Sublingual or buccal pharmaceutical composition

- Akzo Noble N.V.
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Claims

2. The pharmaceutical composition of claim 1, wherein the composition further comprises a pharmaceutically acceptable water-soluble or water-dispersable carrier material.

3. The pharmaceutical composition of claim 2, wherein the carrier material is partially hydrolysed gelatin.

5. The pharmaceutical composition of claim 1, wherein the composition disintegrates within 10 seconds in water at 37.degree. C.

6. The composition of claim 1, further comprising one or more pharmaceutically acceptable auxiliaries selected from the group consisting of hydrolyzed dextran, dextrin, mannitol, algenates, polyvinyl alcohol, polyvinyl pyrrolidine and water soluble cellulose derivatives.

9. The method of claim 4, wherein the composition is a solid pharmaceutical composition which rapidly disintegrates in the mouth of a subject upon insertion into the buccal pouch or upon placement under the tongue.

10. The method of claim 4, wherein the pharmaceutical composition further comprises pharmaceutically acceptable auxiliaries selected from the group consisting of hydrolyzed dextran, dextrin, mannitol, algenates, polyvinyl alcohol, polyvinyl pyrrolidine and water soluble cellulose derivatives.

11. The method of claim 10, wherein the pharmaceutically acceptable auxiliary is partially hydrolyzed gelatin.

Referenced Cited
Foreign Patent Documents
0569096 November 1993 EPX
0578823 January 1994 EPX
2366835 May 1978 FRX
Other references
  • Handbook of Pharmaceutical Excipients, ISBN (US): 0-917330-56-0, Published 1986, pp. 119-120.
Patent History
Patent number: 5763476
Type: Grant
Filed: Oct 11, 1996
Date of Patent: Jun 9, 1998
Assignee: Akzo Noble N.V. (Arnhem)
Inventors: Leonardus Petrus Carla Delbressine (Nijmegen), Johannes Hubertus Wieringa (Heesch)
Primary Examiner: Keith D. MacMillan
Attorneys: Sharon N. Klesner, Mary E. Gormley
Application Number: 8/693,064