Cephem derivatives
Cephem derivatives of the general formula ##STR1## is which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.
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Claims
1. A syn compound of the formula
- R.sub.3 is hydrogen, an alkali metal cation, or a carboxylic acid protecting group;
- R.sub.4 is hydrogen or methoxy;
- R.sub.1 is hydrogen or an amino protecting group; and
- R.sub.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl.
2. A syn compound as in claim 1 which is ##STR1100## wherein R.sub.3 is hydrogen or an alkali metal cation.
3. A syn compound of the formula ##STR1101##
4. A method for combating a bacterial infection in a patient suffering from such an infection, which method comprises administering to said patient a bactericidally effective amount of a compound as in claim 3.
5. A pharmaceutical composition for combating bacterial infections, acid composition comprising a bactericidally effective amount of a compound as in claim 3 and a pharmaceutically acceptable carrier therefor.
6. The compound of claim 1 wherein R.sub.3 is a carboxylic acid protecting group.
7. The compound of claim 6 wherein R.sub.3 is benzhydryl.
8. The compound of claim 1 wherein R.sub.3 is hydrogen or an alkali metal cation.
9. The compound of claim 8 wherein R.sub.4 is methoxy.
10. The compound of claim 8 wherein R.sub.4 is hydrogen.
11. The compound of claim 10 wherein R.sub.2 is C.sub.1 -C.sub.4 alkyl.
12. The compound of claim 11 wherein R.sub.2 is methyl.
13. The compound of claim 12 wherein R.sub.2 is hydrogen.
15. The compound of claim 3 wherein C.sub.1 -C.sub.4 -alkyl is methyl.
16. A method for combating a bacterial infection in a patient suffering from such an infection, which method comprises administering to said patient a bactericidally effective amount of a compound as in claim 1.
17. A pharmaceutical composition for combating bacterial infections, said composition comprising a bactericidally effective amount of a compound as in claim 1 and a pharmaceutically acceptable carrier therefor.
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| 4264595 | April 28, 1981 | Numata et al. |
| 4278671 | July 14, 1981 | Ochiai et al. |
| 4278793 | July 14, 1981 | Durkheimer et al. |
| 4298606 | November 3, 1981 | Ochiai et al. |
| 4303655 | December 1, 1981 | Komiya et al. |
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| 4366153 | December 28, 1982 | Takaya et al. |
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| 850662 | July 1977 | BEX |
| 852860 | September 1977 | BEX |
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| 857933 | February 1978 | BEX |
| 864074 | August 1978 | BEX |
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Type: Grant
Filed: Jul 11, 1990
Date of Patent: Mar 24, 1998
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main)
Inventors: Walter Durckheimer (Hattersheim am Main), Dieter Bormann (Kelkheim), Eberhard Ehlers (Hofheim am Taunus), Elmar Schrinner (Wiesbaden), Rene Heymes (Romainville)
Primary Examiner: MArk L. Berch
Law Firm: Curtis, Morris & Safford
Application Number: 7/551,615
International Classification: C07D501136; A61K 31545;
