow rate can be calculated or measured with a suitable sensor located in the corresponding feed lines.

In a particular advantageous embodiment the continuous nitrate ester formation according to the present invention comprises the following consecutive steps:

    • (N-1) Provision of a continuously operated flow-reactor comprising at least two reactors, reactor (1) (also referred to herein as B1) and reactor (2) (also referred to herein as B2), in series
    • (N-2) Provision of a solution comprising an α,ω-C3-10alkanediol monoacylate and an inert solvent (i.e. B-I), and
    • (N-3) Feeding of reactor (1) with a nitrating agent and a first portion of said solution, followed by
    • (N-4) Adding a second portion of said solution into the reactor (2), with the proviso that the mass flow of the solution into the reactor 1 is selected in the range of 40 to 60% of the total mass flow of the solution, while the remaining solution is fed into reactor 2.

The term “nitrating agent” (also referred to herein as NA) as used herein refers to a compound which when reacted with a reactant substrate forms a compound with a nitrate ester (—O—NO2) group. Exemplary nitrating agents include, but are not limited to, nitric acid and nitrate salts, such as alkali metal nitrate salts, e.g., KNO3, as well as nitrosulfuric acid (i.e. a mixture of nitric acid and sulphuric acid)

In all embodiments of the present invention, the nitrating agent is preferably nitric acid applied as nitrosulfuric acid, i.e. a mixture of nitric acid and sulphuric acid.

In the continuous nitrate ester formation according to the present invention, preferably 1.5 to 2.5 mol equivalents, more preferably 1.7 to 2.3 mol equivalents, most preferably 1.9 to 2.0 mol equivalents of H2SO4, based on HNO3 is used.

In the continuous nitrate ester formation according to the present invention, preferably from 1 to 1.5 mol equivalents, more preferably from 1.1 to 1.2 mol equivalents of HNO3, based on the α,ω-C3-10alkanediol monoacylate is used.

In the continuous nitrate ester formation according to the present invention it is furthermore preferred that the reaction volume of the reactor (1) to the reactor (2) is selected in the range from 4:1 to 1:4, preferably from 3:1 to 1:3, most preferably from 2:1 to 1:2.

The continuous nitrate ester formation is preferably carried out for a mean residence time in both reactors (i.e. in reactor (1) and reactor (2) (FIG. 2: in B1 and B2) ranging from about 5 to about 30 seconds, preferably from about 10 to about 20 seconds, most preferably from about 15 to 19 seconds.

Preferably in all embodiments of the continuous nitrate ester formation, the solution (i.e. B-I) consists essentially of the α,ω-C3-10alkanediol monoacylate and the inert solvent.

The term ‘consisting essentially of’ as used according to the present invention means that besides the listed components/ingredients/solvents no further components are purposively added. It is however not excluded that small amount of impurities introduced by the respective raw materials may be present.

Even more preferably, the concentration of the α,ω-C3-10alkanediol monoacylate in the inert solvent is selected in the range from 10 and 60 wt.-%, more preferably from 20 and 50 wt.-% and most preferably from 35 and 45 wt.-%, the remainder being the inert solvent.

In a particular advantageous embodiment the continuous nitrate ester formation according to the present invention further comprises the following steps:

    • (N-5a) Quenching (in B3) the reaction mixture (also referred to herein as NRM) with water, optionally in the presence of a base resulting in a biphasic mixture (also referred to herein as NBM) consisting of an organic and aqueous phase,
    • (N-5b) Phase separation (in B4) of the biphasic mixture (NBM) to obtain an organic (also referred to herein as NOP) and an aqueous phase (also referred to herein as NAP),
    • (N-5c) optionally Concentrating the aqueous phase (NAP) from phase separation to recover H2SO4 if no base was used for neutralization, and
    • (N-5d) optionally Washing the organic phase (NOP) obtained in (N-5c) at least once with water and/or drying the organic phase.

A particularly preferred continuous nitrate ester formation is outlined in FIG. 2, which continuous nitrate ester formation consists of the consecutive steps (N-1), (N-2), (N-3), (N-4), (N-5a), (N-5b) and (N-5c).

It is well understood that the continuous nitrate ester formation according to the present invention may also comprise the step of isolating/concentrating the α,ω-C3-10alkanediol mononitrate monoacylate from the organic phase (NOP) e.g. by (partial) distillation of the solvent.

The nitrate ester formation reaction mixture (NRM) in all embodiments of the present invention preferably consists essentially of the remaining/unreacted nitrating agent, α,ω-C3-10alkanediol mononitrate monoacylate, unreacted α,ω-C3-10alkanediol monoacylate and inert solvent.

Suitable bases include alkali or earth alkali bases such as alkali or earth alkali hydroxides or carbonates as well as ammonia, amines without being limited thereto. The base is preferably selected from the group of NaOH (caustic), KOH, Ca(OH)2 or ammonia, more preferably an aqueous solution thereof is used. Most preferably in all embodiments of the present invention the base is aqueous NaOH (caustic).

In the continuous nitrate ester formation according to the present invention preferably no base is used for quenching.

Thus, in a further particular advantageous embodiment, the quenching of the nitrate ester formation reaction mixture (NRM) is performed either with cold water, such as with water having a temperature selected in the range from 0 to 20° C., more preferably in the range from 5 to 15° C.

In the continuous nitrate ester formation according to the present invention, advantageously, the outlet reaction temperature of the reactor (1) is equal to or below 40° C., preferably 30° C., more preferably 20° C., more preferably 10° C. and most preferably equal to or below 5° C. The outlet reaction temperature of reactor (2) can be slightly higher. Preferably, however the outlet temperature of reactor (2) is selected in the range of 15 to 25° C.

Advantageously, in all embodiments, the reaction temperature for the quenching step (N-6a) is equal to or below 20° C., preferably equal to or below 15° C., more preferably equal to or below 10° C.

Removal and Recovery of the Inert Solvent

In a further preferred embodiment, the process according to the present invention further comprises a step (D) (following step (C) directed to a process for removal and recovery of an inert solvent from a mixture comprising the inert solvent and an α,ω-C3-10alkanediol mononitrate by distillation, said process comprising partial evaporation and condensation and continuous back-feeding of liquid fractions comprising mixtures of the inert solvent and the α,ω-C3-10alkanediol mononitrate into said distillation.

Preferably, said distillation is performed in an evaporator setup, even more preferably in an evaporated set-up comprising from 1 to 5 evaporators, more preferably 2 to 4 evaporators. An exemplary, while preferred, evaporator set-up is outlined in FIG. 4.

Said process preferably also comprises the isolation of the α,ω-C3-10alkanediol mononitrate in a purity of at least 95 wt.-%, preferably at least 97 wt.-%, most preferably at least 98 wt.-%, as e.g. determined by GC chromatography using a FID detector.

Preferably, said isolated α,ω-C3-10alkanediol mononitrate furthermore comprises less than 1 of the inert solvent, more preferably less than 0.5% of the inert solvent most preferably less than 0.1% of the inert solvent.

The term ‘evaporator’ as used herein refers to a device used to turn a liquid form of a chemical substance or a mixture of chemical substance (such as the solution of the inert solvent and the α,ω-C3-10alkanediol mononitrate) into its/their gaseous-form/vapor. It is well understood, that the liquid may also be only partially evaporated, or partially vaporized, into the gas form, while part of the liquid remains liquid. Said process can be used for the separation of mixtures, e.g. by partial evaporation and partial condensation as illustrated herein.

The term condenser as used herein refers to a device or unit used to condense a gaseous substance or gaseous mixture into a liquid state through cooling.

In a particular advantageous embodiment, the solvent removal and recovery according to the present invention comprises the following steps:

    • (S-1) Provision of an evaporator setup comprising 3 evaporators,
    • (S-2) Feeding of a solution comprising an α,ω-C3-10alkanediol mononitrate in an inert solvent (also referred to herein as S-I) onto a first evaporator (FIG. 4: E1) and applying a pressure of 400 to 600 mbar resulting in a gaseous phase (I) (also referred to herein as GP-I) and a liquid phase (I) (also referred to herein as LP-I), wherein said liquid phase (I) comprises from about 70 to 95 wt.-% of the α,ω-C3-10alkanediol mononitrate,
    • (S-3) Feeding said gaseous phase (I) onto a first (partial) condenser (C1) to remove a first liquid fraction (also referred to herein as LF-I) by cooling to a temperature of 20 to 40° C., preferably to a temperature of 20 to 35° C., more preferably to a temperature of 25-30° C., while passing the remaining gaseous phase (II) (also referred to herein as GP-II) onto a second condenser (FIG. 4: C2),
    • (S-4) Feeding the liquid phase (I) (LP-I) from step (S-2) onto a second evaporator (FIG. 4: E2) and applying a pressure of 50 to 150 mbar resulting in a gaseous phase (III) (also referred to herein as GP-III) and a liquid phase (II) (also referred to herein as LP-II), wherein the liquid phase (II) comprises more than 95 wt.-%, preferably more than 97 wt.-%, most preferably more than 98 wt.-% of the α,ω-C3-10alkanediol mononitrate,
    • (S-5) Feeding the gaseous phase (III) onto a third (partial) condenser (FIG. 4: C3) to remove a second liquid fraction (also referred to herein as LF-II) by cooling to a temperature of 10 to 30° C., preferably to a temperature of 20 to 30° C., more preferably to a temperature of 20 to 25° C., while passing the remaining gaseous phase (IV) (also referred to herein as GP-IV) onto a fourth condenser (FIG. 4: C4) to liquefy the inert solvent, and
    • (S-6) Feeding the liquid phase (II) (LP-II) from step (S-4) onto a third evaporator (FIG. 4: E3) and applying a pressure of 5 to 10 mbar with the proviso that at least one of LF-I and LF-II is fed back onto the first or the second evaporator.

It is well understood that the liquid fractions (I) and (I) still contain α,ω-C3-10alkanediol mononitrate, which is recovered by said back-feeding.

An exemplary (while preferred) removal and recovery process according to the present invention is illustrated in FIG. 4.

In a partial condensation according to this invention, a vapour stream (vaporized stream) is partially condensed (liquefied) in a condenser. The remaining (not condensed) vapor is passed to a subsequent (total) condenser operated at lower temperatures to almost liquefy the remaining solvent.

Preferably, the amount of the α,ω-C3-10alkanediol mononitrate in the inert solvent in step (S-2) is selected in the range from 10 to 50 wt.-%, more preferably in the range from 20 to 40 wt.-%, which is e.g. obtainable from the hydrolysis as outlined above.

DESCRIPTION OF THE FIGURES

FIG. 1: In the embodiment of FIG. 1, an exemplary, but none limiting vessel cascade setup for the acylation process according to the present invention is shown:

The acylating agent (AA), the α,ω-alkanediol (AD) and water are fed into the first vessel of a vessel cascade (V1) to form the reaction mixture (ARM). The reaction mixture (ARM) is then fed onto a first distillation column (V2) and the acylating agent and water are distilled off to form a mixture (AM-I). The mixture (AM-I) is subsequently fed onto a second distillation column (V3) and the ‘recycled reaction components (I)’ consisting essentially of α,ω-alkanediol mono- and diacylate (ADMA & ADDA) are distilled off to form a mixture (AM-Ia). The mixture (AM-Ia) is then fed onto a third distillation column (V4) and ADMA is distilled off while recovering ‘recycled reaction components (II)’ consisting essentially of AD. During the process the recycled reaction components (I) and (II) are continuously re-fed into the first reaction vessel (V1). A small fraction (below 5%) of the recycled reaction components (I) and (II) can be purged/removed to avoid accumulation of possible formed by-products if necessary. In addition, the acylating agent as well as (part of) the water is re-fed as deemed appropriate into the first reaction vessel (V1).

FIG. 2: In the embodiment of FIG. 2, an exemplary, but none limiting continuously operated flow-reactor setup for the nitrate ester formation according to the present invention is shown:

The nitrating agent as well as part of the solution (B-I) consisting of α,ω-C3-10alkanediol monoacylate and the inert solvent are fed into a first reactor (B1) followed by adding a second portion of the solution (B-I) into the second reactor (B2). The nitrate ester formation reaction mixture (NRM) obtained after reactor (B2) is quenched in reactor B3. The thus obtained reaction biphasic mixture (NBM) is split into two phases to obtain an organic (NOP) and an aqueous phase (NAP). The α,ω-C3-10alkanediol mononitrate monoacylate (ADMNMA) is in said organic phase and can be isolated thereof.

FIG. 3: In the embodiment of FIG. 3, an exemplary, but not limiting vertical, stirred cascade reactor setup for the hydrolysis process according to the present invention is shown.

The first (bottom) chamber (C1) is continuously loaded with a solution consisting essentially of an α,ω-C3-10alkanediol mononitrate monoacylate and an inert solvent (HS-I) (such e.g. with the NOP obtained as outlined in FIG. 2) and an aqueous solution of a base to form a reaction mixture (HRM). The reaction mixture (HRM) is transferred into a second vessel (C2) for phase separation resulting in an organic phase (HS-II) and an aqueous phase (HS-III). The organic phase is transferred to a evaporator setup (C4) for isolation of the α,ω-C3-10alkanediol mononitrate (ADMN) The aqueous phase (HS-III) is transferred into a third vessel (C3) for further extraction with the inert solvent to obtain an organic phase HS-IV) which is also transferred (combined with HS-II) to the evaporator setup (C4) to recover further ADMN.

FIG. 4: In the embodiment of FIG. 4, an exemplary, but none limiting evaporator setup for the removal and recovery of the inert solvent according to the present invention is shown: A solution comprising an α,ω-C3-10alkanediol mononitrate in an inert solvent (S-I) is fed onto a first evaporator (E1) and a first liquid fraction (LF-I) is removed from the distillate of evaporator (E1) through partial condensation in a first condenser (C1) while the remaining vapors pass onto a second condenser (C2) to liquefy the remaining inert solvent (S). The liquid phase (LP-I) from evaporator (E1) is fed onto a second evaporator (E2). A second liquid fraction (LF-II) is removed from the distillate of evaporator (E2) through partial condensation in a condenser (C3), while the remaining vapors (GP-IV) pass onto a fourth condenser (C4) to liquefy the remaining inert solvent. The liquid phase (LP-II) from evaporator (E2) is fed into a third evaporator (E-3) to remove the remaining inert solvent and to recover the pure α,ω-C3-10alkanediol mononitrate.

 EXAMPLE

A) Acylation

    • The acetylation (equilibrium formation) was performed either batchwise without recycles or in a vessel cascade setup in a fully continuous process, by feeding the starting materials into a first vessel. The resulting reaction mixture from the last vessel is fed onto a first distillation column for separation (removal) of H2O/HAc from PDDA/PDMA/PD. This mixture of PDDA/PDMA/PD is fed to a second rectification column for removal of PDDA from PD/PDMA. This mixture of PD/PDMA is fed to a third rectification column for separation of PDMA from PD.
    • Pure PDMA was obtained by rectification. Recovered PDDA, PD and HAc were recycled and fed back together with the adjusted amount of water to the reaction vessel cascade, allowing for an overall yield of 90%.
    • Aa) Without Using Recycling Streams (Comparative) 1,3-Propanediol (PD, 14.0 kg, 0.18 kmol, 99.7%) was mixed with Acetic Acid (HAc, 9.8 kg, 0.16 kmol, 100%). After inerting of the reactor by nitrogen flow, strirring was started (500 rpm) and the jacket temperature was increased from 20° C. to 135° C. within 70 minutes and kept at 135° C. at 4 hours and at reflux of reaction mixture. After 4 hours the jacket temperature was set to 100° C. and the pressure is slowly reduced to approx. 100 mbar abs. while removing 1.55 kg distillate. 22.0 kg residue were obtained comprising a mixture of acetic acid, water, unreacted PD (28 wt %), 3-acetylpropan-1-ol (PDMA, 44.1 wt %) and 1,3-propanedioldiacetate (PDDA, 11.3 wt %). Yield of PDMA was 44.4% and of PDDA was 8.5% based on PD.
    • Removal of acetic acid/water was performed at 50 mbar abs top pressure in a rectification column DN50 with 3.5 m BX packing equipped with condenser, liquid separator for reflux adjustment and falling film evaporator with a feed rate of 6.7 kg/h and reflux ratio of 0.4-0.5 resulting in a top take off of 1.1 kg/h containing acetic acid and water and s sump stream of 5.6 kg/h (34 wt % PD, 52 wt % PDMA, 13 wt % PDDA).
    • Removal of PDDA was performed at 20 mbar abs top pressure in a rectification column DN50 with 3.5 m BX packing equipped with condenser, liquid separator for reflux adjustment and falling film evaporator with a feed rate of 1.6 kg/h and reflux ratio of 7-8 resulting in a top take off of 0.4 kg/h containing 1 wt % PD, 40 wt % PDMA, and 54 wt % PDDA. The corresponding sump stream (1.2 kg/h) consisted of 44 wt % PD, 55 wt % PDMA, 0.3 wt % PDDA.
    • Separation of PDMA from PD was performed at 20 mbar abs top pressure in a rectification column DN50 with 3.5 m BX packing equipped with condenser, liquid separator for reflux adjustment and falling film evaporator with a feed rate of 1.2 kg/h and reflux ratio of 3-4 resulting in a top take off of 0.6 kg/h containing 0.5 wt % PD, 97-98 wt % PDMA, and 1 wt % PDDA. The corresponding sump stream (0.6 kg/h) consisted of 91-92 wt % PD, 8-9% PDMA. Overall Yield of PDMA during the three rectification steps was 71-73%.
    • Overall yield of PDMA (reaction and rectification steps) based on PD was 31-33%.
    • Ab) using recycling streams in fully continuous mode (inventive)
    • 1,3-Propanediol (PD, 76 kg/h, 0.99 kmol/h, 99.7%) was mixed with fresh Acetic Acid (HAc, 57 kg/h, 100%), 89 kg/h distillate from the first rectification column (56 wt % acetic acid, 44 wt % water), 90 kg/h distillate of the 2nd rectification column (2 wt % PD, 36.5 wt % PDMA, 61 wt % PDDA) and 110 kg/h sump stream from the third rectification column (97 wt % PD, 3% PDMA). The reaction was performed in a continuous stirred tank reactor at reflux temperature (atmospheric pressure) with a mean residence time of 5-6 hours to deliver 400 kg/h reaction mixture (mixture of acetic acid, water, unreacted PD (29 wt %), 3-acetylpropan-1-ol (PDMA, 35 wt %) and 1,3-propandioldiacetate (PDDA, 14.5 wt %)). Removal of acetic acid/water was performed at 50 mbar abs top pressure in a rectification column DN500 with 3.7 m BX packing equipped with condenser, liquid separator for reflux adjustment and falling film evaporator with a feed rate of 400 kg/h and reflux ratio of 0.5-1 resulting in a top take off of 85 kg/h containing acetic acid and water and sump stream of 315 kg/h (36 wt % PD, 45 wt % PDMA, 19 wt % PDDA).
    • Removal of PDDA was performed at 20 mbar abs top pressure in a rectification column DN1000 with 10.8 m BX packing equipped with condenser, liquid separator for reflux adjustment and falling film evaporator with a feed rate of 315 kg/h and reflux ratio of 10-15 resulting in a top take off of 92 kg/h containing 2 wt % PD, 36.5 wt % PDMA, and 61 wt % PDDA. The corresponding sump stream (223 kg/h) consisted of 50 wt % PD, 48-49 wt % PDMA, 1-2 wt % PDDA.
    • Separation of PDMA from PD was performed at 10 mbar abs top pressure in a rectification column DN1000 with 7.5 m BX packing equipped with condenser, liquid separator for reflux adjustment and falling film evaporator with a feed rate of 223 kg/h and reflux ratio of 5-10 resulting in a top take off of 108 kg/h containing 0.1 wt % PD, 98-99 wt % PDMA, and 1 wt % PDDA. The corresponding sump stream (115 kg/h) consisted of 98-99 wt % PD, 1-2% PDMA.
    • Overall yield of PDMA (reaction and rectification steps) based on (fresh) PD was 90%.

B) Nitrate Ester Formation

    • A 40% w/w solution of PDMA in Dichloromethane (DCM) was reacted at 5° C. in a flow-reactor with Nitrosulfonic acid (1.1 eq HNO3, 2.2 eq H2SO4, less than 3 wt % water).
    • The nitrate ester formation reaction was performed in a continuously operated flow-reactor, by mixing PDMA in DCM (60 wt % DCM/40 wt % PDMA) with Nitrosulfuric acid in a constant ratio and a steady flow of both components. To control the reaction temperature below 40° C., the reaction was partitioned by massflow between two serial flow-reactors by feeding PDMA in 2 portions (reactor 1/reactor 2=40%:60%). The overall residence time in both reactors was kept at 15-19 seconds.
    • Directly after the 2 sequential reactors, the reaction was diluted/quenched with water at 10° C., followed by a phase separation. The organic phase, containing the intermediate 3-acyl-propan-1-nitrate (MAMN) was washed once with water, stabilizing the mixture for intermediate storage in a buffer tank. The organic phase, containing MAMN can be subjected as-is to the next step or optionally washed with water prior to the next step, with an overall yield of 99%
    • The aqueous phase consisting mainly of diluted H2SO4 was concentrated to 65 or 96% H2SO4 for use in other applications.

C) Hydrolysis

    • PDMNMA (ca 50% in DCM) was reacted at 40-56° C. with 1,3 eq. NaOH (10-11% solution in water).
    • The hydrolysis of PDMNMA was performed in a vertical, stirred cascade reactor, by continuously feeding PDMNMA (ca 50% in DCM) together with 10-11% NaOH solution (in a ratio 1/1.3 eq.) from the bottom. Residence time was 4 hours, at a reaction temperature of 40-56° C. After complete conversion (>99.9%), the phases were cooled to appr. 20° C., split, and the aq. phase was washed/extracted in continuous mode with DCM (back-extraction of PDMN) at room temperature. The combined organic phases were subjected to solvent removal (see D) Workup).
    • The desired product is obtained in 97% yield, after removal of DCM from the combined organic phases.

D) Solvent Removal and Recovery (Partial Condensation)

    • After hydrolysis, the combined organic phases PDMN/DCM (77% DCM) were subjected to solvent removal in a 3-stage evaporator setup, by feeding the organic phases into a first evaporator where PDMN solution (containing 7-8% DCM) was produced at 500 mbar. The distillates (vapour stream) were directed to a partial condenser, where a liquid fraction (PDMN/DCM, ca. 55-60% PDMN) was recovered at 30° C. and fed back to the first evaporator. The remaining vapors passed to a (total) condenser operated at 0° C. to recover DCM in high purity (<0.03% PDMN).
    • The PDMN solution from the first evaporator (containing 7-8% DCM) is fed to a second evaporator operated at 100 mbar to produce a liquid solution containing ca. 1 wt % DCM. The distillates (vapour stream) were directed to a partial condenser, where a liquid fraction (PDMN/DCM, ca. 70-75% PDMN) was recovered at 15° C. and fed back to the first evaporator. The remaining vapors passed to a (total) condenser operated at 0° C. to recover DCM (ca. 0.1% PDMN).
    • The PDMN solution from the second evaporator (containing ca. 1% DCM) is fed to a third evaporator operated at 10 mbar to produce a liquid solution containing less than 0.1 wt % DCM. The distillates (vapour stream) were directed to a partial condenser, where a liquid fraction (PDMN/DCM, ca. 90% PDMN) was recovered at 0° C. and fed back to the first evaporator. The remaining vapors were discarded.

Claims

1. A continuous process for the two-phase hydrolysis of α,ω-C3-10alkanediol mononitrate monoacylates, said process comprising continuously feeding a base and a solution comprising an α,ω-C3-10alkanediol mononitrate monoacylate and an inert solvent into a stirred cascade reactor.

2. The hydrolysis process according to claim 1, wherein the base is selected from the group of NaOH, KOH, Ca(OH)2 or ammonia or an aqueous solution thereof, preferably the base is an aqueous solution of NaOH.

3. The hydrolysis process according to claim 1, wherein the concentration of the base in the aqueous solution is selected in the range from 1 and 50 wt.-%, more preferably from 5 and 30 wt.-%, most preferably from 7.5 and 15 wt.-%.

4. The hydrolysis process according to claim 1, wherein the reaction temperature is selected in the range from 20 to 70° C., preferably from 30 to 60° C., and most preferably from 40 to 56° C.

5. The hydrolysis process according to claim 1, wherein 1 to 1.5 mol equivalents, more preferably 1.1 to 1.3 mol equivalents, most preferably 1.3 mol equivalents of the base, based on the α,ω-C3-10alkanediol mononitrate monoacylate is used.

6. The hydrolysis process according to claim 1, wherein the hydrolysis is carried out for a reaction time ranging from about 2 to about 6 hours, preferably from about 3 to about 5 hours, most preferably for about 4 hours.

7. The hydrolysis process according to claim 1, wherein the process is used for the preparation of an α,ω-C3-10alkanediol mononitrate, preferably 3-nitrooxypropane-1-ol, said process further comprising the preceding steps (A) and (B) consisting of

(A) Acylation of an α,ω-alkanediol, with an acylation agent (acylation reaction), said acylation comprising the step of re-feeding recycled reaction components comprising α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate back into said acylation reaction and with the proviso that in the acylation reaction per mole recycled acylate groups 0.5 to 1.5 mole of water is added and that the molar ratio of the (molar) sum of the acylating agent, α,ω-C3-10alkanediol monoacylate and 2 times of α,ω-C3-10alkanediol diacylate to the sum of the α,ω-C3-10alkanediol, α,ω-C3-10alkanediol monoacylate and α,ω-C3-10alkanediol diacylate is selected in the range from 0.5 to 1.1 mol per mol of α,ω-C3-10alkanediol to obtain a α,ω-C3-10alkanediol monoacylate,
(B) Continuous nitrate ester formation of the α,ω-C3-10alkanediol monoacylate by reacting a nitrating agent with a solution comprising the α,ω-C3-10alkanediol monoacylate and an inert solvent in a group of pieces of equipment comprising at least two reactors in series by simultaneously feeding said solution into the first and the second reactor to obtain the respective α,ω-C3-10alkanediol mononitrate monoacylate,
and optionally the consecutive step (D)
(D) Removal and recovery of the inert solvent from the solution by distillation, said process comprising partial condensation and continuous back-feeding of liquid fractions comprising mixtures of inert solvent and α,ω-C3-10 alkanediol mononitrate into said distillation.

8. The process according to claim 7, wherein the acylation step (A) is a continuous process carried out in a vessel cascade set-up.

9. The process according to claim 7, wherein the acylation step (A) comprises the step of separation of the α,ω-C3-10alkanediol monoacylate such that

a) the amount of α,ω-C3-10alkanediol in the α,ω-C3-10alkanediol monoacylate is less than 0.5 wt.-% and/or
b) the amount of the α,ω-C3-10alkanediol diacylate in the α,ω-C3-10alkanediol monoacylate is less than 5 wt. %.

10. The process according to claim 7, wherein the acylation agent in step (A) is selected from the group of carboxylic acids and/or derivatives thereof, more preferably of linear or branched C1-4 carboxylic acids, most preferably the acylation agent is acetic acid.

11. The process according to claim 7, wherein in the continuous nitrate ester formation of step (B) the mass flow of the solution into the first reactor is selected in the range of 40 to 60% of the total mass flow of the solution, while the remaining solution is fed into the second reactor.

12. The process according to claim 7, wherein in the continuous nitrate ester formation of step (B) the concentration of the α,ω-C3-10alkanediol monoacylate in the inert solvent is selected in the range from 10 and 60 wt.-%, more preferably from 20 and 50 wt.-% and most preferably from 35 and 45 wt.-%.

13. The process according to claim 7, wherein in the continuous nitrate ester formation of step (B) the nitrating agent is a mixture of H2SO4 and HNO3, wherein

a) the mol ratio of HNO3 to the α,ω-C3-10alkanediol monoacylate is selected in the range from 1 to 1.5, preferably from 1.1 to 1.2 and
b) the mole ratio of the H2SO4 to the HNO3 is selected in the range from 1.5 to 2.5, preferably from 1.7 to 2.3, most preferably from 1.9 to 2.0.

14. The process according to claim 7, wherein in the continuous nitrate ester formation of step (B) the reaction volume of the first reactor to the second reactor is selected in the range from 4:1 to 1:4, preferably from 3:1 to 1:3, most preferably from 2:1 to 1:2.

15. The process according to claim 7, wherein in the continuous nitrate ester formation of step (B) the nitrate ester formation is carried out for a mean residence time for the two reactors ranging from about 5 to about 30 seconds, preferably from about 10 to about 20 seconds, most preferably from about 15 to 19 seconds.

Patent History
Publication number: 20230150917
Type: Application
Filed: Apr 21, 2021
Publication Date: May 18, 2023
Inventors: Peter Hans RIEBEL (Kaiseraugst), Angela WILDERMANN (Kaiseraugst)
Application Number: 17/919,939
Classifications
International Classification: C07C 201/02 (20060101); C07C 203/02 (20060101);